Hub : Genes

Nucb2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Nucb2	0.8	0.09	0.0e+00	0.07	0.22	0.23	0.23	7.5e-08	1.4e-24	3.0e-25	7.3e-25
2	Liver	intron excision ratio	chr1_170756101_170769341	0.05	0.05	9.9e-04	0.01	0.01	0.01	0.01	7.2e-03	9.5e-03	1.6e-02	1.2e-02
3	Liver	intron excision ratio	chr1_170750971_170769341	0.03	0.03	1.6e-03	0.01	0.01	0	0.01	5.0e-02	2.7e-02	3.5e-01	2.6e-02
4	LHb	isoform ratio	XM_006230095.4	0.19	0.17	3.3e-03	0.08	0.08	0.07	0.07	5.2e-03	7.3e-03	1.2e-02	1.0e-02
5	LHb	isoform ratio	NM_021663.2	0.19	0.17	3.6e-03	0.08	0.07	0.06	0.07	5.6e-03	7.8e-03	1.3e-02	1.2e-02
6	Liver	isoform ratio	XM_006230095.4	0.03	0.03	6.3e-03	0.01	0.01	0	0	3.4e-02	3.4e-02	9.0e-02	7.2e-02
7	Liver	isoform ratio	NM_021663.2	0.04	0.03	2.6e-03	0.01	0.01	0.01	0.01	2.1e-02	1.8e-02	5.4e-02	4.4e-02
8	RMTg	alternative TSS	XM_006230095.4	0.09	0.09	7.0e-03	0.03	0.02	-0.01	-0	5.5e-02	8.5e-02	9.0e-01	3.9e-01
9	RMTg	alternative TSS	NM_021663.2	0.09	0.08	9.8e-03	0.02	0.01	-0.01	-0.01	7.8e-02	1.4e-01	9.5e-01	5.7e-01
10	Liver	mRNA stability	Nucb2	0.16	0.11	2.8e-13	0.07	0.07	0.07	0.07	2.7e-08	1.8e-08	1.1e-08	2.9e-08
11	NAcc	mRNA stability	Nucb2	0.02	0.03	6.6e-03	0.01	0.01	0.01	0.01	7.5e-03	6.1e-03	7.7e-03	6.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bone: apparent density	0.3	0.6	0.7	-0.8	-0.8	-0.8	-0.8	0.8	-0.8	0.8	-0.8	0.8	-0.6	0.0
Area under the delay curve	0.3	0.3	0.6	-0.5	0.7	0.7	0.8	-0.8	0.6	-0.6	0.5	-0.5	0.5	0.0
BMI with tail	5.4	17.4	20.6	-4.1	-4.5	-4.5	-4.5	4.5	-4.5	4.5	-4.3	4.3	-4.0	0.0
BMI without tail	10.4	21.5	29.3	-5.4	-4.9	-4.9	-4.8	4.8	-4.9	4.9	-4.8	4.8	-4.4	0.0
Body weight	4.4	18.6	22.5	-4.7	-4.7	-4.7	-4.7	4.7	-4.5	4.5	-4.3	4.3	-4.0	0.0
Weight adjusted by age	0.9	1.0	1.5	-1.2	-1.1	-1.1	-1.1	1.1	-1.1	1.1	-1.1	1.1	-0.5	0.0
Bone surface	0.7	1.2	1.7	-1.1	-1.1	-1.1	-1.1	1.1	-1.1	1.1	-1.3	1.3	-1.0	0.0
Bone volume	0.7	1.2	1.4	-1.2	-1.2	-1.2	-1.2	1.2	-1.1	1.1	-1.2	1.2	-1.0	0.0
Breakpoint value in progressive ratio session	6.1	6.7	17.3	4.2	2.1	2.1	2.3	-2.3	2.7	-2.7	2.8	-2.8	2.7	0.0
Number of licking bursts	5.4	6.3	7.6	2.2	2.8	2.8	2.8	-2.8	2.7	-2.7	2.6	-2.6	2.5	0.0
Context. condit. distance diff. score	0.7	0.9	1.5	1.1	1.0	1.0	1.0	-1.0	1.0	-1.0	0.8	-0.8	1.2	0.0
Locomotion velocity, session 1	2.6	2.8	3.5	1.5	1.9	1.9	1.9	-1.9	1.8	-1.8	1.6	-1.6	1.7	0.0
Locomotion distance, session 1	0.1	0.1	0.6	0.2	0.2	0.2	0.2	-0.2	0.3	-0.3	0.2	-0.2	0.8	0.0
Locomotion velocity, session 2	3.5	4.1	5.1	2.3	2.1	2.1	2.1	-2.1	2.1	-2.1	2.1	-2.1	2.0	0.0
Locomotion distance, session 2	0.1	0.1	0.3	0.2	0.3	0.3	0.3	-0.3	0.3	-0.3	0.3	-0.3	0.5	0.0
Locomotion velocity, session 3	0.0	0.0	0.0	0.1	0.0	0.0	0.0	-0.0	0.1	-0.1	0.1	-0.1	0.0	0.0
Locomotion distance, session 3	0.0	0.0	0.1	0.2	0.0	0.0	0.0	-0.0	0.2	-0.2	0.2	-0.2	-0.0	0.0
Stereotopy head waving bouts, day 3	1.2	1.4	2.4	1.5	1.3	1.3	1.3	-1.3	1.0	-1.0	0.9	-0.9	1.6	0.0
Stereotopy head waving duration, day 3	1.3	1.5	2.4	1.4	1.4	1.4	1.4	-1.4	1.1	-1.1	0.9	-0.9	1.5	0.0
Locomotion velocity, session 7	0.1	0.1	0.2	0.4	0.4	0.4	0.4	-0.4	0.2	-0.2	0.0	-0.0	-0.0	0.0
Locomotion distance, session 7	0.7	0.9	1.3	1.1	1.1	1.1	1.1	-1.1	1.0	-1.0	0.8	-0.8	0.6	0.0
Stereotopy head waving bouts, day 7	0.4	0.5	1.0	0.8	0.7	0.7	0.7	-0.7	0.6	-0.6	0.6	-0.6	1.0	0.0
Stereotopy head waving duration, day 7	0.1	0.2	0.3	-0.3	-0.4	-0.4	-0.4	0.4	-0.5	0.5	-0.5	0.5	-0.1	0.0
Locomotion velocity, session 8	1.8	2.1	2.9	1.2	1.5	1.5	1.5	-1.5	1.7	-1.7	1.7	-1.7	1.3	0.0
Locomotion distance, session 8	0.9	1.4	2.3	1.3	1.2	1.2	1.2	-1.2	1.2	-1.2	1.1	-1.1	1.5	0.0
