Hub : Genes

Nucb2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver intron excision ratio chr1_180190391_180203629 0.06 0.06 1.3e-03 0.01 0.01 0.01 0.01 9.7e-03 1.4e-02 2.9e-02 2.0e-02
2 Liver intron excision ratio chr1_180185261_180203629 0.03 0.03 1.8e-03 0.01 0.01 0 0.01 3.8e-02 3.0e-02 9.6e-02 2.4e-02
3 NAcc gene expression Nucb2 0.02 0.02 5.4e-03 0 0.01 0 0 6.4e-02 3.8e-02 3.0e-01 1.7e-01
4 Liver isoform ratio XM_006230095.5 0.03 0.03 5.0e-03 0.01 0.01 0 0.01 2.6e-02 2.5e-02 1.8e-01 5.4e-02
5 Liver isoform ratio NM_021663.2 0.04 0.04 1.7e-03 0.01 0.01 0.01 0.01 1.2e-02 8.0e-03 3.7e-02 1.9e-02
6 NAcc mRNA stability Nucb2 0.03 0.02 3.7e-04 0.02 0.02 0.01 0.02 5.8e-04 9.4e-04 1.8e-03 1.2e-03
7 Liver mRNA stability Nucb2 0.16 0.11 1.9e-13 0.07 0.07 0.08 0.07 7.5e-08 1.2e-08 4.5e-09 3.0e-08
8 Liver gene expression Nucb2 0.78 0.1 0.0e+00 0.07 0.23 0.24 0.23 3.7e-08 4.5e-25 7.8e-26 2.6e-25

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.61.01.21.1-1.11.0-1.01.01.10.90.6
Area under the delay curve0.30.40.6-0.70.8-0.60.6-0.6-0.6-0.60.2
BMI with tail9.432.336.66.1-6.06.0-6.06.05.85.63.8
BMI without tail7.823.727.05.0-5.05.2-5.25.25.14.63.4
Body weight5.725.129.15.4-5.35.3-5.35.35.24.53.6
Weight adjusted by age0.71.12.11.1-1.11.0-1.01.00.90.61.4
Bone surface0.81.41.91.2-1.21.3-1.31.31.41.10.5
Bone volume0.91.62.01.4-1.41.3-1.31.31.41.20.7
Breakpoint value in progressive ratio session3.54.25.3-1.71.7-2.32.3-2.3-2.3-1.7-1.9
Number of licking bursts5.28.518.3-2.72.7-2.72.7-2.7-2.8-2.4-4.3
Context. condit. distance diff. score0.80.91.4-0.90.9-1.01.0-1.0-1.2-1.2-0.3
Locomotion velocity, session 12.93.13.7-1.91.9-1.81.8-1.8-1.7-1.7-1.1
Locomotion distance, session 10.10.10.4-0.20.2-0.20.2-0.2-0.4-0.70.1
Locomotion velocity, session 23.23.74.3-2.12.1-2.02.0-2.0-1.9-1.9-1.3
Locomotion distance, session 20.00.10.2-0.20.2-0.20.2-0.2-0.3-0.4-0.1
Locomotion velocity, session 30.00.00.00.0-0.0-0.10.1-0.1-0.00.00.0
Locomotion distance, session 30.00.00.0-0.10.1-0.20.2-0.2-0.10.00.0
Stereotopy head waving bouts, day 31.21.42.4-1.31.3-1.11.1-1.1-1.2-1.5-0.4
Stereotopy head waving duration, day 31.11.42.2-1.41.4-1.01.0-1.0-1.2-1.5-0.5
Locomotion velocity, session 70.10.10.2-0.40.4-0.10.1-0.1-0.10.1-0.4
Locomotion distance, session 70.81.01.3-1.11.1-1.01.0-1.0-0.9-0.7-0.7
Stereotopy head waving bouts, day 70.70.81.6-1.01.0-0.90.8-0.8-0.7-1.3-0.3
Stereotopy head waving duration, day 70.20.20.40.4-0.40.6-0.60.60.70.20.3
Locomotion velocity, session 81.82.22.8-1.51.5-1.71.7-1.7-1.5-1.3-0.9
