Hub : Genes

Onecut1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	mRNA stability	Onecut1	0.05	0.03	2.8e-04	0.01	0.01	0.01	0.01	2.5e-02	1.7e-02	1.5e-02	3.6e-02
2	LHb	gene expression	Onecut1	0.29	0.14	6.4e-04	0.2	0.12	0.09	0.14	1.7e-05	1.1e-03	3.1e-03	4.2e-04
3	Brain	gene expression	Onecut1	0.22	0.09	3.5e-12	0.11	0.13	0.15	0.15	8.7e-11	6.3e-12	1.1e-13	5.3e-14
4	NAcc	gene expression	Onecut1	0.02	0.01	7.6e-03	0	0.01	0	0	2.9e-01	3.8e-02	2.2e-01	1.3e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.2	0.3	0.9	1.0	0.4	0.2	0.1
Area under the delay curve	0.8	1.2	2.2	1.4	1.5	-0.9	0.1
BMI with tail	0.6	2.1	5.6	-0.7	1.3	-2.4	0.7
BMI without tail	0.3	1.4	3.2	0.8	1.8	-1.3	0.6
Body weight	0.9	4.1	8.3	0.7	2.9	-2.3	1.5
Weight adjusted by age	0.8	2.4	4.9	0.8	1.6	-2.2	1.1
Bone surface	0.3	0.7	2.4	0.3	0.4	-1.6	-0.3
Bone volume	0.1	0.3	0.6	0.5	0.5	-0.8	-0.0
Breakpoint value in progressive ratio session	0.3	0.6	1.5	0.5	0.6	-1.2	0.5
Number of licking bursts	0.7	2.2	4.1	1.8	1.2	-2.0	0.2
Context. condit. distance diff. score	0.1	0.1	0.1	0.2	0.3	-0.3	0.3
Locomotion velocity, session 1	0.1	0.2	0.4	-0.3	-0.1	-0.4	-0.6
Locomotion distance, session 1	0.2	0.2	0.8	0.9	0.2	0.3	-0.0
Locomotion velocity, session 2	0.4	0.5	0.7	0.7	0.7	-0.8	-0.5
Locomotion distance, session 2	0.4	0.6	1.9	1.4	0.5	-0.1	-0.6
Locomotion velocity, session 3	0.4	0.4	1.3	-0.3	-0.4	-0.3	-1.1
Locomotion distance, session 3	0.9	1.1	2.1	-0.5	-0.8	1.5	-1.1
Stereotopy head waving bouts, day 3	0.6	0.7	1.8	-1.3	-1.0	-0.2	0.4
Stereotopy head waving duration, day 3	0.8	1.0	2.2	-1.5	-1.3	-0.2	0.0
Locomotion velocity, session 7	0.3	0.3	0.6	-0.1	-0.7	0.8	-0.3
Locomotion distance, session 7	0.0	0.1	0.2	0.4	0.0	0.0	-0.3
Stereotopy head waving bouts, day 7	0.9	1.1	2.6	-0.4	-1.1	-0.4	-1.6
Stereotopy head waving duration, day 7	1.3	1.6	4.3	-0.3	-1.3	-0.6	-2.1
Locomotion velocity, session 8	1.1	1.3	3.5	1.0	-0.3	-0.9	-1.9
Locomotion distance, session 8	0.4	0.6	1.4	1.2	0.6	-0.6	-0.4
Degree of sensitization distance	0.7	0.8	1.1	1.0	0.6	-1.0	0.7
Degree of sensitization stereotypy	0.7	0.7	2.3	-0.0	-0.6	-0.5	-1.5
Conditioned locomotion	1.2	1.4	3.0	0.6	1.5	0.5	1.7
Cocaine response after cond. corrected	0.9	1.4	2.9	-1.7	-0.6	-1.5	-0.3
Cocaine response after cond. not corrected	0.7	1.1	3.0	-1.1	0.0	-1.7	0.4
