Hub : Genes

Nsf

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Nsf 0.06 0.03 2.3e-04 0.03 0.03 0.03 0.03 1.4e-04 2.4e-04 1.5e-04 1.2e-04
2 LHb gene expression Nsf 0.34 0.13 5.5e-04 0.11 0.14 0.11 0.16 1.2e-03 3.2e-04 1.7e-03 1.1e-04
3 Liver gene expression Nsf 0.07 0.03 1.3e-07 0.06 0.04 0.02 0.06 1.3e-07 5.2e-05 3.7e-03 5.4e-07
4 BLA mRNA stability Nsf 0.21 0.08 3.3e-07 0.09 0.12 0.12 0.13 2.2e-05 8.7e-07 4.1e-07 2.3e-07
5 PL mRNA stability Nsf 0.05 0.03 6.0e-04 0.03 0.03 0.02 0.03 1.9e-04 8.6e-04 4.0e-03 3.5e-04
6 NAcc mRNA stability Nsf 0.04 0.03 1.3e-04 0.02 0.01 0.02 0.02 1.2e-04 2.3e-03 7.9e-04 3.2e-04
7 Brain mRNA stability Nsf 0.14 0.05 4.6e-11 0.06 0.12 0.11 0.11 1.0e-06 2.0e-11 2.2e-10 1.4e-10
8 pVTA mRNA stability Nsf 0.15 0.07 2.5e-08 0.11 0.12 0.12 0.13 4.0e-09 8.8e-10 3.9e-10 2.7e-10
9 NAcc gene expression Nsf 0.32 0.09 0.0e+00 0.29 0.28 0.28 0.28 9.3e-45 1.2e-41 2.2e-43 1.2e-42
10 Liver mRNA stability Nsf 0.04 0.03 5.9e-04 0.01 0.02 0.03 0.02 8.7e-03 3.4e-03 6.3e-04 4.1e-03
11 Adipose mRNA stability Nsf 0.31 0.09 0.0e+00 0.26 0.24 0.24 0.25 2.4e-28 9.2e-27 1.0e-26 1.0e-27
12 Brain gene expression Nsf 0.25 0.11 0.0e+00 0.17 0.21 0.21 0.21 8.1e-16 1.0e-19 2.2e-19 1.9e-19
13 pVTA gene expression Nsf 0.16 0.06 4.9e-09 0.1 0.11 0.11 0.1 2.9e-08 2.8e-09 5.7e-09 1.1e-08
14 Adipose gene expression Nsf 0.39 0.1 0.0e+00 0.05 0.16 0.16 0.15 5.2e-06 6.4e-18 4.2e-17 1.1e-16

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.71.14.91.5-0.50.50.2-0.30.3-0.7-0.92.00.2-2.2-1.3-0.2-1.0
Area under the delay curve0.10.10.30.00.50.00.20.30.20.50.4-0.2-0.1-0.10.30.4-0.1
BMI with tail1.03.68.51.92.91.01.32.41.12.12.4-1.6-0.01.92.71.61.0
BMI without tail1.64.712.32.43.51.92.42.42.32.52.5-0.51.61.62.31.31.7
Body weight2.19.222.34.64.72.13.14.22.23.13.5-1.11.10.43.63.50.3
Weight adjusted by age0.30.51.70.11.20.30.71.00.20.90.8-0.30.2-0.30.91.3-0.5
Bone surface1.73.110.43.21.61.81.91.51.50.90.62.31.2-2.8-0.21.4-0.8
Bone volume1.22.17.22.71.21.41.30.91.10.40.02.40.9-2.7-0.60.7-0.8
Breakpoint value in progressive ratio session0.50.61.5-1.00.40.60.6-0.40.90.8-0.11.01.01.2-0.4-0.61.2
Number of licking bursts0.71.13.30.30.8-0.30.31.1-0.30.71.6-1.8-0.31.01.81.4-0.3
Context. condit. distance diff. score0.20.20.8-0.40.2-0.4-0.70.1-0.7-0.10.3-0.7-0.90.40.50.1-0.0
Locomotion velocity, session 10.30.41.4-0.0-0.00.70.1-0.20.90.1-0.31.20.6-0.2-0.8-0.90.6
Locomotion distance, session 10.10.10.40.0-0.30.50.10.10.6-0.10.10.50.40.1-0.5-0.60.2
Locomotion velocity, session 20.91.13.0-0.9-0.90.0-0.8-1.40.0-0.9-1.41.60.2-0.7-1.7-1.40.0
Locomotion distance, session 20.40.61.6-0.5-0.30.70.0-0.60.90.1-0.40.90.60.6-1.0-1.31.2
Locomotion velocity, session 30.70.71.90.7-0.9-0.9-0.6-0.5-0.8-1.2-1.00.3-1.1-1.4-0.3-0.0-1.2
Locomotion distance, session 30.60.72.10.7-0.6-1.0-0.40.0-1.0-0.7-0.2-0.5-1.3-1.10.60.9-1.4
Stereotopy head waving bouts, day 31.72.04.4-0.3-1.3-1.0-1.7-1.7-1.1-1.7-2.11.1-1.2-1.5-1.7-1.2-0.9
Stereotopy head waving duration, day 30.60.71.8-0.7-0.6-0.5-1.2-1.2-0.6-0.8-1.30.6-0.5-0.3-1.3-1.0-0.2
Locomotion velocity, session 70.80.91.8-0.6-0.8-1.0-1.3-0.9-1.2-1.3-1.1-0.1-1.4-0.4-0.5-0.8-0.7
Locomotion distance, session 70.20.30.6-0.5-0.3-0.5-0.7-0.7-0.6-0.4-0.7-0.0-0.8-0.1-0.2-0.4-0.1
Stereotopy head waving bouts, day 71.11.22.2-0.4-1.1-1.0-1.3-1.2-1.1-1.3-1.50.7-0.8-1.4-1.2-0.4-1.4
