Nrm

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	isoform ratio	XM_039098800.2	0.09	0.05	7.3e-10	0.05	0.08	0.07	0.06	1.7e-06	6.5e-09	7.8e-08	1.6e-07
2	Adipose	alternative TSS	NM_212508.2	0.08	0.05	7.1e-09	0.05	0.05	0.05	0.05	3.5e-06	1.3e-06	2.8e-06	1.3e-06
3	Adipose	isoform ratio	NM_212508.2	0.09	0.05	6.6e-10	0.05	0.08	0.07	0.07	1.4e-06	5.4e-09	6.4e-08	8.7e-08
4	Adipose	alternative TSS	XM_039098800.2	0.08	0.05	7.0e-09	0.05	0.05	0.05	0.05	3.4e-06	1.4e-06	2.7e-06	1.5e-06
5	Adipose	gene expression	Nrm	0.03	0.03	5.6e-04	0.02	0.02	0.02	0.02	3.4e-03	2.7e-03	1.5e-03	5.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	1.0	1.8	2.5	-1.6	0.9	1.5	-1.1	-1.5
Area under the delay curve	1.9	2.2	2.3	1.4	-1.5	-1.4	1.4	1.5
BMI with tail	1.4	4.9	6.3	1.9	-2.3	-2.0	2.5	2.2
BMI without tail	3.5	10.6	12.5	3.2	-3.4	-3.2	3.5	2.9
Body weight	6.8	29.8	34.1	5.8	-5.1	-5.8	5.3	5.2
Weight adjusted by age	2.4	3.6	5.1	2.1	-1.3	-2.0	1.7	2.3
Bone surface	0.1	0.1	0.3	0.5	-0.3	-0.5	0.2	-0.1
Bone volume	0.1	0.1	0.3	0.3	-0.5	-0.3	0.4	0.1
Breakpoint value in progressive ratio session	0.3	0.3	0.5	-0.6	0.5	0.6	-0.7	-0.3
Number of licking bursts	0.3	0.5	0.7	-0.4	0.8	0.5	-0.8	-0.8
Context. condit. distance diff. score	7.9	9.6	11.3	-2.7	3.3	2.8	-3.3	-3.4
Locomotion velocity, session 1	0.4	0.5	0.8	-0.5	0.9	0.6	-0.8	-0.6
Locomotion distance, session 1	0.2	0.2	0.5	-0.7	0.1	0.6	-0.3	-0.2
Locomotion velocity, session 2	0.0	0.0	0.1	-0.1	0.3	0.1	-0.2	0.1
Locomotion distance, session 2	0.2	0.3	0.5	-0.7	0.5	0.7	-0.6	-0.1
Locomotion velocity, session 3	0.1	0.1	0.3	0.1	-0.5	-0.1	0.4	0.1
Locomotion distance, session 3	1.4	1.6	2.0	-1.3	1.0	1.3	-1.1	-1.4
Stereotopy head waving bouts, day 3	1.3	1.6	2.2	1.5	-0.9	-1.4	1.0	1.4
Stereotopy head waving duration, day 3	1.1	1.3	1.7	1.3	-0.9	-1.3	0.9	1.3
Locomotion velocity, session 7	5.4	5.9	6.1	-2.5	2.4	2.5	-2.4	-2.4
Locomotion distance, session 7	4.1	5.2	5.9	-2.4	2.1	2.4	-2.1	-2.4
Stereotopy head waving bouts, day 7	3.3	3.7	4.2	2.0	-1.7	-2.0	1.8	2.1
Stereotopy head waving duration, day 7	3.2	3.9	4.6	2.1	-1.8	-2.0	1.8	2.1
Locomotion velocity, session 8	0.4	0.5	1.4	0.0	1.2	0.1	-1.0	-0.3
Locomotion distance, session 8	4.2	6.0	7.0	-2.2	2.7	2.3	-2.6	-2.5
Degree of sensitization distance	0.5	0.5	1.0	-0.5	1.0	0.6	-0.9	-0.7
Degree of sensitization stereotypy	1.5	1.6	1.7	1.3	-1.2	-1.3	1.2	1.3
Conditioned locomotion	0.7	0.8	1.3	0.9	-0.6	-0.9	0.7	1.1
Cocaine response after cond. corrected	0.6	0.7	0.8	-0.9	0.7	0.9	-0.8	-0.9
