Hub : Genes

Nsf

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Nsf 0.07 0.03 7.5e-07 0.05 0.03 0.01 0.06 2.0e-06 2.2e-04 1.1e-02 1.0e-06
2 LHb gene expression Nsf 0.32 0.12 1.1e-03 0.1 0.12 0.09 0.13 2.6e-03 9.1e-04 4.5e-03 5.2e-04
3 PL gene expression Nsf 0.07 0.04 2.2e-05 0.06 0.03 0.04 0.04 8.1e-07 2.0e-04 9.1e-05 2.6e-05
4 NAcc mRNA stability Nsf 0.03 0.02 8.1e-03 0.03 0.01 0.01 0.02 3.8e-04 4.2e-02 7.2e-03 2.7e-03
5 BLA mRNA stability Nsf 0.19 0.08 6.1e-06 0.05 0.08 0.09 0.09 1.4e-03 3.1e-05 1.3e-05 1.6e-05
6 Brain mRNA stability Nsf 0.13 0.05 3.1e-11 0.08 0.13 0.12 0.11 7.6e-08 8.7e-12 3.2e-11 1.2e-10
7 PL mRNA stability Nsf 0.05 0.03 6.7e-04 0.03 0.02 0.02 0.02 2.6e-04 2.3e-03 9.5e-04 1.1e-03
8 NAcc gene expression Nsf 0.13 0.05 0.0e+00 0.18 0.17 0.18 0.18 1.2e-20 7.7e-20 6.4e-20 4.9e-20
9 Liver mRNA stability Nsf 0.04 0.03 6.1e-04 0.01 0.02 0.02 0.02 7.1e-03 2.9e-03 1.2e-03 3.1e-03
10 Adipose mRNA stability Nsf 0.32 0.09 0.0e+00 0.26 0.24 0.25 0.25 1.6e-28 1.4e-26 3.9e-27 8.5e-28
11 pVTA mRNA stability Nsf 0.21 0.16 3.4e-03 0.07 0.01 0.09 0.04 7.7e-04 1.3e-01 1.6e-04 8.1e-03
12 Brain gene expression Nsf 0.25 0.11 0.0e+00 0.11 0.2 0.19 0.19 1.2e-10 6.8e-18 4.0e-17 1.4e-17
13 Adipose gene expression Nsf 0.4 0.1 0.0e+00 0.06 0.17 0.16 0.16 9.7e-07 2.7e-18 1.7e-17 2.8e-17

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density1.22.06.80.8-0.3-1.8-0.7-0.1-0.40.0-2.6-0.32.52.2-1.6-0.9
Area under the delay curve0.20.20.50.10.7-0.30.0-0.30.7-0.60.5-0.1-0.10.00.70.1
BMI with tail0.92.88.7-1.12.1-1.00.7-0.51.0-1.92.91.7-1.6-1.23.0-0.3
BMI without tail0.40.93.50.31.90.1-0.9-0.80.9-0.70.4-0.1-1.50.10.71.5
Body weight1.24.816.31.34.0-2.6-1.5-2.42.5-3.31.20.0-1.1-1.22.80.6
Weight adjusted by age0.50.61.40.51.1-0.5-0.2-0.81.0-1.20.6-0.10.4-0.81.0-0.4
Bone surface2.34.112.52.31.8-3.5-1.9-1.71.2-1.7-2.9-1.33.01.1-0.4-0.7
Bone volume1.83.18.61.81.3-2.9-1.5-1.10.7-1.1-2.9-0.92.91.7-0.9-0.6
Breakpoint value in progressive ratio session1.01.12.41.41.00.4-1.2-1.01.3-0.2-0.9-1.4-1.1-0.50.11.6
Number of licking bursts0.91.13.7-0.41.0-0.50.5-0.40.8-1.31.90.6-0.9-1.41.9-0.4
Context. condit. distance diff. score0.30.31.2-0.60.10.31.10.5-0.1-0.10.80.9-0.4-0.40.6-0.1
Locomotion velocity, session 10.20.31.00.5-0.00.2-0.5-0.1-0.00.3-1.0-0.70.20.6-0.80.6
Locomotion distance, session 10.10.10.30.4-0.10.2-0.4-0.0-0.1-0.0-0.5-0.4-0.10.3-0.50.2
Locomotion velocity, session 20.91.03.0-0.0-1.10.70.20.8-0.91.4-1.7-0.50.71.3-1.7-0.0
Locomotion distance, session 20.30.51.40.6-0.40.8-0.50.10.00.6-1.0-0.8-0.60.1-1.01.2
Locomotion velocity, session 30.80.91.9-1.0-0.8-0.70.90.8-1.20.5-0.21.11.41.2-0.4-1.2
Locomotion distance, session 30.60.61.9-0.8-0.5-0.91.00.5-0.6-0.10.41.11.00.40.5-1.4
Stereotopy head waving bouts, day 31.92.35.7-1.3-1.30.31.31.8-1.71.7-1.01.31.62.4-1.8-1.0
Stereotopy head waving duration, day 30.70.81.8-0.8-0.70.80.81.2-0.91.2-0.50.60.31.3-1.3-0.2
Locomotion velocity, session 70.80.81.6-1.2-0.70.61.11.2-1.30.90.21.20.31.0-0.5-0.6
Locomotion distance, session 70.20.20.7-0.6-0.30.40.90.6-0.40.70.10.4-0.10.4-0.20.1
Stereotopy head waving bouts, day 71.01.22.4-0.9-1.1-0.11.21.2-1.11.0-0.50.81.41.3-1.1-1.5
Stereotopy head waving duration, day 71.51.83.4-1.3-1.81.11.51.8-1.71.8-0.20.80.51.2-1.4-1.1
