Hub : Genes

Olfr94-ps1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Olfr94-ps1	0.83	0.18	0.0e+00	0.43	0.43	0.45	0.45	2.4e-52	3.9e-52	2.0e-55	7.6e-55
2	Brain	gene expression	Olfr94-ps1	0.03	0.02	6.6e-03	0.01	0.02	0.01	0.01	5.8e-02	9.2e-03	2.5e-02	2.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bone: apparent density	1.1	2.0	2.1	1.4	-1.4
Area under the delay curve	2.4	2.8	3.1	-1.8	1.5
BMI with tail	1.1	3.9	6.1	-1.3	2.5
BMI without tail	2.5	7.7	9.1	-2.5	3.0
Body weight	5.1	22.1	25.2	-5.0	4.4
Weight adjusted by age	1.2	1.8	2.8	-1.7	0.9
Bone surface	0.2	0.4	0.6	-0.7	-0.4
Bone volume	0.1	0.1	0.1	-0.4	-0.4
Breakpoint value in progressive ratio session	0.8	0.9	1.8	1.3	-0.2
Number of licking bursts	0.0	0.1	0.2	-0.4	0.0
Context. condit. distance diff. score	4.9	5.9	8.4	1.8	-2.9
Locomotion velocity, session 1	0.1	0.1	0.2	0.1	-0.5
Locomotion distance, session 1	0.8	1.0	1.6	1.3	-0.6
Locomotion velocity, session 2	0.2	0.2	0.4	-0.1	0.6
Locomotion distance, session 2	0.7	1.0	1.0	1.0	-0.9
Locomotion velocity, session 3	0.3	0.3	0.6	0.2	0.8
Locomotion distance, session 3	1.2	1.3	1.4	1.2	-1.1
Stereotopy head waving bouts, day 3	0.7	0.8	1.2	-1.1	0.7
Stereotopy head waving duration, day 3	0.7	0.9	1.0	-1.0	0.8
Locomotion velocity, session 7	3.0	3.2	3.8	1.6	-1.9
Locomotion distance, session 7	2.8	3.5	3.6	1.8	-1.9
Stereotopy head waving bouts, day 7	2.4	2.7	3.4	-1.8	1.4
Stereotopy head waving duration, day 7	2.5	3.0	3.7	-1.9	1.5
Locomotion velocity, session 8	0.4	0.5	0.6	-0.8	-0.6
Locomotion distance, session 8	3.3	4.8	6.9	1.6	-2.6
Degree of sensitization distance	0.1	0.1	0.2	-0.1	-0.5
Degree of sensitization stereotypy	1.1	1.2	1.5	-1.2	1.0
Conditioned locomotion	2.6	3.0	3.5	-1.6	1.9
Cocaine response after cond. corrected	0.4	0.5	0.9	0.9	0.3
Cocaine response after cond. not corrected	0.3	0.4	0.6	-0.4	0.8
Cocaine response before conditioning	4.8	5.8	9.5	-3.1	1.4
Saline control response	1.2	1.6	1.9	-1.2	1.4
Bone: connectivity density	2.2	3.5	4.5	1.6	-2.1
Bone: cortical apparent density	0.4	0.6	1.1	-0.2	1.0
Bone: cortical area	0.6	0.9	1.5	-1.2	0.5
Bone: cortical porosity	0.1	0.1	0.1	-0.4	0.3
Bone: cortical porosity	0.2	0.2	0.4	-0.6	0.0
Bone: cortical thickness	0.9	1.5	2.4	-0.8	1.6
Bone: cortical thickness	0.4	0.5	0.9	0.3	1.0
Bone: cortical tissue density	0.4	0.5	1.0	-0.2	1.0
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	0.5	-0.2
Condit. Reinf. active-inactive response ratio	0.5	0.5	1.0	-0.2	1.0
Condit. Reinf. active responses	0.7	0.9	1.3	1.1	-0.7
Condit. Reinf. inactive responses	2.7	3.3	4.4	2.1	-1.5
