Hub : Genes

Nudt3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc mRNA stability Nudt3 0.07 0.03 1.5e-04 0.03 0.03 0.02 0.03 7.5e-05 6.5e-05 1.5e-03 8.6e-05
2 Brain gene expression Nudt3 0.24 0.08 5.6e-17 0.19 0.16 0.18 0.2 4.5e-17 2.4e-14 5.8e-17 3.5e-18
3 IC gene expression Nudt3 0.5 0.14 2.9e-11 0.16 0.29 0.18 0.27 2.8e-07 1.4e-12 4.5e-08 1.2e-11
4 NAcc gene expression Nudt3 0.2 0.07 9.4e-16 0.09 0.12 0.12 0.12 2.2e-13 3.0e-18 2.7e-17 1.9e-17
5 IL gene expression Nudt3 0.35 0.25 8.0e-03 0.04 0.02 0.1 0.12 4.9e-02 1.2e-01 2.7e-03 6.5e-04
6 PL gene expression Nudt3 0.21 0.07 5.3e-13 0.12 0.12 0.11 0.11 1.1e-12 3.1e-13 3.3e-12 1.9e-12
7 pVTA gene expression Nudt3 0.28 0.09 1.2e-15 0.13 0.23 0.23 0.23 8.6e-11 3.1e-18 1.6e-18 1.7e-18
8 Adipose gene expression Nudt3 0.07 0.05 1.5e-03 -0 0.01 0.01 0 6.2e-01 1.9e-02 1.0e-02 3.6e-01
9 Brain mRNA stability Nudt3 0.09 0.04 6.6e-07 0.07 0.06 0.07 0.08 1.6e-07 2.4e-06 2.1e-07 3.4e-08
10 Liver gene expression Nudt3 0.17 0.07 1.4e-07 0.02 0.05 0.05 0.04 6.0e-03 4.3e-06 2.6e-06 8.8e-06
11 BLA gene expression Nudt3 0.3 0.1 1.6e-07 0.1 0.1 0.11 0.1 3.6e-06 4.4e-06 2.0e-06 3.3e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.30.41.2-1.1-0.6-1.0-0.80.2-0.8-0.30.1-0.5-0.30.6
Area under the delay curve0.20.20.70.50.3-0.3-0.20.1-0.2-0.5-0.60.90.80.2
BMI with tail1.03.68.3-2.0-1.8-1.8-1.7-2.9-1.5-1.7-2.6-1.7-1.5-1.0
BMI without tail0.41.24.4-0.5-0.5-0.5-0.5-1.6-0.5-0.7-2.1-0.5-1.2-1.7
Body weight0.94.09.43.12.42.22.1-0.52.21.2-0.42.62.21.0
Weight adjusted by age1.52.25.82.41.61.61.1-0.31.40.4-0.12.42.0-0.4
Bone surface0.91.62.31.01.21.21.31.21.31.51.50.90.81.5
Bone volume0.10.21.00.10.40.20.30.60.20.40.60.30.21.0
Breakpoint value in progressive ratio session0.20.20.9-0.30.20.10.70.70.10.60.0-0.4-0.31.0
Number of licking bursts1.01.62.60.81.11.41.41.51.41.61.60.80.90.8
Context. condit. distance diff. score3.03.67.21.11.81.51.42.71.51.62.61.32.02.6
Locomotion velocity, session 10.50.62.00.70.70.50.21.40.20.60.81.10.8-0.1
Locomotion distance, session 10.50.71.5-1.1-1.1-0.7-0.9-0.1-0.7-0.20.6-1.2-1.0-0.6
Locomotion velocity, session 20.80.92.30.70.71.01.01.21.01.21.50.20.40.9
Locomotion distance, session 20.10.20.4-0.5-0.6-0.4-0.6-0.1-0.3-0.20.6-0.6-0.20.5
Locomotion velocity, session 30.20.20.7-0.4-0.5-0.2-0.10.2-0.30.00.2-0.8-0.8-0.8
Locomotion distance, session 30.40.51.1-1.0-0.7-0.7-0.80.5-0.8-0.30.3-0.9-0.5-0.5
Stereotopy head waving bouts, day 33.23.75.62.42.12.32.31.12.32.01.31.71.81.5
Stereotopy head waving duration, day 31.01.22.81.71.11.31.30.51.20.90.61.20.90.3
Locomotion velocity, session 70.60.61.6-0.9-0.3-1.1-1.20.2-1.0-1.00.20.10.41.0
Locomotion distance, session 70.70.92.0-1.1-0.7-1.3-1.40.7-1.4-1.30.1-0.2-0.10.2
Stereotopy head waving bouts, day 70.30.32.50.0-0.2-0.1-0.10.5-0.40.0-0.50.0-0.5-1.6
Stereotopy head waving duration, day 70.10.21.10.30.20.20.30.20.00.4-0.40.1-0.2-1.1
Locomotion velocity, session 85.86.98.92.72.72.62.63.02.62.52.82.22.52.6
