Onecut1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	LHb	gene expression	Onecut1	0.4	0.13	9.5e-06	0.19	0.17	0.18	0.18	2.3e-05	9.0e-05	5.8e-05	4.2e-05
2	Liver	mRNA stability	Onecut1	0.05	0.03	1.6e-04	0.01	0.02	0.02	0.01	2.2e-02	4.1e-03	3.8e-03	4.7e-02
3	Brain	alternative polyA	XM_006243404.4	0.1	0.04	1.4e-08	0.07	0.1	0.1	0.1	2.4e-07	5.6e-10	1.5e-09	1.1e-09
4	Brain	alternative polyA	NM_022671.3	0.1	0.04	1.4e-08	0.07	0.1	0.1	0.1	2.0e-07	5.3e-10	6.4e-10	9.1e-10
5	Brain	gene expression	Onecut1	0.24	0.08	0.0e+00	0.22	0.21	0.21	0.22	9.2e-20	2.2e-19	2.1e-19	4.5e-20
6	LHb	isoform ratio	XM_006243404.4	0.2	0.1	1.7e-03	0.07	0.1	0.06	0.1	8.6e-03	2.8e-03	1.3e-02	3.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.0	0.0	0.2	0.4	0.2	0.1	-0.1	0.1	0.2
Area under the delay curve	1.3	1.4	3.4	1.8	0.8	-1.0	1.0	-0.9	1.2
BMI with tail	1.3	4.2	6.3	1.5	-1.0	-2.5	2.5	-2.3	2.0
BMI without tail	0.3	0.6	1.3	0.4	-1.1	-0.7	0.7	-0.9	0.3
Body weight	1.2	5.1	7.4	2.7	-0.3	-2.4	2.4	-2.2	2.6
Weight adjusted by age	3.8	4.3	5.7	1.9	0.8	-2.4	2.4	-2.3	2.2
Bone surface	0.8	1.4	2.7	0.5	-0.3	-1.6	1.6	-1.6	0.8
Bone volume	0.3	0.6	0.9	0.5	-0.3	-1.0	1.0	-1.0	0.6
Breakpoint value in progressive ratio session	0.6	0.6	1.1	0.4	0.3	-1.0	1.0	-0.9	0.8
Number of licking bursts	2.7	3.2	5.0	1.2	0.9	-2.2	2.2	-2.1	1.7
Context. condit. distance diff. score	0.3	0.3	0.6	0.3	-0.4	-0.8	0.8	-0.6	0.4
Locomotion velocity, session 1	0.1	0.1	0.2	-0.1	-0.3	-0.5	0.5	-0.4	0.1
Locomotion distance, session 1	0.3	0.4	1.2	0.3	1.1	0.6	-0.6	0.5	-0.0
Locomotion velocity, session 2	0.4	0.4	0.6	0.6	0.5	-0.8	0.8	-0.7	0.5
Locomotion distance, session 2	0.2	0.2	0.8	0.5	0.9	0.4	-0.4	0.3	0.1
Locomotion velocity, session 3	0.1	0.1	0.4	-0.5	-0.4	-0.0	0.0	-0.3	-0.6
Locomotion distance, session 3	1.8	2.0	3.0	-0.8	-0.7	1.7	-1.7	1.5	-1.6
Stereotopy head waving bouts, day 3	0.2	0.2	1.2	-1.1	-0.1	-0.3	0.3	-0.3	-0.1
Stereotopy head waving duration, day 3	0.5	0.6	2.2	-1.5	-0.6	-0.5	0.5	-0.4	-0.3
Locomotion velocity, session 7	0.2	0.2	0.4	-0.6	0.1	0.5	-0.5	0.6	-0.5
Locomotion distance, session 7	0.0	0.0	0.0	0.1	0.0	-0.0	0.0	-0.0	-0.0
Stereotopy head waving bouts, day 7	0.8	0.9	2.3	-1.5	-1.1	-0.3	0.3	-0.5	-1.2
Stereotopy head waving duration, day 7	0.7	0.8	1.9	-1.4	-1.0	-0.5	0.6	-0.7	-1.0
Locomotion velocity, session 8	0.3	0.4	0.8	-0.4	-0.4	-0.8	0.8	-0.9	-0.4
Locomotion distance, session 8	0.2	0.3	0.5	0.7	0.5	-0.6	0.6	-0.6	0.5
Degree of sensitization distance	1.5	1.5	2.2	0.6	1.0	-1.5	1.5	-1.2	1.4
Degree of sensitization stereotypy	0.4	0.5	1.1	-0.8	-1.0	-0.3	0.3	-0.5	-0.8
Conditioned locomotion	0.9	1.0	2.7	1.6	1.3	0.5	-0.5	0.4	1.0