Cocaine response before conditioning	3.1	3.7	5.8	2.3	2.4	-1.3	1.4
Saline control response	0.3	0.4	0.9	-0.9	-0.8	0.0	-0.3
Bone: connectivity density	0.3	0.4	1.3	1.1	-0.0	0.6	-0.2
Bone: cortical apparent density	2.7	4.3	6.5	-2.1	-2.3	2.5	-1.0
Bone: cortical area	0.6	1.0	2.4	-1.6	-0.7	0.3	0.9
Bone: cortical porosity	2.2	2.4	4.6	1.4	1.7	0.2	2.1
Bone: cortical porosity	2.1	2.3	4.7	1.3	1.7	0.2	2.2
Bone: cortical thickness	2.3	3.9	7.3	-2.0	-2.1	2.7	0.2
Bone: cortical thickness	0.4	0.5	1.1	-1.0	-0.4	0.4	0.7
Bone: cortical tissue density	2.5	4.0	6.1	-1.9	-2.2	2.5	-1.1
Condit. Reinf. active minus inactive responses	1.1	1.2	3.3	1.8	1.1	0.2	-0.5
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	-0.2	-0.0	0.1	-0.2
Condit. Reinf. active responses	1.6	2.0	5.5	2.3	1.4	-0.3	-0.7
Condit. Reinf. inactive responses	1.6	2.1	5.8	2.4	1.4	-0.7	-0.6
Incentive salience index mean	3.4	4.4	8.4	2.9	2.6	-1.0	1.0
Condit. Reinf. lever presses	6.5	9.7	14.6	3.4	3.8	-2.2	2.8
Condit. Reinf. active minus inactive responses	1.2	1.8	3.9	-1.2	-0.9	-1.0	-2.0
Condit. Reinf. active-inactive response ratio	1.7	2.8	5.4	-2.3	-1.7	-0.2	-1.6
Condit. Reinf. active responses	0.6	0.8	1.9	0.4	0.8	-1.4	-0.9
Condit. Reinf. inactive responses	2.7	4.0	8.0	2.8	2.5	-1.0	1.0
Condit. Reinf. lever presses	0.3	0.5	1.6	0.0	0.5	-1.3	-0.0
Condit. Reinf. lever reinforcers received	0.5	0.6	1.2	0.4	0.7	-1.1	-0.9
Conditioned reinforcement - actives	0.2	0.7	1.1	0.2	0.7	-1.0	1.1
Conditioned reinforcement - inactives	0.0	0.1	0.1	-0.3	-0.2	-0.2	-0.1
Conditioned locomotion	0.4	0.6	1.4	0.1	0.7	0.6	1.2
Patch foraging indifference point 0 sec	0.2	0.6	0.9	-0.8	-0.7	-0.6	-1.0
Patch foraging indifference point AUC	0.9	2.1	4.6	2.2	1.6	0.3	0.9
Delay disc. indifference point, 0s delay	1.1	1.2	3.0	1.7	0.8	-0.1	-1.0
Delay disc. indifference point, 16s delay	0.1	0.1	0.5	0.1	-0.1	0.7	0.0
Delay disc. indifference point, 2s delay	0.7	0.8	1.9	1.4	0.9	-0.5	-0.5
Delay disc. indifference point, 24s delay	0.2	0.3	0.6	0.8	0.7	0.4	0.1
Delay disc. indifference point, 4s delay	0.4	0.4	1.0	0.6	1.0	-0.5	-0.3
Delay disc. indifference point, 8s delay	2.0	3.4	5.3	2.0	2.3	-2.0	0.4
Indifference point function ln k	0.5	1.5	2.8	-1.7	-1.0	-1.0	-1.2
Indifference point function log k	0.5	1.5	2.8	-1.7	-1.0	-1.0	-1.2
