Ntng1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	mRNA stability	Ntng1	0.04	0.03	6.3e-03	0.01	0.01	0.02	0.01	6.6e-02	2.3e-02	2.1e-03	3.6e-02
2	Adipose	gene expression	Ntng1	0.8	0.01	0.0e+00	0.58	0.59	0.59	0.59	2.0e-78	1.7e-80	7.9e-81	1.6e-80
3	PL	gene expression	Ntng1	0.1	0.05	7.6e-06	0.06	0.04	0.04	0.05	9.3e-07	2.3e-05	1.1e-05	9.1e-06
4	Liver	gene expression	Ntng1	0.31	0.12	0.0e+00	0.33	0.32	0.33	0.33	4.7e-38	6.6e-37	1.9e-37	1.6e-37
5	NAcc	gene expression	Ntng1	0.04	0.03	1.3e-03	0.02	0.01	0.01	0.01	5.6e-04	4.5e-03	3.9e-02	3.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.4	0.7	1.5	-0.3	-1.0	-1.2	0.6	0.7
Area under the delay curve	0.5	0.6	2.0	0.4	1.4	-0.0	-0.0	-0.8
BMI with tail	2.3	8.0	17.2	-2.0	2.4	-4.2	2.9	-2.2
BMI without tail	0.5	1.4	3.6	-0.2	0.1	-1.9	1.9	-0.3
Body weight	0.3	1.3	6.3	0.3	0.0	-2.5	0.6	0.0
Weight adjusted by age	1.3	2.0	3.9	-2.0	1.2	-0.8	1.7	-1.1
Bone surface	0.9	1.7	5.2	-1.3	-0.8	-2.3	0.9	0.4
Bone volume	0.4	0.7	2.6	-0.8	-0.5	-1.6	0.4	0.2
Breakpoint value in progressive ratio session	0.3	0.3	0.7	0.8	-0.4	0.5	-0.2	0.8
Number of licking bursts	1.6	2.6	5.5	-1.2	2.3	0.1	1.0	-2.2
Context. condit. distance diff. score	0.6	0.8	1.7	-0.7	1.2	0.4	-0.2	-1.3
Locomotion velocity, session 1	1.5	1.6	2.5	0.9	-1.5	-0.8	-1.4	1.6
Locomotion distance, session 1	0.4	0.6	1.0	1.0	-0.8	-0.5	-0.6	0.8
Locomotion velocity, session 2	0.8	0.9	2.4	1.5	-0.7	-1.1	-0.2	0.6
Locomotion distance, session 2	0.4	0.6	0.9	0.1	-0.9	-0.7	-0.8	0.9
Locomotion velocity, session 3	0.7	0.9	3.7	0.4	0.3	-1.9	0.5	-0.3
Locomotion distance, session 3	0.2	0.2	0.4	0.2	0.6	-0.4	-0.3	-0.7
Stereotopy head waving bouts, day 3	0.1	0.1	0.4	0.3	0.3	-0.6	0.0	-0.3
Stereotopy head waving duration, day 3	0.3	0.3	0.9	-0.0	0.9	-0.3	0.1	-0.8
Locomotion velocity, session 7	0.1	0.1	0.2	-0.4	-0.4	-0.2	-0.2	0.3
Locomotion distance, session 7	0.5	0.7	1.6	0.3	-0.1	1.3	-1.3	0.2
Stereotopy head waving bouts, day 7	0.6	0.7	1.0	-1.0	0.8	-0.2	1.0	-0.9
Stereotopy head waving duration, day 7	0.8	0.9	2.3	-1.3	0.6	-0.2	1.5	-0.7
Locomotion velocity, session 8	0.4	0.5	0.9	0.3	-0.7	-0.9	-0.8	0.7
Locomotion distance, session 8	0.5	0.7	3.4	0.1	-0.2	0.1	-1.8	0.2
Degree of sensitization distance	0.7	0.8	2.0	0.3	-0.8	1.4	-0.7	0.8
Degree of sensitization stereotypy	0.8	0.9	2.1	-1.5	0.8	-0.2	0.9	-0.9
Conditioned locomotion	0.7	0.8	2.4	1.6	-0.7	0.2	-0.5	0.9
Cocaine response after cond. corrected	0.6	0.8	1.5	1.2	-0.9	-0.2	-0.3	1.1
