Hub : Genes

Orc1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Orc1 0.11 0.07 2.6e-07 0.07 0.07 0.06 0.06 7.9e-08 8.7e-08 9.8e-08 2.8e-07
2 Adipose isoform ratio XM_063287715.1 0.04 0.03 7.7e-04 0.02 0.02 0.02 0.02 1.3e-03 2.6e-03 2.4e-03 5.4e-03
3 Adipose isoform ratio XM_039109968.2 0.06 0.04 5.8e-05 0.03 0.03 0.02 0.03 1.9e-04 1.5e-04 1.3e-03 4.0e-04
4 pVTA alternative polyA XM_039109968.2 0.03 0.03 9.1e-03 0.02 0.02 0.02 0.02 7.4e-03 4.3e-03 8.9e-03 8.7e-03
5 RMTg alternative TSS NM_177931.2 0.15 0.13 9.5e-03 0.05 0.05 0.02 0.04 2.3e-02 2.1e-02 9.3e-02 2.5e-02
6 pVTA alternative polyA XM_006238515.5 0.27 0.24 6.8e-03 0.02 0.01 0.03 0.02 4.5e-03 5.5e-02 3.9e-03 5.5e-03
7 RMTg alternative TSS NM_177931.2 0.17 0.15 5.5e-03 0.06 0.05 0.06 0.06 1.3e-02 1.8e-02 1.1e-02 1.4e-02
8 pVTA alternative polyA NM_177931.2 0.29 0.24 4.1e-03 0.03 0.01 0.03 0.03 3.2e-03 3.9e-02 2.6e-03 4.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.40.71.20.50.5-0.61.11.1-1.01.00.7
Area under the delay curve0.20.30.8-0.9-0.90.80.0-0.0-0.10.10.1
BMI with tail1.03.66.40.10.5-0.1-2.3-2.22.5-2.4-2.5
BMI without tail0.51.52.70.20.20.2-1.5-1.51.6-1.5-1.5
Body weight0.62.44.10.30.4-0.0-1.9-1.92.0-2.0-2.0
Weight adjusted by age0.30.51.11.01.0-0.8-0.5-0.50.6-0.6-0.5
Bone surface0.10.20.40.00.00.00.60.6-0.70.70.5
Bone volume0.00.00.10.20.2-0.10.20.2-0.20.20.1
Breakpoint value in progressive ratio session0.00.00.10.30.3-0.20.10.1-0.10.10.0
Number of licking bursts0.40.61.51.21.2-0.8-0.3-0.30.5-0.5-0.8
Context. condit. distance diff. score0.60.71.11.10.9-0.80.80.9-0.60.70.6
Locomotion velocity, session 12.83.04.51.51.4-1.62.12.1-1.81.81.4
Locomotion distance, session 10.20.30.80.70.9-0.70.30.3-0.10.2-0.1
Locomotion velocity, session 22.73.14.41.61.7-1.72.02.1-1.81.71.3
Locomotion distance, session 20.60.81.1-0.8-0.81.1-1.0-1.10.8-0.8-0.7
Locomotion velocity, session 30.60.71.20.60.4-0.41.11.1-1.01.10.7
Locomotion distance, session 30.20.30.8-0.6-0.80.9-0.3-0.40.1-0.10.0
Stereotopy head waving bouts, day 30.30.30.91.00.9-0.80.20.20.0-0.0-0.4
Stereotopy head waving duration, day 31.01.12.71.61.6-1.60.70.8-0.30.4-0.3
Locomotion velocity, session 70.40.51.1-0.5-1.01.00.20.1-0.50.51.0
Locomotion distance, session 71.31.64.4-1.8-1.92.1-0.2-0.4-0.40.31.0
Stereotopy head waving bouts, day 71.41.62.51.31.0-1.11.51.6-1.31.40.9
Stereotopy head waving duration, day 71.51.82.81.31.1-1.31.61.7-1.31.40.9
Locomotion velocity, session 81.51.72.70.50.6-0.71.61.6-1.61.51.7
Locomotion distance, session 80.00.00.10.20.10.00.20.2-0.20.30.4