Locomotion velocity, session 80.50.62.50.71.30.2-0.6-0.40.7-0.6-0.1-0.2-1.0-0.70.11.6
Locomotion distance, session 80.20.31.40.1-0.41.20.40.5-0.20.6-0.3-0.1-0.9-0.2-0.60.9
Degree of sensitization distance0.90.92.50.81.00.6-0.7-0.81.1-0.50.2-1.0-1.5-1.10.21.6
Degree of sensitization stereotypy0.70.81.6-0.9-1.20.21.11.1-1.10.9-0.10.70.80.6-0.6-1.3
Conditioned locomotion0.10.10.4-0.1-0.30.60.30.4-0.20.5-0.10.3-0.50.2-0.40.3
Cocaine response after cond. corrected1.01.13.4-1.00.3-1.60.80.6-0.5-0.30.31.41.80.90.5-1.8
Cocaine response after cond. not corrected1.31.45.9-0.9-0.1-1.60.70.7-0.90.1-0.41.22.41.4-0.1-2.0
Cocaine response before conditioning0.40.52.30.4-0.80.1-0.40.2-0.50.8-1.5-0.70.80.7-1.10.0
Saline control response1.01.35.21.20.90.7-1.2-0.91.2-0.5-0.1-1.0-1.6-1.30.32.3
Bone: connectivity density1.32.06.81.3-0.0-1.9-1.3-0.60.1-0.2-2.6-1.02.41.6-1.4-0.7
Bone: cortical apparent density4.96.412.5-2.4-3.53.32.23.3-3.13.5-0.41.5-0.22.6-2.6-0.8
Bone: cortical area1.21.87.01.01.2-2.6-0.7-0.60.3-1.1-1.7-0.12.51.3-0.3-1.0
Bone: cortical porosity7.58.221.63.53.6-4.6-3.4-3.32.9-3.2-2.4-1.92.8-0.70.90.7
Bone: cortical porosity5.45.918.52.63.2-4.3-2.6-2.82.4-3.1-1.5-1.12.5-0.81.20.3
Bone: cortical thickness2.84.58.9-1.9-2.0-0.72.02.2-2.71.3-0.62.52.73.0-1.4-2.9
Bone: cortical thickness3.44.07.6-1.6-2.1-0.22.02.1-2.31.7-1.01.62.72.8-1.6-2.7
Bone: cortical tissue density4.66.112.2-2.3-3.43.32.13.2-3.03.5-0.41.4-0.32.5-2.5-0.7
Condit. Reinf. active minus inactive responses1.41.63.41.81.1-0.7-1.7-1.61.6-0.9-1.1-1.8-0.2-0.90.21.0
Condit. Reinf. active-inactive response ratio0.50.51.41.00.5-0.3-0.7-1.01.1-0.5-0.5-1.2-0.2-0.80.40.4
Condit. Reinf. active responses1.31.63.71.91.0-0.3-1.9-1.41.4-0.5-1.6-1.9-0.3-0.4-0.41.6
Condit. Reinf. inactive responses0.50.62.40.60.30.1-0.80.1-0.10.5-1.6-0.40.41.2-1.31.0
Incentive salience index mean1.11.43.41.80.7-0.7-1.7-1.41.3-0.6-1.6-1.80.2-0.5-0.10.8
Condit. Reinf. lever presses0.30.41.90.9-0.3-0.1-1.0-0.40.10.2-1.4-0.80.20.1-0.60.6
Condit. Reinf. active minus inactive responses1.82.36.02.21.1-1.3-2.0-1.51.2-0.7-2.5-2.21.40.4-0.80.6
Condit. Reinf. active-inactive response ratio1.71.84.61.81.1-1.4-1.9-1.71.4-1.0-1.4-2.11.00.0-0.00.2
Condit. Reinf. active responses2.43.38.92.81.3-0.9-2.3-1.71.5-0.5-3.0-2.90.90.3-1.21.4
Condit. Reinf. inactive responses1.31.66.21.60.20.8-1.1-0.20.30.7-2.5-1.7-0.20.6-1.91.8
Condit. Reinf. lever presses0.60.82.71.30.3-0.2-1.4-0.70.5-0.0-1.6-1.50.40.3-0.70.7
Condit. Reinf. lever reinforcers received1.82.68.02.41.1-0.9-2.0-1.31.2-0.4-2.8-2.51.10.6-1.21.0
Conditioned reinforcement - actives1.01.02.20.81.0-0.0-0.9-1.01.3-0.80.7-0.8-1.5-1.50.91.0
Conditioned reinforcement - inactives0.70.81.91.41.1-0.4-1.3-0.80.8-0.6-1.2-0.90.6-0.7-0.60.7
Conditioned locomotion1.21.52.71.41.5-1.4-1.2-1.51.6-1.60.3-0.70.1-1.51.00.5
Patch foraging indifference point 0 sec0.91.56.61.50.30.4-0.90.10.10.5-2.6-0.90.51.1-2.21.6
Patch foraging indifference point AUC1.11.32.51.11.6-0.2-0.9-1.21.5-1.10.4-0.9-1.4-1.50.91.0
Delay disc. indifference point, 0s delay0.10.10.50.1-0.50.70.30.20.20.20.0-0.2-0.6-0.1-0.20.5
Delay disc. indifference point, 16s delay0.60.61.3-0.51.1-1.10.6-0.10.5-0.91.00.70.70.31.1-0.8