Cocaine response after cond. not corrected	0.0	0.0	0.1	0.3	0.1	-0.2	-0.0	0.0
Cocaine response before conditioning	4.3	5.2	7.1	2.7	-1.7	-2.6	2.0	2.3
Saline control response	2.1	2.7	4.0	1.4	-2.0	-1.5	1.9	1.4
Bone: connectivity density	2.6	4.0	4.7	-2.1	1.7	2.1	-1.9	-2.2
Bone: cortical apparent density	0.5	0.6	1.1	0.4	-0.9	-0.4	0.9	1.0
Bone: cortical area	1.8	2.8	3.2	1.8	-1.6	-1.8	1.6	1.7
Bone: cortical porosity	0.7	0.8	0.8	0.9	-0.9	-0.9	0.9	0.8
Bone: cortical porosity	0.5	0.5	0.8	0.9	-0.6	-0.8	0.7	0.6
Bone: cortical thickness	3.8	6.3	8.0	2.1	-2.8	-2.2	2.8	2.6
Bone: cortical thickness	1.1	1.3	2.0	0.7	-1.3	-0.8	1.4	1.2
Bone: cortical tissue density	0.3	0.5	0.9	0.3	-0.8	-0.3	0.8	0.9
Condit. Reinf. active minus inactive responses	0.8	0.9	1.1	-1.0	1.0	1.0	-1.0	-0.8
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	0.0	-0.2	-0.0	0.2	0.4
Condit. Reinf. active responses	1.4	1.8	2.0	-1.4	1.3	1.4	-1.3	-1.3
Condit. Reinf. inactive responses	2.1	2.6	3.2	-1.8	1.3	1.8	-1.4	-1.7
Incentive salience index mean	1.9	2.4	3.0	-1.4	1.7	1.4	-1.7	-1.4
Condit. Reinf. lever presses	3.6	5.1	6.6	-1.9	2.6	2.0	-2.5	-2.2
Condit. Reinf. active minus inactive responses	1.0	1.3	1.7	1.2	-0.9	-1.2	1.0	1.3
Condit. Reinf. active-inactive response ratio	2.1	2.5	3.3	1.8	-1.1	-1.7	1.3	1.8
Condit. Reinf. active responses	0.0	0.0	0.1	-0.2	0.3	0.2	-0.2	-0.1
Condit. Reinf. inactive responses	1.8	2.3	2.9	-1.6	1.3	1.6	-1.4	-1.7
Condit. Reinf. lever presses	0.8	1.1	1.2	-1.1	1.1	1.1	-1.1	-1.0
Condit. Reinf. lever reinforcers received	0.1	0.1	0.2	-0.3	0.4	0.3	-0.4	-0.3
Conditioned reinforcement - actives	1.0	1.8	2.4	1.2	-1.6	-1.3	1.5	1.1
Conditioned reinforcement - inactives	1.4	2.1	3.0	1.2	-1.7	-1.2	1.5	1.5
Conditioned locomotion	0.1	0.2	0.3	0.5	-0.1	-0.5	0.5	0.3
Patch foraging indifference point 0 sec	0.4	0.8	2.0	0.5	-1.4	-0.6	1.1	0.4
Patch foraging indifference point AUC	1.1	1.6	2.0	1.4	-1.1	-1.4	1.3	1.1
Delay disc. indifference point, 0s delay	0.4	0.4	0.6	0.8	-0.5	-0.7	0.5	0.7
Delay disc. indifference point, 16s delay	2.1	2.4	3.8	1.2	-1.9	-1.3	1.8	1.3
Delay disc. indifference point, 2s delay	2.0	2.2	2.4	1.5	-1.6	-1.5	1.3	1.6
Delay disc. indifference point, 24s delay	0.5	0.5	1.0	0.6	-1.0	-0.6	0.8	0.6
Delay disc. indifference point, 4s delay	3.2	3.4	4.1	1.9	-1.8	-1.9	1.6	2.0
Delay disc. indifference point, 8s delay	0.3	0.3	0.5	0.6	-0.5	-0.6	0.6	0.7
Indifference point function ln k	0.3	0.5	0.9	-0.6	0.9	0.6	-0.8	-0.5
Indifference point function log k	0.3	0.5	0.9	-0.6	0.9	0.6	-0.8	-0.5