Degree of sensitization distance0.20.20.5-0.7-0.50.7-0.3-0.40.1-0.20.2
Degree of sensitization stereotypy0.70.81.30.80.5-0.61.11.1-0.91.10.7
Conditioned locomotion0.70.82.01.41.4-1.2-0.1-0.00.4-0.4-0.5
Cocaine response after cond. corrected1.92.33.3-1.3-1.31.5-1.8-1.81.5-1.5-1.3
Cocaine response after cond. not corrected2.12.53.9-0.9-0.91.2-1.9-2.01.8-1.8-1.6
Cocaine response before conditioning0.20.20.40.60.6-0.6-0.1-0.10.3-0.3-0.3
Saline control response1.01.33.4-1.8-1.81.8-0.3-0.5-0.10.10.7
Bone: connectivity density0.71.12.0-0.1-0.0-0.11.31.3-1.41.41.1
Bone: cortical apparent density1.62.23.41.21.0-1.21.81.8-1.61.61.4
Bone: cortical area0.91.32.3-0.6-0.60.8-1.5-1.51.4-1.4-1.0
Bone: cortical porosity1.61.74.52.02.1-2.00.40.60.0-0.0-0.4
Bone: cortical porosity1.51.63.71.91.9-1.90.80.9-0.40.40.1
Bone: cortical thickness1.72.94.9-0.2-0.10.4-2.2-2.22.2-2.2-1.9
Bone: cortical thickness1.41.72.90.70.7-0.3-1.5-1.41.7-1.7-1.5
Bone: cortical tissue density1.82.53.81.31.1-1.31.91.9-1.71.71.4
Condit. Reinf. active minus inactive responses0.40.50.80.10.10.2-0.8-0.80.8-0.9-0.9
Condit. Reinf. active-inactive response ratio0.50.60.9-0.2-0.10.3-1.0-1.00.9-0.9-0.9
Condit. Reinf. active responses0.81.01.70.10.10.3-1.3-1.31.2-1.3-1.3
Condit. Reinf. inactive responses0.10.10.2-0.2-0.30.5-0.4-0.40.2-0.3-0.1
Incentive salience index mean1.31.62.90.20.30.2-1.6-1.51.6-1.6-1.7
Condit. Reinf. lever presses1.31.83.20.30.30.2-1.6-1.61.7-1.7-1.8
Condit. Reinf. active minus inactive responses0.81.02.2-1.4-1.41.5-0.7-0.80.4-0.40.3
Condit. Reinf. active-inactive response ratio0.40.51.2-1.1-1.11.1-0.3-0.30.0-0.00.4
Condit. Reinf. active responses0.30.40.7-0.8-0.80.8-0.6-0.70.5-0.5-0.1
Condit. Reinf. inactive responses0.20.30.60.30.3-0.2-0.6-0.60.7-0.7-0.8
Condit. Reinf. lever presses0.71.02.2-1.5-1.51.50.20.1-0.60.60.7
Condit. Reinf. lever reinforcers received0.40.51.1-1.0-1.01.0-0.6-0.60.3-0.30.1
Conditioned reinforcement - actives2.03.54.4-2.0-2.02.1-2.0-2.11.7-1.7-0.9
Conditioned reinforcement - inactives0.00.10.10.00.00.1-0.3-0.30.3-0.3-0.2
Conditioned locomotion0.81.01.4-1.0-1.01.0-1.2-1.21.0-1.0-0.6
Patch foraging indifference point 0 sec0.20.50.8-0.4-0.40.5-0.9-0.90.8-0.8-0.7
Patch foraging indifference point AUC0.10.20.3-0.0-0.0-0.10.60.6-0.60.60.4
Delay disc. indifference point, 0s delay0.60.61.6-1.2-1.21.00.40.4-0.50.60.5
Delay disc. indifference point, 16s delay0.90.91.4-0.5-0.50.6-1.2-1.21.2-1.1-1.1
Delay disc. indifference point, 2s delay0.10.10.1-0.4-0.40.30.20.2-0.20.30.3
Delay disc. indifference point, 24s delay0.20.20.4-0.4-0.40.30.40.4-0.40.40.6