Stereotopy head waving duration, day 71.51.83.3-1.4-1.7-1.3-1.8-1.7-1.4-1.6-1.80.3-0.8-0.5-1.4-1.0-1.0
Locomotion velocity, session 80.60.72.60.51.31.00.50.60.90.80.70.10.41.00.2-0.71.6
Locomotion distance, session 80.30.41.3-1.0-0.20.3-0.6-0.50.1-0.1-0.20.40.00.9-0.7-1.11.0
Degree of sensitization distance0.80.82.2-0.21.11.10.70.51.01.10.6-0.11.11.40.2-0.31.5
Degree of sensitization stereotypy0.80.81.5-0.6-1.1-1.0-1.1-0.9-1.0-1.1-1.00.1-0.8-0.8-0.7-0.1-1.2
Conditioned locomotion0.10.10.3-0.5-0.2-0.2-0.5-0.4-0.2-0.3-0.50.0-0.20.5-0.3-0.50.3
Cocaine response after cond. corrected0.91.13.71.50.2-1.1-0.30.3-0.8-0.7-0.2-0.2-1.4-1.90.41.1-1.8
Cocaine response after cond. not corrected1.11.26.41.4-0.2-0.9-0.3-0.1-0.7-0.9-0.70.5-1.3-2.5-0.10.7-1.9
Cocaine response before conditioning0.40.51.9-0.2-0.70.50.1-0.70.4-0.3-0.71.40.6-0.8-1.1-0.80.1
Saline control response1.41.86.9-0.01.21.81.20.81.51.71.20.11.41.70.5-0.52.6
Bone: connectivity density0.71.24.61.5-0.20.90.80.00.8-0.2-0.62.10.9-2.1-1.20.1-0.7
Bone: cortical apparent density4.96.711.9-2.9-3.3-2.5-3.4-3.5-2.3-3.1-3.30.5-2.0-0.3-2.6-2.7-1.2
Bone: cortical area0.91.46.82.60.80.50.70.90.3-0.20.01.4-0.4-2.5-0.20.9-1.3
Bone: cortical porosity6.77.219.04.42.93.13.52.83.02.62.02.51.7-3.00.92.20.3
Bone: cortical porosity5.76.219.44.42.82.53.23.12.52.32.21.51.1-2.51.42.30.1
Bone: cortical thickness3.35.411.30.5-2.6-2.6-2.3-1.6-2.6-3.3-2.30.3-3.1-2.9-1.4-0.4-3.4
Bone: cortical thickness3.13.76.3-0.4-2.2-2.0-2.0-1.8-1.9-2.5-2.50.8-2.0-2.3-1.7-0.6-2.4
Bone: cortical tissue density4.86.511.8-3.0-3.2-2.4-3.3-3.4-2.3-3.0-3.20.5-1.9-0.2-2.6-2.7-1.1
Condit. Reinf. active minus inactive responses1.31.43.00.41.21.71.60.91.71.61.11.11.70.10.20.60.9
Condit. Reinf. active-inactive response ratio0.40.41.1-0.20.50.80.80.40.81.10.60.40.90.10.30.70.3
Condit. Reinf. active responses1.31.74.00.41.21.91.50.52.01.40.81.62.00.3-0.4-0.21.5
Condit. Reinf. inactive responses0.60.72.50.50.50.80.2-0.40.90.0-0.41.60.8-0.3-1.1-1.21.0
Incentive salience index mean1.01.22.90.40.81.71.40.61.71.20.81.51.7-0.3-0.20.30.7
Condit. Reinf. lever presses0.40.52.40.3-0.11.00.6-0.11.00.10.11.61.0-0.5-0.8-0.60.5
Condit. Reinf. active minus inactive responses1.72.26.21.21.22.21.80.72.21.20.32.52.2-1.3-0.80.30.5
Condit. Reinf. active-inactive response ratio1.51.73.81.01.21.71.91.02.01.40.81.52.0-0.9-0.00.90.2
Condit. Reinf. active responses2.43.38.70.91.52.82.00.72.71.60.22.92.9-0.8-1.2-0.21.3
Condit. Reinf. inactive responses1.51.95.8-0.50.51.80.4-0.61.60.5-0.82.41.80.0-1.8-1.81.8
Condit. Reinf. lever presses0.70.93.20.10.41.51.10.01.40.6-0.11.81.6-0.3-0.8-0.50.8
Condit. Reinf. lever reinforcers received1.82.67.90.81.32.41.70.52.31.30.02.82.4-1.0-1.2-0.21.0
Conditioned reinforcement - actives0.40.62.0-0.20.70.80.50.50.51.01.0-0.20.71.40.4-0.21.3
Conditioned reinforcement - inactives0.71.12.31.51.31.51.11.31.31.11.30.50.6-0.30.30.40.5
Conditioned locomotion1.41.93.61.31.81.61.61.91.11.81.9-0.10.90.21.11.30.7
Patch foraging indifference point 0 sec0.81.43.90.30.81.70.1-0.51.20.2-0.82.01.0-0.5-1.8-1.71.5
Patch foraging indifference point AUC0.50.81.90.51.40.70.90.80.61.11.2-0.50.81.00.90.80.6
Delay disc. indifference point, 0s delay0.30.31.2-1.1-0.40.3-0.3-0.60.40.3-0.10.50.30.7-0.6-0.60.7
