Osbp2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	OFC	gene expression	Osbp2	0.31	0.12	2.5e-05	0.26	0.18	0.17	0.2	8.9e-07	5.7e-05	6.4e-05	1.8e-05
2	Brain	intron excision ratio	chr14_82819546_82819817	0.07	0.04	5.3e-07	0.03	0.07	0.07	0.06	6.0e-04	2.9e-07	2.5e-07	2.3e-06
3	Brain	mRNA stability	Osbp2	0.06	0.03	8.1e-04	0.01	0.03	0.03	0.03	2.2e-02	7.6e-04	4.0e-04	2.0e-03
4	OFC	mRNA stability	Osbp2	0.18	0.1	5.0e-03	0.05	0.09	0.11	0.1	2.4e-02	3.5e-03	1.6e-03	2.6e-03
5	PL	mRNA stability	Osbp2	0.12	0.05	7.5e-06	0.02	0.06	0.06	0.04	6.1e-03	7.8e-07	3.1e-07	7.0e-05
6	NAcc	isoform ratio	XM_039092033.2	0.02	0.01	9.9e-03	0	0	0	0	1.9e-01	5.4e-02	3.4e-01	3.0e-01
7	IC	intron excision ratio	chr14_82819546_82819817	0.16	0.08	8.1e-04	0.08	0.07	0.11	0.08	3.3e-04	8.4e-04	2.6e-05	3.4e-04
8	Brain	isoform ratio	XM_039092033.2	0.05	0.03	2.8e-05	0.06	0.04	0.04	0.05	1.2e-06	1.2e-04	2.2e-04	1.3e-05
9	NAcc	mRNA stability	Osbp2	0.08	0.04	1.0e-06	0.04	0.05	0.04	0.04	1.2e-06	6.1e-08	1.7e-07	2.7e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	0.3	0.5	1.6	1.3	-0.3	0.1	-0.4	-0.2	0.1	-1.1	0.3	-1.0
Area under the delay curve	2.9	3.4	8.5	0.3	-2.9	-0.5	2.8	0.0	2.4	-0.4	2.4	1.6
BMI with tail	0.8	2.7	8.1	-0.7	-0.6	0.9	2.5	1.6	1.3	1.9	0.2	2.9
BMI without tail	0.7	2.0	7.3	-1.6	0.1	0.6	1.5	0.9	-0.1	2.7	-1.1	1.9
Body weight	0.9	4.0	8.6	-2.4	-2.2	-0.5	2.9	-0.1	1.1	2.7	0.6	2.8
Weight adjusted by age	0.5	0.7	2.0	-1.4	-0.9	-0.1	1.0	-0.3	0.3	1.2	0.3	0.9
Bone surface	0.1	0.2	0.3	0.5	-0.6	-0.2	0.5	0.2	0.6	-0.2	0.5	0.1
Bone volume	0.1	0.2	0.5	0.7	-0.5	-0.4	-0.0	-0.2	0.3	-0.5	0.4	-0.4
Breakpoint value in progressive ratio session	0.2	0.2	0.5	0.1	-0.7	-0.3	0.5	-0.1	0.5	-0.7	0.7	0.0
Number of licking bursts	0.5	0.8	2.7	-1.2	-0.7	-1.2	-0.0	-1.7	-0.7	0.7	-0.3	-0.5
Context. condit. distance diff. score	0.7	0.9	2.4	0.7	1.4	1.5	0.1	1.3	-0.2	0.5	-0.9	0.5
Locomotion velocity, session 1	0.4	0.4	1.0	0.5	0.9	-0.5	-0.6	0.5	0.0	-1.0	0.6	-0.7
Locomotion distance, session 1	0.3	0.3	0.9	0.8	0.6	0.9	-0.1	0.9	0.0	-0.2	-0.5	0.0
Locomotion velocity, session 2	2.6	3.1	9.4	1.3	0.5	-1.7	-1.8	-0.9	-0.4	-3.1	1.3	-2.7
Locomotion distance, session 2	0.9	1.3	3.7	1.9	1.4	1.0	-0.1	1.9	0.5	-1.1	-0.3	-0.1
Locomotion velocity, session 3	0.5	0.6	2.0	0.8	0.4	1.4	0.5	1.3	0.5	-0.0	-0.0	0.6
Locomotion distance, session 3	0.3	0.3	0.6	0.2	-0.1	-0.1	0.7	0.7	0.7	-0.4	0.8	0.4
Stereotopy head waving bouts, day 3	0.4	0.5	1.5	0.0	1.2	0.1	-1.1	-0.0	-0.8	-0.0	-1.0	-0.6
Stereotopy head waving duration, day 3	0.9	1.1	3.6	0.1	1.9	0.9	-0.8	0.9	-0.8	0.8	-1.7	0.2
Locomotion velocity, session 7	0.2	0.3	0.9	-0.1	0.1	-1.0	-0.3	-0.1	0.0	-0.8	0.6	-0.6
Locomotion distance, session 7	0.5	0.7	1.9	1.4	0.4	0.6	0.4	1.3	0.8	-0.8	0.6	0.3
Stereotopy head waving bouts, day 7	0.4	0.5	1.3	0.1	-0.3	0.4	1.1	0.7	0.7	0.8	-0.1	1.1
Stereotopy head waving duration, day 7	0.6	0.7	1.8	-0.2	-0.1	0.6	1.1	0.8	0.5	1.4	-0.6	1.4
Locomotion velocity, session 8	0.9	1.1	3.0	0.8	1.7	-0.2	-1.5	0.3	-0.8	-1.0	-0.4	-1.4
Locomotion distance, session 8	1.9	2.7	8.2	1.3	2.9	2.1	-0.8	2.1	-0.8	0.3	-2.1	-0.0
Degree of sensitization distance	0.9	1.0	2.6	0.7	1.6	0.7	-1.5	0.2	-1.0	-0.2	-1.1	-0.8