Degree of sensitization distance	0.3	0.3	0.6	0.7	0.7	0.7	0.7	-0.7	0.5	-0.4	0.2	-0.2	0.7	0.0
Degree of sensitization stereotypy	0.1	0.1	0.2	0.4	0.2	0.2	0.2	-0.2	0.2	-0.2	0.3	-0.3	0.5	0.0
Conditioned locomotion	0.3	0.3	0.6	-0.5	0.5	0.5	0.5	-0.5	0.7	-0.7	0.8	-0.8	0.4	0.0
Cocaine response after cond. corrected	0.3	0.3	0.6	0.2	0.8	0.8	0.8	-0.8	0.4	-0.4	0.2	-0.2	0.5	0.0
Cocaine response after cond. not corrected	0.6	0.7	1.1	-1.0	-0.6	-0.6	-0.6	0.6	-0.9	0.9	-1.0	1.0	-0.9	0.0
Cocaine response before conditioning	5.0	6.0	7.6	-2.5	-2.7	-2.7	-2.7	2.7	-2.5	2.5	-2.3	2.3	-2.8	0.0
Saline control response	0.6	0.8	1.5	-1.2	-0.8	-0.8	-0.8	0.8	-0.9	0.9	-1.0	1.0	-0.7	0.0
Bone: connectivity density	0.7	1.1	1.7	-0.9	-1.1	-1.1	-1.1	1.1	-1.2	1.2	-1.3	1.3	-1.0	0.0
Bone: cortical apparent density	1.8	2.4	3.0	1.5	1.7	1.7	1.7	-1.7	1.6	-1.6	1.6	-1.6	1.4	0.0
Bone: cortical area	1.7	2.6	3.5	-1.7	-1.6	-1.6	-1.6	1.6	-1.8	1.8	-1.9	1.9	-1.4	0.0
Bone: cortical porosity	1.8	2.0	2.6	-1.5	-1.6	-1.6	-1.6	1.6	-1.4	1.4	-1.2	1.2	-1.5	0.0
Bone: cortical porosity	0.8	0.9	1.3	-1.1	-1.1	-1.1	-1.1	1.1	-0.9	0.9	-0.7	0.7	-0.9	0.0
Bone: cortical thickness	0.1	0.2	0.4	-0.3	-0.3	-0.3	-0.3	0.3	-0.5	0.5	-0.6	0.6	-0.3	0.0
Bone: cortical thickness	0.1	0.1	0.3	0.5	0.4	0.4	0.4	-0.4	0.3	-0.3	0.2	-0.2	0.3	0.0
Bone: cortical tissue density	1.9	2.5	3.1	1.5	1.8	1.8	1.8	-1.8	1.6	-1.6	1.6	-1.6	1.4	0.0
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	-0.3	-0.4	-0.4	-0.4	0.4	-0.3	0.3	-0.3	0.3	-0.0	0.0
Condit. Reinf. active-inactive response ratio	0.8	0.8	1.0	-0.9	-1.0	-1.0	-1.0	1.0	-1.0	1.0	-1.0	1.0	-0.6	0.0
Condit. Reinf. active responses	0.0	0.0	0.0	-0.1	-0.1	-0.1	-0.1	0.1	-0.1	0.1	-0.1	0.1	0.1	0.0
Condit. Reinf. inactive responses	0.0	0.0	0.1	-0.2	-0.2	-0.2	-0.2	0.2	-0.0	-0.0	0.1	-0.1	-0.2	0.0
Incentive salience index mean	0.3	0.3	0.6	-0.8	-0.7	-0.7	-0.7	0.7	-0.4	0.4	-0.3	0.3	-0.6	0.0
Condit. Reinf. lever presses	0.1	0.1	0.5	-0.7	-0.1	-0.1	-0.1	0.1	0.1	-0.1	0.2	-0.2	-0.4	0.0
Condit. Reinf. active minus inactive responses	1.0	1.2	1.7	-0.7	-1.3	-1.3	-1.3	1.3	-1.2	1.2	-1.1	1.1	-0.7	0.0
Condit. Reinf. active-inactive response ratio	0.6	0.6	0.9	-0.5	-0.9	-0.9	-0.9	0.9	-0.9	0.9	-0.9	0.9	-0.5	0.0
Condit. Reinf. active responses	0.8	1.1	1.9	-0.5	-1.4	-1.4	-1.4	1.4	-1.1	1.1	-0.9	0.9	-0.8	0.0
Condit. Reinf. inactive responses	0.7	0.8	1.2	-0.6	-1.1	-1.1	-1.1	1.1	-0.9	0.9	-0.7	0.7	-1.1	0.0
Condit. Reinf. lever presses	3.1	4.3	5.0	-1.9	-2.2	-2.2	-2.2	2.2	-2.2	2.2	-2.2	2.2	-1.7	0.0
Condit. Reinf. lever reinforcers received	0.7	1.0	1.5	-0.6	-1.2	-1.2	-1.2	1.2	-1.1	1.1	-0.9	0.9	-0.7	0.0
Conditioned reinforcement - actives	0.4	0.4	0.6	0.2	0.7	0.7	0.8	-0.8	0.7	-0.7	0.7	-0.7	0.8	0.0
Conditioned reinforcement - inactives	1.3	1.5	2.2	-1.2	1.1	1.1	1.1	-1.1	1.3	-1.4	1.5	-1.5	1.1	0.0
Conditioned locomotion	1.2	1.5	1.8	1.3	1.2	1.2	1.3	-1.3	1.2	-1.2	1.2	-1.2	1.3	0.0
Patch foraging indifference point 0 sec	0.6	0.9	7.2	-2.7	-0.2	-0.2	-0.2	0.2	-0.7	0.7	-1.0	1.0	0.2	0.0
Patch foraging indifference point AUC	1.0	1.2	1.8	-0.9	-1.2	-1.2	-1.2	1.2	-1.1	1.1	-1.0	1.0	-1.3	0.0
Delay disc. indifference point, 0s delay	0.3	0.3	2.4	-1.6	0.4	0.4	0.5	-0.5	0.2	-0.2	0.1	-0.1	-0.0	0.0
Delay disc. indifference point, 16s delay	4.2	4.3	5.1	1.6	2.2	2.2	2.2	-2.2	2.2	-2.2	2.2	-2.2	2.2	0.0
Delay disc. indifference point, 2s delay	0.8	0.9	4.7	-2.2	-0.7	-0.7	-0.6	0.6	-0.8	0.8	-0.8	0.8	-0.8	0.0
Delay disc. indifference point, 24s delay	1.9	1.8	2.4	0.1	1.5	1.5	1.5	-1.5	1.5	-1.5	1.5	-1.5	1.2	0.0
