Olfml2b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Olfml2b	0.4	0.24	2.7e-04	0.03	0.04	0.04	0.03	5.0e-04	8.1e-05	1.8e-05	1.7e-04
2	Liver	gene expression	Olfml2b	0.21	0.2	1.8e-12	0.09	0.09	0.12	0.12	6.3e-10	1.4e-10	9.2e-13	4.3e-13
3	NAcc	gene expression	Olfml2b	0.03	0.02	1.1e-04	0.02	0.03	0.02	0.02	9.7e-04	5.9e-05	6.6e-04	3.6e-04
4	pVTA	gene expression	Olfml2b	0.04	0.04	2.4e-04	0.04	0.04	0.04	0.04	6.6e-04	1.5e-04	5.2e-04	4.6e-04
5	Brain	gene expression	Olfml2b	0.07	0.07	2.7e-06	0.05	0.06	0.05	0.05	2.7e-05	7.2e-06	3.2e-05	3.8e-05
6	RMTg	gene expression	Olfml2b	0.15	0.13	8.1e-03	0.03	0.04	0.03	0.03	4.6e-02	3.2e-02	6.9e-02	7.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.2	0.3	0.4	-0.4	-0.4	0.6	0.6	0.6	0.6
Area under the delay curve	6.4	9.8	18.0	-4.2	-2.5	2.9	2.9	2.9	2.9
BMI with tail	1.2	4.2	16.9	-4.1	1.3	-1.3	-1.3	-1.3	-1.3
BMI without tail	0.4	1.9	11.6	-3.4	0.0	0.1	0.1	0.0	0.0
Body weight	1.1	4.6	15.3	-3.9	1.6	-1.6	-1.6	-1.6	-1.6
Weight adjusted by age	0.2	0.7	0.9	0.2	-0.8	0.9	1.0	1.0	1.0
Bone surface	0.9	1.7	2.0	-0.9	-1.2	1.4	1.4	1.4	1.4
Bone volume	0.0	0.0	0.1	-0.1	-0.0	0.2	0.2	0.2	0.2
Breakpoint value in progressive ratio session	0.7	1.2	2.2	1.5	-1.1	1.0	1.0	1.0	1.0
Number of licking bursts	0.0	0.0	0.1	-0.4	-0.0	-0.1	-0.1	-0.1	-0.1
Context. condit. distance diff. score	2.1	2.5	3.0	-0.9	-1.4	1.7	1.7	1.7	1.7
Locomotion velocity, session 1	1.3	1.4	1.8	0.1	-1.3	1.3	1.3	1.3	1.3
Locomotion distance, session 1	0.0	0.1	0.2	0.5	-0.4	-0.1	-0.0	-0.1	-0.1
Locomotion velocity, session 2	0.3	0.4	1.7	1.3	-0.3	0.4	0.4	0.4	0.4
Locomotion distance, session 2	0.4	0.5	2.2	1.5	0.0	-0.4	-0.4	-0.4	-0.5
Locomotion velocity, session 3	0.4	0.5	0.8	0.9	-0.7	0.6	0.7	0.6	0.6
Locomotion distance, session 3	0.2	0.2	0.2	0.2	0.4	-0.5	-0.5	-0.5	-0.5
Stereotopy head waving bouts, day 3	0.9	1.0	5.4	-2.3	-0.3	0.4	0.4	0.4	0.4
Stereotopy head waving duration, day 3	1.1	1.4	3.1	-1.8	-0.8	1.1	1.0	1.1	1.1
Locomotion velocity, session 7	0.2	0.2	0.5	-0.7	-0.1	0.3	0.3	0.4	0.4
Locomotion distance, session 7	0.3	0.4	2.4	-1.6	0.3	0.1	0.1	0.1	0.1
Stereotopy head waving bouts, day 7	1.2	1.4	1.8	0.6	-1.0	1.3	1.3	1.3	1.3
Stereotopy head waving duration, day 7	2.2	2.7	3.3	0.9	-1.4	1.8	1.8	1.8	1.8
Locomotion velocity, session 8	0.8	1.0	1.1	1.1	-1.1	1.0	1.0	1.0	0.9
Locomotion distance, session 8	0.2	0.3	0.4	0.1	-0.6	0.7	0.7	0.6	0.6
Degree of sensitization distance	1.1	1.2	2.0	-1.4	-0.8	1.0	1.0	1.0	1.1
Degree of sensitization stereotypy	1.3	1.4	4.2	2.0	-0.8	1.0	1.0	1.0	0.9
Conditioned locomotion	0.3	0.4	1.9	-1.4	-0.3	0.2	0.2	0.2	0.3
Cocaine response after cond. corrected	2.1	3.1	3.6	-1.1	1.9	-1.9	-1.9	-1.9	-1.9