Cocaine response after cond. not corrected	0.9	1.1	2.0	1.4	-1.0	0.5	-0.6	1.2
Cocaine response before conditioning	0.8	1.0	3.2	0.5	-0.2	1.8	-1.2	0.2
Saline control response	0.9	1.2	2.3	-0.7	-1.0	1.5	-1.2	0.8
Bone: connectivity density	0.8	1.2	2.2	-0.1	-1.4	-1.5	0.7	1.2
Bone: cortical apparent density	1.0	1.3	5.6	0.1	0.2	2.4	-0.9	-0.3
Bone: cortical area	1.2	1.8	3.2	-1.7	0.3	-1.7	1.8	-0.5
Bone: cortical porosity	1.3	1.4	2.2	-1.1	1.1	-1.5	-1.2	-0.9
Bone: cortical porosity	1.2	1.3	2.5	-1.1	1.0	-1.6	-0.9	-0.9
Bone: cortical thickness	0.5	0.8	2.6	-0.3	-0.6	-0.8	1.6	0.5
Bone: cortical thickness	1.0	1.2	2.2	-0.9	0.6	-1.4	1.5	-0.5
Bone: cortical tissue density	1.0	1.4	6.0	0.2	0.1	2.4	-1.0	-0.2
Condit. Reinf. active minus inactive responses	0.5	0.6	1.3	-0.6	-1.1	-0.8	-0.2	0.7
Condit. Reinf. active-inactive response ratio	0.8	0.9	2.4	0.1	-1.5	-0.8	0.1	1.2
Condit. Reinf. active responses	0.6	0.8	1.5	-1.2	-1.0	-1.0	-0.3	0.5
Condit. Reinf. inactive responses	0.2	0.3	0.8	-0.9	0.1	-0.4	-0.6	-0.3
Incentive salience index mean	1.0	1.3	4.6	-2.2	-0.4	-1.3	-0.0	-0.1
Condit. Reinf. lever presses	2.1	3.0	10.3	-3.2	0.8	-1.5	0.2	-1.2
Condit. Reinf. active minus inactive responses	0.5	0.6	2.1	-1.0	-0.1	-1.4	0.0	-0.1
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.3	0.5	-0.4	-0.6	-0.5	0.4
Condit. Reinf. active responses	1.2	1.7	4.7	-1.9	-0.4	-2.2	0.3	0.1
Condit. Reinf. inactive responses	1.2	1.5	3.7	-1.9	-0.5	-1.9	0.5	0.1
Condit. Reinf. lever presses	0.6	0.9	2.6	-1.6	0.6	0.0	-1.0	-0.6
Condit. Reinf. lever reinforcers received	1.0	1.3	3.2	-1.8	-0.6	-1.8	0.2	0.3
Conditioned reinforcement - actives	0.3	0.5	1.6	-1.3	0.0	-0.4	-0.7	-0.5
Conditioned reinforcement - inactives	0.6	0.9	1.8	0.7	-0.6	-1.3	-1.3	0.3
Conditioned locomotion	0.7	1.0	4.2	0.2	-0.2	0.0	-2.1	-0.7
Patch foraging indifference point 0 sec	0.4	0.8	2.1	-0.0	0.9	1.4	-0.2	-1.0
Patch foraging indifference point AUC	0.1	0.1	0.4	-0.1	-0.1	0.7	-0.3	-0.1
Delay disc. indifference point, 0s delay	5.5	6.0	26.1	5.1	0.8	-1.4	-1.0	-0.5
Delay disc. indifference point, 16s delay	1.3	1.4	4.2	-2.0	1.2	0.4	0.7	-1.0
Delay disc. indifference point, 2s delay	1.4	1.6	4.7	2.2	1.0	-1.3	-0.4	-0.5
Delay disc. indifference point, 24s delay	1.3	1.5	4.3	-2.1	-1.0	0.8	-1.0	0.7
Delay disc. indifference point, 4s delay	1.0	1.0	2.1	1.4	1.4	-0.6	0.5	-0.6
Delay disc. indifference point, 8s delay	0.4	0.5	1.3	0.3	1.1	0.7	-0.5	-0.6
Indifference point function ln k	0.4	0.8	1.9	0.7	0.5	-1.4	1.0	-0.3
