Hub : Genes

Nt5c3b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc alternative TSS XM_063269434.1 0.02 0.01 8.6e-03 0 0.01 -0 0.01 4.3e-02 5.1e-03 8.9e-01 2.4e-02
2 NAcc mRNA stability Nt5c3b 0.01 0.01 4.2e-03 0 0.01 0 0 8.8e-02 9.8e-03 1.9e-01 7.1e-02
3 IL gene expression Nt5c3b 0.12 0.08 8.9e-03 0.02 0.09 0.05 0.06 9.5e-02 4.1e-03 2.1e-02 1.7e-02
4 OFC gene expression Nt5c3b 0.17 0.1 1.9e-03 0.09 0.12 0.01 0.13 3.9e-03 1.0e-03 1.9e-01 6.2e-04
5 PL intron excision ratio chr10_85874955_85875040 0.03 0.02 9.4e-03 -0 0 -0 -0 6.8e-01 1.2e-01 8.5e-01 6.9e-01
6 Brain mRNA stability Nt5c3b 0.13 0.06 4.9e-15 0.16 0.17 0.17 0.19 3.0e-15 7.1e-16 1.2e-15 4.6e-17
7 BLA gene expression Nt5c3b 0.05 0.03 8.3e-03 0.02 0.03 0.01 0.01 4.6e-02 1.1e-02 1.5e-01 7.9e-02
8 IC gene expression Nt5c3b 0.09 0.06 2.9e-03 0.06 0.06 0.02 0.03 2.3e-03 2.1e-03 5.1e-02 1.5e-02
9 Brain alternative TSS XM_008768084.4 0.04 0.03 1.2e-03 0.04 0.03 0.01 0.03 8.1e-05 5.7e-04 2.3e-02 1.4e-03
10 Brain alternative TSS XM_017597397.3 0.05 0.04 9.3e-04 0.04 0.03 0.01 0.03 6.5e-05 6.4e-04 2.2e-02 1.9e-03
11 Adipose gene expression Nt5c3b 0.02 0.01 4.4e-03 0 0.01 0.01 0.01 1.1e-01 1.3e-02 4.6e-02 5.9e-02
12 Brain gene expression Nt5c3b 0.05 0.02 2.0e-06 0.09 0.07 0.08 0.09 1.8e-08 1.7e-07 1.2e-07 2.1e-08
13 OFC alternative TSS XM_063269434.1 0.34 0.15 9.9e-04 0.07 0.05 -0 0.06 1.0e-02 2.5e-02 4.2e-01 1.8e-02
14 Liver intron excision ratio chr10_85871015_85874909 0.07 0.05 1.9e-03 -0 0.01 0 -0 5.4e-01 4.5e-02 3.0e-01 4.0e-01
15 PL gene expression Nt5c3b 0.03 0.02 3.5e-04 0.01 0.03 0.02 0.02 1.9e-02 4.7e-04 7.0e-03 5.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.30.61.4-1.2-0.91.00.31.1-0.10.70.50.7-0.70.7-0.90.9-0.20.4
Area under the delay curve0.20.42.10.60.6-0.6-0.9-1.50.4-0.50.2-0.10.1-0.50.2-0.2-0.6-0.6
BMI with tail0.41.43.41.61.4-1.0-0.2-0.10.4-1.1-1.9-1.51.5-0.81.3-1.70.8-0.2
BMI without tail1.05.615.42.32.5-2.2-1.6-0.51.8-2.5-3.0-2.32.3-2.32.8-3.9-1.5-2.2
Body weight1.25.310.63.32.8-2.9-2.5-2.62.6-2.6-2.2-1.51.5-2.41.8-2.30.6-1.5
Weight adjusted by age0.92.66.20.61.2-1.4-2.1-0.92.2-1.5-1.0-1.31.3-1.71.3-1.7-2.5-2.2
Bone surface0.20.31.0-0.8-0.50.2-0.90.61.00.20.30.4-0.4-0.0-0.71.0-0.3-0.1
Bone volume0.20.41.3-1.0-0.70.5-0.51.10.60.40.10.6-0.60.3-0.71.0-0.10.3
Breakpoint value in progressive ratio session0.30.53.3-0.6-0.20.30.20.9-0.1-0.1-0.3-0.30.3-0.20.8-1.1-1.8-0.8
Number of licking bursts0.41.33.7-0.9-1.01.41.61.4-1.91.10.40.6-0.61.3-0.80.61.21.3
Context. condit. distance diff. score2.63.27.02.12.0-2.0-1.5-2.61.4-1.8-1.1-1.91.9-1.81.7-0.9-1.6-1.7
Locomotion velocity, session 10.10.10.5-0.4-0.20.0-0.50.70.40.0-0.20.0-0.0-0.0-0.10.5-0.1-0.1
Locomotion distance, session 10.60.81.41.01.0-1.1-1.2-0.71.2-1.0-0.9-0.80.8-1.00.7-0.6-0.3-0.8
Locomotion velocity, session 20.10.10.4-0.4-0.3-0.0-0.0-0.1-0.00.20.50.1-0.10.00.00.6-0.4-0.1
Locomotion distance, session 20.00.00.20.20.0-0.1-0.3-0.20.3-0.00.00.2-0.2-0.0-0.2-0.20.50.1
Locomotion velocity, session 30.60.71.40.90.9-0.9-0.6-1.20.7-0.8-0.5-0.90.9-0.80.8-0.4-1.1-0.9
Locomotion distance, session 31.01.21.90.91.0-1.1-1.4-1.01.4-1.1-0.8-1.01.0-1.20.8-0.6-1.2-1.3
Stereotopy head waving bouts, day 31.21.52.1-0.9-1.11.21.40.4-1.41.31.21.3-1.31.4-1.21.11.31.5
Stereotopy head waving duration, day 30.40.41.2-0.3-0.50.40.4-0.0-0.60.70.60.8-0.80.7-0.70.81.10.9
Locomotion velocity, session 70.10.21.10.50.2-0.5-0.3-0.50.4-0.1-0.00.1-0.1-0.1-0.20.41.10.2
Locomotion distance, session 71.62.05.31.41.3-1.8-2.3-1.72.2-1.5-0.8-1.01.0-1.60.7-0.2-0.7-1.5