Delay disc. indifference point, 2s delay0.70.82.21.30.1-0.3-1.4-0.80.7-0.3-1.2-1.50.50.6-0.80.4
Delay disc. indifference point, 24s delay0.70.72.10.71.5-0.4-0.5-1.01.2-1.00.4-0.8-0.5-0.51.10.5
Delay disc. indifference point, 4s delay0.10.10.4-0.20.6-0.00.40.20.3-0.20.30.30.50.30.2-0.3
Delay disc. indifference point, 8s delay0.30.30.9-0.6-0.60.50.50.6-0.50.60.10.30.30.9-0.3-0.4
Indifference point function ln k0.81.04.20.2-0.6-0.8-0.10.4-0.80.4-1.5-0.12.01.6-1.3-0.9
Indifference point function log k0.81.04.20.2-0.6-0.8-0.10.4-0.80.4-1.5-0.12.01.6-1.3-0.9
Patch foraging total patch changes 0 sec1.01.56.71.70.6-0.1-1.1-0.10.20.2-2.6-0.90.71.1-2.01.5
Patch foraging total patch changes 12 sec1.52.06.92.10.60.9-1.4-0.71.00.0-1.8-1.7-0.9-0.6-1.62.6
Patch foraging total patch changes 18 sec0.40.51.71.11.3-0.6-0.5-0.60.8-0.9-0.7-0.40.4-0.70.00.6
Patch foraging total patch changes 24 sec0.81.04.11.30.9-0.1-0.8-0.20.20.1-2.0-0.70.90.8-1.71.0
Patch foraging total patch changes 6 sec0.20.41.11.00.9-0.1-0.6-0.20.4-0.3-1.0-0.40.10.2-0.70.7
Patch foraging time to switch 0 sec0.10.10.4-0.0-0.40.3-0.2-0.30.10.00.3-0.4-0.5-0.60.40.5
Patch foraging water rate 0 sec0.20.41.20.31.1-0.80.20.20.1-0.4-0.60.60.90.9-0.4-0.4
Patch foraging water rate 12 sec1.62.49.7-1.4-0.1-1.12.11.3-1.0-0.51.02.02.30.90.3-3.1
Patch foraging water rate 18 sec1.62.25.4-1.0-1.00.41.31.9-1.81.3-0.91.41.72.3-1.8-1.3
Patch foraging water rate 24 sec1.21.73.1-1.3-1.30.41.21.6-1.81.3-0.31.31.51.7-1.2-1.3
Patch foraging water rate 6 sec0.50.73.80.40.3-1.2-0.1-0.0-0.1-0.5-0.90.11.90.9-0.6-1.2
Seeking ratio, delayed vs. immediate footshock2.22.65.61.01.2-1.1-0.9-1.91.9-1.91.5-1.0-1.8-2.42.20.9
Distance traveled before self-admin0.50.51.60.81.3-0.2-0.7-0.81.2-0.8-0.1-0.5-0.4-0.51.00.3
Distance traveled after self-admin0.40.51.7-0.00.7-0.7-0.2-0.60.6-0.80.90.0-0.7-1.01.30.1
Extensor digitorum longus weight1.45.522.7-1.60.31.61.5-0.10.8-1.04.81.8-3.9-2.83.60.4
Bone: elastic displacement0.70.82.3-0.5-1.3-0.80.60.6-0.90.3-0.40.81.50.9-0.4-1.5
Bone: elastic work0.60.72.90.7-0.2-1.5-0.5-0.4-0.1-0.4-1.4-0.11.70.7-0.5-0.7
Bone: endosteal estimation4.49.619.34.04.4-3.5-3.5-3.94.0-3.4-1.7-3.10.6-1.91.81.7
Bone: endosteal perimeter6.413.429.74.45.5-4.3-3.9-4.54.8-4.4-1.3-3.30.5-2.52.62.0
Epididymis fat weight0.41.04.40.52.1-0.7-0.6-1.01.1-1.30.6-0.4-1.1-0.21.10.3
Delta time in closed arm before/after self-admin0.70.63.0-1.2-0.5-0.20.80.8-1.0-0.21.01.7-0.10.10.4-0.4
Delta time in open arm before/after self-admin1.11.04.30.6-0.11.6-0.8-0.30.71.0-0.7-1.2-2.1-0.1-0.31.5
Diff in mean of infusions in LGA sessions0.90.91.81.11.2-0.2-1.0-1.01.3-0.7-0.4-0.9-1.3-0.90.81.1
Delay discount exponential model param0.30.31.0-0.3-1.00.40.20.6-0.90.8-0.50.30.30.2-0.8-0.3
Extinction: sum of active levers before priming0.30.31.50.2-0.10.5-0.4-0.40.2-0.30.3-0.3-1.2-0.90.21.0
Active lever presses in extinction session 62.22.14.41.72.1-1.2-1.9-1.92.1-1.5-0.5-1.4-0.8-0.61.11.0
Bone: final force0.91.44.70.5-0.0-1.2-0.10.3-0.60.3-2.10.32.22.2-1.4-0.7
Bone: final moment1.01.65.40.5-0.1-1.3-0.20.3-0.60.3-2.30.22.32.3-1.5-0.7
Food consumed during 24 hour testing period1.21.55.11.02.3-0.8-0.8-1.21.5-1.70.5-0.5-0.7-1.31.30.9
Glucose0.50.71.7-1.3-0.50.81.31.0-0.80.41.01.1-0.30.20.3-0.7