Degree of sensitization stereotypy	0.5	0.5	1.4	-0.2	-0.5	0.3	1.1	0.4	0.6	1.0	-0.2	1.2
Conditioned locomotion	1.6	1.9	3.5	1.4	-0.4	1.8	1.8	1.9	1.3	0.5	-0.0	1.7
Cocaine response after cond. corrected	0.6	0.8	2.1	0.6	-1.5	-0.6	0.5	-0.8	0.9	-1.1	1.0	-0.1
Cocaine response after cond. not corrected	1.0	1.1	4.2	0.0	-2.0	-0.9	0.6	-1.4	0.8	-0.8	1.3	-0.1
Cocaine response before conditioning	0.3	0.3	1.2	-1.1	-0.2	-0.4	-0.2	-0.7	-0.6	0.4	0.1	-0.3
Saline control response	0.2	0.3	1.3	0.2	1.1	0.3	-0.1	1.1	-0.1	-0.4	0.1	-0.2
Bone: connectivity density	0.2	0.3	1.2	1.1	-0.2	0.6	0.1	0.4	0.4	-0.6	0.3	-0.2
Bone: cortical apparent density	0.4	0.6	1.4	0.1	-0.2	0.8	1.0	0.9	0.5	1.0	-0.3	1.2
Bone: cortical area	1.2	1.9	7.0	-2.7	-1.1	-0.9	1.0	-1.1	-0.4	2.0	-0.2	1.2
Bone: cortical porosity	0.4	0.5	1.1	0.3	-1.0	-0.5	0.2	-0.6	0.4	-1.1	0.9	-0.5
Bone: cortical porosity	0.1	0.1	0.3	0.1	-0.5	0.1	0.3	-0.2	0.2	-0.3	0.2	-0.1
Bone: cortical thickness	1.2	1.9	5.0	-2.2	-1.3	-0.2	1.6	-0.5	-0.0	2.2	-0.5	1.7
Bone: cortical thickness	1.9	2.2	4.3	0.5	-0.1	1.9	2.0	1.8	0.7	1.8	-0.9	2.1
Bone: cortical tissue density	0.4	0.5	1.4	0.2	-0.3	0.7	1.0	0.8	0.6	0.9	-0.2	1.2
Condit. Reinf. active minus inactive responses	0.4	0.4	0.9	0.7	0.3	-0.2	0.5	1.0	0.8	-0.8	0.7	0.3
Condit. Reinf. active-inactive response ratio	0.7	0.7	2.1	1.1	1.2	0.0	0.1	1.5	0.5	-1.0	0.4	-0.1
Condit. Reinf. active responses	0.1	0.1	0.5	0.2	0.5	-0.0	0.2	0.7	0.3	-0.1	0.0	0.3
Condit. Reinf. inactive responses	0.5	0.6	1.6	-1.2	-0.3	-0.2	-0.2	-1.0	-0.7	1.0	-0.8	0.2
Incentive salience index mean	0.3	0.3	0.6	0.1	-0.2	-0.5	0.8	0.6	0.7	-0.5	0.8	0.4
Condit. Reinf. lever presses	0.3	0.4	1.3	-0.6	-0.5	-0.1	1.1	0.4	0.5	0.6	0.3	1.0
Condit. Reinf. active minus inactive responses	0.5	0.7	1.7	-1.1	1.2	0.2	-0.7	0.0	-1.3	0.8	-0.7	-0.5
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.8	0.5	-0.1	0.6	0.9	0.9	0.6	-0.0	0.6	0.5
Condit. Reinf. active responses	0.4	0.6	2.5	-0.3	1.6	0.4	-0.8	0.6	-1.1	-0.0	-0.4	-0.7
Condit. Reinf. inactive responses	0.7	0.9	3.3	-0.3	1.8	0.3	-1.2	0.4	-1.2	-0.0	-1.0	-0.8
Condit. Reinf. lever presses	0.2	0.3	0.6	-0.5	0.8	0.7	-0.1	0.8	-0.4	0.7	-0.2	0.4
Condit. Reinf. lever reinforcers received	0.3	0.4	1.6	-0.2	1.3	0.7	-0.2	1.0	-0.6	0.1	-0.1	-0.2
Conditioned reinforcement - actives	0.4	0.7	1.9	0.1	-1.4	-0.3	0.8	-0.5	1.0	-0.5	1.2	0.6
Conditioned reinforcement - inactives	0.6	0.9	2.4	-0.6	-1.5	-1.0	0.4	-0.9	0.9	-0.3	1.6	0.3
Conditioned locomotion	0.5	0.6	1.7	-0.6	-1.3	-1.1	0.0	-1.2	0.1	0.2	0.8	-0.2
Patch foraging indifference point 0 sec	0.1	0.2	0.6	-0.5	-0.3	-0.8	-0.0	-0.5	-0.3	0.8	-0.1	0.0
Patch foraging indifference point AUC	0.4	0.6	1.5	0.2	1.0	-1.1	-0.8	0.3	-0.2	-1.2	0.4	-1.0
Delay disc. indifference point, 0s delay	6.6	7.2	16.8	1.7	-3.2	1.5	4.1	1.7	3.6	0.3	2.3	3.3
Delay disc. indifference point, 16s delay	2.3	2.5	5.5	0.7	-2.3	-1.2	1.7	-0.7	1.8	-2.0	2.4	0.2
Delay disc. indifference point, 2s delay	2.9	3.2	8.0	0.4	-2.8	0.5	2.8	0.1	2.4	0.2	1.8	2.0
Delay disc. indifference point, 24s delay	3.4	3.8	7.9	1.6	-2.6	0.2	2.8	0.7	2.7	-1.2	2.4	1.5
Delay disc. indifference point, 4s delay	1.6	1.7	5.2	-0.1	-2.3	-0.5	1.7	-0.4	1.5	-0.3	1.8	0.9