Delay disc. indifference point, 4s delay0.10.10.2-0.4-0.40.4-0.2-0.20.1-0.10.0
Delay disc. indifference point, 8s delay0.20.20.5-0.7-0.70.6-0.1-0.10.00.00.0
Indifference point function ln k0.20.40.7-0.0-0.00.2-0.8-0.80.8-0.8-0.8
Indifference point function log k0.20.40.7-0.0-0.00.2-0.8-0.80.8-0.8-0.8
Patch foraging total patch changes 0 sec0.20.40.6-0.2-0.20.3-0.8-0.80.7-0.7-0.7
Patch foraging total patch changes 12 sec0.70.91.40.10.1-0.31.21.2-1.21.21.1
Patch foraging total patch changes 18 sec0.20.30.8-0.1-0.10.2-0.6-0.60.6-0.6-0.9
Patch foraging total patch changes 24 sec0.50.91.5-0.0-0.00.1-1.2-1.21.2-1.2-1.2
Patch foraging total patch changes 6 sec0.30.41.0-1.0-1.01.0-0.5-0.50.2-0.3-0.2
Patch foraging time to switch 0 sec0.61.32.20.60.6-0.91.41.5-1.31.31.1
Patch foraging water rate 0 sec1.02.13.40.00.00.3-1.8-1.81.8-1.8-1.8
Patch foraging water rate 12 sec1.42.94.5-0.7-0.70.9-2.1-2.12.0-2.0-2.0
Patch foraging water rate 18 sec0.10.20.40.70.7-0.60.10.1-0.0-0.1-0.0
Patch foraging water rate 24 sec0.20.20.70.80.8-0.7-0.1-0.00.1-0.3-0.3
Patch foraging water rate 6 sec0.91.22.3-0.1-0.10.3-1.4-1.41.4-1.4-1.5
Seeking ratio, delayed vs. immediate footshock1.92.33.7-0.7-0.70.9-1.9-1.91.8-1.8-1.6
Distance traveled before self-admin0.20.30.50.70.7-0.5-0.4-0.40.4-0.5-0.5
Distance traveled after self-admin0.60.81.40.40.4-0.1-1.1-1.11.1-1.2-1.0
Extensor digitorum longus weight0.93.55.91.11.1-0.6-2.1-2.02.4-2.3-2.4
Bone: elastic displacement0.50.61.61.31.1-1.1-0.00.10.3-0.3-0.7
Bone: elastic work0.10.20.20.50.3-0.3-0.3-0.30.4-0.4-0.5
Bone: endosteal estimation0.00.10.2-0.0-0.30.20.30.3-0.40.40.2
Bone: endosteal perimeter0.30.61.3-1.0-1.11.00.50.4-0.80.70.7
Epididymis fat weight0.10.41.0-0.9-1.00.70.40.3-0.50.60.6
Delta time in closed arm before/after self-admin0.00.00.1-0.3-0.30.3-0.0-0.10.0-0.00.0
Delta time in open arm before/after self-admin0.10.10.2-0.3-0.30.3-0.4-0.40.3-0.4-0.5
Diff in mean of infusions in LGA sessions0.40.51.4-1.2-1.21.1-0.2-0.30.0-0.10.3
Delay discount exponential model param0.30.30.80.90.9-0.80.00.00.1-0.1-0.2
Extinction: sum of active levers before priming0.91.02.71.61.6-1.4-0.2-0.10.4-0.4-0.6
Active lever presses in extinction session 61.81.72.4-1.2-1.21.3-1.5-1.61.2-1.4-1.0
Bone: final force0.10.10.2-0.3-0.50.50.10.0-0.20.20.3
Bone: final moment0.10.10.4-0.4-0.60.6-0.1-0.2-0.00.00.2
Food consumed during 24 hour testing period1.41.95.1-2.0-2.02.2-0.8-1.00.3-0.30.2
Glucose0.30.40.8-0.8-0.90.9-0.5-0.60.3-0.3-0.1
Heart weight1.21.83.00.81.0-0.9-1.5-1.41.6-1.7-1.7
Delay discount hyperbolic model param0.20.20.60.80.8-0.6-0.1-0.10.1-0.2-0.2