Locomotion distance, session 81.01.42.0-1.21.2-1.21.2-1.2-1.4-1.4-0.6
Degree of sensitization distance0.40.40.6-0.80.8-0.50.5-0.5-0.5-0.8-0.5
Degree of sensitization stereotypy0.00.00.2-0.20.2-0.20.1-0.10.1-0.40.1
Conditioned locomotion0.50.50.8-0.60.6-0.90.9-0.9-0.6-0.5-0.7
Cocaine response after cond. corrected0.20.20.4-0.60.6-0.40.3-0.3-0.6-0.5-0.5
Cocaine response after cond. not corrected0.60.81.00.8-0.81.0-1.01.00.90.90.2
Cocaine response before conditioning5.06.07.22.6-2.62.5-2.52.52.72.71.3
Saline control response0.30.40.80.6-0.60.7-0.70.70.90.50.5
Bone: connectivity density1.11.82.21.3-1.31.5-1.51.51.51.30.7
Bone: cortical apparent density2.53.54.2-2.12.1-1.91.9-1.9-2.0-1.7-1.2
Bone: cortical area1.52.32.91.5-1.51.7-1.71.71.61.30.8
Bone: cortical porosity1.71.82.41.5-1.51.3-1.31.31.31.31.0
Bone: cortical porosity0.80.91.31.1-1.10.9-0.90.90.90.80.8
Bone: cortical thickness0.00.10.10.1-0.10.3-0.30.30.30.10.1
Bone: cortical thickness0.10.10.1-0.30.3-0.20.2-0.2-0.3-0.3-0.1
Bone: cortical tissue density2.53.44.1-2.02.0-1.91.9-1.9-2.0-1.7-1.2
Condit. Reinf. active minus inactive responses0.10.10.20.4-0.40.3-0.30.30.20.10.0
Condit. Reinf. active-inactive response ratio0.70.71.01.0-1.00.9-0.90.90.90.70.3
Condit. Reinf. active responses0.00.00.00.1-0.10.0-0.00.00.0-0.1-0.0
Condit. Reinf. inactive responses0.00.00.10.2-0.20.0-0.00.00.10.20.4
Incentive salience index mean0.20.30.50.7-0.70.4-0.40.40.40.6-0.1
Condit. Reinf. lever presses0.00.00.20.2-0.2-0.00.0-0.0-0.00.4-0.2
Condit. Reinf. active minus inactive responses1.11.51.91.4-1.41.3-1.31.31.10.81.0
Condit. Reinf. active-inactive response ratio0.70.81.01.0-1.01.0-1.01.00.90.60.5
Condit. Reinf. active responses1.11.52.11.4-1.41.2-1.21.21.10.91.1
Condit. Reinf. inactive responses0.81.01.31.1-1.10.9-0.90.90.91.10.9
Condit. Reinf. lever presses3.95.36.42.4-2.42.4-2.42.42.52.01.6
Condit. Reinf. lever reinforcers received0.91.31.61.3-1.31.2-1.21.21.00.81.1
Conditioned reinforcement - actives0.50.91.4-0.91.0-1.01.0-1.0-0.8-1.2-0.6
Conditioned reinforcement - inactives1.11.62.2-1.11.2-1.41.5-1.5-1.2-1.40.3
Conditioned locomotion1.51.92.1-1.31.3-1.51.5-1.5-1.2-1.3-1.4
Patch foraging indifference point 0 sec0.20.30.70.2-0.20.6-0.60.70.5-0.20.9
Patch foraging indifference point AUC0.81.11.31.1-1.11.0-1.01.01.21.11.2
Delay disc. indifference point, 0s delay0.00.00.3-0.10.2-0.00.0-0.0-0.00.10.5
Delay disc. indifference point, 16s delay3.53.94.3-2.02.1-2.12.1-2.1-2.1-2.0-1.1
Delay disc. indifference point, 2s delay0.80.82.10.8-0.80.8-0.80.80.80.81.5
