Hub : Genes

Nsd3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver mRNA stability Nsd3 0.02 0.02 5.5e-03 0 0 0 0 1.9e-01 3.4e-01 8.1e-02 2.4e-01
2 Adipose alternative TSS XM_063275247.1 0.03 0.03 2.1e-03 0.01 0.01 0.01 0.01 1.1e-02 1.0e-02 1.0e-02 1.5e-02
3 Adipose isoform ratio XM_063275247.1 0.03 0.02 3.2e-03 0.02 0.01 0.02 0.02 1.2e-03 8.1e-03 2.9e-03 2.6e-03
4 NAcc mRNA stability Nsd3 0.03 0.02 9.2e-06 0.03 0.03 0.04 0.04 4.9e-06 7.1e-06 2.3e-06 4.1e-06
5 BLA mRNA stability Nsd3 0.09 0.07 3.3e-03 0.04 0.04 0.03 0.04 5.5e-03 5.8e-03 7.1e-03 5.7e-03
6 Adipose alternative TSS XM_063275247.1 0.04 0.03 5.0e-04 0.02 0.02 0.02 0.02 1.9e-03 3.2e-03 2.6e-03 2.6e-03
7 PL mRNA stability Nsd3 0.21 0.15 6.9e-05 0.04 0.03 0.04 0.04 4.2e-05 5.3e-04 2.3e-05 4.5e-05
8 Adipose mRNA stability Nsd3 0.04 0.03 4.8e-04 0.01 0.01 0.02 0.01 1.4e-02 9.9e-03 6.3e-03 2.9e-02
9 Brain mRNA stability Nsd3 0.05 0.04 1.8e-03 0.03 0.03 0.03 0.03 3.4e-04 4.0e-04 1.1e-03 4.3e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density2.44.26.81.81.91.72.31.91.91.82.32.6
Area under the delay curve0.30.31.7-0.40.10.4-0.2-0.2-0.1-0.6-1.3-0.5
BMI with tail0.20.81.7-0.9-0.7-1.1-0.9-0.6-0.2-1.3-1.1-0.8
BMI without tail0.10.20.5-0.10.1-0.7-0.00.50.7-0.50.4-0.5
Body weight0.10.41.2-0.7-0.3-0.8-0.6-0.20.2-0.4-1.0-1.1
Weight adjusted by age1.01.52.3-1.5-1.2-0.7-1.3-1.4-1.4-0.8-1.0-1.5
Bone surface1.12.03.61.11.21.21.71.31.21.31.51.9
Bone volume1.83.35.01.51.71.62.21.71.61.81.82.2
Breakpoint value in progressive ratio session0.20.30.9-0.4-0.6-0.5-0.2-0.5-0.60.4-0.9-0.0
Number of licking bursts0.71.13.80.80.91.41.10.50.61.90.30.8
Context. condit. distance diff. score1.82.24.21.31.51.21.51.61.52.11.60.7
Locomotion velocity, session 10.20.20.7-0.1-0.3-0.70.0-0.30.10.8-0.1-0.4
Locomotion distance, session 11.92.44.2-2.0-1.6-2.1-1.3-1.2-1.2-0.5-1.4-1.9
Locomotion velocity, session 20.20.31.50.00.40.10.30.50.5-1.2-0.10.0
Locomotion distance, session 22.53.54.9-2.2-1.9-2.1-1.8-1.6-1.7-1.7-1.8-1.9
Locomotion velocity, session 31.71.95.9-1.4-1.2-1.1-1.4-1.2-1.1-2.4-0.5-1.3
Locomotion distance, session 30.00.00.20.00.00.20.0-0.1-0.0-0.30.30.4
Stereotopy head waving bouts, day 30.60.73.1-0.5-0.7-0.5-0.9-0.8-0.7-1.8-0.7-0.3
Stereotopy head waving duration, day 30.10.10.30.50.10.10.1-0.00.1-0.2-0.00.4
Locomotion velocity, session 70.30.30.9-0.5-0.3-0.7-0.30.1-0.1-1.00.1-0.9
Locomotion distance, session 70.10.10.30.60.2-0.10.30.40.50.20.5-0.1
Stereotopy head waving bouts, day 70.10.10.4-0.20.00.4-0.2-0.3-0.2-0.60.20.1
Stereotopy head waving duration, day 70.10.10.3-0.5-0.20.2-0.3-0.4-0.5-0.50.0-0.1
Locomotion velocity, session 80.20.30.90.30.3-0.20.40.70.51.00.6-0.3
Locomotion distance, session 80.20.30.9-0.7-0.4-0.8-0.40.1-0.1-0.10.3-1.0