Heart weight1.62.26.00.82.2-2.1-0.4-1.51.6-2.41.20.3-0.2-1.22.2-0.3
Delay discount hyperbolic model param0.20.20.7-0.4-0.80.20.30.5-0.80.6-0.20.40.1-0.1-0.4-0.3
Intermittent access intake day 1-15 change0.40.41.80.6-0.0-0.5-0.5-0.40.1-1.00.20.20.6-1.30.10.6
Intermittent access intake escalation0.20.21.10.0-0.1-0.30.1-0.1-0.2-0.90.70.60.5-1.10.20.1
Intermittent access intake escalation 20.20.20.60.20.3-0.7-0.6-0.50.1-0.80.30.20.2-0.60.30.5
Intermitt. access day 1 inactive lever presses2.02.15.21.81.5-2.1-2.3-1.91.5-1.4-0.9-1.40.8-0.40.30.7
Intermitt. access day 15 inactive lever presses2.93.27.52.71.8-1.6-2.2-1.91.7-1.1-2.3-2.41.9-0.2-0.50.2
Intermitt. access escalation Index0.40.30.9-0.7-0.30.20.60.20.00.10.90.6-1.0-0.30.9-0.1
Intermittent access day 1 total infusions0.60.71.60.81.2-0.7-0.5-0.91.3-1.10.5-0.3-0.3-1.00.90.3
Intermittent access day 15 total infusions0.91.04.40.90.7-0.5-0.6-0.81.1-1.40.90.0-0.6-2.10.91.1
Intermittent access terminal intake (last 3 days)1.41.64.01.71.4-0.8-1.1-1.31.7-1.60.2-0.7-0.2-2.00.71.3
Intermittent access total infusions1.01.11.91.01.2-0.8-1.1-1.11.4-1.30.6-0.4-0.6-1.40.91.1
Intermittent access day 1 locomotion2.42.54.51.62.1-1.7-1.7-2.02.0-2.10.6-0.8-0.3-1.81.50.9
Intermittent access day 15 total locomotion1.41.53.01.41.4-1.0-1.4-1.41.4-1.70.5-0.6-0.5-1.70.81.3
Intermittent access total locomotion3.33.76.52.12.4-2.2-2.4-2.52.4-2.60.4-1.2-0.1-2.11.51.3
Intermittent access standard deviation1.01.13.31.60.3-0.2-1.8-1.00.7-0.8-1.1-1.2-0.0-0.8-0.71.5
Left kidney weight0.51.56.5-0.30.5-2.60.4-0.40.3-1.40.91.01.4-0.21.7-1.8
Right kidney weight0.41.24.2-0.80.3-2.10.80.0-0.2-1.00.81.61.00.41.2-1.8
Cocaine induced anxiety1.21.46.4-0.60.1-1.50.90.5-0.7-0.70.41.52.50.30.0-2.1
Post-drug Anxiety1.51.65.3-0.11.3-2.30.4-0.50.5-1.71.11.01.5-0.41.5-1.9
Baseline Anxiety0.30.31.50.00.80.0-0.3-0.50.6-0.10.4-0.5-1.20.20.90.2
Tail length0.41.43.01.61.7-0.4-1.7-1.21.0-0.5-1.4-1.4-0.30.5-0.41.4
Length with tail0.72.66.41.92.5-2.5-1.7-1.91.7-2.2-0.8-0.80.8-0.00.80.0
Length without tail0.71.66.90.71.3-2.6-0.1-0.90.8-2.00.10.51.5-0.21.0-1.4
Times rat made contact with spout0.10.10.4-0.10.6-0.50.00.00.1-0.40.10.60.3-0.20.40.0
Lifetime Intake1.11.22.21.51.4-1.0-1.3-1.31.5-1.30.0-0.8-0.2-1.20.51.0
Liver weight, left0.40.62.60.60.4-0.0-0.20.00.10.4-1.6-0.60.71.3-1.40.3
Liver weight, right1.42.44.4-1.5-1.40.51.72.0-1.91.2-0.41.81.52.1-1.3-1.6
Locomotor activity1.42.24.72.00.8-0.2-2.1-1.71.5-0.7-1.2-2.1-0.9-1.4-0.22.2
Locomotor testing distance2.94.910.93.21.3-0.1-3.1-2.52.2-1.0-2.1-3.3-1.0-1.6-0.63.2
Locomotor testing rearing2.74.112.52.80.60.7-2.3-1.92.0-0.7-1.5-2.7-1.9-2.4-0.33.5
Locomotion in novel chamber1.21.43.51.51.9-1.1-0.7-1.11.8-1.6-0.2-0.80.5-1.50.90.4
Locomotion in novel chamber post-restriction0.50.61.30.81.2-0.9-1.1-0.70.6-0.4-0.7-0.81.00.2-0.30.6
Fecal boli incidents, locomotor time 10.10.10.5-0.7-0.20.40.30.3-0.50.20.70.3-0.20.00.10.0
Change in fecal boli incidents, locomotor task0.10.10.50.20.6-0.7-0.2-0.40.5-0.50.10.10.30.10.4-0.2
Time >=10cm from walls, locomotor time 11.01.03.3-1.2-0.9-0.21.40.9-0.90.40.41.01.30.30.2-1.8
Bouts of movement, locomotor time 10.80.82.2-1.4-0.40.31.50.9-0.90.11.11.00.30.40.2-1.5
Total resting periods, locomotor time 11.01.13.5-1.5-0.3-0.11.70.9-1.0-0.11.31.20.70.40.3-1.9