Delay disc. indifference point, 4s delay	0.3	0.4	0.6	-0.4	0.7	0.7	0.8	-0.8	0.6	-0.6	0.4	-0.4	0.6	0.0
Delay disc. indifference point, 8s delay	0.9	1.0	1.4	0.6	1.1	1.1	1.2	-1.2	1.0	-1.0	1.0	-1.0	0.9	0.0
Indifference point function ln k	0.1	0.1	0.2	-0.5	-0.3	-0.3	-0.3	0.3	-0.3	0.3	-0.4	0.4	0.0	0.0
Indifference point function log k	0.1	0.1	0.2	-0.5	-0.3	-0.3	-0.3	0.3	-0.3	0.3	-0.4	0.4	0.0	0.0
Patch foraging total patch changes 0 sec	0.9	1.4	8.2	-2.9	-0.5	-0.5	-0.5	0.5	-1.1	1.1	-1.4	1.4	-0.1	0.0
Patch foraging total patch changes 12 sec	0.1	0.1	0.2	-0.4	0.3	0.3	0.3	-0.3	-0.2	0.2	-0.5	0.5	0.2	0.0
Patch foraging total patch changes 18 sec	0.1	0.1	0.5	-0.7	0.3	0.3	0.3	-0.3	-0.0	0.0	-0.3	0.3	-0.0	0.0
Patch foraging total patch changes 24 sec	0.5	0.7	1.2	-0.3	-0.8	-0.8	-0.8	0.8	-1.0	1.0	-1.1	1.1	-0.6	0.0
Patch foraging total patch changes 6 sec	0.3	0.4	2.0	-1.4	0.6	0.6	0.6	-0.6	0.4	-0.4	0.3	-0.3	1.0	0.0
Patch foraging time to switch 0 sec	3.6	5.5	6.6	2.1	2.6	2.6	2.6	-2.6	2.6	-2.6	2.5	-2.5	2.1	0.0
Patch foraging water rate 0 sec	1.1	1.7	3.0	-1.7	-1.2	-1.2	-1.2	1.2	-1.5	1.5	-1.5	1.5	-1.0	0.0
Patch foraging water rate 12 sec	4.5	6.9	8.3	-2.2	-2.9	-2.9	-2.9	2.9	-2.9	2.9	-2.8	2.8	-2.5	0.0
Patch foraging water rate 18 sec	2.0	2.6	3.6	-0.7	-1.9	-1.9	-1.9	1.9	-1.7	1.7	-1.6	1.6	-1.6	0.0
Patch foraging water rate 24 sec	0.4	0.5	0.9	-0.6	-0.7	-0.7	-0.7	0.7	-0.8	0.8	-0.8	0.8	-0.9	0.0
Patch foraging water rate 6 sec	0.5	0.7	1.1	-0.1	-0.8	-0.8	-0.8	0.8	-1.0	1.0	-1.1	1.1	-0.7	0.0
Seeking ratio, delayed vs. immediate footshock	0.3	0.3	3.4	-1.8	-0.1	-0.1	-0.1	0.1	-0.1	0.1	-0.1	0.1	-0.3	0.0
Distance traveled before self-admin	1.1	1.1	4.3	2.1	1.0	1.0	1.1	-1.1	0.9	-0.9	0.8	-0.8	1.0	0.0
Distance traveled after self-admin	0.1	0.1	0.6	-0.8	0.1	0.1	0.0	-0.0	0.1	-0.1	0.1	-0.1	-0.4	0.0
Extensor digitorum longus weight	2.4	9.3	14.4	-2.9	-3.2	-3.2	-3.2	3.2	-3.2	3.2	-3.0	3.0	-3.8	0.0
Bone: elastic displacement	3.3	3.7	4.9	1.9	2.1	2.1	2.1	-2.1	2.0	-2.0	1.9	-1.9	2.2	0.0
Bone: elastic work	0.4	0.5	0.9	0.7	0.7	0.7	0.7	-0.7	0.7	-0.7	0.6	-0.6	1.0	0.0
Bone: endosteal estimation	1.4	3.0	3.9	-2.0	-1.8	-1.8	-1.8	1.8	-1.8	1.8	-1.8	1.8	-1.6	0.0
Bone: endosteal perimeter	0.8	1.6	2.1	-1.4	-1.4	-1.4	-1.4	1.4	-1.3	1.3	-1.3	1.3	-1.3	0.0
Epididymis fat weight	1.4	3.2	4.0	-1.8	-2.0	-2.0	-2.0	2.0	-2.0	2.0	-1.8	1.8	-1.4	0.0
Delta time in closed arm before/after self-admin	0.5	0.5	3.7	1.9	0.5	0.5	0.4	-0.4	0.4	-0.4	0.3	-0.3	0.3	0.0
Delta time in open arm before/after self-admin	3.0	2.9	3.8	-1.5	-1.8	-1.8	-1.7	1.7	-1.9	1.9	-1.9	1.9	-1.4	0.0
Diff in mean of infusions in LGA sessions	0.7	0.8	2.1	1.4	0.8	0.8	0.8	-0.8	0.8	-0.8	0.7	-0.7	1.4	0.0
Delay discount exponential model param	0.3	0.3	0.5	0.6	-0.7	-0.7	-0.7	0.7	-0.5	0.5	-0.5	0.5	-0.5	0.0
Extinction: sum of active levers before priming	0.6	0.6	1.2	1.1	0.6	0.6	0.6	-0.6	0.9	-1.0	1.0	-1.0	0.6	0.0
Active lever presses in extinction session 6	0.3	0.3	3.0	-1.7	-0.4	-0.4	-0.4	0.4	-0.1	0.1	0.0	-0.0	-0.0	0.0
Bone: final force	1.5	2.4	2.7	-1.6	-1.6	-1.6	-1.6	1.6	-1.6	1.6	-1.6	1.6	-1.5	0.0
Bone: final moment	1.1	1.9	2.1	-1.5	-1.5	-1.5	-1.5	1.5	-1.4	1.4	-1.4	1.4	-1.3	0.0
Food consumed during 24 hour testing period	0.0	0.0	0.1	0.1	-0.1	-0.1	-0.1	0.1	0.1	-0.1	0.1	-0.1	0.3	0.0
Glucose	0.0	0.0	0.1	0.2	0.2	0.2	0.2	-0.2	0.1	-0.1	0.1	-0.1	0.2	0.0
Heart weight	0.3	0.4	2.2	-1.5	-0.5	-0.5	-0.5	0.5	-0.5	0.5	-0.6	0.6	-0.3	0.0
Delay discount hyperbolic model param	0.2	0.3	0.6	0.8	-0.6	-0.6	-0.6	0.6	-0.4	0.4	-0.3	0.3	-0.4	0.0
