Hub : Genes

Osbp2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC gene expression Osbp2 0.31 0.12 2.5e-05 0.26 0.18 0.17 0.2 8.9e-07 5.7e-05 6.4e-05 1.6e-05
2 Brain intron excision ratio chr14_82819546_82819817 0.07 0.04 5.3e-07 0.03 0.07 0.07 0.06 6.0e-04 2.9e-07 2.5e-07 2.3e-06
3 Brain mRNA stability Osbp2 0.06 0.03 8.1e-04 0.01 0.03 0.03 0.03 2.2e-02 7.6e-04 4.0e-04 2.1e-03
4 OFC mRNA stability Osbp2 0.18 0.1 5.0e-03 0.05 0.09 0.11 0.1 2.4e-02 3.5e-03 1.6e-03 2.4e-03
5 PL mRNA stability Osbp2 0.12 0.05 7.5e-06 0.02 0.06 0.06 0.04 6.1e-03 7.8e-07 3.1e-07 7.1e-05
6 NAcc isoform ratio XM_039092033.2 0.02 0.01 9.9e-03 0 0 0 0 1.9e-01 5.4e-02 3.4e-01 3.1e-01
7 IC intron excision ratio chr14_82819546_82819817 0.16 0.08 8.1e-04 0.08 0.07 0.11 0.08 3.3e-04 8.4e-04 2.6e-05 3.6e-04
8 Brain isoform ratio XM_039092033.2 0.05 0.03 2.8e-05 0.06 0.04 0.04 0.05 1.2e-06 1.2e-04 2.2e-04 1.3e-05
9 NAcc mRNA stability Osbp2 0.08 0.04 1.0e-06 0.04 0.05 0.04 0.04 1.2e-06 6.1e-08 1.7e-07 3.2e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.20.51.6-1.30.3-0.10.40.10.11.1-0.3-1.0
Area under the delay curve2.23.48.5-0.32.90.5-2.8-0.02.40.4-2.41.6
BMI with tail0.82.78.10.70.6-0.9-2.5-1.61.3-1.9-0.22.9
BMI without tail0.42.07.31.6-0.1-0.6-1.5-0.8-0.1-2.71.11.9
Body weight0.94.08.62.42.20.5-2.90.11.1-2.7-0.62.8
Weight adjusted by age0.20.72.01.40.90.1-1.00.30.3-1.2-0.30.9
Bone surface0.10.20.3-0.50.60.2-0.5-0.20.60.2-0.50.1
Bone volume0.10.20.5-0.70.50.40.00.20.30.5-0.4-0.4
Breakpoint value in progressive ratio session0.10.20.5-0.10.70.3-0.50.10.50.7-0.70.0
Number of licking bursts0.30.82.71.20.71.20.01.7-0.7-0.70.3-0.5
Context. condit. distance diff. score0.70.92.4-0.7-1.4-1.5-0.1-1.3-0.2-0.50.90.5
Locomotion velocity, session 10.40.41.0-0.5-0.90.50.6-0.50.01.0-0.6-0.7
Locomotion distance, session 10.30.30.9-0.8-0.6-0.90.1-0.90.00.20.50.0
Locomotion velocity, session 22.53.09.4-1.3-0.51.71.80.8-0.43.1-1.3-2.7
Locomotion distance, session 20.91.33.8-1.9-1.4-1.00.1-1.90.51.10.3-0.1
Locomotion velocity, session 30.50.62.0-0.8-0.4-1.4-0.5-1.30.50.00.00.6
Locomotion distance, session 30.20.30.6-0.20.10.1-0.7-0.70.70.4-0.80.4
Stereotopy head waving bouts, day 30.40.51.5-0.0-1.2-0.11.10.0-0.80.01.0-0.6
Stereotopy head waving duration, day 30.91.13.6-0.1-1.9-0.90.8-0.9-0.8-0.81.70.2
Locomotion velocity, session 70.20.30.90.1-0.11.00.30.10.00.8-0.6-0.6
Locomotion distance, session 70.50.71.9-1.4-0.4-0.6-0.4-1.30.80.8-0.60.3
Stereotopy head waving bouts, day 70.40.51.3-0.10.3-0.4-1.1-0.70.7-0.80.11.1
Stereotopy head waving duration, day 70.60.71.80.20.1-0.6-1.1-0.80.5-1.40.61.4
Locomotion velocity, session 80.91.13.0-0.8-1.70.21.5-0.4-0.81.00.4-1.4