Patch foraging total patch changes 0 sec	0.2	0.6	0.8	-0.9	-0.7	-0.4	-0.9
Patch foraging total patch changes 12 sec	0.3	0.3	0.6	0.8	0.1	0.8	0.5
Patch foraging total patch changes 18 sec	0.0	0.1	0.1	0.0	-0.3	0.2	0.3
Patch foraging total patch changes 24 sec	0.2	0.8	2.9	-0.1	-0.4	0.2	-1.7
Patch foraging total patch changes 6 sec	0.5	0.8	2.0	-0.3	-0.9	0.6	-1.4
Patch foraging time to switch 0 sec	0.1	0.6	1.1	-0.4	-1.1	0.9	0.3
Patch foraging water rate 0 sec	0.3	1.0	1.8	-1.0	0.2	-1.4	-1.1
Patch foraging water rate 12 sec	0.5	2.0	5.0	-1.0	-0.6	-1.3	-2.2
Patch foraging water rate 18 sec	0.8	1.7	3.1	-1.4	-1.0	0.8	-1.8
Patch foraging water rate 24 sec	1.0	1.4	3.7	-0.7	-1.1	0.3	-1.9
Patch foraging water rate 6 sec	0.7	1.0	1.9	0.1	0.4	-1.4	-1.3
Seeking ratio, delayed vs. immediate footshock	1.6	2.3	6.5	0.2	1.6	-2.6	0.3
Distance traveled before self-admin	0.5	1.1	2.3	1.1	0.7	-1.5	-0.7
Distance traveled after self-admin	0.8	1.4	4.6	-0.4	0.7	-2.2	0.5
Extensor digitorum longus weight	0.5	1.9	5.8	-0.0	1.2	-2.4	-0.5
Bone: elastic displacement	0.2	0.3	1.0	0.2	0.2	1.0	-0.1
Bone: elastic work	0.1	0.2	0.6	-0.2	0.2	0.8	-0.0
Bone: endosteal estimation	1.7	4.2	13.0	0.2	1.7	-3.6	0.9
Bone: endosteal perimeter	1.0	2.5	6.1	0.4	1.5	-2.5	1.2
Epididymis fat weight	0.4	1.8	6.8	-0.1	-0.7	2.6	-0.3
Delta time in closed arm before/after self-admin	0.6	0.5	0.8	0.8	0.5	0.9	0.6
Delta time in open arm before/after self-admin	3.5	4.1	7.1	-2.4	-2.7	0.8	-1.8
Diff in mean of infusions in LGA sessions	1.7	3.1	3.5	1.5	1.9	-1.8	1.8
Delay discount exponential model param	0.9	1.2	2.2	-1.3	-1.5	1.0	-0.0
Extinction: sum of active levers before priming	0.1	0.1	0.3	0.4	-0.0	-0.5	0.3
Active lever presses in extinction session 6	0.7	0.7	2.3	-0.1	-0.2	-1.5	-0.6
Bone: final force	0.2	0.4	0.7	-0.9	0.3	-0.5	0.6
Bone: final moment	0.3	0.4	1.2	-1.1	0.0	-0.1	0.7
Food consumed during 24 hour testing period	1.1	2.3	7.2	-1.1	0.6	-2.7	0.6
Glucose	0.6	1.0	2.2	-1.0	-1.5	0.4	-0.9
Heart weight	0.5	0.8	1.5	1.0	1.2	-0.6	-0.6
Delay discount hyperbolic model param	1.1	1.4	2.6	-1.4	-1.6	0.9	-0.1
Intermittent access intake day 1-15 change	0.2	1.2	2.3	1.1	1.2	-1.5	0.3
Intermittent access intake escalation	0.2	0.9	1.8	1.0	1.0	-1.3	0.0
Intermittent access intake escalation 2	1.4	2.4	4.7	1.6	1.6	-2.2	-0.1