Intermittent access intake day 1-15 change	0.9	0.9	1.6	0.7	0.8	0.8	0.9	-0.9	1.2	-1.2	1.3	-1.3	0.4	0.0
Intermittent access intake escalation	0.5	0.5	1.0	0.1	0.6	0.6	0.7	-0.7	0.9	-0.9	1.0	-1.0	0.2	0.0
Intermittent access intake escalation 2	0.3	0.3	0.7	-0.4	0.3	0.3	0.4	-0.4	0.7	-0.7	0.8	-0.8	-0.3	0.0
Intermitt. access day 1 inactive lever presses	0.2	0.2	1.0	-1.0	0.3	0.3	0.3	-0.3	0.4	-0.5	0.5	-0.5	-0.1	0.0
Intermitt. access day 15 inactive lever presses	0.6	0.6	2.6	1.6	0.7	0.7	0.6	-0.6	0.7	-0.7	0.7	-0.7	0.9	0.0
Intermitt. access escalation Index	2.3	2.0	2.8	-0.8	-1.5	-1.5	-1.6	1.6	-1.5	1.5	-1.5	1.5	-1.7	0.0
Intermittent access day 1 total infusions	0.4	0.4	1.0	1.0	-0.5	-0.5	-0.5	0.5	-0.8	0.8	-0.9	0.9	0.2	0.0
Intermittent access day 15 total infusions	0.1	0.1	1.4	1.2	-0.0	-0.0	0.0	-0.0	0.1	-0.1	0.1	-0.1	0.2	0.0
Intermittent access terminal intake (last 3 days)	0.5	0.5	5.1	2.3	-0.3	-0.3	-0.3	0.3	-0.1	0.1	-0.1	0.1	0.1	0.0
Intermittent access total infusions	0.2	0.3	0.6	0.4	-0.4	-0.4	-0.4	0.4	-0.6	0.6	-0.7	0.7	-0.0	0.0
Intermittent access day 1 locomotion	0.7	0.8	1.5	1.2	-0.9	-0.9	-0.8	0.8	-1.0	1.0	-1.0	1.0	-0.1	0.0
Intermittent access day 15 total locomotion	0.2	0.2	0.5	0.7	-0.6	-0.6	-0.6	0.6	-0.4	0.4	-0.4	0.4	0.1	0.0
Intermittent access total locomotion	0.6	0.7	1.0	0.6	-0.9	-0.9	-0.9	0.9	-1.0	1.0	-1.0	1.0	-0.1	0.0
Intermittent access standard deviation	0.7	0.7	4.1	-2.0	-0.7	-0.7	-0.7	0.7	-0.6	0.6	-0.5	0.5	-0.9	0.0
Left kidney weight	6.9	19.5	23.0	-4.6	-4.8	-4.8	-4.8	4.8	-4.5	4.5	-4.4	4.4	-4.7	0.0
Right kidney weight	7.7	21.7	26.6	-3.9	-5.2	-5.2	-5.1	5.1	-4.9	4.9	-4.7	4.7	-5.0	0.0
Cocaine induced anxiety	1.0	1.2	1.6	-1.1	-1.2	-1.2	-1.2	1.2	-1.1	1.0	-0.9	0.9	-1.2	0.0
Post-drug Anxiety	0.3	0.3	0.6	-0.5	-0.7	-0.7	-0.7	0.7	-0.5	0.5	-0.5	0.5	-0.8	0.0
Baseline Anxiety	1.3	1.4	1.7	1.3	1.3	1.3	1.3	-1.3	1.2	-1.2	1.2	-1.2	0.9	0.0
Tail length	2.5	7.5	17.0	-4.1	-2.8	-2.8	-2.7	2.7	-2.7	2.7	-2.7	2.7	-2.5	0.0
Length with tail	0.9	3.2	5.5	-2.4	-2.0	-2.0	-1.9	1.9	-1.8	1.8	-1.7	1.7	-1.5	0.0
Length without tail	0.2	0.4	0.9	0.9	0.5	0.5	0.5	-0.5	0.7	-0.7	0.9	-0.9	0.7	0.0
Times rat made contact with spout	0.5	0.5	0.7	0.6	0.8	0.8	0.8	-0.8	0.8	-0.8	0.7	-0.7	0.7	0.0
Lifetime Intake	0.5	0.6	1.2	0.0	-0.7	-0.7	-0.7	0.7	-1.0	1.0	-1.1	1.1	-0.2	0.0
Liver weight, left	2.4	3.9	5.7	-2.4	-2.2	-2.2	-2.3	2.3	-1.9	1.8	-1.5	1.5	-2.2	0.0
Liver weight, right	3.6	6.0	11.3	-3.4	-2.6	-2.6	-2.6	2.6	-2.4	2.4	-2.1	2.1	-2.6	0.0
Locomotor activity	0.3	0.5	0.7	-0.3	-0.8	-0.8	-0.8	0.8	-0.9	0.9	-0.7	0.7	-0.3	0.0
Locomotor testing distance	0.1	0.2	0.4	0.7	-0.4	-0.4	-0.4	0.4	-0.5	0.5	-0.4	0.4	0.2	0.0
Locomotor testing rearing	0.1	0.2	0.4	0.6	-0.4	-0.4	-0.4	0.4	-0.5	0.6	-0.6	0.6	0.0	0.0
Locomotion in novel chamber	4.9	6.1	7.1	-2.5	-2.6	-2.6	-2.6	2.6	-2.6	2.6	-2.7	2.7	-2.4	0.0
Locomotion in novel chamber post-restriction	0.2	0.3	0.5	-0.2	-0.7	-0.7	-0.6	0.6	-0.6	0.6	-0.5	0.5	0.1	0.0
Fecal boli incidents, locomotor time 1	0.9	0.9	9.9	-3.2	0.1	0.1	0.3	-0.3	0.2	-0.2	0.1	-0.1	-0.2	0.0
Change in fecal boli incidents, locomotor task	0.0	0.0	0.2	-0.1	0.1	0.1	0.1	-0.1	0.2	-0.2	0.2	-0.2	0.5	0.0
Time >=10cm from walls, locomotor time 1	1.0	1.0	3.1	1.8	0.9	0.9	0.8	-0.8	0.9	-0.9	1.0	-1.0	1.2	0.0
Bouts of movement, locomotor time 1	0.1	0.1	0.3	-0.5	0.1	0.1	0.2	-0.2	0.3	-0.3	0.4	-0.4	0.1	0.0
Total resting periods, locomotor time 1	0.5	0.5	0.9	0.6	0.6	0.6	0.7	-0.7	0.9	-0.9	1.0	-1.0	0.5	0.0
Rest time, locomotor task time 1	5.1	5.7	19.3	4.4	2.2	2.2	2.0	-2.0	2.3	-2.3	2.4	-2.4	1.7	0.0