Cocaine response after cond. not corrected	1.2	1.8	2.2	-0.2	1.4	-1.5	-1.5	-1.5	-1.5
Cocaine response before conditioning	1.8	2.2	2.7	1.3	-1.6	1.5	1.5	1.5	1.5
Saline control response	0.2	0.3	1.7	-1.3	0.5	0.1	0.1	0.1	0.1
Bone: connectivity density	1.5	2.4	2.8	-0.7	-1.7	1.7	1.7	1.7	1.6
Bone: cortical apparent density	2.1	3.2	3.8	1.0	1.8	-1.9	-1.9	-1.9	-1.9
Bone: cortical area	0.3	0.4	0.8	0.9	0.4	-0.6	-0.6	-0.6	-0.6
Bone: cortical porosity	1.0	1.1	2.9	1.7	-0.9	0.8	0.9	0.8	0.8
Bone: cortical porosity	1.1	1.2	1.7	-0.0	-1.3	1.2	1.2	1.2	1.2
Bone: cortical thickness	0.6	1.0	4.6	2.2	0.2	-0.6	-0.6	-0.6	-0.6
Bone: cortical thickness	1.5	1.9	7.0	2.7	0.9	-0.9	-0.9	-0.9	-1.0
Bone: cortical tissue density	2.0	3.1	3.7	0.9	1.8	-1.9	-1.9	-1.9	-1.9
Condit. Reinf. active minus inactive responses	0.5	0.6	0.7	-0.8	-0.8	0.7	0.7	0.7	0.7
Condit. Reinf. active-inactive response ratio	1.6	1.7	2.4	-0.8	-1.6	1.4	1.3	1.3	1.4
Condit. Reinf. active responses	0.2	0.3	1.8	-1.3	-0.2	0.2	0.1	0.1	0.1
Condit. Reinf. inactive responses	1.7	2.2	2.9	-0.5	1.7	-1.6	-1.6	-1.6	-1.6
Incentive salience index mean	0.0	0.0	0.0	-0.0	0.1	-0.1	-0.1	-0.2	-0.2
Condit. Reinf. lever presses	0.4	0.6	1.3	1.1	0.6	-0.7	-0.7	-0.7	-0.7
Condit. Reinf. active minus inactive responses	0.2	0.4	1.7	-1.3	-0.1	0.3	0.3	0.4	0.4
Condit. Reinf. active-inactive response ratio	0.7	1.1	3.9	-2.0	1.0	-0.6	-0.7	-0.6	-0.6
Condit. Reinf. active responses	0.5	0.7	0.7	-0.9	-0.7	0.8	0.8	0.8	0.8
Condit. Reinf. inactive responses	1.9	2.8	3.2	1.2	-1.7	1.8	1.8	1.8	1.7
Condit. Reinf. lever presses	0.7	1.0	1.8	0.7	1.3	-0.9	-0.9	-0.9	-0.9
Condit. Reinf. lever reinforcers received	0.3	0.4	0.6	-0.8	-0.5	0.7	0.7	0.7	0.7
Conditioned reinforcement - actives	0.5	2.1	12.6	3.6	0.0	0.1	0.1	0.1	0.1
Conditioned reinforcement - inactives	0.5	1.3	7.7	2.8	-0.1	0.1	0.1	0.1	0.2
Conditioned locomotion	2.2	3.3	18.5	4.3	-0.6	0.4	0.4	0.4	0.4
Patch foraging indifference point 0 sec	1.0	2.9	3.7	1.9	1.8	-1.6	-1.6	-1.6	-1.6
Patch foraging indifference point AUC	0.7	1.7	2.9	0.1	-1.7	1.4	1.4	1.4	1.4
Delay disc. indifference point, 0s delay	5.2	5.9	13.1	-3.6	-2.2	2.1	2.1	2.1	2.1
Delay disc. indifference point, 16s delay	2.0	2.9	9.0	-3.0	-0.9	1.4	1.4	1.4	1.4
Delay disc. indifference point, 2s delay	3.1	3.5	7.0	-2.6	-1.8	1.6	1.6	1.7	1.7
Delay disc. indifference point, 24s delay	5.1	8.1	16.3	-4.0	-2.2	2.6	2.6	2.6	2.6
Delay disc. indifference point, 4s delay	7.2	7.6	18.7	-4.3	-2.2	2.4	2.4	2.4	2.4
Delay disc. indifference point, 8s delay	2.7	4.5	5.1	-1.8	-1.8	2.3	2.3	2.3	2.2
Indifference point function ln k	1.7	5.2	14.6	3.8	2.0	-1.8	-1.7	-1.8	-1.8