Intermitt. access day 1 inactive lever presses	0.0	0.2	0.4	0.0	-0.5	0.6	0.5
Intermitt. access day 15 inactive lever presses	0.0	0.2	0.5	0.4	0.2	0.7	0.2
Intermitt. access escalation Index	0.1	0.2	0.4	-0.5	0.3	-0.6	0.2
Intermittent access day 1 total infusions	0.3	1.0	1.7	-1.3	-0.6	0.5	1.2
Intermittent access day 15 total infusions	0.1	0.4	1.2	-0.4	-0.0	-0.1	1.1
Intermittent access terminal intake (last 3 days)	0.5	0.9	2.4	-0.2	0.7	-0.8	1.5
Intermittent access total infusions	0.8	0.9	2.6	-0.9	-0.1	-0.4	1.6
Intermittent access day 1 locomotion	0.7	1.3	2.0	-1.2	-0.3	1.2	1.4
Intermittent access day 15 total locomotion	0.2	0.9	1.6	-1.3	-0.2	0.6	1.3
Intermittent access total locomotion	0.7	0.9	2.2	-1.5	-0.0	-0.3	1.1
Intermittent access standard deviation	0.3	1.6	1.9	1.3	1.4	-0.9	1.4
Left kidney weight	0.2	1.3	2.4	-0.1	1.5	-1.5	0.8
Right kidney weight	0.1	0.5	1.3	-0.3	0.9	-1.1	-0.0
Cocaine induced anxiety	0.4	1.0	1.7	1.0	1.1	-0.3	1.3
Post-drug Anxiety	0.0	0.1	0.1	0.3	0.1	0.3	0.2
Baseline Anxiety	2.2	3.7	5.8	-1.6	-2.2	1.3	-2.4
Tail length	0.2	0.9	1.9	1.3	1.4	0.2	0.2
Length with tail	0.2	1.0	2.6	1.0	1.6	-0.7	-0.1
Length without tail	0.4	2.0	5.3	-0.3	1.5	-2.3	0.2
Times rat made contact with spout	0.5	0.6	1.5	-0.6	0.6	-1.2	0.6
Lifetime Intake	0.6	0.8	2.3	-0.8	-0.2	-0.2	1.5
Liver weight, left	0.4	0.7	2.4	-1.5	-0.1	-0.6	-0.0
Liver weight, right	0.1	0.2	0.5	-0.7	0.2	-0.7	-0.0
Locomotor activity	0.3	0.4	0.7	0.1	0.8	-0.7	0.7
Locomotor testing distance	0.1	0.2	0.3	0.4	0.1	-0.6	-0.4
Locomotor testing rearing	0.0	0.2	0.5	-0.1	-0.2	-0.0	-0.7
Locomotion in novel chamber	0.1	0.2	0.4	-0.7	-0.3	0.2	0.4
Locomotion in novel chamber post-restriction	0.0	0.1	0.1	-0.3	-0.4	0.3	-0.3
Fecal boli incidents, locomotor time 1	1.4	3.6	5.5	2.3	2.1	-1.3	1.6
Change in fecal boli incidents, locomotor task	3.3	3.5	6.0	-2.5	-2.2	-0.5	-1.6
Time >=10cm from walls, locomotor time 1	0.7	0.8	1.4	0.9	0.6	-1.2	0.8
Bouts of movement, locomotor time 1	0.2	0.3	0.5	0.4	0.7	-0.3	0.5
Total resting periods, locomotor time 1	0.1	0.1	0.2	-0.0	0.3	-0.2	0.4
Rest time, locomotor task time 1	0.0	0.1	0.2	-0.5	0.0	0.1	0.2
Distance moved, locomotor task time 1	0.2	0.4	1.0	0.6	-0.4	0.5	-1.0
Vertical activity count, locomotor time 1	0.0	0.2	0.5	0.7	0.0	0.4	-0.4