Stereotopy head waving bouts, day 71.72.03.2-1.5-1.61.61.81.1-1.51.61.41.3-1.31.6-1.30.80.71.4
Stereotopy head waving duration, day 72.22.74.4-1.6-1.71.82.11.1-1.91.91.71.6-1.61.9-1.41.01.01.7
Locomotion velocity, session 81.51.96.12.31.8-1.7-1.2-2.51.2-1.4-1.0-0.80.8-1.10.6-0.61.0-0.4
Locomotion distance, session 80.81.23.01.31.3-1.3-1.1-1.70.9-1.1-0.7-1.11.1-1.10.9-0.4-0.8-0.9
Degree of sensitization distance0.30.41.10.70.4-0.9-0.9-1.10.8-0.50.1-0.10.1-0.60.10.40.6-0.2
Degree of sensitization stereotypy1.21.32.5-1.4-1.31.41.61.1-1.31.31.11.0-1.01.3-0.90.60.21.0
Conditioned locomotion0.20.20.8-0.4-0.30.50.90.5-0.90.30.20.5-0.50.40.1-0.5-0.20.1
Cocaine response after cond. corrected0.20.30.9-0.5-0.60.60.70.7-0.60.50.20.9-0.90.5-0.4-0.20.30.4
Cocaine response after cond. not corrected0.40.62.1-0.6-0.80.60.40.5-0.50.50.71.4-1.40.6-0.90.20.90.5
Cocaine response before conditioning0.30.40.9-0.1-0.4-0.1-0.7-0.70.50.11.00.8-0.80.0-0.90.90.90.1
Saline control response0.30.41.50.30.2-0.4-1.2-0.91.2-0.50.40.3-0.3-0.5-0.40.20.1-0.5
Bone: connectivity density0.40.71.8-1.3-1.01.10.41.1-0.20.90.70.7-0.70.8-0.81.0-0.50.4
Bone: cortical apparent density2.84.46.3-2.3-2.22.41.51.3-1.62.32.22.4-2.42.3-2.51.81.62.1
Bone: cortical area0.50.91.9-1.2-1.20.5-0.50.30.50.81.41.1-1.10.5-1.31.30.30.4
Bone: cortical porosity1.21.36.4-0.10.5-0.4-0.70.70.9-0.7-1.2-1.31.3-0.91.3-1.2-2.5-1.2
Bone: cortical porosity1.21.34.70.40.8-0.7-0.80.21.0-0.9-1.3-1.41.4-1.01.4-1.2-2.2-1.3
Bone: cortical thickness1.11.94.9-1.4-1.61.10.6-0.1-0.61.42.21.6-1.61.2-1.81.60.81.0
Bone: cortical thickness1.21.55.1-1.9-1.61.00.30.1-0.41.42.31.1-1.11.0-1.21.5-0.90.4
Bone: cortical tissue density2.74.36.1-2.3-2.22.41.51.4-1.72.32.12.4-2.42.3-2.51.71.62.1
Condit. Reinf. active minus inactive responses0.10.10.6-0.5-0.20.30.20.20.00.20.30.0-0.00.20.10.2-0.8-0.2
Condit. Reinf. active-inactive response ratio0.20.21.7-0.5-0.20.30.50.2-0.20.20.3-0.20.20.10.50.1-1.3-0.4
Condit. Reinf. active responses0.10.10.2-0.5-0.40.40.10.10.00.30.40.3-0.30.2-0.20.3-0.50.0
Condit. Reinf. inactive responses0.20.20.6-0.1-0.30.3-0.5-0.30.30.20.30.7-0.70.2-0.80.50.60.3
Incentive salience index mean0.10.10.3-0.5-0.40.50.50.2-0.30.30.50.3-0.30.3-0.20.1-0.40.0
Condit. Reinf. lever presses0.10.20.4-0.0-0.20.40.2-0.3-0.00.10.50.6-0.60.3-0.5-0.40.60.2
Condit. Reinf. active minus inactive responses0.71.02.8-1.7-1.51.00.31.3-0.21.11.20.6-0.60.7-1.01.6-0.50.3
Condit. Reinf. active-inactive response ratio0.10.20.5-0.6-0.50.2-0.20.40.40.10.6-0.10.1-0.0-0.40.7-0.5-0.4
Condit. Reinf. active responses1.11.64.7-2.2-1.81.30.41.9-0.41.41.20.9-0.91.0-1.01.7-0.70.5
Condit. Reinf. inactive responses0.91.43.2-1.8-1.51.30.41.7-0.71.40.81.3-1.31.1-1.00.9-0.01.0
Condit. Reinf. lever presses0.30.43.6-0.5-0.1-0.1-0.50.30.6-0.10.0-0.30.3-0.40.50.2-1.9-0.7
Condit. Reinf. lever reinforcers received1.01.44.2-2.0-1.61.20.41.7-0.41.31.10.7-0.70.9-0.81.6-0.90.4
Conditioned reinforcement - actives0.51.92.71.01.3-1.2-1.3-0.51.4-1.5-1.4-1.61.6-1.41.2-1.5-1.6-1.6
Conditioned reinforcement - inactives0.10.21.60.30.10.2-0.2-0.2-0.1-0.1-0.00.8-0.80.2-0.5-0.11.30.3
Conditioned locomotion2.33.48.90.81.4-1.2-1.50.41.6-1.8-2.1-2.12.1-1.82.0-2.0-3.0-2.3
Patch foraging indifference point 0 sec0.10.21.1-0.7-0.60.0-0.3-0.30.10.31.10.1-0.1-0.0-0.60.3-0.6-0.3
Patch foraging indifference point AUC0.10.30.8-0.9-0.60.60.70.6-0.50.60.60.3-0.30.5-0.30.1-0.40.2
Delay disc. indifference point, 0s delay0.10.10.2-0.4-0.20.2-0.5-0.20.30.20.30.2-0.20.1-0.2-0.2-0.5-0.1