Cocaine response after cond. corrected	1.8	2.0	3.6	-0.6	-1.9	-1.7	1.7	-1.6	0.2
Cocaine response after cond. not corrected	2.3	2.5	4.4	0.0	-1.2	-2.1	2.1	-1.9	1.0
Cocaine response before conditioning	2.7	3.3	5.6	2.4	1.9	-1.4	1.4	-1.3	2.1
Saline control response	0.1	0.1	0.4	-0.6	-0.5	-0.0	0.0	-0.2	-0.5
Bone: connectivity density	0.3	0.5	0.9	-0.1	0.8	0.9	-0.9	0.8	-0.4
Bone: cortical apparent density	3.4	4.5	5.6	-2.1	-1.4	2.3	-2.3	2.4	-2.2
Bone: cortical area	0.1	0.1	0.5	-0.4	-0.7	-0.3	0.3	-0.1	0.2
Bone: cortical porosity	1.3	1.4	3.6	1.7	1.9	0.1	-0.1	0.2	1.4
Bone: cortical porosity	1.2	1.3	3.8	1.6	1.9	0.2	-0.2	0.2	1.2
Bone: cortical thickness	1.7	2.7	4.6	-1.6	-0.7	1.9	-1.8	2.1	-1.4
Bone: cortical thickness	0.2	0.2	0.4	-0.5	-0.4	0.5	-0.5	0.7	-0.3
Bone: cortical tissue density	3.1	4.0	5.1	-2.0	-1.3	2.1	-2.1	2.3	-2.1
Condit. Reinf. active minus inactive responses	0.2	0.2	1.2	1.1	0.2	0.1	-0.1	0.2	0.3
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.6	-0.1	-0.8	-0.3	0.3	-0.0	-0.0
Condit. Reinf. active responses	0.4	0.5	2.2	1.5	0.6	-0.2	0.2	-0.2	0.5
Condit. Reinf. inactive responses	0.7	0.8	2.1	1.4	1.3	-0.3	0.3	-0.5	0.6
Incentive salience index mean	2.4	2.9	7.0	2.6	1.8	-1.1	1.1	-1.0	1.9
Condit. Reinf. lever presses	5.8	7.8	13.2	3.6	3.3	-1.9	1.9	-2.0	3.3
Condit. Reinf. active minus inactive responses	1.5	1.8	5.7	-1.1	-2.4	-1.0	1.0	-1.1	-0.8
Condit. Reinf. active-inactive response ratio	1.9	2.0	6.4	-1.9	-2.5	-0.4	0.4	-0.5	-1.3
Condit. Reinf. active responses	0.9	1.2	1.9	0.7	-0.9	-1.4	1.4	-1.4	0.5
Condit. Reinf. inactive responses	2.3	2.9	6.1	2.5	2.1	-1.0	1.0	-0.9	1.9
Condit. Reinf. lever presses	1.1	1.5	2.6	0.6	-0.3	-1.6	1.6	-1.6	0.8
Condit. Reinf. lever reinforcers received	0.7	1.0	1.5	0.7	-0.9	-1.2	1.2	-1.2	0.5
Conditioned reinforcement - actives	0.3	0.3	0.7	0.6	0.5	-0.4	0.4	-0.4	0.8
Conditioned reinforcement - inactives	0.0	0.0	0.0	-0.1	0.1	0.2	-0.2	0.2	-0.2
Conditioned locomotion	0.3	0.4	0.6	0.4	0.5	0.7	-0.7	0.7	0.5
Patch foraging indifference point 0 sec	0.3	0.5	1.6	-0.8	-1.3	-0.2	0.2	-0.3	-0.8
Patch foraging indifference point AUC	1.2	1.4	4.1	1.5	2.0	0.6	-0.6	0.6	0.9
Delay disc. indifference point, 0s delay	0.1	0.1	0.7	0.8	0.2	0.0	-0.0	-0.1	-0.1
Delay disc. indifference point, 16s delay	0.2	0.2	0.4	-0.1	0.4	0.5	-0.5	0.6	-0.2
Delay disc. indifference point, 2s delay	0.2	0.3	0.7	0.9	0.4	-0.5	0.5	-0.3	0.4
Delay disc. indifference point, 24s delay	0.3	0.3	0.5	0.7	0.6	0.4	-0.4	0.5	0.2
Delay disc. indifference point, 4s delay	0.4	0.4	0.9	1.0	-0.3	-0.7	0.7	-0.6	0.4
Delay disc. indifference point, 8s delay	3.4	3.5	5.4	2.3	0.9	-2.0	2.0	-2.0	1.8
