Hub : Genes

Nudt3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	Nudt3	0.33	0.1	1.0e-08	0.14	0.1	0.1	0.13	6.1e-08	4.4e-06	5.2e-06	1.7e-07
2	NAcc	gene expression	Nudt3	0.2	0.08	2.9e-10	0.09	0.1	0.11	0.1	5.4e-11	5.0e-12	2.2e-12	7.3e-12
3	Adipose	gene expression	Nudt3	0.08	0.05	6.6e-04	0.01	0.01	0.02	0.01	2.5e-02	9.0e-03	3.5e-03	3.0e-02
4	Brain	gene expression	Nudt3	0.22	0.08	8.4e-15	0.16	0.15	0.17	0.18	1.9e-14	4.4e-14	1.0e-15	1.7e-16
5	Liver	gene expression	Nudt3	0.16	0.07	2.9e-07	0.02	0.05	0.05	0.05	9.7e-04	3.1e-06	6.3e-06	5.8e-06
6	pVTA	gene expression	Nudt3	0.31	0.1	8.9e-08	0.12	0.18	0.19	0.18	6.3e-06	3.8e-08	1.4e-08	3.7e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.2	0.3	0.6	0.8	0.6	0.0	-0.5	-0.4	0.5
Area under the delay curve	0.2	0.3	0.6	0.2	0.4	0.7	0.1	0.5	0.8
BMI with tail	0.6	1.9	4.9	1.7	1.2	2.2	-1.0	-1.1	0.2
BMI without tail	0.3	0.7	1.9	-0.3	-1.3	0.3	0.5	-0.4	-1.4
Body weight	0.7	2.9	5.3	-2.0	-1.6	0.1	2.1	2.3	-1.0
Weight adjusted by age	1.5	1.7	3.4	-1.7	-1.1	-0.4	1.6	1.9	-0.3
Bone surface	0.7	1.3	2.4	-0.7	-1.2	-1.5	1.2	0.8	-1.1
Bone volume	0.1	0.1	0.4	0.0	-0.2	-0.6	0.3	0.2	-0.3
Breakpoint value in progressive ratio session	0.2	0.2	0.6	-0.3	-0.6	-0.5	0.2	0.1	-0.7
Number of licking bursts	1.0	1.2	2.1	-0.3	-1.1	-1.5	1.0	0.8	-1.4
Context. condit. distance diff. score	2.5	3.0	5.2	-1.6	-1.4	-2.3	1.9	2.0	-1.0
Locomotion velocity, session 1	0.3	0.3	0.6	0.1	-0.7	-0.4	0.7	0.8	0.5
Locomotion distance, session 1	0.8	1.0	2.8	1.7	0.7	0.1	-1.0	-1.2	0.6
Locomotion velocity, session 2	0.8	0.9	2.2	-0.9	-1.0	-1.5	0.7	0.5	-0.9
Locomotion distance, session 2	0.2	0.3	0.5	0.7	0.7	-0.3	-0.5	-0.3	0.7
Locomotion velocity, session 3	0.2	0.2	0.8	0.2	0.0	0.1	-0.5	-0.9	-0.1
Locomotion distance, session 3	0.4	0.4	0.9	0.9	0.7	0.2	-0.7	-0.7	0.4
Stereotopy head waving bouts, day 3	3.3	3.9	5.0	-2.2	-2.2	-1.7	2.1	1.8	-1.7
Stereotopy head waving duration, day 3	1.0	1.2	2.0	-1.4	-1.3	-0.8	1.2	1.0	-0.4
Locomotion velocity, session 7	0.5	0.6	1.8	0.8	0.9	0.3	-0.2	0.1	1.4
Locomotion distance, session 7	0.8	1.0	2.9	0.7	1.4	0.3	-0.8	-0.2	1.7
Stereotopy head waving bouts, day 7	0.1	0.2	0.4	0.2	-0.1	0.6	-0.3	-0.6	0.3
Stereotopy head waving duration, day 7	0.1	0.1	0.4	0.1	-0.6	0.5	0.2	-0.2	-0.4
Locomotion velocity, session 8	5.4	6.4	7.7	-2.7	-2.7	-2.8	2.7	2.7	-1.5
Locomotion distance, session 8	1.0	1.4	4.6	-0.9	-0.6	-2.2	1.0	1.2	-0.5
Degree of sensitization distance	1.1	1.1	1.7	-1.3	-0.7	-1.2	1.0	1.3	-0.6
Degree of sensitization stereotypy	0.7	0.8	1.4	1.0	0.4	1.0	-0.9	-1.2	0.4
Conditioned locomotion	1.1	1.3	2.3	-1.5	-0.5	-1.4	0.9	1.0	-1.2