Indifference point function log k	0.4	0.8	1.9	0.7	0.5	-1.4	1.0	-0.3
Patch foraging total patch changes 0 sec	0.4	0.8	1.9	0.5	0.9	1.4	-0.3	-0.9
Patch foraging total patch changes 12 sec	0.9	1.2	3.4	1.0	-0.4	1.9	-1.1	0.6
Patch foraging total patch changes 18 sec	0.3	0.5	2.0	0.3	-0.4	1.4	-0.5	0.3
Patch foraging total patch changes 24 sec	0.1	0.2	0.6	-0.2	-0.3	0.8	0.0	-0.2
Patch foraging total patch changes 6 sec	1.1	1.6	4.9	-0.4	1.2	2.2	0.3	-1.3
Patch foraging time to switch 0 sec	0.3	0.6	0.8	-0.9	-0.4	0.8	-0.9	0.6
Patch foraging water rate 0 sec	0.2	0.5	2.1	1.4	0.2	0.3	-0.2	-0.5
Patch foraging water rate 12 sec	1.1	2.3	3.7	1.9	1.9	0.1	0.8	-1.8
Patch foraging water rate 18 sec	1.4	2.1	3.8	-0.6	1.9	0.8	1.5	-1.9
Patch foraging water rate 24 sec	1.3	1.9	8.5	2.9	0.7	0.1	0.1	-0.5
Patch foraging water rate 6 sec	0.7	1.0	4.7	2.2	-0.2	-0.4	-0.1	-0.1
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	0.7	-0.0	-0.1	0.9	0.5	0.5
Distance traveled before self-admin	1.5	2.0	6.4	-2.5	-1.1	-0.7	1.1	0.8
Distance traveled after self-admin	0.7	0.9	3.6	-0.2	-0.6	-0.7	1.9	0.0
Extensor digitorum longus weight	0.2	0.7	1.6	0.4	-1.3	-1.1	-0.1	0.8
Bone: elastic displacement	2.2	2.5	7.3	-0.2	1.6	-0.8	2.7	-1.5
Bone: elastic work	1.9	2.5	8.7	0.1	0.4	-1.8	2.9	-0.5
Bone: endosteal estimation	2.2	4.9	8.9	-3.0	1.6	-2.8	1.4	-1.9
Bone: endosteal perimeter	0.9	1.9	6.9	-2.6	0.4	-1.3	-0.3	-0.7
Epididymis fat weight	1.9	6.5	12.7	-3.5	0.9	-3.6	2.5	-0.7
Delta time in closed arm before/after self-admin	1.3	1.2	3.4	-0.3	-0.6	1.2	-1.9	0.8
Delta time in open arm before/after self-admin	1.2	1.1	2.6	1.6	1.1	-0.9	0.7	-0.8
Diff in mean of infusions in LGA sessions	1.9	2.4	8.5	2.9	-1.0	0.3	-0.5	1.4
Delay discount exponential model param	0.4	0.5	1.9	-0.0	-1.4	0.0	-0.1	0.8
Extinction: sum of active levers before priming	0.3	0.3	0.9	0.7	-0.4	0.9	-0.3	0.2
Active lever presses in extinction session 6	0.6	0.6	2.3	-0.6	0.3	-1.5	0.6	0.1
Bone: final force	0.1	0.2	0.4	-0.6	0.2	-0.5	0.5	-0.4
Bone: final moment	0.1	0.2	0.3	-0.5	0.3	-0.4	0.5	-0.4
Food consumed during 24 hour testing period	0.6	0.9	1.3	0.0	-1.2	-0.9	-0.9	1.2
Glucose	0.7	1.1	5.0	-0.8	-0.2	-2.2	-0.1	0.2
Heart weight	1.2	1.8	5.8	-0.2	0.9	-2.4	1.2	-1.0
Delay discount hyperbolic model param	0.4	0.4	1.5	-0.4	-1.2	0.3	0.0	0.6
Intermittent access intake day 1-15 change	0.0	0.0	0.0	0.1	0.2	0.0	0.2	0.2
Intermittent access intake escalation	0.1	0.1	0.3	0.0	0.6	0.4	0.3	-0.1