Distance moved, locomotor task time 1	2.0	2.2	4.2	-2.0	-1.6	-1.6	-1.5	1.5	-1.6	1.6	-1.6	1.6	-0.9	0.0
Vertical activity count, locomotor time 1	0.4	0.4	2.6	-1.6	-0.4	-0.4	-0.3	0.3	-0.5	0.5	-0.6	0.6	-0.1	0.0
Time >=10cm from walls, locomotor time 2	0.2	0.3	2.3	1.5	-0.3	-0.3	-0.5	0.5	-0.0	0.0	0.1	-0.1	-0.2	0.0
Bouts of movement, locomotor time 2	0.4	0.4	0.6	0.0	-0.7	-0.7	-0.7	0.7	-0.8	0.8	-0.8	0.8	-0.7	0.0
Total resting periods, locomotor time 2	0.6	0.6	0.8	0.0	-0.8	-0.8	-0.8	0.8	-0.9	0.9	-0.9	0.9	-0.9	0.0
Rest time, locomotor task time 2	1.0	1.1	1.3	1.1	1.2	1.2	1.1	-1.1	1.1	-1.1	1.1	-1.1	1.0	0.0
Distance moved, locomotor task time 2	0.2	0.2	1.5	1.2	0.2	0.2	0.1	-0.1	0.3	-0.3	0.4	-0.4	0.2	0.0
Vertical activity count, locomotor time 2	0.7	0.7	1.0	0.4	0.9	0.9	1.0	-1.0	1.0	-1.0	0.9	-0.9	0.8	0.0
Light reinforcement 1	0.7	1.3	5.4	2.3	1.0	1.0	1.0	-1.0	0.9	-0.9	0.8	-0.8	1.1	0.0
Light reinforcement 2	0.3	0.4	0.8	0.8	0.6	0.6	0.6	-0.6	0.6	-0.6	0.5	-0.5	0.9	0.0
Bone: marrow area	1.3	2.8	3.7	-1.9	-1.7	-1.7	-1.7	1.7	-1.8	1.8	-1.8	1.8	-1.6	0.0
Bone: maximum diameter	2.1	3.9	4.8	-2.2	-2.1	-2.1	-2.1	2.1	-2.1	2.1	-2.1	2.1	-1.9	0.0
Bone: maximum force	1.1	1.9	2.3	-1.5	-1.5	-1.5	-1.5	1.5	-1.4	1.4	-1.4	1.4	-1.3	0.0
Bone: maximum moment	0.8	1.4	1.7	-1.3	-1.3	-1.3	-1.3	1.3	-1.2	1.2	-1.2	1.2	-1.0	0.0
Mean time between licks in bursts	0.9	1.2	2.3	-1.5	-1.4	-1.4	-1.4	1.4	-0.9	0.8	-0.5	0.5	-1.1	0.0
Mean num. licks in bursts	2.7	3.2	3.8	-1.6	-2.0	-2.0	-2.0	2.0	-1.9	1.9	-1.8	1.8	-1.7	0.0
Cd content in liver	0.9	1.0	1.3	1.1	1.0	1.0	1.0	-1.0	1.0	-1.0	1.0	-1.0	1.1	0.0
Co content in liver	1.4	1.6	2.6	1.3	1.4	1.4	1.4	-1.4	1.2	-1.2	1.1	-1.1	1.6	0.0
Cu content in liver	0.1	0.1	0.3	-0.5	-0.4	-0.4	-0.4	0.4	-0.4	0.4	-0.4	0.4	0.0	0.0
Fe content in liver	1.4	1.7	2.0	1.3	1.4	1.4	1.4	-1.4	1.4	-1.4	1.4	-1.4	1.2	0.0
K content in liver	1.0	1.0	1.6	-1.2	-1.3	-1.3	-1.3	1.3	-0.8	0.8	-0.6	0.6	-1.2	0.0
Mg content in liver	0.5	0.5	0.8	-0.9	-0.9	-0.9	-0.9	0.9	-0.5	0.5	-0.4	0.4	-0.6	0.0
Mn content in liver	0.7	0.8	1.9	-0.9	-1.1	-1.1	-1.1	1.1	-0.8	0.8	-0.6	0.6	-1.4	0.0
Na content in liver	1.3	1.3	2.0	-1.3	-1.3	-1.3	-1.3	1.3	-1.1	1.1	-1.0	1.0	-1.4	0.0
Rb content in liver	0.1	0.1	0.1	-0.4	-0.3	-0.3	-0.3	0.3	-0.2	0.2	-0.2	0.2	0.1	0.0
Se content in liver	0.3	0.3	0.7	-0.9	-0.7	-0.7	-0.7	0.7	-0.4	0.4	-0.3	0.3	-0.8	0.0
Sr content in liver	2.3	2.1	2.8	-1.4	-1.5	-1.5	-1.5	1.5	-1.5	1.5	-1.5	1.5	-1.7	0.0
Zn content in liver	0.9	1.0	1.3	-1.1	-1.1	-1.1	-1.1	1.1	-1.1	1.1	-1.0	1.0	-0.7	0.0
Bone: minimum diameter	0.6	1.1	1.5	-1.2	-1.0	-1.0	-1.0	1.0	-1.1	1.1	-1.2	1.2	-0.9	0.0
Time in familiar zone, hab. session 1	0.4	0.4	0.6	0.4	0.5	0.5	0.5	-0.5	0.7	-0.7	0.8	-0.8	0.7	0.0
Time in novel zone, hab. session 1	0.2	0.2	0.3	-0.2	-0.4	-0.4	-0.4	0.4	-0.5	0.5	-0.6	0.6	-0.4	0.0
Total zone transitions, hab. session 1	0.1	0.1	0.5	-0.7	-0.3	-0.3	-0.3	0.3	-0.2	0.2	-0.2	0.2	0.1	0.0
Total locomotion distance, hab. session 1	0.3	0.4	0.6	-0.8	-0.8	-0.8	-0.8	0.8	-0.7	0.7	-0.7	0.7	-0.0	0.0
Locomotion velocity, hab. session 1	0.4	0.5	0.7	-0.9	-0.8	-0.8	-0.8	0.8	-0.7	0.7	-0.7	0.7	-0.1	0.0
Time in familiar zone, hab. session 2	0.4	0.4	0.5	-0.7	-0.7	-0.7	-0.7	0.7	-0.6	0.6	-0.7	0.7	-0.3	0.0
Time in novel zone, hab. session 2	0.0	0.0	0.0	0.2	0.0	0.0	0.0	-0.0	-0.1	0.1	0.0	-0.0	-0.2	0.0
Total zone transitions, hab. session 2	0.1	0.2	0.8	-0.9	-0.5	-0.5	-0.5	0.5	-0.3	0.2	-0.2	0.2	0.1	0.0
Total locomotion distance, hab. session 2	0.0	0.1	0.3	-0.6	-0.2	-0.2	-0.2	0.2	0.1	-0.1	0.2	-0.2	0.3	0.0