Intermittent access intake day 1-15 change0.40.81.1-0.9-0.90.9-1.0-1.00.9-0.9-0.2
Intermittent access intake escalation0.30.61.0-0.5-0.50.6-1.0-1.00.9-0.9-0.3
Intermittent access intake escalation 20.10.20.2-0.3-0.30.4-0.5-0.50.5-0.40.2
Intermitt. access day 1 inactive lever presses0.41.52.6-0.6-0.60.8-1.6-1.61.5-1.4-1.1
Intermitt. access day 15 inactive lever presses0.30.71.10.60.6-0.3-0.9-0.91.0-1.0-1.0
Intermitt. access escalation Index0.20.30.90.90.9-0.80.20.3-0.10.1-0.2
Intermittent access day 1 total infusions0.20.30.80.90.9-0.80.20.3-0.10.10.3
Intermittent access day 15 total infusions0.20.30.50.50.5-0.3-0.6-0.60.7-0.7-0.2
Intermittent access terminal intake (last 3 days)0.10.10.10.40.4-0.3-0.2-0.20.3-0.20.3
Intermittent access total infusions0.20.20.60.70.7-0.60.00.00.1-0.10.3
Intermittent access day 1 locomotion0.10.10.30.60.6-0.50.10.1-0.0-0.00.1
Intermittent access day 15 total locomotion0.20.40.7-0.8-0.80.8-0.6-0.60.4-0.40.0
Intermittent access total locomotion0.10.20.40.70.7-0.6-0.1-0.10.2-0.20.1
Intermittent access standard deviation1.02.23.7-0.5-0.50.8-1.9-1.91.9-1.8-1.5
Left kidney weight3.616.928.3-0.3-0.51.5-5.3-5.35.2-5.2-4.7
Right kidney weight2.210.016.90.20.00.8-4.0-4.04.1-4.0-3.8
Cocaine induced anxiety0.91.32.71.61.6-1.1-0.8-0.80.8-0.8-1.0
Post-drug Anxiety2.02.24.92.22.2-1.5-0.9-0.91.0-1.0-1.2
Baseline Anxiety0.10.10.2-0.0-0.00.1-0.4-0.40.3-0.4-0.2
Tail length0.00.10.60.70.4-0.20.10.1-0.10.00.1
Length with tail0.10.50.9-0.0-0.20.5-0.9-0.90.7-0.9-0.6
Length without tail1.13.75.8-1.3-1.21.5-2.4-2.42.1-2.2-1.7
Times rat made contact with spout0.70.82.4-1.0-1.01.5-0.8-0.90.5-0.5-0.5
Lifetime Intake0.00.00.20.10.1-0.10.00.0-0.00.00.4
Liver weight, left0.20.30.4-0.6-0.70.70.30.2-0.50.50.6
Liver weight, right0.20.40.7-0.9-0.60.60.40.3-0.60.60.7
Locomotor activity0.71.02.8-1.6-1.61.7-0.4-0.5-0.1-0.00.4
Locomotor testing distance0.91.63.8-1.9-1.92.0-0.9-1.00.3-0.40.0
Locomotor testing rearing1.12.35.5-2.4-2.42.4-0.7-0.80.2-0.20.4
Locomotion in novel chamber3.13.95.2-1.7-1.71.8-2.2-2.32.0-2.0-2.0
Locomotion in novel chamber post-restriction0.71.12.71.61.6-1.3-0.4-0.30.6-0.6-0.9
Fecal boli incidents, locomotor time 10.40.61.5-1.2-1.21.1-0.2-0.30.1-0.10.2
Change in fecal boli incidents, locomotor task0.30.20.4-0.2-0.20.10.60.6-0.60.60.6
Time >=10cm from walls, locomotor time 11.61.72.61.61.6-1.61.31.3-1.01.00.6
Bouts of movement, locomotor time 10.50.61.0-0.5-0.50.30.90.9-1.00.90.7
Total resting periods, locomotor time 10.30.30.7-0.2-0.20.00.80.7-0.90.70.5
