Hub : Genes

Nudt14

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver mRNA stability Nudt14 0.13 0.09 5.9e-14 0.11 0.12 0.12 0.12 1.7e-12 7.2e-13 6.4e-13 9.6e-13
2 IC gene expression Nudt14 0.27 0.13 2.8e-12 0.17 0.24 0.22 0.23 1.5e-07 1.5e-10 1.0e-09 3.9e-10
3 IC mRNA stability Nudt14 0.1 0.08 1.1e-03 0.06 0.08 0.05 0.07 1.8e-03 4.4e-04 2.7e-03 9.1e-04
4 Adipose mRNA stability Nudt14 0.18 0.1 0.0e+00 0.16 0.16 0.15 0.16 2.0e-17 2.0e-17 1.2e-16 7.2e-17
5 LHb gene expression Nudt14 0.71 0.23 1.1e-07 0.28 0.27 0.25 0.25 1.9e-07 3.6e-07 9.7e-07 1.3e-06
6 BLA mRNA stability Nudt14 0.22 0.13 2.6e-09 0.15 0.14 0.16 0.15 3.5e-08 4.9e-08 8.3e-09 3.2e-08
7 LHb mRNA stability Nudt14 0.19 0.12 7.6e-05 0.15 0.16 0.14 0.16 2.4e-04 1.6e-04 4.0e-04 1.4e-04
8 pVTA mRNA stability Nudt14 0.11 0.07 2.6e-12 0.13 0.15 0.14 0.15 1.8e-10 2.7e-12 1.1e-11 6.5e-12
9 IL gene expression Nudt14 0.19 0.12 5.5e-05 0.16 0.15 0.13 0.14 1.4e-04 2.3e-04 5.6e-04 2.5e-04
10 PL gene expression Nudt14 0.18 0.08 0.0e+00 0.31 0.32 0.32 0.32 5.8e-35 1.8e-35 2.3e-35 1.4e-35
11 Liver gene expression Nudt14 0.06 0.04 2.0e-08 0.06 0.06 0.05 0.05 1.8e-07 5.8e-07 2.3e-06 1.3e-06
12 PL mRNA stability Nudt14 0.07 0.05 8.4e-11 0.1 0.1 0.11 0.11 3.4e-11 1.8e-11 1.0e-11 9.8e-12
13 BLA gene expression Nudt14 0.35 0.15 0.0e+00 0.36 0.37 0.37 0.37 3.8e-20 1.2e-20 2.3e-20 1.7e-20
14 Adipose gene expression Nudt14 0.02 0.02 7.3e-03 0.02 0.01 0.01 0.01 5.8e-03 3.8e-02 8.8e-03 2.2e-02
15 IL mRNA stability Nudt14 0.17 0.12 1.3e-04 0.14 0.12 0.09 0.14 3.9e-04 7.3e-04 4.1e-03 2.4e-04
16 NAcc mRNA stability Nudt14 0.07 0.04 2.6e-14 0.09 0.1 0.08 0.08 5.1e-13 1.9e-14 1.5e-12 2.8e-12
17 pVTA gene expression Nudt14 0.31 0.13 0.0e+00 0.36 0.39 0.37 0.39 1.5e-30 2.3e-33 2.1e-31 9.6e-33
18 RMTg gene expression Nudt14 0.25 0.14 8.0e-07 0.26 0.23 0.23 0.22 1.3e-07 1.0e-06 7.7e-07 1.2e-06
19 Brain mRNA stability Nudt14 0.18 0.08 0.0e+00 0.29 0.04 0.3 0.18 5.8e-27 2.7e-04 8.4e-28 1.5e-16
20 OFC gene expression Nudt14 0.16 0.12 7.6e-04 0.16 0.11 0.12 0.15 1.2e-04 1.3e-03 9.1e-04 2.4e-04
21 NAcc gene expression Nudt14 0.11 0.06 0.0e+00 0.12 0.14 0.14 0.13 2.3e-17 7.0e-21 4.7e-20 1.5e-19
22 Brain gene expression Nudt14 0.35 0.14 0.0e+00 0.38 0.02 0.39 0.29 3.8e-37 4.2e-03 5.7e-38 3.3e-27

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22
Bone: apparent density0.10.10.30.40.40.40.30.40.20.40.30.20.50.30.60.3-0.30.60.30.30.30.50.30.20.5
Area under the delay curve1.51.82.2-1.3-1.4-1.5-1.4-1.5-1.4-1.4-1.4-1.3-1.4-1.4-1.4-1.31.4-1.1-1.2-1.4-1.5-1.2-1.3-1.1-1.1
BMI with tail2.48.410.2-2.7-2.9-2.8-3.0-3.2-2.6-3.1-3.0-2.4-3.1-3.2-3.2-3.12.6-3.1-3.0-2.9-2.4-3.1-2.3-3.0-2.9
BMI without tail1.64.76.7-1.9-2.3-2.2-2.4-2.6-1.9-2.4-2.3-1.5-2.4-2.5-2.5-2.41.6-2.3-2.3-2.2-1.9-1.9-1.7-2.2-2.1
Body weight1.35.68.22.72.52.62.42.22.72.42.42.92.32.22.22.2-2.52.22.32.32.62.22.42.21.6
Weight adjusted by age0.20.30.60.60.60.60.80.60.40.50.60.50.50.50.60.7-0.40.60.60.60.40.50.50.60.1
Bone surface0.20.40.9-0.9-0.7-0.8-0.7-0.5-0.9-0.6-0.6-0.9-0.5-0.6-0.4-0.40.9-0.5-0.5-0.5-0.8-0.6-0.9-0.4-0.3
Bone volume0.10.20.4-0.6-0.5-0.6-0.6-0.4-0.6-0.5-0.4-0.6-0.4-0.5-0.3-0.30.6-0.4-0.3-0.4-0.6-0.5-0.6-0.3-0.1
Breakpoint value in progressive ratio session0.50.61.10.80.91.01.00.90.90.90.80.70.80.80.70.7-0.80.80.60.70.90.61.00.50.5
Number of licking bursts1.01.62.3-1.5-1.4-1.5-1.0-1.2-1.4-1.3-1.2-1.4-1.2-1.2-1.2-1.11.4-1.3-1.1-1.1-1.3-1.4-1.4-1.0-0.9
Context. condit. distance diff. score3.44.24.92.12.01.92.12.22.12.12.02.12.12.02.02.1-2.11.92.12.02.11.92.12.11.9
Locomotion velocity, session 10.10.10.30.30.40.30.40.50.20.40.40.20.40.30.50.4-0.20.50.30.30.20.40.20.30.3
Locomotion distance, session 10.20.20.5-0.5-0.4-0.3-0.4-0.2-0.6-0.3-0.4-0.6-0.3-0.4-0.2-0.50.6-0.2-0.6-0.6-0.6-0.2-0.6-0.7-0.4
Locomotion velocity, session 20.30.40.6-0.8-0.7-0.8-0.7-0.6-0.7-0.6-0.6-0.7-0.6-0.5-0.5-0.50.7-0.5-0.5-0.6-0.7-0.6-0.7-0.5-0.4
Locomotion distance, session 20.71.01.3-1.2-1.1-1.1-1.0-0.8-1.1-1.0-1.0-1.1-1.0-0.9-1.0-0.91.1-1.0-0.9-1.0-1.1-1.0-1.1-0.9-0.9
Locomotion velocity, session 30.10.10.4-0.5-0.2-0.2-0.20.2-0.6-0.1-0.2-0.6-0.00.20.0-0.10.60.0-0.3-0.2-0.6-0.1-0.6-0.3-0.2
Locomotion distance, session 30.10.20.5-0.6-0.3-0.4-0.3-0.1-0.7-0.3-0.3-0.7-0.2-0.1-0.2-0.20.7-0.2-0.2-0.3-0.7-0.3-0.7-0.2-0.2
Stereotopy head waving bouts, day 30.00.00.10.20.20.20.30.30.20.20.20.20.20.30.10.2-0.20.20.20.20.20.20.20.20.2
Stereotopy head waving duration, day 30.10.10.10.30.30.20.40.30.30.30.30.30.30.40.20.4-0.30.30.40.30.30.30.30.40.3