Patch foraging total patch changes 0 sec	0.6	1.2	2.7	0.7	-1.6	-0.8	1.3	0.6
Patch foraging total patch changes 12 sec	1.0	1.2	2.2	0.8	-1.5	-0.9	1.4	0.8
Patch foraging total patch changes 18 sec	0.3	0.4	1.2	0.0	-1.1	-0.1	0.9	-0.2
Patch foraging total patch changes 24 sec	0.2	0.3	0.6	-0.7	-0.4	0.6	0.2	-0.6
Patch foraging total patch changes 6 sec	0.8	1.1	2.7	0.6	-1.6	-0.7	1.3	0.7
Patch foraging time to switch 0 sec	0.1	0.2	0.4	-0.6	0.2	0.6	-0.2	-0.3
Patch foraging water rate 0 sec	0.5	1.1	1.5	0.9	-1.0	-1.0	1.0	1.2
Patch foraging water rate 12 sec	0.0	0.1	0.2	-0.2	-0.4	0.1	0.2	0.4
Patch foraging water rate 18 sec	0.2	0.4	0.4	0.6	-0.7	-0.6	0.5	0.7
Patch foraging water rate 24 sec	1.7	2.4	2.8	1.6	-1.4	-1.6	1.6	1.7
Patch foraging water rate 6 sec	0.1	0.1	0.2	0.1	-0.4	-0.1	0.4	0.3
Seeking ratio, delayed vs. immediate footshock	0.5	0.6	1.0	0.8	-0.8	-0.8	0.6	1.0
Distance traveled before self-admin	0.1	0.1	0.1	0.4	0.3	-0.3	-0.1	0.1
Distance traveled after self-admin	1.0	1.2	1.8	1.3	-1.1	-1.3	0.9	0.7
Extensor digitorum longus weight	0.0	0.2	0.7	0.2	0.2	-0.1	-0.2	-0.8
Bone: elastic displacement	0.4	0.4	0.8	0.4	-0.9	-0.5	0.7	0.6
Bone: elastic work	2.6	3.4	3.9	1.8	-2.0	-1.8	1.9	1.8
Bone: endosteal estimation	0.9	2.0	4.4	2.1	-0.4	-1.9	0.7	1.1
Bone: endosteal perimeter	0.3	0.7	1.6	0.1	1.3	0.0	-1.1	-0.9
Epididymis fat weight	2.1	7.2	13.6	1.2	-3.7	-1.5	3.4	2.7
Delta time in closed arm before/after self-admin	0.4	0.4	0.5	0.6	-0.4	-0.6	0.7	0.7
Delta time in open arm before/after self-admin	0.3	0.3	0.5	0.5	-0.7	-0.5	0.4	0.7
Diff in mean of infusions in LGA sessions	4.2	5.1	6.2	-2.5	2.0	2.5	-2.2	-2.1
Delay discount exponential model param	2.0	2.2	2.4	-1.4	1.5	1.5	-1.5	-1.5
Extinction: sum of active levers before priming	0.5	0.5	0.7	-0.8	0.4	0.8	-0.8	-0.5
Active lever presses in extinction session 6	0.1	0.1	0.1	-0.4	-0.1	0.3	0.0	-0.4
Bone: final force	6.4	10.2	11.2	3.1	-3.3	-3.2	3.3	3.1
Bone: final moment	5.6	9.0	9.8	3.0	-3.1	-3.0	3.1	2.8
Food consumed during 24 hour testing period	0.4	0.6	0.9	1.0	-0.3	-0.9	0.5	0.9
Glucose	1.6	2.5	5.2	-0.9	2.3	1.0	-2.0	-1.2
Heart weight	2.0	3.2	3.7	1.9	-1.7	-1.9	1.9	1.4
Delay discount hyperbolic model param	2.1	2.4	2.6	-1.5	1.6	1.5	-1.5	-1.6
Intermittent access intake day 1-15 change	0.0	0.1	0.3	-0.2	0.5	0.2	-0.2	-0.3
Intermittent access intake escalation	0.0	0.0	0.1	0.2	0.0	-0.2	0.3	0.1
Intermittent access intake escalation 2	0.1	0.1	0.5	0.1	0.7	-0.1	-0.3	-0.3