Delay disc. indifference point, 8s delay	0.3	0.4	0.6	-0.6	-0.8	-0.8	0.8	-0.0	0.5	0.3	0.7	0.5
Indifference point function ln k	0.2	0.3	1.3	-0.2	-0.9	0.1	-0.2	-1.1	-0.3	-0.4	0.2	-0.6
Indifference point function log k	0.2	0.3	1.3	-0.2	-0.9	0.1	-0.2	-1.1	-0.3	-0.4	0.2	-0.6
Patch foraging total patch changes 0 sec	0.2	0.3	1.0	-0.8	-0.2	-1.0	-0.1	-0.5	-0.5	0.8	-0.1	-0.1
Patch foraging total patch changes 12 sec	0.2	0.2	0.7	-0.5	0.0	-0.5	0.1	-0.0	-0.1	0.9	-0.4	0.5
Patch foraging total patch changes 18 sec	0.2	0.3	1.5	-0.5	0.4	-1.2	-0.3	0.0	-0.1	0.1	0.4	-0.2
Patch foraging total patch changes 24 sec	1.2	2.1	5.3	0.2	2.0	1.6	0.2	2.3	-0.3	1.7	-1.4	1.2
Patch foraging total patch changes 6 sec	0.4	0.7	2.4	-1.0	0.2	-1.6	-0.9	-0.7	-0.6	-0.0	0.2	-0.8
Patch foraging time to switch 0 sec	1.5	3.1	7.6	0.2	0.3	2.4	1.3	1.6	0.5	2.8	-1.8	2.6
Patch foraging water rate 0 sec	1.8	3.7	8.2	-2.5	0.2	-2.9	-1.9	-2.5	-1.9	-0.6	0.6	-2.2
Patch foraging water rate 12 sec	0.6	1.3	3.4	-1.8	0.8	-1.1	-1.5	-1.0	-1.5	0.2	-0.1	-1.1
Patch foraging water rate 18 sec	1.5	2.3	5.0	-2.2	0.6	0.2	-1.4	-1.6	-2.2	1.7	-1.7	-0.6
Patch foraging water rate 24 sec	3.3	4.7	10.5	-3.2	1.7	-1.4	-2.7	-2.1	-3.0	1.3	-1.3	-1.5
Patch foraging water rate 6 sec	2.2	3.2	9.6	-3.1	0.9	-1.5	-1.8	-1.8	-2.5	1.2	-0.8	-1.4
Seeking ratio, delayed vs. immediate footshock	2.0	2.5	8.2	0.2	-0.1	-1.7	-1.1	-1.3	-0.6	-2.9	1.1	-2.6
Distance traveled before self-admin	0.5	0.7	1.8	1.3	-0.7	-0.6	-0.1	0.2	0.8	-1.1	1.0	-0.9
Distance traveled after self-admin	0.7	0.8	2.2	1.5	-1.2	0.2	0.5	0.3	1.3	-0.7	1.0	0.1
Extensor digitorum longus weight	0.9	3.3	7.6	-2.7	-2.4	-2.7	0.4	-2.5	-0.2	1.2	1.2	0.3
Bone: elastic displacement	0.6	0.7	1.9	-1.0	0.5	0.5	-0.3	-0.3	-1.0	1.4	-1.3	0.0
Bone: elastic work	1.7	2.3	6.4	-2.5	0.2	-0.1	-0.5	-1.4	-1.7	2.3	-1.9	0.1
Bone: endosteal estimation	0.4	0.8	1.4	-1.2	0.3	-0.9	-1.1	-1.2	-1.1	0.3	-0.4	-0.8
Bone: endosteal perimeter	0.4	0.8	1.9	-1.4	-0.4	-1.3	-0.6	-1.4	-0.6	0.0	0.4	-0.6
Epididymis fat weight	0.4	1.3	3.1	-0.6	-1.6	0.1	1.7	-0.0	1.0	1.2	0.2	1.7
Delta time in closed arm before/after self-admin	1.7	1.5	6.0	1.7	0.6	2.5	0.7	1.8	0.5	-0.0	-0.3	0.7
Delta time in open arm before/after self-admin	0.9	0.9	3.0	-0.8	-1.3	-1.7	0.9	-0.7	0.6	0.1	1.1	0.4
Diff in mean of infusions in LGA sessions	1.3	1.6	3.2	1.8	-0.5	1.2	1.5	1.6	1.6	-0.6	0.9	0.9
Delay discount exponential model param	2.8	3.1	7.7	-0.2	2.8	0.5	-2.7	0.0	-2.3	0.3	-2.2	-1.5
Extinction: sum of active levers before priming	1.9	2.1	4.8	1.7	-1.6	-0.1	1.6	0.4	1.8	-1.5	2.2	0.4
Active lever presses in extinction session 6	1.7	1.7	3.2	1.5	-1.8	0.6	1.5	0.5	1.8	-0.9	1.7	0.7
Bone: final force	0.9	1.4	5.1	-1.9	0.4	-0.1	0.2	-0.3	-0.9	2.3	-1.4	1.0
Bone: final moment	0.8	1.3	3.9	-2.0	0.1	-0.5	-0.2	-0.9	-1.1	1.9	-1.2	0.5
Food consumed during 24 hour testing period	1.4	1.9	4.1	-1.5	1.1	-2.0	-1.5	-1.3	-1.4	-0.7	-0.1	-1.7
Glucose	5.5	8.6	28.4	-0.7	-1.4	-5.3	-1.1	-2.4	0.8	-3.8	4.3	-2.4
Heart weight	0.1	0.1	0.4	-0.5	-0.3	-0.6	0.1	-0.3	0.0	0.1	0.7	0.1
Delay discount hyperbolic model param	2.8	3.1	7.9	-0.1	2.8	0.5	-2.7	0.0	-2.3	0.2	-2.2	-1.6
Intermittent access intake day 1-15 change	0.3	0.5	1.7	0.6	-0.7	-0.7	0.0	-0.3	0.7	-1.0	1.3	0.0