Cocaine response after cond. corrected	0.1	0.1	0.5	0.4	0.1	-0.4	-0.0	-0.1	-0.7
Cocaine response after cond. not corrected	0.9	1.0	2.1	-0.6	-1.0	-1.1	1.0	0.6	-1.4
Cocaine response before conditioning	2.1	2.5	3.9	-1.7	-2.0	-1.2	1.8	1.4	-1.4
Saline control response	1.8	2.4	3.7	1.4	1.5	1.9	-1.7	-1.7	0.6
Bone: connectivity density	0.1	0.1	0.4	-0.0	-0.1	-0.7	0.5	0.3	-0.1
Bone: cortical apparent density	1.1	1.4	2.3	1.5	1.2	1.1	-1.4	-1.4	0.3
Bone: cortical area	0.0	0.1	0.2	0.2	-0.3	0.1	0.3	-0.2	-0.4
Bone: cortical porosity	1.6	1.8	5.2	0.4	1.2	1.4	-1.2	-0.7	2.3
Bone: cortical porosity	0.5	0.5	2.3	-0.5	0.2	0.7	0.0	0.4	1.5
Bone: cortical thickness	3.6	5.9	9.2	3.0	2.2	2.3	-2.5	-2.9	1.2
Bone: cortical thickness	3.3	3.8	6.7	2.4	1.9	1.4	-2.2	-2.6	0.3
Bone: cortical tissue density	0.7	1.0	1.5	1.2	1.0	0.9	-1.2	-1.1	0.2
Condit. Reinf. active minus inactive responses	0.2	0.2	0.8	-0.1	0.4	0.5	-0.2	0.1	0.9
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.6	0.3	0.4	0.8	-0.5	-0.4	0.3
Condit. Reinf. active responses	0.2	0.3	0.7	0.2	0.7	0.7	-0.2	0.1	0.8
Condit. Reinf. inactive responses	0.6	0.7	1.6	1.0	1.3	0.8	-0.7	-0.4	0.8
Incentive salience index mean	0.4	0.5	1.1	-0.9	-0.4	-0.5	0.8	1.1	0.2
Condit. Reinf. lever presses	1.0	1.4	2.1	-1.3	-0.9	-1.3	1.3	1.5	-0.5
Condit. Reinf. active minus inactive responses	0.2	0.2	0.9	-0.9	-0.2	-0.4	-0.0	0.4	0.3
Condit. Reinf. active-inactive response ratio	0.5	0.5	1.6	-1.3	-0.6	-0.4	0.5	0.9	-0.1
Condit. Reinf. active responses	0.1	0.2	0.5	-0.7	0.2	-0.5	-0.4	0.0	0.4
Condit. Reinf. inactive responses	0.2	0.3	0.6	0.2	0.6	-0.2	-0.8	-0.7	0.1
Condit. Reinf. lever presses	0.5	0.7	1.8	0.4	0.9	0.5	-1.0	-0.6	1.3
Condit. Reinf. lever reinforcers received	0.1	0.2	0.2	-0.5	0.3	-0.4	-0.5	-0.0	0.5
Conditioned reinforcement - actives	0.2	0.2	0.7	0.0	0.5	0.2	0.1	0.6	0.8
Conditioned reinforcement - inactives	0.5	0.5	0.9	0.6	0.7	1.0	-0.7	-0.4	0.8
Conditioned locomotion	0.7	0.8	2.1	-0.4	0.5	0.5	0.6	1.5	1.3
Patch foraging indifference point 0 sec	1.5	2.5	3.4	1.8	1.7	1.8	-1.6	-1.6	0.5
Patch foraging indifference point AUC	2.5	2.8	4.3	-1.9	-2.1	-1.8	1.5	0.9	-1.7
Delay disc. indifference point, 0s delay	0.2	0.2	0.6	-0.3	-0.1	-0.1	0.5	0.8	0.1
Delay disc. indifference point, 16s delay	1.6	1.6	2.1	1.4	1.5	1.5	-1.1	-0.7	1.4
Delay disc. indifference point, 2s delay	0.6	0.7	1.4	-1.0	-0.6	-0.1	1.0	1.2	0.4
Delay disc. indifference point, 24s delay	1.9	1.8	4.1	1.1	1.5	2.0	-0.9	-0.1	1.6
Delay disc. indifference point, 4s delay	0.6	0.7	1.2	-0.7	-0.8	-0.4	1.1	1.0	-0.8
Delay disc. indifference point, 8s delay	0.3	0.3	0.8	-0.0	0.2	0.8	0.1	0.5	0.9
Indifference point function ln k	0.0	0.0	0.1	0.3	0.1	-0.1	-0.0	-0.1	0.2