Rest time, locomotor task time 11.21.32.8-1.2-1.70.51.21.3-1.51.5-0.10.61.01.1-1.1-1.2
Distance moved, locomotor task time 11.01.12.20.91.5-0.7-1.1-1.21.4-1.40.5-0.4-0.9-1.11.20.8
Vertical activity count, locomotor time 10.50.51.20.61.1-1.0-0.6-0.80.9-1.10.3-0.10.1-0.30.90.1
Time >=10cm from walls, locomotor time 20.40.52.20.60.5-1.0-0.0-0.40.5-0.9-0.4-0.11.5-0.70.3-0.6
Bouts of movement, locomotor time 20.50.51.8-0.60.0-0.50.20.3-0.70.5-0.00.21.31.3-0.3-1.1
Total resting periods, locomotor time 20.80.92.3-1.1-0.4-0.40.70.7-1.10.70.20.71.51.4-0.3-1.5
Rest time, locomotor task time 20.80.92.5-1.6-0.7-0.31.30.8-0.90.41.21.30.30.20.4-1.1
Distance moved, locomotor task time 20.20.20.50.70.40.1-0.6-0.50.6-0.60.0-0.4-0.4-0.70.30.5
Vertical activity count, locomotor time 20.40.41.21.10.2-0.0-0.9-0.50.5-0.2-1.0-0.90.30.2-0.50.5
Light reinforcement 10.61.03.71.2-0.50.1-0.8-0.3-0.00.6-1.9-1.20.60.8-1.81.1
Light reinforcement 20.91.24.20.5-0.6-0.2-0.9-0.1-0.40.8-2.0-0.81.21.9-1.90.2
Bone: marrow area4.39.319.03.94.4-3.5-3.4-3.83.9-3.4-1.7-3.00.6-1.81.71.7
Bone: maximum diameter1.83.38.72.42.5-2.9-1.7-1.71.8-1.9-2.1-1.31.90.20.30.3
Bone: maximum force0.71.24.61.11.1-2.1-0.9-0.80.5-1.1-1.4-0.11.81.0-0.3-0.4
Bone: maximum moment0.81.44.81.11.0-2.2-0.9-0.70.3-0.9-1.7-0.22.01.3-0.4-0.5
Mean time between licks in bursts1.31.86.2-0.81.4-1.10.9-0.40.6-1.62.51.3-0.7-1.22.3-0.9
Mean num. licks in bursts0.50.72.50.2-0.50.1-0.50.3-0.60.8-1.6-0.20.91.2-1.30.3
Cd content in liver1.51.66.2-1.2-1.62.51.31.2-0.71.41.20.6-1.9-0.1-0.10.2
Co content in liver0.91.12.90.8-0.41.0-0.7-1.01.1-0.00.4-1.5-1.7-1.60.71.2
Cu content in liver0.30.41.31.00.5-0.3-0.7-0.71.0-0.4-0.5-1.1-0.1-0.50.00.2
Fe content in liver2.93.58.0-1.8-1.82.02.42.8-2.12.4-0.41.60.21.9-1.7-1.0
K content in liver0.60.61.90.3-0.60.3-0.10.3-0.41.0-1.4-0.90.90.9-1.2-0.3
Mg content in liver2.22.36.5-0.7-1.82.21.01.6-1.42.6-1.3-0.60.11.6-2.1-0.1
Mn content in liver2.42.88.0-0.3-2.11.10.21.4-1.92.0-2.3-0.21.22.4-2.8-0.5
Na content in liver0.80.92.91.1-0.10.8-1.1-0.30.30.8-1.5-1.7-0.20.0-1.11.2
Rb content in liver1.62.06.9-0.7-1.92.61.21.4-1.02.3-0.6-0.6-1.00.5-1.70.6
Se content in liver1.01.22.7-1.4-1.21.41.41.1-0.80.71.61.3-1.3-0.40.6-0.4
Sr content in liver1.51.45.1-1.00.7-1.70.90.1-0.1-0.81.01.41.50.11.3-2.3
Zn content in liver0.10.10.6-0.10.1-0.00.00.20.10.5-0.4-0.40.40.8-0.4-0.3
Bone: minimum diameter5.39.921.83.84.7-4.4-3.5-3.93.8-3.9-1.5-2.71.3-1.21.71.1
Time in familiar zone, hab. session 11.11.04.60.00.71.2-0.3-0.30.6-0.31.30.0-2.1-1.20.81.5
Time in novel zone, hab. session 11.11.14.5-0.4-0.8-1.20.70.5-0.70.3-0.90.52.11.1-0.5-1.8
Total zone transitions, hab. session 10.40.62.7-0.70.30.00.6-0.00.1-0.51.60.9-1.0-0.81.2-0.2
Total locomotion distance, hab. session 10.30.41.50.60.5-1.2-0.6-0.60.4-0.7-0.6-0.30.80.2-0.0-0.3
Locomotion velocity, hab. session 10.40.51.41.00.8-1.2-0.8-0.90.8-0.9-0.7-0.60.5-0.10.00.1
Time in familiar zone, hab. session 21.01.04.20.30.80.9-0.4-0.50.7-0.50.9-0.1-2.1-1.40.71.7
Time in novel zone, hab. session 22.32.38.3-0.6-1.3-1.20.90.9-1.30.8-1.40.62.92.1-1.2-2.4
Total zone transitions, hab. session 20.50.72.6-0.6-0.11.20.70.40.00.21.40.4-1.6-0.90.70.3