Locomotion distance, session 81.52.16.80.50.91.00.81.81.11.22.60.31.32.5
Degree of sensitization distance1.11.22.51.21.11.01.10.71.10.50.81.31.11.6
Degree of sensitization stereotypy0.80.93.5-1.0-0.9-0.8-0.80.4-1.1-0.4-0.6-0.8-1.1-1.9
Conditioned locomotion0.80.93.00.90.81.01.0-0.01.10.60.90.60.81.7
Cocaine response after cond. corrected0.20.21.2-0.50.00.10.1-0.70.40.30.3-0.60.01.1
Cocaine response after cond. not corrected0.81.02.00.81.01.31.20.11.41.21.00.40.61.0
Cocaine response before conditioning2.63.16.72.61.92.22.01.42.01.51.22.11.3-0.2
Saline control response2.12.86.1-0.9-1.4-1.2-1.3-2.5-1.4-1.4-2.4-1.1-1.7-2.3
Bone: connectivity density0.20.31.9-0.30.3-0.1-0.10.50.10.30.70.20.41.4
Bone: cortical apparent density1.01.43.8-1.1-1.3-1.1-1.0-1.9-0.8-0.7-1.0-1.4-1.2-0.7
Bone: cortical area0.00.10.20.10.30.30.20.20.30.40.10.3-0.1-0.2
Bone: cortical porosity1.21.25.1-0.3-0.8-0.9-1.00.4-1.4-1.4-1.00.2-1.0-2.3
Bone: cortical porosity0.60.72.60.40.1-0.3-0.50.9-0.8-1.0-0.71.2-0.0-1.6
Bone: cortical thickness3.15.27.1-2.7-2.5-2.4-2.4-2.0-2.2-1.7-1.7-2.3-2.6-2.4
Bone: cortical thickness3.74.46.1-2.3-2.4-2.1-1.9-2.5-1.8-1.7-1.6-2.4-2.4-1.5
Bone: cortical tissue density0.71.03.2-0.8-1.1-0.9-0.8-1.8-0.6-0.6-0.8-1.2-1.0-0.6
Condit. Reinf. active minus inactive responses0.20.30.90.1-0.2-0.4-0.60.3-0.6-0.6-0.60.40.0-1.0
Condit. Reinf. active-inactive response ratio0.30.31.1-0.1-0.4-0.3-0.4-0.6-0.5-0.5-1.0-0.1-0.4-1.0
Condit. Reinf. active responses0.20.30.7-0.2-0.2-0.5-0.80.0-0.7-0.8-0.80.30.1-0.5
Condit. Reinf. inactive responses0.50.61.4-1.1-0.7-1.0-1.2-0.0-1.0-1.0-0.6-0.3-0.2-0.1
Incentive salience index mean0.40.51.70.50.70.40.21.30.20.20.51.00.90.4
Condit. Reinf. lever presses1.42.04.00.71.51.10.92.01.01.11.61.31.72.0
Condit. Reinf. active minus inactive responses0.20.31.11.00.30.60.60.30.50.10.20.70.2-0.5
Condit. Reinf. active-inactive response ratio0.60.61.71.30.81.00.90.50.90.40.21.00.7-0.2
Condit. Reinf. active responses0.10.10.40.6-0.10.30.30.20.2-0.10.40.3-0.1-0.3
Condit. Reinf. inactive responses0.10.20.5-0.3-0.7-0.4-0.3-0.4-0.3-0.30.2-0.7-0.7-0.1
Condit. Reinf. lever presses0.40.52.2-0.4-0.7-0.6-0.90.3-0.9-0.9-0.1-0.0-0.7-1.5
Condit. Reinf. lever reinforcers received0.10.10.40.5-0.10.30.10.30.1-0.10.40.3-0.2-0.6
Conditioned reinforcement - actives0.10.20.50.0-0.1-0.7-0.6-0.2-0.4-0.5-0.10.50.60.6
Conditioned reinforcement - inactives0.30.41.7-0.0-0.5-0.4-0.6-0.7-0.5-0.8-0.80.4-0.3-1.3
Conditioned locomotion0.40.62.40.70.6-0.1-0.40.2-0.1-0.6-0.41.61.50.3
Patch foraging indifference point 0 sec1.12.15.4-0.9-1.5-1.2-1.2-2.3-1.0-1.3-1.8-1.1-1.3-1.7
Patch foraging indifference point AUC1.72.43.61.81.61.91.71.71.81.91.71.00.80.2
Delay disc. indifference point, 0s delay0.30.30.90.50.60.20.10.50.30.10.10.71.00.9
Delay disc. indifference point, 16s delay1.11.22.2-0.8-1.2-1.3-1.3-1.1-1.2-1.5-1.3-0.2-0.7-1.0
Delay disc. indifference point, 2s delay0.70.82.91.31.10.50.40.60.40.10.11.71.50.4