Locomotion velocity, session 70.10.10.30.50.40.50.30.30.40.30.30.40.20.20.20.1-0.40.20.10.20.40.30.4-0.0-0.1
Locomotion distance, session 70.91.11.2-1.1-1.1-1.0-1.1-0.9-1.1-1.0-1.0-1.1-1.0-1.1-1.0-1.01.1-1.1-1.0-1.0-1.1-1.0-1.1-1.0-1.0
Stereotopy head waving bouts, day 72.52.83.71.71.71.81.61.61.61.71.71.61.71.71.81.6-1.61.91.61.61.61.81.61.51.5
Stereotopy head waving duration, day 71.72.12.71.51.51.61.41.41.41.51.51.41.51.41.61.4-1.41.71.31.31.41.51.41.21.3
Locomotion velocity, session 82.53.03.82.01.81.81.71.81.81.81.71.81.71.81.71.7-1.91.61.61.61.81.71.81.61.3
Locomotion distance, session 80.40.61.10.70.80.70.81.00.70.80.70.70.80.90.80.8-0.70.80.70.70.70.80.60.70.6
Degree of sensitization distance0.10.10.4-0.2-0.4-0.3-0.4-0.5-0.2-0.4-0.4-0.1-0.5-0.6-0.5-0.50.2-0.4-0.4-0.4-0.1-0.3-0.1-0.4-0.4
Degree of sensitization stereotypy1.21.31.61.21.21.31.01.01.21.21.21.11.11.11.21.1-1.11.31.11.11.11.21.11.01.0
Conditioned locomotion1.82.12.51.61.51.51.31.51.51.41.41.51.41.41.41.4-1.51.41.41.41.51.41.61.41.2
Cocaine response after cond. corrected0.00.00.10.10.20.40.10.30.10.20.1-0.00.20.20.3-0.10.10.2-0.2-0.10.00.3-0.0-0.3-0.1
Cocaine response after cond. not corrected0.30.30.9-0.4-0.4-0.2-0.5-0.3-0.5-0.4-0.5-0.5-0.5-0.5-0.5-0.70.6-0.5-0.8-0.7-0.4-0.4-0.5-0.9-0.7
Cocaine response before conditioning2.93.44.9-1.7-1.9-1.9-1.9-2.0-1.6-2.0-1.8-1.7-2.1-2.0-2.1-1.81.6-2.2-1.7-1.7-1.6-2.1-1.6-1.7-1.8
Saline control response0.10.20.50.20.40.30.30.70.00.40.40.10.60.70.60.5-0.20.50.40.4-0.00.50.10.40.4
Bone: connectivity density0.50.71.10.80.90.90.80.90.80.90.90.71.00.81.00.8-0.81.00.80.80.80.90.80.80.8
Bone: cortical apparent density3.75.16.62.22.22.02.42.32.32.22.32.32.22.22.22.4-2.22.12.52.42.22.12.32.62.1
Bone: cortical area0.10.20.60.30.50.40.50.80.10.40.50.20.60.60.60.6-0.20.60.40.40.20.50.20.40.4
Bone: cortical porosity0.60.60.80.80.80.70.90.70.80.70.80.80.70.80.70.8-0.80.80.80.80.80.60.70.90.7
Bone: cortical porosity0.20.20.40.60.50.60.70.40.50.40.50.50.40.50.30.4-0.50.40.40.50.50.30.40.40.3
Bone: cortical thickness1.01.62.31.31.41.41.31.51.11.31.31.11.41.41.41.2-1.11.51.11.11.11.41.21.01.0
Bone: cortical thickness0.50.61.00.60.70.60.70.90.60.80.80.50.91.00.90.9-0.60.90.90.90.40.80.51.01.0
Bone: cortical tissue density3.64.96.32.12.11.92.32.32.22.12.22.22.12.12.12.4-2.22.12.42.32.22.02.32.52.0
Condit. Reinf. active minus inactive responses0.20.20.4-0.4-0.4-0.4-0.5-0.5-0.4-0.3-0.5-0.4-0.4-0.5-0.3-0.50.4-0.2-0.6-0.5-0.4-0.2-0.4-0.6-0.4
Condit. Reinf. active-inactive response ratio1.41.52.2-1.1-1.2-1.0-1.3-1.3-1.1-1.2-1.3-1.1-1.3-1.4-1.2-1.41.1-1.2-1.4-1.3-1.1-1.0-1.1-1.5-1.2
Condit. Reinf. active responses0.10.10.30.50.40.50.30.30.40.50.30.30.40.30.50.2-0.40.50.20.20.30.60.30.10.3
Condit. Reinf. inactive responses2.32.83.71.51.71.71.71.81.41.81.71.41.91.91.91.7-1.41.91.61.61.41.81.41.61.5
Incentive salience index mean0.00.00.20.30.30.40.10.10.20.20.10.10.20.20.3-0.0-0.10.3-0.10.00.10.40.1-0.2-0.1
Condit. Reinf. lever presses0.30.41.00.90.81.00.80.60.70.70.70.70.60.70.60.4-0.70.60.40.50.70.70.70.30.2
Condit. Reinf. active minus inactive responses0.30.40.70.50.50.40.70.70.60.50.60.60.60.50.60.7-0.70.50.80.70.60.50.60.80.6
Condit. Reinf. active-inactive response ratio0.10.10.30.20.20.10.30.40.40.30.30.40.30.20.30.4-0.40.30.50.40.40.30.40.60.4
Condit. Reinf. active responses0.00.00.1-0.2-0.2-0.3-0.0-0.2-0.2-0.2-0.1-0.1-0.2-0.3-0.2-0.00.1-0.30.0-0.0-0.1-0.3-0.10.1-0.1
Condit. Reinf. inactive responses0.40.50.7-0.7-0.7-0.7-0.6-0.8-0.7-0.7-0.7-0.7-0.8-0.8-0.7-0.70.7-0.8-0.7-0.7-0.7-0.8-0.7-0.7-0.6
Condit. Reinf. lever presses2.63.74.6-2.1-2.1-2.2-2.1-1.9-2.0-2.0-1.9-1.9-1.9-2.0-1.9-1.81.9-2.0-1.8-1.8-1.9-1.9-1.9-1.6-1.5
Condit. Reinf. lever reinforcers received0.00.00.1-0.2-0.2-0.3-0.0-0.1-0.1-0.2-0.1-0.1-0.1-0.2-0.10.00.1-0.20.1-0.0-0.1-0.2-0.10.1-0.0
Conditioned reinforcement - actives0.10.10.30.40.30.20.30.40.30.30.30.30.30.20.30.4-0.30.30.50.40.50.00.30.50.3
Conditioned reinforcement - inactives0.30.51.01.00.80.80.60.80.60.70.70.70.80.70.80.7-0.70.80.70.60.80.70.80.60.3
Conditioned locomotion0.10.10.60.30.20.30.20.20.30.20.20.20.20.10.20.1-0.20.30.10.10.8-0.40.80.1-0.0
Patch foraging indifference point 0 sec6.812.515.63.83.63.63.53.63.43.53.53.83.63.53.63.5-3.73.73.43.43.13.93.43.33.1
Patch foraging indifference point AUC5.58.011.03.33.03.22.82.83.02.82.83.12.82.72.82.6-3.12.82.42.62.83.13.02.22.2