Locomotion velocity, hab. session 2	0.0	0.1	0.3	-0.6	-0.2	-0.2	-0.2	0.2	0.1	-0.1	0.2	-0.2	0.4	0.0
Novel to familiar place preference ratio	0.4	0.4	0.8	0.6	0.5	0.5	0.5	-0.5	0.8	-0.8	0.9	-0.9	0.8	0.0
Novelty place preference	0.7	0.8	1.4	0.8	0.7	0.7	0.7	-0.7	1.0	-1.0	1.2	-1.2	0.9	0.0
Time in novel zone, NPP test	0.6	0.6	1.1	0.7	0.6	0.6	0.6	-0.6	0.9	-0.9	1.0	-1.0	0.9	0.0
Total zone transitions, NPP test	0.0	0.0	0.1	0.0	-0.2	-0.2	-0.2	0.2	-0.2	0.2	-0.2	0.2	0.0	0.0
Total locomotion distance, NPP test	0.1	0.1	0.2	0.5	0.2	0.2	0.2	-0.2	0.3	-0.3	0.3	-0.3	0.5	0.0
Locomotion velocity, NPP test	0.0	0.1	0.2	0.4	0.2	0.2	0.2	-0.2	0.2	-0.2	0.2	-0.2	0.3	0.0
Intraocular pressure	0.4	0.6	1.6	-1.3	-0.6	-0.6	-0.6	0.6	-0.8	0.8	-0.9	0.9	-0.9	0.0
Delta distance traveled before/after self-admin	1.4	1.5	8.6	-2.9	-0.9	-0.9	-1.0	1.0	-0.9	0.9	-0.8	0.8	-1.2	0.0
Delta ambulatory time before/after self-admin	1.2	1.3	9.7	-3.1	-0.6	-0.6	-0.7	0.7	-0.6	0.6	-0.5	0.5	-1.0	0.0
Parametrial fat weight	9.4	18.3	22.2	-3.7	-4.6	-4.6	-4.7	4.7	-4.5	4.5	-4.4	4.4	-4.6	0.0
Pavlov. Cond. lever latency	1.6	2.0	3.2	1.6	1.5	1.5	1.5	-1.5	1.4	-1.4	1.3	-1.3	1.8	0.0
Pavlov. Cond. magazine entry latency	6.2	8.0	10.0	-3.0	-3.0	-3.0	-3.0	3.0	-2.9	2.9	-2.8	2.8	-3.2	0.0
Pavlov. Cond. change in total contacts	2.6	2.7	5.3	-1.8	-1.6	-1.6	-1.6	1.6	-1.6	1.6	-1.6	1.6	-2.3	0.0
Pavlov. Cond. index score	4.7	6.0	8.7	-2.8	-2.6	-2.6	-2.6	2.6	-2.4	2.4	-2.3	2.3	-2.9	0.0
Pavlov. Cond. latency score	4.5	5.7	8.3	-2.7	-2.5	-2.5	-2.5	2.5	-2.4	2.4	-2.3	2.3	-2.9	0.0
Pavlov. Cond. lever contacts	3.1	3.7	5.8	-2.3	-2.0	-2.0	-2.0	2.0	-1.9	1.9	-1.8	1.8	-2.4	0.0
Pavlov. Cond. magazine entry number	3.9	4.8	7.5	2.5	2.3	2.3	2.3	-2.3	2.2	-2.2	2.1	-2.1	2.7	0.0
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.9	0.8	0.6	0.6	0.6	-0.6	0.6	-0.6	0.6	-0.6	0.9	0.0
Pavlov. Cond. lever-magazine prob. diff.	5.3	6.6	9.1	-2.9	-2.7	-2.7	-2.7	2.7	-2.6	2.6	-2.5	2.5	-3.0	0.0
Pavlov. Cond. response bias	3.1	3.8	6.4	-2.4	-2.1	-2.1	-2.1	2.1	-1.9	1.9	-1.7	1.7	-2.5	0.0
Pavlov. Cond. lever latency	1.7	2.3	3.2	1.5	1.6	1.6	1.6	-1.6	1.7	-1.7	1.8	-1.8	1.0	0.0
Pavlov. Cond. magazine entry latency	0.0	0.0	0.2	-0.0	-0.1	-0.1	-0.1	0.1	-0.1	0.1	-0.0	0.0	-0.5	0.0
Pavlov. Cond. change in total contacts	0.5	0.6	0.9	-0.5	-0.9	-0.9	-0.9	0.9	-1.0	1.0	-0.9	0.9	-0.3	0.0
Pavlov. Cond. index score	0.6	0.7	1.0	-0.6	-0.9	-0.9	-0.9	0.9	-1.0	1.0	-1.0	1.0	-0.7	0.0
Pavlov. Cond. latency score	0.5	0.7	0.9	-0.5	-0.8	-0.8	-0.8	0.8	-0.9	1.0	-1.0	1.0	-0.8	0.0
Pavlov. Cond. lever contacts	3.4	4.6	6.1	-2.2	-2.2	-2.2	-2.2	2.2	-2.4	2.4	-2.5	2.5	-1.7	0.0
Pavlov. Cond. magazine entry number	0.3	0.4	0.6	-0.8	-0.7	-0.7	-0.7	0.7	-0.7	0.7	-0.7	0.7	-0.5	0.0
Pavlov. Cond. intertrial magazine entries	6.4	8.3	10.2	-3.1	-3.2	-3.2	-3.2	3.2	-3.0	2.9	-2.7	2.7	-3.0	0.0
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.7	0.9	-0.6	-0.8	-0.8	-0.8	0.8	-0.9	0.9	-0.9	0.9	-0.7	0.0
Pavlov. Cond. response bias	1.3	1.8	2.3	-1.4	-1.4	-1.4	-1.4	1.4	-1.5	1.5	-1.5	1.5	-1.0	0.0
Time in closed arm before self-admin	1.2	1.4	7.9	-2.8	-0.9	-0.9	-0.9	0.9	-1.0	1.0	-1.0	1.0	-0.8	0.0
Time in closed arm after self-admin	0.7	0.7	3.3	1.8	0.9	0.9	0.8	-0.8	0.6	-0.6	0.5	-0.5	0.9	0.0
Time in open arm before self-admin	1.6	1.7	12.4	3.5	0.8	0.8	0.8	-0.8	1.0	-1.0	1.0	-1.0	0.7	0.0
Time in open arm after self-admin	1.9	2.0	3.0	-1.3	-1.7	-1.7	-1.6	1.6	-1.4	1.4	-1.3	1.3	-1.6	0.0
Bone: periosteal estimation	2.0	4.2	5.6	-2.3	-2.0	-2.0	-2.0	2.0	-2.3	2.3	-2.4	2.4	-1.9	0.0