Intermittent access intake escalation 2	1.1	1.3	2.3	1.2	1.3	-0.3	1.5	-0.9
Intermitt. access day 1 inactive lever presses	0.4	1.3	2.5	0.8	-1.0	-1.2	-1.1	1.6
Intermitt. access day 15 inactive lever presses	0.4	0.9	3.6	-0.0	-0.8	-1.9	0.1	0.3
Intermitt. access escalation Index	2.6	3.7	8.0	2.8	-2.2	-1.0	-1.2	1.9
Intermittent access day 1 total infusions	0.3	0.5	1.9	-0.4	-0.6	-0.4	-1.4	0.3
Intermittent access day 15 total infusions	0.1	0.2	0.4	-0.5	0.1	-0.5	-0.6	-0.1
Intermittent access terminal intake (last 3 days)	0.5	0.6	1.3	-0.7	0.9	0.1	-0.6	-1.2
Intermittent access total infusions	0.4	0.5	1.1	-1.0	0.3	0.2	-1.0	-0.5
Intermittent access day 1 locomotion	1.1	1.4	3.6	0.6	0.6	-1.2	-1.9	-1.2
Intermittent access day 15 total locomotion	0.8	1.5	4.7	-1.3	0.4	-0.8	-2.2	-0.6
Intermittent access total locomotion	0.5	0.6	1.5	-1.2	0.4	-0.2	-1.0	-0.4
Intermittent access standard deviation	0.8	1.6	4.0	-2.0	1.6	0.5	-0.6	-0.9
Left kidney weight	0.1	0.6	2.8	-0.0	-0.1	-1.7	0.3	0.1
Right kidney weight	0.4	2.0	4.6	2.1	-1.5	-0.9	-0.3	1.5
Cocaine induced anxiety	0.2	0.3	0.8	0.6	0.5	-0.3	0.9	-0.2
Post-drug Anxiety	0.3	0.3	1.0	0.7	-0.3	0.0	1.0	0.1
Baseline Anxiety	0.2	0.3	0.6	0.4	-0.6	0.8	0.4	0.2
Tail length	1.3	5.2	10.2	2.3	-3.2	0.7	-1.8	2.7
Length with tail	1.1	4.7	7.0	2.6	-2.6	0.3	-2.0	2.4
Length without tail	0.3	0.8	2.3	1.3	-0.2	-0.3	-1.5	0.2
Times rat made contact with spout	0.2	0.2	0.7	-0.4	0.2	-0.0	-0.8	-0.3
Lifetime Intake	0.4	0.5	1.1	-0.6	0.7	0.3	-1.0	-0.8
Liver weight, left	0.9	1.5	5.1	-0.8	-0.7	-2.3	1.0	0.6
Liver weight, right	0.6	1.1	4.8	-0.4	0.5	-2.2	-0.1	-0.6
Locomotor activity	0.4	0.6	1.1	1.1	-0.9	-0.6	-0.2	0.8
Locomotor testing distance	0.9	1.5	3.3	1.8	-1.5	-0.6	-0.3	1.3
Locomotor testing rearing	0.5	1.0	2.8	0.2	-1.7	-0.1	-0.2	1.5
Locomotion in novel chamber	0.4	0.6	1.2	-1.0	-0.5	0.1	-1.1	0.5
Locomotion in novel chamber post-restriction	0.3	0.4	1.8	-1.4	-0.1	0.2	0.2	0.5
Fecal boli incidents, locomotor time 1	0.4	0.6	1.3	-0.4	1.2	-0.1	0.6	-1.1
Change in fecal boli incidents, locomotor task	0.7	0.7	1.8	-1.0	0.5	1.3	0.5	-0.2
Time >=10cm from walls, locomotor time 1	0.8	0.9	2.5	-0.6	1.6	0.1	0.6	-1.1
Bouts of movement, locomotor time 1	2.0	2.2	4.0	-2.0	1.0	1.6	1.0	-1.6
Total resting periods, locomotor time 1	2.5	2.7	5.3	-2.3	1.0	1.6	1.5	-1.6
Rest time, locomotor task time 1	6.9	8.6	29.2	-5.4	1.9	0.2	2.2	-2.3
Distance moved, locomotor task time 1	1.5	2.2	5.7	2.4	-1.4	-1.4	-0.6	1.0
Vertical activity count, locomotor time 1	1.8	4.4	10.4	3.2	-2.1	-0.5	-1.6	2.1