Indifference point function log k	1.7	5.2	14.6	3.8	2.0	-1.8	-1.7	-1.8	-1.8
Patch foraging total patch changes 0 sec	1.1	3.2	5.0	2.2	1.8	-1.7	-1.6	-1.6	-1.7
Patch foraging total patch changes 12 sec	0.2	0.3	0.9	-0.9	0.3	-0.4	-0.4	-0.4	-0.4
Patch foraging total patch changes 18 sec	0.4	0.9	1.9	-0.2	-1.4	0.9	0.9	0.9	0.9
Patch foraging total patch changes 24 sec	0.4	1.4	1.9	-0.4	-1.4	1.3	1.3	1.3	1.2
Patch foraging total patch changes 6 sec	0.0	0.1	0.3	-0.5	0.1	-0.1	-0.1	-0.1	-0.1
Patch foraging time to switch 0 sec	1.2	4.5	16.9	-4.1	-1.3	1.5	1.5	1.5	1.5
Patch foraging water rate 0 sec	0.8	3.0	10.5	3.2	1.1	-1.3	-1.2	-1.3	-1.3
Patch foraging water rate 12 sec	0.3	1.0	4.4	2.1	0.6	-0.6	-0.6	-0.6	-0.6
Patch foraging water rate 18 sec	0.6	1.3	5.3	2.3	0.8	-0.7	-0.6	-0.7	-0.7
Patch foraging water rate 24 sec	0.7	1.0	6.0	-2.4	0.2	-0.0	-0.0	-0.0	-0.0
Patch foraging water rate 6 sec	0.4	0.6	3.8	1.9	-0.1	0.1	0.1	0.1	0.1
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	1.5	1.2	0.3	-0.4	-0.4	-0.4	-0.4
Distance traveled before self-admin	0.6	1.3	2.9	1.7	-1.0	1.0	1.0	1.0	1.0
Distance traveled after self-admin	1.2	2.2	4.5	2.1	-1.6	1.2	1.2	1.2	1.3
Extensor digitorum longus weight	0.4	1.6	2.2	-0.6	-1.5	1.4	1.4	1.3	1.3
Bone: elastic displacement	2.0	2.5	4.4	2.1	1.2	-1.5	-1.5	-1.5	-1.6
Bone: elastic work	1.9	2.5	2.9	1.2	1.6	-1.7	-1.7	-1.7	-1.7
Bone: endosteal estimation	1.0	2.5	5.1	-2.3	1.7	-1.3	-1.4	-1.3	-1.3
Bone: endosteal perimeter	0.3	0.8	4.5	-2.1	-0.3	0.4	0.3	0.4	0.4
Epididymis fat weight	0.8	4.0	4.3	-2.0	-2.1	2.0	2.0	2.0	2.0
Delta time in closed arm before/after self-admin	0.4	0.3	2.0	-1.4	0.0	0.1	0.1	0.0	-0.0
Delta time in open arm before/after self-admin	1.5	1.8	9.2	3.0	-1.1	0.2	0.2	0.2	0.2
Diff in mean of infusions in LGA sessions	2.4	4.2	19.2	4.4	-1.6	1.0	1.0	1.0	0.9
Delay discount exponential model param	7.0	9.5	17.3	4.2	2.5	-2.9	-2.9	-2.9	-2.9
Extinction: sum of active levers before priming	0.1	0.1	0.3	-0.6	-0.0	0.3	0.3	0.3	0.3
Active lever presses in extinction session 6	0.6	0.7	1.1	0.6	-1.1	0.8	0.8	0.8	0.8
Bone: final force	0.9	1.5	2.0	1.1	1.4	-1.2	-1.2	-1.2	-1.2
Bone: final moment	0.6	1.0	1.2	0.9	1.1	-1.0	-1.0	-1.0	-1.0
Food consumed during 24 hour testing period	0.2	0.4	0.5	-0.4	-0.7	0.7	0.7	0.6	0.6
Glucose	0.5	0.7	2.3	-1.5	-0.7	0.7	0.6	0.7	0.7
Heart weight	0.4	0.7	3.2	-1.8	-0.4	0.4	0.4	0.4	0.4
Delay discount hyperbolic model param	8.0	10.3	20.0	4.5	2.6	-3.0	-3.0	-3.0	-3.0
Intermittent access intake day 1-15 change	0.4	2.1	9.5	3.1	0.7	-0.8	-0.7	-0.8	-0.8
Intermittent access intake escalation	0.4	2.1	10.4	3.2	0.6	-0.7	-0.6	-0.7	-0.7