Delay disc. indifference point, 0s delay0.20.20.40.50.40.40.50.40.50.50.50.60.40.50.40.5-0.50.50.50.50.40.50.30.60.6
Delay disc. indifference point, 16s delay2.12.33.2-1.5-1.6-1.7-1.6-1.7-1.7-1.5-1.6-1.5-1.5-1.6-1.5-1.51.6-1.3-1.4-1.6-1.8-1.2-1.5-1.4-1.3
Delay disc. indifference point, 2s delay4.34.85.9-2.4-2.3-2.4-2.2-2.2-2.3-2.2-2.2-2.4-2.2-2.2-2.2-2.02.3-2.1-1.9-2.0-2.3-2.3-2.2-1.8-1.6
Delay disc. indifference point, 24s delay1.41.51.9-1.1-1.3-1.3-1.2-1.2-1.4-1.2-1.3-1.3-1.2-1.3-1.2-1.21.3-1.1-1.2-1.3-1.2-1.2-1.2-1.2-1.3
Delay disc. indifference point, 4s delay0.50.60.9-0.6-0.8-1.0-0.8-0.9-0.7-0.8-0.8-0.6-0.8-0.8-0.8-0.60.7-0.7-0.5-0.7-0.8-0.8-0.7-0.4-0.6
Delay disc. indifference point, 8s delay0.60.70.9-0.6-0.9-0.9-0.9-0.9-0.9-0.9-0.9-0.8-0.9-0.9-0.9-0.90.8-0.7-0.8-0.9-0.8-0.8-0.7-0.7-0.9
Indifference point function ln k0.10.30.80.30.40.30.50.50.50.40.50.40.50.40.40.7-0.30.40.80.70.50.10.40.90.5
Indifference point function log k0.10.30.80.30.40.30.50.50.50.40.50.40.50.40.40.7-0.30.40.80.70.50.10.40.90.5
Patch foraging total patch changes 0 sec7.814.717.94.23.93.93.83.93.83.83.84.23.93.83.93.8-4.13.93.73.73.54.23.83.53.3
Patch foraging total patch changes 12 sec4.25.57.82.52.32.22.12.32.22.22.32.62.42.12.42.3-2.52.72.32.22.02.82.42.22.4
Patch foraging total patch changes 18 sec2.53.85.82.31.91.91.81.81.81.81.82.31.91.82.01.8-2.32.11.71.71.72.42.11.61.8
Patch foraging total patch changes 24 sec1.22.13.01.71.51.51.61.41.41.31.41.71.41.31.41.3-1.71.51.21.31.31.61.71.11.1
Patch foraging total patch changes 6 sec7.811.817.14.13.63.73.43.43.43.33.33.93.33.33.43.1-4.03.43.03.13.23.93.82.72.9
Patch foraging time to switch 0 sec8.918.220.8-4.4-4.4-4.3-4.5-4.6-4.4-4.3-4.3-4.3-4.3-4.3-4.2-4.44.2-4.3-4.3-4.3-4.1-4.2-4.0-4.2-3.5
Patch foraging water rate 0 sec13.328.032.75.25.45.25.45.75.25.45.45.15.55.55.45.6-5.15.35.55.45.05.05.05.44.6
Patch foraging water rate 12 sec3.67.611.02.62.62.32.82.82.72.72.82.72.82.62.73.1-2.82.63.23.02.62.52.63.32.6
Patch foraging water rate 18 sec2.94.45.92.02.11.92.42.42.22.02.22.02.12.11.92.4-2.01.72.42.32.11.62.12.41.8
Patch foraging water rate 24 sec2.23.04.41.61.71.52.02.01.81.71.81.61.71.91.62.0-1.71.32.01.91.81.21.62.11.5
Patch foraging water rate 6 sec3.95.66.82.42.42.32.42.62.42.42.42.32.42.52.32.5-2.42.22.52.42.32.12.42.52.0
Seeking ratio, delayed vs. immediate footshock0.20.20.40.50.50.40.60.60.60.50.50.30.40.60.40.5-0.50.30.50.50.20.50.20.50.4
Distance traveled before self-admin0.50.71.2-0.6-0.8-0.8-0.9-0.8-0.9-0.8-0.9-0.9-0.8-0.9-0.8-0.90.7-0.9-0.9-0.9-0.9-0.8-0.5-0.9-1.1
Distance traveled after self-admin0.10.10.40.30.10.00.20.20.10.20.20.10.20.10.20.3-0.50.20.30.30.00.70.70.40.5
Extensor digitorum longus weight9.637.641.56.46.36.26.26.26.16.26.26.16.26.36.26.2-6.16.06.16.16.25.96.26.05.2
Bone: elastic displacement0.10.10.2-0.4-0.4-0.5-0.3-0.4-0.2-0.2-0.2-0.2-0.1-0.3-0.1-0.10.30.00.1-0.1-0.2-0.2-0.30.20.2
Bone: elastic work0.70.91.5-1.2-1.1-1.2-0.9-1.0-1.0-0.9-0.9-1.0-0.9-0.9-0.9-0.81.0-0.8-0.6-0.8-1.0-1.0-1.0-0.5-0.5
Bone: endosteal estimation1.94.15.9-2.4-2.2-2.4-2.0-2.1-2.2-2.0-2.0-2.2-2.0-2.0-1.9-1.72.2-2.0-1.7-1.8-2.2-2.1-2.3-1.5-1.4
Bone: endosteal perimeter0.40.81.3-1.1-0.8-0.9-0.7-0.6-1.1-0.9-0.8-1.1-0.7-0.7-0.8-0.61.1-0.8-0.7-0.7-1.1-0.8-1.2-0.7-0.6
Epididymis fat weight1.96.58.7-2.2-2.6-2.4-2.6-2.8-2.3-2.6-2.6-2.0-2.7-2.8-2.6-2.82.1-2.7-2.8-2.7-3.0-1.7-2.6-2.9-2.3
Delta time in closed arm before/after self-admin0.10.10.30.50.10.1-0.00.00.20.00.10.6-0.10.1-0.10.1-0.4-0.30.10.10.3-0.00.50.1-0.2
Delta time in open arm before/after self-admin1.21.21.80.81.11.11.11.21.01.11.11.21.21.11.11.1-0.91.31.01.10.91.40.61.01.2
Diff in mean of infusions in LGA sessions0.91.12.21.11.11.21.21.31.01.11.01.30.91.00.90.9-1.00.90.70.80.81.50.90.60.8
Delay discount exponential model param1.51.72.01.21.41.41.31.41.41.31.31.31.31.41.31.3-1.41.11.21.31.41.21.31.11.1
Extinction: sum of active levers before priming0.10.10.50.40.30.40.40.40.40.30.20.40.30.20.40.1-0.60.5-0.00.10.40.70.5-0.10.5
Active lever presses in extinction session 61.81.82.81.31.31.21.31.41.31.31.31.41.31.31.31.3-1.41.41.31.31.21.31.71.31.3
Bone: final force0.30.50.9-1.0-0.7-0.9-0.5-0.5-0.9-0.7-0.6-0.8-0.6-0.6-0.6-0.40.9-0.6-0.4-0.5-0.9-0.8-0.8-0.3-0.3
Bone: final moment0.20.30.6-0.8-0.5-0.7-0.3-0.3-0.7-0.6-0.4-0.7-0.4-0.4-0.4-0.20.7-0.4-0.2-0.3-0.7-0.6-0.6-0.1-0.2
Food consumed during 24 hour testing period0.70.91.21.01.11.01.11.01.01.01.00.91.01.10.91.0-0.90.71.01.01.00.80.91.00.7