Degree of sensitization distance0.40.41.0-0.5-0.7-0.9-0.5-0.3-0.5-0.2-0.3-1.0
Degree of sensitization stereotypy0.00.00.3-0.20.10.50.1-0.2-0.10.00.20.1
Conditioned locomotion1.51.74.6-0.8-1.7-0.7-1.0-2.1-2.10.8-0.7-0.7
Cocaine response after cond. corrected0.91.11.7-1.2-1.1-1.1-1.0-1.1-1.0-0.9-1.3-0.4
Cocaine response after cond. not corrected0.20.20.5-0.4-0.5-0.4-0.3-0.6-0.5-0.1-0.50.7
Cocaine response before conditioning2.12.54.01.61.41.51.61.31.21.81.52.0
Saline control response1.52.02.9-1.6-1.4-1.6-1.6-0.9-1.3-1.6-0.7-1.7
Bone: connectivity density0.30.51.50.50.50.40.90.40.50.51.11.2
Bone: cortical apparent density0.60.82.30.60.90.71.00.81.00.7-0.51.5
Bone: cortical area0.30.42.7-0.7-0.2-0.60.1-0.00.01.6-0.7-0.2
Bone: cortical porosity0.30.40.90.60.60.50.50.50.7-0.51.00.4
Bone: cortical porosity0.10.10.50.20.30.30.40.10.3-0.70.60.3
Bone: cortical thickness0.20.41.70.00.3-0.10.60.50.51.3-0.60.8
Bone: cortical thickness0.20.31.1-0.6-0.3-0.6-0.2-0.1-0.1-1.0-0.6-0.2
Bone: cortical tissue density0.60.82.30.70.90.71.00.81.00.7-0.51.5
Condit. Reinf. active minus inactive responses4.14.55.5-2.2-2.3-2.1-2.3-2.4-2.2-1.2-2.0-2.4
Condit. Reinf. active-inactive response ratio0.80.81.2-0.7-1.0-1.1-1.1-1.0-0.7-0.5-0.8-1.1
Condit. Reinf. active responses6.68.19.7-3.0-3.1-2.7-3.0-3.1-3.1-1.9-2.6-2.9
Condit. Reinf. inactive responses3.74.56.8-2.3-2.3-1.7-2.1-2.4-2.6-1.8-1.9-1.7
Incentive salience index mean3.54.35.5-2.2-2.2-2.0-2.3-2.3-2.1-0.8-2.0-2.2
Condit. Reinf. lever presses1.52.12.8-1.5-1.6-1.5-1.7-1.6-1.5-0.5-1.4-1.6
Condit. Reinf. active minus inactive responses0.40.61.4-0.9-0.7-1.2-0.6-0.5-0.3-0.7-0.9-0.6
Condit. Reinf. active-inactive response ratio0.20.21.10.00.2-0.1-0.00.20.5-1.1-0.40.5
Condit. Reinf. active responses0.10.20.8-0.6-0.3-0.9-0.3-0.00.1-0.1-0.2-0.5
Condit. Reinf. inactive responses0.30.41.70.40.40.10.60.50.61.30.8-0.1
Condit. Reinf. lever presses0.40.50.9-0.9-0.8-0.8-0.6-0.7-0.7-0.4-0.5-0.9
Condit. Reinf. lever reinforcers received0.20.31.2-0.7-0.5-1.1-0.4-0.2-0.1-0.2-0.4-0.7
Conditioned reinforcement - actives0.40.81.5-1.1-1.0-1.2-0.8-0.6-0.80.3-0.5-1.1
Conditioned reinforcement - inactives0.10.10.3-0.2-0.3-0.6-0.2-0.1-0.10.3-0.4-0.1
Conditioned locomotion0.81.01.6-1.1-1.1-1.0-1.3-1.2-1.0-0.2-0.4-1.0
Patch foraging indifference point 0 sec0.10.20.50.70.40.70.70.00.20.10.10.7
Patch foraging indifference point AUC0.10.20.40.60.50.70.40.20.3-0.1-0.50.5
Delay disc. indifference point, 0s delay0.30.31.6-0.7-0.2-0.3-0.4-0.5-0.1-0.2-1.3-0.6
Delay disc. indifference point, 16s delay0.30.30.80.40.60.80.60.30.40.0-0.40.9
Delay disc. indifference point, 2s delay1.71.93.8-1.7-0.9-0.5-1.5-1.3-1.0-1.5-1.9-1.3
Delay disc. indifference point, 24s delay1.61.83.01.41.51.21.61.71.60.41.21.2