Indifference point function log k	0.0	0.0	0.1	0.3	0.1	-0.1	-0.0	-0.1	0.2
Patch foraging total patch changes 0 sec	2.0	3.3	4.3	2.1	1.9	2.0	-1.9	-1.9	0.8
Patch foraging total patch changes 12 sec	0.6	0.8	2.1	1.0	0.5	0.6	-0.9	-1.4	-0.1
Patch foraging total patch changes 18 sec	2.1	2.7	4.6	1.8	1.6	1.3	-2.0	-2.1	0.2
Patch foraging total patch changes 24 sec	4.3	5.2	6.9	2.6	2.5	1.9	-2.6	-2.3	1.5
Patch foraging total patch changes 6 sec	3.0	4.4	5.6	2.4	2.2	2.2	-2.2	-2.2	1.3
Patch foraging time to switch 0 sec	1.6	2.5	4.0	1.6	2.0	1.6	-1.8	-1.4	0.8
Patch foraging water rate 0 sec	0.1	0.1	0.3	0.2	-0.1	0.0	0.6	0.5	0.2
Patch foraging water rate 12 sec	0.9	1.4	2.3	1.3	1.3	0.5	-1.5	-1.5	0.7
Patch foraging water rate 18 sec	0.1	0.2	0.5	0.6	0.2	0.7	0.3	0.3	0.2
Patch foraging water rate 24 sec	0.1	0.2	0.6	0.8	0.1	-0.0	-0.1	-0.6	-0.3
Patch foraging water rate 6 sec	0.2	0.3	0.6	0.7	0.3	-0.2	-0.5	-0.7	0.1
Seeking ratio, delayed vs. immediate footshock	0.8	0.9	2.3	-0.6	-1.1	-1.0	0.1	-0.8	-1.5
Distance traveled before self-admin	2.6	2.8	4.7	-1.4	-1.8	-2.0	1.5	0.7	-2.2
Distance traveled after self-admin	2.4	2.6	5.2	-1.4	-2.0	-1.8	1.2	0.3	-2.3
Extensor digitorum longus weight	0.9	3.7	4.5	-2.0	-2.0	-2.1	2.1	2.0	-1.0
Bone: elastic displacement	2.0	2.2	4.3	1.4	1.3	1.7	-1.3	-1.0	2.1
Bone: elastic work	0.9	1.1	1.8	1.1	1.0	1.3	-0.8	-0.7	1.3
Bone: endosteal estimation	6.1	13.2	17.2	-3.9	-3.8	-2.7	4.1	3.9	-3.1
Bone: endosteal perimeter	4.3	9.0	11.1	-3.1	-3.1	-2.6	3.3	3.1	-2.7
Epididymis fat weight	10.8	25.2	30.5	5.5	5.3	5.5	-5.2	-5.0	3.4
Delta time in closed arm before/after self-admin	0.2	0.2	0.6	0.2	0.4	0.7	-0.3	-0.2	0.7
Delta time in open arm before/after self-admin	0.0	0.0	0.1	-0.0	-0.1	-0.1	0.1	0.3	-0.2
Diff in mean of infusions in LGA sessions	0.1	0.1	0.3	0.5	0.5	0.1	-0.4	-0.2	0.3
Delay discount exponential model param	0.3	0.3	0.7	-0.2	-0.5	-0.8	0.0	-0.4	-0.9
Extinction: sum of active levers before priming	0.0	0.0	0.1	0.2	0.1	0.0	-0.2	-0.3	0.2
Active lever presses in extinction session 6	1.8	1.8	3.7	0.9	1.4	1.9	-1.0	-0.0	1.7
Bone: final force	0.6	0.9	1.9	1.4	1.1	1.2	-0.6	-0.7	-0.2
Bone: final moment	0.4	0.7	1.6	1.2	0.9	1.3	-0.3	-0.3	-0.0
Food consumed during 24 hour testing period	0.7	0.8	1.5	-1.2	-0.8	-0.7	0.9	0.8	-0.9
Glucose	5.2	7.8	15.3	-2.9	-2.6	-2.0	3.4	3.9	-0.8
Heart weight	0.2	0.2	1.0	0.4	-0.0	0.4	0.0	0.2	1.0
Delay discount hyperbolic model param	0.2	0.2	0.4	0.1	-0.1	-0.5	-0.3	-0.5	-0.6
Intermittent access intake day 1-15 change	0.4	0.4	1.3	-0.4	-0.6	-0.4	0.1	-0.4	-1.2
Intermittent access intake escalation	1.7	1.6	3.2	-1.3	-1.5	-1.2	1.1	0.4	-1.8