Delay disc. indifference point, 16s delay0.30.42.50.60.5-0.4-0.1-1.6-0.1-0.40.4-0.10.1-0.30.5-0.6-0.9-0.6
Delay disc. indifference point, 2s delay0.20.31.0-1.0-0.70.5-0.40.9-0.00.40.40.2-0.20.2-0.30.4-0.50.0
Delay disc. indifference point, 24s delay0.50.83.50.70.7-1.1-1.4-1.90.9-0.70.2-0.10.1-0.90.4-0.3-0.9-1.1
Delay disc. indifference point, 4s delay0.10.10.4-0.10.1-0.0-0.3-0.70.1-0.10.40.0-0.0-0.1-0.1-0.0-0.6-0.2
Delay disc. indifference point, 8s delay0.30.52.30.80.6-0.8-1.5-1.50.9-0.60.00.1-0.1-0.7-0.00.10.0-0.5
Indifference point function ln k0.20.51.60.0-0.4-0.1-0.5-1.30.20.41.20.7-0.70.2-0.90.91.00.4
Indifference point function log k0.20.51.60.0-0.4-0.1-0.5-1.30.20.41.20.7-0.70.2-0.90.91.00.4
Patch foraging total patch changes 0 sec0.10.20.8-0.5-0.4-0.2-0.4-0.40.30.10.90.0-0.0-0.2-0.40.1-0.6-0.4
Patch foraging total patch changes 12 sec1.21.64.9-2.2-1.71.50.82.0-0.81.21.11.0-1.01.0-1.00.7-0.90.3
Patch foraging total patch changes 18 sec0.10.31.6-0.6-0.3-0.0-0.00.80.1-0.1-0.0-0.90.9-0.30.3-0.4-1.3-0.7
Patch foraging total patch changes 24 sec0.00.11.2-0.5-0.30.2-0.10.00.20.10.40.0-0.0-0.0-0.30.2-1.1-0.4
Patch foraging total patch changes 6 sec0.20.42.3-0.4-0.1-0.3-0.6-0.10.7-0.30.4-0.30.3-0.60.2-0.5-1.5-1.1
Patch foraging time to switch 0 sec0.20.92.90.50.8-0.7-0.5-0.00.5-0.8-1.1-1.21.2-0.91.5-0.3-1.7-1.1
Patch foraging water rate 0 sec0.00.10.20.1-0.1-0.00.0-0.2-0.10.10.10.3-0.30.1-0.4-0.50.50.2
Patch foraging water rate 12 sec0.00.20.4-0.6-0.60.30.10.4-0.10.50.50.5-0.50.4-0.50.00.20.3
Patch foraging water rate 18 sec1.32.95.8-1.0-1.41.30.9-0.4-1.41.62.02.1-2.11.7-2.21.82.42.0
Patch foraging water rate 24 sec0.10.10.30.20.2-0.3-0.10.1-0.1-0.2-0.4-0.50.5-0.30.4-0.3-0.5-0.3
Patch foraging water rate 6 sec1.21.72.4-1.4-1.51.31.10.8-1.41.51.51.6-1.61.4-1.40.80.81.4
Seeking ratio, delayed vs. immediate footshock0.30.41.81.00.9-0.7-0.6-1.30.1-0.5-0.5-0.70.7-0.40.7-0.1-0.4-0.3
Distance traveled before self-admin0.51.12.90.50.8-0.8-0.9-0.41.0-0.8-0.7-1.51.5-0.90.8-1.2-1.7-1.1
Distance traveled after self-admin0.30.61.80.70.7-0.50.9-0.1-0.6-0.4-0.8-1.31.3-0.41.0-0.5-0.6-0.2
Extensor digitorum longus weight5.321.330.25.55.3-5.4-4.7-4.44.5-5.1-4.5-4.44.4-5.04.3-4.3-2.3-4.2
Bone: elastic displacement2.93.66.21.21.7-1.7-2.0-0.52.2-1.8-2.0-2.12.1-2.02.1-1.7-2.5-2.1
Bone: elastic work1.52.05.40.61.1-1.1-1.4-0.31.6-1.2-1.4-1.61.6-1.31.7-1.2-2.3-1.6
Bone: endosteal estimation1.53.78.31.21.6-2.0-2.9-0.42.8-1.9-2.1-1.91.9-2.21.6-1.1-1.9-2.0
Bone: endosteal perimeter0.41.12.40.50.8-1.0-1.60.51.5-1.0-1.4-1.01.0-1.20.8-0.6-1.0-1.0
Epididymis fat weight0.10.31.80.50.3-0.2-0.2-0.60.4-0.30.10.4-0.4-0.1-0.1-1.40.9-0.0
Delta time in closed arm before/after self-admin0.40.32.10.70.40.00.6-0.4-0.4-0.0-0.2-0.30.30.3-0.30.81.40.7
Delta time in open arm before/after self-admin0.10.10.9-0.2-0.20.20.10.3-0.30.10.10.2-0.20.10.2-1.00.0-0.0
Diff in mean of infusions in LGA sessions0.91.64.60.50.9-0.8-0.50.30.6-1.0-1.4-1.61.6-1.11.8-1.6-2.1-1.4
Delay discount exponential model param0.30.42.6-0.6-0.60.70.91.6-0.40.5-0.30.1-0.10.6-0.20.20.60.6
Extinction: sum of active levers before priming2.23.36.51.51.7-2.0-2.2-1.52.5-1.9-1.5-1.31.3-2.01.7-2.2-1.7-2.0
Active lever presses in extinction session 60.60.62.9-0.10.5-0.1-0.60.50.1-0.6-0.9-0.90.9-0.50.9-1.0-1.7-0.9
Bone: final force1.42.24.0-1.6-1.71.10.40.6-0.51.51.91.9-1.91.3-1.92.01.51.3
Bone: final moment1.01.73.4-1.4-1.50.90.10.4-0.11.21.71.7-1.71.0-1.71.81.31.1
Food consumed during 24 hour testing period0.10.20.80.50.2-0.00.6-0.4-0.40.10.00.3-0.30.2-0.00.00.90.6