Delay disc. indifference point, 4s delay2.22.45.2-1.6-1.3-1.1-1.4-1.5-1.2-1.0-2.3-2.0
Delay disc. indifference point, 8s delay0.40.42.4-0.30.00.6-0.2-0.3-0.4-0.8-1.5-0.4
Indifference point function ln k1.12.03.71.61.40.91.31.71.70.61.91.2
Indifference point function log k1.12.03.71.61.40.91.31.71.70.61.91.2
Patch foraging total patch changes 0 sec0.10.20.50.50.10.60.5-0.3-0.1-0.2-0.00.7
Patch foraging total patch changes 12 sec0.40.51.5-0.1-0.50.1-0.2-1.0-0.8-0.8-1.20.2
Patch foraging total patch changes 18 sec0.71.03.4-0.5-1.0-0.3-0.5-1.5-1.4-0.4-1.8-0.2
Patch foraging total patch changes 24 sec0.10.20.7-0.10.00.20.3-0.2-0.00.8-0.80.5
Patch foraging total patch changes 6 sec0.10.20.70.1-0.30.20.1-0.8-0.50.7-0.40.2
Patch foraging time to switch 0 sec0.71.52.7-1.6-1.3-1.5-1.2-1.0-1.10.1-0.4-1.6
Patch foraging water rate 0 sec0.20.41.31.20.40.70.30.10.3-0.5-0.20.8
Patch foraging water rate 12 sec0.20.30.80.60.50.90.50.20.10.8-0.20.9
Patch foraging water rate 18 sec1.01.52.81.51.31.10.91.21.40.41.71.3
Patch foraging water rate 24 sec0.71.02.71.60.71.20.80.30.50.80.31.6
Patch foraging water rate 6 sec0.20.40.90.70.50.70.40.30.4-0.0-0.81.0
Seeking ratio, delayed vs. immediate footshock1.01.21.7-1.2-1.2-0.9-1.1-1.2-1.3-1.0-0.9-0.8
Distance traveled before self-admin0.10.20.6-0.30.10.10.30.20.10.80.60.7
Distance traveled after self-admin0.20.20.90.10.40.70.50.10.10.50.10.9
Extensor digitorum longus weight0.10.31.6-0.2-0.3-0.10.1-0.6-0.31.3-0.50.5
Bone: elastic displacement2.12.45.6-1.2-1.5-1.3-1.4-1.5-1.4-1.8-2.4-1.1
Bone: elastic work1.21.63.7-1.3-1.2-1.1-1.1-1.3-1.2-1.0-1.9-0.9
Bone: endosteal estimation0.81.82.8-1.5-1.4-1.0-1.3-1.5-1.7-0.3-1.4-1.4
Bone: endosteal perimeter0.20.40.9-0.8-0.6-0.6-0.6-0.5-0.60.9-0.1-0.8
Epididymis fat weight0.72.44.8-1.7-1.3-2.1-1.7-0.7-0.6-2.2-0.6-1.9
Delta time in closed arm before/after self-admin1.11.01.71.31.21.30.81.01.10.41.10.6
Delta time in open arm before/after self-admin0.70.71.10.60.80.51.00.91.01.00.30.8
Diff in mean of infusions in LGA sessions0.20.20.6-0.8-0.5-0.7-0.1-0.3-0.40.0-0.5-0.5
Delay discount exponential model param0.30.41.70.50.0-0.30.30.30.20.81.30.6
Extinction: sum of active levers before priming0.60.61.40.80.61.10.70.20.20.80.81.2
Active lever presses in extinction session 60.60.61.10.60.70.40.80.90.70.70.91.0
Bone: final force0.71.14.90.90.70.61.00.80.72.20.80.6
Bone: final moment0.40.63.60.60.40.40.70.40.31.90.50.4
Food consumed during 24 hour testing period4.86.610.82.62.92.42.83.32.90.82.42.0
Glucose0.10.10.30.10.0-0.10.30.10.0-0.40.50.5
Heart weight0.00.10.30.2-0.20.10.0-0.3-0.3-0.2-0.00.6
Delay discount hyperbolic model param0.50.62.20.70.2-0.20.50.50.31.01.50.9