Intermittent access intake escalation	0.4	0.8	2.4	0.5	-1.0	-0.9	0.1	-0.6	0.8	-1.1	1.6	-0.1
Intermittent access intake escalation 2	0.3	0.4	1.3	-0.5	-0.2	-0.9	-0.7	-1.1	-0.4	-0.2	0.2	-0.5
Intermitt. access day 1 inactive lever presses	0.0	0.2	0.9	0.2	-0.5	0.2	0.2	-0.2	0.5	-0.4	0.9	0.0
Intermitt. access day 15 inactive lever presses	0.3	0.6	2.5	-1.6	0.2	-1.2	-0.1	-0.7	-0.2	-0.3	0.7	-0.3
Intermitt. access escalation Index	0.4	0.6	1.4	-0.1	1.2	0.8	0.6	1.2	-0.1	0.3	-0.8	0.8
Intermittent access day 1 total infusions	0.8	1.3	3.2	0.7	-1.8	0.1	1.5	0.3	1.6	-0.0	1.1	1.1
Intermittent access day 15 total infusions	1.0	1.4	3.9	0.4	-2.0	-1.1	0.8	-0.7	1.4	-0.8	1.9	0.4
Intermittent access terminal intake (last 3 days)	0.6	0.8	2.2	0.0	-1.5	-1.2	0.1	-1.0	0.8	-0.7	1.3	-0.2
Intermittent access total infusions	1.0	1.2	3.3	0.3	-1.8	-1.3	0.2	-1.1	1.0	-1.0	1.6	-0.3
Intermittent access day 1 locomotion	0.1	0.2	0.9	0.9	-0.3	0.1	-0.1	0.3	0.4	-0.3	0.4	-0.3
Intermittent access day 15 total locomotion	0.5	0.9	2.7	-0.6	-1.6	-0.5	1.2	-0.4	0.9	0.6	1.0	1.0
Intermittent access total locomotion	0.7	0.9	2.3	0.1	-1.3	-1.4	0.0	-0.8	0.7	-0.8	1.5	-0.5
Intermittent access standard deviation	0.0	0.0	0.2	-0.3	-0.1	0.0	-0.2	-0.2	-0.0	0.4	0.1	0.1
Left kidney weight	0.7	3.2	11.4	-3.0	-0.0	0.5	0.1	-0.9	-1.5	3.4	-1.8	1.2
Right kidney weight	0.7	3.0	11.4	-1.9	-1.0	1.6	1.4	-0.1	-0.4	3.4	-1.6	2.1
Cocaine induced anxiety	0.9	1.2	3.6	-0.8	-0.9	-1.9	-0.2	-1.5	0.0	-1.2	1.2	-0.9
Post-drug Anxiety	1.0	1.0	2.3	0.4	-1.5	-0.7	1.2	-0.1	1.3	-0.8	1.5	0.5
Baseline Anxiety	2.1	2.5	3.9	2.0	-0.8	1.6	1.9	1.9	1.9	0.5	0.4	2.0
Tail length	0.7	2.9	7.6	-2.5	-1.3	-2.5	-0.7	-2.8	-1.2	0.9	-0.1	-1.1
Length with tail	0.8	3.5	10.4	-3.2	-1.6	-2.3	-0.2	-2.9	-1.2	1.6	-0.1	-0.4
Length without tail	0.3	0.9	2.5	-1.2	-1.6	-0.6	0.7	-1.2	0.2	0.9	0.6	0.7
Times rat made contact with spout	1.1	1.3	3.6	0.0	1.2	-1.3	-1.1	-0.2	-0.7	-1.7	0.6	-1.9
Lifetime Intake	1.2	1.4	3.4	0.2	-1.8	-1.5	-0.1	-1.4	0.8	-1.1	1.6	-0.6
Liver weight, left	0.1	0.2	0.7	-0.4	0.1	0.6	-0.1	0.0	-0.4	0.8	-0.6	0.3
Liver weight, right	1.0	1.8	5.8	-1.2	1.0	1.1	0.1	0.8	-0.9	2.4	-1.9	1.1
Locomotor activity	1.5	2.3	5.7	-1.0	0.5	-2.4	-2.1	-1.4	-1.2	-1.0	0.5	-2.2
Locomotor testing distance	0.3	0.6	1.4	-1.1	-0.7	-1.1	-0.5	-1.2	-0.3	0.0	0.3	-0.4
Locomotor testing rearing	0.6	1.3	3.4	-1.1	-1.0	-1.8	-0.7	-1.8	-0.2	-0.7	1.0	-1.0
Locomotion in novel chamber	0.3	0.3	1.4	0.6	0.0	1.2	0.5	0.7	0.4	0.3	-0.3	0.5
Locomotion in novel chamber post-restriction	0.7	1.2	3.4	1.7	1.2	1.4	0.2	1.8	0.7	-0.8	-0.0	0.4
Fecal boli incidents, locomotor time 1	0.3	0.5	1.2	0.4	0.3	-0.7	-1.0	-0.4	-0.4	-0.8	0.5	-1.1
Change in fecal boli incidents, locomotor task	0.3	0.3	1.2	0.0	1.1	-0.3	-0.6	0.3	-0.5	-0.5	-0.3	-0.7
Time >=10cm from walls, locomotor time 1	2.0	2.1	5.3	1.0	-0.2	2.0	1.4	1.8	1.2	1.4	-0.7	2.3
Bouts of movement, locomotor time 1	0.7	0.8	1.5	0.9	-0.3	0.6	1.2	1.2	1.1	0.2	0.6	1.2
Total resting periods, locomotor time 1	0.9	1.0	2.1	0.8	-0.2	0.8	1.4	1.4	1.2	0.3	0.6	1.3
Rest time, locomotor task time 1	0.1	0.1	0.4	-0.5	0.7	-0.3	-0.3	0.1	-0.4	0.4	-0.0	-0.3