Time >=10cm from walls, locomotor time 2	0.4	1.0	1.7	1.1	1.0	-0.4	1.3
Bouts of movement, locomotor time 2	0.0	0.2	0.6	0.1	-0.1	0.8	0.0
Total resting periods, locomotor time 2	0.0	0.1	0.4	-0.0	-0.3	0.6	0.0
Rest time, locomotor task time 2	0.5	0.9	1.9	-0.7	-1.4	1.1	-0.1
Distance moved, locomotor task time 2	0.4	0.5	1.8	0.4	-0.2	-0.0	-1.3
Vertical activity count, locomotor time 2	0.3	0.6	1.6	1.3	0.6	-0.6	-0.2
Light reinforcement 1	0.6	2.6	5.3	1.0	2.3	-1.9	0.8
Light reinforcement 2	0.5	1.2	4.0	-0.5	0.7	-0.3	2.0
Bone: marrow area	1.8	4.3	13.2	0.1	1.7	-3.6	1.1
Bone: maximum diameter	1.4	2.8	8.1	-0.4	1.2	-2.9	1.1
Bone: maximum force	0.3	0.6	0.8	-0.9	0.4	-0.9	0.8
Bone: maximum moment	0.3	0.5	1.0	-1.0	0.2	-0.4	0.9
Mean time between licks in bursts	0.1	0.4	1.1	1.0	0.3	0.1	0.7
Mean num. licks in bursts	0.7	1.8	5.1	-2.3	-0.9	1.2	0.0
Cd content in liver	1.2	1.3	2.9	0.6	-0.4	1.7	-1.4
Co content in liver	0.9	1.1	1.8	1.3	1.2	0.8	0.6
Cu content in liver	0.5	0.6	1.2	-0.4	1.0	-0.3	1.1
Fe content in liver	0.7	0.9	2.4	-0.4	0.3	-1.5	-1.0
K content in liver	0.0	0.0	0.1	-0.3	0.2	-0.0	-0.0
Mg content in liver	0.4	0.4	1.0	0.2	0.8	-1.0	-0.2
Mn content in liver	1.3	1.5	5.0	0.5	0.8	0.2	2.2
Na content in liver	0.8	0.8	1.9	0.3	1.0	-1.4	0.6
Rb content in liver	0.9	1.0	1.7	-1.3	-0.8	-0.2	-1.3
Se content in liver	0.9	1.0	2.1	-1.4	-1.2	0.7	-0.3
Sr content in liver	1.3	1.1	3.1	1.8	1.0	-0.2	0.7
Zn content in liver	0.3	0.3	1.0	-0.1	0.1	1.0	0.5
Bone: minimum diameter	0.5	0.9	3.1	-0.2	0.7	-0.1	1.8
Time in familiar zone, hab. session 1	1.7	1.8	2.8	1.2	1.7	-1.3	1.2
Time in novel zone, hab. session 1	2.0	2.2	3.1	-1.2	-1.8	1.3	-1.6
Total zone transitions, hab. session 1	0.7	1.0	2.9	0.6	-0.5	1.7	-0.7
Total locomotion distance, hab. session 1	1.2	1.7	3.7	0.1	-1.1	1.9	-1.4
Locomotion velocity, hab. session 1	0.5	0.7	1.7	0.2	-0.6	1.3	-0.8
Time in familiar zone, hab. session 2	0.3	0.3	0.5	0.6	0.3	-0.6	-0.7
Time in novel zone, hab. session 2	0.5	0.6	1.6	-1.3	-0.7	0.3	0.4
Total zone transitions, hab. session 2	0.8	1.1	3.0	1.7	0.9	0.6	-0.4
Total locomotion distance, hab. session 2	0.9	1.2	2.9	1.7	1.1	0.8	-0.0
Locomotion velocity, hab. session 2	1.0	1.4	2.9	1.7	1.2	1.0	0.5
Novel to familiar place preference ratio	0.4	0.5	0.8	0.2	0.9	-0.6	0.8
Novelty place preference	0.6	0.8	1.3	0.2	1.1	-0.9	1.0