Delay disc. indifference point, 24s delay1.51.72.0-1.41.4-1.41.4-1.4-1.4-1.2-0.4
Delay disc. indifference point, 4s delay0.30.30.5-0.70.7-0.50.5-0.5-0.5-0.60.6
Delay disc. indifference point, 8s delay0.60.71.0-1.01.0-0.90.9-0.9-0.9-0.8-0.4
Indifference point function ln k0.00.00.00.2-0.20.2-0.20.20.1-0.0-0.2
Indifference point function log k0.00.00.00.2-0.20.2-0.20.20.1-0.0-0.2
Patch foraging total patch changes 0 sec0.40.81.20.6-0.61.1-1.11.11.00.11.0
Patch foraging total patch changes 12 sec0.00.00.1-0.30.30.1-0.10.20.2-0.30.1
Patch foraging total patch changes 18 sec0.00.00.1-0.10.10.1-0.10.10.10.0-0.3
Patch foraging total patch changes 24 sec0.40.81.50.8-0.81.0-1.01.01.20.60.2
Patch foraging total patch changes 6 sec0.20.30.9-0.50.5-0.30.3-0.3-0.4-0.90.6
Patch foraging time to switch 0 sec3.06.17.3-2.52.5-2.62.6-2.6-2.7-2.1-2.0
Patch foraging water rate 0 sec0.91.92.71.2-1.21.5-1.51.51.61.11.1
Patch foraging water rate 12 sec3.16.58.72.6-2.62.7-2.72.72.92.41.4
Patch foraging water rate 18 sec1.82.83.61.9-1.91.8-1.81.81.91.70.5
Patch foraging water rate 24 sec0.30.50.70.6-0.60.7-0.70.70.80.80.0
Patch foraging water rate 6 sec0.40.51.20.6-0.60.8-0.80.81.10.50.3
Seeking ratio, delayed vs. immediate footshock0.10.10.30.3-0.30.3-0.30.30.50.40.0
Distance traveled before self-admin0.30.31.4-0.50.5-0.40.4-0.4-0.5-0.3-1.2
Distance traveled after self-admin0.10.21.00.1-0.10.1-0.00.0-0.10.4-1.0
Extensor digitorum longus weight2.810.915.63.5-3.43.4-3.43.43.54.01.0
Bone: elastic displacement2.83.24.3-1.91.9-1.91.8-1.8-1.7-2.1-1.0
Bone: elastic work0.30.30.7-0.60.6-0.60.6-0.6-0.5-0.8-0.3
Bone: endosteal estimation1.32.93.41.8-1.81.8-1.81.81.81.51.1
Bone: endosteal perimeter0.91.92.21.5-1.51.5-1.41.41.51.40.7
Epididymis fat weight1.75.96.82.4-2.42.6-2.62.62.61.92.3
Delta time in closed arm before/after self-admin0.00.00.2-0.20.2-0.00.0-0.0-0.10.0-0.5
Delta time in open arm before/after self-admin2.02.02.91.5-1.51.5-1.61.61.71.00.2
Diff in mean of infusions in LGA sessions0.40.51.2-0.60.6-0.60.6-0.6-0.8-1.1-0.7
Delay discount exponential model param0.40.50.70.8-0.80.7-0.70.70.70.7-0.2
Extinction: sum of active levers before priming0.10.10.2-0.00.0-0.40.4-0.4-0.3-0.10.0
Active lever presses in extinction session 60.30.30.60.8-0.80.5-0.40.40.50.4-0.2
Bone: final force1.32.02.31.5-1.51.5-1.51.51.51.40.9
Bone: final moment1.01.61.91.4-1.41.3-1.31.31.41.10.8
Food consumed during 24 hour testing period0.00.00.00.1-0.1-0.10.1-0.1-0.2-0.20.1
Glucose0.20.30.5-0.70.7-0.60.6-0.6-0.5-0.70.4
Heart weight0.10.20.20.4-0.40.4-0.40.40.40.20.3