Intermittent access intake escalation 2	1.1	1.9	11.4	3.4	-0.2	-0.0	-0.0	-0.0	-0.0
Intermitt. access day 1 inactive lever presses	0.4	5.5	9.6	3.1	2.2	-2.2	-2.2	-2.1	-2.2
Intermitt. access day 15 inactive lever presses	1.1	6.0	31.1	5.6	1.1	-0.9	-0.9	-0.9	-1.0
Intermitt. access escalation Index	1.9	5.9	18.2	-4.3	-2.2	1.8	1.7	1.8	1.8
Intermittent access day 1 total infusions	1.2	3.5	18.7	4.3	-0.6	0.7	0.8	0.7	0.7
Intermittent access day 15 total infusions	1.9	4.7	27.3	5.2	-0.3	0.4	0.5	0.4	0.4
Intermittent access terminal intake (last 3 days)	3.1	5.4	31.6	5.6	-0.2	0.5	0.5	0.5	0.4
Intermittent access total infusions	3.1	3.7	21.6	4.6	-0.3	0.4	0.4	0.3	0.3
Intermittent access day 1 locomotion	2.7	5.0	29.2	5.4	-0.4	0.4	0.4	0.4	0.4
Intermittent access day 15 total locomotion	0.4	1.5	7.9	2.8	0.5	-0.6	-0.5	-0.5	-0.5
Intermittent access total locomotion	1.6	1.9	11.2	3.3	-0.2	-0.1	-0.0	-0.0	-0.0
Intermittent access standard deviation	0.5	2.8	16.9	4.1	-0.1	0.0	0.0	0.0	-0.0
Left kidney weight	0.3	2.5	11.4	-3.4	-0.9	0.8	0.8	0.8	0.8
Right kidney weight	0.1	0.7	0.9	-0.7	-0.9	0.9	0.9	0.9	0.9
Cocaine induced anxiety	0.1	0.2	0.2	-0.4	0.5	-0.5	-0.5	-0.4	-0.4
Post-drug Anxiety	0.1	0.1	0.2	0.4	0.3	-0.2	-0.2	-0.2	-0.2
Baseline Anxiety	0.0	0.0	0.0	-0.0	0.0	0.2	0.2	0.2	0.2
Tail length	0.5	2.5	3.0	-0.6	-1.7	1.7	1.7	1.7	1.7
Length with tail	0.1	0.3	1.1	-1.1	-0.5	0.4	0.3	0.4	0.4
Length without tail	0.4	1.9	2.5	-0.2	1.4	-1.5	-1.6	-1.5	-1.5
Times rat made contact with spout	0.4	0.5	2.9	-1.7	-0.0	0.2	0.2	0.2	0.2
Lifetime Intake	2.2	2.7	11.0	3.3	-1.0	1.0	1.0	1.0	1.0
Liver weight, left	0.2	0.3	1.3	1.2	0.3	-0.3	-0.3	-0.3	-0.3
Liver weight, right	1.7	2.9	3.1	1.7	1.8	-1.7	-1.7	-1.7	-1.7
Locomotor activity	3.2	4.9	6.1	-0.3	2.4	-2.5	-2.5	-2.5	-2.4
Locomotor testing distance	1.7	4.1	4.7	1.7	1.8	-2.2	-2.2	-2.1	-2.1
Locomotor testing rearing	0.7	2.7	3.2	0.5	1.7	-1.8	-1.8	-1.8	-1.8
Locomotion in novel chamber	1.7	2.3	12.9	3.6	-0.8	0.1	0.1	0.1	0.2
Locomotion in novel chamber post-restriction	0.3	0.8	1.9	0.4	-1.4	0.7	0.7	0.8	0.8
Fecal boli incidents, locomotor time 1	1.3	3.4	20.4	4.5	-0.1	0.3	0.3	0.3	0.2
Change in fecal boli incidents, locomotor task	2.3	2.4	2.6	-1.5	-1.6	1.6	1.6	1.5	1.5
Time >=10cm from walls, locomotor time 1	1.4	1.7	9.8	3.1	-0.5	0.1	0.2	0.2	0.1
Bouts of movement, locomotor time 1	0.4	0.6	0.8	0.0	0.6	-0.9	-0.8	-0.9	-0.9
Total resting periods, locomotor time 1	0.2	0.2	0.3	-0.5	0.3	-0.5	-0.5	-0.5	-0.5
Rest time, locomotor task time 1	1.1	1.8	2.7	-1.6	-1.1	1.3	1.3	1.3	1.3
Distance moved, locomotor task time 1	0.5	1.4	1.7	1.0	1.3	-1.2	-1.2	-1.2	-1.2
Vertical activity count, locomotor time 1	0.1	0.4	0.9	0.9	0.7	-0.5	-0.5	-0.4	-0.4