Locomotion distance, session 81.92.78.2-1.3-2.9-2.10.8-2.1-0.8-0.32.1-0.0
Degree of sensitization distance0.91.02.6-0.7-1.6-0.71.5-0.3-1.00.21.1-0.8
Degree of sensitization stereotypy0.50.51.40.20.5-0.3-1.1-0.40.6-1.00.21.2
Conditioned locomotion1.61.93.5-1.40.4-1.8-1.8-1.91.3-0.50.01.7
Cocaine response after cond. corrected0.50.82.1-0.61.50.6-0.50.80.91.1-1.0-0.1
Cocaine response after cond. not corrected0.81.14.2-0.02.00.9-0.61.40.80.8-1.3-0.1
Cocaine response before conditioning0.30.31.21.10.20.40.20.7-0.6-0.4-0.1-0.3
Saline control response0.20.31.3-0.2-1.1-0.30.1-1.1-0.10.4-0.1-0.2
Bone: connectivity density0.20.31.2-1.10.2-0.6-0.1-0.40.40.6-0.3-0.2
Bone: cortical apparent density0.40.61.4-0.10.2-0.8-1.0-0.90.5-1.00.31.2
Bone: cortical area1.11.97.02.71.10.9-1.01.1-0.4-2.00.21.2
Bone: cortical porosity0.40.51.1-0.31.00.5-0.20.60.41.1-0.9-0.5
Bone: cortical porosity0.10.10.3-0.10.5-0.1-0.30.20.20.3-0.2-0.1
Bone: cortical thickness1.21.95.02.21.30.2-1.60.6-0.0-2.20.51.7
Bone: cortical thickness1.82.24.3-0.50.1-1.9-2.0-1.80.7-1.80.92.1
Bone: cortical tissue density0.30.51.4-0.20.3-0.7-1.0-0.80.6-0.90.21.2
Condit. Reinf. active minus inactive responses0.40.40.9-0.7-0.30.2-0.5-1.00.80.8-0.70.3
Condit. Reinf. active-inactive response ratio0.70.72.1-1.1-1.2-0.0-0.1-1.50.51.0-0.4-0.1
Condit. Reinf. active responses0.10.10.5-0.2-0.50.0-0.2-0.70.30.1-0.00.3
Condit. Reinf. inactive responses0.40.61.61.20.30.20.21.0-0.7-1.00.80.2
Incentive salience index mean0.20.30.6-0.10.20.5-0.8-0.60.70.5-0.80.4
Condit. Reinf. lever presses0.30.41.30.60.50.1-1.1-0.40.5-0.6-0.31.0
Condit. Reinf. active minus inactive responses0.50.71.71.1-1.2-0.20.7-0.0-1.3-0.80.7-0.5
Condit. Reinf. active-inactive response ratio0.20.40.8-0.50.1-0.6-0.9-0.90.60.0-0.60.5
Condit. Reinf. active responses0.40.62.50.3-1.6-0.40.8-0.6-1.10.00.4-0.7
Condit. Reinf. inactive responses0.60.93.30.3-1.8-0.31.2-0.4-1.20.01.0-0.8
Condit. Reinf. lever presses0.20.30.60.5-0.8-0.70.1-0.8-0.4-0.70.20.4
Condit. Reinf. lever reinforcers received0.30.41.60.2-1.3-0.70.2-1.0-0.6-0.10.1-0.2
Conditioned reinforcement - actives0.20.71.9-0.11.40.3-0.80.51.00.5-1.20.6
Conditioned reinforcement - inactives0.30.92.40.61.51.0-0.40.90.90.3-1.60.3
Conditioned locomotion0.40.61.70.61.31.1-0.01.20.1-0.2-0.8-0.2
Patch foraging indifference point 0 sec0.10.20.60.50.30.80.00.5-0.3-0.80.10.0
Patch foraging indifference point AUC0.30.61.5-0.2-1.01.10.8-0.3-0.21.2-0.4-1.0
Delay disc. indifference point, 0s delay6.47.216.9-1.73.2-1.5-4.1-1.73.6-0.3-2.33.3
Delay disc. indifference point, 16s delay1.82.55.5-0.72.31.2-1.70.71.82.0-2.40.2
Delay disc. indifference point, 2s delay2.93.28.0-0.42.8-0.5-2.8-0.12.4-0.2-1.82.0