Delay discount hyperbolic model param0.10.20.30.4-0.50.3-0.30.30.30.4-0.6
Intermittent access intake day 1-15 change0.40.81.2-0.80.8-1.11.1-1.1-0.8-0.3-0.7
Intermittent access intake escalation0.71.42.1-1.11.1-1.41.5-1.5-1.1-0.6-0.9
Intermittent access intake escalation 21.31.52.4-1.11.1-1.51.5-1.5-1.2-0.4-0.9
Intermitt. access day 1 inactive lever presses0.10.40.9-0.50.5-0.60.6-0.6-0.6-0.30.9
Intermitt. access day 15 inactive lever presses0.10.20.5-0.50.4-0.50.5-0.5-0.5-0.7-0.1
Intermitt. access escalation Index2.23.26.21.7-1.71.6-1.61.61.71.82.5
Intermittent access day 1 total infusions0.20.30.50.4-0.40.7-0.70.70.4-0.0-0.5
Intermittent access day 15 total infusions0.30.42.2-0.40.3-0.50.5-0.5-0.4-0.4-1.5
Intermittent access terminal intake (last 3 days)0.30.53.2-0.20.0-0.30.3-0.3-0.3-0.2-1.8
Intermittent access total infusions0.20.30.40.5-0.50.6-0.60.60.50.3-0.4
Intermittent access day 1 locomotion0.10.20.30.3-0.40.5-0.50.50.3-0.0-0.2
Intermittent access day 15 total locomotion0.00.10.20.2-0.30.1-0.10.10.3-0.00.5
Intermittent access total locomotion0.10.10.30.3-0.30.4-0.40.40.3-0.10.5
Intermittent access standard deviation0.61.21.91.1-1.11.0-1.01.01.11.41.2
Left kidney weight3.717.320.74.6-4.54.4-4.44.34.34.41.6
Right kidney weight6.127.833.15.8-5.75.5-5.55.55.35.42.8
Cocaine induced anxiety0.60.94.60.7-0.70.6-0.50.50.60.82.1
Post-drug Anxiety0.50.53.4-0.30.3-0.40.4-0.4-0.4-0.21.8
Baseline Anxiety1.21.41.5-1.21.2-1.21.2-1.2-1.2-1.1-1.2
Tail length0.10.40.90.5-0.50.7-0.70.70.70.21.0
Length with tail0.00.20.30.5-0.40.5-0.50.50.5-0.10.4
Length without tail0.10.20.40.6-0.60.3-0.30.30.40.40.1
Times rat made contact with spout1.31.57.4-0.80.8-0.80.8-0.8-0.9-0.6-2.7
Lifetime Intake0.30.40.60.6-0.60.7-0.70.70.70.30.4
Liver weight, left2.74.55.32.3-2.32.0-2.02.02.02.12.2
Liver weight, right1.52.73.51.7-1.71.6-1.61.61.51.61.9
Locomotor activity0.50.71.10.9-0.90.9-0.90.91.00.30.7
Locomotor testing distance0.00.10.20.0-0.00.2-0.20.20.4-0.50.2
Locomotor testing rearing0.00.10.20.2-0.20.4-0.40.40.3-0.20.0
Locomotion in novel chamber5.16.57.02.5-2.52.6-2.62.62.62.42.5
Locomotion in novel chamber post-restriction0.30.53.40.5-0.50.3-0.30.30.2-0.21.8
Fecal boli incidents, locomotor time 10.20.42.7-0.10.1-0.10.1-0.1-0.20.21.7
Change in fecal boli incidents, locomotor task0.10.10.40.2-0.20.1-0.10.10.1-0.20.6
Time >=10cm from walls, locomotor time 10.91.01.5-1.01.0-1.01.0-1.0-1.0-1.2-0.6
Bouts of movement, locomotor time 10.10.20.8-0.10.1-0.30.3-0.3-0.4-0.10.9
Total resting periods, locomotor time 10.40.50.8-0.60.6-0.80.8-0.8-0.9-0.50.2