Delay disc. indifference point, 16s delay0.60.61.70.91.1-0.50.30.9-0.20.50.7-1.0-0.5-0.61.21.3-0.7
Delay disc. indifference point, 2s delay0.60.72.40.20.21.20.90.11.30.60.31.61.4-0.6-0.9-0.20.3
Delay disc. indifference point, 24s delay0.60.61.50.21.20.50.71.00.51.11.1-0.60.50.31.00.80.2
Delay disc. indifference point, 4s delay0.10.10.2-0.30.5-0.1-0.1-0.00.10.30.10.3-0.4-0.4-0.10.2-0.2
Delay disc. indifference point, 8s delay0.30.30.5-0.6-0.7-0.6-0.7-0.7-0.5-0.6-0.7-0.1-0.6-0.4-0.4-0.4-0.4
Indifference point function ln k0.50.83.70.6-0.40.1-0.1-0.50.2-0.8-1.21.60.1-1.9-1.2-0.3-0.9
Indifference point function log k0.50.83.70.6-0.40.1-0.1-0.50.2-0.8-1.21.60.1-1.9-1.2-0.3-0.9
Patch foraging total patch changes 0 sec0.81.44.00.71.11.80.3-0.21.40.4-0.62.01.0-0.7-1.7-1.51.4
Patch foraging total patch changes 12 sec1.62.17.3-0.20.72.10.6-0.31.81.0-0.21.61.80.9-1.5-1.72.7
Patch foraging total patch changes 18 sec0.30.51.80.71.31.10.50.80.60.90.80.10.3-0.30.10.20.7
Patch foraging total patch changes 24 sec0.61.13.40.51.21.50.1-0.10.90.3-0.61.80.7-0.9-1.5-1.21.0
Patch foraging total patch changes 6 sec0.20.41.20.51.11.10.40.20.60.40.20.50.6-0.2-0.5-0.40.6
Patch foraging time to switch 0 sec0.00.10.3-0.3-0.6-0.20.10.1-0.10.10.3-0.5-0.10.50.50.10.3
Patch foraging water rate 0 sec0.20.31.90.81.40.60.10.40.50.20.10.80.1-0.7-0.40.0-0.2
Patch foraging water rate 12 sec1.02.08.80.60.1-1.4-1.00.5-1.8-1.1-0.3-1.0-1.9-2.10.31.4-3.0
Patch foraging water rate 18 sec1.11.74.3-0.3-0.9-0.8-1.6-1.4-1.2-1.8-2.10.9-0.9-1.5-1.8-1.3-1.2
Patch foraging water rate 24 sec1.21.63.0-0.7-1.3-1.2-1.5-1.4-1.3-1.7-1.70.3-1.3-1.4-1.3-1.0-1.2
Patch foraging water rate 6 sec0.40.52.80.80.40.50.30.40.4-0.2-0.31.20.1-1.7-0.70.3-0.9
Seeking ratio, delayed vs. immediate footshock2.42.96.71.31.10.81.72.20.81.92.6-1.80.91.82.62.00.9
Distance traveled before self-admin0.10.20.9-0.50.40.50.3-0.20.60.4-0.21.00.2-0.1-0.4-0.20.0
Distance traveled after self-admin0.20.21.6-0.5-0.2-0.20.0-0.40.50.1-0.00.10.01.30.1-0.50.6
Extensor digitorum longus weight1.45.325.9-1.7-0.1-1.7-0.51.1-1.70.82.0-5.1-1.63.93.61.70.4
Bone: elastic displacement0.81.02.90.4-1.7-0.9-0.5-0.4-0.9-1.2-0.70.3-1.1-1.6-0.40.3-1.7
Bone: elastic work0.50.63.11.4-0.60.40.50.30.4-0.4-0.21.2-0.2-1.8-0.40.3-0.8
Bone: endosteal estimation4.59.919.33.44.43.84.13.43.63.93.31.63.3-0.61.82.51.7
Bone: endosteal perimeter6.814.630.44.35.54.34.94.54.14.74.21.23.5-0.42.73.21.9
Epididymis fat weight0.20.52.00.61.20.20.70.40.70.80.4-0.20.91.40.80.40.6
Delta time in closed arm before/after self-admin1.41.34.60.7-1.2-1.3-1.2-0.1-1.6-1.6-0.4-0.9-2.2-0.90.2-0.2-1.3
Delta time in open arm before/after self-admin2.42.410.5-2.00.61.00.5-1.11.01.2-0.11.02.03.2-0.7-1.42.5
Diff in mean of infusions in LGA sessions0.50.62.0-0.80.30.70.5-0.40.60.7-0.10.91.01.4-0.3-0.61.2
Delay discount exponential model param0.10.20.5-0.1-0.7-0.1-0.3-0.4-0.4-0.7-0.60.2-0.1-0.1-0.5-0.4-0.1
Extinction: sum of active levers before priming0.40.42.6-0.7-0.40.0-0.0-0.20.10.10.3-0.10.31.6-0.0-0.91.2
Active lever presses in extinction session 62.62.64.81.01.91.62.21.52.02.21.80.41.91.51.21.01.4
Bone: final force0.71.15.11.5-0.10.0-0.3-0.4-0.2-0.9-0.91.7-0.8-2.3-1.1-0.3-1.1
Bone: final moment0.91.46.21.5-0.3-0.0-0.4-0.5-0.2-1.0-1.12.0-0.8-2.5-1.3-0.4-1.2
Food consumed during 24 hour testing period1.21.75.60.92.41.11.11.71.21.61.7-0.41.00.81.30.80.9