Glucose0.50.82.20.60.9-0.7-0.30.30.4-0.7-1.5-1.41.4-0.71.3-0.3-1.0-0.6
Heart weight0.30.51.91.30.8-0.8-0.2-1.30.2-0.7-0.2-0.30.3-0.40.10.11.4-0.0
Delay discount hyperbolic model param0.30.42.0-0.6-0.60.60.91.4-0.40.5-0.20.1-0.10.6-0.20.20.60.7
Intermittent access intake day 1-15 change0.63.55.6-1.2-1.42.12.41.9-2.31.70.62.1-2.12.1-1.51.32.22.3
Intermittent access intake escalation0.84.47.5-1.3-1.62.32.41.8-2.41.91.02.1-2.12.4-2.01.72.72.7
Intermittent access intake escalation 21.11.84.2-0.6-0.91.41.61.4-1.51.20.21.1-1.11.5-1.21.22.11.9
Intermitt. access day 1 inactive lever presses0.00.21.20.20.20.41.1-0.1-0.90.1-0.00.4-0.40.40.0-0.60.40.4
Intermitt. access day 15 inactive lever presses0.10.51.6-0.9-0.80.6-0.80.60.20.30.61.3-1.30.3-0.90.40.1-0.0
Intermitt. access escalation Index0.00.10.40.20.0-0.10.2-0.7-0.30.20.40.1-0.10.2-0.00.50.50.5
Intermittent access day 1 total infusions0.10.41.00.40.5-0.6-0.9-0.80.7-0.7-0.1-0.50.5-0.80.3-0.6-0.9-1.0
Intermittent access day 15 total infusions0.40.91.5-0.8-0.81.20.80.5-0.90.80.81.1-1.11.1-1.21.01.01.0
Intermittent access terminal intake (last 3 days)0.30.51.3-0.6-0.50.90.40.4-0.40.60.60.9-0.90.8-1.01.10.60.7
Intermittent access total infusions0.10.10.3-0.2-0.10.30.0-0.2-0.10.10.40.2-0.20.2-0.50.60.00.1
Intermittent access day 1 locomotion0.10.20.7-0.30.00.0-0.10.80.2-0.3-0.3-0.20.2-0.30.3-0.7-0.8-0.6
Intermittent access day 15 total locomotion0.10.22.0-0.4-0.20.50.51.4-0.20.1-0.60.2-0.20.3-0.0-0.2-0.00.2
Intermittent access total locomotion0.40.42.4-0.8-0.50.90.91.5-0.70.4-0.10.4-0.40.5-0.2-0.0-0.40.3
Intermittent access standard deviation0.20.82.1-0.5-0.51.10.91.0-1.00.6-0.01.5-1.50.9-0.70.30.80.9
Left kidney weight0.22.04.7-0.4-1.00.91.9-0.5-1.71.41.61.3-1.31.5-1.20.82.21.9
Right kidney weight0.31.93.7-0.7-1.01.21.80.4-1.91.41.21.4-1.41.6-1.11.01.91.9
Cocaine induced anxiety0.51.26.41.81.4-1.3-1.0-2.50.9-1.1-0.4-0.30.3-1.00.5-0.10.3-0.7
Post-drug Anxiety1.92.16.42.01.8-1.7-1.4-2.51.2-1.6-0.9-0.90.9-1.51.2-1.3-0.5-1.3
Baseline Anxiety0.61.02.8-0.20.3-0.4-0.91.00.7-0.6-0.9-1.21.2-0.81.0-1.6-1.7-1.2
Tail length0.63.36.71.61.6-2.1-2.6-2.32.5-1.9-0.7-0.60.6-2.11.2-2.0-1.7-2.2
Length with tail0.62.99.22.21.8-2.2-2.3-3.02.3-1.8-0.6-0.20.2-1.70.7-1.20.2-1.3
Length without tail0.21.37.01.00.2-0.6-0.5-2.00.40.10.91.0-1.00.1-1.11.32.71.0
Times rat made contact with spout0.20.20.60.40.30.10.00.50.0-0.3-0.8-0.70.7-0.00.1-0.30.70.2
Lifetime Intake0.10.10.3-0.20.00.1-0.5-0.60.4-0.10.50.1-0.1-0.0-0.60.5-0.2-0.3
Liver weight, left0.20.31.1-0.1-0.3-0.3-0.7-0.90.50.21.0-0.10.1-0.0-0.91.00.50.1
Liver weight, right2.23.96.2-1.8-2.01.92.50.7-2.42.12.52.0-2.02.2-1.91.11.72.1
Locomotor activity0.81.23.7-1.5-1.21.21.41.9-1.31.20.40.6-0.61.1-0.50.9-0.30.7
Locomotor testing distance0.51.34.2-1.8-1.31.31.32.1-1.11.20.40.4-0.41.0-0.40.9-1.10.6
Locomotor testing rearing0.20.87.3-1.4-0.60.60.31.3-0.10.50.1-0.40.40.20.40.1-2.7-0.6
Locomotion in novel chamber0.40.61.6-1.3-0.80.6-0.20.10.40.81.10.5-0.50.5-0.61.2-1.20.1
Locomotion in novel chamber post-restriction0.00.10.7-0.10.20.2-0.10.80.3-0.1-0.7-0.30.3-0.00.1-0.2-0.10.1
Fecal boli incidents, locomotor time 10.20.52.9-0.4-0.50.51.01.7-0.80.5-0.5-0.30.30.40.10.40.50.7
Change in fecal boli incidents, locomotor task0.80.82.5-0.5-0.60.91.20.0-1.60.81.01.4-1.40.9-0.30.30.60.8
Time >=10cm from walls, locomotor time 11.01.23.3-0.8-1.00.80.5-0.2-0.41.01.41.8-1.80.9-1.11.51.00.9
Bouts of movement, locomotor time 10.10.20.70.80.6-0.4-0.4-0.70.2-0.4-0.30.0-0.0-0.30.1-0.40.70.0