Intermittent access intake day 1-15 change0.20.52.10.60.20.10.50.10.31.51.00.5
Intermittent access intake escalation0.30.62.50.70.30.10.70.30.51.60.90.7
Intermittent access intake escalation 20.10.10.4-0.0-0.4-0.5-0.0-0.3-0.20.60.30.2
Intermitt. access day 1 inactive lever presses0.00.10.10.20.1-0.3-0.20.30.4-0.20.4-0.0
Intermitt. access day 15 inactive lever presses0.50.93.51.10.70.20.71.01.01.90.70.6
Intermitt. access escalation Index0.30.41.00.40.5-0.00.80.80.7-0.11.00.1
Intermittent access day 1 total infusions2.23.55.1-1.9-1.9-1.7-2.0-1.9-1.9-1.7-2.3-1.6
Intermittent access day 15 total infusions1.31.93.2-1.4-1.6-1.8-1.4-1.5-1.3-0.6-1.5-1.2
Intermittent access terminal intake (last 3 days)3.14.15.5-2.1-2.3-2.3-2.0-2.1-2.1-1.1-2.3-1.6
Intermittent access total infusions2.73.25.2-1.8-2.0-2.2-1.7-1.7-1.7-1.1-2.3-1.2
Intermittent access day 1 locomotion0.81.02.0-0.7-0.8-0.9-1.3-0.9-0.5-1.3-1.4-0.9
Intermittent access day 15 total locomotion0.30.51.0-0.4-0.6-0.5-1.0-0.9-0.4-0.90.1-0.9
Intermittent access total locomotion0.40.51.1-0.5-0.8-1.1-0.8-0.9-0.5-0.1-0.8-0.5
Intermittent access standard deviation0.40.91.6-0.7-0.9-0.8-1.1-1.1-0.8-0.7-0.9-1.3
Left kidney weight0.31.33.7-1.0-0.9-1.1-1.3-1.0-0.6-1.9-0.9-1.0
Right kidney weight0.00.10.3-0.0-0.0-0.5-0.10.00.4-0.6-0.3-0.4
Cocaine induced anxiety0.30.41.80.80.40.60.80.20.21.3-0.10.5
Post-drug Anxiety0.30.31.8-0.0-0.4-0.40.1-0.4-0.31.4-0.7-0.2
Baseline Anxiety1.51.72.8-1.7-1.4-1.6-1.5-1.2-1.1-1.0-1.1-1.3
Tail length0.20.81.20.90.90.70.90.90.91.01.10.2
Length with tail0.20.81.70.91.00.91.00.81.11.30.40.3
Length without tail0.00.10.20.00.30.20.10.10.30.4-0.50.0
Times rat made contact with spout1.92.23.41.61.71.71.71.81.5-0.10.71.7
Lifetime Intake3.34.16.1-2.0-2.3-2.3-2.0-2.1-2.0-1.1-2.5-1.5
Liver weight, left0.40.61.40.20.70.20.60.81.01.21.10.7
Liver weight, right0.00.10.40.2-0.10.20.1-0.2-0.30.2-0.70.2
Locomotor activity2.84.37.5-2.7-2.2-2.6-2.2-1.7-1.8-1.2-1.5-2.2
Locomotor testing distance1.93.37.1-2.3-2.0-2.7-1.9-1.6-1.5-0.5-0.6-2.0
Locomotor testing rearing2.14.37.3-2.7-2.2-2.7-2.3-1.8-1.7-1.5-0.9-2.2
Locomotion in novel chamber5.67.210.2-3.0-2.8-2.1-3.2-3.1-3.1-2.7-1.0-2.3
Locomotion in novel chamber post-restriction0.30.41.1-0.8-0.6-1.0-0.8-0.3-0.2-0.80.3-0.6
Fecal boli incidents, locomotor time 10.10.20.5-0.10.20.60.10.4-0.3-0.60.7-0.0
Change in fecal boli incidents, locomotor task0.10.10.80.2-0.1-0.50.0-0.10.30.20.90.1
Time >=10cm from walls, locomotor time 10.10.10.80.20.20.10.00.10.3-0.10.9-0.2
Bouts of movement, locomotor time 10.40.52.0-0.2-0.4-0.0-0.1-0.7-0.6-0.8-1.4-0.5
Total resting periods, locomotor time 10.50.62.4-0.3-0.6-0.1-0.2-0.9-0.9-0.7-1.6-0.6
Rest time, locomotor task time 10.10.10.20.0-0.00.40.3-0.2-0.30.5-0.30.5