Delay disc. indifference point, 24s delay2.43.87.9-1.62.6-0.2-2.8-0.62.71.2-2.41.5
Delay disc. indifference point, 4s delay1.61.75.20.12.30.5-1.70.41.50.3-1.80.9
Delay disc. indifference point, 8s delay0.20.40.60.60.80.8-0.80.00.5-0.3-0.70.5
Indifference point function ln k0.10.31.20.20.9-0.10.21.1-0.30.4-0.2-0.6
Indifference point function log k0.10.31.20.20.9-0.10.21.1-0.30.4-0.2-0.6
Patch foraging total patch changes 0 sec0.10.31.00.80.21.00.10.5-0.5-0.80.1-0.1
Patch foraging total patch changes 12 sec0.10.20.70.5-0.00.5-0.10.0-0.1-0.90.40.5
Patch foraging total patch changes 18 sec0.10.31.50.5-0.41.20.3-0.0-0.1-0.1-0.4-0.2
Patch foraging total patch changes 24 sec0.62.15.3-0.2-2.0-1.6-0.2-2.3-0.3-1.71.41.2
Patch foraging total patch changes 6 sec0.40.72.41.0-0.21.60.90.7-0.60.0-0.2-0.8
Patch foraging time to switch 0 sec0.83.17.6-0.2-0.3-2.4-1.3-1.50.5-2.81.82.6
Patch foraging water rate 0 sec1.03.78.22.5-0.22.91.92.5-1.90.6-0.6-2.2
Patch foraging water rate 12 sec0.31.33.41.8-0.81.11.51.0-1.5-0.20.1-1.1
Patch foraging water rate 18 sec1.02.35.02.2-0.6-0.21.41.6-2.2-1.71.7-0.6
Patch foraging water rate 24 sec3.34.710.53.2-1.71.42.72.1-3.0-1.31.3-1.5
Patch foraging water rate 6 sec2.23.29.63.1-0.91.51.81.8-2.5-1.20.8-1.4
Seeking ratio, delayed vs. immediate footshock1.72.58.2-0.20.11.71.11.2-0.62.9-1.1-2.6
Distance traveled before self-admin0.30.71.8-1.30.70.60.1-0.20.81.1-1.0-0.9
Distance traveled after self-admin0.50.82.2-1.51.2-0.2-0.5-0.31.30.7-1.00.1
Extensor digitorum longus weight0.83.47.62.72.42.7-0.42.5-0.2-1.2-1.20.3
Bone: elastic displacement0.50.71.91.0-0.5-0.50.30.3-1.0-1.41.30.0
Bone: elastic work1.72.36.42.5-0.20.10.51.4-1.7-2.31.90.1
Bone: endosteal estimation0.30.81.41.2-0.30.91.11.2-1.1-0.30.4-0.8
Bone: endosteal perimeter0.30.82.01.40.41.30.61.4-0.6-0.0-0.4-0.6
Epididymis fat weight0.31.33.10.61.6-0.1-1.70.01.0-1.2-0.21.7
Delta time in closed arm before/after self-admin1.61.56.0-1.7-0.6-2.5-0.7-1.80.50.00.30.7
Delta time in open arm before/after self-admin0.80.93.00.81.31.7-0.90.70.6-0.1-1.10.4
Diff in mean of infusions in LGA sessions0.91.63.2-1.80.5-1.2-1.5-1.61.60.6-0.90.9
Delay discount exponential model param2.33.17.70.2-2.8-0.52.7-0.0-2.3-0.32.2-1.5
Extinction: sum of active levers before priming1.42.14.8-1.71.60.1-1.6-0.41.81.5-2.20.4
Active lever presses in extinction session 61.71.73.2-1.51.8-0.6-1.5-0.51.80.9-1.70.7
Bone: final force0.91.45.11.9-0.40.1-0.20.3-0.9-2.31.41.0
Bone: final moment0.81.33.92.0-0.10.50.20.9-1.1-1.91.20.5
Food consumed during 24 hour testing period0.91.94.11.5-1.12.01.51.3-1.40.70.1-1.7
Glucose5.48.628.40.71.45.31.12.40.83.8-4.3-2.4
Heart weight0.10.10.40.50.30.6-0.10.30.0-0.1-0.70.1