Total resting periods, locomotor time 10.40.51.21.10.9-0.7-0.6-0.60.5-0.8-0.8-0.40.4-0.60.6-1.00.4-0.3
Rest time, locomotor task time 10.10.20.90.30.3-0.20.00.7-0.3-0.3-0.9-0.50.5-0.30.5-1.0-0.1-0.2
Distance moved, locomotor task time 10.10.31.1-0.10.0-0.2-1.0-1.10.9-0.10.60.5-0.5-0.1-0.20.5-0.5-0.4
Vertical activity count, locomotor time 10.10.71.80.60.8-0.8-1.4-0.91.3-0.8-0.6-0.40.4-0.80.6-0.4-0.9-0.9
Time >=10cm from walls, locomotor time 20.92.53.5-1.9-1.81.81.51.1-1.51.81.71.5-1.51.7-1.61.80.71.5
Bouts of movement, locomotor time 20.30.91.90.91.0-0.9-1.0-1.41.3-1.0-0.4-0.80.8-0.90.7-0.9-1.0-1.2
Total resting periods, locomotor time 20.31.23.51.21.2-1.1-1.3-1.91.4-1.2-0.5-0.80.8-1.10.7-0.8-0.8-1.2
Rest time, locomotor task time 20.40.72.21.51.1-0.7-0.2-0.80.2-0.9-1.10.1-0.1-0.50.6-1.21.0-0.1
Distance moved, locomotor task time 20.20.31.3-0.3-0.1-0.3-1.1-0.61.0-0.10.5-0.30.3-0.3-0.10.5-0.9-0.5
Vertical activity count, locomotor time 20.81.84.60.50.9-1.2-1.7-0.61.7-1.1-0.8-1.81.8-1.31.0-0.7-2.1-1.5
Light reinforcement 10.10.61.6-1.3-1.00.90.30.6-0.30.91.00.9-0.90.7-0.7-0.1-0.30.4
Light reinforcement 20.00.10.5-0.5-0.20.2-0.20.10.10.20.30.1-0.10.1-0.2-0.1-0.7-0.2
Bone: marrow area1.53.68.11.21.6-2.0-2.8-0.42.8-1.9-2.0-1.81.8-2.11.6-1.0-1.9-2.0
Bone: maximum diameter0.40.71.8-1.3-1.10.6-0.50.90.50.71.01.0-1.00.4-1.11.10.10.3
Bone: maximum force0.10.20.9-0.5-0.4-0.1-1.0-0.10.80.20.60.5-0.5-0.0-0.50.70.1-0.1
Bone: maximum moment0.20.31.8-0.3-0.2-0.4-1.3-0.31.2-0.10.30.2-0.2-0.4-0.30.5-0.2-0.4
Mean time between licks in bursts0.10.31.10.80.5-0.00.80.3-0.9-0.2-0.90.1-0.10.00.4-0.31.10.4
Mean num. licks in bursts0.82.14.51.41.5-1.6-1.8-1.32.1-1.6-1.2-1.41.4-1.51.1-1.1-0.9-1.5
Cd content in liver5.96.511.23.03.0-2.5-1.4-1.31.6-2.7-3.4-3.03.0-2.43.1-3.0-1.5-2.0
Co content in liver0.50.51.20.60.5-1.1-0.6-0.80.6-0.5-0.3-0.90.9-0.81.0-0.5-0.7-0.7
Cu content in liver0.50.61.3-0.6-0.90.71.10.2-0.90.81.20.8-0.80.7-0.60.30.80.6
Fe content in liver0.20.31.80.70.4-0.6-0.3-1.30.4-0.40.3-0.10.1-0.40.2-0.30.4-0.3
K content in liver6.26.18.7-2.9-2.92.72.41.9-2.62.82.82.4-2.42.6-2.22.31.02.2
Mg content in liver5.25.78.1-2.8-2.82.62.11.7-2.32.72.82.5-2.52.5-2.32.31.12.1
Mn content in liver12.213.716.9-4.0-4.13.93.52.6-3.54.14.03.8-3.84.0-3.93.62.53.7
Na content in liver0.50.52.6-1.0-0.81.00.21.6-0.10.6-0.10.7-0.70.6-0.60.30.10.6
Rb content in liver2.52.95.4-2.0-2.11.61.30.9-1.41.92.31.8-1.81.6-1.92.11.01.3
Se content in liver5.06.011.0-2.5-2.52.93.32.2-3.22.62.12.1-2.12.8-1.81.91.52.4
Sr content in liver0.10.10.3-0.5-0.40.00.10.2-0.20.30.60.1-0.10.1-0.10.4-0.3-0.1
Zn content in liver0.30.31.4-0.4-0.20.40.70.6-0.60.2-0.2-0.40.40.10.6-0.7-1.2-0.2
Bone: minimum diameter0.40.72.40.30.5-0.8-1.5-0.11.5-0.7-0.7-0.70.7-0.90.4-0.1-1.0-0.8
Time in familiar zone, hab. session 11.01.11.6-0.7-0.81.11.10.5-1.11.00.91.1-1.11.2-1.10.71.21.3
Time in novel zone, hab. session 10.20.20.4-0.10.1-0.3-0.10.60.1-0.3-0.5-0.60.6-0.40.6-0.0-0.6-0.5
Total zone transitions, hab. session 12.23.16.42.42.2-2.1-1.6-2.51.7-1.9-1.4-1.71.7-1.71.5-0.8-0.6-1.5
Total locomotion distance, hab. session 10.30.52.50.90.8-0.8-0.6-1.60.7-0.6-0.1-0.60.6-0.50.40.2-0.4-0.5
Locomotion velocity, hab. session 10.60.93.21.21.1-1.1-0.9-1.81.0-0.8-0.4-0.80.8-0.80.6-0.0-0.6-0.7
Time in familiar zone, hab. session 21.21.43.5-0.9-0.91.51.91.2-1.71.10.61.0-1.01.4-0.8-0.70.81.3
Time in novel zone, hab. session 20.30.32.6-0.2-0.1-0.6-0.7-0.10.6-0.10.2-0.30.3-0.40.21.6-0.4-0.4
Total zone transitions, hab. session 20.81.11.81.31.2-1.3-1.1-1.10.8-1.1-1.0-1.01.0-1.11.1-0.2-0.4-0.9