Total locomotion distance, hab. session 20.10.20.7-0.4-0.00.70.60.40.00.40.50.4-0.9-0.00.10.1
Locomotion velocity, hab. session 20.20.20.9-0.40.00.80.60.40.00.30.70.4-1.0-0.00.10.1
Novel to familiar place preference ratio0.30.31.00.71.0-0.8-0.4-0.60.5-0.8-0.5-0.20.7-0.10.00.0
Novelty place preference0.30.30.80.60.8-0.8-0.2-0.40.3-0.6-0.5-0.10.90.1-0.1-0.2
Time in novel zone, NPP test0.30.31.30.40.6-0.80.0-0.10.1-0.4-0.70.21.10.3-0.4-0.4
Total zone transitions, NPP test0.30.51.4-0.7-0.61.21.01.0-0.60.70.40.6-0.70.2-0.40.0
Total locomotion distance, NPP test0.20.30.90.1-0.2-0.20.40.5-0.20.3-0.90.20.70.9-0.8-0.4
Locomotion velocity, NPP test0.00.00.20.20.1-0.10.10.10.2-0.0-0.2-0.00.00.5-0.2-0.1
Intraocular pressure0.70.94.60.42.1-0.1-0.6-0.91.4-0.80.7-0.3-1.0-0.21.30.4
Delta distance traveled before/after self-admin0.30.30.8-0.9-0.70.00.50.7-0.90.50.40.7-0.10.2-0.1-0.3
Delta ambulatory time before/after self-admin0.10.20.5-0.6-0.6-0.00.20.4-0.70.30.20.5-0.40.3-0.20.1
Parametrial fat weight0.40.83.30.90.5-0.7-1.0-0.30.1-0.4-1.8-0.01.01.3-1.10.2
Pavlov. Cond. lever latency1.82.34.6-2.1-1.32.11.91.9-1.31.61.71.6-1.10.60.0-0.5
Pavlov. Cond. magazine entry latency2.12.710.12.30.7-0.9-2.3-1.20.7-0.2-3.2-2.01.20.8-1.71.3
Pavlov. Cond. change in total contacts1.92.14.82.21.0-0.8-2.2-1.61.4-0.7-2.1-2.10.4-0.2-0.61.1
Pavlov. Cond. index score2.02.56.52.51.0-1.4-2.3-1.71.2-0.9-2.5-2.11.0-0.1-0.91.1
Pavlov. Cond. latency score1.82.25.32.31.1-1.4-2.1-1.71.2-1.1-2.1-1.90.7-0.4-0.61.1
Pavlov. Cond. lever contacts1.92.24.32.11.4-1.7-2.0-2.01.6-1.6-1.3-1.70.5-1.00.40.8
Pavlov. Cond. magazine entry number2.32.912.4-2.1-0.10.22.20.7-0.4-0.63.52.2-0.9-1.42.3-1.5
Pavlov. Cond. intertrial magazine entries1.21.53.11.11.10.1-0.9-1.21.5-1.20.7-0.9-1.7-1.71.01.7
Pavlov. Cond. lever-magazine prob. diff.2.12.76.42.51.0-1.7-2.3-1.81.2-1.1-2.5-2.11.2-0.1-0.80.8
Pavlov. Cond. response bias2.42.911.52.30.6-1.4-2.3-1.20.7-0.3-3.4-2.11.71.1-1.70.7
Pavlov. Cond. lever latency0.20.20.9-0.50.10.10.60.2-0.0-0.20.90.8-0.4-0.20.5-0.1
Pavlov. Cond. magazine entry latency0.30.40.7-0.8-0.80.50.80.6-0.60.60.70.6-0.2-0.10.2-0.4
Pavlov. Cond. change in total contacts0.81.14.31.20.20.6-1.5-1.01.10.1-0.7-2.1-1.0-0.8-0.11.4
Pavlov. Cond. index score0.00.10.30.3-0.1-0.2-0.2-0.30.2-0.0-0.2-0.60.1-0.30.1-0.1
Pavlov. Cond. latency score0.10.10.40.4-0.1-0.3-0.4-0.40.2-0.1-0.3-0.60.2-0.30.1-0.1
Pavlov. Cond. lever contacts0.10.10.70.4-0.20.1-0.30.0-0.10.3-0.8-0.60.30.3-0.60.1
Pavlov. Cond. magazine entry number0.60.71.71.11.3-0.7-1.1-1.01.1-0.9-0.6-0.9-0.0-0.20.10.8
Pavlov. Cond. intertrial magazine entries3.74.88.92.93.0-2.2-3.0-2.82.6-2.4-1.6-2.40.5-0.80.51.4
Pavlov. Cond. lever-magazine prob. diff.0.00.00.20.1-0.1-0.2-0.2-0.20.10.0-0.0-0.50.1-0.20.2-0.2
Pavlov. Cond. response bias0.10.20.4-0.0-0.50.40.10.4-0.40.6-0.6-0.20.30.4-0.6-0.1
Time in closed arm before self-admin2.42.75.6-1.7-1.42.31.52.3-2.02.4-0.30.9-0.41.8-1.7-0.4
Time in closed arm after self-admin3.23.36.5-2.5-1.32.12.22.6-2.41.80.72.1-1.01.7-0.9-0.5
Time in open arm before self-admin2.22.46.2-0.70.6-2.20.9-0.60.4-2.02.31.51.1-1.62.5-1.7
Time in open arm after self-admin2.73.05.61.31.9-1.9-1.6-2.42.4-2.00.8-1.2-0.8-2.02.30.7
Bone: periosteal estimation3.06.215.73.13.4-4.0-2.6-2.82.6-2.8-2.3-2.02.2-0.20.70.3