Rest time, locomotor task time 10.20.30.7-0.8-0.80.70.20.2-0.30.30.4
Distance moved, locomotor task time 10.60.92.31.51.5-1.40.40.5-0.40.30.3
Vertical activity count, locomotor time 10.10.20.40.20.2-0.0-0.7-0.60.5-0.6-0.3
Time >=10cm from walls, locomotor time 20.20.30.80.90.9-0.80.10.10.0-0.2-0.1
Bouts of movement, locomotor time 20.50.81.41.21.2-1.20.90.9-0.70.60.3
Total resting periods, locomotor time 20.40.71.01.01.0-1.00.80.9-0.70.60.2
Rest time, locomotor task time 20.20.30.6-0.8-0.80.60.40.3-0.40.40.3
Distance moved, locomotor task time 20.60.70.90.80.8-0.5-0.9-0.90.9-0.9-0.7
Vertical activity count, locomotor time 20.91.32.5-0.4-0.40.6-1.6-1.61.3-1.4-0.9
Light reinforcement 10.20.40.60.80.8-0.7-0.4-0.30.5-0.5-0.6
Light reinforcement 20.91.43.00.50.5-0.2-1.3-1.31.5-1.4-1.7
Bone: marrow area0.00.10.1-0.0-0.30.20.20.2-0.30.30.1
Bone: maximum diameter0.10.20.30.30.2-0.1-0.4-0.40.5-0.5-0.6
Bone: maximum force0.00.10.2-0.4-0.50.5-0.1-0.1-0.10.00.2
Bone: maximum moment0.10.10.3-0.4-0.60.6-0.2-0.30.1-0.10.0
Mean time between licks in bursts0.92.14.2-1.2-1.20.81.31.2-1.61.62.1
Mean num. licks in bursts0.71.12.4-1.5-1.51.5-0.7-0.80.4-0.4-0.1
Cd content in liver0.50.51.1-0.1-0.10.00.80.8-0.90.91.0
Co content in liver0.10.10.2-0.5-0.50.50.10.0-0.20.20.3
Cu content in liver1.61.94.4-2.1-2.11.90.20.1-0.70.71.1
Fe content in liver0.60.71.70.60.6-0.6-0.7-0.70.9-0.9-1.3
K content in liver1.71.73.7-1.9-1.91.90.30.1-0.70.71.1
Mg content in liver2.32.45.6-2.2-2.22.4-1.1-1.30.6-0.6-0.1
Mn content in liver0.20.20.40.30.3-0.30.60.6-0.50.50.5
Na content in liver0.40.40.7-0.5-0.50.40.70.6-0.80.80.8
Rb content in liver0.40.41.1-1.0-1.01.0-0.0-0.1-0.20.20.4
Se content in liver0.40.51.0-1.0-1.00.90.20.1-0.40.40.8
Sr content in liver0.00.00.00.20.2-0.20.00.00.0-0.0-0.1
Zn content in liver1.41.62.7-1.7-1.71.50.70.5-1.11.11.5
Bone: minimum diameter0.91.63.3-1.7-1.81.8-1.0-1.10.6-0.7-0.3
Time in familiar zone, hab. session 10.30.30.50.10.2-0.50.70.7-0.70.60.6
Time in novel zone, hab. session 10.10.10.4-0.4-0.50.60.10.1-0.20.30.2
Total zone transitions, hab. session 10.40.51.61.01.3-1.10.30.4-0.10.1-0.3
Total locomotion distance, hab. session 10.71.02.21.21.5-1.3-0.4-0.30.7-0.7-1.1
Locomotion velocity, hab. session 10.50.71.81.01.3-1.1-0.2-0.10.5-0.5-0.9
Time in familiar zone, hab. session 21.31.33.0-1.7-1.61.30.50.3-0.80.81.3
Time in novel zone, hab. session 20.40.40.90.90.9-0.9-0.1-0.00.4-0.3-0.8
Total zone transitions, hab. session 20.10.10.5-0.2-0.60.7-0.2-0.2-0.0-0.00.1
Total locomotion distance, hab. session 20.20.30.50.3-0.10.3-0.7-0.70.6-0.7-0.6