Total locomotion distance, hab. session 20.10.20.40.70.5-0.6-0.3-0.40.1-0.4-0.6-0.50.5-0.40.40.30.2-0.1
Locomotion velocity, hab. session 20.40.51.11.10.9-0.9-0.5-0.70.3-0.7-0.9-0.90.9-0.70.80.1-0.2-0.4
Novel to familiar place preference ratio0.60.71.40.60.8-0.8-1.1-1.01.1-0.9-0.3-0.70.7-0.90.5-0.4-1.2-1.1
Novelty place preference0.40.51.00.40.5-0.7-0.9-1.01.0-0.70.0-0.50.5-0.70.3-0.1-0.9-0.9
Time in novel zone, NPP test0.10.10.4-0.00.1-0.2-0.5-0.60.5-0.20.4-0.00.0-0.3-0.10.3-0.6-0.5
Total zone transitions, NPP test1.62.43.21.81.7-1.8-1.8-1.31.7-1.7-1.6-1.51.5-1.71.5-0.9-0.7-1.5
Total locomotion distance, NPP test0.30.50.80.80.8-0.9-0.9-0.70.9-0.7-0.7-0.60.6-0.70.50.2-0.1-0.5
Locomotion velocity, NPP test1.41.92.71.61.6-1.6-1.6-1.31.6-1.5-1.4-1.31.3-1.51.3-0.7-0.7-1.3
Intraocular pressure3.76.18.12.42.4-2.6-2.2-1.92.4-2.7-2.1-2.62.6-2.82.6-2.5-2.2-2.9
Delta distance traveled before/after self-admin0.91.04.5-0.1-0.40.72.10.3-1.90.80.40.5-0.51.0-0.11.01.31.3
Delta ambulatory time before/after self-admin0.40.72.80.3-0.10.41.70.3-1.40.5-0.10.3-0.30.70.20.91.41.1
Parametrial fat weight0.10.10.50.60.4-0.3-0.4-0.40.4-0.4-0.30.1-0.1-0.20.0-0.30.7-0.0
Pavlov. Cond. lever latency1.01.32.70.81.0-1.0-0.50.20.5-1.0-1.4-1.61.6-1.01.6-1.0-1.4-1.0
Pavlov. Cond. magazine entry latency3.24.15.6-2.3-2.32.41.71.6-1.62.31.92.2-2.22.2-2.21.91.22.0
Pavlov. Cond. change in total contacts2.42.65.0-1.6-1.71.81.50.4-1.61.72.21.8-1.81.6-2.01.41.01.3
Pavlov. Cond. index score2.12.74.4-1.6-1.81.81.00.8-1.01.71.82.1-2.11.7-2.11.51.41.6
Pavlov. Cond. latency score2.22.84.8-1.5-1.71.70.90.6-1.01.71.82.1-2.11.7-2.21.61.71.7
Pavlov. Cond. lever contacts1.01.22.6-0.8-1.01.10.50.0-0.51.01.31.6-1.61.1-1.60.91.51.0
Pavlov. Cond. magazine entry number3.95.06.62.52.5-2.6-1.6-1.41.6-2.5-2.5-2.62.6-2.42.6-2.1-1.3-2.1
Pavlov. Cond. intertrial magazine entries0.91.12.01.31.3-1.0-0.6-0.60.5-1.1-1.4-1.21.2-1.01.2-1.4-0.6-0.8
Pavlov. Cond. lever-magazine prob. diff.2.43.04.4-1.9-2.02.01.31.1-1.31.81.92.1-2.11.8-2.11.41.31.6
Pavlov. Cond. response bias2.22.84.8-2.0-2.01.91.10.7-1.01.82.22.0-2.01.7-2.01.50.71.3
Pavlov. Cond. lever latency0.20.30.90.80.5-0.4-0.4-0.90.4-0.6-0.10.1-0.1-0.3-0.1-0.81.0-0.2
Pavlov. Cond. magazine entry latency0.00.00.1-0.0-0.0-0.30.00.1-0.20.1-0.1-0.20.2-0.10.30.3-0.20.0
Pavlov. Cond. change in total contacts0.41.03.7-1.4-1.30.80.51.2-0.61.20.90.3-0.30.8-0.81.9-0.20.8
Pavlov. Cond. index score0.20.31.0-0.8-0.50.20.30.9-0.30.50.1-0.30.30.20.11.0-0.70.2
Pavlov. Cond. latency score0.10.20.8-0.7-0.40.10.20.9-0.20.4-0.0-0.40.40.10.20.8-0.80.1
Pavlov. Cond. lever contacts0.20.30.7-0.8-0.50.40.30.9-0.40.50.1-0.10.10.3-0.00.8-0.80.2
Pavlov. Cond. magazine entry number0.40.52.30.90.9-0.4-0.5-0.70.6-0.9-0.7-0.20.2-0.70.5-1.5-0.1-0.7
Pavlov. Cond. intertrial magazine entries0.30.74.10.70.2-0.4-0.4-2.00.5-0.31.20.8-0.8-0.2-0.6-0.21.2-0.2
Pavlov. Cond. lever-magazine prob. diff.0.20.31.4-0.8-0.60.20.30.8-0.30.60.3-0.20.20.3-0.01.2-0.60.3
Pavlov. Cond. response bias0.60.82.0-1.3-1.10.80.71.1-0.91.10.70.3-0.30.8-0.61.4-0.20.8
Time in closed arm before self-admin0.30.51.8-0.8-0.70.81.30.8-1.30.70.50.4-0.40.70.0-0.1-0.50.4
Time in closed arm after self-admin0.60.63.60.10.10.51.90.5-1.70.2-0.3-0.70.70.50.8-0.6-0.30.3
Time in open arm before self-admin0.10.20.60.60.4-0.2-0.1-0.70.2-0.2-0.1-0.00.0-0.0-0.30.70.80.3
Time in open arm after self-admin0.10.10.3-0.0-0.2-0.1-0.6-0.20.4-0.00.40.5-0.5-0.1-0.3-0.10.6-0.0