Intermittent access intake escalation 2	6.5	6.4	8.3	-2.9	-2.9	-2.4	2.8	2.1	-2.0
Intermitt. access day 1 inactive lever presses	0.8	0.9	2.5	-0.1	-0.9	-1.2	0.3	-0.7	-1.6
Intermitt. access day 15 inactive lever presses	0.4	0.5	1.3	-0.6	-0.8	-0.5	0.3	-0.3	-1.2
Intermitt. access escalation Index	0.5	0.4	1.0	0.2	-0.5	-1.0	0.2	-0.5	-1.0
Intermittent access day 1 total infusions	1.1	1.3	4.1	0.5	1.1	1.2	-0.5	0.6	2.0
Intermittent access day 15 total infusions	0.1	0.1	0.2	0.0	0.2	0.4	-0.1	0.2	0.4
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.5	-0.1	0.2	0.5	0.1	0.5	0.7
Intermittent access total infusions	0.5	0.6	1.7	0.2	0.6	1.0	-0.2	0.5	1.3
Intermittent access day 1 locomotion	0.1	0.1	0.3	-0.2	0.0	-0.0	0.2	0.5	0.5
Intermittent access day 15 total locomotion	1.0	1.1	1.9	-1.4	-0.9	-0.5	1.2	1.4	-0.4
Intermittent access total locomotion	0.9	1.1	2.5	-1.3	-0.7	-0.4	1.2	1.6	-0.1
Intermittent access standard deviation	0.2	0.2	0.6	0.2	0.0	0.4	-0.4	-0.8	-0.7
Left kidney weight	0.2	0.5	1.3	-1.2	-0.5	-0.2	0.5	1.1	-0.4
Right kidney weight	1.3	3.7	4.9	-2.2	-2.1	-1.6	2.0	1.7	-1.9
Cocaine induced anxiety	2.9	3.3	6.6	-1.3	-1.9	-2.5	1.4	0.3	-2.6
Post-drug Anxiety	2.3	2.5	5.2	-1.3	-1.6	-1.9	1.4	0.4	-2.3
Baseline Anxiety	2.0	2.2	4.3	1.2	1.6	2.1	-1.3	-0.7	1.6
Tail length	6.4	19.4	28.2	-5.0	-5.3	-3.7	4.8	4.0	-3.2
Length with tail	3.1	11.3	17.3	-4.2	-3.5	-2.5	3.8	4.0	-1.6
Length without tail	0.7	1.6	4.9	-1.5	-0.4	-0.4	1.4	2.2	0.2
Times rat made contact with spout	2.8	3.3	4.1	1.8	1.7	1.6	-2.0	-2.0	1.7
Lifetime Intake	0.6	0.7	2.1	0.2	0.7	1.1	-0.2	0.6	1.5
Liver weight, left	4.0	6.5	9.2	-3.0	-2.7	-2.3	2.7	2.4	-2.1
Liver weight, right	10.2	16.9	24.3	-4.9	-4.2	-4.5	3.9	3.7	-3.2
Locomotor activity	1.2	1.9	5.7	-0.1	-1.7	-1.2	1.1	0.1	-2.4
Locomotor testing distance	0.5	0.9	2.7	1.1	-0.5	-0.4	-0.1	-1.0	-1.7
Locomotor testing rearing	0.8	1.2	4.1	-0.1	-1.0	-1.1	0.8	0.2	-2.0
Locomotion in novel chamber	0.0	0.1	0.1	0.2	0.1	0.2	0.3	0.3	0.3
Locomotion in novel chamber post-restriction	0.2	0.2	0.5	0.2	0.4	0.7	-0.5	-0.3	0.3
Fecal boli incidents, locomotor time 1	0.2	0.2	0.6	-0.1	0.4	0.5	-0.1	0.5	0.8
Change in fecal boli incidents, locomotor task	0.3	0.3	0.5	-0.4	-0.7	-0.5	0.7	0.1	-0.7
Time >=10cm from walls, locomotor time 1	2.6	2.6	5.2	-1.4	-1.6	-1.4	1.7	1.0	-2.3
Bouts of movement, locomotor time 1	1.2	1.3	2.0	-1.0	-1.4	-1.4	0.9	0.4	-1.3
Total resting periods, locomotor time 1	1.7	1.9	2.8	-1.4	-1.7	-1.6	1.3	0.8	-1.3
Rest time, locomotor task time 1	0.7	0.8	1.3	-0.9	-0.8	-1.0	1.1	1.0	-0.4
Distance moved, locomotor task time 1	0.2	0.2	0.6	0.4	0.4	0.8	-0.5	-0.5	-0.0