Glucose0.71.13.4-0.6-0.7-1.8-1.2-0.4-1.6-1.1-0.5-1.4-1.60.10.50.2-1.2
Heart weight1.42.25.32.00.9-0.40.52.2-0.40.31.8-1.9-1.2-0.32.32.3-1.4
Delay discount hyperbolic model param0.20.20.6-0.1-0.7-0.4-0.4-0.4-0.6-0.8-0.7-0.1-0.3-0.1-0.3-0.3-0.3
Intermittent access intake day 1-15 change0.20.51.80.7-0.3-0.10.21.0-0.6-0.01.1-1.4-0.6-0.11.00.50.1
Intermittent access intake escalation0.20.41.20.9-0.10.20.41.1-0.20.11.1-1.0-0.6-0.20.90.30.3
Intermittent access intake escalation 20.30.41.01.00.30.30.61.00.10.31.0-0.7-0.2-0.00.80.20.6
Intermitt. access day 1 inactive lever presses0.72.86.02.41.31.92.41.72.11.71.70.52.10.11.21.30.9
Intermitt. access day 15 inactive lever presses1.32.65.91.31.92.42.11.22.11.70.91.52.4-1.0-0.11.00.5
Intermitt. access escalation Index0.40.51.6-0.1-0.2-1.1-0.10.1-0.8-0.00.3-1.2-0.80.51.20.9-0.7
Intermittent access day 1 total infusions0.20.30.8-0.00.70.90.50.60.50.90.70.10.50.50.20.40.4
Intermittent access day 15 total infusions1.31.95.21.11.11.51.52.00.91.62.3-0.70.60.91.40.81.5
Intermittent access terminal intake (last 3 days)1.92.55.51.01.82.01.82.11.32.22.3-0.41.20.81.31.01.6
Intermittent access total infusions1.61.94.21.01.51.31.51.61.01.82.1-0.71.11.41.51.01.4
Intermittent access day 1 locomotion2.02.55.01.82.11.71.82.21.41.92.2-0.31.00.21.41.60.6
Intermittent access day 15 total locomotion1.42.56.31.41.91.81.52.21.31.92.5-0.80.91.11.40.91.5
Intermittent access total locomotion3.33.97.52.12.32.32.42.62.02.42.7-0.21.60.61.61.51.5
Intermittent access standard deviation0.51.02.70.40.21.41.00.91.30.91.30.21.21.20.1-0.51.7
Left kidney weight0.20.93.21.4-0.3-0.6-0.50.3-0.7-0.9-0.50.0-1.4-1.70.10.8-1.8
Right kidney weight0.31.44.32.10.0-0.9-0.00.9-0.8-0.60.2-0.7-1.3-1.51.11.7-2.0
Cocaine induced anxiety0.70.92.60.5-1.3-1.0-0.80.0-1.1-1.2-0.3-0.7-1.6-1.2-0.00.2-1.4
Post-drug Anxiety0.40.41.71.3-0.4-0.30.20.8-0.1-0.30.6-0.5-0.7-0.80.50.8-0.9
Baseline Anxiety1.61.93.70.81.71.31.81.21.71.91.40.21.81.01.11.11.0
Tail length0.62.25.02.02.21.71.80.91.81.10.42.02.1-1.2-0.20.50.3
Length with tail0.73.210.63.32.61.32.22.41.31.41.60.11.2-0.71.62.1-0.3
Length without tail0.62.06.02.21.0-0.20.32.1-0.60.41.2-1.6-1.2-0.52.02.4-1.5
Times rat made contact with spout0.10.10.40.50.70.10.00.4-0.10.10.5-0.2-0.4-0.30.40.10.0
Lifetime Intake1.51.83.51.01.61.41.51.61.21.81.9-0.41.11.01.21.01.2
Liver weight, left1.11.85.92.41.81.51.71.51.31.20.71.00.9-1.20.61.20.1
Liver weight, right1.12.06.10.8-1.3-1.6-1.2-0.4-1.7-1.8-1.2-0.1-1.7-2.1-0.30.4-2.5
Locomotor activity1.21.95.00.70.92.01.70.81.91.60.71.12.20.8-0.0-0.22.1
Locomotor testing distance1.62.86.80.51.12.61.90.92.51.90.91.72.50.7-0.3-0.42.5
Locomotor testing rearing1.73.311.4-0.30.82.91.60.82.72.21.01.42.11.7-0.2-0.83.4
Locomotion in novel chamber1.11.43.30.71.71.51.11.51.51.81.00.50.7-1.00.51.30.2
Locomotion in novel chamber post-restriction0.20.31.21.11.10.50.50.30.60.4-0.10.40.7-0.70.10.10.3
Fecal boli incidents, locomotor time 10.10.10.3-0.1-0.2-0.6-0.4-0.3-0.6-0.5-0.2-0.5-0.5-0.10.1-0.3-0.1
Change in fecal boli incidents, locomotor task0.10.10.30.40.50.10.20.10.30.30.10.2-0.2-0.1-0.00.2-0.1
Time >=10cm from walls, locomotor time 10.90.92.5-0.6-0.8-1.4-0.9-0.4-1.3-0.8-0.7-0.7-1.4-0.90.10.6-1.6
Bouts of movement, locomotor time 10.60.71.7-0.5-0.4-1.3-1.0-0.4-1.2-0.9-0.0-1.1-0.8-0.10.20.3-1.3