Indifference point function ln k	1.0	1.4	3.6	-0.9	-1.9	-1.1	1.1	-1.1	-0.7
Indifference point function log k	1.0	1.4	3.6	-0.9	-1.9	-1.1	1.1	-1.1	-0.7
Patch foraging total patch changes 0 sec	0.3	0.5	1.5	-0.8	-1.2	-0.1	0.1	-0.2	-0.7
Patch foraging total patch changes 12 sec	0.7	0.9	1.3	0.0	1.1	1.2	-1.2	1.1	-0.1
Patch foraging total patch changes 18 sec	0.1	0.1	0.1	-0.3	0.3	0.4	-0.4	0.3	-0.1
Patch foraging total patch changes 24 sec	0.6	0.8	1.3	-0.4	-1.1	0.9	-0.9	0.5	-1.1
Patch foraging total patch changes 6 sec	0.7	1.1	1.7	-0.9	-0.8	1.1	-1.1	0.9	-1.3
Patch foraging time to switch 0 sec	0.4	0.7	1.5	-1.2	-0.0	0.8	-0.8	0.9	-0.7
Patch foraging water rate 0 sec	0.8	1.4	3.0	0.2	-1.7	-1.3	1.3	-1.3	0.1
Patch foraging water rate 12 sec	1.1	1.7	4.2	-0.5	-2.0	-1.3	1.3	-1.4	-0.6
Patch foraging water rate 18 sec	1.1	1.5	4.5	-0.8	-2.1	0.8	-0.8	0.7	-1.5
Patch foraging water rate 24 sec	0.6	0.8	2.4	-1.0	-1.6	0.2	-0.2	0.2	-1.2
Patch foraging water rate 6 sec	0.8	1.2	2.2	0.6	-0.8	-1.4	1.4	-1.5	0.3
Seeking ratio, delayed vs. immediate footshock	3.3	3.8	6.7	1.3	-0.0	-2.4	2.4	-2.6	1.5
Distance traveled before self-admin	1.0	1.1	2.0	0.7	0.6	-1.4	1.4	-1.1	0.8
Distance traveled after self-admin	2.2	2.4	4.3	1.0	-0.3	-2.1	2.1	-1.8	1.3
Extensor digitorum longus weight	0.6	2.5	4.4	1.1	-1.4	-1.8	1.8	-2.1	0.9
Bone: elastic displacement	0.2	0.2	0.3	0.2	-0.4	0.6	-0.6	0.6	-0.2
Bone: elastic work	0.1	0.1	0.2	0.2	-0.2	0.4	-0.4	0.5	-0.2
Bone: endosteal estimation	3.3	7.2	12.6	1.7	-0.2	-3.3	3.3	-3.5	2.3
Bone: endosteal perimeter	1.8	3.7	5.6	1.4	0.2	-2.3	2.3	-2.4	2.0
Epididymis fat weight	2.1	4.8	9.0	-0.1	1.3	3.0	-3.0	2.9	-1.0
Delta time in closed arm before/after self-admin	0.4	0.4	0.7	0.8	0.7	0.5	-0.5	0.7	0.5
Delta time in open arm before/after self-admin	4.2	4.0	8.9	-3.0	-1.5	1.5	-1.5	1.1	-2.7
Diff in mean of infusions in LGA sessions	3.6	4.0	5.1	1.6	1.3	-2.3	2.3	-2.0	2.3
Delay discount exponential model param	1.4	1.5	3.5	-1.9	-0.7	1.1	-1.1	1.0	-1.2
Extinction: sum of active levers before priming	0.2	0.2	0.7	-0.8	0.5	-0.1	0.1	0.1	-0.0
Active lever presses in extinction session 6	0.5	0.5	0.9	-0.4	-0.3	-0.9	0.9	-0.9	0.2
Bone: final force	0.1	0.2	0.3	0.5	-0.4	-0.4	0.4	-0.5	0.5
Bone: final moment	0.0	0.1	0.1	0.3	-0.3	-0.1	0.1	-0.2	0.3
Food consumed during 24 hour testing period	4.2	5.0	9.2	0.7	-0.4	-3.0	3.0	-2.8	1.8
Glucose	1.0	1.5	3.6	-1.9	-1.2	0.8	-0.8	0.7	-1.3
Heart weight	0.2	0.3	0.9	0.9	-0.7	0.3	-0.4	0.4	-0.1
Delay discount hyperbolic model param	1.1	1.1	2.7	-1.6	-0.5	1.0	-1.0	0.9	-1.0
Intermittent access intake day 1-15 change	0.2	0.2	0.8	0.1	0.9	-0.2	0.2	-0.1	0.4
Intermittent access intake escalation	0.9	0.9	1.1	0.5	1.0	-1.1	1.1	-0.9	0.9