Delay discount hyperbolic model param2.43.17.90.1-2.8-0.52.7-0.0-2.3-0.22.2-1.6
Intermittent access intake day 1-15 change0.10.51.7-0.60.70.7-0.00.30.71.0-1.30.0
Intermittent access intake escalation0.10.82.4-0.51.00.9-0.10.60.81.1-1.6-0.1
Intermittent access intake escalation 20.20.41.30.50.20.90.71.1-0.40.2-0.2-0.5
Intermitt. access day 1 inactive lever presses0.00.20.9-0.20.5-0.2-0.20.20.50.4-0.90.0
Intermitt. access day 15 inactive lever presses0.10.62.51.6-0.21.20.10.7-0.20.3-0.7-0.3
Intermitt. access escalation Index0.20.61.40.1-1.2-0.8-0.6-1.2-0.1-0.30.80.8
Intermittent access day 1 total infusions0.41.33.2-0.71.8-0.1-1.5-0.31.60.0-1.11.1
Intermittent access day 15 total infusions0.61.43.9-0.42.01.1-0.80.71.40.8-1.90.4
Intermittent access terminal intake (last 3 days)0.50.82.2-0.01.51.2-0.11.00.80.7-1.3-0.2
Intermittent access total infusions1.01.23.3-0.31.81.3-0.21.11.01.0-1.6-0.3
Intermittent access day 1 locomotion0.10.20.9-0.90.3-0.10.1-0.30.40.3-0.4-0.3
Intermittent access day 15 total locomotion0.20.92.70.61.60.5-1.20.40.9-0.6-1.01.0
Intermittent access total locomotion0.70.92.3-0.11.31.4-0.00.90.70.8-1.5-0.5
Intermittent access standard deviation0.00.00.20.30.1-0.00.20.2-0.0-0.4-0.10.1
Left kidney weight0.43.211.43.00.0-0.5-0.10.9-1.5-3.41.81.2
Right kidney weight0.43.011.41.91.0-1.6-1.40.1-0.4-3.41.62.1
Cocaine induced anxiety0.41.23.60.80.91.90.21.40.01.2-1.2-0.9
Post-drug Anxiety0.91.02.3-0.41.50.7-1.20.11.30.8-1.50.5
Baseline Anxiety1.52.53.9-2.00.8-1.6-1.9-1.91.9-0.5-0.42.0
Tail length0.52.97.62.51.32.50.72.8-1.2-0.90.1-1.1
Length with tail0.83.510.43.21.62.30.22.9-1.2-1.60.1-0.4
Length without tail0.20.92.51.21.60.6-0.71.20.2-0.9-0.60.7
Times rat made contact with spout1.11.33.6-0.0-1.21.31.10.2-0.71.7-0.6-1.9
Lifetime Intake1.11.43.4-0.21.81.50.11.40.81.1-1.6-0.6
Liver weight, left0.10.20.70.4-0.1-0.60.1-0.0-0.4-0.80.60.3
Liver weight, right1.01.85.81.2-1.0-1.1-0.1-0.8-0.9-2.41.91.1
Locomotor activity1.52.35.71.0-0.52.42.11.4-1.21.0-0.5-2.2
Locomotor testing distance0.20.61.41.10.71.10.51.2-0.3-0.0-0.3-0.4
Locomotor testing rearing0.41.33.41.11.01.80.71.8-0.20.7-1.0-1.0
Locomotion in novel chamber0.30.31.4-0.6-0.0-1.2-0.5-0.70.4-0.30.30.5
Locomotion in novel chamber post-restriction0.41.23.4-1.7-1.2-1.4-0.2-1.80.70.80.00.4
Fecal boli incidents, locomotor time 10.20.51.2-0.4-0.30.71.00.4-0.40.8-0.5-1.1
Change in fecal boli incidents, locomotor task0.30.31.2-0.0-1.10.30.6-0.3-0.50.50.3-0.7
Time >=10cm from walls, locomotor time 11.72.15.3-1.00.2-2.0-1.4-1.81.2-1.40.72.3
Bouts of movement, locomotor time 10.60.81.5-0.90.3-0.6-1.2-1.21.1-0.2-0.61.2
Total resting periods, locomotor time 10.81.02.1-0.80.2-0.8-1.4-1.41.2-0.3-0.61.3