Distance moved, locomotor task time 1	0.1	0.2	0.6	-0.3	-0.0	-0.5	-0.3	-0.5	-0.4	0.3	-0.8	-0.2
Vertical activity count, locomotor time 1	0.2	0.4	1.1	1.0	-0.1	-0.5	-0.6	-0.2	0.1	-1.0	-0.0	-0.9
Time >=10cm from walls, locomotor time 2	0.2	0.3	0.8	0.9	0.1	0.6	0.1	0.9	0.3	0.3	0.1	0.4
Bouts of movement, locomotor time 2	0.2	0.3	1.0	-0.1	-0.2	0.7	0.5	0.6	0.6	0.3	0.4	1.0
Total resting periods, locomotor time 2	0.3	0.5	1.4	-0.0	-0.1	0.7	0.8	1.0	0.7	0.4	0.5	1.2
Rest time, locomotor task time 2	0.2	0.2	0.9	-0.4	0.9	-0.0	-0.2	0.4	-0.6	0.5	-0.6	-0.2
Distance moved, locomotor task time 2	0.1	0.1	0.3	0.2	0.0	0.4	0.2	0.0	-0.0	0.3	-0.6	0.3
Vertical activity count, locomotor time 2	0.4	0.6	2.0	1.4	-0.7	0.0	0.3	-0.0	0.8	-1.2	0.7	-0.3
Light reinforcement 1	0.4	0.9	3.7	-1.6	-0.2	-0.1	-0.1	-0.8	-0.6	1.9	-0.8	0.8
Light reinforcement 2	1.1	1.7	5.3	-2.0	0.6	-0.2	-0.7	-0.6	-1.4	2.3	-1.6	0.4
Bone: marrow area	0.2	0.5	1.0	-1.0	0.3	-0.7	-1.0	-1.0	-0.9	0.3	-0.4	-0.7
Bone: maximum diameter	1.2	2.3	9.2	-3.0	-0.9	-2.3	-0.1	-2.0	-0.8	1.0	0.4	0.1
Bone: maximum force	0.9	1.6	4.6	-2.1	0.5	-0.2	-0.2	-0.6	-1.2	2.1	-1.6	0.6
Bone: maximum moment	0.9	1.6	5.0	-2.2	0.2	-0.6	-0.6	-1.3	-1.5	1.8	-1.4	-0.0
Mean time between licks in bursts	0.6	1.5	4.4	-0.3	1.1	-1.5	-1.4	-1.0	-1.2	-1.3	-0.0	-2.1
Mean num. licks in bursts	0.7	1.2	3.2	1.2	1.5	0.3	-0.7	1.4	0.3	-1.8	0.6	-0.8
Cd content in liver	0.2	0.2	1.0	-0.3	0.2	-1.0	-0.3	-0.3	-0.2	0.0	-0.1	-0.4
Co content in liver	0.2	0.3	0.8	-0.1	-0.9	-0.5	0.4	-0.3	0.5	-0.2	0.8	0.2
Cu content in liver	0.7	0.8	1.6	1.3	-0.9	0.4	0.9	0.5	1.3	-1.0	1.0	0.4
Fe content in liver	1.6	1.9	5.9	2.4	0.3	1.7	0.6	1.8	1.4	-1.3	0.9	0.5
K content in liver	2.9	2.8	8.7	1.3	-3.0	0.1	1.7	-0.4	2.2	-0.9	2.2	1.1
Mg content in liver	1.4	1.4	5.1	0.1	-2.3	-0.2	1.4	-0.4	1.3	-0.0	1.5	1.0
Mn content in liver	0.4	0.4	1.3	0.5	-0.8	-0.7	-0.1	-0.4	0.3	-1.1	0.7	-0.7
Na content in liver	3.7	3.9	9.9	1.7	-2.6	-0.8	1.9	0.0	2.6	-2.2	3.1	0.4
Rb content in liver	0.3	0.3	0.8	-0.0	-0.9	-0.4	0.8	-0.0	0.7	0.0	0.6	0.6
Se content in liver	1.2	1.4	5.8	0.1	-2.4	-0.6	0.7	-1.3	0.9	-1.0	1.7	-0.2
Sr content in liver	0.9	0.8	2.8	-1.7	-0.4	-1.5	-0.0	-1.1	-0.6	0.2	0.4	-0.4
Zn content in liver	0.8	0.8	1.9	-1.4	-0.1	-1.0	-0.8	-1.3	-1.2	0.6	-0.5	-0.7
Bone: minimum diameter	0.4	0.7	2.4	-1.5	0.5	-0.2	-0.8	-0.8	-1.2	0.9	-0.7	-0.3
Time in familiar zone, hab. session 1	0.7	0.7	2.0	0.2	1.4	0.7	-0.5	0.7	-0.5	0.7	-1.4	0.0
Time in novel zone, hab. session 1	0.8	0.8	2.1	-0.8	-1.2	-1.0	-0.2	-1.5	-0.3	-0.4	0.9	-0.7
Total zone transitions, hab. session 1	0.2	0.3	1.2	0.4	1.1	-0.1	-0.4	0.8	-0.2	-0.2	-0.3	-0.4
Total locomotion distance, hab. session 1	0.3	0.4	1.6	0.8	0.0	-0.5	-0.3	0.1	0.3	-1.3	0.8	-0.8
Locomotion velocity, hab. session 1	0.2	0.3	0.9	0.8	0.3	-0.1	-0.1	0.5	0.4	-1.0	0.6	-0.2
Time in familiar zone, hab. session 2	1.2	1.3	4.6	1.2	1.2	2.1	-0.0	1.4	0.0	0.4	-1.2	0.6
Time in novel zone, hab. session 2	1.8	1.9	5.8	-2.4	-0.4	-2.3	-0.6	-1.7	-1.0	0.6	0.2	-0.7
Total zone transitions, hab. session 2	0.2	0.2	0.8	-0.5	0.6	-0.9	-0.3	0.2	-0.3	0.2	-0.3	-0.1
Total locomotion distance, hab. session 2	0.4	0.5	1.9	-0.9	0.6	-1.4	-0.8	-0.5	-0.5	-0.1	-0.2	-0.6