Intermittent access intake escalation 2	1.5	1.5	2.2	0.9	0.9	-1.5	1.5	-1.3	1.2
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.1	0.0	0.2	0.1	-0.1	0.2	-0.1
Intermitt. access day 15 inactive lever presses	0.7	0.8	1.1	0.6	1.0	1.1	-1.1	1.1	0.2
Intermitt. access escalation Index	1.3	1.2	2.1	0.6	0.2	-1.4	1.4	-1.1	1.1
Intermittent access day 1 total infusions	0.8	0.9	1.5	-1.2	-0.6	1.1	-1.1	1.0	-0.4
Intermittent access day 15 total infusions	0.2	0.2	0.4	-0.6	0.6	0.2	-0.2	0.3	0.4
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.8	0.1	0.5	-0.3	0.3	-0.2	0.9
Intermittent access total infusions	0.2	0.2	1.0	-1.0	-0.0	0.2	-0.2	0.1	0.2
Intermittent access day 1 locomotion	1.4	1.5	2.9	-0.6	0.3	1.7	-1.7	1.6	-0.3
Intermittent access day 15 total locomotion	0.5	0.5	0.9	-0.6	-0.0	1.0	-1.0	0.8	-0.2
Intermittent access total locomotion	0.1	0.2	0.4	-0.7	-0.5	0.3	-0.3	0.2	-0.0
Intermittent access standard deviation	2.0	2.1	3.9	1.6	2.0	-1.0	1.0	-0.9	1.8
Left kidney weight	0.3	1.0	2.6	1.6	-0.2	-0.8	0.8	-1.0	1.0
Right kidney weight	0.3	1.0	2.9	1.7	0.2	-0.6	0.6	-0.8	1.2
Cocaine induced anxiety	0.3	0.3	0.8	0.9	0.7	-0.1	0.1	-0.0	0.7
Post-drug Anxiety	0.7	0.8	1.5	-0.1	0.6	1.2	-1.2	1.1	-0.5
Baseline Anxiety	2.7	2.8	3.6	-1.7	-0.8	1.9	-1.9	1.7	-1.9
Tail length	0.0	0.1	0.7	0.8	0.1	0.1	-0.1	-0.1	0.1
Length with tail	0.4	1.5	4.6	2.1	0.3	-0.9	0.9	-0.9	1.4
Length without tail	1.9	4.2	6.8	2.3	1.0	-2.1	2.1	-1.9	2.6
Times rat made contact with spout	1.3	1.5	2.6	0.7	-0.2	-1.6	1.6	-1.4	1.0
Lifetime Intake	0.5	0.5	1.4	-1.2	0.1	0.8	-0.8	0.7	-0.1
Liver weight, left	0.4	0.7	1.5	-0.3	-1.2	-0.8	0.8	-1.0	0.2
Liver weight, right	0.3	0.5	2.6	-0.2	-1.6	-0.1	0.1	-0.4	-0.2
Locomotor activity	0.3	0.4	0.7	0.8	0.2	-0.6	0.6	-0.6	0.8
Locomotor testing distance	0.1	0.2	0.3	0.3	-0.1	-0.5	0.5	-0.6	0.2
Locomotor testing rearing	0.1	0.1	0.3	-0.3	-0.6	-0.1	0.1	-0.0	-0.4
Locomotion in novel chamber	0.3	0.3	0.5	-0.7	-0.3	0.6	-0.6	0.6	-0.4
Locomotion in novel chamber post-restriction	0.1	0.2	0.4	-0.4	-0.6	0.4	-0.4	0.2	-0.4
Fecal boli incidents, locomotor time 1	3.6	4.0	6.7	2.2	2.2	-1.7	1.7	-1.3	2.6
Change in fecal boli incidents, locomotor task	2.4	2.2	5.8	-2.2	-2.4	-0.3	0.3	-0.6	-1.5
Time >=10cm from walls, locomotor time 1	1.1	1.1	1.5	0.6	0.9	-1.2	1.2	-1.2	1.1
Bouts of movement, locomotor time 1	0.1	0.2	0.4	0.6	0.5	-0.1	0.0	-0.1	0.5
Total resting periods, locomotor time 1	0.0	0.0	0.1	0.3	0.3	-0.1	0.1	-0.1	0.3
Rest time, locomotor task time 1	0.2	0.2	0.8	-0.5	-0.9	-0.3	0.3	-0.1	-0.1
Distance moved, locomotor task time 1	0.4	0.4	0.7	-0.3	0.0	0.8	-0.8	0.7	-0.8