Time >=10cm from walls, locomotor time 2	0.8	2.2	11.8	3.4	0.3	-0.6	-0.6	-0.6	-0.6
Bouts of movement, locomotor time 2	0.6	2.0	10.5	3.2	0.5	-0.6	-0.6	-0.6	-0.6
Total resting periods, locomotor time 2	0.5	2.0	11.5	3.4	0.3	-0.4	-0.4	-0.4	-0.4
Rest time, locomotor task time 2	2.6	4.3	8.9	3.0	-2.2	1.8	1.8	1.8	1.7
Distance moved, locomotor task time 2	2.6	3.5	5.7	-0.5	2.4	-2.0	-2.0	-1.9	-1.9
Vertical activity count, locomotor time 2	3.1	7.3	10.5	0.4	3.2	-2.9	-2.9	-2.9	-2.9
Light reinforcement 1	0.4	2.0	2.5	1.6	1.5	-1.3	-1.3	-1.3	-1.3
Light reinforcement 2	0.8	1.8	7.2	2.7	1.0	-0.8	-0.8	-0.8	-0.8
Bone: marrow area	1.0	2.4	5.1	-2.3	1.6	-1.3	-1.3	-1.3	-1.3
Bone: maximum diameter	0.1	0.2	0.8	-0.9	-0.2	0.2	0.2	0.2	0.2
Bone: maximum force	0.2	0.3	0.4	0.3	0.7	-0.6	-0.6	-0.6	-0.6
Bone: maximum moment	0.1	0.1	0.1	0.3	0.3	-0.4	-0.4	-0.4	-0.4
Mean time between licks in bursts	0.0	0.2	0.5	-0.7	-0.4	0.4	0.4	0.3	0.3
Mean num. licks in bursts	0.1	0.2	0.5	-0.7	-0.2	0.5	0.5	0.5	0.5
Cd content in liver	1.6	1.8	3.3	-0.8	1.8	-1.3	-1.3	-1.3	-1.3
Co content in liver	0.0	0.0	0.0	-0.0	-0.1	0.2	0.2	0.2	0.2
Cu content in liver	2.6	3.0	3.7	-1.9	1.3	-1.8	-1.8	-1.8	-1.7
Fe content in liver	1.1	1.4	5.9	-2.4	1.0	-0.6	-0.6	-0.6	-0.6
K content in liver	1.2	1.2	5.4	2.3	-0.7	0.5	0.6	0.6	0.6
Mg content in liver	2.9	3.2	17.2	4.1	-0.8	0.6	0.6	0.6	0.6
Mn content in liver	4.9	5.5	13.9	3.7	2.2	-1.9	-1.9	-1.9	-1.9
Na content in liver	1.5	1.7	8.2	-2.9	-0.8	0.6	0.5	0.6	0.6
Rb content in liver	1.1	1.2	7.2	-2.7	-0.2	0.2	0.2	0.2	0.3
Se content in liver	1.3	1.6	8.5	2.9	0.8	-0.2	-0.2	-0.2	-0.2
Sr content in liver	2.3	2.0	6.6	-2.6	-1.0	1.1	1.0	1.0	1.0
Zn content in liver	0.0	0.0	0.1	-0.2	-0.2	0.1	0.1	0.1	0.1
Bone: minimum diameter	0.3	0.7	0.8	-0.9	0.7	-0.8	-0.8	-0.8	-0.8
Time in familiar zone, hab. session 1	1.5	1.6	3.6	1.9	-1.3	1.0	1.0	1.0	1.0
Time in novel zone, hab. session 1	3.0	3.4	5.2	-1.3	2.3	-1.8	-1.8	-1.8	-1.8
Total zone transitions, hab. session 1	0.6	0.9	1.2	-0.4	-1.1	1.0	1.0	1.0	1.0
Total locomotion distance, hab. session 1	1.3	1.9	2.3	-0.4	-1.5	1.5	1.5	1.5	1.5
Locomotion velocity, hab. session 1	0.9	1.3	1.8	-0.3	-1.4	1.2	1.2	1.2	1.2
Time in familiar zone, hab. session 2	0.1	0.1	0.2	0.3	-0.4	0.2	0.2	0.2	0.2
Time in novel zone, hab. session 2	0.1	0.1	0.3	-0.1	0.6	-0.4	-0.3	-0.4	-0.4
Total zone transitions, hab. session 2	0.5	0.7	1.2	-0.2	-1.1	0.8	0.9	0.8	0.8
Total locomotion distance, hab. session 2	0.1	0.2	0.3	-0.3	-0.5	0.4	0.4	0.4	0.4
Locomotion velocity, hab. session 2	0.1	0.1	0.3	-0.6	-0.4	0.3	0.3	0.3	0.3
Novel to familiar place preference ratio	0.7	1.0	3.9	2.0	0.7	-0.6	-0.6	-0.6	-0.6