Locomotion velocity, hab. session 20.30.40.60.40.10.2-0.8-0.80.7-0.8-0.8
Novel to familiar place preference ratio1.71.83.0-1.7-1.61.5-1.3-1.41.1-1.0-0.8
Novelty place preference1.01.12.1-1.5-1.31.2-1.0-1.00.8-0.7-0.6
Time in novel zone, NPP test0.90.92.1-1.4-1.31.1-0.8-0.90.7-0.6-0.5
Total zone transitions, NPP test0.71.01.61.10.8-0.4-1.0-1.01.1-1.3-1.3
Total locomotion distance, NPP test0.81.22.01.00.7-0.3-1.1-1.11.2-1.3-1.4
Locomotion velocity, NPP test1.21.72.81.00.7-0.2-1.5-1.41.5-1.6-1.7
Intraocular pressure0.30.41.1-1.1-0.60.7-0.6-0.70.5-0.5-0.5
Delta distance traveled before/after self-admin1.01.01.6-0.5-0.50.7-1.3-1.31.2-1.2-1.0
Delta ambulatory time before/after self-admin0.60.81.2-0.5-0.50.7-1.1-1.11.0-1.0-0.9
Parametrial fat weight0.00.10.20.30.4-0.40.20.2-0.20.10.1
Pavlov. Cond. lever latency1.51.93.9-0.9-0.90.41.51.4-1.71.62.0
Pavlov. Cond. magazine entry latency0.10.20.40.0-0.00.00.50.5-0.60.60.3
Pavlov. Cond. change in total contacts0.10.10.30.60.5-0.2-0.1-0.10.2-0.2-0.3
Pavlov. Cond. index score0.30.40.90.50.5-0.1-0.6-0.60.7-0.7-1.0
Pavlov. Cond. latency score0.40.51.20.60.5-0.1-0.7-0.70.8-0.8-1.1
Pavlov. Cond. lever contacts1.21.43.00.90.8-0.4-1.2-1.11.4-1.4-1.7
Pavlov. Cond. magazine entry number0.10.20.3-0.2-0.20.2-0.6-0.60.5-0.6-0.2
Pavlov. Cond. intertrial magazine entries1.21.43.1-1.8-1.41.4-1.1-1.20.8-0.8-0.4
Pavlov. Cond. lever-magazine prob. diff.0.40.51.20.30.3-0.0-0.8-0.80.9-0.8-1.1
Pavlov. Cond. response bias0.20.20.50.60.6-0.4-0.2-0.20.4-0.3-0.7
Pavlov. Cond. lever latency1.52.05.12.32.3-2.30.30.50.2-0.2-0.6
Pavlov. Cond. magazine entry latency2.63.16.2-2.5-2.52.30.70.5-1.31.31.6
Pavlov. Cond. change in total contacts1.52.46.1-2.5-2.52.4-0.1-0.3-0.50.51.0
Pavlov. Cond. index score2.63.48.2-2.9-2.92.80.20.0-1.01.01.3
Pavlov. Cond. latency score2.43.27.7-2.8-2.82.70.20.0-0.90.91.2
Pavlov. Cond. lever contacts1.11.64.0-2.0-2.02.0-0.2-0.4-0.30.30.5
Pavlov. Cond. magazine entry number3.03.75.92.42.4-2.2-1.2-1.01.8-1.8-2.1
Pavlov. Cond. intertrial magazine entries0.71.12.91.71.7-1.60.30.40.1-0.1-0.2
Pavlov. Cond. lever-magazine prob. diff.2.93.99.3-3.0-3.02.90.30.0-1.01.01.4
Pavlov. Cond. response bias1.72.35.4-2.3-2.32.20.30.1-0.90.91.2
Time in closed arm before self-admin0.40.50.60.70.7-0.70.80.8-0.60.70.6
Time in closed arm after self-admin0.30.30.50.70.7-0.70.50.5-0.40.40.5
Time in open arm before self-admin0.50.61.6-1.3-1.31.1-0.2-0.2-0.0-0.10.0
Time in open arm after self-admin0.91.01.2-0.9-0.91.0-1.1-1.10.9-0.9-1.1
Bone: periosteal estimation0.20.40.7-0.1-0.30.4-0.8-0.80.8-0.8-0.8