Time in novel zone, NPP test	0.4	0.5	1.2	-0.3	0.8	-1.1	0.6
Total zone transitions, NPP test	0.3	0.4	0.9	0.7	0.2	0.4	-0.9
Total locomotion distance, NPP test	0.3	0.4	0.9	0.9	0.5	0.3	-0.6
Locomotion velocity, NPP test	0.5	0.6	1.8	1.3	0.6	0.5	-0.4
Intraocular pressure	0.6	0.9	1.8	-0.4	-1.1	0.7	-1.4
Delta distance traveled before/after self-admin	0.6	0.7	1.8	-1.3	0.1	-0.5	0.9
Delta ambulatory time before/after self-admin	0.4	0.6	1.3	-1.2	0.0	-0.5	0.9
Parametrial fat weight	0.7	1.7	5.3	-0.4	-0.2	2.3	1.1
Pavlov. Cond. lever latency	7.5	9.5	14.8	-3.8	-3.7	2.1	-2.2
Pavlov. Cond. magazine entry latency	11.3	14.5	26.7	5.2	4.4	-0.4	3.5
Pavlov. Cond. change in total contacts	8.0	8.7	14.1	3.8	3.6	-0.7	2.6
Pavlov. Cond. index score	10.7	13.5	23.5	4.9	4.4	-1.0	3.2
Pavlov. Cond. latency score	9.5	12.1	21.9	4.7	4.2	-1.1	2.8
Pavlov. Cond. lever contacts	9.0	10.8	17.3	4.2	4.0	-1.8	2.6
Pavlov. Cond. magazine entry number	8.2	10.5	19.6	-4.4	-3.7	0.1	-2.9
Pavlov. Cond. intertrial magazine entries	2.7	3.2	8.2	-1.3	-1.7	0.0	-2.9
Pavlov. Cond. lever-magazine prob. diff.	11.4	14.2	23.3	4.8	4.6	-1.2	3.3
Pavlov. Cond. response bias	9.7	12.0	20.5	4.5	4.2	-0.8	3.1
Pavlov. Cond. lever latency	1.2	1.7	2.9	-0.9	-1.7	1.7	-0.4
Pavlov. Cond. magazine entry latency	0.4	0.6	1.1	0.6	0.2	0.9	1.1
Pavlov. Cond. change in total contacts	0.1	0.2	0.4	0.4	0.7	-0.2	0.2
Pavlov. Cond. index score	0.4	0.7	1.0	0.9	1.0	-0.6	0.7
Pavlov. Cond. latency score	0.4	0.6	0.8	0.7	0.9	-0.9	0.7
Pavlov. Cond. lever contacts	1.2	1.8	3.1	0.9	1.7	-1.8	0.5
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	-0.1	0.0	-0.3	-0.5
Pavlov. Cond. intertrial magazine entries	0.1	0.3	0.8	0.3	0.3	-0.9	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.6	1.0	1.4	1.1	1.2	-0.6	0.9
Pavlov. Cond. response bias	0.7	1.0	2.0	1.2	1.4	-0.4	0.6
Time in closed arm before self-admin	0.6	1.1	1.2	1.0	1.1	-0.9	1.1
Time in closed arm after self-admin	0.4	0.5	0.9	0.9	0.4	0.7	0.6
Time in open arm before self-admin	0.6	0.7	1.0	0.2	1.0	-1.0	0.9
Time in open arm after self-admin	1.0	1.1	3.1	-1.8	-0.8	-0.8	-0.3
Bone: periosteal estimation	0.8	1.9	5.4	-0.8	0.8	-2.3	1.1
Bone: periosteal perimeter	0.4	0.8	1.7	-0.8	0.2	-1.3	0.8
Bone: post-yield work	1.3	2.3	5.9	0.9	1.5	-2.4	0.0