Incentive salience index mean	0.6	0.7	0.7	0.8	-0.8
Condit. Reinf. lever presses	2.5	3.5	3.6	1.9	-1.9
Condit. Reinf. active minus inactive responses	0.5	0.6	0.9	-0.9	0.6
Condit. Reinf. active-inactive response ratio	1.8	2.0	2.5	-1.6	1.2
Condit. Reinf. active responses	0.2	0.3	0.4	0.4	-0.6
Condit. Reinf. inactive responses	1.4	1.8	1.8	1.3	-1.4
Condit. Reinf. lever presses	2.2	3.0	3.8	1.5	-2.0
Condit. Reinf. lever reinforcers received	0.4	0.6	0.8	0.6	-0.9
Conditioned reinforcement - actives	0.5	0.9	0.9	-0.9	1.0
Conditioned reinforcement - inactives	0.2	0.4	0.4	-0.5	0.6
Conditioned locomotion	0.3	0.5	0.8	-0.9	0.4
Patch foraging indifference point 0 sec	0.1	0.1	0.2	-0.1	-0.4
Patch foraging indifference point AUC	1.0	1.4	2.0	-1.4	0.9
Delay disc. indifference point, 0s delay	1.0	1.1	1.1	-1.1	1.1
Delay disc. indifference point, 16s delay	1.3	1.5	1.9	-1.0	1.4
Delay disc. indifference point, 2s delay	2.4	2.6	2.9	-1.7	1.5
Delay disc. indifference point, 24s delay	0.8	0.9	1.1	-1.1	0.9
Delay disc. indifference point, 4s delay	4.1	4.3	5.0	-2.2	1.9
Delay disc. indifference point, 8s delay	0.5	0.6	1.0	-1.0	0.3
Indifference point function ln k	0.4	0.6	1.0	0.6	-1.0
Indifference point function log k	0.4	0.6	1.0	0.6	-1.0
Patch foraging total patch changes 0 sec	0.0	0.1	0.1	-0.3	-0.3
Patch foraging total patch changes 12 sec	0.0	0.0	0.0	-0.2	0.1
Patch foraging total patch changes 18 sec	0.2	0.3	0.3	0.6	-0.4
Patch foraging total patch changes 24 sec	0.2	0.3	0.4	0.6	-0.4
Patch foraging total patch changes 6 sec	0.3	0.4	0.5	-0.6	0.7
Patch foraging time to switch 0 sec	0.2	0.4	0.5	0.6	0.7
Patch foraging water rate 0 sec	0.1	0.3	0.3	-0.6	-0.5
Patch foraging water rate 12 sec	0.0	0.0	0.1	0.2	-0.1
Patch foraging water rate 18 sec	0.0	0.0	0.0	-0.1	-0.1
Patch foraging water rate 24 sec	0.4	0.5	0.8	-0.9	0.5
Patch foraging water rate 6 sec	0.0	0.0	0.1	0.2	-0.2
Seeking ratio, delayed vs. immediate footshock	0.6	0.7	0.8	-0.8	0.9
Distance traveled before self-admin	0.2	0.3	0.6	-0.1	-0.8
Distance traveled after self-admin	0.2	0.3	0.5	-0.7	0.3
Extensor digitorum longus weight	0.2	0.8	1.4	-0.5	-1.2
Bone: elastic displacement	0.6	0.7	0.7	-0.8	0.9
Bone: elastic work	1.1	1.4	1.5	-1.2	1.2
Bone: endosteal estimation	1.9	4.2	7.9	-2.8	0.7
Bone: endosteal perimeter	0.6	1.4	1.6	-1.1	-1.3
Epididymis fat weight	1.1	3.9	7.8	0.1	2.8
Delta time in closed arm before/after self-admin	0.4	0.3	0.4	-0.5	0.7
Delta time in open arm before/after self-admin	0.2	0.2	0.2	-0.4	-0.4
Diff in mean of infusions in LGA sessions	3.5	4.2	6.6	2.6	-1.4
Delay discount exponential model param	2.6	2.9	3.3	1.8	-1.6