Bone: periosteal perimeter3.15.115.52.43.1-3.9-2.1-2.62.5-2.9-1.2-1.41.9-0.51.6-0.2
Bone: post-yield work3.24.410.91.62.6-2.9-1.4-2.62.3-3.30.9-0.70.1-2.42.70.1
Progressive ratio test 1 active lever presses1.31.33.81.51.9-0.5-1.5-1.31.6-0.7-0.7-1.4-0.5-0.20.41.1
Progressive ratio test 1 breakpoint1.81.94.91.82.2-0.8-1.7-1.62.0-1.0-0.6-1.7-0.4-0.60.51.2
Progressive ratio test 1 inactive lever presses2.42.65.72.32.0-0.5-2.4-1.81.7-0.6-1.8-2.1-0.3-0.1-0.52.0
Progressive ratio test 2 active lever presses1.21.23.21.41.8-0.8-1.5-1.31.5-0.8-0.4-1.2-0.5-0.50.51.1
Progressive ratio test 2 breakpoint1.31.43.41.41.8-0.8-1.7-1.41.6-0.8-0.5-1.3-0.6-0.50.51.2
Progressive ratio test 2 inactive lever presses2.02.44.42.12.0-1.3-2.1-1.91.9-1.6-0.4-1.5-0.4-1.30.51.3
Incentive Sensitization - Responses1.01.02.21.51.0-0.6-1.4-1.21.3-0.8-0.6-1.20.1-1.10.21.1
Incentive Sensitization - Breakpoint0.90.92.01.41.0-0.5-1.3-1.11.2-0.7-0.6-1.20.1-1.10.11.1
Sum of active levers in priming session hrs 5-60.60.62.10.2-1.21.50.10.10.30.8-0.0-0.6-1.1-0.9-0.31.0
Progressive ratio0.20.21.00.40.20.6-0.2-0.10.30.0-0.1-0.6-0.5-0.7-0.31.0
Food seeking constrained by brief footshock1.51.85.71.41.30.3-1.4-1.31.5-0.6-0.5-1.4-1.9-1.30.52.4
Seeking ratio, punishment vs. effort0.20.20.50.40.5-0.4-0.7-0.70.6-0.4-0.1-0.3-0.5-0.20.70.4
Retroperitoneal fat weight0.20.73.21.01.8-0.7-0.9-0.70.8-0.9-0.5-0.4-0.50.70.20.7
Reaction time number correct0.20.30.6-0.1-0.0-0.60.3-0.10.1-0.70.50.40.7-0.80.5-0.8
Reaction time mean minus median0.10.20.60.50.1-0.1-0.8-0.50.50.0-0.4-0.7-0.4-0.10.10.4
Reaction time mean minus median AUC0.30.41.20.1-0.90.6-0.20.4-0.41.1-0.9-0.40.10.6-1.00.1
Reaction time num false alarms1.11.54.11.52.0-1.6-1.0-1.51.3-1.8-0.5-1.00.6-0.80.90.2
Reaction time num false alarms AUC1.11.53.51.61.9-1.5-1.2-1.51.2-1.6-0.7-1.10.6-0.60.60.3
Reaction time trials correct on left0.20.30.6-0.1-0.0-0.60.3-0.10.1-0.70.50.40.7-0.80.5-0.8
Reaction time trials on left0.20.20.6-0.00.0-0.70.3-0.20.1-0.70.30.30.8-0.70.5-0.7
Reaction time mean0.50.71.60.3-1.10.8-0.50.3-0.31.3-1.2-1.0-0.20.8-1.10.4
Reaction time mean AUC0.60.82.10.1-1.41.1-0.40.4-0.51.5-1.2-1.0-0.30.8-1.20.3
Median of all reaction times0.50.71.60.3-1.30.8-0.50.2-0.41.3-1.3-1.0-0.00.8-1.20.2
Reaction time omissions1.31.88.21.6-0.2-0.6-1.5-0.60.20.4-2.9-1.71.71.0-1.70.4
Reaction time false alarm rate0.71.02.61.41.6-1.1-1.2-1.21.0-1.1-0.9-1.10.3-0.10.30.6
Reaction time premature initiation rate0.60.72.01.11.2-0.9-1.4-1.00.8-0.9-0.6-0.70.1-0.3-0.01.0
Reaction time premature initiations0.60.92.01.21.1-1.0-1.4-1.10.9-1.1-0.5-0.70.2-0.80.10.9
Std. dev. reaction times0.40.61.80.3-0.70.9-0.50.4-0.31.3-1.3-0.9-0.30.8-1.20.4
Reaction time trials completed0.20.20.6-0.00.0-0.70.3-0.20.1-0.70.30.30.8-0.70.5-0.7
Reaction time trials AUC0.10.20.7-0.00.0-0.50.3-0.20.1-0.70.40.20.6-0.90.5-0.6
Run reversals in cocaine runway, females1.61.64.9-1.00.7-1.80.5-0.30.1-1.41.81.20.6-0.21.8-2.2
Run reversals in cocaine runway, males0.50.51.50.40.7-1.2-0.5-0.60.5-1.00.10.11.2-0.40.5-0.4
Latency to leave start box in cocaine runway0.40.41.2-1.1-0.2-0.20.80.4-0.50.40.60.70.11.10.5-0.7
Latency to leave start box in cocaine runway, F0.91.02.4-1.4-0.2-1.01.10.3-0.6-0.21.21.20.50.71.3-1.6