Distance moved, locomotor task time 11.42.23.5-1.6-1.4-1.4-1.7-1.4-1.3-1.4-1.0-1.9
Vertical activity count, locomotor time 11.63.76.6-2.1-1.9-2.0-2.2-1.8-1.5-2.6-0.8-1.9
Time >=10cm from walls, locomotor time 22.74.04.81.92.22.12.21.92.11.82.11.9
Bouts of movement, locomotor time 20.40.62.20.50.50.90.80.10.30.8-1.50.9
Total resting periods, locomotor time 20.30.62.70.50.50.70.70.10.40.7-1.60.7
Rest time, locomotor task time 20.20.20.70.20.0-0.10.20.3-0.00.7-0.7-0.8
Distance moved, locomotor task time 20.10.10.3-0.4-0.3-0.5-0.2-0.4-0.2-0.10.3-0.2
Vertical activity count, locomotor time 20.91.32.1-1.3-1.3-1.1-1.1-1.3-1.3-1.4-0.2-0.1
Light reinforcement 10.61.52.2-1.0-1.5-1.5-1.3-1.5-1.30.0-1.1-1.2
Light reinforcement 20.60.91.5-1.2-1.1-1.0-1.0-1.0-1.01.0-0.0-0.7
Bone: marrow area0.81.62.7-1.4-1.4-0.9-1.3-1.5-1.7-0.3-1.4-1.4
Bone: maximum diameter0.71.22.2-1.5-1.0-1.0-0.9-1.0-0.90.8-1.3-1.3
Bone: maximum force0.40.62.70.80.50.60.80.50.41.60.70.7
Bone: maximum moment0.20.31.50.40.10.30.50.1-0.11.20.30.4
Mean time between licks in bursts0.92.34.3-1.8-1.6-1.9-1.2-1.5-1.30.6-2.1-1.2
Mean num. licks in bursts0.30.43.00.40.2-0.2-0.00.60.3-1.70.10.4
Cd content in liver0.20.30.50.70.50.70.40.30.40.60.60.0
Co content in liver1.41.62.7-1.5-1.4-1.0-1.1-1.6-1.40.2-1.3-1.4
Cu content in liver1.01.23.00.71.10.80.91.01.31.71.10.7
Fe content in liver6.37.68.6-2.6-2.9-2.6-2.8-2.9-2.9-2.9-2.5-2.7
K content in liver0.60.61.10.10.90.60.61.11.00.80.90.5
Mg content in liver0.70.71.80.41.00.60.51.31.1-0.60.90.3
Mn content in liver0.30.30.80.20.60.30.50.90.80.20.80.4
Na content in liver0.20.30.7-0.8-0.4-0.6-0.5-0.3-0.20.00.7-0.5
Rb content in liver0.30.31.00.80.51.00.40.10.1-0.9-0.00.5
Se content in liver0.40.51.5-0.8-0.6-1.2-0.8-0.0-0.2-0.30.5-0.9
Sr content in liver12.911.228.83.13.02.53.12.83.35.43.62.6
Zn content in liver0.30.31.2-0.20.4-0.3-0.11.10.8-0.30.7-0.5
Bone: minimum diameter1.12.03.6-1.9-1.4-1.5-1.2-1.3-1.30.4-1.7-1.4
Time in familiar zone, hab. session 12.82.74.12.01.81.81.71.41.71.80.91.6
Time in novel zone, hab. session 15.45.46.3-2.5-2.5-2.3-2.2-2.1-2.5-2.2-2.0-2.4
Total zone transitions, hab. session 15.47.612.9-3.6-2.7-3.1-2.8-2.3-2.1-2.8-2.3-2.9
Total locomotion distance, hab. session 15.78.010.3-3.2-2.9-3.1-3.0-2.7-2.4-2.6-2.5-3.1
Locomotion velocity, hab. session 14.36.18.1-2.8-2.5-2.7-2.6-2.5-2.1-2.2-2.1-2.6
Time in familiar zone, hab. session 22.72.84.72.21.92.01.81.41.71.31.21.3
Time in novel zone, hab. session 25.15.27.3-2.7-2.6-2.7-2.4-2.0-2.4-1.9-1.5-2.0
Total zone transitions, hab. session 20.20.30.8-0.9-0.5-0.9-0.4-0.2-0.2-0.3-0.0-0.5
Total locomotion distance, hab. session 20.91.21.7-1.3-1.1-1.3-1.1-1.0-0.9-1.1-0.6-1.2
Locomotion velocity, hab. session 21.21.62.3-1.5-1.3-1.5-1.3-1.1-1.0-1.2-0.9-1.4