Vertical activity count, locomotor time 1	0.2	0.2	0.6	0.0	0.0	0.7	-0.2	-0.4	-0.4
Time >=10cm from walls, locomotor time 2	0.4	0.4	1.2	-0.3	-0.0	0.7	0.8	1.1	-0.3
Bouts of movement, locomotor time 2	4.1	4.4	7.1	-2.4	-2.7	-2.2	1.9	1.1	-2.0
Total resting periods, locomotor time 2	4.9	5.3	8.2	-2.6	-2.9	-2.5	2.1	1.2	-2.1
Rest time, locomotor task time 2	4.3	5.0	6.8	-2.0	-2.2	-2.6	2.3	1.8	-2.4
Distance moved, locomotor task time 2	2.4	2.8	6.0	1.2	1.8	2.5	-1.3	-0.6	2.0
Vertical activity count, locomotor time 2	1.1	1.2	3.3	0.5	1.0	1.8	-0.6	-0.2	1.5
Light reinforcement 1	0.4	0.8	2.8	0.2	-0.5	-0.7	-0.3	-1.0	-1.7
Light reinforcement 2	0.8	1.0	1.7	-1.3	-0.8	-1.2	0.8	0.4	-1.3
Bone: marrow area	6.0	13.1	17.1	-3.9	-3.8	-2.6	4.1	3.9	-3.1
Bone: maximum diameter	3.5	6.4	8.2	-2.7	-2.8	-2.4	2.9	2.5	-1.9
Bone: maximum force	0.1	0.2	0.8	0.9	0.4	0.6	0.0	-0.1	-0.2
Bone: maximum moment	0.1	0.2	0.5	0.7	0.2	0.7	0.3	0.4	0.0
Mean time between licks in bursts	4.4	6.2	13.1	-2.9	-2.0	-3.6	2.0	2.1	-1.8
Mean num. licks in bursts	2.9	3.4	4.6	1.2	1.7	2.1	-1.9	-1.8	2.1
Cd content in liver	1.4	1.6	4.1	0.7	1.3	2.0	-0.8	-0.2	1.5
Co content in liver	2.0	2.3	3.9	1.8	1.5	2.0	-1.4	-1.3	0.6
Cu content in liver	4.9	5.9	9.5	3.1	2.3	2.1	-2.6	-2.0	2.3
Fe content in liver	0.6	0.7	1.6	0.7	1.2	0.8	-0.6	0.2	1.3
K content in liver	0.7	0.6	2.1	-0.7	-0.4	-1.5	0.6	0.8	-0.1
Mg content in liver	2.4	2.4	5.3	-1.4	-1.3	-2.3	1.5	1.8	-0.5
Mn content in liver	7.0	8.0	11.5	-2.7	-2.7	-3.4	3.0	3.0	-2.1
Na content in liver	0.0	0.0	0.1	-0.2	-0.2	-0.3	-0.1	-0.2	0.1
Rb content in liver	0.4	0.5	1.7	-0.3	-0.4	-0.2	1.0	1.3	0.1
Se content in liver	4.5	5.5	9.1	-2.8	-2.3	-3.0	2.2	2.3	-1.0
Sr content in liver	0.3	0.3	0.6	-0.2	0.4	0.8	-0.1	0.6	0.8
Zn content in liver	0.5	0.6	1.7	-0.7	0.1	-0.2	0.3	1.3	1.0
Bone: minimum diameter	2.5	4.6	6.6	-2.2	-2.3	-1.7	2.6	2.2	-1.8
Time in familiar zone, hab. session 1	2.4	2.2	3.2	1.1	1.8	1.4	-1.6	-1.3	1.7
Time in novel zone, hab. session 1	1.2	1.2	2.1	-0.5	-1.4	-0.9	1.2	0.9	-1.3
Total zone transitions, hab. session 1	0.6	0.9	2.5	1.6	0.5	0.1	-1.0	-1.3	0.0
Total locomotion distance, hab. session 1	0.4	0.6	1.4	1.1	0.3	-0.5	-0.8	-1.2	0.1
Locomotion velocity, hab. session 1	0.4	0.6	1.5	0.8	0.4	-0.5	-0.9	-1.2	0.2
Time in familiar zone, hab. session 2	0.7	0.8	2.1	-0.0	-0.3	-1.2	-0.3	-0.9	-1.5
Time in novel zone, hab. session 2	0.9	0.9	2.1	0.2	0.2	1.4	0.5	0.9	1.4
Total zone transitions, hab. session 2	0.5	0.7	1.5	1.0	-0.2	-0.9	-0.3	-0.8	-1.2
Total locomotion distance, hab. session 2	0.6	0.8	1.4	1.0	-0.0	-1.1	-0.6	-1.2	-0.9
Locomotion velocity, hab. session 2	0.6	0.8	1.5	0.9	0.0	-1.2	-0.7	-1.1	-0.8