Novelty place preference	0.7	1.0	3.7	1.9	0.8	-0.6	-0.6	-0.6	-0.6
Time in novel zone, NPP test	0.6	0.7	3.6	1.9	0.5	-0.3	-0.3	-0.3	-0.4
Total zone transitions, NPP test	0.0	0.0	0.0	0.0	-0.1	0.1	0.1	0.0	0.0
Total locomotion distance, NPP test	0.5	0.7	1.2	0.3	1.1	-0.9	-0.9	-0.9	-0.9
Locomotion velocity, NPP test	0.5	0.8	1.2	0.3	1.1	-0.9	-0.9	-0.9	-0.9
Intraocular pressure	1.0	1.6	3.7	0.0	1.9	-1.2	-1.2	-1.2	-1.2
Delta distance traveled before/after self-admin	0.7	0.8	4.1	2.0	-0.3	-0.4	-0.4	-0.4	-0.3
Delta ambulatory time before/after self-admin	0.8	1.4	4.6	2.1	0.5	-1.0	-1.0	-1.0	-0.9
Parametrial fat weight	0.9	2.2	3.2	-1.8	1.4	-1.4	-1.4	-1.4	-1.4
Pavlov. Cond. lever latency	0.1	0.1	0.2	-0.5	-0.2	0.3	0.3	0.3	0.3
Pavlov. Cond. magazine entry latency	1.4	1.8	5.5	2.3	1.1	-1.0	-1.0	-1.0	-1.1
Pavlov. Cond. change in total contacts	0.3	0.3	1.7	1.3	0.0	-0.1	-0.1	-0.2	-0.2
Pavlov. Cond. index score	0.3	0.4	1.7	1.3	0.3	-0.3	-0.3	-0.3	-0.3
Pavlov. Cond. latency score	0.5	0.6	1.2	1.1	0.7	-0.7	-0.7	-0.7	-0.7
Pavlov. Cond. lever contacts	0.3	0.4	0.8	0.9	0.5	-0.5	-0.5	-0.6	-0.6
Pavlov. Cond. magazine entry number	1.2	1.6	6.2	-2.5	-0.8	0.8	0.8	0.8	0.8
Pavlov. Cond. intertrial magazine entries	1.6	2.0	11.6	-3.4	0.5	-0.1	-0.1	-0.1	-0.0
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	1.6	1.3	0.3	-0.2	-0.2	-0.2	-0.3
Pavlov. Cond. response bias	0.3	0.4	2.2	1.5	0.2	-0.2	-0.1	-0.2	-0.2
Pavlov. Cond. lever latency	0.4	0.6	1.4	-1.2	-1.0	0.5	0.5	0.5	0.5
Pavlov. Cond. magazine entry latency	0.7	0.9	2.3	1.5	0.8	-0.8	-0.8	-0.8	-0.8
Pavlov. Cond. change in total contacts	1.1	2.7	4.7	0.5	2.2	-1.7	-1.7	-1.7	-1.7
Pavlov. Cond. index score	0.9	1.5	2.1	1.4	1.4	-1.1	-1.1	-1.1	-1.1
Pavlov. Cond. latency score	0.6	0.9	1.5	1.2	1.1	-0.8	-0.8	-0.8	-0.8
Pavlov. Cond. lever contacts	0.3	0.4	1.5	1.2	0.7	-0.3	-0.2	-0.3	-0.3
Pavlov. Cond. magazine entry number	2.0	2.6	3.6	-1.9	-1.7	1.5	1.5	1.5	1.5
Pavlov. Cond. intertrial magazine entries	1.1	2.3	3.8	-0.8	-1.9	1.6	1.6	1.5	1.5
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.7	2.6	1.6	1.5	-1.1	-1.1	-1.2	-1.2
Pavlov. Cond. response bias	0.9	1.3	2.4	1.5	1.3	-1.0	-0.9	-1.0	-1.0
Time in closed arm before self-admin	0.5	0.8	1.1	0.8	0.5	-1.0	-1.1	-1.0	-1.0
Time in closed arm after self-admin	0.3	0.3	1.5	-1.2	-0.0	-0.3	-0.3	-0.3	-0.3
Time in open arm before self-admin	1.6	1.9	3.8	-1.7	1.9	-1.1	-1.1	-1.1	-1.1
Time in open arm after self-admin	0.3	0.3	1.8	1.3	-0.3	0.2	0.2	0.2	0.2
Bone: periosteal estimation	0.8	1.8	2.4	-0.9	1.5	-1.4	-1.4	-1.4	-1.4
Bone: periosteal perimeter	0.2	0.4	0.8	-0.9	-0.7	0.6	0.5	0.6	0.6