Extinction: sum of active levers before priming	1.3	1.5	2.5	1.6	-0.6
Active lever presses in extinction session 6	0.9	0.8	1.2	1.1	0.7
Bone: final force	1.8	2.9	3.4	-1.5	1.8
Bone: final moment	1.3	2.1	2.1	-1.5	1.4
Food consumed during 24 hour testing period	0.6	0.8	1.3	-1.2	0.5
Glucose	1.6	2.5	4.9	-0.0	-2.2
Heart weight	2.5	3.9	4.9	-2.2	1.7
Delay discount hyperbolic model param	2.6	2.9	3.1	1.8	-1.6
Intermittent access intake day 1-15 change	0.0	0.0	0.0	-0.1	0.1
Intermittent access intake escalation	0.2	0.4	0.6	-0.5	0.8
Intermittent access intake escalation 2	0.1	0.2	0.2	-0.4	-0.4
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.1	-0.2	-0.3
Intermitt. access day 15 inactive lever presses	0.4	0.8	1.3	-1.1	0.5
Intermitt. access escalation Index	1.6	2.3	3.8	1.9	-0.9
Intermittent access day 1 total infusions	0.1	0.2	0.3	0.5	0.3
Intermittent access day 15 total infusions	0.6	0.8	1.6	-0.3	1.3
Intermittent access terminal intake (last 3 days)	0.6	0.8	1.3	-0.6	1.2
Intermittent access total infusions	0.5	0.5	0.9	-0.4	1.0
Intermittent access day 1 locomotion	0.3	0.4	0.7	-0.3	0.8
Intermittent access day 15 total locomotion	2.1	3.8	3.8	-1.9	1.9
Intermittent access total locomotion	2.6	3.2	3.5	-1.7	1.9
Intermittent access standard deviation	0.6	1.2	1.7	-1.3	0.8
Left kidney weight	3.0	13.7	17.7	-4.2	3.1
Right kidney weight	4.0	18.1	23.0	-4.8	3.6
Cocaine induced anxiety	0.5	0.7	1.2	0.3	-1.1
Post-drug Anxiety	0.7	0.7	0.9	0.8	-0.9
Baseline Anxiety	0.6	0.7	1.4	1.2	-0.1
Tail length	3.0	11.8	19.2	-4.4	2.1
Length with tail	3.8	16.7	27.9	-5.3	2.3
Length without tail	3.5	11.2	14.9	-3.9	2.7
Times rat made contact with spout	1.4	1.6	2.7	1.6	-0.7
Lifetime Intake	0.6	0.8	1.2	-0.6	1.1
Liver weight, left	0.4	0.7	1.4	-1.2	-0.1
Liver weight, right	2.8	4.9	8.2	-2.9	1.3
Locomotor activity	0.9	1.4	2.4	-1.6	-0.6
Locomotor testing distance	0.5	0.9	1.0	-0.9	-1.0
Locomotor testing rearing	0.3	0.7	1.2	-1.1	-0.4
Locomotion in novel chamber	0.0	0.0	0.0	-0.1	0.1
Locomotion in novel chamber post-restriction	0.6	1.0	1.1	-1.0	1.0
Fecal boli incidents, locomotor time 1	0.8	1.1	1.3	1.1	-1.0
Change in fecal boli incidents, locomotor task	1.8	1.8	2.4	-1.1	1.5
Time >=10cm from walls, locomotor time 1	0.8	0.9	1.3	-1.1	0.7
Bouts of movement, locomotor time 1	0.8	0.9	1.7	0.4	-1.3
Total resting periods, locomotor time 1	0.3	0.3	0.6	0.1	-0.8
Rest time, locomotor task time 1	0.4	0.4	0.6	-0.8	0.5
Distance moved, locomotor task time 1	0.0	0.0	0.0	-0.1	-0.0
Vertical activity count, locomotor time 1	0.0	0.0	0.0	-0.2	-0.2
Time >=10cm from walls, locomotor time 2	0.4	0.6	1.1	-1.1	0.4