Novel to familiar place preference ratio	1.0	1.0	1.5	0.8	1.1	1.2	-1.0	-0.5	1.2
Novelty place preference	0.6	0.6	1.1	0.6	0.8	1.0	-0.7	-0.4	1.1
Time in novel zone, NPP test	0.4	0.4	0.9	0.4	0.6	0.9	-0.5	-0.2	1.0
Total zone transitions, NPP test	0.3	0.4	1.3	1.2	0.2	-0.5	-0.5	-0.5	0.2
Total locomotion distance, NPP test	0.7	0.9	2.4	1.6	1.1	0.3	-0.8	-0.6	0.9
Locomotion velocity, NPP test	1.0	1.5	3.6	1.9	1.3	0.3	-1.2	-1.0	0.9
Intraocular pressure	0.0	0.1	0.1	0.2	0.1	-0.3	0.3	0.2	-0.1
Delta distance traveled before/after self-admin	0.0	0.0	0.2	-0.1	-0.2	0.5	-0.1	-0.0	0.1
Delta ambulatory time before/after self-admin	0.2	0.2	0.4	-0.4	-0.6	-0.2	0.3	0.2	-0.6
Parametrial fat weight	0.2	0.3	1.2	-0.2	-0.7	-0.2	0.1	-0.4	-1.1
Pavlov. Cond. lever latency	0.8	1.0	2.3	1.1	0.7	1.0	-1.1	-1.5	-0.3
Pavlov. Cond. magazine entry latency	2.1	2.6	3.5	-1.9	-1.9	-1.7	1.7	1.7	-0.6
Pavlov. Cond. change in total contacts	0.6	0.6	1.1	-0.8	-0.9	-0.4	1.0	1.1	-0.3
Pavlov. Cond. index score	1.5	1.9	3.3	-1.5	-1.3	-1.4	1.5	1.8	-0.1
Pavlov. Cond. latency score	1.4	1.8	3.1	-1.6	-1.2	-1.4	1.4	1.8	-0.1
Pavlov. Cond. lever contacts	0.8	1.0	2.5	-1.0	-0.7	-0.7	1.1	1.6	0.5
Pavlov. Cond. magazine entry number	1.0	1.3	1.9	1.1	1.3	1.4	-1.2	-1.1	0.6
Pavlov. Cond. intertrial magazine entries	2.6	3.2	4.7	1.7	2.2	1.8	-1.7	-1.5	1.7
Pavlov. Cond. lever-magazine prob. diff.	1.3	1.6	3.0	-1.4	-1.1	-1.1	1.4	1.7	0.1
Pavlov. Cond. response bias	1.8	2.2	3.4	-1.6	-1.5	-1.4	1.7	1.9	-0.1
Pavlov. Cond. lever latency	0.8	1.1	2.6	-0.4	-1.3	-0.6	1.2	0.7	-1.6
Pavlov. Cond. magazine entry latency	0.7	0.8	2.0	-1.3	-0.5	-0.2	0.8	1.4	0.3
Pavlov. Cond. change in total contacts	0.7	0.9	1.9	0.1	1.0	0.8	-1.3	-0.7	1.4
Pavlov. Cond. index score	0.2	0.3	1.1	-0.4	0.5	0.3	-0.3	0.3	1.1
Pavlov. Cond. latency score	0.2	0.3	1.0	-0.5	0.4	0.2	-0.3	0.3	1.0
Pavlov. Cond. lever contacts	1.7	2.3	3.3	1.1	1.8	1.2	-1.8	-1.3	1.7
Pavlov. Cond. magazine entry number	0.1	0.2	0.3	0.5	-0.2	-0.3	-0.1	-0.5	-0.5
Pavlov. Cond. intertrial magazine entries	3.3	4.3	8.1	-1.8	-2.2	-2.8	1.6	0.9	-2.5
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	1.2	-0.4	0.6	0.4	-0.4	0.2	1.1
Pavlov. Cond. response bias	0.6	0.8	2.0	0.2	1.2	0.6	-1.0	-0.4	1.4
Time in closed arm before self-admin	0.1	0.1	0.3	0.3	0.5	0.3	-0.0	0.4	0.4
Time in closed arm after self-admin	1.1	1.2	2.1	0.9	1.2	1.3	-0.9	-0.4	1.4
Time in open arm before self-admin	0.4	0.4	1.1	-1.0	-1.0	-0.5	0.5	0.4	0.1
Time in open arm after self-admin	0.7	0.7	1.1	-1.0	-1.0	-0.8	0.8	0.9	-0.4
Bone: periosteal estimation	2.6	5.4	7.1	-2.3	-2.6	-1.7	2.7	2.2	-2.3
Bone: periosteal perimeter	1.2	2.1	2.6	-1.5	-1.6	-1.1	1.6	1.3	-1.5