Novel to familiar place preference ratio2.02.29.6-1.4-1.2-1.1-1.2-0.9-1.2-3.1-1.2-0.7
Novelty place preference2.02.210.2-1.2-1.1-1.0-1.1-0.8-1.2-3.2-1.1-0.7
Time in novel zone, NPP test2.22.411.0-1.3-1.2-1.1-1.2-0.9-1.3-3.3-1.2-0.8
Total zone transitions, NPP test2.13.05.1-2.3-2.0-2.1-1.6-1.6-1.8-0.5-1.6-1.6
Total locomotion distance, NPP test5.27.29.9-3.0-3.1-3.1-2.7-2.8-2.9-1.5-2.2-2.4
Locomotion velocity, NPP test5.37.410.5-3.1-3.1-3.2-2.7-2.8-2.9-1.3-2.4-2.5
Intraocular pressure1.82.64.61.81.81.11.51.92.11.31.41.3
Delta distance traveled before/after self-admin0.10.10.50.30.20.60.1-0.10.0-0.7-0.30.1
Delta ambulatory time before/after self-admin0.10.20.70.20.10.60.3-0.1-0.1-0.1-0.80.7
Parametrial fat weight0.71.73.2-1.8-1.3-1.3-1.2-1.3-1.3-0.3-1.4-1.2
Pavlov. Cond. lever latency0.00.00.10.10.10.30.30.2-0.10.0-0.20.1
Pavlov. Cond. magazine entry latency0.30.30.80.90.70.60.50.70.7-0.20.20.4
Pavlov. Cond. change in total contacts0.40.41.10.90.70.60.20.80.7-0.31.0-0.0
Pavlov. Cond. index score0.30.30.80.90.60.50.40.50.70.30.50.4
Pavlov. Cond. latency score0.30.40.70.80.60.50.40.50.70.40.70.4
Pavlov. Cond. lever contacts0.10.10.20.30.20.00.00.20.40.10.40.1
Pavlov. Cond. magazine entry number0.30.41.2-1.1-0.7-0.6-0.5-0.7-0.80.1-0.3-0.3
Pavlov. Cond. intertrial magazine entries4.45.27.7-2.7-2.5-1.8-2.3-2.8-2.8-1.1-2.2-1.9
Pavlov. Cond. lever-magazine prob. diff.0.20.20.60.80.50.50.30.50.50.20.40.4
Pavlov. Cond. response bias0.00.10.20.50.20.1-0.10.20.3-0.20.0-0.2
Pavlov. Cond. lever latency1.01.42.01.21.31.41.11.21.10.90.71.4
Pavlov. Cond. magazine entry latency0.10.10.4-0.6-0.3-0.5-0.1-0.1-0.2-0.50.2-0.1
Pavlov. Cond. change in total contacts0.40.72.2-0.7-0.5-1.3-0.8-0.10.2-1.00.3-1.5
Pavlov. Cond. index score0.91.22.5-1.3-1.2-1.6-1.0-0.9-0.9-0.8-0.4-1.3
Pavlov. Cond. latency score1.01.32.6-1.4-1.3-1.6-1.1-1.0-0.9-1.0-0.4-1.4
Pavlov. Cond. lever contacts0.81.01.6-1.0-1.1-1.2-1.0-1.1-0.9-0.7-0.8-1.2
Pavlov. Cond. magazine entry number1.31.63.71.51.31.91.20.80.81.50.41.4
Pavlov. Cond. intertrial magazine entries0.60.91.71.01.11.01.01.31.0-0.20.40.8
Pavlov. Cond. lever-magazine prob. diff.1.11.42.9-1.4-1.3-1.7-1.2-1.0-0.9-1.1-0.4-1.4
Pavlov. Cond. response bias0.50.71.6-0.9-1.0-1.3-0.7-0.7-0.7-0.7-0.4-1.0
Time in closed arm before self-admin1.11.42.2-1.3-1.1-1.2-1.2-1.0-0.9-0.6-1.5-1.5
Time in closed arm after self-admin0.50.51.1-0.6-0.4-0.4-0.8-0.6-0.4-0.6-1.1-1.0
Time in open arm before self-admin0.40.52.5-0.4-0.10.1-0.5-0.1-0.4-0.91.6-0.6
Time in open arm after self-admin0.40.51.60.50.60.30.60.80.70.61.20.7
Bone: periosteal estimation0.61.22.0-1.4-1.1-0.9-0.8-1.0-1.20.8-1.3-1.0
Bone: periosteal perimeter0.30.43.7-0.5-0.1-0.20.2-0.00.01.9-0.1-0.1