Bouts of movement, locomotor time 2	0.3	0.5	1.0	-1.0	0.1
Total resting periods, locomotor time 2	0.2	0.4	0.7	-0.8	-0.2
Rest time, locomotor task time 2	0.2	0.3	0.5	-0.1	-0.7
Distance moved, locomotor task time 2	0.4	0.5	0.6	-0.5	0.8
Vertical activity count, locomotor time 2	0.0	0.0	0.0	-0.1	0.0
Light reinforcement 1	0.0	0.1	0.1	-0.1	0.4
Light reinforcement 2	1.9	3.0	3.8	-1.9	1.5
Bone: marrow area	1.9	4.1	7.7	-2.8	0.7
Bone: maximum diameter	0.4	0.8	0.9	-0.9	-0.9
Bone: maximum force	1.4	2.5	2.7	-1.7	1.5
Bone: maximum moment	1.1	1.9	2.6	-1.6	1.1
Mean time between licks in bursts	0.2	0.4	0.6	-0.4	-0.7
Mean num. licks in bursts	0.5	0.8	1.4	1.2	-0.4
Cd content in liver	0.0	0.0	0.1	0.2	-0.1
Co content in liver	0.3	0.4	0.7	-0.1	0.8
Cu content in liver	0.9	1.1	1.7	1.3	-0.8
Fe content in liver	1.1	1.3	2.4	-0.4	1.6
K content in liver	0.5	0.4	0.5	0.7	-0.6
Mg content in liver	0.7	0.7	1.2	0.5	-1.1
Mn content in liver	1.5	1.7	3.0	0.6	-1.7
Na content in liver	0.1	0.1	0.2	-0.2	0.4
Rb content in liver	0.6	0.7	0.9	0.7	-1.0
Se content in liver	0.2	0.2	0.3	-0.6	-0.3
Sr content in liver	0.4	0.3	0.5	-0.7	0.5
Zn content in liver	0.5	0.5	0.9	0.4	-1.0
Bone: minimum diameter	0.4	0.8	1.2	-1.1	-0.5
Time in familiar zone, hab. session 1	1.5	1.5	2.3	1.5	-0.7
Time in novel zone, hab. session 1	1.1	1.1	2.2	-1.5	0.0
Total zone transitions, hab. session 1	0.7	1.0	1.2	0.9	-1.1
Total locomotion distance, hab. session 1	0.4	0.6	0.6	0.8	-0.8
Locomotion velocity, hab. session 1	0.2	0.3	0.5	0.7	-0.4
Time in familiar zone, hab. session 2	0.8	0.9	1.5	1.2	-0.5
Time in novel zone, hab. session 2	1.0	1.0	1.4	-1.2	0.7
Total zone transitions, hab. session 2	0.0	0.0	0.1	0.2	0.1
Total locomotion distance, hab. session 2	0.6	0.8	1.1	1.0	-0.8
Locomotion velocity, hab. session 2	0.8	1.1	1.2	1.1	-0.9
Novel to familiar place preference ratio	0.2	0.2	0.2	-0.5	0.5
Novelty place preference	0.5	0.5	0.5	-0.7	0.7
Time in novel zone, NPP test	0.7	0.8	0.9	-1.0	0.8
Total zone transitions, NPP test	0.8	1.2	1.8	0.8	-1.3
Total locomotion distance, NPP test	0.5	0.7	0.8	0.8	-0.9
Locomotion velocity, NPP test	1.2	1.7	1.9	1.4	-1.3
Intraocular pressure	0.7	1.0	1.2	1.0	-1.1
Delta distance traveled before/after self-admin	2.1	2.2	2.5	-1.4	1.6
Delta ambulatory time before/after self-admin	1.3	1.6	1.8	-1.2	1.3
Parametrial fat weight	0.7	1.6	1.9	-1.2	1.4
Pavlov. Cond. lever latency	0.2	0.3	0.5	0.1	0.7
Pavlov. Cond. magazine entry latency	1.1	1.4	1.7	1.1	-1.3
Pavlov. Cond. change in total contacts	0.7	0.7	1.1	-1.0	0.6
Pavlov. Cond. index score	0.6	0.7	1.1	0.6	-1.1