Glucose0.00.00.1-0.3-0.1-0.30.00.0-0.30.00.0-0.20.10.00.20.20.20.40.20.1-0.20.1-0.20.30.3
Heart weight0.30.40.50.70.60.60.70.60.70.60.60.60.60.50.60.7-0.70.60.70.70.60.50.70.70.5
Delay discount hyperbolic model param1.61.82.31.31.41.51.41.41.41.41.41.41.41.41.41.3-1.41.11.21.31.51.21.41.11.1
Intermittent access intake day 1-15 change1.12.23.1-1.0-1.5-1.4-1.6-1.5-1.3-1.6-1.6-0.9-1.6-1.5-1.6-1.71.0-1.5-1.7-1.7-1.1-1.4-0.8-1.8-1.6
Intermittent access intake escalation1.12.33.3-1.1-1.6-1.5-1.7-1.6-1.4-1.6-1.7-1.0-1.6-1.6-1.6-1.81.1-1.5-1.8-1.8-1.3-1.3-1.0-1.8-1.6
Intermittent access intake escalation 20.60.71.1-0.7-0.9-0.8-1.0-0.9-0.7-0.9-0.9-0.6-0.9-0.9-0.8-1.00.4-0.7-1.0-1.0-0.7-0.6-0.6-1.0-0.6
Intermitt. access day 1 inactive lever presses0.31.02.31.21.01.00.91.01.01.11.01.01.10.91.10.9-1.01.20.90.90.81.50.90.90.8
Intermitt. access day 15 inactive lever presses1.53.04.11.61.81.71.81.81.71.81.81.71.81.81.81.8-1.42.01.81.71.81.81.51.81.6
Intermitt. access escalation Index0.30.41.00.50.50.40.70.60.40.60.60.70.70.70.70.7-0.50.70.70.6-0.11.00.30.80.7
Intermittent access day 1 total infusions0.00.10.2-0.0-0.2-0.1-0.0-0.0-0.3-0.3-0.2-0.1-0.2-0.3-0.3-0.20.1-0.3-0.3-0.30.1-0.40.3-0.3-0.4
Intermittent access day 15 total infusions0.81.21.7-0.8-1.1-1.1-1.0-1.0-1.1-1.2-1.2-0.7-1.2-1.2-1.2-1.20.9-1.2-1.3-1.3-0.7-1.2-0.4-1.3-1.3
Intermittent access terminal intake (last 3 days)1.21.62.1-1.1-1.3-1.2-1.2-1.1-1.3-1.3-1.3-1.0-1.3-1.4-1.3-1.41.1-1.2-1.4-1.4-1.1-1.3-1.0-1.4-1.4
Intermittent access total infusions0.30.40.7-0.4-0.6-0.6-0.4-0.4-0.6-0.7-0.6-0.3-0.7-0.6-0.7-0.60.6-0.7-0.7-0.7-0.2-0.8-0.2-0.7-0.8
Intermittent access day 1 locomotion0.30.40.7-0.5-0.5-0.4-0.4-0.4-0.6-0.6-0.6-0.3-0.6-0.7-0.6-0.70.7-0.6-0.8-0.7-0.3-0.8-0.4-0.9-0.8
Intermittent access day 15 total locomotion0.50.81.5-0.5-0.9-0.9-1.0-0.9-0.7-1.0-1.0-0.2-1.1-1.0-1.1-1.00.6-1.1-0.9-1.0-0.3-1.2-0.1-0.9-1.2
Intermittent access total locomotion0.10.21.0-0.3-0.3-0.2-0.2-0.2-0.3-0.4-0.3-0.1-0.4-0.4-0.4-0.40.5-0.3-0.4-0.40.4-1.00.2-0.5-0.7
Intermittent access standard deviation0.10.10.70.3-0.10.1-0.2-0.1-0.1-0.3-0.30.1-0.3-0.2-0.3-0.5-0.1-0.3-0.6-0.50.1-0.20.1-0.8-0.7
Left kidney weight2.511.514.33.63.53.53.53.33.63.43.43.83.23.23.13.4-3.53.13.53.43.43.03.53.42.9
Right kidney weight1.88.211.23.12.92.93.02.83.02.82.93.42.72.62.62.9-3.12.52.92.92.92.53.32.92.3
Cocaine induced anxiety0.71.01.50.80.90.80.91.00.91.11.00.81.01.11.01.1-1.01.01.11.01.20.61.01.11.2
Post-drug Anxiety1.51.62.40.91.21.11.31.31.21.41.31.01.31.31.31.4-1.01.21.51.41.30.80.81.51.5
Baseline Anxiety0.20.20.6-0.6-0.4-0.4-0.3-0.3-0.3-0.4-0.4-0.5-0.4-0.5-0.4-0.40.6-0.5-0.4-0.4-0.8-0.3-0.8-0.3-0.4
Tail length5.521.524.64.84.74.64.64.64.84.74.75.04.64.64.64.7-4.74.64.74.64.54.74.44.74.1
Length with tail9.842.845.76.86.86.76.66.66.76.86.66.86.76.66.76.6-6.46.56.66.56.46.56.16.45.6
Length without tail6.019.322.54.54.74.74.64.74.54.64.54.44.64.54.54.4-4.14.44.34.44.44.13.94.13.5
Times rat made contact with spout0.30.30.50.50.60.60.70.70.40.60.50.40.60.60.70.5-0.40.60.50.50.40.60.40.40.5
Lifetime Intake0.40.51.1-0.6-0.7-0.7-0.5-0.5-0.8-0.8-0.7-0.6-0.8-0.7-0.8-0.70.7-0.7-0.7-0.7-0.4-1.0-0.4-0.7-0.9
Liver weight, left3.96.48.82.82.62.62.42.52.72.42.52.72.42.42.42.4-2.72.32.52.52.72.43.02.42.2
Liver weight, right0.00.10.20.30.30.40.10.30.30.20.20.40.20.20.20.1-0.20.10.10.20.40.10.40.00.0
Locomotor activity0.10.20.30.40.40.40.50.50.50.30.40.40.30.30.30.4-0.50.10.50.50.40.30.40.50.3
Locomotor testing distance0.00.10.20.20.30.20.30.40.30.30.30.20.30.30.20.3-0.30.10.40.30.30.30.10.40.4
Locomotor testing rearing1.83.74.8-2.1-1.9-1.8-1.8-1.5-2.0-1.9-1.9-2.1-1.8-1.7-1.9-1.92.1-2.0-2.0-1.9-1.9-1.9-2.2-2.0-1.8
Locomotion in novel chamber1.31.73.11.11.21.01.31.21.21.21.31.21.31.11.31.5-1.11.41.61.51.41.01.41.71.3
Locomotion in novel chamber post-restriction0.10.20.6-0.6-0.4-0.4-0.4-0.3-0.6-0.4-0.3-0.7-0.4-0.3-0.5-0.30.7-0.5-0.3-0.3-0.7-0.7-0.7-0.2-0.4
Fecal boli incidents, locomotor time 10.20.20.5-0.4-0.3-0.1-0.5-0.5-0.3-0.5-0.4-0.3-0.5-0.5-0.6-0.60.4-0.5-0.6-0.5-0.2-0.7-0.3-0.7-0.6
Change in fecal boli incidents, locomotor task0.80.81.20.90.80.71.01.10.80.80.90.80.91.00.71.0-0.90.61.00.90.60.90.81.10.7
Time >=10cm from walls, locomotor time 12.72.84.72.01.92.21.71.71.91.81.71.81.71.81.71.4-1.81.61.31.51.71.91.41.11.1
Bouts of movement, locomotor time 11.31.53.3-1.4-1.2-1.1-1.3-1.1-1.3-1.2-1.2-1.3-1.1-1.1-1.1-1.21.4-0.8-1.3-1.2-1.4-1.0-1.8-1.3-0.9