Vertical activity count, locomotor time 1	0.1	0.1	0.2	0.1	0.3	0.4	-0.4	0.4	-0.3
Time >=10cm from walls, locomotor time 2	0.6	0.6	1.4	0.9	1.2	-0.4	0.4	-0.3	0.9
Bouts of movement, locomotor time 2	0.4	0.4	0.9	-0.2	0.3	0.9	-0.9	0.9	-0.3
Total resting periods, locomotor time 2	0.3	0.3	0.6	-0.3	0.2	0.7	-0.7	0.7	-0.2
Rest time, locomotor task time 2	0.7	0.8	1.9	-1.4	0.1	0.8	-0.8	1.1	-0.7
Distance moved, locomotor task time 2	0.2	0.2	0.6	-0.3	-0.6	0.3	-0.3	0.2	-0.8
Vertical activity count, locomotor time 2	0.2	0.2	0.3	0.6	0.6	-0.4	0.4	-0.3	0.3
Light reinforcement 1	1.6	2.9	5.0	2.2	0.9	-1.6	1.6	-1.6	1.9
Light reinforcement 2	0.6	0.8	2.7	0.7	1.6	-0.4	0.4	-0.3	1.2
Bone: marrow area	3.4	7.3	12.7	1.7	-0.2	-3.4	3.4	-3.6	2.4
Bone: maximum diameter	3.2	5.8	9.9	1.2	-0.6	-3.1	3.1	-3.0	2.1
Bone: maximum force	0.5	0.8	1.2	0.9	-0.3	-1.0	1.0	-1.1	1.0
Bone: maximum moment	0.3	0.5	0.7	0.7	-0.2	-0.7	0.7	-0.7	0.8
Mean time between licks in bursts	0.4	0.6	3.3	0.2	1.8	0.1	-0.1	0.2	0.5
Mean num. licks in bursts	0.9	1.1	1.2	-0.8	-1.1	1.1	-1.1	1.1	-1.0
Cd content in liver	0.1	0.1	0.5	0.7	0.3	0.2	-0.2	0.0	0.2
Co content in liver	0.7	0.8	2.3	1.5	1.1	0.5	-0.5	0.6	0.8
Cu content in liver	0.2	0.3	0.4	0.5	-0.3	0.6	-0.7	0.6	0.1
Fe content in liver	0.1	0.1	0.2	0.0	-0.1	-0.3	0.3	-0.5	-0.4
K content in liver	0.2	0.2	1.0	0.2	-1.0	0.0	-0.0	-0.2	-0.3
Mg content in liver	0.8	0.8	1.1	1.0	-1.0	-0.8	0.8	-1.1	0.5
Mn content in liver	0.7	0.8	2.1	0.9	1.4	-0.2	0.2	-0.1	1.2
Na content in liver	0.4	0.4	0.6	0.7	0.3	-0.6	0.6	-0.8	0.7
Rb content in liver	0.9	1.1	5.0	-0.6	-2.2	-0.4	0.4	-0.7	-0.8
Se content in liver	0.6	0.7	1.2	-0.7	0.4	1.0	-1.0	1.1	-0.5
Sr content in liver	2.0	1.8	5.3	1.4	2.3	-0.7	0.7	-0.7	1.4
Zn content in liver	0.4	0.4	1.1	1.0	0.7	0.4	-0.4	0.5	0.6
Bone: minimum diameter	0.2	0.3	0.9	0.7	0.2	-0.4	0.4	-0.3	1.0
Time in familiar zone, hab. session 1	1.9	1.7	2.5	1.4	1.2	-1.3	1.3	-1.2	1.6
Time in novel zone, hab. session 1	1.8	1.7	2.6	-1.6	-1.4	1.0	-1.0	1.1	-1.6
Total zone transitions, hab. session 1	1.5	2.1	3.6	-0.4	0.7	1.9	-1.9	1.9	-1.1
Total locomotion distance, hab. session 1	2.2	3.1	5.0	-1.0	-0.1	2.2	-2.2	2.1	-1.7
Locomotion velocity, hab. session 1	1.1	1.5	2.7	-0.6	0.3	1.6	-1.6	1.5	-1.1
Time in familiar zone, hab. session 2	0.2	0.2	0.3	0.1	-0.5	-0.5	0.5	-0.5	-0.1
Time in novel zone, hab. session 2	0.1	0.1	0.3	-0.6	-0.2	0.1	-0.1	0.1	-0.1
Total zone transitions, hab. session 2	0.8	1.0	1.7	0.9	1.3	1.1	-1.1	0.9	-0.0
Total locomotion distance, hab. session 2	1.0	1.3	2.4	1.0	1.6	1.3	-1.3	1.1	0.1
Locomotion velocity, hab. session 2	1.3	1.7	3.6	1.1	1.9	1.4	-1.4	1.3	0.3
Novel to familiar place preference ratio	0.3	0.3	0.6	0.8	-0.2	-0.5	0.5	-0.6	0.7