Total resting periods, locomotor time 10.80.82.7-0.2-0.2-1.4-1.0-0.2-1.3-0.9-0.0-1.3-0.9-0.50.40.7-1.7
Rest time, locomotor task time 10.50.71.3-0.5-1.2-1.0-0.9-1.1-0.9-1.1-1.1-0.2-0.4-0.7-0.5-0.0-1.0
Distance moved, locomotor task time 10.81.23.00.91.30.91.21.70.81.41.6-0.30.40.71.21.10.5
Vertical activity count, locomotor time 10.30.61.40.90.90.50.91.20.80.91.10.20.2-0.20.91.0-0.1
Time >=10cm from walls, locomotor time 20.30.41.60.60.40.70.41.00.40.50.40.3-0.2-1.20.20.8-0.5
Bouts of movement, locomotor time 20.30.52.00.20.1-0.8-0.3-0.8-0.7-0.9-1.00.1-0.3-1.4-0.40.0-1.2
Total resting periods, locomotor time 20.50.92.30.1-0.3-1.2-0.7-1.0-1.1-1.3-1.2-0.3-0.8-1.5-0.40.1-1.5
Rest time, locomotor task time 20.60.72.40.1-0.7-1.6-0.8-0.7-1.2-0.9-0.4-1.3-1.2-0.00.50.3-0.8
Distance moved, locomotor task time 20.20.20.80.00.30.80.50.90.40.60.60.40.30.30.30.30.3
Vertical activity count, locomotor time 20.30.41.80.00.10.90.50.31.00.40.21.30.8-0.4-0.4-0.10.3
Light reinforcement 10.30.82.30.4-0.21.10.2-0.50.8-0.1-0.91.51.3-0.6-1.4-0.90.9
Light reinforcement 20.60.94.20.4-0.40.30.1-0.90.5-0.5-1.02.00.9-1.2-1.6-0.90.0
Bone: marrow area4.49.718.73.44.33.74.13.43.53.93.31.63.2-0.61.82.51.6
Bone: maximum diameter1.63.07.82.82.32.22.01.81.91.71.31.81.1-1.70.41.20.3
Bone: maximum force0.71.26.72.60.90.70.91.00.60.10.51.2-0.2-1.90.00.7-0.8
Bone: maximum moment0.71.26.32.50.70.60.70.70.5-0.10.21.5-0.3-2.2-0.20.6-1.0
Mean time between licks in bursts1.02.47.31.41.4-0.70.31.7-1.00.51.9-2.7-1.10.52.52.2-1.0
Mean num. licks in bursts0.40.61.80.1-0.30.2-0.3-0.70.2-0.6-1.11.40.0-1.0-1.2-1.20.2
Cd content in liver1.71.97.2-2.7-1.4-1.2-1.8-1.6-1.1-0.8-0.7-1.0-1.01.9-0.6-1.40.5
Co content in liver0.50.62.2-1.5-0.70.20.5-0.00.20.90.5-0.70.91.50.50.40.7
Cu content in liver0.30.31.00.10.70.60.70.50.60.80.50.11.00.10.30.9-0.2
Fe content in liver1.01.23.1-1.4-1.0-0.7-1.8-1.3-0.9-1.1-1.30.7-0.8-0.3-1.3-1.1-0.6
K content in liver0.60.61.5-1.0-0.7-0.2-0.5-1.1-0.3-0.6-1.20.90.3-0.6-1.0-0.3-0.7
Mg content in liver3.03.18.6-2.9-2.2-1.4-2.0-2.6-1.3-1.7-2.30.6-0.20.0-2.0-1.5-0.8
Mn content in liver3.43.89.2-1.4-2.3-0.7-1.8-2.5-0.8-2.3-2.72.2-0.2-1.4-3.0-2.3-0.9
Na content in liver0.70.72.1-1.00.11.00.4-0.51.00.6-0.21.21.50.5-0.8-0.71.1
Rb content in liver1.51.85.4-2.3-1.9-0.7-1.4-1.9-0.7-1.0-1.80.50.20.4-1.6-1.40.1
Se content in liver1.11.32.4-1.5-1.3-1.4-1.5-0.8-1.6-0.9-0.4-1.5-1.31.00.3-0.1-0.7
Sr content in liver1.11.03.60.70.6-0.70.20.8-0.80.10.4-0.9-0.8-1.11.21.9-1.8
Zn content in liver0.40.40.9-0.7-0.8-0.9-0.8-0.8-0.7-0.6-0.6-0.3-0.7-0.3-0.4-0.1-0.8
Bone: minimum diameter5.610.220.84.64.63.54.13.83.33.53.11.52.7-1.31.92.90.9
Time in familiar zone, hab. session 10.90.84.5-0.70.70.40.10.30.30.81.0-1.10.02.10.7-0.51.5
Time in novel zone, hab. session 10.90.94.50.6-0.7-0.6-0.3-0.3-0.5-0.8-0.90.9-0.6-2.1-0.60.7-1.8
Total zone transitions, hab. session 10.30.52.1-0.00.1-0.6-0.30.6-0.40.00.8-1.4-0.80.91.10.5-0.2
Total locomotion distance, hab. session 10.30.41.61.30.30.60.70.80.70.40.50.70.4-0.80.10.6-0.3
Locomotion velocity, hab. session 10.40.61.81.30.61.01.01.01.00.70.70.70.8-0.50.20.60.2
Time in familiar zone, hab. session 20.80.94.3-0.40.70.60.30.40.50.81.0-1.00.32.10.7-0.51.7
Time in novel zone, hab. session 21.91.98.40.6-1.1-0.9-0.7-0.8-0.8-1.4-1.51.5-0.8-2.9-1.20.4-2.4