Delay disc. indifference point, 24s delay1.21.43.9-0.2-0.9-1.1-1.2-1.1-1.2-1.7-2.00.6-0.0-1.5
Delay disc. indifference point, 4s delay0.80.81.71.31.20.80.80.70.80.70.20.91.30.8
Delay disc. indifference point, 8s delay0.20.30.80.30.2-0.4-0.40.1-0.5-0.7-0.90.90.6-0.1
Indifference point function ln k0.00.10.2-0.4-0.1-0.20.00.5-0.2-0.00.4-0.3-0.20.2
Indifference point function log k0.00.10.2-0.4-0.1-0.20.00.5-0.2-0.00.4-0.3-0.20.2
Patch foraging total patch changes 0 sec1.52.86.5-1.2-1.8-1.4-1.4-2.6-1.3-1.5-2.0-1.2-1.6-2.0
Patch foraging total patch changes 12 sec0.50.61.8-0.3-0.8-0.4-0.3-1.1-0.1-0.1-0.3-1.0-1.2-1.3
Patch foraging total patch changes 18 sec1.62.46.5-1.5-1.8-1.3-1.4-2.5-1.0-1.1-1.2-1.8-1.7-1.1
Patch foraging total patch changes 24 sec2.64.46.5-2.2-2.5-2.1-2.4-2.6-2.0-1.9-1.7-1.7-2.0-1.8
Patch foraging total patch changes 6 sec2.53.86.7-1.6-2.1-1.8-2.0-2.6-1.7-1.9-2.1-1.5-1.8-2.2
Patch foraging time to switch 0 sec1.42.97.2-1.8-1.8-1.7-1.5-2.7-1.4-1.7-1.8-1.7-1.40.1
Patch foraging water rate 0 sec0.10.20.60.60.40.30.00.00.50.20.20.80.6-0.4
Patch foraging water rate 12 sec0.61.32.3-1.5-1.5-1.3-1.3-0.8-1.2-0.8-0.2-1.4-1.3-0.7
Patch foraging water rate 18 sec0.10.20.80.20.4-0.1-0.3-0.0-0.1-0.3-0.50.90.6-0.3
Patch foraging water rate 24 sec0.10.10.7-0.4-0.4-0.4-0.20.0-0.10.10.3-0.9-0.30.2
Patch foraging water rate 6 sec0.20.20.7-0.6-0.7-0.3-0.4-0.3-0.20.00.4-0.8-0.7-0.1
Seeking ratio, delayed vs. immediate footshock0.50.61.40.40.30.71.10.50.71.20.9-0.9-0.60.7
Distance traveled before self-admin1.31.73.21.01.11.41.70.41.61.71.40.20.61.8
Distance traveled after self-admin1.72.14.51.51.31.72.10.41.71.81.40.30.51.5
Extensor digitorum longus weight0.93.74.82.12.02.01.91.72.02.02.21.61.91.9
Bone: elastic displacement1.72.04.8-0.9-1.3-1.5-1.7-0.8-1.7-1.6-1.4-0.4-1.1-2.2
Bone: elastic work0.70.91.8-0.6-0.8-1.1-1.2-0.7-1.2-1.1-1.2-0.0-0.6-1.3
Bone: endosteal estimation6.414.020.94.64.44.44.22.54.13.31.94.03.83.0
Bone: endosteal perimeter4.18.611.93.13.43.43.32.43.22.82.02.72.92.9
Epididymis fat weight11.539.560.1-6.9-7.0-6.5-6.4-7.8-5.7-5.6-6.1-6.2-6.1-4.3
Delta time in closed arm before/after self-admin1.21.22.3-0.9-0.8-1.2-1.1-1.3-1.2-1.5-1.5-0.4-0.8-0.7
Delta time in open arm before/after self-admin1.11.01.91.11.21.01.01.40.91.00.80.81.30.7
Diff in mean of infusions in LGA sessions0.30.41.2-1.1-0.6-0.5-0.40.1-0.4-0.20.0-0.8-0.51.0
Delay discount exponential model param0.20.20.7-0.5-0.20.30.2-0.10.30.50.6-0.9-0.8-0.1
Extinction: sum of active levers before priming0.10.10.2-0.5-0.3-0.10.1-0.10.00.30.2-0.5-0.30.1
Active lever presses in extinction session 62.02.04.4-1.1-1.0-1.5-1.6-0.9-1.7-2.0-2.10.1-0.7-1.6
Bone: final force0.50.83.9-0.4-0.7-0.6-0.4-2.0-0.3-0.7-1.5-0.6-0.6-0.2
Bone: final moment0.30.52.1-0.2-0.4-0.4-0.3-1.4-0.3-0.6-1.5-0.1-0.2-0.2
Food consumed during 24 hour testing period0.40.61.50.70.80.90.9-0.50.90.50.10.40.61.2
Glucose4.46.911.12.93.12.72.23.02.41.91.83.33.21.5