Locomotion velocity, hab. session 2	0.3	0.3	2.0	-0.6	0.1	-1.4	-0.4	-0.4	-0.2	-0.3	0.2	-0.4
Novel to familiar place preference ratio	1.2	1.3	4.3	0.7	-1.0	-0.7	1.3	0.7	1.4	-1.2	2.1	0.3
Novelty place preference	1.0	1.0	3.8	0.4	-0.9	-0.9	1.0	0.3	1.1	-1.2	2.0	0.1
Time in novel zone, NPP test	0.7	0.8	3.1	0.1	-0.7	-1.0	0.8	0.2	0.8	-1.0	1.8	-0.0
Total zone transitions, NPP test	0.1	0.2	0.4	0.4	-0.2	0.6	0.5	0.6	0.4	0.1	-0.0	0.6
Total locomotion distance, NPP test	0.3	0.4	0.8	0.8	-0.6	0.3	0.6	0.5	0.9	-0.7	0.7	0.4
Locomotion velocity, NPP test	0.6	0.9	1.7	1.3	-1.0	0.3	0.9	0.6	1.3	-1.0	1.1	0.5
Intraocular pressure	0.4	0.6	2.4	-0.8	1.5	-0.4	-0.2	0.9	-0.5	0.7	-0.9	0.3
Delta distance traveled before/after self-admin	0.7	0.7	1.9	0.5	-0.5	1.2	1.0	0.6	0.9	0.5	0.1	1.4
Delta ambulatory time before/after self-admin	0.4	0.5	1.1	1.1	-0.5	1.1	0.6	0.5	0.8	-0.1	0.2	0.8
Parametrial fat weight	0.6	1.4	3.1	0.5	0.3	-1.4	1.2	1.6	1.4	-1.2	1.7	0.3
Pavlov. Cond. lever latency	0.4	0.5	1.0	0.4	-0.5	-0.6	-0.6	-1.0	0.0	-0.9	0.7	-0.9
Pavlov. Cond. magazine entry latency	0.5	0.6	2.3	-0.0	1.5	0.4	-0.4	1.0	-0.7	0.0	-1.0	-0.5
Pavlov. Cond. change in total contacts	0.4	0.5	1.1	0.2	-0.3	-0.8	1.0	0.9	0.8	-0.5	0.7	0.3
Pavlov. Cond. index score	0.5	0.6	2.4	0.4	1.0	1.0	0.5	1.6	0.0	0.2	-0.7	0.4
Pavlov. Cond. latency score	0.5	0.6	2.1	0.2	1.0	0.9	0.4	1.4	-0.2	0.5	-1.0	0.5
Pavlov. Cond. lever contacts	0.4	0.5	1.6	-0.1	0.7	0.8	0.6	1.3	-0.0	0.8	-0.8	0.8
Pavlov. Cond. magazine entry number	0.5	0.6	2.5	-0.7	-1.3	-0.5	-0.1	-1.6	-0.0	0.6	0.3	0.3
Pavlov. Cond. intertrial magazine entries	0.3	0.4	1.9	-0.1	-1.4	0.1	0.5	-0.7	0.4	0.3	0.5	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	2.3	0.4	1.0	1.0	0.5	1.5	-0.1	0.3	-0.8	0.4
Pavlov. Cond. response bias	0.2	0.2	1.1	0.5	0.3	0.3	0.5	1.1	0.3	-0.4	0.0	0.1
Pavlov. Cond. lever latency	0.6	0.8	3.4	-0.2	-1.9	-0.6	0.7	-1.4	0.6	0.4	0.1	0.4
Pavlov. Cond. magazine entry latency	0.1	0.1	0.5	-0.4	0.0	0.1	0.5	0.4	-0.0	0.7	0.1	0.5
Pavlov. Cond. change in total contacts	0.2	0.3	1.2	-0.1	1.1	0.6	-0.1	1.1	-0.2	0.3	-0.1	0.3
Pavlov. Cond. index score	0.2	0.3	1.3	-0.1	1.1	0.6	-0.2	1.0	-0.4	0.3	-0.1	0.1
Pavlov. Cond. latency score	0.3	0.3	1.3	-0.1	1.2	0.6	-0.2	1.0	-0.4	0.3	-0.2	0.1
Pavlov. Cond. lever contacts	0.6	0.8	2.8	0.6	1.7	0.9	-0.5	1.5	-0.3	-0.6	0.0	-0.3
Pavlov. Cond. magazine entry number	0.3	0.3	1.0	1.0	-0.6	0.1	0.2	0.0	0.8	-0.9	0.4	-0.1
Pavlov. Cond. intertrial magazine entries	0.2	0.3	1.3	0.6	-0.3	-0.1	-0.3	-0.3	0.3	-1.1	0.5	-0.5
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	1.4	-0.1	1.2	0.6	-0.2	1.0	-0.4	0.4	-0.3	0.1
Pavlov. Cond. response bias	0.3	0.4	1.4	0.3	1.2	0.6	-0.2	1.2	-0.2	-0.2	0.1	-0.0
Time in closed arm before self-admin	1.2	1.5	3.4	-1.8	0.7	-0.2	-0.9	-1.2	-1.7	1.2	-1.8	-0.4
Time in closed arm after self-admin	0.7	0.8	2.4	-0.2	0.9	1.5	-0.1	0.1	-1.0	0.6	-1.5	0.1
Time in open arm before self-admin	0.0	0.0	0.1	0.2	0.1	0.1	-0.1	0.2	0.1	0.3	-0.1	0.1
Time in open arm after self-admin	0.2	0.2	0.6	-0.2	-0.3	-0.8	0.4	0.2	0.5	0.3	0.7	0.5
Bone: periosteal estimation	0.6	1.3	5.2	-2.3	-0.3	-1.0	-0.2	-1.3	-1.0	1.5	-0.5	0.2
Bone: periosteal perimeter	0.6	1.0	3.9	-2.0	-1.1	-0.9	0.7	-1.0	-0.1	1.1	0.4	0.8