Total zone transitions, hab. session 20.40.52.3-1.4-0.2-0.6-0.7-0.2-0.40.00.5-1.2-0.41.50.5-0.20.3
Total locomotion distance, hab. session 20.10.20.7-0.8-0.1-0.4-0.6-0.3-0.2-0.00.1-0.5-0.10.90.0-0.10.1
Locomotion velocity, hab. session 20.20.20.9-0.8-0.1-0.4-0.6-0.2-0.3-0.00.1-0.7-0.21.00.1-0.20.1
Novel to familiar place preference ratio0.40.41.21.11.10.70.70.80.60.50.50.50.4-0.70.10.5-0.0
Novelty place preference0.30.30.91.00.90.50.50.60.40.30.20.60.2-0.9-0.10.4-0.2
Time in novel zone, NPP test0.30.31.30.90.70.40.20.40.30.1-0.10.8-0.0-1.1-0.30.3-0.4
Total zone transitions, NPP test0.30.51.4-1.2-0.7-0.5-1.2-0.8-0.6-0.6-0.5-0.3-0.50.6-0.5-0.80.0
Total locomotion distance, NPP test0.10.20.70.2-0.20.1-0.4-0.30.2-0.3-0.40.9-0.0-0.7-0.8-0.2-0.4
Locomotion velocity, NPP test0.00.00.10.10.10.1-0.00.10.20.10.10.20.3-0.0-0.20.1-0.2
Intraocular pressure0.70.94.10.32.00.30.70.90.51.31.2-0.90.51.01.10.90.2
Delta distance traveled before/after self-admin0.30.32.2-0.2-0.6-0.5-0.3-0.5-0.0-0.40.1-0.40.01.50.2-0.60.6
Delta ambulatory time before/after self-admin0.30.42.70.5-0.3-0.40.1-0.10.2-0.30.5-0.60.11.60.5-0.50.7
Parametrial fat weight0.20.52.50.60.20.60.0-0.40.6-0.3-0.71.6-0.1-1.1-1.1-0.7-0.2
Pavlov. Cond. lever latency1.82.35.0-2.2-1.3-2.0-2.0-1.7-1.9-1.3-1.4-1.4-1.50.9-0.4-1.0-0.4
Pavlov. Cond. magazine entry latency2.02.510.31.30.82.31.50.22.20.7-0.03.21.9-1.2-1.6-1.01.2
Pavlov. Cond. change in total contacts1.81.94.80.91.12.21.70.72.11.30.82.22.0-0.5-0.6-0.11.0
Pavlov. Cond. index score1.92.46.51.81.12.41.91.02.21.10.72.61.9-1.1-0.8-0.11.0
Pavlov. Cond. latency score1.72.25.31.81.12.31.91.12.11.20.82.11.8-0.9-0.40.11.0
Pavlov. Cond. lever contacts1.92.34.81.91.32.22.11.62.01.41.41.61.7-0.80.20.70.7
Pavlov. Cond. magazine entry number2.22.812.4-0.6-0.3-2.2-1.10.6-2.1-0.40.7-3.5-2.00.92.21.7-1.5
Pavlov. Cond. intertrial magazine entries1.21.43.1-0.01.21.31.01.11.31.51.5-0.61.21.81.00.31.6
Pavlov. Cond. lever-magazine prob. diff.2.12.77.51.91.12.52.01.02.31.10.72.72.0-1.4-0.80.10.7
Pavlov. Cond. response bias2.53.113.41.70.82.41.70.32.30.7-0.13.72.1-1.8-1.7-0.70.7
Pavlov. Cond. lever latency0.10.20.70.0-0.0-0.5-0.40.1-0.4-0.10.3-0.8-0.80.30.50.2-0.1
Pavlov. Cond. magazine entry latency0.30.41.1-0.7-0.7-0.9-0.6-0.5-1.1-0.6-0.4-0.8-0.80.30.30.1-0.5
Pavlov. Cond. change in total contacts0.71.24.2-1.10.51.31.1-0.11.31.30.20.82.01.2-0.2-0.31.6
Pavlov. Cond. index score0.00.10.3-0.2-0.00.30.40.00.20.2-0.10.30.60.00.00.20.0
Pavlov. Cond. latency score0.00.10.2-0.0-0.00.30.50.10.20.2-0.10.40.5-0.20.10.3-0.1
Pavlov. Cond. lever contacts0.10.20.6-0.2-0.10.40.2-0.30.3-0.1-0.50.80.7-0.2-0.6-0.30.1
Pavlov. Cond. magazine entry number0.81.02.21.01.51.31.11.01.51.21.10.61.1-0.10.20.30.8
Pavlov. Cond. intertrial magazine entries3.75.610.22.83.23.03.12.43.12.62.31.52.8-0.80.71.41.1
Pavlov. Cond. lever-magazine prob. diff.0.00.00.2-0.2-0.10.10.30.0-0.00.1-0.10.10.4-0.00.10.3-0.2
Pavlov. Cond. response bias0.20.20.7-0.6-0.50.0-0.2-0.6-0.1-0.3-0.80.60.3-0.1-0.7-0.60.1
Time in closed arm before self-admin0.81.02.4-1.4-0.3-0.8-1.5-1.4-0.8-1.1-1.4-0.1-0.40.4-1.1-1.5-0.1
Time in closed arm after self-admin2.42.66.4-1.0-1.0-2.2-2.5-1.2-2.2-2.2-1.2-1.1-2.3-0.0-0.5-1.3-1.3
Time in open arm before self-admin2.22.45.91.7-0.4-1.30.21.4-1.4-0.30.9-1.9-1.9-1.42.12.4-2.1