Intermitt. access day 1 inactive lever presses	0.1	0.3	0.5	0.7	-0.4	-0.6	0.2	0.7
Intermitt. access day 15 inactive lever presses	0.8	1.6	1.9	1.4	-1.3	-1.4	1.2	1.1
Intermitt. access escalation Index	2.9	4.1	4.6	-2.1	1.9	2.1	-2.1	-2.0
Intermittent access day 1 total infusions	0.1	0.1	0.3	-0.4	-0.5	0.4	-0.0	-0.3
Intermittent access day 15 total infusions	0.1	0.1	0.4	0.1	-0.6	-0.1	0.4	0.1
Intermittent access terminal intake (last 3 days)	0.4	0.5	1.0	0.5	-1.0	-0.5	0.8	0.5
Intermittent access total infusions	0.2	0.2	0.7	0.3	-0.8	-0.3	0.6	0.2
Intermittent access day 1 locomotion	0.1	0.1	0.1	-0.3	0.1	0.3	-0.3	-0.4
Intermittent access day 15 total locomotion	0.8	1.5	2.1	1.5	-1.1	-1.4	1.2	0.9
Intermittent access total locomotion	1.0	1.2	1.6	1.2	-1.0	-1.2	1.1	0.8
Intermittent access standard deviation	1.6	3.3	4.2	1.8	-1.7	-1.8	2.0	1.8
Left kidney weight	4.8	22.4	25.2	5.0	-4.2	-5.0	4.8	4.6
Right kidney weight	5.3	24.2	27.2	5.2	-4.5	-5.2	4.9	4.8
Cocaine induced anxiety	0.6	0.8	1.3	-0.8	0.9	0.8	-1.1	-0.9
Post-drug Anxiety	0.7	0.7	0.9	-0.8	1.0	0.8	-0.9	-0.8
Baseline Anxiety	0.3	0.4	0.6	-0.8	0.6	0.7	-0.3	-0.5
Tail length	3.6	14.1	20.2	4.5	-3.1	-4.4	3.2	3.4
Length with tail	5.1	22.2	31.7	5.6	-3.9	-5.5	4.0	4.3
Length without tail	5.0	15.9	20.7	4.5	-3.3	-4.5	3.5	4.0
Times rat made contact with spout	0.8	0.9	1.5	-1.2	0.4	1.1	-0.6	-1.2
Lifetime Intake	0.5	0.6	1.2	0.6	-1.1	-0.7	0.8	0.5
Liver weight, left	0.2	0.3	0.9	0.9	0.2	-0.8	-0.1	0.4
Liver weight, right	1.5	2.6	4.7	2.2	-0.9	-2.0	1.1	1.4
Locomotor activity	0.3	0.5	1.2	1.1	0.3	-1.0	0.2	0.2
Locomotor testing distance	0.1	0.1	0.3	0.3	0.6	-0.2	-0.2	-0.4
Locomotor testing rearing	0.1	0.2	0.5	0.7	0.2	-0.7	0.2	0.4
Locomotion in novel chamber	0.7	0.9	1.1	1.1	-0.9	-1.1	1.0	0.6
Locomotion in novel chamber post-restriction	1.0	1.6	2.2	1.1	-1.4	-1.1	1.2	1.5
Fecal boli incidents, locomotor time 1	0.5	0.7	1.4	-0.9	0.1	0.9	-0.8	-1.2
Change in fecal boli incidents, locomotor task	0.8	0.8	1.2	1.0	-0.6	-1.0	0.8	1.1
Time >=10cm from walls, locomotor time 1	0.4	0.5	0.7	0.9	-0.5	-0.8	0.4	0.7
Bouts of movement, locomotor time 1	1.1	1.2	1.5	-1.0	1.2	1.0	-1.2	-1.1
Total resting periods, locomotor time 1	0.4	0.5	0.8	-0.6	0.6	0.6	-0.9	-0.8
Rest time, locomotor task time 1	0.1	0.1	0.2	0.4	0.0	-0.3	-0.1	0.3
Distance moved, locomotor task time 1	0.5	0.8	1.3	0.8	-1.2	-0.8	1.0	0.7
Vertical activity count, locomotor time 1	0.1	0.3	0.5	0.5	-0.4	-0.5	0.7	0.6
Time >=10cm from walls, locomotor time 2	0.0	0.1	0.2	0.2	0.4	-0.1	-0.2	0.3