Time >=10cm from walls, locomotor time 2	0.4	0.6	1.5	0.8	1.2	-0.2	0.5	-0.8
Bouts of movement, locomotor time 2	0.4	0.6	1.3	0.6	1.1	-0.5	0.6	-0.8
Total resting periods, locomotor time 2	0.5	0.9	2.3	-0.5	1.5	-0.4	0.8	-1.1
Rest time, locomotor task time 2	1.8	2.3	10.0	-3.2	0.5	0.7	0.5	-0.7
Distance moved, locomotor task time 2	1.9	2.2	7.6	2.8	-0.8	-1.4	-0.7	0.6
Vertical activity count, locomotor time 2	0.9	1.3	4.1	2.0	-0.8	-0.9	-0.5	0.7
Light reinforcement 1	0.5	1.3	4.5	0.8	-1.0	0.4	-2.1	0.6
Light reinforcement 2	0.7	1.1	2.6	-0.7	-1.2	-1.6	0.1	0.9
Bone: marrow area	2.4	5.2	9.1	-3.0	1.7	-2.9	1.4	-2.0
Bone: maximum diameter	0.8	1.5	4.5	-2.1	0.2	-1.6	0.7	-0.4
Bone: maximum force	0.5	0.8	2.0	-1.0	0.4	-1.4	0.9	-0.4
Bone: maximum moment	0.4	0.7	1.6	-0.9	0.4	-1.3	0.9	-0.5
Mean time between licks in bursts	0.3	0.7	1.1	1.0	-0.6	-1.1	-1.0	0.6
Mean num. licks in bursts	1.7	2.7	5.2	1.2	-2.3	0.1	-1.6	2.1
Cd content in liver	0.1	0.1	0.2	0.3	0.4	0.1	-0.4	-0.4
Co content in liver	1.4	1.6	3.6	-1.3	0.3	-1.6	1.9	-0.6
Cu content in liver	0.8	0.9	2.7	-1.6	0.7	0.0	0.5	-1.0
Fe content in liver	2.0	2.5	4.5	-2.1	1.5	-0.7	1.3	-1.9
K content in liver	0.6	0.6	1.1	0.6	-1.1	0.8	0.0	0.8
Mg content in liver	1.3	1.3	2.0	1.1	-1.2	1.4	-0.9	1.0
Mn content in liver	6.9	7.6	9.4	2.8	-2.9	2.6	-2.4	3.1
Na content in liver	0.7	0.7	1.3	-0.8	1.1	0.3	0.5	-1.2
Rb content in liver	0.6	0.7	1.5	1.2	-0.3	1.2	0.8	0.0
Se content in liver	0.6	0.8	1.1	1.0	-0.6	1.0	-1.1	0.7
Sr content in liver	0.7	0.6	1.5	-1.2	0.8	-0.6	0.2	-0.8
Zn content in liver	2.4	2.6	4.3	-1.5	1.1	-1.9	2.1	-1.3
Bone: minimum diameter	2.0	3.6	7.8	-2.2	0.8	-2.8	2.0	-1.0
Time in familiar zone, hab. session 1	0.8	0.8	1.5	-0.9	1.2	0.4	-0.5	-1.1
Time in novel zone, hab. session 1	0.8	0.8	1.2	0.7	-1.0	0.6	1.1	1.0
Total zone transitions, hab. session 1	0.3	0.4	1.2	0.0	0.2	1.1	-0.9	-0.2
Total locomotion distance, hab. session 1	0.8	1.2	2.5	-1.6	1.1	0.0	-0.6	-1.4
Locomotion velocity, hab. session 1	0.5	0.8	1.4	-1.2	0.9	-0.1	-0.6	-1.1
Time in familiar zone, hab. session 2	0.6	0.7	1.2	-0.6	1.0	0.5	1.1	-0.8
Time in novel zone, hab. session 2	0.9	0.9	2.2	0.6	-1.5	-0.4	-0.4	1.2
Total zone transitions, hab. session 2	2.2	2.8	4.4	-2.1	1.8	-0.6	1.3	-2.0
Total locomotion distance, hab. session 2	2.1	2.7	5.9	-2.4	1.4	-1.2	1.1	-1.8
Locomotion velocity, hab. session 2	2.1	2.8	6.3	-2.5	1.5	-1.1	0.9	-1.9
Novel to familiar place preference ratio	2.9	3.1	4.9	2.2	-2.0	1.4	-0.3	2.2