Bone: periosteal perimeter0.10.20.5-0.6-0.70.7-0.4-0.40.2-0.2-0.2
Bone: post-yield work0.00.00.1-0.1-0.20.20.20.2-0.30.20.1
Progressive ratio test 1 active lever presses0.50.61.00.40.4-0.1-0.9-0.91.0-1.0-0.8
Progressive ratio test 1 breakpoint0.50.61.00.50.5-0.2-1.0-0.91.0-1.0-0.9
Progressive ratio test 1 inactive lever presses0.30.40.70.50.5-0.3-0.7-0.70.8-0.7-0.7
Progressive ratio test 2 active lever presses0.30.30.70.40.4-0.2-0.7-0.70.8-0.8-0.3
Progressive ratio test 2 breakpoint0.40.40.70.70.7-0.4-0.7-0.70.8-0.8-0.4
Progressive ratio test 2 inactive lever presses0.00.00.1-0.1-0.10.1-0.3-0.30.3-0.30.2
Incentive Sensitization - Responses0.00.00.10.10.1-0.10.00.00.0-0.10.3
Incentive Sensitization - Breakpoint0.00.00.10.10.1-0.0-0.0-0.10.1-0.10.2
Sum of active levers in priming session hrs 5-60.50.51.11.11.1-0.9-0.3-0.30.4-0.5-0.7
Progressive ratio0.20.30.4-0.4-0.40.4-0.7-0.70.6-0.6-0.5
Food seeking constrained by brief footshock2.12.54.10.50.5-0.82.02.0-1.91.91.8
Seeking ratio, punishment vs. effort2.02.94.90.70.7-1.02.22.2-2.02.11.8
Retroperitoneal fat weight0.00.20.3-0.2-0.0-0.20.60.6-0.60.50.5
Reaction time number correct0.30.61.41.21.2-1.20.20.30.0-0.1-0.0
Reaction time mean minus median1.02.46.4-2.5-2.52.30.0-0.1-0.40.50.7
Reaction time mean minus median AUC0.61.64.0-2.0-2.01.90.10.0-0.50.50.7
Reaction time num false alarms1.31.83.0-1.6-1.61.7-1.3-1.40.9-1.0-0.9
Reaction time num false alarms AUC1.82.94.2-1.9-1.92.0-1.8-1.91.4-1.4-1.2
Reaction time trials correct on left0.30.61.41.21.2-1.20.20.30.0-0.1-0.0
Reaction time trials on left0.20.41.11.01.0-1.00.20.20.0-0.10.0
Reaction time mean1.01.63.9-2.0-2.01.80.30.2-0.60.70.7
Reaction time mean AUC0.81.22.6-1.6-1.61.40.50.4-0.80.80.9
Median of all reaction times0.60.91.9-1.4-1.41.20.40.4-0.70.70.7
Reaction time omissions1.92.77.3-2.7-2.72.5-0.6-0.70.1-0.00.4
Reaction time false alarm rate2.53.45.7-2.2-2.22.4-1.8-1.91.3-1.3-1.2
Reaction time premature initiation rate0.30.41.1-1.0-1.00.90.20.2-0.40.40.6
Reaction time premature initiations0.10.20.5-0.3-0.30.20.40.4-0.40.40.7
Std. dev. reaction times1.52.77.3-2.7-2.72.5-0.2-0.3-0.30.30.7
Reaction time trials completed0.20.41.11.01.0-1.00.20.20.0-0.10.0
Reaction time trials AUC0.20.30.80.90.9-0.9-0.00.00.2-0.3-0.1
Run reversals in cocaine runway, females0.30.30.8-0.9-0.90.70.30.2-0.40.40.3
Run reversals in cocaine runway, males2.52.52.8-1.6-1.61.7-1.6-1.71.4-1.4-1.5
Latency to leave start box in cocaine runway0.91.01.71.01.0-0.7-0.9-0.91.1-1.0-1.3
Latency to leave start box in cocaine runway, F1.51.82.81.31.3-0.9-1.2-1.21.5-1.4-1.7