Rest time, locomotor task time 10.10.10.40.5-0.70.30.3-0.1-0.4-0.40.0-0.3
Distance moved, locomotor task time 10.10.20.60.30.00.50.30.5-0.4-0.30.8-0.2
Vertical activity count, locomotor time 10.10.41.1-1.00.10.50.60.20.11.00.0-0.9
Time >=10cm from walls, locomotor time 20.10.30.8-0.9-0.1-0.6-0.1-0.90.3-0.3-0.10.4
Bouts of movement, locomotor time 20.10.31.00.10.2-0.7-0.5-0.60.6-0.3-0.41.0
Total resting periods, locomotor time 20.10.51.40.00.1-0.7-0.8-1.00.7-0.4-0.51.2
Rest time, locomotor task time 20.10.20.90.4-0.90.00.2-0.4-0.6-0.50.6-0.2
Distance moved, locomotor task time 20.10.10.3-0.2-0.0-0.4-0.2-0.0-0.0-0.30.60.3
Vertical activity count, locomotor time 20.30.62.0-1.40.7-0.0-0.30.00.81.2-0.7-0.3
Light reinforcement 10.20.93.71.60.20.10.10.8-0.6-1.90.80.8
Light reinforcement 20.71.75.32.0-0.60.20.70.6-1.4-2.31.60.4
Bone: marrow area0.20.51.01.0-0.30.71.01.0-0.9-0.30.4-0.7
Bone: maximum diameter1.22.39.23.00.92.30.12.0-0.8-1.0-0.40.1
Bone: maximum force0.81.64.62.1-0.50.20.20.6-1.2-2.11.60.6
Bone: maximum moment0.91.75.02.2-0.20.60.61.3-1.5-1.81.4-0.0
Mean time between licks in bursts0.31.54.40.3-1.11.51.41.0-1.21.30.0-2.1
Mean num. licks in bursts0.41.23.2-1.2-1.5-0.30.7-1.40.31.8-0.6-0.8
Cd content in liver0.20.21.00.3-0.21.00.30.3-0.2-0.00.1-0.4
Co content in liver0.20.30.80.10.90.5-0.40.30.50.2-0.80.2
Cu content in liver0.70.81.6-1.30.9-0.4-0.9-0.51.31.0-1.00.4
Fe content in liver1.61.95.9-2.4-0.3-1.7-0.6-1.81.41.3-0.90.5
K content in liver2.82.88.7-1.33.0-0.1-1.70.42.20.9-2.21.1
Mg content in liver1.31.45.1-0.12.30.2-1.40.51.30.0-1.51.0
Mn content in liver0.40.41.3-0.50.80.70.10.40.31.1-0.7-0.7
Na content in liver3.53.99.9-1.72.60.8-1.9-0.02.62.2-3.10.4
Rb content in liver0.30.30.80.00.90.4-0.80.00.7-0.0-0.60.6
Se content in liver1.21.45.8-0.12.40.6-0.71.30.91.0-1.7-0.2
Sr content in liver0.90.82.81.70.41.50.01.1-0.6-0.2-0.4-0.4
Zn content in liver0.70.81.91.40.11.00.81.3-1.2-0.60.5-0.7
Bone: minimum diameter0.40.72.41.5-0.50.20.80.7-1.2-0.90.7-0.3
Time in familiar zone, hab. session 10.60.72.0-0.2-1.4-0.70.5-0.7-0.5-0.71.40.0
Time in novel zone, hab. session 10.70.82.10.81.21.00.21.5-0.30.4-0.9-0.7
Total zone transitions, hab. session 10.20.31.2-0.4-1.10.10.4-0.8-0.20.20.3-0.4
Total locomotion distance, hab. session 10.30.41.6-0.8-0.00.50.3-0.10.31.3-0.8-0.8
Locomotion velocity, hab. session 10.20.30.9-0.8-0.30.10.1-0.50.41.0-0.6-0.2
Time in familiar zone, hab. session 21.11.34.6-1.2-1.2-2.10.0-1.40.0-0.41.20.6
Time in novel zone, hab. session 21.71.95.82.40.42.30.61.7-1.0-0.6-0.2-0.7
Total zone transitions, hab. session 20.20.20.80.5-0.60.90.3-0.2-0.3-0.20.3-0.1
Total locomotion distance, hab. session 20.40.51.90.9-0.61.40.80.5-0.50.10.2-0.6