Bone: post-yield work0.10.10.5-0.2-0.5-0.4-0.2-0.3-0.70.40.1-0.3
Progressive ratio test 1 active lever presses1.11.32.5-1.0-1.2-1.2-1.0-1.3-1.1-0.6-1.6-0.9
Progressive ratio test 1 breakpoint1.31.62.9-1.2-1.4-1.3-1.1-1.4-1.2-0.7-1.7-1.0
Progressive ratio test 1 inactive lever presses1.01.42.8-0.9-1.4-1.7-1.2-1.1-1.1-0.7-1.4-0.8
Progressive ratio test 2 active lever presses0.81.01.8-1.1-1.1-0.7-0.9-1.3-1.20.0-1.1-0.4
Progressive ratio test 2 breakpoint0.70.81.6-1.1-1.0-0.7-0.8-1.3-1.20.1-1.1-0.3
Progressive ratio test 2 inactive lever presses0.50.81.2-1.0-1.0-1.1-0.9-0.9-0.80.0-1.0-0.6
Incentive Sensitization - Responses1.11.53.8-1.9-1.4-1.1-1.2-1.5-1.5-0.0-0.5-0.7
Incentive Sensitization - Breakpoint1.21.63.7-1.9-1.4-1.1-1.2-1.5-1.5-0.2-0.6-0.8
Sum of active levers in priming session hrs 5-60.10.10.30.30.20.40.5-0.00.00.5-0.30.4
Progressive ratio0.00.10.30.00.10.30.30.1-0.10.2-0.6-0.1
Food seeking constrained by brief footshock0.30.40.8-0.5-0.6-0.2-0.4-0.9-0.8-0.7-0.80.1
Seeking ratio, punishment vs. effort0.00.10.20.0-0.1-0.2-0.1-0.20.0-0.30.30.5
Retroperitoneal fat weight0.31.12.5-1.3-0.8-1.0-1.1-0.9-0.5-1.2-1.6-0.8
Reaction time number correct0.10.30.7-0.0-0.5-0.4-0.6-0.7-0.50.9-0.4-0.3
Reaction time mean minus median2.76.810.0-3.2-2.9-2.7-2.7-2.7-2.9-1.4-2.1-2.4
Reaction time mean minus median AUC1.64.06.4-2.5-2.3-2.4-2.0-1.9-2.1-0.5-1.5-2.1
Reaction time num false alarms0.60.83.5-0.8-1.1-1.9-0.7-0.5-0.60.2-0.3-0.7
Reaction time num false alarms AUC0.81.34.4-1.0-1.4-2.1-1.1-0.9-0.9-0.0-0.4-1.1
Reaction time trials correct on left0.10.30.7-0.0-0.5-0.4-0.6-0.7-0.50.9-0.4-0.3
Reaction time trials on left0.20.40.7-0.2-0.6-0.5-0.7-0.8-0.60.7-0.4-0.4
Reaction time mean0.50.81.5-1.2-1.0-1.1-0.8-0.8-1.0-0.6-0.4-0.5
Reaction time mean AUC0.40.71.5-1.2-0.9-0.9-0.8-0.7-1.0-0.6-0.3-0.5
Median of all reaction times0.00.00.1-0.2-0.1-0.20.10.1-0.1-0.20.30.3
Reaction time omissions3.95.78.0-2.8-2.4-2.0-2.5-2.5-2.6-2.3-1.8-2.5
Reaction time false alarm rate0.50.72.8-0.7-1.0-1.7-0.6-0.4-0.5-0.3-0.2-0.8
Reaction time premature initiation rate2.23.012.41.41.31.31.61.21.33.51.51.4
Reaction time premature initiations1.62.913.81.41.21.21.31.01.13.71.41.3
Std. dev. reaction times3.25.98.4-2.9-2.8-2.6-2.6-2.6-2.8-1.2-1.8-2.0
Reaction time trials completed0.20.40.7-0.2-0.6-0.5-0.7-0.8-0.60.7-0.4-0.4
Reaction time trials AUC0.20.30.6-0.1-0.6-0.5-0.7-0.8-0.50.8-0.4-0.3
Run reversals in cocaine runway, females0.10.10.4-0.3-0.3-0.5-0.3-0.2-0.2-0.20.2-0.6
Run reversals in cocaine runway, males0.20.20.6-0.8-0.4-0.6-0.6-0.3-0.3-0.40.4-0.3
Latency to leave start box in cocaine runway0.30.31.4-0.3-0.1-0.7-0.50.30.2-1.2-0.3-0.6
Latency to leave start box in cocaine runway, F0.91.12.9-0.9-0.7-1.3-1.0-0.3-0.4-1.7-1.1-1.2