Rest time, locomotor task time 13.34.28.9-1.91.9-2.02.0-2.0-1.9-1.5-3.0
Distance moved, locomotor task time 10.91.31.61.2-1.21.3-1.31.31.30.70.7
Vertical activity count, locomotor time 10.00.00.20.1-0.10.2-0.20.20.2-0.1-0.5
Time >=10cm from walls, locomotor time 20.00.00.00.2-0.20.0-0.0-0.00.10.2-0.2
Bouts of movement, locomotor time 20.40.60.80.7-0.70.8-0.80.80.90.70.7
Total resting periods, locomotor time 20.50.81.10.9-0.91.0-1.01.01.00.90.1
Rest time, locomotor task time 21.41.86.3-1.11.1-1.11.1-1.1-1.0-1.0-2.5
Distance moved, locomotor task time 20.10.10.2-0.30.3-0.50.5-0.5-0.4-0.3-0.1
Vertical activity count, locomotor time 20.81.11.4-1.11.1-1.21.2-1.2-1.2-0.9-0.7
Light reinforcement 10.40.91.2-1.11.1-0.90.9-0.9-1.0-1.1-0.9
Light reinforcement 20.30.50.9-0.70.7-0.70.7-0.7-0.7-0.9-0.1
Bone: marrow area1.32.73.21.7-1.71.8-1.81.81.81.51.1
Bone: maximum diameter2.34.35.02.2-2.22.2-2.22.22.21.91.1
Bone: maximum force0.91.61.91.4-1.41.3-1.31.31.31.20.9
Bone: maximum moment0.71.21.51.2-1.21.1-1.11.11.10.90.8
Mean time between licks in bursts0.51.23.61.2-1.20.6-0.60.60.81.01.9
Mean num. licks in bursts2.53.96.61.9-1.91.9-1.91.92.01.72.6
Cd content in liver0.60.61.9-0.80.8-0.60.6-0.6-0.6-1.40.5
Co content in liver1.72.02.6-1.51.5-1.41.3-1.3-1.4-1.6-1.1
Cu content in liver1.41.72.01.4-1.41.4-1.41.41.41.10.9
Fe content in liver0.10.10.2-0.30.3-0.40.4-0.4-0.5-0.2-0.2
K content in liver1.11.11.71.3-1.30.9-0.90.91.01.20.4
Mg content in liver0.70.71.11.1-1.10.8-0.80.80.91.00.3
Mn content in liver1.31.42.21.4-1.41.2-1.11.11.21.5-0.1
Na content in liver1.41.51.91.4-1.41.2-1.21.21.21.40.6
Rb content in liver0.10.10.4-0.10.1-0.20.2-0.2-0.1-0.6-0.1
Se content in liver0.60.71.31.0-1.00.8-0.80.80.71.10.4
Sr content in liver2.21.92.31.4-1.41.4-1.41.41.41.50.9
Zn content in liver1.31.52.01.2-1.21.3-1.31.31.40.81.3
Bone: minimum diameter0.81.41.81.2-1.21.3-1.31.31.30.90.8
Time in familiar zone, hab. session 10.40.40.5-0.60.6-0.70.7-0.7-0.6-0.7-0.0
Time in novel zone, hab. session 10.20.20.30.4-0.40.5-0.50.50.50.30.2
Total zone transitions, hab. session 10.00.10.10.4-0.40.2-0.20.20.10.00.3
Total locomotion distance, hab. session 10.40.50.80.8-0.80.7-0.70.70.70.10.9
Locomotion velocity, hab. session 10.40.60.90.9-0.90.8-0.80.80.80.20.9
Time in familiar zone, hab. session 20.40.40.50.7-0.70.6-0.60.60.70.40.6
Time in novel zone, hab. session 20.00.00.0-0.10.10.1-0.10.1-0.10.1-0.2
Total zone transitions, hab. session 20.10.10.30.5-0.50.3-0.30.20.30.00.4
Total locomotion distance, hab. session 20.00.10.20.2-0.2-0.10.1-0.1-0.0-0.30.5