Bone: periosteal estimation0.30.73.5-0.30.1-0.7-1.90.21.8-0.5-0.3-0.30.3-0.80.10.3-1.1-0.9
Bone: periosteal perimeter0.10.31.4-0.20.0-0.4-0.90.61.2-0.3-0.4-0.30.3-0.50.2-0.0-0.6-0.5
Bone: post-yield work0.40.71.70.80.8-1.1-1.3-1.30.9-0.8-0.2-0.70.7-0.90.5-0.1-0.4-0.7
Progressive ratio test 1 active lever presses0.10.10.3-0.3-0.10.1-0.5-0.10.5-0.10.40.1-0.1-0.1-0.5-0.3-0.4-0.4
Progressive ratio test 1 breakpoint0.10.10.3-0.3-0.10.1-0.5-0.10.5-0.10.40.1-0.1-0.1-0.5-0.3-0.3-0.4
Progressive ratio test 1 inactive lever presses0.00.10.40.10.0-0.1-0.2-0.70.1-0.20.6-0.20.2-0.2-0.4-0.20.1-0.3
Progressive ratio test 2 active lever presses0.10.20.5-0.5-0.40.4-0.60.10.70.20.50.5-0.50.2-0.70.30.0-0.0
Progressive ratio test 2 breakpoint0.10.20.5-0.5-0.40.4-0.60.20.70.20.40.4-0.40.2-0.70.30.00.0
Progressive ratio test 2 inactive lever presses0.00.10.50.10.10.1-0.7-0.20.6-0.20.00.4-0.40.0-0.60.10.60.1
Incentive Sensitization - Responses0.10.21.0-0.3-0.20.1-1.00.20.90.00.00.3-0.3-0.1-0.30.0-0.1-0.1
Incentive Sensitization - Breakpoint0.10.21.1-0.3-0.20.0-1.00.21.00.0-0.10.3-0.3-0.1-0.3-0.0-0.2-0.1
Sum of active levers in priming session hrs 5-60.30.31.7-0.8-0.30.40.30.8-0.30.30.1-0.50.50.2-0.20.4-1.3-0.2
Progressive ratio0.00.10.5-0.3-0.10.1-0.70.10.60.0-0.2-0.10.1-0.10.1-0.1-0.5-0.1
Food seeking constrained by brief footshock0.10.10.2-0.4-0.40.40.10.0-0.20.30.40.4-0.40.3-0.4-0.20.00.2
Seeking ratio, punishment vs. effort0.00.10.2-0.0-0.10.00.4-0.1-0.50.10.40.4-0.40.1-0.40.20.30.1
Retroperitoneal fat weight0.20.73.81.00.9-0.8-0.1-1.10.6-0.8-0.5-0.50.5-0.61.0-2.0-0.3-0.6
Reaction time number correct0.10.20.50.70.5-0.5-0.4-0.70.4-0.3-0.3-0.70.7-0.30.0-0.20.70.1
Reaction time mean minus median0.00.10.7-0.2-0.1-0.2-0.90.30.5-0.2-0.0-0.20.2-0.3-0.10.0-0.2-0.4
Reaction time mean minus median AUC0.00.20.6-0.8-0.60.2-0.60.60.20.30.4-0.10.1-0.0-0.50.7-0.4-0.2
Reaction time num false alarms0.61.13.6-1.1-1.01.11.81.9-1.31.00.20.7-0.71.0-0.40.30.40.9
Reaction time num false alarms AUC0.61.33.4-1.1-1.21.21.81.8-1.41.10.41.0-1.01.1-0.60.50.81.1
Reaction time trials correct on left0.10.20.50.70.5-0.5-0.4-0.70.4-0.3-0.3-0.70.7-0.30.0-0.20.70.1
Reaction time trials on left0.10.20.50.60.4-0.5-0.3-0.60.3-0.2-0.2-0.70.7-0.2-0.0-0.10.70.1
Reaction time mean1.02.35.3-2.3-2.01.70.81.6-1.21.71.91.1-1.11.3-1.61.9-0.20.8
Reaction time mean AUC0.61.54.1-2.0-1.71.40.51.4-0.81.31.60.6-0.61.0-1.21.6-0.70.4
Median of all reaction times2.33.67.6-2.8-2.52.21.41.9-1.62.12.31.4-1.41.8-2.02.2-0.11.2
Reaction time omissions0.50.82.7-1.6-1.30.90.41.1-0.31.01.10.4-0.40.6-0.50.9-0.90.0
Reaction time false alarm rate0.91.23.9-1.2-1.21.21.62.0-1.31.00.31.1-1.11.0-0.50.50.30.8
Reaction time premature initiation rate0.10.20.8-0.20.10.20.10.2-0.0-0.1-0.10.6-0.60.00.5-0.6-0.9-0.3
Reaction time premature initiations0.00.10.70.30.4-0.2-0.1-0.20.2-0.4-0.3-0.00.0-0.20.6-0.8-0.5-0.3
Std. dev. reaction times0.20.62.3-1.4-1.20.90.21.5-0.50.80.70.3-0.30.5-0.70.6-0.20.2
Reaction time trials completed0.10.20.50.60.4-0.5-0.3-0.60.3-0.2-0.2-0.70.7-0.2-0.0-0.10.70.1
Reaction time trials AUC0.00.20.60.60.4-0.4-0.2-0.50.2-0.2-0.2-0.60.6-0.2-0.1-0.10.80.2
Run reversals in cocaine runway, females1.01.15.21.41.2-1.2-0.9-2.31.0-1.10.1-0.70.7-1.00.5-0.4-0.4-1.1
Run reversals in cocaine runway, males0.40.42.00.20.3-0.6-1.4-1.11.1-0.40.3-0.10.1-0.5-0.60.5-0.1-0.5
Latency to leave start box in cocaine runway0.40.51.51.21.0-0.7-0.2-0.70.4-0.9-1.0-0.60.6-0.60.7-0.80.4-0.3
Latency to leave start box in cocaine runway, F1.72.14.22.01.9-1.4-0.5-1.10.7-1.7-1.8-1.71.7-1.31.6-1.7-0.3-1.1