Latency to leave start box in cocaine runway, M0.10.10.3-0.00.1-0.2-0.10.30.3-0.50.5-0.1
Std. dev. time between licks in bursts1.41.92.8-1.6-1.4-1.5-1.5-1.6-1.2-0.2-0.9-1.7
Total sessions with >9 infusions3.84.67.3-2.0-2.1-1.7-2.2-2.2-2.2-2.3-2.7-1.7
Short access day 1 total inactive lever presses0.71.01.7-0.8-0.9-0.5-1.2-0.9-1.2-1.1-1.3-0.6
Short access day 10 total inactive lever presses0.10.30.7-0.8-0.6-0.8-0.3-0.3-0.40.4-0.5-0.4
Short access day 1 total infusions3.34.46.5-2.0-2.1-1.5-2.2-2.1-2.3-2.1-2.6-1.8
Short access day 10 total infusions1.82.33.4-1.4-1.8-1.8-1.5-1.8-1.70.4-1.6-0.8
Short access total infusions3.03.86.0-1.9-2.2-1.8-2.0-2.3-2.2-1.0-2.4-1.4
Short access day 1 locomotion2.32.94.3-1.6-1.5-1.0-2.1-1.8-1.7-1.9-1.8-1.9
Short access day 10 total locomotion0.20.30.60.80.70.80.30.40.70.10.50.5
Short access total locomotion1.31.53.3-0.9-1.0-0.7-1.5-1.3-1.0-1.8-1.3-1.1
One hour access (0.3 mA shock)0.60.71.5-1.2-1.0-1.0-0.6-1.0-0.90.4-0.7-0.4
Compulsive drug intake0.60.71.30.61.11.10.91.00.9-0.20.10.8
One hour access (shock baseline)1.11.73.8-1.5-1.6-1.9-1.1-1.4-1.3-0.0-1.0-1.0
Social response proportion3.13.54.9-1.9-1.9-2.0-2.2-1.8-1.7-2.1-1.7-1.4
Social responses6.07.79.8-2.5-3.0-2.7-3.1-3.1-3.0-2.3-2.5-2.6
Social time3.95.37.5-1.9-2.5-1.9-2.3-2.6-2.7-2.1-2.4-2.1
Soleus weight1.44.26.4-2.3-2.2-1.5-1.9-2.3-2.5-1.3-2.2-1.8
Bone: stiffness2.84.59.52.31.92.32.21.51.53.11.82.1
Tibialis anterior weight0.10.41.40.50.50.60.70.30.40.5-0.21.2
Time to tail flick, vehicle, before self-admin0.50.51.3-0.5-0.8-0.7-1.2-0.8-0.80.2-0.3-0.8
Time to tail flick, vehicle, after self-admin2.43.14.61.81.91.91.61.71.81.71.32.1
Time to tail flick, test, before self-admin1.11.22.0-1.1-1.1-0.6-1.4-1.4-1.3-1.0-0.7-0.7
Time to tail flick, test, after self-admin4.54.77.0-2.2-2.2-1.6-2.7-2.6-2.3-1.8-2.0-2.0
Delta time to tail flick, vehicle, before/after SA1.91.83.11.31.41.31.51.21.41.30.81.8
Delta time to tail flick, test, before/after SA0.50.61.0-0.8-0.6-0.6-0.8-0.5-0.5-1.0-0.9-1.0
Tibia length0.10.31.50.20.1-0.20.40.30.31.2-0.60.7
Ambulatory time before self-admin0.10.10.4-0.5-0.0-0.20.20.10.00.30.60.2
Ambulatory time after self-admin0.40.51.50.10.60.80.80.50.30.80.41.2
Bone: tissue strength0.10.10.30.40.20.60.2-0.1-0.1-0.30.10.6
Total heroin consumption0.30.42.10.3-0.4-0.20.1-0.5-0.60.2-1.40.6
Bone: trabecular number0.60.92.30.90.50.61.10.20.51.01.51.5
Bone: trabecular spacing0.10.10.4-0.10.30.2-0.00.50.2-0.1-0.6-0.4
Bone: trabecular thickness0.70.92.10.50.90.50.90.91.10.41.41.2
Bone: trabecular tissue density0.60.91.40.91.01.00.90.71.01.2-0.21.2
Water consumed over 24 hours5.77.69.83.13.13.03.02.92.92.02.22.4
Number of responses in last shaping day1.61.83.3-1.2-1.1-0.3-1.7-1.6-1.4-1.2-1.8-1.0