Locomotion velocity, hab. session 20.00.10.20.2-0.2-0.10.1-0.10.0-0.30.5
Novel to familiar place preference ratio0.40.50.8-0.50.5-0.80.8-0.8-0.7-0.90.1
Novelty place preference0.70.71.1-0.70.7-1.01.0-1.0-0.8-1.0-0.0
Time in novel zone, NPP test0.50.61.0-0.60.6-0.90.9-0.9-0.7-1.00.1
Total zone transitions, NPP test0.00.00.10.2-0.20.2-0.20.20.10.10.1
Total locomotion distance, NPP test0.10.10.2-0.20.2-0.30.3-0.3-0.4-0.40.1
Locomotion velocity, NPP test0.00.00.1-0.10.1-0.20.2-0.2-0.3-0.30.1
Intraocular pressure0.40.50.80.6-0.70.8-0.80.80.60.90.4
Delta distance traveled before/after self-admin0.20.20.30.5-0.50.5-0.50.50.50.50.1
Delta ambulatory time before/after self-admin0.20.20.30.5-0.50.5-0.50.50.40.60.2
Parametrial fat weight6.715.718.04.1-4.14.2-4.24.24.23.82.6
Pavlov. Cond. lever latency1.41.73.0-1.41.4-1.31.3-1.3-1.3-1.7-0.4
Pavlov. Cond. magazine entry latency6.68.510.33.1-3.13.1-3.13.12.93.21.4
Pavlov. Cond. change in total contacts2.52.64.71.7-1.71.6-1.61.61.62.20.6
Pavlov. Cond. index score4.45.67.92.5-2.52.4-2.42.42.32.81.0
Pavlov. Cond. latency score4.25.47.52.5-2.52.4-2.42.42.32.71.0
Pavlov. Cond. lever contacts2.93.55.12.0-2.01.9-1.91.91.92.20.7
Pavlov. Cond. magazine entry number4.05.07.2-2.42.4-2.32.3-2.3-2.1-2.7-1.0
Pavlov. Cond. intertrial magazine entries0.40.40.7-0.60.6-0.60.6-0.6-0.7-0.8-0.6
Pavlov. Cond. lever-magazine prob. diff.4.85.98.02.6-2.62.5-2.52.52.42.81.1
Pavlov. Cond. response bias2.93.55.62.1-2.11.9-1.91.91.82.40.7
Pavlov. Cond. lever latency2.83.84.8-1.91.9-2.12.1-2.1-2.2-1.4-1.8
Pavlov. Cond. magazine entry latency0.10.10.30.3-0.30.3-0.30.30.30.60.3
Pavlov. Cond. change in total contacts0.71.21.61.0-1.01.2-1.21.21.30.51.3
Pavlov. Cond. index score1.11.41.81.2-1.21.3-1.31.31.31.01.0
Pavlov. Cond. latency score0.91.21.61.1-1.11.2-1.21.21.21.00.8
Pavlov. Cond. lever contacts3.54.86.02.1-2.12.4-2.42.42.51.71.9
Pavlov. Cond. magazine entry number0.20.20.20.5-0.50.5-0.50.50.40.4-0.0
Pavlov. Cond. intertrial magazine entries5.68.410.23.2-3.23.0-3.03.02.83.01.7
Pavlov. Cond. lever-magazine prob. diff.0.91.21.61.1-1.11.2-1.21.21.20.90.9
Pavlov. Cond. response bias1.62.22.71.5-1.51.6-1.61.61.71.11.4
Time in closed arm before self-admin0.20.30.50.4-0.40.6-0.60.60.70.30.4
Time in closed arm after self-admin0.40.41.1-0.70.7-0.40.4-0.4-0.5-0.5-1.0
Time in open arm before self-admin0.10.20.3-0.20.2-0.40.4-0.4-0.60.20.6
Time in open arm after self-admin2.02.23.41.8-1.81.4-1.41.41.51.70.1
Bone: periosteal estimation1.94.15.12.0-2.02.2-2.22.22.21.81.2