Locomotion velocity, hab. session 20.30.32.00.6-0.11.40.40.4-0.20.3-0.2-0.4
Novel to familiar place preference ratio1.01.34.3-0.71.00.7-1.3-0.71.41.2-2.10.3
Novelty place preference0.81.03.8-0.40.90.9-1.0-0.31.11.2-2.00.1
Time in novel zone, NPP test0.60.83.1-0.10.71.0-0.8-0.20.81.0-1.8-0.0
Total zone transitions, NPP test0.10.20.4-0.40.2-0.6-0.5-0.60.4-0.10.00.6
Total locomotion distance, NPP test0.30.40.8-0.80.6-0.3-0.6-0.50.90.7-0.70.4
Locomotion velocity, NPP test0.60.91.7-1.31.0-0.3-0.9-0.61.31.0-1.10.5
Intraocular pressure0.40.62.40.8-1.50.40.2-0.9-0.5-0.70.90.3
Delta distance traveled before/after self-admin0.60.71.9-0.50.5-1.2-1.0-0.60.9-0.5-0.11.4
Delta ambulatory time before/after self-admin0.30.51.1-1.10.5-1.1-0.6-0.50.80.1-0.20.8
Parametrial fat weight0.61.43.1-0.5-0.31.4-1.2-1.61.41.2-1.70.3
Pavlov. Cond. lever latency0.40.51.0-0.40.50.60.61.00.00.9-0.7-0.9
Pavlov. Cond. magazine entry latency0.50.62.30.0-1.5-0.40.4-1.0-0.7-0.01.0-0.5
Pavlov. Cond. change in total contacts0.40.51.1-0.20.30.8-1.0-0.90.80.5-0.70.3
Pavlov. Cond. index score0.50.62.4-0.4-1.0-1.0-0.5-1.60.0-0.20.70.4
Pavlov. Cond. latency score0.50.62.1-0.2-1.0-0.9-0.4-1.5-0.2-0.51.00.5
Pavlov. Cond. lever contacts0.40.51.60.1-0.7-0.8-0.6-1.3-0.0-0.80.80.8
Pavlov. Cond. magazine entry number0.50.62.50.71.30.50.11.6-0.0-0.6-0.30.3
Pavlov. Cond. intertrial magazine entries0.30.41.90.11.4-0.1-0.50.70.4-0.3-0.50.5
Pavlov. Cond. lever-magazine prob. diff.0.50.62.3-0.4-1.0-1.0-0.5-1.5-0.1-0.30.80.4
Pavlov. Cond. response bias0.20.21.1-0.5-0.3-0.3-0.5-1.10.30.4-0.00.1
Pavlov. Cond. lever latency0.60.83.40.21.90.6-0.71.40.6-0.4-0.10.4
Pavlov. Cond. magazine entry latency0.10.10.50.4-0.0-0.1-0.5-0.3-0.0-0.7-0.10.5
Pavlov. Cond. change in total contacts0.10.31.20.1-1.1-0.60.1-1.1-0.2-0.30.10.3
Pavlov. Cond. index score0.20.31.30.1-1.1-0.60.2-1.0-0.4-0.30.10.1
Pavlov. Cond. latency score0.20.31.30.1-1.2-0.60.2-1.0-0.4-0.30.20.1
Pavlov. Cond. lever contacts0.50.82.8-0.6-1.7-0.90.5-1.5-0.30.6-0.0-0.3
Pavlov. Cond. magazine entry number0.30.31.0-1.00.6-0.1-0.2-0.10.80.9-0.4-0.1
Pavlov. Cond. intertrial magazine entries0.10.31.3-0.60.30.10.30.20.31.1-0.5-0.5
Pavlov. Cond. lever-magazine prob. diff.0.20.41.40.1-1.2-0.60.2-1.0-0.4-0.40.30.1
Pavlov. Cond. response bias0.30.41.4-0.3-1.2-0.60.2-1.2-0.20.2-0.1-0.0
Time in closed arm before self-admin0.91.53.41.8-0.70.20.91.2-1.7-1.21.8-0.4
Time in closed arm after self-admin0.70.82.40.2-0.9-1.50.1-0.1-1.0-0.61.50.1
Time in open arm before self-admin0.00.00.1-0.2-0.1-0.10.1-0.20.1-0.30.10.1
Time in open arm after self-admin0.20.20.60.20.30.8-0.4-0.20.5-0.3-0.70.5
Bone: periosteal estimation0.51.35.22.30.31.00.21.3-1.0-1.50.50.2