Heart weight0.60.95.10.7-0.1-0.1-0.7-0.9-0.3-1.0-0.91.10.1-2.3
Delay discount hyperbolic model param0.20.20.8-0.6-0.30.20.1-0.20.20.40.4-0.9-0.70.0
Intermittent access intake day 1-15 change0.10.20.70.00.20.20.60.20.30.60.1-0.5-0.20.8
Intermittent access intake escalation0.10.10.3-0.2-0.3-0.30.2-0.2-0.30.0-0.4-0.6-0.50.3
Intermittent access intake escalation 20.91.11.71.11.20.91.11.30.71.00.61.01.11.0
Intermitt. access day 1 inactive lever presses0.41.53.40.20.81.21.50.91.41.81.8-1.1-0.61.0
Intermitt. access day 15 inactive lever presses0.30.71.41.00.91.11.20.21.11.00.70.30.40.5
Intermitt. access escalation Index0.81.13.5-0.80.10.20.40.90.41.21.6-1.6-0.51.9
Intermittent access day 1 total infusions0.61.02.0-0.2-0.5-1.2-1.4-0.1-1.1-1.4-0.91.30.6-1.0
Intermittent access day 15 total infusions0.30.40.7-0.3-0.6-0.9-0.8-0.4-0.8-0.8-0.80.4-0.1-0.7
Intermittent access terminal intake (last 3 days)0.50.61.2-0.2-0.7-0.9-0.9-0.7-0.9-1.1-1.00.5-0.1-1.1
Intermittent access total infusions0.50.61.2-0.0-0.4-0.8-0.9-0.3-0.8-1.0-0.91.00.3-1.1
Intermittent access day 1 locomotion0.10.10.50.30.1-0.2-0.4-0.2-0.0-0.20.10.60.70.5
Intermittent access day 15 total locomotion0.30.61.61.20.90.50.5-0.20.50.1-0.51.31.20.7
Intermittent access total locomotion0.50.62.11.10.70.40.2-0.10.40.1-0.11.41.40.4
Intermittent access standard deviation0.20.52.70.0-0.5-0.10.2-1.70.1-0.3-0.9-0.6-0.9-0.5
Left kidney weight0.20.93.01.70.71.11.2-0.91.20.6-0.21.00.80.3
Right kidney weight0.62.66.02.41.71.81.9-0.31.91.20.11.71.71.5
Cocaine induced anxiety1.72.44.51.11.61.71.71.01.72.12.0-0.00.91.7
Post-drug Anxiety0.70.71.60.60.81.11.0-0.01.21.20.9-0.10.50.8
Baseline Anxiety2.32.74.7-1.6-1.8-1.7-1.7-2.2-1.5-1.9-2.1-0.8-1.1-0.9
Tail length4.015.728.95.44.74.84.53.34.23.72.44.13.41.5
Length with tail5.323.245.16.75.65.55.13.15.14.02.85.54.92.7
Length without tail2.68.216.64.13.33.02.60.43.21.81.23.63.72.5
Times rat made contact with spout3.13.65.1-2.0-2.0-2.2-2.1-1.2-2.3-1.8-1.5-1.5-1.9-2.0
Lifetime Intake0.50.61.10.1-0.3-0.7-0.9-0.3-0.7-1.1-1.01.10.3-1.1
Liver weight, left5.69.313.33.43.73.53.32.13.43.12.12.83.12.8
Liver weight, right10.318.125.15.04.84.94.63.44.64.23.33.84.23.4
Locomotor activity1.01.63.91.21.21.71.80.81.52.01.20.30.40.2
Locomotor testing distance0.20.31.1-0.20.10.50.7-0.40.61.00.5-0.9-0.40.5
Locomotor testing rearing0.51.02.80.60.81.01.3-0.11.31.30.8-0.20.51.7
Locomotion in novel chamber0.00.10.50.10.1-0.20.10.7-0.00.20.10.10.20.1
Locomotion in novel chamber post-restriction0.20.31.1-0.3-0.3-0.5-0.5-1.0-0.4-0.6-1.0-0.3-0.30.3
Fecal boli incidents, locomotor time 10.20.30.6-0.2-0.0-0.6-0.5-0.2-0.5-0.6-0.60.70.80.4
Change in fecal boli incidents, locomotor task0.30.30.70.50.50.80.7-0.40.80.40.2-0.2-0.1-0.0
Time >=10cm from walls, locomotor time 11.81.93.41.11.81.71.80.41.81.60.70.21.11.4
Bouts of movement, locomotor time 10.91.01.90.40.90.91.21.30.81.41.30.10.31.3
Total resting periods, locomotor time 11.31.42.20.81.31.21.31.41.11.51.40.50.71.4