Total resting periods, locomotor time 11.71.93.9-1.6-1.4-1.4-1.5-1.4-1.4-1.4-1.4-1.4-1.3-1.3-1.2-1.41.6-1.0-1.4-1.4-1.5-1.2-2.0-1.4-0.9
Rest time, locomotor task time 10.70.81.5-0.8-1.0-1.1-1.2-1.0-0.8-1.0-0.9-0.7-0.9-1.0-0.9-0.80.8-0.9-0.8-0.9-1.1-0.6-1.2-0.7-0.7
Distance moved, locomotor task time 10.30.50.9-0.8-0.7-0.7-0.5-0.6-0.7-0.7-0.7-0.8-0.7-0.8-0.7-0.70.7-0.8-0.7-0.7-0.4-0.9-0.3-0.7-0.6
Vertical activity count, locomotor time 10.00.00.30.20.10.10.1-0.10.20.10.00.1-0.1-0.0-0.1-0.0-0.3-0.20.10.00.3-0.10.50.1-0.0
Time >=10cm from walls, locomotor time 21.72.53.61.51.81.91.81.61.61.61.71.51.61.71.61.5-1.41.71.41.61.51.61.21.31.3
Bouts of movement, locomotor time 20.10.20.7-0.8-0.5-0.80.0-0.1-0.6-0.3-0.2-0.4-0.2-0.3-0.20.10.6-0.00.2-0.0-0.8-0.2-0.80.30.3
Total resting periods, locomotor time 20.10.20.8-0.7-0.6-0.9-0.1-0.3-0.7-0.5-0.4-0.4-0.3-0.4-0.4-0.10.6-0.2-0.0-0.2-0.8-0.3-0.80.20.1
Rest time, locomotor task time 20.10.10.30.1-0.4-0.5-0.5-0.4-0.2-0.3-0.40.0-0.3-0.3-0.3-0.30.0-0.3-0.3-0.4-0.1-0.2-0.1-0.2-0.3
Distance moved, locomotor task time 20.30.30.9-0.8-0.4-0.4-0.4-0.5-0.6-0.5-0.5-0.9-0.5-0.6-0.5-0.50.8-0.5-0.5-0.5-0.3-0.9-0.5-0.6-0.6
Vertical activity count, locomotor time 20.20.20.40.40.60.60.70.50.40.50.60.20.50.50.50.5-0.40.30.50.50.40.40.40.40.4
Light reinforcement 10.00.00.1-0.10.20.20.20.20.10.10.2-0.10.10.10.00.20.3-0.00.20.20.0-0.3-0.30.2-0.0
Light reinforcement 20.81.32.1-0.9-1.0-0.8-1.2-1.1-0.9-1.1-1.1-0.8-1.2-1.4-1.2-1.31.0-1.4-1.3-1.2-0.9-1.1-0.9-1.3-1.3
Bone: marrow area1.83.95.7-2.4-2.2-2.4-2.0-2.0-2.2-2.0-1.9-2.1-1.9-1.9-1.9-1.62.2-2.0-1.6-1.7-2.2-2.0-2.2-1.4-1.3
Bone: maximum diameter0.20.40.7-0.7-0.5-0.5-0.4-0.2-0.8-0.6-0.5-0.8-0.5-0.4-0.5-0.50.7-0.6-0.6-0.6-0.8-0.6-0.8-0.6-0.5
Bone: maximum force0.00.10.2-0.4-0.2-0.3-0.1-0.1-0.4-0.3-0.2-0.4-0.2-0.2-0.2-0.10.4-0.2-0.1-0.1-0.4-0.3-0.3-0.1-0.1
Bone: maximum moment0.00.00.1-0.2-0.0-0.10.10.0-0.2-0.10.0-0.2-0.0-0.1-0.00.10.20.00.10.1-0.2-0.1-0.10.10.0
Mean time between licks in bursts0.30.71.2-0.7-0.9-0.8-1.1-1.0-0.6-0.8-0.8-0.7-0.9-0.9-0.9-0.90.7-1.0-0.8-0.8-0.6-0.9-0.7-0.7-0.7
Mean num. licks in bursts1.42.33.11.81.61.81.41.51.61.61.51.61.51.51.51.3-1.61.61.31.41.51.71.61.11.1
Cd content in liver0.10.10.3-0.5-0.4-0.5-0.1-0.2-0.4-0.3-0.2-0.4-0.2-0.2-0.3-0.10.4-0.3-0.1-0.1-0.4-0.4-0.40.0-0.2
Co content in liver0.60.61.10.50.70.60.81.00.50.90.80.51.01.01.00.9-0.51.10.90.80.50.80.50.90.8
Cu content in liver1.51.82.0-1.4-1.4-1.3-1.3-1.3-1.3-1.3-1.4-1.3-1.3-1.3-1.3-1.41.3-1.4-1.4-1.4-1.3-1.2-1.3-1.4-1.2
Fe content in liver0.80.91.3-1.1-1.0-1.0-0.8-0.8-1.1-0.9-0.9-1.1-0.9-0.8-0.8-0.91.1-1.0-0.9-0.9-1.1-0.9-1.1-0.9-0.8
K content in liver0.90.81.31.10.91.01.10.91.00.90.91.10.80.90.80.8-1.10.80.80.81.00.81.10.80.7
Mg content in liver0.10.10.30.40.30.20.50.20.40.20.30.50.20.20.20.3-0.40.20.40.30.40.20.40.40.3
Mn content in liver0.00.00.0-0.0-0.1-0.1-0.0-0.10.0-0.1-0.10.0-0.2-0.2-0.2-0.0-0.0-0.10.0-0.00.0-0.20.00.0-0.0
Na content in liver0.20.20.5-0.3-0.4-0.3-0.3-0.5-0.4-0.5-0.5-0.3-0.5-0.5-0.5-0.60.4-0.5-0.6-0.6-0.4-0.4-0.4-0.7-0.6
Rb content in liver0.20.20.50.20.40.30.60.60.20.50.50.20.60.60.70.6-0.20.50.60.50.20.40.20.70.7
Se content in liver0.10.10.2-0.4-0.4-0.4-0.3-0.4-0.3-0.4-0.4-0.3-0.4-0.3-0.4-0.30.3-0.3-0.4-0.4-0.3-0.3-0.3-0.3-0.2
Sr content in liver0.30.20.6-0.7-0.6-0.7-0.5-0.2-0.7-0.4-0.4-0.7-0.3-0.2-0.3-0.20.7-0.4-0.3-0.4-0.6-0.5-0.5-0.2-0.2
Zn content in liver0.10.10.30.00.1-0.00.40.30.10.20.20.20.30.30.30.4-0.20.40.40.30.20.20.20.50.4
Bone: minimum diameter0.30.50.80.50.70.60.90.90.50.70.80.50.80.80.80.9-0.50.80.90.80.50.70.50.90.7
Time in familiar zone, hab. session 10.00.00.0-0.1-0.00.00.10.1-0.10.0-0.0-0.10.10.20.1-0.00.10.1-0.1-0.1-0.10.1-0.1-0.10.1
Time in novel zone, hab. session 10.90.91.2-1.0-1.0-1.1-1.0-0.9-1.0-1.0-1.0-0.9-1.0-1.1-1.0-0.90.9-1.0-0.8-0.9-0.9-1.0-0.9-0.8-0.8
Total zone transitions, hab. session 10.60.81.2-1.0-1.0-1.1-1.0-0.9-0.9-1.0-0.9-0.9-1.0-1.0-1.0-0.80.9-0.9-0.8-0.8-0.9-1.0-0.9-0.7-0.6
Total locomotion distance, hab. session 10.00.00.1-0.1-0.2-0.3-0.2-0.10.0-0.1-0.00.0-0.0-0.1-0.10.2-0.00.10.20.10.0-0.10.00.40.3
Locomotion velocity, hab. session 10.30.40.80.50.50.40.40.50.60.60.60.50.60.50.60.7-0.50.70.80.70.50.50.50.90.8
Time in familiar zone, hab. session 20.60.71.21.11.01.10.90.90.90.80.80.90.80.80.80.6-0.90.80.50.60.90.90.90.30.4
Time in novel zone, hab. session 21.21.32.0-1.3-1.3-1.4-1.2-1.2-1.2-1.1-1.1-1.2-1.1-1.1-1.1-0.91.2-1.0-0.9-1.0-1.2-1.1-1.2-0.8-0.7