Bone: post-yield work	1.5	2.1	3.5	-1.1	-1.5	-1.1	1.8	1.9	-1.1
Progressive ratio test 1 active lever presses	0.9	1.0	2.8	0.4	0.9	1.3	-0.3	0.6	1.7
Progressive ratio test 1 breakpoint	1.0	1.1	2.8	0.6	1.0	1.4	-0.5	0.3	1.7
Progressive ratio test 1 inactive lever presses	0.8	0.9	1.2	1.1	1.0	1.1	-1.0	-0.8	0.5
Progressive ratio test 2 active lever presses	0.1	0.2	0.3	0.3	0.5	0.5	-0.3	0.1	0.5
Progressive ratio test 2 breakpoint	0.3	0.3	0.5	0.5	0.7	0.6	-0.6	-0.2	0.6
Progressive ratio test 2 inactive lever presses	0.5	0.6	1.4	-1.1	-0.6	-0.2	0.9	1.2	0.2
Incentive Sensitization - Responses	0.2	0.2	0.7	-0.1	-0.5	-0.7	0.1	-0.3	-0.8
Incentive Sensitization - Breakpoint	0.3	0.4	1.0	-0.2	-0.6	-0.8	0.1	-0.3	-1.0
Sum of active levers in priming session hrs 5-6	0.3	0.3	1.4	0.0	0.4	0.6	-0.2	0.2	1.2
Progressive ratio	0.4	0.4	2.0	0.1	-0.0	0.0	-0.0	-0.7	-1.4
Food seeking constrained by brief footshock	0.8	1.0	2.6	0.8	0.8	1.6	-0.9	-0.3	1.1
Seeking ratio, punishment vs. effort	0.5	0.6	2.3	0.4	0.3	0.7	-0.5	0.1	1.5
Retroperitoneal fat weight	0.1	0.5	1.1	0.3	0.8	1.1	-0.5	-0.2	0.9
Reaction time number correct	1.2	1.8	2.8	1.7	1.4	1.3	-1.4	-1.5	0.1
Reaction time mean minus median	7.2	9.6	13.7	-3.7	-3.2	-2.8	3.4	3.3	-1.8
Reaction time mean minus median AUC	5.1	6.6	11.8	-3.4	-2.2	-1.9	2.9	3.3	-0.5
Reaction time num false alarms	1.0	1.4	3.5	-1.1	-1.0	-1.9	0.7	0.2	-1.4
Reaction time num false alarms AUC	1.2	1.7	4.2	-1.1	-1.2	-2.1	0.7	0.1	-1.7
Reaction time trials correct on left	1.2	1.8	2.8	1.7	1.4	1.3	-1.4	-1.5	0.1
Reaction time trials on left	1.1	1.6	2.5	1.6	1.3	1.3	-1.3	-1.4	0.1
Reaction time mean	4.1	5.8	9.9	-2.6	-2.3	-1.8	2.9	3.1	-1.1
Reaction time mean AUC	4.1	5.6	10.2	-2.6	-2.2	-1.6	2.9	3.2	-1.0
Median of all reaction times	2.1	2.9	5.6	-1.7	-1.5	-1.2	2.1	2.4	-0.9
Reaction time omissions	3.1	4.3	5.3	-1.8	-2.2	-2.1	2.3	2.0	-1.9
Reaction time false alarm rate	1.9	2.7	5.6	-1.9	-1.7	-2.4	1.3	0.9	-1.3
Reaction time premature initiation rate	0.0	0.0	0.1	0.2	-0.0	0.3	-0.1	-0.2	0.2
Reaction time premature initiations	0.5	0.7	1.1	1.0	0.7	1.1	-0.8	-1.0	0.3
Std. dev. reaction times	7.3	10.2	14.3	-3.8	-3.3	-2.7	3.6	3.6	-1.7
Reaction time trials completed	1.1	1.6	2.5	1.6	1.3	1.3	-1.3	-1.4	0.1
Reaction time trials AUC	1.1	1.6	2.6	1.6	1.3	1.2	-1.3	-1.4	0.1
Run reversals in cocaine runway, females	2.8	2.7	4.7	1.1	1.8	2.1	-1.5	-0.6	2.2
Run reversals in cocaine runway, males	3.5	3.4	4.3	-1.9	-2.0	-1.9	2.1	1.8	-1.2
Latency to leave start box in cocaine runway	0.1	0.1	0.2	0.5	0.4	0.3	-0.2	-0.1	0.2
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	0.4	0.4	-0.1	-0.2	0.0	-0.0
Latency to leave start box in cocaine runway, M	0.3	0.3	0.5	0.7	0.5	0.6	-0.4	-0.7	0.3