Bone: post-yield work	0.4	0.7	1.0	-1.0	-0.5	0.9	0.9	0.9	0.9
Progressive ratio test 1 active lever presses	2.5	4.3	10.9	3.3	-1.6	1.8	1.8	1.8	1.7
Progressive ratio test 1 breakpoint	2.4	4.2	9.2	3.0	-1.6	1.8	1.8	1.8	1.8
Progressive ratio test 1 inactive lever presses	0.3	0.8	4.1	2.0	-0.5	0.4	0.4	0.4	0.4
Progressive ratio test 2 active lever presses	2.6	3.7	9.4	3.1	-1.5	1.6	1.7	1.6	1.6
Progressive ratio test 2 breakpoint	3.0	3.9	10.7	3.3	-1.5	1.6	1.7	1.6	1.6
Progressive ratio test 2 inactive lever presses	0.0	0.1	0.4	0.7	-0.2	0.3	0.3	0.3	0.3
Incentive Sensitization - Responses	0.8	2.1	12.4	3.5	-0.3	0.2	0.3	0.2	0.2
Incentive Sensitization - Breakpoint	1.1	2.5	14.6	3.8	-0.2	0.1	0.2	0.1	0.1
Sum of active levers in priming session hrs 5-6	3.9	3.7	16.3	4.0	-1.2	1.0	1.1	1.0	1.0
Progressive ratio	0.6	1.7	2.7	-0.7	-1.6	1.3	1.3	1.3	1.3
Food seeking constrained by brief footshock	0.5	0.7	1.7	-1.3	1.0	-0.6	-0.6	-0.6	-0.6
Seeking ratio, punishment vs. effort	0.6	1.4	2.5	-1.0	1.6	-1.1	-1.1	-1.1	-1.1
Retroperitoneal fat weight	0.1	0.5	1.9	-1.4	-0.5	0.5	0.5	0.5	0.5
Reaction time number correct	0.8	3.0	17.9	4.2	-0.0	0.1	0.1	0.1	0.0
Reaction time mean minus median	0.4	2.5	14.0	-3.7	-0.5	0.5	0.5	0.5	0.5
Reaction time mean minus median AUC	0.2	1.5	7.8	-2.8	0.5	-0.5	-0.5	-0.4	-0.4
Reaction time num false alarms	0.2	0.3	0.5	0.4	0.7	-0.6	-0.5	-0.5	-0.6
Reaction time num false alarms AUC	0.2	0.4	2.1	1.5	0.1	-0.1	-0.1	-0.1	-0.1
Reaction time trials correct on left	0.8	3.0	17.9	4.2	-0.0	0.1	0.1	0.1	0.0
Reaction time trials on left	0.9	3.0	18.0	4.2	-0.2	0.2	0.3	0.2	0.2
Reaction time mean	0.3	0.7	3.9	-2.0	-0.6	0.1	0.1	0.1	0.1
Reaction time mean AUC	0.3	0.8	4.1	-2.0	-0.6	0.1	0.1	0.1	0.2
Median of all reaction times	0.1	0.2	1.1	-1.0	-0.4	-0.0	-0.1	-0.0	-0.0
Reaction time omissions	1.5	2.5	3.0	-0.9	-1.7	1.7	1.7	1.7	1.7
Reaction time false alarm rate	0.1	0.1	0.5	-0.7	0.3	-0.3	-0.3	-0.2	-0.2
Reaction time premature initiation rate	0.4	0.6	0.7	-0.6	-0.8	0.8	0.8	0.8	0.8
Reaction time premature initiations	0.2	0.6	1.7	1.3	-0.6	0.6	0.6	0.6	0.6
Std. dev. reaction times	0.6	1.8	9.8	-3.1	-0.7	0.4	0.4	0.4	0.5
Reaction time trials completed	0.9	3.0	18.0	4.2	-0.2	0.2	0.3	0.2	0.2
Reaction time trials AUC	0.8	2.9	17.4	4.2	0.1	-0.0	0.0	-0.0	-0.1
Run reversals in cocaine runway, females	2.3	2.5	14.6	-3.8	-0.7	0.2	0.1	0.2	0.3
Run reversals in cocaine runway, males	0.2	0.2	0.3	-0.6	0.6	-0.4	-0.4	-0.3	-0.3
Latency to leave start box in cocaine runway	1.6	2.2	12.7	-3.6	-0.4	0.2	0.2	0.2	0.3
Latency to leave start box in cocaine runway, F	1.6	1.9	9.2	-3.0	-0.8	0.7	0.7	0.7	0.7