Pavlov. Cond. latency score	0.4	0.5	0.8	0.4	-0.9
Pavlov. Cond. lever contacts	0.2	0.2	0.4	-0.2	-0.6
Pavlov. Cond. magazine entry number	1.3	1.7	1.8	-1.3	1.3
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.6	0.8	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	1.4	0.8	-1.2
Pavlov. Cond. response bias	0.7	0.8	1.1	0.8	-1.0
Pavlov. Cond. lever latency	0.7	1.0	1.0	-1.0	1.0
Pavlov. Cond. magazine entry latency	0.2	0.2	0.3	-0.6	0.3
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	-0.2	0.2
Pavlov. Cond. index score	0.0	0.1	0.1	0.1	-0.3
Pavlov. Cond. latency score	0.0	0.0	0.0	0.1	-0.2
Pavlov. Cond. lever contacts	0.4	0.6	0.6	0.7	-0.8
Pavlov. Cond. magazine entry number	0.2	0.3	0.4	0.6	-0.4
Pavlov. Cond. intertrial magazine entries	0.5	0.7	1.0	0.6	-1.0
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	0.2	-0.4
Pavlov. Cond. response bias	0.2	0.3	0.5	0.3	-0.7
Time in closed arm before self-admin	0.0	0.0	0.0	0.1	0.1
Time in closed arm after self-admin	1.6	1.8	2.7	-0.9	1.7
Time in open arm before self-admin	0.3	0.3	0.4	0.6	-0.5
Time in open arm after self-admin	1.0	1.1	1.8	0.6	-1.4
Bone: periosteal estimation	1.6	3.4	6.2	-2.5	0.8
Bone: periosteal perimeter	0.7	1.1	2.3	-1.5	-0.1
Bone: post-yield work	1.0	1.4	2.8	0.0	-1.7
Progressive ratio test 1 active lever presses	0.5	0.6	1.2	-0.0	1.1
Progressive ratio test 1 breakpoint	0.5	0.6	1.2	-0.1	1.1
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.2	0.4	0.3
Progressive ratio test 2 active lever presses	0.4	0.5	0.5	0.7	0.7
Progressive ratio test 2 breakpoint	0.5	0.5	0.6	0.7	0.8
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.3	-0.3	0.6
Incentive Sensitization - Responses	0.7	1.0	1.9	1.4	-0.2
Incentive Sensitization - Breakpoint	0.8	1.0	2.0	1.4	-0.1
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.5	0.7	-0.4
Progressive ratio	4.0	6.3	8.1	-2.1	2.8
Food seeking constrained by brief footshock	0.0	0.1	0.1	0.3	-0.2
Seeking ratio, punishment vs. effort	3.4	4.9	6.2	1.9	-2.5
Retroperitoneal fat weight	0.5	2.0	2.1	-1.5	1.4
Reaction time number correct	0.3	0.5	1.0	-0.2	1.0
Reaction time mean minus median	0.3	0.7	1.1	-0.6	-1.0
Reaction time mean minus median AUC	0.3	0.7	1.0	-0.6	-1.0
Reaction time num false alarms	0.1	0.2	0.3	-0.5	0.1
Reaction time num false alarms AUC	0.1	0.1	0.3	-0.5	0.0
Reaction time trials correct on left	0.3	0.5	1.0	-0.2	1.0
Reaction time trials on left	0.3	0.5	1.0	-0.3	1.0
Reaction time mean	1.0	1.5	3.0	-0.2	-1.7
Reaction time mean AUC	0.8	1.3	2.6	-0.3	-1.6
Median of all reaction times	0.9	1.3	2.6	-0.0	-1.6
Reaction time omissions	0.1	0.2	0.2	-0.3	-0.5