Novelty place preference	3.4	3.7	6.3	2.4	-2.2	1.1	-0.3	2.5
Time in novel zone, NPP test	3.5	3.8	6.3	2.4	-2.3	1.2	-0.2	2.5
Total zone transitions, NPP test	1.0	1.5	4.0	-1.5	0.4	-2.0	0.5	-0.7
Total locomotion distance, NPP test	1.5	2.1	5.6	-2.4	1.0	-1.2	-0.3	-1.5
Locomotion velocity, NPP test	1.3	1.8	5.3	-2.3	0.8	-1.2	-0.5	-1.2
Intraocular pressure	1.2	1.8	6.2	-2.5	-0.4	-1.4	0.7	0.3
Delta distance traveled before/after self-admin	2.7	2.9	11.9	3.4	0.4	-0.6	1.4	-0.4
Delta ambulatory time before/after self-admin	2.1	2.6	10.2	3.2	0.7	-0.3	1.2	-0.9
Parametrial fat weight	0.5	1.1	1.8	-0.4	-1.3	-1.3	0.4	1.3
Pavlov. Cond. lever latency	0.9	1.1	3.8	1.9	-0.7	0.5	0.6	0.8
Pavlov. Cond. magazine entry latency	1.3	1.7	3.7	-1.9	1.5	0.1	-0.7	-1.5
Pavlov. Cond. change in total contacts	1.7	1.8	2.7	-1.7	1.3	0.3	-1.5	-1.4
Pavlov. Cond. index score	0.9	1.2	2.9	-1.7	1.1	0.2	-0.7	-1.1
Pavlov. Cond. latency score	1.1	1.3	3.4	-1.9	1.2	0.0	-0.7	-1.2
Pavlov. Cond. lever contacts	0.7	0.9	1.7	-1.3	0.6	-0.8	-1.1	-0.8
Pavlov. Cond. magazine entry number	1.6	2.0	4.3	2.1	-1.7	0.1	0.6	1.7
Pavlov. Cond. intertrial magazine entries	0.9	1.1	1.9	0.9	-1.4	-1.1	0.4	1.1
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.3	3.6	-1.9	1.1	0.0	-0.5	-1.1
Pavlov. Cond. response bias	1.6	2.0	6.1	-2.5	1.2	-0.5	-0.7	-1.3
Pavlov. Cond. lever latency	0.6	0.8	1.3	1.1	-1.0	-0.3	0.8	0.9
Pavlov. Cond. magazine entry latency	0.8	0.9	1.6	-1.3	0.8	1.1	-0.9	-0.5
Pavlov. Cond. change in total contacts	0.2	0.4	0.8	-0.5	-0.7	0.2	-0.7	0.9
Pavlov. Cond. index score	1.0	1.3	2.8	-1.7	1.3	0.5	-0.7	-1.1
Pavlov. Cond. latency score	0.8	1.0	2.4	-1.6	1.1	0.6	-0.7	-0.9
Pavlov. Cond. lever contacts	0.7	0.9	1.9	-1.4	1.1	0.0	-0.6	-1.0
Pavlov. Cond. magazine entry number	1.0	1.3	3.9	2.0	-0.9	-1.0	0.2	0.7
Pavlov. Cond. intertrial magazine entries	0.5	0.7	1.5	0.3	0.7	-1.2	0.8	-0.9
Pavlov. Cond. lever-magazine prob. diff.	0.7	1.0	2.3	-1.5	1.0	0.6	-0.7	-0.8
Pavlov. Cond. response bias	0.8	1.1	2.6	-1.6	1.1	0.3	-0.7	-1.0
Time in closed arm before self-admin	2.4	3.1	9.3	-1.6	1.4	-0.8	3.0	-0.9
Time in closed arm after self-admin	0.6	0.6	1.0	-1.0	0.9	1.0	0.2	-0.4
Time in open arm before self-admin	4.8	5.2	12.6	1.8	-2.5	0.9	-3.6	1.8
Time in open arm after self-admin	1.0	1.1	3.5	1.9	-0.5	-0.4	-1.2	0.4
Bone: periosteal estimation	2.6	5.4	10.5	-3.2	1.1	-3.1	2.0	-1.4
Bone: periosteal perimeter	1.4	2.5	9.2	-3.0	0.4	-1.6	0.3	-0.7
Bone: post-yield work	1.0	1.5	4.3	-2.1	1.3	-0.0	-0.4	-1.2