Time in open arm after self-admin2.02.24.50.81.61.22.11.21.42.11.6-0.11.61.81.51.21.5
Bone: periosteal estimation2.96.014.93.93.22.83.12.72.52.42.12.11.9-2.11.02.20.2
Bone: periosteal perimeter3.05.213.53.72.82.03.02.92.02.22.30.91.3-1.71.82.6-0.2
Bone: post-yield work2.84.09.22.92.11.32.33.01.21.72.7-0.90.5-0.22.62.7-0.3
Progressive ratio test 1 active lever presses0.91.12.30.61.51.31.30.91.41.41.00.71.20.30.40.60.7
Progressive ratio test 1 breakpoint1.11.32.70.81.61.61.51.01.61.51.00.81.40.30.40.60.9
Progressive ratio test 1 inactive lever presses1.62.34.41.62.02.12.11.32.11.71.21.11.9-0.00.30.61.2
Progressive ratio test 2 active lever presses1.72.04.21.12.11.71.81.51.61.91.60.31.60.40.91.00.9
Progressive ratio test 2 breakpoint1.92.24.51.12.11.81.91.51.72.01.70.31.70.50.91.01.0
Progressive ratio test 2 inactive lever presses1.52.44.11.61.81.92.01.81.71.92.0-0.11.80.71.11.11.1
Incentive Sensitization - Responses1.62.23.91.31.71.81.91.91.32.01.9-0.11.4-0.41.11.60.5
Incentive Sensitization - Breakpoint1.72.24.01.21.71.82.01.91.42.01.9-0.11.5-0.21.11.60.7
Sum of active levers in priming session hrs 5-60.60.52.9-1.7-1.0-0.10.0-0.7-0.10.4-0.10.00.31.2-0.2-0.31.0
Progressive ratio0.30.52.2-0.50.60.80.30.10.60.70.30.40.91.1-0.2-0.81.5
Food seeking constrained by brief footshock1.62.06.20.01.31.51.30.71.61.71.20.31.72.20.8-0.32.5
Seeking ratio, punishment vs. effort0.20.30.80.50.50.50.90.40.80.70.60.10.60.40.70.60.3
Retroperitoneal fat weight0.00.20.5-0.10.70.50.1-0.00.40.3-0.30.40.60.6-0.2-0.30.3
Reaction time number correct0.20.31.00.50.00.00.20.8-0.40.00.4-0.7-0.2-0.80.51.0-0.8
Reaction time mean minus median0.10.20.60.10.10.50.60.10.60.50.30.40.80.50.10.10.4
Reaction time mean minus median AUC0.20.51.1-0.8-1.0-0.0-0.3-1.0-0.1-0.4-1.00.90.3-0.0-1.0-0.80.1
Reaction time num false alarms1.11.53.91.72.01.51.41.71.21.11.40.20.6-0.60.91.10.1
Reaction time num false alarms AUC0.91.43.31.71.81.51.41.61.21.11.20.30.8-0.70.80.90.2
Reaction time trials correct on left0.20.31.00.50.00.00.20.8-0.40.00.4-0.7-0.2-0.80.51.0-0.8
Reaction time trials on left0.20.31.00.50.10.10.30.9-0.30.10.4-0.6-0.1-0.90.51.0-0.8
Reaction time mean0.40.61.2-1.0-1.10.2-0.0-1.00.3-0.2-0.71.11.00.4-1.0-0.80.3
Reaction time mean AUC0.50.72.0-1.2-1.40.0-0.2-1.20.1-0.4-0.91.00.90.5-1.1-0.90.2
Median of all reaction times0.40.61.5-0.9-1.20.2-0.0-1.00.2-0.3-0.71.11.00.2-1.1-0.70.2
Reaction time omissions1.11.66.70.2-0.01.71.1-0.11.80.6-0.52.62.0-1.2-1.5-0.60.6
Reaction time false alarm rate0.60.92.31.21.51.31.10.91.20.90.90.70.7-0.20.40.30.5
Reaction time premature initiation rate0.60.81.81.11.31.41.10.71.20.90.60.70.80.00.1-0.11.1
Reaction time premature initiations0.61.02.61.31.31.61.31.11.21.00.80.50.9-0.10.30.21.0
Std. dev. reaction times0.30.61.5-1.0-0.80.3-0.1-1.20.3-0.2-0.91.20.90.4-1.2-1.00.4
Reaction time trials completed0.20.31.00.50.10.10.30.9-0.30.10.4-0.6-0.1-0.90.51.0-0.8
Reaction time trials AUC0.10.30.80.40.10.10.30.8-0.30.10.3-0.7-0.1-0.80.50.9-0.6
Run reversals in cocaine runway, females2.12.16.31.80.8-1.00.51.7-0.90.11.1-1.9-0.9-0.71.92.5-2.2
Run reversals in cocaine runway, males0.60.62.01.40.70.40.71.20.40.40.8-0.2-0.2-1.30.61.0-0.5
Latency to leave start box in cocaine runway0.20.20.80.4-0.3-0.9-0.4-0.2-0.4-0.5-0.2-0.4-0.4-0.50.30.2-0.6