Rest time, locomotor task time 10.60.81.80.91.00.50.41.30.60.71.20.91.10.8
Distance moved, locomotor task time 10.20.31.6-0.2-0.4-0.1-0.0-1.3-0.1-0.4-1.0-0.5-0.7-0.6
Vertical activity count, locomotor time 10.20.42.40.1-0.10.10.3-1.50.1-0.3-1.3-0.5-0.6-0.3
Time >=10cm from walls, locomotor time 20.40.61.60.80.90.50.4-0.70.5-0.2-1.30.81.30.2
Bouts of movement, locomotor time 22.13.35.41.92.12.12.32.11.72.31.70.81.11.3
Total resting periods, locomotor time 22.44.16.62.12.22.32.42.61.92.62.10.91.21.3
Rest time, locomotor task time 23.44.36.71.62.12.12.12.22.22.52.60.61.82.2
Distance moved, locomotor task time 22.63.17.6-0.9-1.4-1.5-1.7-2.7-1.5-2.4-2.80.2-0.7-1.5
Vertical activity count, locomotor time 21.21.64.7-0.3-0.8-1.1-1.2-2.2-1.0-1.8-2.10.4-0.2-0.8
Light reinforcement 10.40.92.6-0.6-0.20.10.5-1.60.60.90.3-1.6-0.81.6
Light reinforcement 20.60.94.20.70.80.71.0-0.41.10.90.5-0.00.52.1
Bone: marrow area6.413.920.94.64.44.34.22.44.13.31.84.03.83.0
Bone: maximum diameter3.46.38.52.62.92.72.62.52.52.52.12.52.32.1
Bone: maximum force0.10.10.50.30.10.10.1-0.70.3-0.0-0.60.30.20.2
Bone: maximum moment0.10.20.80.60.50.20.2-0.20.30.0-0.60.90.60.1
Mean time between licks in bursts2.76.713.42.62.22.82.72.82.72.63.71.52.02.4
Mean num. licks in bursts2.74.25.8-1.7-2.1-2.4-2.3-1.9-2.4-2.2-2.1-1.4-1.8-1.9
Cd content in liver1.01.12.6-0.6-0.7-1.3-1.4-1.6-0.9-1.6-1.3-0.10.20.4
Co content in liver2.02.36.3-1.2-1.3-1.5-1.6-2.5-1.2-1.8-2.2-0.5-0.7-0.8
Cu content in liver3.64.36.7-2.6-2.5-2.3-2.1-1.3-2.2-1.6-1.4-2.1-2.2-1.8
Fe content in liver0.20.20.6-0.1-0.7-0.4-0.3-0.7-0.3-0.5-0.4-0.5-0.30.2
K content in liver0.20.21.70.1-0.10.2-0.00.80.10.11.30.10.00.4
Mg content in liver2.32.47.31.21.31.71.41.61.61.62.70.70.91.5
Mn content in liver7.68.412.13.02.73.13.02.43.22.73.52.02.73.1
Na content in liver0.70.72.2-1.0-1.1-0.7-0.5-0.2-0.7-0.30.2-1.2-1.5-0.8
Rb content in liver0.30.31.10.20.50.2-0.10.20.20.20.20.81.01.0
Se content in liver4.25.07.92.52.02.62.42.72.32.42.81.61.61.0
Sr content in liver0.40.30.90.20.2-0.3-0.5-0.5-0.3-0.7-0.90.90.70.1
Zn content in liver0.70.81.51.20.80.90.70.71.00.51.10.91.00.9
Bone: minimum diameter2.64.77.02.42.62.52.31.62.41.91.42.22.22.0
Time in familiar zone, hab. session 12.62.54.4-1.8-1.7-2.0-2.0-0.4-2.1-1.8-1.2-1.2-1.2-1.2
Time in novel zone, hab. session 11.41.42.51.41.31.51.40.31.61.40.81.01.00.8
Total zone transitions, hab. session 10.50.71.8-1.2-1.0-0.6-0.7-0.2-0.50.10.5-1.3-1.2-0.9
Total locomotion distance, hab. session 10.50.72.1-1.0-0.9-0.3-0.40.0-0.30.21.0-1.4-1.2-0.5
Locomotion velocity, hab. session 10.50.72.1-0.9-1.0-0.4-0.4-0.1-0.30.01.0-1.4-1.3-0.7
Time in familiar zone, hab. session 20.60.61.7-0.1-0.30.50.90.10.61.11.3-1.2-0.70.5
Time in novel zone, hab. session 20.80.82.60.30.5-0.5-0.9-0.3-0.7-1.1-1.61.40.8-0.5
Total zone transitions, hab. session 20.40.51.5-0.5-0.40.30.4-0.20.51.01.2-1.2-0.60.5