Total zone transitions, hab. session 20.10.20.3-0.4-0.4-0.3-0.4-0.2-0.5-0.3-0.4-0.5-0.2-0.3-0.2-0.40.5-0.1-0.5-0.5-0.5-0.2-0.5-0.5-0.3
Total locomotion distance, hab. session 20.20.30.60.30.40.20.50.60.40.50.40.30.60.60.60.6-0.30.70.60.50.30.60.30.60.7
Locomotion velocity, hab. session 20.30.40.80.50.50.40.70.80.50.70.60.50.70.70.80.8-0.50.90.70.60.50.70.50.80.8
Novel to familiar place preference ratio0.80.91.4-1.2-1.0-1.0-0.9-1.0-1.1-0.9-1.0-1.1-0.8-0.9-0.6-0.91.1-0.7-0.9-1.0-1.1-0.7-1.1-0.9-0.6
Novelty place preference1.01.11.8-1.3-1.2-1.2-1.0-1.1-1.3-1.0-1.0-1.3-0.9-0.9-0.7-1.01.3-0.8-1.0-1.0-1.3-0.9-1.3-0.9-0.6
Time in novel zone, NPP test0.40.40.7-0.9-0.7-0.7-0.6-0.7-0.8-0.5-0.6-0.8-0.5-0.6-0.3-0.60.8-0.4-0.6-0.6-0.8-0.5-0.8-0.6-0.3
Total zone transitions, NPP test0.50.81.30.80.90.90.81.00.81.00.90.71.00.91.10.9-0.71.20.80.80.71.00.70.80.8
Total locomotion distance, NPP test0.40.60.90.70.70.60.50.70.80.80.70.70.80.70.80.7-0.71.00.80.70.70.80.70.80.9
Locomotion velocity, NPP test0.20.30.50.40.40.40.30.50.50.60.50.50.60.50.60.6-0.50.70.60.50.50.60.50.60.6
Intraocular pressure0.40.51.4-1.0-0.8-0.9-0.5-0.7-0.8-0.6-0.7-1.2-0.6-0.8-0.5-0.60.8-0.3-0.5-0.6-0.7-0.7-0.8-0.4-0.2
Delta distance traveled before/after self-admin0.10.10.4-0.20.0-0.00.10.20.00.10.2-0.00.10.10.10.2-0.10.10.30.3-0.10.40.20.30.7
Delta ambulatory time before/after self-admin0.30.41.30.30.40.30.50.50.50.50.60.50.60.60.60.7-0.60.60.80.80.30.80.50.91.1
Parametrial fat weight0.10.10.60.60.20.40.10.00.40.10.10.6-0.0-0.1-0.1-0.0-0.7-0.20.00.10.70.10.8-0.1-0.2
Pavlov. Cond. lever latency0.00.00.2-0.00.1-0.10.10.30.10.20.20.10.20.30.20.3-0.10.10.40.30.10.10.10.40.4
Pavlov. Cond. magazine entry latency0.00.00.20.30.20.40.20.10.20.10.10.20.1-0.10.0-0.1-0.20.2-0.10.00.20.20.2-0.2-0.1
Pavlov. Cond. change in total contacts0.00.00.10.30.20.30.10.10.20.10.10.20.1-0.00.20.0-0.20.20.00.10.20.20.2-0.1-0.1
Pavlov. Cond. index score0.00.00.10.20.10.30.0-0.10.1-0.0-0.00.1-0.1-0.2-0.1-0.2-0.10.0-0.3-0.10.10.10.1-0.4-0.3
Pavlov. Cond. latency score0.00.00.10.20.10.2-0.0-0.10.1-0.0-0.00.0-0.1-0.2-0.0-0.2-0.00.0-0.2-0.10.00.10.0-0.3-0.3
Pavlov. Cond. lever contacts0.30.30.7-0.4-0.4-0.3-0.4-0.6-0.5-0.5-0.5-0.5-0.6-0.7-0.5-0.70.5-0.5-0.7-0.6-0.5-0.4-0.5-0.8-0.7
Pavlov. Cond. magazine entry number0.00.00.2-0.4-0.3-0.4-0.3-0.1-0.3-0.1-0.1-0.2-0.10.0-0.10.10.2-0.20.1-0.0-0.2-0.2-0.20.20.1
Pavlov. Cond. intertrial magazine entries8.39.911.53.23.33.23.03.43.03.33.23.03.33.43.33.2-3.03.33.13.13.03.23.03.02.7
Pavlov. Cond. lever-magazine prob. diff.0.00.00.10.20.10.2-0.0-0.10.1-0.0-0.10.0-0.1-0.2-0.0-0.3-0.00.0-0.3-0.20.00.10.0-0.4-0.3
Pavlov. Cond. response bias0.10.10.30.40.30.50.30.10.30.20.10.30.2-0.00.1-0.1-0.30.2-0.10.00.30.30.3-0.3-0.2
Pavlov. Cond. lever latency3.54.75.82.42.32.42.42.22.22.22.22.12.22.22.22.1-2.22.22.02.12.12.22.21.91.7
Pavlov. Cond. magazine entry latency3.54.35.3-2.3-2.1-2.1-2.2-2.0-2.3-2.0-2.1-2.2-2.0-1.9-1.9-2.02.3-1.9-2.1-2.0-2.3-1.9-2.3-2.0-1.6
Pavlov. Cond. change in total contacts5.38.510.1-3.2-3.0-3.1-3.0-2.8-3.1-2.9-2.9-3.0-2.9-2.8-2.8-2.93.0-2.8-2.9-2.9-3.0-2.8-3.0-2.8-2.4
Pavlov. Cond. index score4.86.57.9-2.8-2.7-2.7-2.7-2.5-2.7-2.5-2.6-2.7-2.5-2.4-2.4-2.52.7-2.4-2.5-2.5-2.7-2.4-2.7-2.4-2.0
Pavlov. Cond. latency score4.35.76.7-2.6-2.5-2.4-2.6-2.3-2.5-2.4-2.4-2.5-2.3-2.3-2.3-2.42.5-2.2-2.4-2.4-2.5-2.2-2.5-2.4-1.9
Pavlov. Cond. lever contacts4.05.66.7-2.6-2.5-2.6-2.6-2.3-2.4-2.4-2.4-2.3-2.4-2.4-2.3-2.32.4-2.3-2.2-2.3-2.4-2.3-2.4-2.1-1.8
Pavlov. Cond. magazine entry number3.54.35.82.42.22.22.11.92.42.02.12.31.91.81.82.0-2.31.82.12.12.41.82.32.01.5
Pavlov. Cond. intertrial magazine entries4.05.97.02.62.42.32.62.32.62.32.42.62.32.12.32.5-2.62.32.62.52.72.22.62.62.1
Pavlov. Cond. lever-magazine prob. diff.5.57.38.8-3.0-2.8-2.8-2.9-2.6-2.9-2.7-2.7-2.8-2.6-2.6-2.6-2.62.8-2.6-2.7-2.7-2.8-2.6-2.9-2.6-2.2
Pavlov. Cond. response bias4.05.56.6-2.6-2.5-2.6-2.6-2.3-2.4-2.4-2.4-2.3-2.3-2.3-2.3-2.32.4-2.3-2.2-2.3-2.4-2.3-2.4-2.1-1.8
Time in closed arm before self-admin6.48.210.4-2.5-3.0-3.0-3.2-2.9-3.0-2.9-3.0-2.8-2.9-3.0-2.9-3.02.4-2.9-3.0-3.0-3.1-2.2-2.4-2.9-2.6
Time in closed arm after self-admin5.55.88.4-1.9-2.6-2.7-2.9-2.7-2.4-2.6-2.6-1.9-2.6-2.6-2.6-2.41.7-2.9-2.3-2.5-2.4-2.0-1.6-2.2-2.4
Time in open arm before self-admin4.44.85.72.22.42.32.32.22.32.22.31.92.22.42.32.3-1.82.32.32.32.41.61.92.31.7
Time in open arm after self-admin9.910.812.53.23.43.53.53.43.43.43.43.53.33.43.33.2-3.23.43.13.33.23.42.83.03.0