Reaction time false alarm rate	0.2	0.3	0.4	-0.3	-0.6
Reaction time premature initiation rate	0.6	0.8	1.0	-0.8	1.0
Reaction time premature initiations	1.0	1.9	2.8	-1.0	1.7
Std. dev. reaction times	0.4	0.8	1.1	-0.7	-1.1
Reaction time trials completed	0.3	0.5	1.0	-0.3	1.0
Reaction time trials AUC	0.3	0.5	0.9	-0.2	1.0
Run reversals in cocaine runway, females	0.5	0.5	0.6	0.8	-0.7
Run reversals in cocaine runway, males	1.5	1.5	2.9	-1.7	0.3
Latency to leave start box in cocaine runway	0.1	0.1	0.2	-0.1	0.4
Latency to leave start box in cocaine runway, F	0.4	0.4	0.5	0.6	-0.7
Latency to leave start box in cocaine runway, M	2.6	2.4	3.5	-1.2	1.9
Std. dev. time between licks in bursts	0.2	0.3	0.3	-0.4	-0.6
Total sessions with >9 infusions	0.6	0.7	1.2	-0.5	1.1
Short access day 1 total inactive lever presses	0.6	0.8	1.3	-1.1	0.6
Short access day 10 total inactive lever presses	0.9	2.3	2.6	1.4	-1.6
Short access day 1 total infusions	0.0	0.0	0.0	0.1	-0.0
Short access day 10 total infusions	0.3	0.4	0.8	-0.3	0.9
Short access total infusions	0.5	0.6	0.9	-0.6	0.9
Short access day 1 locomotion	0.5	0.6	0.8	0.9	-0.7
Short access day 10 total locomotion	0.3	0.6	1.0	-1.0	0.4
Short access total locomotion	0.2	0.2	0.2	-0.5	0.5
One hour access (0.3 mA shock)	1.3	1.5	1.8	1.3	-1.1
Compulsive drug intake	3.2	3.8	4.1	2.0	-1.9
One hour access (shock baseline)	0.2	0.4	0.4	-0.7	0.6
Social response proportion	0.1	0.2	0.3	-0.1	-0.6
Social responses	0.1	0.1	0.2	-0.4	0.2
Social time	0.2	0.2	0.4	0.1	-0.7
Soleus weight	0.4	1.1	1.4	-0.9	-1.2
Bone: stiffness	0.1	0.2	0.5	-0.1	0.7
Tibialis anterior weight	0.0	0.1	0.1	0.3	0.3
Time to tail flick, vehicle, before self-admin	0.6	0.6	0.9	0.9	-0.6
Time to tail flick, vehicle, after self-admin	0.6	0.8	0.9	1.0	-0.8
Time to tail flick, test, before self-admin	0.1	0.1	0.2	0.4	0.1
Time to tail flick, test, after self-admin	0.2	0.2	0.2	0.5	-0.4
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.0	0.1	0.0
Delta time to tail flick, test, before/after SA	0.3	0.3	0.4	0.7	-0.4
Tibia length	1.6	4.5	6.8	-2.6	1.5
Ambulatory time before self-admin	0.1	0.2	0.3	0.0	-0.5
Ambulatory time after self-admin	0.3	0.3	0.4	-0.6	0.5
Bone: tissue strength	0.4	0.4	0.5	-0.6	0.7
Total heroin consumption	0.2	0.3	0.3	0.5	-0.5
Bone: trabecular number	0.6	1.0	1.2	1.1	-0.9
Bone: trabecular spacing	2.7	3.6	4.1	-2.0	1.8
Bone: trabecular thickness	1.3	1.6	1.7	1.3	-1.2
Bone: trabecular tissue density	0.9	1.3	1.6	-1.3	1.0
Water consumed over 24 hours	0.0	0.0	0.0	-0.2	0.2
Number of responses in last shaping day	0.8	0.8	1.6	-1.3	0.3