Progressive ratio test 1 active lever presses	1.0	1.3	4.8	0.1	-1.2	0.2	-2.2	0.4
Progressive ratio test 1 breakpoint	1.0	1.2	5.0	0.1	-1.1	0.1	-2.2	0.3
Progressive ratio test 1 inactive lever presses	1.8	2.6	4.3	1.7	-1.8	-0.9	-2.1	1.4
Progressive ratio test 2 active lever presses	0.5	0.6	2.0	0.5	-0.8	0.5	-1.4	0.1
Progressive ratio test 2 breakpoint	0.4	0.5	1.6	0.4	-0.7	0.5	-1.3	-0.0
Progressive ratio test 2 inactive lever presses	1.7	2.8	5.8	1.2	-2.4	-0.7	-1.8	1.8
Incentive Sensitization - Responses	0.3	0.4	0.9	0.8	-0.7	1.0	-0.2	0.3
Incentive Sensitization - Breakpoint	0.3	0.4	1.2	0.5	-0.7	1.1	-0.1	0.2
Sum of active levers in priming session hrs 5-6	2.2	2.0	9.6	3.1	0.1	-0.4	-0.4	0.4
Progressive ratio	0.3	0.5	1.3	-0.9	-0.2	-0.6	-1.1	-0.0
Food seeking constrained by brief footshock	0.4	0.5	2.1	-1.4	-0.0	0.2	0.2	-0.3
Seeking ratio, punishment vs. effort	0.4	0.6	1.4	0.4	-0.2	1.2	1.0	0.2
Retroperitoneal fat weight	1.6	6.8	18.3	-2.7	1.5	-4.3	1.9	-1.4
Reaction time number correct	0.7	1.4	3.1	0.9	1.5	0.3	-0.9	-1.8
Reaction time mean minus median	0.7	1.6	4.1	-0.4	-1.7	-0.1	-2.0	1.0
Reaction time mean minus median AUC	1.1	2.7	5.4	0.5	-2.3	0.0	-2.3	1.7
Reaction time num false alarms	1.0	1.4	2.2	1.5	-1.4	-0.6	-0.2	1.5
Reaction time num false alarms AUC	0.6	0.9	1.3	0.9	-1.1	-1.1	-0.0	1.1
Reaction time trials correct on left	0.7	1.4	3.1	0.9	1.5	0.3	-0.9	-1.8
Reaction time trials on left	0.7	1.4	3.0	0.9	1.4	0.3	-1.0	-1.7
Reaction time mean	0.4	0.6	1.6	-0.7	-1.3	-0.0	-0.6	0.8
Reaction time mean AUC	0.7	1.1	2.5	-0.7	-1.6	0.1	-0.9	1.2
Median of all reaction times	0.2	0.3	0.8	-0.6	-0.9	0.1	-0.0	0.7
Reaction time omissions	0.6	0.9	2.0	-1.4	-0.8	-0.1	-1.3	0.5
Reaction time false alarm rate	1.2	1.6	3.0	0.6	-1.6	-1.2	0.8	1.7
Reaction time premature initiation rate	0.3	0.4	0.7	-0.5	0.7	-0.8	0.5	-0.5
Reaction time premature initiations	0.5	0.9	2.1	-0.2	1.4	-0.6	0.1	-1.5
Std. dev. reaction times	0.6	1.1	2.6	-0.3	-1.6	-0.8	-1.1	1.0
Reaction time trials completed	0.7	1.4	3.0	0.9	1.4	0.3	-1.0	-1.7
Reaction time trials AUC	0.9	1.6	3.5	0.9	1.6	0.5	-1.0	-1.9
Run reversals in cocaine runway, females	0.5	0.5	0.7	0.7	0.8	0.7	0.6	-0.7
Run reversals in cocaine runway, males	1.2	1.2	1.9	-0.9	-1.4	1.2	0.2	1.4
Latency to leave start box in cocaine runway	2.3	2.6	8.7	1.4	-0.8	1.1	-3.0	0.8
Latency to leave start box in cocaine runway, F	1.8	2.1	5.3	0.3	-1.7	0.9	-2.3	1.3
Latency to leave start box in cocaine runway, M	1.7	1.6	3.8	1.7	0.9	0.8	-2.0	-0.3