Novelty place preference	0.7	0.7	1.0	1.0	-0.3	-0.9	0.9	-0.9	1.0
Time in novel zone, NPP test	0.9	0.9	1.3	0.6	-0.9	-1.2	1.1	-1.2	0.8
Total zone transitions, NPP test	0.2	0.3	0.5	0.2	0.1	0.7	-0.7	0.6	-0.4
Total locomotion distance, NPP test	0.2	0.3	0.4	0.5	0.6	0.6	-0.6	0.4	-0.0
Locomotion velocity, NPP test	0.5	0.7	1.4	0.6	1.2	1.0	-1.0	0.8	-0.1
Intraocular pressure	0.4	0.6	1.0	-1.0	-0.9	0.5	-0.5	0.6	-1.0
Delta distance traveled before/after self-admin	0.5	0.5	1.1	0.3	-1.1	-0.7	0.7	-0.7	0.4
Delta ambulatory time before/after self-admin	0.5	0.5	0.8	0.1	-0.9	-0.9	0.8	-0.8	0.5
Parametrial fat weight	0.4	0.8	1.1	-0.8	-0.6	1.0	-1.0	1.0	-1.0
Pavlov. Cond. lever latency	6.4	8.1	14.8	-3.9	-3.5	1.9	-1.9	2.0	-3.3
Pavlov. Cond. magazine entry latency	6.9	8.9	22.7	4.3	4.8	-0.5	0.5	-0.5	3.3
Pavlov. Cond. change in total contacts	5.2	5.6	12.6	3.6	3.4	-0.7	0.7	-0.8	2.7
Pavlov. Cond. index score	6.9	8.8	19.6	4.4	4.4	-0.9	0.9	-1.0	3.4
Pavlov. Cond. latency score	6.3	8.0	17.4	4.2	4.2	-1.0	1.0	-1.1	3.2
Pavlov. Cond. lever contacts	5.3	6.2	13.0	3.6	3.1	-1.4	1.4	-1.5	2.9
Pavlov. Cond. magazine entry number	4.7	5.9	14.7	-3.7	-3.8	0.0	-0.0	0.1	-2.6
Pavlov. Cond. intertrial magazine entries	2.1	2.5	7.5	-1.7	-2.7	0.3	-0.3	0.1	-2.0
Pavlov. Cond. lever-magazine prob. diff.	7.3	9.1	20.3	4.5	4.3	-1.0	1.0	-1.2	3.5
Pavlov. Cond. response bias	4.5	5.5	13.8	3.7	3.3	-0.5	0.5	-0.6	2.7
Pavlov. Cond. lever latency	1.9	2.5	3.6	-1.7	0.0	1.8	-1.8	1.9	-1.4
Pavlov. Cond. magazine entry latency	0.4	0.5	1.6	0.1	1.3	0.7	-0.6	0.7	0.1
Pavlov. Cond. change in total contacts	0.3	0.4	0.8	0.9	-0.1	-0.7	0.7	-0.7	0.7
Pavlov. Cond. index score	0.9	1.2	1.6	1.3	0.8	-1.1	1.1	-1.1	1.1
Pavlov. Cond. latency score	1.0	1.3	1.7	1.1	0.6	-1.3	1.3	-1.3	1.1
Pavlov. Cond. lever contacts	2.4	3.3	4.5	2.0	0.2	-2.0	2.0	-2.1	1.7
Pavlov. Cond. magazine entry number	0.0	0.1	0.3	-0.0	-0.6	-0.1	0.1	-0.0	-0.1
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.4	0.1	0.5	-0.6	0.6	-0.5	0.6
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.3	1.9	1.4	1.1	-1.0	1.0	-1.0	1.3
Pavlov. Cond. response bias	0.9	1.2	2.9	1.7	0.8	-0.9	0.9	-1.0	1.2
Time in closed arm before self-admin	0.8	0.9	1.2	1.0	1.1	-0.8	0.8	-0.8	1.1
Time in closed arm after self-admin	0.4	0.4	1.2	0.6	1.1	0.3	-0.3	0.4	0.6
Time in open arm before self-admin	1.3	1.4	2.3	0.8	-0.5	-1.5	1.5	-1.3	1.2
Time in open arm after self-admin	1.0	1.1	2.8	-1.6	-1.7	-0.1	0.1	-0.3	-1.1
Bone: periosteal estimation	1.7	3.5	5.9	0.8	-0.8	-2.4	2.4	-2.4	1.6
Bone: periosteal perimeter	0.7	1.1	1.9	0.3	-0.8	-1.3	1.3	-1.4	0.7
Bone: post-yield work	2.5	3.4	6.0	1.6	0.1	-2.2	2.2	-2.4	1.5