Bone: periosteal perimeter	2.1	3.6	4.4	-2.0	-1.9	-1.9	-1.9	1.9	-2.1	2.1	-2.1	2.1	-1.7	0.0
Bone: post-yield work	3.8	5.2	6.4	-2.2	-2.5	-2.5	-2.5	2.5	-2.5	2.5	-2.4	2.4	-1.9	0.0
Progressive ratio test 1 active lever presses	0.3	0.3	0.6	-0.7	-0.4	-0.4	-0.3	0.3	-0.7	0.7	-0.8	0.8	0.1	0.0
Progressive ratio test 1 breakpoint	0.4	0.5	1.0	-1.0	-0.5	-0.5	-0.5	0.5	-0.8	0.8	-0.9	0.9	-0.1	0.0
Progressive ratio test 1 inactive lever presses	0.7	0.8	5.3	-2.3	-0.6	-0.6	-0.5	0.5	-0.7	0.7	-0.7	0.7	0.0	0.0
Progressive ratio test 2 active lever presses	0.1	0.1	0.2	0.2	0.1	0.1	0.1	-0.1	-0.3	0.3	-0.4	0.4	0.5	0.0
Progressive ratio test 2 breakpoint	0.1	0.1	0.2	0.0	-0.0	-0.0	0.0	-0.0	-0.3	0.3	-0.4	0.4	0.5	0.0
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.7	-0.2	0.3	0.3	0.3	-0.3	0.2	-0.2	0.1	-0.1	0.8	0.0
Incentive Sensitization - Responses	0.5	0.5	1.2	0.6	0.8	0.8	0.9	-0.9	0.6	-0.6	0.6	-0.6	1.1	0.0
Incentive Sensitization - Breakpoint	0.6	0.6	1.3	0.8	0.8	0.8	0.8	-0.8	0.7	-0.7	0.6	-0.6	1.1	0.0
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	0.3	-0.1	-0.1	-0.1	0.1	0.1	-0.1	0.1	-0.1	0.3	0.0
Progressive ratio	0.1	0.1	0.4	0.6	-0.0	-0.0	-0.1	0.1	0.2	-0.2	0.2	-0.2	0.5	0.0
Food seeking constrained by brief footshock	0.6	0.7	1.0	-0.5	0.8	0.8	0.8	-0.8	1.0	-1.0	1.0	-1.0	0.8	0.0
Seeking ratio, punishment vs. effort	0.2	0.2	2.1	-1.5	-0.1	-0.1	0.0	-0.0	-0.1	0.1	-0.2	0.2	-0.4	0.0
Retroperitoneal fat weight	2.3	7.6	9.9	-1.5	-3.1	-3.1	-3.1	3.1	-3.1	3.1	-2.8	2.8	-2.7	0.0
Reaction time number correct	0.2	0.3	0.6	0.1	-0.6	-0.6	-0.6	0.6	-0.6	0.6	-0.5	0.5	-0.8	0.0
Reaction time mean minus median	0.7	0.9	3.2	-1.8	-1.0	-1.0	-1.0	1.0	-0.8	0.8	-0.7	0.7	-0.9	0.0
Reaction time mean minus median AUC	1.0	1.3	5.7	-2.4	-1.2	-1.2	-1.2	1.2	-0.9	0.9	-0.7	0.7	-1.0	0.0
Reaction time num false alarms	0.2	0.3	0.6	-0.5	0.6	0.6	0.6	-0.6	0.7	-0.7	0.8	-0.8	0.1	0.0
Reaction time num false alarms AUC	0.2	0.3	1.4	-1.2	0.2	0.2	0.2	-0.2	0.4	-0.5	0.6	-0.6	-0.2	0.0
Reaction time trials correct on left	0.2	0.3	0.6	0.1	-0.6	-0.6	-0.6	0.6	-0.6	0.6	-0.5	0.5	-0.8	0.0
Reaction time trials on left	0.3	0.4	0.6	0.1	-0.7	-0.7	-0.7	0.7	-0.7	0.7	-0.6	0.6	-0.8	0.0
Reaction time mean	0.2	0.2	0.3	-0.6	-0.5	-0.5	-0.5	0.5	-0.5	0.5	-0.5	0.5	-0.3	0.0
Reaction time mean AUC	0.1	0.1	0.2	-0.4	-0.3	-0.3	-0.3	0.3	-0.3	0.3	-0.3	0.3	-0.2	0.0
Median of all reaction times	0.0	0.0	0.1	0.2	-0.1	-0.1	-0.1	0.1	-0.2	0.2	-0.3	0.3	0.1	0.0
Reaction time omissions	0.0	0.0	0.2	-0.4	-0.2	-0.2	-0.2	0.2	-0.3	0.3	-0.2	0.2	0.2	0.0
Reaction time false alarm rate	0.4	0.6	1.0	-0.8	0.7	0.7	0.7	-0.7	0.9	-0.9	1.0	-1.0	0.3	0.0
Reaction time premature initiation rate	0.2	0.2	2.0	1.4	-0.2	-0.2	-0.2	0.2	-0.1	0.1	-0.2	0.2	-0.4	0.0
Reaction time premature initiations	0.2	0.3	1.9	1.4	-0.4	-0.4	-0.4	0.4	-0.2	0.2	-0.3	0.3	-0.7	0.0
Std. dev. reaction times	0.8	1.1	3.0	-1.7	-1.1	-1.1	-1.1	1.1	-1.1	1.1	-0.9	0.9	-0.9	0.0
Reaction time trials completed	0.3	0.4	0.6	0.1	-0.7	-0.7	-0.7	0.7	-0.7	0.7	-0.6	0.6	-0.8	0.0
Reaction time trials AUC	0.4	0.5	0.8	-0.1	-0.8	-0.8	-0.8	0.8	-0.8	0.8	-0.7	0.7	-0.9	0.0
Run reversals in cocaine runway, females	1.7	1.7	3.7	0.0	-1.4	-1.4	-1.3	1.3	-1.3	1.3	-1.4	1.4	-1.9	0.0
Run reversals in cocaine runway, males	2.6	2.5	6.3	-2.5	1.6	1.6	1.6	-1.6	1.5	-1.5	1.4	-1.4	1.5	0.0
Latency to leave start box in cocaine runway	0.5	0.6	5.6	2.4	0.4	0.4	0.4	-0.4	0.2	-0.2	0.1	-0.1	0.4	0.0
Latency to leave start box in cocaine runway, F	0.5	0.6	5.3	2.3	-0.3	-0.3	-0.3	0.3	-0.3	0.3	-0.3	0.3	-0.4	0.0