Progressive ratio test 1 active lever presses	0.6	1.1	2.0	-1.4	-0.7	0.0	1.3
Progressive ratio test 1 breakpoint	0.6	1.0	2.3	-1.3	-0.5	-0.1	1.5
Progressive ratio test 1 inactive lever presses	0.3	0.8	1.7	-1.3	-1.1	0.3	0.6
Progressive ratio test 2 active lever presses	0.5	0.7	1.3	-1.2	-0.2	-0.4	1.1
Progressive ratio test 2 breakpoint	0.5	0.6	1.2	-1.1	-0.2	-0.3	1.0
Progressive ratio test 2 inactive lever presses	0.2	0.7	1.3	-1.1	-0.7	0.1	1.0
Incentive Sensitization - Responses	0.2	0.7	1.4	-0.0	0.8	-0.8	1.2
Incentive Sensitization - Breakpoint	0.2	0.5	1.0	0.0	0.8	-0.5	1.0
Sum of active levers in priming session hrs 5-6	0.6	0.6	1.0	-0.4	-0.8	-0.8	-1.0
Progressive ratio	0.8	2.3	4.0	1.7	2.0	-0.8	1.3
Food seeking constrained by brief footshock	1.5	1.9	4.9	0.0	0.3	-2.2	-1.6
Seeking ratio, punishment vs. effort	1.0	2.2	3.8	-1.6	-1.4	-0.7	-2.0
Retroperitoneal fat weight	0.9	4.0	12.9	-0.9	-1.5	3.6	-0.4
Reaction time number correct	0.1	0.3	0.8	-0.0	-0.5	-0.4	-0.9
Reaction time mean minus median	0.2	1.0	1.8	-1.3	-0.6	1.3	0.3
Reaction time mean minus median AUC	0.1	0.8	1.5	-1.2	-0.7	1.1	0.1
Reaction time num false alarms	0.8	1.4	2.2	-1.0	-1.5	1.2	-1.1
Reaction time num false alarms AUC	0.6	1.4	2.2	-1.1	-1.5	0.9	-1.3
Reaction time trials correct on left	0.1	0.3	0.8	-0.0	-0.5	-0.4	-0.9
Reaction time trials on left	0.1	0.4	1.0	-0.1	-0.6	-0.3	-1.0
Reaction time mean	0.4	1.0	2.0	-0.9	-0.6	1.4	1.0
Reaction time mean AUC	0.4	0.9	1.4	-1.1	-0.6	1.2	0.8
Median of all reaction times	0.6	0.9	1.9	-0.6	-0.6	1.4	1.1
Reaction time omissions	1.4	2.2	3.7	-0.9	-1.9	1.9	-1.0
Reaction time false alarm rate	0.6	0.9	1.3	-0.7	-1.1	1.1	-0.7
Reaction time premature initiation rate	0.0	0.1	0.1	0.2	0.3	0.1	-0.3
Reaction time premature initiations	0.1	0.2	0.6	0.2	0.1	-0.1	-0.8
Std. dev. reaction times	0.3	1.1	2.8	-1.0	-0.8	1.7	0.3
Reaction time trials completed	0.1	0.4	1.0	-0.1	-0.6	-0.3	-1.0
Reaction time trials AUC	0.1	0.4	1.0	-0.1	-0.7	-0.4	-1.0
Run reversals in cocaine runway, females	0.8	0.9	1.8	-1.0	-1.4	0.8	-0.4
Run reversals in cocaine runway, males	0.3	0.3	0.7	-0.1	0.2	-0.7	-0.8
Latency to leave start box in cocaine runway	0.3	0.4	0.9	0.3	0.8	-0.9	0.4
Latency to leave start box in cocaine runway, F	0.0	0.1	0.2	-0.0	0.2	-0.5	-0.1
Latency to leave start box in cocaine runway, M	0.5	0.5	0.8	0.2	0.9	-0.8	0.6