Bone: periosteal perimeter2.44.14.92.1-2.12.2-2.22.22.21.81.1
Bone: post-yield work3.65.36.12.5-2.52.4-2.42.42.42.01.6
Progressive ratio test 1 active lever presses0.50.60.90.8-0.81.0-1.01.00.90.5-0.2
Progressive ratio test 1 breakpoint0.50.60.80.7-0.70.9-0.90.90.90.5-0.3
Progressive ratio test 1 inactive lever presses0.40.63.70.5-0.40.5-0.50.50.50.11.9
Progressive ratio test 2 active lever presses0.00.00.10.0-0.00.2-0.20.20.2-0.2-0.0
Progressive ratio test 2 breakpoint0.00.00.0-0.00.00.2-0.20.20.2-0.20.0
Progressive ratio test 2 inactive lever presses0.10.10.20.3-0.30.3-0.30.30.4-0.00.3
Incentive Sensitization - Responses0.50.61.1-0.90.9-0.80.8-0.8-0.7-1.00.0
Incentive Sensitization - Breakpoint0.40.51.0-0.80.8-0.70.7-0.7-0.6-1.00.1
Sum of active levers in priming session hrs 5-60.00.00.10.3-0.30.1-0.10.1-0.2-0.10.3
Progressive ratio0.10.10.8-0.00.0-0.10.1-0.10.1-0.4-0.9
Food seeking constrained by brief footshock0.40.51.2-0.50.5-0.70.7-0.7-0.6-0.5-1.1
Seeking ratio, punishment vs. effort0.00.00.20.1-0.10.1-0.10.1-0.10.50.2
Retroperitoneal fat weight6.427.430.75.4-5.45.5-5.55.55.54.93.8
Reaction time number correct0.30.50.80.7-0.70.7-0.70.70.90.9-0.4
Reaction time mean minus median0.41.11.61.0-1.00.9-0.90.91.20.91.3
Reaction time mean minus median AUC0.51.31.91.2-1.21.0-1.01.01.31.01.4
Reaction time num false alarms0.20.30.5-0.60.6-0.60.7-0.7-0.6-0.1-0.3
Reaction time num false alarms AUC0.10.10.1-0.20.2-0.30.4-0.4-0.40.20.1
Reaction time trials correct on left0.30.50.80.7-0.70.7-0.70.70.90.9-0.4
Reaction time trials on left0.30.60.90.7-0.70.8-0.80.80.90.9-0.3
Reaction time mean0.10.20.60.3-0.30.5-0.50.50.40.20.8
Reaction time mean AUC0.10.10.50.2-0.20.3-0.30.30.20.10.7
Median of all reaction times0.00.00.10.0-0.00.2-0.20.20.1-0.10.4
Reaction time omissions0.40.61.80.5-0.50.7-0.80.80.80.11.4
Reaction time false alarm rate0.40.61.0-0.70.7-0.90.9-0.9-1.0-0.30.2
Reaction time premature initiation rate0.20.32.00.2-0.20.1-0.00.00.30.4-1.4
Reaction time premature initiations0.20.42.20.4-0.40.3-0.30.30.50.7-1.5
Std. dev. reaction times0.71.22.21.0-1.01.1-1.11.11.20.81.5
Reaction time trials completed0.30.60.90.7-0.70.8-0.80.80.90.9-0.3
Reaction time trials AUC0.40.81.20.9-0.90.9-0.90.91.11.0-0.3
Run reversals in cocaine runway, females1.61.63.31.2-1.31.3-1.21.21.21.80.7
Run reversals in cocaine runway, males2.02.02.4-1.51.5-1.51.5-1.5-1.4-1.5-0.7
Latency to leave start box in cocaine runway0.00.00.1-0.10.20.0-0.10.10.2-0.2-0.3
Latency to leave start box in cocaine runway, F0.30.30.50.7-0.50.6-0.60.60.50.60.5