Progressive ratio test 1 active lever presses	0.3	0.3	1.4	-1.2	-0.5	-0.1	0.1	0.0	0.3
Progressive ratio test 1 breakpoint	0.2	0.2	0.9	-1.0	-0.3	-0.3	0.3	-0.1	0.5
Progressive ratio test 1 inactive lever presses	0.2	0.2	0.8	-0.9	0.1	0.3	-0.3	0.4	0.0
Progressive ratio test 2 active lever presses	0.1	0.1	0.4	-0.6	-0.1	0.1	-0.1	0.1	0.3
Progressive ratio test 2 breakpoint	0.1	0.2	0.8	-0.9	-0.2	-0.0	0.0	-0.0	0.2
Progressive ratio test 2 inactive lever presses	0.4	0.5	0.7	-0.8	0.7	0.8	-0.8	0.8	0.0
Incentive Sensitization - Responses	0.3	0.3	0.8	0.5	0.9	-0.0	0.0	-0.1	0.7
Incentive Sensitization - Breakpoint	0.2	0.2	0.8	0.5	0.9	0.2	-0.2	0.1	0.6
Sum of active levers in priming session hrs 5-6	0.4	0.4	0.8	-0.8	-0.9	-0.5	0.5	-0.5	-0.4
Progressive ratio	2.0	2.4	4.3	2.1	1.7	-1.1	1.1	-0.9	1.9
Food seeking constrained by brief footshock	2.5	3.1	5.4	0.3	-1.5	-2.3	2.3	-2.2	0.4
Seeking ratio, punishment vs. effort	1.6	1.9	6.7	-1.4	-2.6	-0.4	0.4	-0.6	-1.4
Retroperitoneal fat weight	0.7	2.3	4.6	-0.0	-0.2	2.1	-2.1	2.1	-0.7
Reaction time number correct	0.1	0.1	0.4	-0.4	-0.2	-0.4	0.4	-0.6	-0.3
Reaction time mean minus median	1.0	1.4	2.2	-0.8	-0.7	1.5	-1.5	1.4	-0.9
Reaction time mean minus median AUC	0.9	1.1	1.5	-0.9	-0.8	1.2	-1.2	1.2	-0.9
Reaction time num false alarms	1.1	1.6	2.5	-1.6	-0.5	1.3	-1.3	1.3	-1.3
Reaction time num false alarms AUC	1.1	1.5	2.6	-1.6	-0.6	1.2	-1.2	1.1	-1.5
Reaction time trials correct on left	0.1	0.1	0.4	-0.4	-0.2	-0.4	0.4	-0.6	-0.3
Reaction time trials on left	0.1	0.1	0.3	-0.5	-0.2	-0.3	0.3	-0.5	-0.4
Reaction time mean	0.7	0.9	1.7	-0.6	-0.1	1.3	-1.3	1.3	-0.4
Reaction time mean AUC	0.6	0.8	1.3	-0.6	-0.4	1.1	-1.2	1.1	-0.5
Median of all reaction times	0.6	0.9	1.7	-0.5	0.3	1.3	-1.3	1.3	-0.3
Reaction time omissions	1.4	1.9	2.8	-1.2	-0.3	1.7	-1.7	1.5	-1.4
Reaction time false alarm rate	1.0	1.5	1.9	-1.2	-0.5	1.3	-1.3	1.4	-1.3
Reaction time premature initiation rate	0.0	0.0	0.1	0.4	-0.2	0.1	-0.1	0.1	-0.2
Reaction time premature initiations	0.0	0.0	0.1	0.1	-0.3	-0.1	0.1	-0.2	-0.3
Std. dev. reaction times	1.4	2.0	3.3	-0.9	-0.7	1.8	-1.8	1.7	-1.1
Reaction time trials completed	0.1	0.1	0.3	-0.5	-0.2	-0.3	0.3	-0.5	-0.4
Reaction time trials AUC	0.1	0.2	0.4	-0.6	-0.3	-0.4	0.4	-0.6	-0.3
Run reversals in cocaine runway, females	0.6	0.6	1.3	-1.2	-0.5	0.6	-0.6	0.7	-0.7
Run reversals in cocaine runway, males	0.5	0.4	1.0	0.2	-1.0	-0.7	0.7	-0.7	0.1
Latency to leave start box in cocaine runway	0.4	0.4	0.9	0.9	0.2	-0.6	0.6	-0.7	0.7
Latency to leave start box in cocaine runway, F	0.3	0.3	0.5	0.7	0.4	-0.5	0.5	-0.5	0.6