Std. dev. time between licks in bursts	4.1	4.9	9.1	-2.3	-2.0	-3.0	2.0	2.1	-1.5
Total sessions with >9 infusions	0.5	0.6	1.8	0.1	0.6	0.7	-0.0	0.8	1.3
Short access day 1 total inactive lever presses	1.2	1.4	3.2	-1.4	-1.0	-0.3	1.4	1.8	0.4
Short access day 10 total inactive lever presses	3.1	3.4	9.6	-0.8	-1.9	-2.2	0.7	-0.9	-3.1
Short access day 1 total infusions	0.7	0.8	2.7	0.0	0.4	0.9	0.1	1.0	1.7
Short access day 10 total infusions	0.1	0.1	0.1	0.1	0.2	0.3	-0.3	0.1	0.3
Short access total infusions	0.7	0.8	2.4	0.3	0.7	1.1	-0.3	0.6	1.5
Short access day 1 locomotion	0.0	0.1	0.1	0.3	0.0	-0.3	-0.2	-0.2	-0.1
Short access day 10 total locomotion	2.7	3.0	4.5	-1.7	-2.1	-1.9	1.7	1.0	-1.7
Short access total locomotion	0.3	0.3	0.4	-0.6	-0.6	-0.6	0.6	0.5	-0.4
One hour access (0.3 mA shock)	0.2	0.3	0.7	-0.3	-0.5	-0.9	0.5	0.4	-0.4
Compulsive drug intake	0.2	0.2	0.6	-0.1	-0.3	-0.8	0.3	0.1	-0.5
One hour access (shock baseline)	0.7	0.8	1.8	-1.1	-0.7	-0.2	1.1	1.3	0.2
Social response proportion	0.3	0.3	0.5	-0.6	-0.5	-0.7	0.6	0.4	-0.4
Social responses	0.6	0.8	1.7	-0.6	-0.9	-1.2	0.5	-0.1	-1.3
Social time	8.0	10.6	16.0	-2.6	-3.7	-4.0	2.9	1.7	-4.0
Soleus weight	6.8	19.9	25.5	-5.0	-4.8	-4.4	4.9	4.5	-2.7
Bone: stiffness	0.2	0.3	1.0	1.0	0.4	0.0	-0.3	-0.5	-0.7
Tibialis anterior weight	0.2	0.7	1.5	1.2	0.5	-0.1	-1.1	-1.1	0.4
Time to tail flick, vehicle, before self-admin	2.0	2.0	6.1	-0.6	-1.1	-2.0	0.6	-0.3	-2.5
Time to tail flick, vehicle, after self-admin	1.1	1.1	1.7	-0.9	-1.2	-1.1	1.0	0.8	-1.3
Time to tail flick, test, before self-admin	0.5	0.5	1.8	0.6	0.1	-0.3	-0.7	-1.3	-0.6
Time to tail flick, test, after self-admin	0.5	0.5	1.1	-0.7	-1.0	-1.0	0.4	0.3	-0.6
Delta time to tail flick, vehicle, before/after SA	1.5	1.5	3.8	0.7	1.1	1.7	-0.7	0.3	1.9
Delta time to tail flick, test, before/after SA	0.1	0.1	0.1	0.3	0.3	0.4	-0.2	0.2	0.3
Tibia length	4.0	11.4	14.3	-3.3	-3.8	-2.7	3.7	2.9	-3.7
Ambulatory time before self-admin	0.9	0.9	1.6	-0.8	-1.1	-1.1	0.7	0.3	-1.3
Ambulatory time after self-admin	1.6	1.8	3.4	-1.2	-1.7	-1.5	1.0	0.3	-1.9
Bone: tissue strength	0.6	0.6	1.8	0.9	0.6	1.3	0.1	0.4	0.6
Total heroin consumption	0.2	0.2	0.5	-0.5	-0.7	-0.6	0.1	0.0	-0.6
Bone: trabecular number	0.4	0.7	1.1	1.0	0.9	0.1	-1.0	-0.9	0.6
Bone: trabecular spacing	0.4	0.5	1.1	-1.1	-0.8	0.3	0.7	0.7	-0.4
Bone: trabecular thickness	0.0	0.1	0.1	0.2	0.3	-0.3	0.1	0.2	0.1
Bone: trabecular tissue density	0.3	0.4	0.8	-0.9	-0.7	-0.1	0.6	0.8	0.2
Water consumed over 24 hours	0.3	0.4	0.9	0.0	-1.0	-0.0	1.0	0.7	-0.3
Number of responses in last shaping day	1.1	1.1	3.3	-0.6	-0.1	0.7	0.6	1.5	1.8