Latency to leave start box in cocaine runway, M	0.9	0.9	4.3	-2.1	0.2	-0.5	-0.5	-0.5	-0.5
Std. dev. time between licks in bursts	0.0	0.1	0.4	0.6	0.1	-0.1	-0.1	-0.1	-0.1
Total sessions with >9 infusions	3.4	4.3	13.2	3.6	-1.6	1.6	1.6	1.6	1.5
Short access day 1 total inactive lever presses	0.3	0.7	0.9	0.6	0.7	-1.0	-0.9	-0.9	-0.9
Short access day 10 total inactive lever presses	1.3	8.9	24.5	4.9	2.6	-2.4	-2.3	-2.4	-2.4
Short access day 1 total infusions	1.2	2.4	2.5	1.3	-1.6	1.6	1.6	1.6	1.6
Short access day 10 total infusions	3.2	5.3	21.1	4.6	-1.6	1.5	1.5	1.5	1.4
Short access total infusions	1.8	2.5	5.0	2.2	-1.5	1.4	1.4	1.4	1.4
Short access day 1 locomotion	0.7	1.2	3.0	1.7	-1.1	0.9	0.9	0.9	0.9
Short access day 10 total locomotion	1.4	5.5	31.7	5.6	-0.5	0.5	0.6	0.6	0.5
Short access total locomotion	1.5	2.2	10.2	3.2	-0.9	0.7	0.7	0.8	0.8
One hour access (0.3 mA shock)	0.3	0.4	1.3	1.2	-0.7	0.4	0.4	0.4	0.4
Compulsive drug intake	0.2	0.3	0.9	-0.9	0.2	-0.5	-0.5	-0.5	-0.5
One hour access (shock baseline)	0.3	0.9	2.2	1.5	-0.8	0.8	0.8	0.8	0.8
Social response proportion	0.1	0.1	0.2	0.4	-0.5	0.3	0.3	0.3	0.3
Social responses	0.2	0.3	1.6	1.3	0.1	-0.1	-0.1	-0.1	-0.1
Social time	1.0	1.5	2.0	-0.6	-1.4	1.3	1.3	1.3	1.3
Soleus weight	4.6	13.5	17.7	-4.2	-3.5	3.6	3.5	3.6	3.6
Bone: stiffness	0.0	0.0	0.0	0.0	0.1	0.1	0.1	0.1	0.1
Tibialis anterior weight	0.7	2.5	8.9	-3.0	-0.8	1.2	1.2	1.2	1.2
Time to tail flick, vehicle, before self-admin	0.4	0.4	1.4	1.2	0.4	-0.6	-0.5	-0.5	-0.5
Time to tail flick, vehicle, after self-admin	0.4	0.9	1.0	0.9	-0.8	1.0	1.0	1.0	1.0
Time to tail flick, test, before self-admin	0.2	0.2	0.7	0.8	0.5	-0.3	-0.3	-0.3	-0.3
Time to tail flick, test, after self-admin	0.5	0.6	2.0	-1.4	-0.6	0.5	0.5	0.5	0.5
Delta time to tail flick, vehicle, before/after SA	1.6	1.7	2.0	-1.1	-1.2	1.4	1.4	1.4	1.4
Delta time to tail flick, test, before/after SA	0.2	0.2	0.6	-0.7	-0.8	0.3	0.3	0.3	0.3
Tibia length	0.2	0.7	3.4	1.9	-0.1	-0.4	-0.4	-0.4	-0.4
Ambulatory time before self-admin	0.3	0.8	1.1	0.8	-1.1	0.8	0.8	0.9	0.9
Ambulatory time after self-admin	0.7	1.1	6.4	2.5	-0.6	-0.1	-0.1	-0.1	-0.1
Bone: tissue strength	0.1	0.1	0.6	-0.8	0.0	-0.2	-0.3	-0.2	-0.2
Total heroin consumption	1.8	2.1	12.4	3.5	0.1	-0.3	-0.3	-0.3	-0.3
Bone: trabecular number	0.4	0.7	1.9	-1.4	-0.6	0.8	0.7	0.7	0.7
Bone: trabecular spacing	0.5	0.8	4.3	2.1	-0.3	-0.2	-0.2	-0.2	-0.2
Bone: trabecular thickness	0.5	0.7	0.9	0.0	1.0	-0.9	-0.9	-0.9	-0.9
Bone: trabecular tissue density	1.5	2.6	6.3	-2.5	1.3	-1.4	-1.4	-1.4	-1.3
Water consumed over 24 hours	0.2	0.4	1.5	-1.2	-0.4	0.5	0.5	0.5	0.5
Number of responses in last shaping day	0.5	0.6	2.2	1.5	-0.5	0.5	0.5	0.6	0.6