Latency to leave start box in cocaine runway, M0.70.71.4-0.90.9-0.70.7-0.6-0.4-0.9-1.2
Std. dev. time between licks in bursts2.73.65.12.0-2.01.8-1.81.81.81.92.2
Total sessions with >9 infusions1.82.13.21.3-1.21.6-1.61.61.50.91.8
Short access day 1 total inactive lever presses0.50.61.9-0.60.7-0.50.6-0.6-0.7-1.01.4
Short access day 10 total inactive lever presses1.43.54.3-1.92.0-1.91.9-1.9-2.1-1.91.0
Short access day 1 total infusions0.20.20.50.2-0.20.5-0.50.50.50.00.7
Short access day 10 total infusions0.20.30.40.4-0.40.6-0.60.60.70.20.3
Short access total infusions0.81.12.10.8-0.81.1-1.11.11.10.51.4
Short access day 1 locomotion0.10.20.4-0.50.5-0.20.2-0.2-0.2-0.6-0.6
Short access day 10 total locomotion1.32.43.21.6-1.61.5-1.51.51.81.41.7
Short access total locomotion1.41.72.21.3-1.31.5-1.51.51.50.91.0
One hour access (0.3 mA shock)0.40.51.40.7-0.80.4-0.40.40.80.5-1.2
Compulsive drug intake0.20.30.40.5-0.60.5-0.50.50.50.3-0.7
One hour access (shock baseline)0.10.10.6-0.10.1-0.40.4-0.4-0.1-0.2-0.8
Social response proportion0.80.91.21.1-1.11.1-1.11.10.90.70.6
Social responses0.30.41.2-0.60.6-0.60.5-0.5-0.7-1.1-0.1
Social time0.40.50.8-0.30.3-0.80.8-0.8-0.8-0.8-0.9
Soleus weight1.54.34.92.2-2.22.2-2.22.22.22.20.9
Bone: stiffness0.40.70.80.9-0.90.9-0.90.90.90.80.5
Tibialis anterior weight4.415.017.34.0-4.04.1-4.04.04.23.92.4
Time to tail flick, vehicle, before self-admin1.01.01.41.2-1.20.9-0.90.91.01.01.1
Time to tail flick, vehicle, after self-admin1.52.02.2-1.31.3-1.41.4-1.4-1.3-1.5-1.5
Time to tail flick, test, before self-admin0.00.00.1-0.00.00.2-0.10.10.1-0.1-0.3
Time to tail flick, test, after self-admin0.20.30.70.5-0.50.3-0.30.30.10.8-0.7
Delta time to tail flick, vehicle, before/after SA0.30.30.6-0.70.7-0.40.3-0.3-0.3-0.8-0.2
Delta time to tail flick, test, before/after SA0.70.71.41.0-1.00.7-0.70.70.41.2-0.3
Tibia length0.10.20.40.6-0.60.4-0.40.40.50.4-0.4
Ambulatory time before self-admin0.91.34.1-0.90.9-0.90.9-0.9-1.1-0.8-2.0
Ambulatory time after self-admin0.40.53.2-0.30.3-0.40.4-0.4-0.60.1-1.8
Bone: tissue strength0.20.20.4-0.30.3-0.60.6-0.6-0.5-0.3-0.0
Total heroin consumption0.70.81.2-0.70.7-1.11.1-1.1-0.9-0.90.1
Bone: trabecular number0.00.00.10.2-0.20.2-0.20.20.20.10.3
Bone: trabecular spacing0.20.20.40.5-0.50.5-0.50.50.40.70.2
Bone: trabecular thickness0.81.01.21.1-1.11.1-1.11.11.10.70.6
Bone: trabecular tissue density0.40.60.7-0.80.8-0.80.8-0.8-0.8-0.7-0.4
Water consumed over 24 hours4.35.815.2-2.12.1-2.22.2-2.2-2.3-1.6-3.9
Number of responses in last shaping day0.00.00.30.0-0.10.1-0.10.1-0.10.1-0.5