Latency to leave start box in cocaine runway, M	2.1	2.0	4.7	2.2	1.5	1.5	1.5	-1.5	1.3	-1.3	1.2	-1.2	1.5	0.0
Std. dev. time between licks in bursts	2.5	3.0	3.8	-1.9	-1.9	-1.9	-1.9	1.9	-1.7	1.7	-1.6	1.6	-1.9	0.0
Total sessions with >9 infusions	0.8	0.9	3.0	-1.7	-0.8	-0.8	-0.6	0.6	-1.0	1.1	-1.2	1.2	-0.6	0.0
Short access day 1 total inactive lever presses	0.5	0.6	4.7	-2.2	0.5	0.5	0.6	-0.6	0.2	-0.2	0.1	-0.1	0.7	0.0
Short access day 10 total inactive lever presses	0.6	0.7	0.9	-0.4	0.9	0.9	0.9	-0.9	0.9	-0.9	1.0	-1.0	0.8	0.0
Short access day 1 total infusions	0.5	0.6	1.1	-1.1	-0.6	-0.6	-0.5	0.5	-0.9	0.9	-1.0	1.0	-0.1	0.0
Short access day 10 total infusions	0.2	0.2	0.5	-0.4	-0.3	-0.3	-0.3	0.3	-0.6	0.6	-0.7	0.7	0.1	0.0
Short access total infusions	1.2	1.3	2.4	-1.1	-1.0	-1.0	-1.0	1.0	-1.4	1.4	-1.5	1.5	-0.5	0.0
Short access day 1 locomotion	0.1	0.1	0.4	-0.2	0.3	0.3	0.4	-0.4	0.0	-0.0	-0.1	0.1	0.6	0.0
Short access day 10 total locomotion	1.5	1.7	2.7	-1.6	-1.4	-1.4	-1.4	1.4	-1.4	1.4	-1.3	1.3	-0.9	0.0
Short access total locomotion	1.8	1.8	2.7	-1.4	-1.4	-1.4	-1.3	1.3	-1.6	1.6	-1.7	1.7	-0.7	0.0
One hour access (0.3 mA shock)	1.0	1.2	1.9	-0.2	-1.4	-1.4	-1.4	1.4	-1.1	1.1	-1.0	1.0	-1.1	0.0
Compulsive drug intake	1.4	1.4	2.3	0.2	-1.3	-1.3	-1.5	1.5	-1.2	1.2	-1.2	1.2	-1.1	0.0
One hour access (shock baseline)	0.2	0.2	0.4	0.1	0.3	0.3	0.4	-0.4	0.6	-0.6	0.6	-0.6	0.4	0.0
Social response proportion	0.7	0.7	1.0	-0.6	-1.0	-1.0	-1.0	1.0	-1.0	1.0	-0.9	0.9	-0.5	0.0
Social responses	0.4	0.4	1.2	-0.7	0.7	0.7	0.7	-0.7	0.6	-0.6	0.5	-0.5	1.1	0.0
Social time	0.6	0.8	2.2	1.5	0.6	0.6	0.6	-0.6	1.0	-1.0	1.1	-1.1	1.0	0.0
Soleus weight	1.0	2.9	3.4	-1.7	-1.8	-1.8	-1.8	1.8	-1.8	1.8	-1.7	1.7	-1.9	0.0
Bone: stiffness	0.8	1.2	1.4	-1.2	-1.1	-1.1	-1.1	1.1	-1.1	1.1	-1.2	1.2	-1.1	0.0
Tibialis anterior weight	3.9	13.3	16.3	-4.0	-3.8	-3.8	-3.8	3.8	-3.8	3.8	-3.7	3.7	-3.8	0.0
Time to tail flick, vehicle, before self-admin	1.2	1.2	7.1	-2.7	-1.1	-1.1	-0.8	0.8	-0.7	0.7	-0.6	0.6	-0.9	0.0
Time to tail flick, vehicle, after self-admin	0.6	0.6	0.9	-0.2	0.8	0.8	0.9	-0.9	0.9	-0.9	0.9	-0.9	0.8	0.0
Time to tail flick, test, before self-admin	0.5	0.5	5.0	-2.2	0.2	0.2	0.1	-0.1	0.0	-0.0	-0.1	0.1	-0.0	0.0
Time to tail flick, test, after self-admin	0.1	0.1	0.3	-0.6	-0.3	-0.3	-0.1	0.1	-0.2	0.2	-0.2	0.2	-0.4	0.0
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.9	1.0	0.3	0.3	0.3	-0.3	-0.0	0.0	-0.2	0.2	0.4	0.0
Delta time to tail flick, test, before/after SA	0.9	0.8	5.4	2.3	-0.9	-0.9	-0.5	0.5	-0.6	0.6	-0.6	0.6	-0.5	0.0
Tibia length	0.0	0.1	0.4	-0.6	-0.3	-0.3	-0.3	0.3	-0.1	0.1	-0.1	0.1	-0.1	0.0
Ambulatory time before self-admin	1.8	1.9	4.3	2.1	1.4	1.4	1.5	-1.5	1.3	-1.3	1.2	-1.2	1.4	0.0
Ambulatory time after self-admin	0.2	0.2	0.9	-0.9	0.4	0.4	0.5	-0.5	0.4	-0.4	0.4	-0.4	-0.1	0.0
Bone: tissue strength	0.2	0.2	0.5	0.4	0.3	0.3	0.3	-0.3	0.6	-0.6	0.7	-0.7	0.3	0.0
Total heroin consumption	2.4	2.8	5.5	2.3	1.4	1.4	1.4	-1.4	1.8	-1.8	1.9	-1.9	2.0	0.0
Bone: trabecular number	0.0	0.0	0.0	0.1	0.0	0.0	0.0	-0.0	0.1	-0.1	0.0	-0.0	0.1	0.0
Bone: trabecular spacing	0.4	0.5	1.0	-0.8	-0.7	-0.7	-0.7	0.7	-0.7	0.7	-0.7	0.7	-1.0	0.0
Bone: trabecular thickness	0.6	0.7	0.9	-0.9	-0.9	-0.9	-0.9	0.9	-0.9	0.9	-0.8	0.8	-0.5	0.0
Bone: trabecular tissue density	0.2	0.3	0.4	0.4	0.6	0.6	0.6	-0.6	0.6	-0.6	0.6	-0.6	0.5	0.0
Water consumed over 24 hours	3.4	4.1	4.9	2.1	2.2	2.2	2.2	-2.2	2.2	-2.2	2.2	-2.2	1.7	0.0
Number of responses in last shaping day	0.1	0.1	0.1	0.0	-0.2	-0.2	-0.0	0.0	-0.3	0.3	-0.4	0.4	-0.2	0.0