Bone: periosteal estimation0.40.91.8-1.3-1.1-1.3-0.9-0.8-1.2-0.9-0.9-1.2-0.8-0.8-0.8-0.61.2-0.9-0.7-0.8-1.2-1.0-1.3-0.5-0.5
Bone: periosteal perimeter0.00.10.2-0.3-0.1-0.20.00.0-0.4-0.3-0.2-0.4-0.1-0.1-0.2-0.10.3-0.2-0.2-0.2-0.4-0.2-0.4-0.2-0.2
Bone: post-yield work2.13.03.61.71.91.81.81.91.51.71.81.51.81.81.91.9-1.51.91.81.81.51.71.61.71.5
Progressive ratio test 1 active lever presses0.40.40.9-0.4-0.7-0.7-0.5-0.5-0.8-0.8-0.7-0.4-0.7-0.7-0.8-0.60.5-0.8-0.7-0.7-0.2-1.0-0.0-0.7-0.9
Progressive ratio test 1 breakpoint0.40.50.9-0.5-0.7-0.7-0.5-0.6-0.8-0.8-0.7-0.4-0.8-0.7-0.8-0.70.5-0.9-0.7-0.8-0.3-1.0-0.0-0.7-0.9
Progressive ratio test 1 inactive lever presses1.21.72.21.31.31.21.31.41.31.21.31.31.31.31.21.4-1.31.31.41.41.51.21.41.51.0
Progressive ratio test 2 active lever presses0.50.61.3-0.5-0.8-0.8-0.7-0.6-0.7-0.9-0.8-0.4-0.9-0.9-1.0-0.70.6-1.1-0.6-0.8-0.4-1.2-0.6-0.6-1.1
Progressive ratio test 2 breakpoint0.50.51.1-0.4-0.7-0.8-0.7-0.6-0.6-0.8-0.7-0.4-0.8-0.9-0.9-0.60.6-1.0-0.6-0.7-0.4-1.0-0.6-0.6-1.0
Progressive ratio test 2 inactive lever presses0.10.10.7-0.2-0.2-0.4-0.3-0.1-0.3-0.4-0.2-0.0-0.3-0.3-0.4-0.10.5-0.3-0.0-0.20.1-0.9-0.20.0-0.7
Incentive Sensitization - Responses0.30.40.8-0.3-0.6-0.7-0.6-0.5-0.5-0.6-0.6-0.3-0.7-0.8-0.7-0.50.4-0.9-0.5-0.6-0.5-0.7-0.7-0.4-0.8
Incentive Sensitization - Breakpoint0.30.40.7-0.4-0.6-0.7-0.7-0.5-0.5-0.6-0.6-0.2-0.6-0.8-0.7-0.50.5-0.8-0.5-0.6-0.5-0.7-0.7-0.4-0.7
Sum of active levers in priming session hrs 5-61.01.01.30.91.01.11.21.21.01.01.00.91.01.01.00.9-0.91.00.80.90.71.10.90.81.0
Progressive ratio1.52.33.7-1.6-1.8-1.9-1.6-1.6-1.4-1.7-1.6-1.3-1.6-1.7-1.6-1.31.5-1.4-1.2-1.4-1.6-1.6-1.5-1.0-1.1
Food seeking constrained by brief footshock0.10.10.3-0.4-0.1-0.30.10.2-0.20.00.0-0.60.10.20.10.20.30.40.20.1-0.2-0.3-0.30.30.4
Seeking ratio, punishment vs. effort0.91.32.00.91.31.31.31.30.91.31.20.61.31.41.41.1-0.81.31.01.11.01.10.80.91.1
Retroperitoneal fat weight0.00.20.6-0.1-0.4-0.3-0.5-0.6-0.1-0.4-0.40.3-0.6-0.8-0.6-0.50.1-0.4-0.4-0.4-0.1-0.40.1-0.4-0.5
Reaction time number correct3.05.76.92.32.62.52.62.62.32.42.52.22.52.52.52.6-2.12.32.52.52.32.12.12.52.0
Reaction time mean minus median0.00.00.1-0.3-0.2-0.2-0.4-0.3-0.2-0.1-0.1-0.3-0.1-0.1-0.1-0.20.3-0.0-0.1-0.1-0.3-0.1-0.3-0.0-0.0
Reaction time mean minus median AUC0.00.00.1-0.4-0.2-0.2-0.3-0.3-0.2-0.1-0.1-0.4-0.1-0.0-0.0-0.10.40.1-0.0-0.1-0.2-0.1-0.30.00.1
Reaction time num false alarms1.72.42.81.61.61.61.61.51.61.61.61.51.61.51.51.6-1.51.61.61.61.71.41.51.61.2
Reaction time num false alarms AUC1.72.63.11.61.71.71.71.51.71.61.71.71.61.51.51.6-1.61.51.71.71.71.41.61.71.3
Reaction time trials correct on left3.05.76.92.32.62.52.62.62.32.42.52.22.52.52.52.6-2.12.32.52.52.32.12.12.52.0
Reaction time trials on left3.15.76.92.32.62.52.62.62.32.42.52.22.52.52.52.6-2.12.32.52.52.32.12.12.52.0
Reaction time mean1.72.73.7-1.8-1.8-1.8-1.9-1.9-1.5-1.6-1.7-1.6-1.7-1.8-1.6-1.61.6-1.6-1.5-1.5-1.6-1.5-1.6-1.3-1.3
Reaction time mean AUC1.01.62.3-1.5-1.4-1.4-1.5-1.5-1.2-1.2-1.2-1.3-1.3-1.3-1.2-1.21.4-1.2-1.1-1.1-1.2-1.2-1.4-1.0-1.0
Median of all reaction times1.82.63.5-1.8-1.8-1.8-1.9-1.8-1.5-1.6-1.6-1.5-1.7-1.8-1.6-1.61.6-1.6-1.4-1.5-1.5-1.6-1.5-1.2-1.2
Reaction time omissions0.10.20.70.20.30.20.30.20.40.40.50.20.40.50.40.6-0.30.30.70.60.30.20.20.80.5
Reaction time false alarm rate0.10.20.40.50.40.40.30.20.60.40.40.50.30.20.20.4-0.50.40.50.40.60.30.50.50.3
Reaction time premature initiation rate0.30.40.80.70.50.40.30.40.50.50.50.80.60.40.60.6-0.80.80.60.50.50.90.70.60.9
Reaction time premature initiations1.93.34.01.91.81.71.71.81.71.71.81.91.91.81.91.9-1.92.01.91.81.61.91.81.91.9
Std. dev. reaction times0.91.72.6-1.6-1.5-1.5-1.5-1.5-1.3-1.2-1.3-1.4-1.3-1.3-1.3-1.21.5-1.1-1.0-1.1-1.4-1.2-1.5-0.9-0.9
Reaction time trials completed3.15.76.92.32.62.52.62.62.32.42.52.22.52.52.52.6-2.12.32.52.52.32.12.12.52.0
Reaction time trials AUC3.16.07.12.42.62.52.72.72.42.52.62.32.52.52.52.6-2.22.42.62.62.42.12.22.52.0
Run reversals in cocaine runway, females1.61.62.5-1.6-1.4-1.5-1.4-1.3-1.3-1.4-1.3-1.4-1.2-1.1-1.1-1.21.3-1.0-1.2-1.2-1.2-1.2-1.3-1.1-0.7
Run reversals in cocaine runway, males0.10.10.4-0.2-0.2-0.2-0.3-0.1-0.2-0.2-0.1-0.5-0.2-0.1-0.2-0.10.2-0.5-0.1-0.1-0.3-0.6-0.5-0.0-0.4
Latency to leave start box in cocaine runway1.41.62.8-1.3-1.3-1.3-1.2-1.1-1.4-1.2-1.2-1.5-1.2-1.2-1.2-1.11.4-1.0-1.1-1.1-1.7-1.2-1.6-1.0-1.1
Latency to leave start box in cocaine runway, F0.60.71.3-0.7-0.8-0.8-0.8-0.7-0.9-0.9-0.8-0.7-0.9-0.8-0.9-0.80.7-1.0-0.8-0.8-1.1-0.7-0.9-0.8-0.9