Bone: post-yield work	0.4	0.6	1.5	-0.0	0.0	-0.9	-1.1	-0.9	-0.5	-0.8	0.3	-1.2
Progressive ratio test 1 active lever presses	1.9	2.4	6.1	1.6	-2.2	-0.9	0.8	-0.5	1.8	-1.8	2.5	-0.2
Progressive ratio test 1 breakpoint	2.0	2.4	6.1	1.6	-2.2	-0.8	0.9	-0.4	1.8	-1.8	2.5	-0.1
Progressive ratio test 1 inactive lever presses	1.2	1.8	5.0	0.4	-1.8	-1.7	0.7	-0.9	1.3	-1.3	2.2	-0.2
Progressive ratio test 2 active lever presses	0.5	0.6	1.7	0.3	-1.3	-0.9	0.6	-0.6	0.9	-0.6	1.1	0.2
Progressive ratio test 2 breakpoint	0.4	0.5	1.4	0.2	-1.2	-0.8	0.5	-0.5	0.9	-0.5	1.0	0.3
Progressive ratio test 2 inactive lever presses	0.5	0.8	1.3	-1.2	-1.0	-0.9	0.9	-0.5	0.7	0.6	0.7	1.1
Incentive Sensitization - Responses	0.2	0.3	0.8	-0.7	-0.1	-0.2	0.6	-0.0	0.2	0.8	-0.4	0.9
Incentive Sensitization - Breakpoint	0.3	0.4	1.0	-0.9	0.1	-0.1	0.5	-0.1	0.0	1.0	-0.6	0.9
Sum of active levers in priming session hrs 5-6	1.5	1.4	2.7	1.1	-1.7	0.8	1.6	0.5	1.5	-0.5	1.3	0.9
Progressive ratio	0.0	0.0	0.1	-0.2	-0.3	-0.3	0.2	-0.3	-0.1	-0.1	-0.1	-0.2
Food seeking constrained by brief footshock	0.7	0.9	3.1	-0.3	-1.8	-1.0	1.2	-0.5	0.8	0.3	1.0	0.4
Seeking ratio, punishment vs. effort	0.1	0.1	0.3	-0.6	-0.5	-0.4	0.1	-0.4	0.1	0.2	0.4	0.2
Retroperitoneal fat weight	0.3	1.4	4.2	-0.2	0.6	0.1	1.6	2.0	1.2	0.8	0.2	1.9
Reaction time number correct	2.0	3.7	7.6	-2.0	1.7	-1.7	-2.8	-1.9	-2.5	-0.1	-1.0	-2.3
Reaction time mean minus median	0.1	0.3	1.3	0.6	-0.4	-0.3	-0.1	-0.5	0.3	-1.1	0.8	-0.5
Reaction time mean minus median AUC	0.0	0.1	0.3	-0.2	-0.5	0.1	0.4	-0.2	0.3	0.1	0.5	0.5
Reaction time num false alarms	1.4	1.9	4.9	0.4	-1.2	1.0	2.2	1.3	1.6	1.0	0.5	2.1
Reaction time num false alarms AUC	1.3	2.0	5.3	0.1	-1.0	1.3	2.1	1.3	1.3	1.6	-0.0	2.3
Reaction time trials correct on left	2.0	3.7	7.6	-2.0	1.7	-1.7	-2.8	-1.9	-2.5	-0.1	-1.0	-2.3
Reaction time trials on left	2.0	3.7	7.8	-2.0	1.7	-1.7	-2.8	-1.9	-2.5	-0.1	-1.0	-2.3
Reaction time mean	0.3	0.5	1.6	1.3	-0.7	0.8	0.5	0.2	0.8	-0.7	0.5	0.3
Reaction time mean AUC	0.3	0.4	1.3	1.1	-0.6	0.9	0.4	0.1	0.7	-0.6	0.4	0.4
Median of all reaction times	0.4	0.6	2.0	1.4	-0.6	1.1	0.6	0.4	0.9	-0.5	0.3	0.6
Reaction time omissions	0.1	0.1	0.5	0.5	0.4	0.7	-0.2	0.4	0.2	-0.4	0.1	0.0
Reaction time false alarm rate	3.3	4.5	10.7	0.9	-1.8	2.0	3.3	2.0	2.4	1.5	0.5	3.2
Reaction time premature initiation rate	1.4	2.0	4.3	0.2	1.8	2.1	-0.0	1.7	-0.5	1.6	-1.9	0.9
Reaction time premature initiations	1.1	2.0	5.4	-0.8	2.3	0.7	-1.5	0.5	-1.7	1.2	-2.1	-0.4
Std. dev. reaction times	0.1	0.1	0.4	0.6	-0.2	0.3	0.2	0.0	0.5	-0.4	0.4	0.3
Reaction time trials completed	2.0	3.7	7.8	-2.0	1.7	-1.7	-2.8	-1.9	-2.5	-0.1	-1.0	-2.3
Reaction time trials AUC	2.0	3.8	7.8	-2.0	1.5	-1.9	-2.8	-2.1	-2.5	-0.3	-0.9	-2.4
Run reversals in cocaine runway, females	2.9	2.9	5.4	2.3	-0.4	2.3	1.9	2.2	1.9	0.1	0.0	1.9
Run reversals in cocaine runway, males	0.1	0.1	0.3	-0.5	0.2	-0.3	0.1	-0.2	-0.5	0.3	-0.3	-0.3
Latency to leave start box in cocaine runway	0.6	0.6	1.4	0.8	-0.7	0.6	1.2	1.1	1.0	0.1	0.8	0.4
Latency to leave start box in cocaine runway, F	0.8	0.9	2.4	-0.7	-0.5	0.8	1.6	0.9	0.4	1.4	-0.2	1.2
Latency to leave start box in cocaine runway, M	1.3	1.2	2.9	1.7	-0.6	-0.3	-0.1	0.4	1.1	-1.6	1.7	-0.8