Latency to leave start box in cocaine runway, M0.40.41.0-1.0-1.00.80.20.1-0.20.30.3
Std. dev. time between licks in bursts1.72.34.3-0.4-0.40.11.81.7-1.91.92.1
Total sessions with >9 infusions0.10.10.4-0.6-0.60.50.00.0-0.20.10.4
Short access day 1 total inactive lever presses1.01.32.30.30.30.1-1.5-1.51.5-1.5-1.3
Short access day 10 total inactive lever presses0.10.20.3-0.2-0.20.3-0.5-0.50.5-0.5-0.3
Short access day 1 total infusions0.00.00.10.20.2-0.2-0.0-0.00.1-0.10.3
Short access day 10 total infusions0.40.61.51.21.2-1.0-0.3-0.20.4-0.4-0.2
Short access total infusions0.10.10.3-0.0-0.0-0.00.20.2-0.20.20.6
Short access day 1 locomotion0.91.11.5-1.0-1.01.1-1.2-1.21.0-1.1-0.7
Short access day 10 total locomotion0.30.51.00.10.10.1-0.9-0.90.9-0.9-1.0
Short access total locomotion0.00.00.00.20.2-0.20.20.2-0.20.20.2
One hour access (0.3 mA shock)0.10.10.3-0.3-0.30.20.30.3-0.30.30.6
Compulsive drug intake0.70.81.10.80.8-0.91.01.1-0.90.90.6
One hour access (shock baseline)0.61.01.7-0.6-0.60.7-1.3-1.31.2-1.2-0.7
Social response proportion0.30.30.5-0.7-0.70.50.30.3-0.40.50.6
Social responses1.11.43.1-0.7-0.70.31.31.2-1.41.41.8
Social time0.20.30.9-0.9-0.90.7-0.3-0.30.1-0.20.4
Soleus weight2.05.89.7-0.1-0.10.6-3.1-3.03.1-3.1-2.9
Bone: stiffness0.00.10.1-0.3-0.40.30.00.0-0.10.10.3
Tibialis anterior weight2.99.917.51.91.9-1.3-3.4-3.24.0-3.9-4.2
Time to tail flick, vehicle, before self-admin1.71.83.00.90.9-0.5-1.4-1.41.6-1.5-1.7
Time to tail flick, vehicle, after self-admin0.60.81.31.11.1-0.8-0.7-0.70.8-0.9-0.9
Time to tail flick, test, before self-admin3.94.17.12.72.7-2.0-1.5-1.41.8-1.8-2.0
Time to tail flick, test, after self-admin0.91.01.31.11.1-0.7-1.0-1.01.1-1.1-0.8
Delta time to tail flick, vehicle, before/after SA0.00.00.10.30.3-0.3-0.1-0.10.0-0.1-0.1
Delta time to tail flick, test, before/after SA0.90.92.3-1.5-1.51.30.20.2-0.50.40.7
Tibia length0.10.20.4-0.1-0.10.2-0.7-0.60.6-0.7-0.5
Ambulatory time before self-admin0.10.10.10.40.4-0.3-0.2-0.20.2-0.3-0.2
Ambulatory time after self-admin0.40.50.90.40.4-0.1-0.9-0.80.8-0.9-0.9
Bone: tissue strength0.80.81.3-0.9-0.90.70.80.7-1.01.01.1
Total heroin consumption0.20.20.4-0.0-0.0-0.10.60.6-0.70.50.6
Bone: trabecular number0.50.81.40.10.1-0.21.21.1-1.21.21.1
Bone: trabecular spacing0.81.11.90.50.5-0.2-1.3-1.21.4-1.4-1.3
Bone: trabecular thickness0.50.60.9-0.6-0.60.50.80.7-0.90.90.9
Bone: trabecular tissue density0.40.51.31.10.8-1.10.60.7-0.40.40.2
Water consumed over 24 hours0.81.12.2-1.0-1.01.5-1.2-1.30.9-0.9-0.6
Number of responses in last shaping day1.71.93.2-0.6-0.60.9-1.8-1.81.6-1.7-1.3