Total locomotion distance, hab. session 20.70.93.5-1.1-0.70.00.10.00.30.91.7-1.9-1.00.5
Locomotion velocity, hab. session 20.71.03.5-1.0-0.70.10.20.20.30.91.9-1.8-1.00.5
Novel to familiar place preference ratio0.91.01.8-1.0-0.9-1.2-1.2-0.6-1.2-1.1-1.3-0.3-0.7-1.1
Novelty place preference0.60.71.3-0.7-0.7-0.9-1.0-0.5-0.9-0.9-1.1-0.2-0.5-1.0
Time in novel zone, NPP test0.40.41.1-0.4-0.5-0.8-0.8-0.3-0.8-0.7-1.00.0-0.3-0.9
Total zone transitions, NPP test0.20.31.4-0.7-0.5-0.1-0.30.4-0.10.31.2-0.9-0.50.2
Total locomotion distance, NPP test0.50.71.5-1.2-0.9-0.9-1.1-0.4-0.8-0.70.2-1.1-0.50.2
Locomotion velocity, NPP test0.81.12.8-1.7-1.3-1.1-1.3-0.5-1.0-0.70.3-1.6-1.0-0.2
Intraocular pressure0.10.11.20.00.0-0.1-0.1-0.30.00.10.20.10.51.1
Delta distance traveled before/after self-admin0.20.20.70.70.30.20.20.10.0-0.1-0.60.70.1-0.8
Delta ambulatory time before/after self-admin0.20.30.80.90.60.70.70.30.50.50.00.70.4-0.2
Parametrial fat weight0.20.52.70.00.20.20.6-1.30.50.5-0.5-0.30.21.7
Pavlov. Cond. lever latency1.41.78.2-0.9-1.2-0.8-0.5-2.9-0.5-0.7-1.4-1.6-1.4-0.2
Pavlov. Cond. magazine entry latency2.33.09.21.61.81.71.53.01.31.61.81.91.40.2
Pavlov. Cond. change in total contacts1.01.13.21.01.11.00.71.80.60.70.51.61.0-0.4
Pavlov. Cond. index score2.12.69.91.41.71.41.03.11.01.21.62.01.60.3
Pavlov. Cond. latency score2.02.59.81.31.61.31.13.10.91.21.71.91.50.3
Pavlov. Cond. lever contacts1.21.55.70.81.30.80.52.40.60.61.11.61.50.5
Pavlov. Cond. magazine entry number1.52.06.3-1.2-1.4-1.4-1.1-2.5-1.1-1.3-1.6-1.5-1.10.1
Pavlov. Cond. intertrial magazine entries2.83.46.5-1.6-1.9-1.9-2.2-2.6-1.8-2.3-1.8-1.3-1.4-1.1
Pavlov. Cond. lever-magazine prob. diff.1.82.29.21.21.51.20.83.00.81.01.51.81.50.1
Pavlov. Cond. response bias2.53.08.81.61.81.61.33.01.31.51.91.91.70.4
Pavlov. Cond. lever latency0.91.33.10.81.21.21.40.31.41.40.70.51.01.8
Pavlov. Cond. magazine entry latency0.60.72.11.01.10.60.51.10.40.1-0.01.51.20.6
Pavlov. Cond. change in total contacts0.50.72.4-0.4-0.8-0.8-0.9-0.1-1.1-1.0-0.9-0.1-0.9-1.5
Pavlov. Cond. index score0.20.20.50.30.1-0.2-0.40.6-0.5-0.6-0.40.70.2-0.7
Pavlov. Cond. latency score0.10.20.40.20.0-0.2-0.40.5-0.5-0.5-0.40.50.1-0.6
Pavlov. Cond. lever contacts1.01.43.3-0.9-1.2-1.2-1.5-0.5-1.4-1.4-0.8-0.5-1.1-1.8
Pavlov. Cond. magazine entry number0.10.20.5-0.2-0.30.10.2-0.40.20.40.6-0.7-0.5-0.1
Pavlov. Cond. intertrial magazine entries2.43.67.81.41.32.12.41.92.22.52.80.20.71.6
Pavlov. Cond. lever-magazine prob. diff.0.20.20.50.2-0.1-0.3-0.50.5-0.6-0.7-0.40.50.1-0.7
Pavlov. Cond. response bias0.30.41.1-0.1-0.4-0.5-0.90.3-0.8-0.9-0.30.4-0.3-1.1
Time in closed arm before self-admin0.10.10.50.30.20.20.10.20.20.10.10.50.70.3
Time in closed arm after self-admin1.51.73.2-1.1-1.2-1.5-1.7-1.1-1.6-1.8-1.4-0.2-0.6-1.1
Time in open arm before self-admin0.20.21.1-0.1-0.5-0.2-0.10.0-0.4-0.3-0.20.1-0.6-1.0
Time in open arm after self-admin0.91.01.91.21.01.11.21.41.01.11.00.80.90.3
Bone: periosteal estimation2.85.98.62.92.92.92.81.62.72.41.32.62.21.8