Std. dev. time between licks in bursts	0.3	0.4	1.6	-0.1	-0.2	-0.6	-1.3	0.4
Total sessions with >9 infusions	1.1	1.3	2.6	-0.8	1.6	0.3	-0.6	-1.6
Short access day 1 total inactive lever presses	1.5	2.0	7.4	-2.7	-0.1	-1.3	-1.0	-0.3
Short access day 10 total inactive lever presses	1.3	3.2	6.1	1.3	-2.2	0.1	-1.8	2.5
Short access day 1 total infusions	0.8	1.1	3.0	-0.5	1.7	-0.3	-0.5	-1.5
Short access day 10 total infusions	1.2	1.5	3.1	-1.2	1.4	0.0	-1.0	-1.8
Short access total infusions	1.5	1.9	4.7	-0.8	1.9	0.1	-0.8	-2.2
Short access day 1 locomotion	2.1	2.6	5.0	-1.1	2.2	-1.1	-0.7	-2.2
Short access day 10 total locomotion	1.0	1.9	3.4	0.5	1.8	-0.7	-1.6	-1.7
Short access total locomotion	3.3	3.9	8.6	-0.1	2.9	-1.7	-1.0	-2.7
One hour access (0.3 mA shock)	0.9	1.0	1.9	0.4	-1.2	0.9	-1.4	0.8
Compulsive drug intake	0.4	0.5	1.4	0.6	0.1	-1.2	0.8	-0.2
One hour access (shock baseline)	0.4	0.6	1.8	-0.4	-0.5	0.6	-1.4	0.4
Social response proportion	1.5	1.7	4.9	-2.2	0.8	-0.9	1.2	-0.7
Social responses	1.4	1.8	2.8	-1.7	1.4	-0.9	1.2	-1.5
Social time	0.5	0.7	1.7	-1.3	-0.5	1.0	-0.0	0.5
Soleus weight	0.5	1.5	4.1	-1.4	0.5	-2.0	-1.0	-0.6
Bone: stiffness	0.3	0.4	1.4	-0.8	0.2	-0.5	-1.2	-0.0
Tibialis anterior weight	0.1	0.4	0.9	0.2	0.1	-0.9	-0.9	-0.5
Time to tail flick, vehicle, before self-admin	0.6	0.6	3.0	0.2	0.1	0.2	1.7	-0.0
Time to tail flick, vehicle, after self-admin	3.2	4.2	8.1	2.1	-2.8	0.4	-1.4	2.6
Time to tail flick, test, before self-admin	2.5	2.5	5.9	-2.4	1.3	-0.6	1.2	-1.8
Time to tail flick, test, after self-admin	0.2	0.2	0.7	0.8	-0.1	0.6	-0.1	-0.2
Delta time to tail flick, vehicle, before/after SA	1.6	1.5	4.9	0.4	-1.3	0.1	-2.2	0.8
Delta time to tail flick, test, before/after SA	1.6	1.6	5.9	2.4	-0.8	0.7	-0.2	1.0
Tibia length	0.7	1.8	2.8	-1.4	1.5	-1.3	0.8	-1.7
Ambulatory time before self-admin	1.1	1.6	5.2	-2.3	-0.8	-1.0	0.9	0.7
Ambulatory time after self-admin	1.6	1.8	6.3	-0.8	-0.2	-1.4	2.5	-0.3
Bone: tissue strength	0.7	0.7	2.1	0.1	-0.8	1.4	0.7	0.7
Total heroin consumption	0.0	0.0	0.2	-0.1	-0.2	0.0	-0.2	0.4
Bone: trabecular number	0.3	0.4	0.9	0.5	-0.9	-0.6	-0.2	0.8
Bone: trabecular spacing	2.2	2.9	6.7	-1.1	2.6	0.2	0.8	-2.4
Bone: trabecular thickness	0.6	0.8	2.8	-0.1	-0.8	-1.7	0.5	0.5
Bone: trabecular tissue density	1.1	1.6	5.1	0.4	-0.5	1.4	-2.3	0.7
Water consumed over 24 hours	0.2	0.3	0.8	-0.2	0.2	0.8	-0.9	-0.1
Number of responses in last shaping day	1.3	1.4	3.4	-1.8	0.9	0.2	-1.1	-1.2