Std. dev. time between licks in bursts	1.7	3.2	5.7	2.4	2.0	-1.6	0.8
Total sessions with >9 infusions	0.3	0.4	1.3	-0.3	-0.3	-0.2	1.1
Short access day 1 total inactive lever presses	0.3	0.5	1.7	0.5	0.4	0.2	1.3
Short access day 10 total inactive lever presses	0.1	0.7	2.1	1.4	0.9	0.1	0.2
Short access day 1 total infusions	0.4	0.8	1.8	0.9	0.5	-0.4	1.3
Short access day 10 total infusions	0.8	1.4	2.2	-1.4	-1.0	0.4	1.5
Short access total infusions	0.5	0.7	1.5	-0.9	-0.8	0.3	1.2
Short access day 1 locomotion	0.7	1.2	2.3	1.5	1.1	-0.1	1.0
Short access day 10 total locomotion	0.1	0.2	0.9	-0.1	0.1	-0.3	0.9
Short access total locomotion	0.7	1.0	3.5	0.6	0.6	-0.1	1.9
One hour access (0.3 mA shock)	0.9	1.1	3.5	-1.9	-0.5	0.1	0.8
Compulsive drug intake	0.7	1.1	2.4	-1.5	-1.2	-0.3	-0.6
One hour access (shock baseline)	0.3	0.8	2.6	0.0	0.8	0.0	1.6
Social response proportion	0.7	0.8	2.2	-1.5	-0.7	0.7	0.5
Social responses	0.6	0.8	1.6	0.8	0.9	-0.3	1.3
Social time	0.1	0.2	0.6	-0.8	-0.3	-0.2	-0.1
Soleus weight	3.2	9.4	29.0	0.5	2.9	-5.4	-0.0
Bone: stiffness	0.6	1.1	2.2	-1.5	-1.1	-0.2	-0.9
Tibialis anterior weight	1.8	6.2	21.2	-1.1	0.3	-4.6	-1.5
Time to tail flick, vehicle, before self-admin	1.0	1.2	2.2	-1.5	-1.3	0.5	-0.8
Time to tail flick, vehicle, after self-admin	0.2	0.3	1.2	-0.2	-0.1	-1.1	0.4
Time to tail flick, test, before self-admin	0.7	0.8	1.5	0.9	0.7	1.2	0.4
Time to tail flick, test, after self-admin	2.7	2.9	7.9	2.8	1.6	-0.9	0.3
Delta time to tail flick, vehicle, before/after SA	1.1	1.2	2.3	1.2	1.0	-1.5	0.2
Delta time to tail flick, test, before/after SA	0.9	1.1	3.4	0.7	0.6	-1.8	0.2
Tibia length	1.5	4.2	9.0	-0.5	2.0	-1.9	3.0
Ambulatory time before self-admin	0.2	0.7	1.2	1.1	0.7	-1.0	-0.2
Ambulatory time after self-admin	0.7	1.1	3.5	-0.2	0.7	-1.9	0.7
Bone: tissue strength	2.1	2.2	3.9	-2.0	-1.6	1.3	-0.8
Total heroin consumption	0.5	0.6	2.2	-0.1	0.3	-1.5	-0.5
Bone: trabecular number	0.6	1.2	3.5	1.9	1.0	0.0	0.7
Bone: trabecular spacing	0.9	1.3	3.4	-0.8	-1.0	1.8	-0.4
Bone: trabecular thickness	0.1	0.1	0.2	0.2	-0.0	0.2	0.4
Bone: trabecular tissue density	1.2	2.1	6.0	-2.4	-1.5	0.4	-0.0
Water consumed over 24 hours	0.7	1.3	3.4	0.1	1.1	-1.9	0.8
Number of responses in last shaping day	3.2	4.2	5.7	2.1	2.4	-1.6	2.1