Latency to leave start box in cocaine runway, M0.70.71.9-0.3-0.51.40.10.5-0.51.3-0.7-0.5-0.41.1-1.20.8
Std. dev. time between licks in bursts0.40.41.10.20.4-0.1-0.0-0.60.7-0.81.0-0.0-1.0-1.01.00.4
Total sessions with >9 infusions0.50.51.30.90.10.0-0.9-0.80.8-0.4-0.1-0.8-1.1-1.00.21.1
Short access day 1 total inactive lever presses0.70.81.81.01.3-1.2-0.6-0.80.9-1.2-0.1-0.31.1-0.80.5-0.3
Short access day 10 total inactive lever presses1.41.54.01.50.8-2.0-1.8-1.71.1-1.6-0.3-0.90.4-1.10.50.7
Short access day 1 total infusions1.11.22.91.61.00.1-1.3-1.01.3-0.5-0.9-1.3-0.7-1.1-0.31.7
Short access day 10 total infusions2.22.44.92.21.9-1.4-1.9-1.92.0-1.7-0.6-1.50.0-1.30.51.3
Short access total infusions1.71.94.42.11.5-0.9-1.8-1.71.8-1.2-0.8-1.5-0.0-1.30.01.5
Short access day 1 locomotion2.02.14.32.11.6-1.1-2.0-1.71.7-1.5-0.8-1.40.2-1.60.21.4
Short access day 10 total locomotion7.98.818.03.33.2-2.7-4.2-4.03.6-3.30.1-2.7-1.4-2.82.02.6
Short access total locomotion6.36.512.42.92.4-2.3-3.3-3.53.1-3.00.3-2.3-1.1-3.11.92.0
One hour access (0.3 mA shock)0.60.72.10.40.5-0.9-0.5-1.00.8-1.20.9-0.2-0.2-1.41.10.3
Compulsive drug intake1.31.32.8-1.6-1.30.41.71.3-1.60.90.41.20.51.0-0.2-1.4
One hour access (shock baseline)2.02.34.71.41.7-1.3-1.4-1.82.0-2.01.0-0.7-1.0-2.21.61.2
Social response proportion1.92.15.90.11.4-1.9-0.1-1.21.3-2.22.00.5-0.1-1.82.4-0.9
Social responses0.40.62.20.90.5-1.0-0.6-0.80.6-1.20.3-0.20.2-1.50.50.3
Social time2.02.76.21.01.3-2.3-0.8-1.91.8-2.51.4-0.30.2-2.52.3-0.4
Soleus weight0.30.93.3-0.11.0-1.20.1-0.70.8-1.31.40.60.1-0.71.8-0.8
Bone: stiffness0.10.10.50.50.6-0.1-0.4-0.20.3-0.2-0.4-0.0-0.20.3-0.20.7
Tibialis anterior weight0.61.94.20.51.50.1-0.6-1.31.7-1.31.7-0.2-2.1-1.72.01.2
Time to tail flick, vehicle, before self-admin1.51.63.8-1.1-0.2-0.31.71.3-1.00.9-0.21.41.91.7-0.4-1.9
Time to tail flick, vehicle, after self-admin0.91.02.01.21.30.4-1.3-0.70.80.0-1.3-1.4-1.10.7-0.51.1
Time to tail flick, test, before self-admin1.01.02.9-1.20.10.51.20.40.1-0.11.70.9-1.6-0.61.5-0.5
Time to tail flick, test, after self-admin0.10.10.50.40.6-0.3-0.2-0.20.6-0.3-0.3-0.20.70.20.0-0.2
Delta time to tail flick, vehicle, before/after SA2.62.56.82.20.90.3-2.6-1.61.4-0.6-1.5-2.5-1.6-0.6-0.52.1
Delta time to tail flick, test, before/after SA1.21.13.11.70.4-0.4-1.2-0.70.8-0.3-1.5-1.21.6-0.2-1.20.8
Tibia length0.41.15.3-1.20.2-0.71.31.1-1.20.00.22.31.01.20.0-1.0
Ambulatory time before self-admin0.50.61.20.81.1-0.4-0.9-0.91.1-0.80.2-0.5-0.3-0.71.00.3
Ambulatory time after self-admin0.30.31.00.20.7-1.0-0.6-0.70.5-0.80.4-0.00.1-0.60.80.0
Bone: tissue strength0.60.61.5-0.8-1.00.90.61.0-1.10.70.11.2-0.40.6-0.6-0.0
Total heroin consumption0.40.51.61.30.3-0.2-0.7-0.70.9-0.4-0.7-0.90.7-0.9-0.20.6
Bone: trabecular number1.52.38.71.50.3-1.9-1.4-0.70.1-0.2-3.0-1.02.41.8-1.6-0.2
Bone: trabecular spacing1.01.34.8-0.40.21.30.2-0.10.5-0.32.00.2-2.2-1.91.21.1
Bone: trabecular thickness1.31.55.80.91.2-2.4-0.6-0.80.5-1.2-1.4-0.22.11.2-0.0-1.1
Bone: trabecular tissue density0.91.22.9-1.1-1.10.50.81.4-1.41.1-0.41.00.91.7-1.1-1.1
Water consumed over 24 hours0.70.82.0-1.20.2-0.31.31.0-0.8-0.10.61.40.90.80.2-1.4
Number of responses in last shaping day2.82.96.51.92.5-2.5-1.6-2.01.9-2.5-0.0-0.60.7-1.41.50.1