Latency to leave start box in cocaine runway, M	0.1	0.1	0.5	0.7	0.1	0.2	-0.2	-0.0	0.2
Std. dev. time between licks in bursts	2.1	2.5	3.7	1.9	1.9	-1.2	1.2	-1.4	1.6
Total sessions with >9 infusions	0.3	0.3	1.4	-1.2	0.4	-0.2	0.2	-0.0	0.3
Short access day 1 total inactive lever presses	0.0	0.0	0.0	-0.1	-0.2	-0.0	0.0	-0.1	-0.0
Short access day 10 total inactive lever presses	0.1	0.1	0.3	0.4	0.6	0.0	-0.0	-0.1	-0.2
Short access day 1 total infusions	0.3	0.4	1.4	-0.1	1.2	0.3	-0.3	0.3	0.6
Short access day 10 total infusions	0.3	0.4	1.8	-1.3	-0.1	0.4	-0.4	0.3	0.0
Short access total infusions	1.3	1.4	2.8	-1.7	0.2	1.4	-1.4	1.3	-0.6
Short access day 1 locomotion	0.2	0.2	0.8	0.5	0.5	-0.3	0.3	-0.1	0.9
Short access day 10 total locomotion	0.1	0.1	0.3	0.3	0.4	-0.3	0.3	-0.3	0.5
Short access total locomotion	0.4	0.4	1.3	0.2	1.1	0.3	-0.3	0.4	0.8
One hour access (0.3 mA shock)	0.4	0.4	1.0	-1.0	-0.7	0.6	-0.6	0.5	-0.3
Compulsive drug intake	0.2	0.2	0.9	-0.9	-0.4	-0.3	0.3	-0.2	-0.4
One hour access (shock baseline)	0.2	0.2	0.5	0.3	0.6	0.2	-0.2	0.2	0.7
Social response proportion	0.4	0.5	0.6	-0.7	-0.5	0.8	-0.8	0.8	-0.6
Social responses	0.5	0.6	1.5	1.0	1.2	-0.3	0.3	-0.2	1.0
Social time	0.1	0.1	0.3	-0.3	-0.6	-0.0	0.0	-0.1	-0.3
Soleus weight	5.3	15.4	27.0	3.0	-1.6	-4.8	4.8	-5.2	2.9
Bone: stiffness	0.4	0.6	2.3	-0.9	-1.5	-0.0	0.0	-0.2	-0.7
Tibialis anterior weight	3.0	10.3	19.9	0.4	-2.3	-4.1	4.1	-4.5	1.4
Time to tail flick, vehicle, before self-admin	0.6	0.6	1.6	-0.9	-1.3	-0.4	0.4	-0.6	-0.6
Time to tail flick, vehicle, after self-admin	1.7	1.9	3.6	-0.2	-0.6	-1.9	1.9	-1.7	0.8
Time to tail flick, test, before self-admin	0.3	0.3	0.6	0.8	0.7	0.3	-0.3	0.4	0.4
Time to tail flick, test, after self-admin	1.4	1.4	1.8	1.1	1.3	-1.3	1.3	-1.0	1.1
Delta time to tail flick, vehicle, before/after SA	0.8	0.8	1.4	0.7	0.4	-1.2	1.2	-1.0	0.8
Delta time to tail flick, test, before/after SA	1.6	1.4	2.7	0.3	0.2	-1.6	1.7	-1.5	0.8
Tibia length	1.3	3.7	6.9	1.8	0.8	-2.0	2.0	-1.8	2.6
Ambulatory time before self-admin	0.7	0.7	1.9	0.8	1.4	-0.6	0.6	-0.3	0.9
Ambulatory time after self-admin	1.5	1.6	3.0	0.6	-0.3	-1.7	1.7	-1.4	1.0
Bone: tissue strength	1.4	1.3	2.6	-1.6	-1.0	0.9	-0.9	1.1	-1.3
Total heroin consumption	1.3	1.5	3.0	0.1	-0.8	-1.7	1.7	-1.5	0.5
Bone: trabecular number	0.3	0.5	1.5	0.9	1.2	-0.1	0.1	-0.2	0.7
Bone: trabecular spacing	1.7	2.3	3.8	-1.0	-0.2	1.9	-1.9	1.9	-1.3
Bone: trabecular thickness	0.0	0.0	0.0	0.0	-0.2	-0.1	0.1	0.1	0.2
Bone: trabecular tissue density	0.8	1.1	3.4	-1.3	-1.8	0.5	-0.5	0.5	-0.9
Water consumed over 24 hours	2.1	2.6	4.2	1.0	-0.1	-2.0	2.0	-2.0	1.4
Number of responses in last shaping day	4.6	4.8	8.4	2.1	1.9	-2.2	2.2	-1.6	2.9