Latency to leave start box in cocaine runway, M1.00.92.4-1.2-0.9-1.0-0.8-0.7-1.1-0.8-0.8-1.6-0.7-0.8-0.6-0.71.4-0.3-0.7-0.8-1.2-0.9-1.5-0.6-0.6
Std. dev. time between licks in bursts0.00.00.2-0.00.20.20.20.3-0.00.30.2-0.10.30.40.30.30.10.20.20.2-0.00.1-0.10.20.2
Total sessions with >9 infusions1.31.62.2-1.2-1.3-1.4-1.0-1.1-1.5-1.4-1.2-1.4-1.3-1.2-1.4-1.11.3-1.4-1.1-1.2-1.3-1.4-1.3-1.0-1.3
Short access day 1 total inactive lever presses0.00.10.50.1-0.1-0.1-0.2-0.1-0.2-0.3-0.2-0.2-0.2-0.1-0.3-0.10.2-0.3-0.1-0.2-0.1-0.2-0.1-0.1-0.7
Short access day 10 total inactive lever presses0.10.20.30.50.50.50.20.30.50.40.40.40.40.30.40.3-0.30.50.40.30.50.60.40.30.1
Short access day 1 total infusions0.20.30.5-0.5-0.5-0.6-0.3-0.4-0.6-0.6-0.4-0.7-0.5-0.4-0.6-0.30.6-0.6-0.3-0.3-0.5-0.7-0.7-0.2-0.6
Short access day 10 total infusions0.70.91.3-0.8-0.9-1.0-0.7-0.8-1.1-1.1-1.0-0.8-1.0-0.9-1.0-0.90.9-0.9-0.9-1.0-0.6-1.1-0.3-1.0-1.1
Short access total infusions1.41.83.0-1.5-1.3-1.4-1.1-1.1-1.6-1.4-1.3-1.5-1.3-1.3-1.4-1.11.6-1.4-1.1-1.2-1.2-1.7-1.3-1.1-1.4
Short access day 1 locomotion1.11.31.7-1.1-1.2-1.2-1.2-1.2-1.1-1.2-1.2-0.9-1.2-1.2-1.3-1.11.1-1.3-1.1-1.1-0.9-1.3-0.8-1.0-1.2
Short access day 10 total locomotion0.30.51.0-0.7-0.6-0.4-0.5-0.6-0.7-0.7-0.7-0.7-0.7-0.7-0.6-0.80.9-0.5-0.9-0.8-0.5-0.8-0.5-1.0-0.9
Short access total locomotion0.50.61.4-0.7-0.6-0.7-0.6-0.6-0.9-0.8-0.7-0.6-0.8-0.8-0.8-0.71.0-0.8-0.7-0.8-0.5-1.2-0.5-0.8-1.2
One hour access (0.3 mA shock)0.30.30.80.70.60.70.60.60.60.50.60.50.60.50.60.5-0.50.60.40.50.90.30.60.40.2
Compulsive drug intake1.62.03.01.61.61.71.41.41.61.41.41.71.41.31.41.3-1.51.31.21.31.21.71.01.01.1
One hour access (shock baseline)0.10.10.3-0.3-0.3-0.4-0.3-0.2-0.4-0.3-0.3-0.3-0.3-0.3-0.3-0.20.3-0.2-0.2-0.30.1-0.50.2-0.2-0.2
Social response proportion0.50.61.2-0.7-0.8-0.9-0.8-0.8-0.6-0.9-0.7-0.5-0.9-1.0-1.0-0.60.5-1.1-0.5-0.6-0.4-1.0-0.4-0.4-0.6
Social responses0.50.61.0-1.0-0.9-1.0-0.7-0.7-0.9-0.8-0.8-0.9-0.7-0.8-0.8-0.60.9-0.8-0.6-0.7-0.8-0.9-0.7-0.5-0.5
Social time0.10.10.4-0.6-0.4-0.6-0.3-0.3-0.2-0.2-0.1-0.4-0.2-0.3-0.30.10.3-0.20.30.1-0.1-0.5-0.30.50.1
Soleus weight2.16.18.52.72.82.92.72.72.42.62.52.42.62.82.62.3-2.42.42.12.22.42.52.31.91.8
Bone: stiffness0.61.01.50.91.00.91.11.20.71.01.00.81.11.11.11.1-0.81.11.01.00.71.00.91.01.0
Tibialis anterior weight0.82.63.81.61.71.71.61.81.51.71.61.41.82.01.81.6-1.51.71.41.51.61.61.51.31.3
Time to tail flick, vehicle, before self-admin0.80.91.51.11.11.10.91.10.81.01.00.51.01.11.00.9-0.61.20.90.80.90.91.10.80.4
Time to tail flick, vehicle, after self-admin0.00.00.1-0.20.30.30.10.20.00.20.2-0.20.20.30.20.10.30.20.00.10.1-0.3-0.2-0.0-0.0
Time to tail flick, test, before self-admin1.11.12.1-1.4-1.0-1.1-1.0-1.0-1.2-1.0-1.0-1.2-1.0-0.9-1.0-0.91.4-0.9-0.9-0.9-1.1-1.1-1.3-0.8-0.8
Time to tail flick, test, after self-admin2.22.33.21.71.51.61.21.51.41.61.51.61.51.51.51.5-1.81.41.51.51.41.71.61.41.4
Delta time to tail flick, vehicle, before/after SA0.20.20.80.10.40.50.50.40.40.50.50.60.50.50.50.4-0.40.30.40.50.50.40.30.40.9
Delta time to tail flick, test, before/after SA2.93.04.32.11.81.81.51.71.81.81.71.81.71.61.71.7-2.11.61.71.71.91.72.01.61.4
Tibia length0.10.40.80.80.70.60.50.50.70.50.70.80.50.50.40.6-0.90.40.70.70.80.40.90.70.4
Ambulatory time before self-admin0.50.71.6-0.5-0.7-0.6-0.8-0.7-0.9-0.8-0.9-0.9-0.8-0.8-0.8-0.90.7-1.0-1.0-1.0-0.7-0.8-0.5-1.1-1.3
Ambulatory time after self-admin0.10.10.3-0.1-0.2-0.3-0.3-0.2-0.4-0.3-0.2-0.3-0.2-0.3-0.3-0.2-0.1-0.4-0.2-0.2-0.50.20.3-0.2-0.2
Bone: tissue strength0.20.20.3-0.5-0.4-0.5-0.2-0.5-0.4-0.5-0.4-0.4-0.5-0.5-0.4-0.30.4-0.3-0.3-0.3-0.3-0.5-0.3-0.2-0.4
Total heroin consumption5.26.17.52.62.62.72.62.72.62.62.52.42.52.42.42.4-2.52.32.32.42.72.22.72.22.1
Bone: trabecular number0.30.50.90.70.70.70.70.70.60.80.70.60.80.70.90.7-0.60.90.70.70.60.80.60.70.8
Bone: trabecular spacing0.10.10.2-0.2-0.3-0.3-0.4-0.4-0.1-0.3-0.3-0.1-0.4-0.3-0.4-0.40.2-0.5-0.3-0.3-0.2-0.3-0.2-0.3-0.3
Bone: trabecular thickness0.00.00.10.30.10.1-0.1-0.00.20.10.10.20.0-0.00.1-0.0-0.3-0.00.00.00.20.10.30.00.1
Bone: trabecular tissue density0.00.00.1-0.0-0.2-0.1-0.2-0.20.0-0.2-0.2-0.1-0.2-0.2-0.2-0.20.1-0.3-0.2-0.2-0.0-0.2-0.0-0.3-0.3
Water consumed over 24 hours0.91.21.71.01.00.81.21.21.01.01.11.01.11.11.11.3-1.01.01.21.20.91.01.01.31.2
Number of responses in last shaping day0.10.10.3-0.5-0.4-0.4-0.2-0.3-0.6-0.3-0.3-0.5-0.3-0.3-0.3-0.20.4-0.3-0.2-0.3-0.4-0.2-0.5-0.2-0.2