Latency to leave start box in cocaine runway, M0.80.71.4-0.9-0.90.70.10.2-0.10.91.01.2-1.20.8-1.11.10.60.7
Std. dev. time between licks in bursts0.10.20.7-0.10.10.10.20.7-0.4-0.1-0.60.1-0.1-0.10.6-0.5-0.8-0.2
Total sessions with >9 infusions0.30.30.90.20.4-0.3-0.5-0.60.5-0.60.1-0.50.5-0.50.2-0.9-0.9-0.9
Short access day 1 total inactive lever presses0.10.31.10.10.2-0.2-1.0-0.70.9-0.40.30.2-0.2-0.3-0.50.6-0.2-0.5
Short access day 10 total inactive lever presses0.21.01.90.80.9-1.1-1.2-0.91.4-1.1-0.7-0.60.6-1.11.0-1.2-1.1-1.2
Short access day 1 total infusions0.20.31.5-0.4-0.30.2-0.7-0.90.40.01.20.5-0.5-0.0-0.80.6-0.4-0.5
Short access day 10 total infusions0.10.10.50.00.1-0.0-0.7-0.30.6-0.30.20.0-0.0-0.2-0.40.1-0.1-0.4
Short access total infusions0.10.20.6-0.10.1-0.1-0.8-0.70.5-0.30.60.1-0.1-0.3-0.4-0.0-0.5-0.7
Short access day 1 locomotion0.30.42.8-0.6-0.10.1-0.8-0.20.8-0.30.5-0.10.1-0.4-0.1-0.2-1.7-1.1
Short access day 10 total locomotion0.41.58.1-1.7-1.31.51.32.9-1.01.0-0.11.0-1.01.0-0.4-0.2-0.00.7
Short access total locomotion0.10.10.8-0.6-0.30.50.10.90.1-0.0-0.00.2-0.20.1-0.2-0.5-0.5-0.3
One hour access (0.3 mA shock)0.30.42.1-0.10.2-0.4-1.5-0.31.3-0.5-0.1-0.20.2-0.6-0.20.2-0.7-0.7
Compulsive drug intake0.10.10.6-0.4-0.3-0.2-0.5-0.50.40.20.80.1-0.1-0.1-0.10.1-0.5-0.3
One hour access (shock baseline)0.10.20.60.30.5-0.3-0.8-0.30.8-0.6-0.5-0.40.4-0.4-0.00.0-0.4-0.5
Social response proportion1.31.73.11.61.5-1.30.0-1.10.2-1.3-1.2-1.51.5-1.21.8-1.7-1.0-1.2
Social responses0.10.20.50.20.2-0.20.5-0.1-0.2-0.2-0.2-0.70.7-0.20.7-0.6-0.6-0.3
Social time0.20.42.20.30.4-0.5-1.5-0.11.1-0.7-0.40.0-0.0-0.7-0.2-0.30.3-0.7
Soleus weight0.10.41.60.60.6-0.5-0.10.50.2-0.6-1.3-0.50.5-0.50.7-0.90.2-0.1
Bone: stiffness0.61.12.6-0.9-1.10.70.2-0.2-0.40.91.61.4-1.40.8-1.41.31.10.8
Tibialis anterior weight0.93.14.12.02.0-2.0-1.9-1.71.6-1.9-1.7-1.81.8-1.91.7-1.7-1.1-1.6
Time to tail flick, vehicle, before self-admin0.10.20.40.40.4-0.4-0.6-0.20.3-0.3-0.4-0.60.6-0.3-0.4-0.40.50.0
Time to tail flick, vehicle, after self-admin2.34.77.71.51.9-2.1-2.2-0.92.2-2.1-2.0-2.42.4-2.32.3-2.8-2.2-2.4
Time to tail flick, test, before self-admin0.40.51.30.20.4-0.7-0.6-0.10.9-0.6-0.4-0.60.6-0.81.0-0.5-1.1-0.9
Time to tail flick, test, after self-admin0.91.01.4-1.0-1.11.00.91.1-0.61.00.81.2-1.21.0-1.00.61.21.1
Delta time to tail flick, vehicle, before/after SA0.91.01.90.30.6-0.7-1.10.61.2-0.9-1.2-0.70.7-1.01.4-1.3-1.1-1.2
Delta time to tail flick, test, before/after SA0.60.81.6-0.9-1.00.90.60.5-0.61.01.01.0-1.00.9-1.30.70.80.9
Tibia length0.41.17.51.30.5-0.40.0-1.80.0-0.10.40.7-0.70.2-0.80.82.71.0
Ambulatory time before self-admin0.61.93.80.91.2-1.3-1.3-1.01.4-1.2-0.9-1.81.8-1.41.0-1.4-2.0-1.5
Ambulatory time after self-admin0.61.02.61.31.2-1.00.5-0.5-0.1-0.8-1.3-1.61.6-0.81.3-0.5-0.4-0.4
Bone: tissue strength0.50.52.11.30.8-0.6-0.4-1.20.5-0.7-0.30.2-0.2-0.4-0.1-0.41.40.0
Total heroin consumption0.91.14.5-1.6-1.21.31.22.1-1.21.00.30.7-0.70.9-0.40.3-0.60.5
Bone: trabecular number0.91.84.0-2.0-1.61.80.92.0-0.81.40.91.1-1.11.4-1.21.3-0.21.0
Bone: trabecular spacing0.60.92.01.41.2-1.1-0.9-1.00.8-1.1-1.0-0.70.7-1.00.8-1.20.2-0.7
Bone: trabecular thickness0.20.31.5-0.8-0.70.50.41.2-0.20.60.10.3-0.30.5-0.30.60.10.4
Bone: trabecular tissue density0.61.03.3-0.2-0.70.20.0-1.4-0.20.61.81.2-1.20.5-1.31.21.40.5
Water consumed over 24 hours0.71.44.1-0.5-0.81.21.51.1-1.50.90.50.9-0.91.3-1.00.82.01.5
Number of responses in last shaping day0.20.21.90.20.30.10.10.5-0.1-0.4-0.8-0.00.0-0.10.3-1.40.1-0.2