Bone: periosteal perimeter1.22.03.21.61.81.71.71.21.61.30.71.51.20.9
Bone: post-yield work3.14.56.72.22.62.11.91.92.11.71.42.22.62.4
Progressive ratio test 1 active lever presses0.50.61.5-0.1-0.3-0.7-0.9-0.7-0.7-1.2-1.20.80.2-0.9
Progressive ratio test 1 breakpoint0.50.61.4-0.1-0.3-0.6-0.9-0.7-0.6-1.2-1.10.80.2-1.0
Progressive ratio test 1 inactive lever presses0.71.12.9-1.0-1.1-1.1-0.9-1.7-0.8-1.0-1.0-0.8-0.9-0.2
Progressive ratio test 2 active lever presses0.20.30.7-0.4-0.3-0.7-0.70.1-0.7-0.8-0.70.3-0.0-0.4
Progressive ratio test 2 breakpoint0.30.30.8-0.4-0.4-0.8-0.80.1-0.7-0.9-0.80.3-0.0-0.4
Progressive ratio test 2 inactive lever presses0.30.41.60.80.90.50.20.70.3-0.10.11.31.00.0
Incentive Sensitization - Responses0.10.21.1-0.20.1-0.10.11.0-0.00.40.7-0.3-0.10.6
Incentive Sensitization - Breakpoint0.20.21.0-0.30.1-0.20.11.0-0.10.40.6-0.4-0.10.7
Sum of active levers in priming session hrs 5-60.10.10.4-0.1-0.1-0.2-0.20.4-0.3-0.3-0.30.20.0-0.6
Progressive ratio0.30.41.90.3-0.30.20.5-1.40.3-0.1-0.7-0.8-0.8-0.6
Food seeking constrained by brief footshock1.21.54.0-0.7-0.8-1.2-1.2-0.5-1.4-1.4-2.00.3-0.4-1.9
Seeking ratio, punishment vs. effort0.40.61.3-0.8-0.4-0.9-1.10.7-1.1-0.7-0.50.4-0.1-0.9
Retroperitoneal fat weight0.00.10.40.10.00.20.1-0.60.20.1-0.30.00.30.6
Reaction time number correct1.01.82.5-1.5-1.6-1.4-1.1-1.4-1.3-1.3-1.5-1.6-1.3-0.8
Reaction time mean minus median3.58.811.63.23.43.12.83.42.72.62.53.13.12.5
Reaction time mean minus median AUC2.46.110.12.82.92.21.93.01.91.51.63.23.22.2
Reaction time num false alarms0.91.23.50.80.81.21.41.11.31.51.9-0.1-0.10.7
Reaction time num false alarms AUC0.91.54.30.90.81.41.51.21.41.62.1-0.0-0.20.3
Reaction time trials correct on left1.01.82.5-1.5-1.6-1.4-1.1-1.4-1.3-1.3-1.5-1.6-1.3-0.8
Reaction time trials on left0.91.62.2-1.4-1.5-1.3-1.0-1.3-1.2-1.3-1.5-1.5-1.2-0.7
Reaction time mean3.65.79.82.52.92.32.02.42.01.61.43.03.12.3
Reaction time mean AUC3.65.710.32.52.92.21.92.51.91.51.13.23.22.4
Median of all reaction times2.12.96.21.72.21.51.31.51.40.90.62.42.51.8
Reaction time omissions3.65.36.81.92.62.42.42.32.32.42.21.72.22.6
Reaction time false alarm rate2.02.76.71.51.51.91.81.81.82.02.60.80.50.5
Reaction time premature initiation rate0.00.10.4-0.1-0.2-0.3-0.1-0.6-0.00.1-0.2-0.1-0.1-0.1
Reaction time premature initiations0.50.92.1-0.9-1.0-1.0-0.8-1.5-0.8-0.7-1.1-1.0-0.8-0.5
Std. dev. reaction times5.39.813.83.53.73.23.03.52.82.62.33.73.42.3
Reaction time trials completed0.91.62.2-1.4-1.5-1.3-1.0-1.3-1.2-1.3-1.5-1.5-1.2-0.7
Reaction time trials AUC0.91.62.3-1.4-1.5-1.3-1.0-1.4-1.2-1.3-1.4-1.5-1.2-0.6
Run reversals in cocaine runway, females1.91.93.7-0.8-1.1-1.4-1.7-1.4-1.6-1.9-1.80.1-0.5-1.5
Run reversals in cocaine runway, males3.73.76.12.02.32.01.72.51.71.91.91.82.01.2
Latency to leave start box in cocaine runway0.10.20.5-0.6-0.4-0.1-0.3-0.5-0.1-0.3-0.2-0.3-0.4-0.7
Latency to leave start box in cocaine runway, F0.10.10.7-0.5-0.6-0.2-0.3-0.8-0.2-0.2-0.0-0.2-0.1-0.1