Bone: periosteal perimeter0.51.03.92.01.10.9-0.71.0-0.1-1.1-0.40.8
Bone: post-yield work0.30.61.50.0-0.00.91.10.9-0.50.8-0.3-1.2
Progressive ratio test 1 active lever presses1.42.46.1-1.62.20.9-0.80.51.81.8-2.5-0.2
Progressive ratio test 1 breakpoint1.42.46.1-1.62.20.8-0.90.41.81.8-2.5-0.1
Progressive ratio test 1 inactive lever presses0.71.85.0-0.41.81.7-0.70.91.31.3-2.2-0.2
Progressive ratio test 2 active lever presses0.50.61.7-0.31.30.9-0.60.60.90.6-1.10.2
Progressive ratio test 2 breakpoint0.40.51.4-0.21.20.8-0.50.50.90.5-1.00.3
Progressive ratio test 2 inactive lever presses0.20.81.31.21.00.9-0.90.60.7-0.6-0.71.1
Incentive Sensitization - Responses0.10.30.80.70.10.2-0.60.00.2-0.80.40.9
Incentive Sensitization - Breakpoint0.20.41.00.9-0.10.1-0.50.10.0-1.00.60.9
Sum of active levers in priming session hrs 5-61.51.42.7-1.11.7-0.8-1.6-0.51.50.5-1.30.9
Progressive ratio0.00.00.10.20.30.3-0.20.3-0.10.10.1-0.2
Food seeking constrained by brief footshock0.70.93.10.31.81.0-1.20.50.8-0.3-1.00.4
Seeking ratio, punishment vs. effort0.10.10.30.60.50.4-0.10.40.1-0.2-0.40.2
Retroperitoneal fat weight0.31.44.10.2-0.6-0.1-1.6-2.01.2-0.8-0.21.9
Reaction time number correct1.13.77.62.0-1.71.72.81.9-2.50.11.0-2.3
Reaction time mean minus median0.10.31.3-0.60.40.30.10.50.31.1-0.8-0.5
Reaction time mean minus median AUC0.00.10.30.20.5-0.1-0.40.20.3-0.1-0.50.5
Reaction time num false alarms1.11.94.9-0.41.2-1.0-2.2-1.31.6-1.0-0.52.1
Reaction time num false alarms AUC0.92.05.3-0.11.0-1.3-2.1-1.31.3-1.60.02.3
Reaction time trials correct on left1.13.77.62.0-1.71.72.81.9-2.50.11.0-2.3
Reaction time trials on left1.13.77.82.0-1.71.72.81.9-2.50.11.0-2.3
Reaction time mean0.20.51.6-1.30.7-0.8-0.5-0.20.80.7-0.50.3
Reaction time mean AUC0.20.41.3-1.10.6-0.9-0.4-0.10.70.6-0.40.4
Median of all reaction times0.40.62.0-1.40.6-1.1-0.6-0.40.90.5-0.30.6
Reaction time omissions0.10.10.5-0.5-0.4-0.70.2-0.40.20.4-0.10.0
Reaction time false alarm rate3.34.510.8-0.91.8-2.0-3.3-1.92.4-1.5-0.53.2
Reaction time premature initiation rate1.32.04.3-0.2-1.8-2.10.0-1.7-0.5-1.61.90.9
Reaction time premature initiations0.62.05.40.8-2.3-0.71.5-0.5-1.7-1.22.1-0.4
Std. dev. reaction times0.00.10.4-0.60.2-0.3-0.2-0.00.50.4-0.40.3
Reaction time trials completed1.13.77.82.0-1.71.72.81.9-2.50.11.0-2.3
Reaction time trials AUC1.13.87.82.0-1.51.92.82.1-2.50.30.9-2.4
Run reversals in cocaine runway, females2.62.95.4-2.30.4-2.3-1.9-2.21.9-0.1-0.01.9
Run reversals in cocaine runway, males0.10.10.30.5-0.20.3-0.10.2-0.5-0.30.3-0.3
Latency to leave start box in cocaine runway0.50.71.4-0.80.7-0.6-1.2-1.11.0-0.1-0.80.4
Latency to leave start box in cocaine runway, F0.70.92.40.70.5-0.8-1.6-0.90.4-1.40.21.2