Std. dev. time between licks in bursts	0.2	0.3	0.9	0.3	1.0	-0.1	-0.2	0.3	-0.6	-0.4	-0.5	-0.9
Total sessions with >9 infusions	0.1	0.1	0.2	0.3	-0.1	0.2	-0.4	-0.0	0.2	-0.3	0.4	-0.4
Short access day 1 total inactive lever presses	1.0	1.3	5.0	-1.4	-0.8	-2.2	-0.4	-1.5	-0.2	-0.2	0.8	-0.9
Short access day 10 total inactive lever presses	0.5	1.2	3.3	-1.8	0.6	-0.9	-1.2	-1.4	-1.3	0.1	-0.3	-1.0
Short access day 1 total infusions	0.0	0.1	0.2	0.2	-0.4	0.3	-0.2	-0.3	0.3	-0.2	0.1	0.0
Short access day 10 total infusions	0.2	0.2	0.8	0.9	-0.2	-0.1	-0.4	0.1	0.4	-0.4	0.5	-0.3
Short access total infusions	0.3	0.4	0.6	0.2	-0.8	-0.7	-0.6	-0.8	0.3	-0.7	0.7	-0.6
Short access day 1 locomotion	0.5	0.6	1.4	-0.4	0.8	-0.1	-1.2	-0.5	-1.1	0.4	-0.8	-0.9
Short access day 10 total locomotion	0.6	1.1	3.6	1.0	1.1	-0.1	-1.6	0.1	-0.7	-1.1	0.0	-1.9
Short access total locomotion	1.0	1.2	3.5	0.1	1.5	-0.2	-1.9	-0.1	-1.3	-0.3	-0.6	-1.8
One hour access (0.3 mA shock)	1.0	1.1	2.4	0.8	-1.4	-1.2	-0.1	-0.9	0.9	-1.4	1.5	-0.6
Compulsive drug intake	1.1	1.4	4.2	2.1	0.5	2.0	0.6	1.7	0.6	-0.4	-0.2	0.3
One hour access (shock baseline)	1.4	2.2	4.4	0.0	-2.1	-2.0	-0.1	-1.8	0.9	-1.5	2.1	-0.7
Social response proportion	1.1	1.3	3.1	-0.8	0.9	-1.8	-1.3	-1.2	-1.2	-0.6	-0.3	-1.3
Social responses	1.2	1.5	3.6	-1.1	1.0	-1.9	-1.4	-1.4	-1.2	-0.7	-0.3	-1.4
Social time	0.3	0.5	0.8	0.3	0.9	-0.1	-0.9	-0.5	-0.7	-0.8	-0.7	-0.8
Soleus weight	1.4	4.2	12.6	-3.6	-0.5	-2.1	-1.3	-2.9	-2.3	1.9	-1.0	-1.0
Bone: stiffness	0.4	0.6	1.8	0.1	0.1	0.9	0.9	1.1	0.5	0.8	-0.4	1.4
Tibialis anterior weight	0.4	1.4	3.2	-1.7	-1.5	-1.8	0.4	-1.5	-0.1	0.8	1.0	0.1
Time to tail flick, vehicle, before self-admin	0.7	0.8	2.1	-0.1	0.1	1.0	1.0	0.8	0.4	1.2	-0.9	1.4
Time to tail flick, vehicle, after self-admin	1.1	1.5	3.3	1.8	-0.2	1.3	1.1	1.6	1.6	-0.9	1.0	0.6
Time to tail flick, test, before self-admin	0.4	0.4	0.7	-0.8	0.5	-0.0	-0.8	-0.5	-0.8	-0.3	-0.4	-0.7
Time to tail flick, test, after self-admin	2.3	2.4	6.1	-2.5	-0.1	-2.2	-1.1	-2.1	-1.5	-0.1	-0.1	-1.5
Delta time to tail flick, vehicle, before/after SA	1.2	1.2	3.2	1.8	-0.2	0.3	0.1	1.0	1.1	-1.6	1.5	-0.6
Delta time to tail flick, test, before/after SA	0.6	0.6	2.2	-1.0	-0.3	-1.5	-0.5	-1.0	-0.5	0.1	0.3	-0.7
Tibia length	0.5	1.3	4.7	-0.7	0.0	1.3	0.6	0.3	-0.4	2.2	-1.8	1.1
Ambulatory time before self-admin	0.7	1.1	2.9	1.7	-1.2	-0.4	0.4	0.2	1.2	-1.3	1.3	-0.5
Ambulatory time after self-admin	1.4	1.6	5.5	2.3	-1.3	0.2	0.6	0.4	1.6	-1.5	1.4	-0.1
Bone: tissue strength	2.8	2.8	5.3	-2.1	1.2	-0.9	-2.2	-1.7	-2.3	0.8	-1.8	-1.3
Total heroin consumption	0.1	0.1	0.3	-0.3	0.0	-0.2	-0.5	-0.5	-0.5	-0.2	-0.2	-0.4
Bone: trabecular number	0.1	0.2	0.7	0.8	-0.7	0.3	-0.1	-0.4	0.2	-0.5	0.2	-0.4
Bone: trabecular spacing	0.4	0.6	2.4	-1.6	0.5	-1.0	-0.4	-0.5	-0.6	0.7	-0.4	-0.1
Bone: trabecular thickness	0.2	0.3	1.4	1.2	-0.3	0.9	-0.3	0.0	-0.0	-0.2	-0.3	-0.2
Bone: trabecular tissue density	0.2	0.4	0.9	0.9	0.2	0.6	0.4	0.9	0.6	-0.6	0.2	0.3
Water consumed over 24 hours	2.0	2.7	6.3	-0.9	1.6	-2.0	-2.0	-1.3	-1.9	-1.1	-0.5	-2.5
Number of responses in last shaping day	1.3	1.4	2.5	1.5	-0.1	1.2	1.3	1.6	1.6	-0.6	0.7	1.3