Latency to leave start box in cocaine runway, M0.20.21.1-0.20.10.20.10.10.1-0.2-0.4-0.2-0.6-1.0
Std. dev. time between licks in bursts4.35.910.32.42.22.62.62.52.62.53.21.52.02.3
Total sessions with >9 infusions0.20.20.90.3-0.1-0.3-0.4-0.1-0.4-0.6-0.60.70.1-1.0
Short access day 1 total inactive lever presses1.11.54.51.61.61.11.01.10.80.60.22.11.60.2
Short access day 10 total inactive lever presses0.81.94.3-0.30.41.11.50.81.22.12.0-2.0-1.31.2
Short access day 1 total infusions0.20.31.40.40.2-0.1-0.2-0.0-0.2-0.5-0.51.20.4-1.0
Short access day 10 total infusions0.10.10.2-0.1-0.3-0.5-0.4-0.2-0.4-0.4-0.40.1-0.1-0.3
Short access total infusions0.40.51.0-0.0-0.3-0.7-0.8-0.4-0.7-1.0-1.00.90.2-0.9
Short access day 1 locomotion0.10.20.5-0.20.10.30.30.40.30.50.7-0.6-0.60.1
Short access day 10 total locomotion1.32.44.51.61.61.91.90.52.02.11.70.20.61.2
Short access total locomotion0.40.50.90.70.80.90.80.00.90.80.80.20.40.8
One hour access (0.3 mA shock)0.30.31.4-0.30.0-0.10.01.10.00.51.2-0.30.00.8
Compulsive drug intake1.92.36.40.31.21.31.51.41.42.02.3-0.50.42.5
One hour access (shock baseline)0.40.61.50.1-0.2-0.6-0.90.3-0.8-0.9-0.81.10.5-1.2
Social response proportion0.20.20.60.80.50.70.6-0.40.70.40.50.30.2-0.1
Social responses0.50.61.20.80.51.01.10.11.11.11.0-0.3-0.10.4
Social time7.09.516.92.22.83.33.63.03.44.14.10.71.73.2
Soleus weight6.418.726.25.14.94.84.53.34.63.94.04.34.13.6
Bone: stiffness0.10.20.8-0.2-0.3-0.10.1-0.90.20.2-0.0-0.5-0.40.5
Tibialis anterior weight0.20.51.3-0.7-1.0-0.7-0.5-1.0-0.4-0.10.2-1.2-1.0-0.1
Time to tail flick, vehicle, before self-admin2.32.49.20.20.61.21.60.61.51.92.2-1.10.23.0
Time to tail flick, vehicle, after self-admin0.50.71.20.81.00.90.81.10.80.80.60.70.90.8
Time to tail flick, test, before self-admin0.40.41.6-0.6-0.7-0.20.00.2-0.20.50.7-1.3-0.90.0
Time to tail flick, test, after self-admin0.40.43.20.20.30.40.41.8-0.00.50.70.20.30.6
Delta time to tail flick, vehicle, before/after SA2.42.36.0-0.8-0.8-1.5-1.8-0.0-1.8-1.8-2.20.8-0.2-2.4
Delta time to tail flick, test, before/after SA0.20.20.4-0.6-0.1-0.4-0.50.4-0.6-0.6-0.6-0.2-0.20.1
Tibia length4.010.915.93.73.93.94.02.43.83.52.12.72.92.8
Ambulatory time before self-admin0.30.51.10.40.50.71.10.40.81.00.9-0.10.10.9
Ambulatory time after self-admin1.11.32.91.21.01.41.70.41.31.51.00.40.50.9
Bone: tissue strength0.30.31.30.10.2-0.4-0.4-0.1-0.3-0.4-1.10.91.00.1
Total heroin consumption0.60.71.70.30.50.91.30.90.91.31.0-0.5-0.30.8
Bone: trabecular number0.50.92.2-1.5-1.1-1.3-1.2-0.1-1.2-0.60.0-0.9-0.70.3
Bone: trabecular spacing0.50.72.01.40.91.01.0-0.20.90.3-0.61.00.6-0.3
Bone: trabecular thickness0.20.21.4-0.5-0.0-0.5-0.40.3-0.4-0.20.30.00.31.2
Bone: trabecular tissue density0.40.61.71.10.70.70.61.10.30.2-0.11.30.5-0.8
Water consumed over 24 hours0.20.20.60.20.70.50.30.40.50.70.20.60.50.3
Number of responses in last shaping day0.70.83.91.00.50.40.0-0.00.1-0.5-0.41.60.5-2.0