Latency to leave start box in cocaine runway, M1.21.22.9-1.70.60.30.1-0.41.11.6-1.7-0.8
Std. dev. time between licks in bursts0.20.30.9-0.3-1.00.10.2-0.3-0.60.40.5-0.9
Total sessions with >9 infusions0.10.10.2-0.30.1-0.20.40.00.20.3-0.4-0.4
Short access day 1 total inactive lever presses0.61.35.01.40.82.20.41.5-0.20.2-0.8-0.9
Short access day 10 total inactive lever presses0.21.23.31.8-0.60.91.21.4-1.3-0.10.3-1.0
Short access day 1 total infusions0.00.10.2-0.20.4-0.30.20.30.30.2-0.10.0
Short access day 10 total infusions0.10.20.8-0.90.20.10.4-0.10.40.4-0.5-0.3
Short access total infusions0.30.40.6-0.20.80.70.60.80.30.7-0.7-0.6
Short access day 1 locomotion0.40.61.40.4-0.80.11.20.5-1.1-0.40.8-0.9
Short access day 10 total locomotion0.31.13.6-1.0-1.10.11.6-0.1-0.71.1-0.0-1.9
Short access total locomotion0.81.23.5-0.1-1.50.21.90.0-1.30.30.6-1.8
One hour access (0.3 mA shock)1.01.12.4-0.81.41.20.10.90.91.4-1.5-0.6
Compulsive drug intake0.91.44.2-2.1-0.5-2.0-0.6-1.70.60.40.20.3
One hour access (shock baseline)0.82.24.4-0.02.12.00.11.80.91.5-2.1-0.7
Social response proportion1.01.33.10.8-0.91.81.31.2-1.20.60.3-1.3
Social responses1.21.53.61.1-1.01.91.41.4-1.20.70.3-1.4
Social time0.30.50.8-0.3-0.90.10.90.5-0.70.80.7-0.8
Soleus weight1.44.212.63.60.52.11.32.9-2.3-1.91.0-1.0
Bone: stiffness0.40.61.8-0.1-0.1-0.9-0.9-1.10.5-0.80.41.4
Tibialis anterior weight0.41.43.21.71.51.8-0.41.5-0.1-0.8-1.00.1
Time to tail flick, vehicle, before self-admin0.60.82.10.1-0.1-1.0-1.0-0.80.4-1.20.91.4
Time to tail flick, vehicle, after self-admin0.71.53.3-1.80.2-1.3-1.1-1.61.60.9-1.00.6
Time to tail flick, test, before self-admin0.30.40.70.8-0.50.00.80.5-0.80.30.4-0.7
Time to tail flick, test, after self-admin2.22.46.12.50.12.21.12.1-1.50.10.1-1.5
Delta time to tail flick, vehicle, before/after SA1.11.23.2-1.80.2-0.3-0.1-1.01.11.6-1.5-0.6
Delta time to tail flick, test, before/after SA0.50.62.21.00.31.50.51.0-0.5-0.1-0.3-0.7
Tibia length0.51.34.70.7-0.0-1.3-0.6-0.3-0.4-2.21.81.1
Ambulatory time before self-admin0.41.12.9-1.71.20.4-0.4-0.21.21.3-1.3-0.5
Ambulatory time after self-admin1.01.65.5-2.31.3-0.2-0.6-0.41.61.5-1.4-0.1
Bone: tissue strength2.72.85.32.1-1.20.92.21.7-2.3-0.81.8-1.3
Total heroin consumption0.10.10.30.3-0.00.20.50.5-0.50.20.2-0.4
Bone: trabecular number0.10.20.7-0.80.7-0.30.10.30.20.5-0.2-0.4
Bone: trabecular spacing0.40.62.41.6-0.51.00.40.5-0.6-0.70.4-0.1
Bone: trabecular thickness0.20.31.4-1.20.3-0.90.3-0.0-0.00.20.3-0.2
Bone: trabecular tissue density0.20.40.9-0.9-0.2-0.6-0.4-0.90.60.6-0.20.3
Water consumed over 24 hours1.42.76.30.9-1.62.02.01.3-1.91.10.5-2.5
Number of responses in last shaping day1.11.42.5-1.50.1-1.2-1.3-1.61.60.6-0.71.3