Latency to leave start box in cocaine runway, F1.21.43.71.5-0.2-1.4-0.20.6-0.9-0.60.5-1.3-1.3-1.31.51.6-1.9
Latency to leave start box in cocaine runway, M1.21.23.6-1.3-0.20.3-0.3-1.30.6-0.0-1.11.11.00.8-1.5-1.91.5
Std. dev. time between licks in bursts0.30.41.40.10.30.20.40.7-0.10.70.9-1.20.11.01.00.70.4
Total sessions with >9 infusions0.70.92.10.41.10.40.71.40.31.11.4-0.90.00.71.31.30.1
Short access day 1 total inactive lever presses1.21.53.31.51.71.21.21.80.91.01.40.00.4-1.40.81.7-0.8
Short access day 10 total inactive lever presses0.61.43.81.90.91.51.71.41.21.11.10.31.1-0.70.71.30.1
Short access day 1 total infusions0.20.20.8-0.20.90.90.30.50.60.70.50.40.40.1-0.10.10.3
Short access day 10 total infusions0.71.01.70.81.11.21.21.21.01.21.3-0.10.90.50.80.80.8
Short access total infusions0.50.61.80.51.31.00.81.00.91.01.00.20.60.10.40.70.3
Short access day 1 locomotion1.21.53.51.31.41.41.41.91.21.41.60.00.5-0.50.91.30.2
Short access day 10 total locomotion2.95.310.02.52.42.43.22.62.62.72.9-0.12.41.21.91.52.0
Short access total locomotion4.04.89.02.62.22.12.93.02.22.53.0-0.51.50.52.22.31.0
One hour access (0.3 mA shock)0.40.51.20.90.50.40.91.10.20.70.8-0.50.3-0.11.01.00.1
Compulsive drug intake0.40.51.60.0-0.8-0.9-0.5-0.2-0.6-0.9-1.0-0.1-0.9-0.90.00.3-1.3
One hour access (shock baseline)1.21.84.11.21.41.21.51.70.91.72.0-0.71.00.81.51.31.0
Social response proportion2.12.46.61.71.10.11.22.2-0.21.12.0-2.2-0.30.02.42.6-0.9
Social responses0.50.61.91.10.41.20.91.40.50.61.2-0.60.4-0.20.70.60.4
Social time2.02.77.01.91.10.71.92.50.51.62.4-1.50.5-0.22.22.6-0.5
Soleus weight0.51.34.11.10.5-0.40.81.5-0.50.71.5-1.7-0.5-0.11.92.0-0.8
Bone: stiffness0.10.10.40.60.60.4-0.00.20.30.10.20.4-0.2-0.0-0.1-0.20.3
Tibialis anterior weight0.62.24.90.21.50.41.21.50.41.81.9-2.00.52.12.21.41.2
Time to tail flick, vehicle, before self-admin1.61.74.5-0.5-0.9-1.0-1.4-1.2-0.8-1.3-1.90.8-1.6-2.1-1.3-0.4-1.7
Time to tail flick, vehicle, after self-admin0.50.71.80.21.21.30.60.21.40.70.11.20.90.6-0.5-0.50.7
Time to tail flick, test, before self-admin0.40.41.4-0.9-0.1-0.8-0.5-0.1-0.60.10.1-1.0-0.51.20.70.6-0.4
Time to tail flick, test, after self-admin0.10.10.3-0.30.50.40.10.10.40.50.20.10.40.40.00.10.4
Delta time to tail flick, vehicle, before/after SA2.42.35.20.81.62.31.81.32.01.71.40.82.11.30.30.21.6
Delta time to tail flick, test, before/after SA0.70.72.30.30.61.50.90.51.10.90.50.91.2-0.6-0.5-0.11.0
Tibia length0.30.83.41.30.1-0.8-1.0-0.0-1.1-1.2-0.5-0.3-1.8-0.80.1-0.4-0.8
Ambulatory time before self-admin0.10.10.8-0.40.20.50.3-0.20.50.4-0.30.90.2-0.3-0.3-0.10.0
Ambulatory time after self-admin0.10.10.30.1-0.2-0.10.2-0.30.5-0.1-0.10.3-0.00.5-0.0-0.50.4
Bone: tissue strength0.70.71.6-0.5-1.2-0.6-1.2-0.8-0.8-1.2-0.5-0.3-1.20.4-0.6-1.2-0.1
Total heroin consumption0.60.71.7-0.50.01.21.00.01.31.10.01.21.30.2-0.4-0.21.2
Bone: trabecular number1.01.66.91.90.11.30.90.01.1-0.1-0.92.61.0-2.2-1.4-0.3-0.3
Bone: trabecular spacing0.71.04.5-1.00.2-0.10.20.50.20.81.3-1.7-0.12.11.10.11.2
Bone: trabecular thickness0.91.14.62.10.90.50.70.90.30.00.20.90.1-2.10.21.2-1.4
Bone: trabecular tissue density0.71.12.1-0.3-1.2-1.0-1.2-1.0-1.0-1.4-1.20.5-0.9-1.1-1.1-0.7-1.3
Water consumed over 24 hours0.30.41.00.20.2-0.8-0.8-0.0-0.8-0.7-0.3-0.5-1.0-0.70.10.1-1.0
Number of responses in last shaping day1.92.05.12.31.61.71.61.91.61.21.80.40.6-0.91.11.4-0.1