Bouts of movement, locomotor time 2	0.2	0.3	0.7	0.6	0.4	-0.6	0.0	0.9
Total resting periods, locomotor time 2	0.2	0.3	0.7	0.4	0.8	-0.3	-0.3	0.7
Rest time, locomotor task time 2	0.7	0.9	2.3	-0.3	1.5	0.4	-1.2	-0.5
Distance moved, locomotor task time 2	1.3	1.6	2.8	0.8	-1.7	-0.9	1.4	1.2
Vertical activity count, locomotor time 2	0.0	0.1	0.2	0.0	-0.2	-0.1	0.4	0.3
Light reinforcement 1	0.1	0.1	0.3	0.2	-0.5	-0.2	0.5	0.3
Light reinforcement 2	0.6	0.9	1.6	1.0	-0.5	-1.0	0.7	1.3
Bone: marrow area	0.9	2.0	4.3	2.1	-0.4	-1.9	0.7	1.1
Bone: maximum diameter	0.1	0.2	0.6	0.8	0.2	-0.7	-0.0	-0.1
Bone: maximum force	4.9	8.8	8.9	2.9	-3.0	-3.0	3.0	2.9
Bone: maximum moment	4.3	7.6	7.9	2.8	-2.7	-2.8	2.8	2.7
Mean time between licks in bursts	0.3	0.6	1.6	-0.2	1.3	0.3	-1.1	-0.5
Mean num. licks in bursts	0.1	0.1	0.2	-0.2	-0.5	0.1	0.5	0.2
Cd content in liver	0.1	0.1	0.4	-0.4	-0.0	0.4	-0.1	0.6
Co content in liver	1.0	1.1	1.8	0.7	-1.3	-0.8	1.2	1.1
Cu content in liver	1.6	1.8	2.9	-1.7	0.7	1.6	-1.0	-1.5
Fe content in liver	0.8	1.0	1.3	0.7	-1.1	-0.8	1.1	1.1
K content in liver	0.2	0.2	0.8	-0.3	0.1	0.3	-0.1	-0.9
Mg content in liver	1.5	1.5	2.9	-1.0	1.2	1.0	-1.2	-1.7
Mn content in liver	3.1	3.5	4.9	-1.3	2.1	1.4	-2.1	-2.2
Na content in liver	0.4	0.5	0.9	0.4	-0.9	-0.5	0.9	0.4
Rb content in liver	1.3	1.6	2.6	-1.2	1.1	1.2	-1.1	-1.6
Se content in liver	0.6	0.7	1.3	-0.4	1.1	0.5	-1.1	-0.7
Sr content in liver	0.4	0.4	0.6	0.7	-0.5	-0.7	0.5	0.5
Zn content in liver	0.1	0.1	0.2	-0.2	0.4	0.2	-0.3	-0.5
Bone: minimum diameter	0.2	0.3	0.8	0.9	0.2	-0.8	-0.1	0.2
Time in familiar zone, hab. session 1	2.2	2.1	3.5	-1.9	1.0	1.8	-1.2	-1.1
Time in novel zone, hab. session 1	0.9	0.9	1.8	1.3	-0.6	-1.3	0.7	0.7
Total zone transitions, hab. session 1	0.7	1.0	1.3	-1.0	0.8	1.0	-0.9	-1.1
Total locomotion distance, hab. session 1	0.4	0.6	0.7	-0.8	0.5	0.8	-0.7	-0.8
Locomotion velocity, hab. session 1	0.1	0.2	0.3	-0.5	0.2	0.5	-0.3	-0.5
Time in familiar zone, hab. session 2	0.1	0.1	0.3	-0.5	0.1	0.5	-0.2	-0.2
Time in novel zone, hab. session 2	0.2	0.2	0.3	0.6	-0.4	-0.6	0.4	0.4
Total zone transitions, hab. session 2	0.0	0.0	0.1	-0.1	-0.2	0.1	0.1	0.3
Total locomotion distance, hab. session 2	0.8	1.1	1.5	-1.2	0.8	1.2	-1.0	-0.8
Locomotion velocity, hab. session 2	0.9	1.2	1.6	-1.3	0.9	1.3	-1.1	-0.9
Novel to familiar place preference ratio	0.1	0.1	0.1	0.1	-0.4	-0.1	0.3	-0.3
Novelty place preference	0.1	0.1	0.3	0.3	-0.5	-0.3	0.4	-0.0
Time in novel zone, NPP test	0.2	0.2	0.4	0.5	-0.6	-0.5	0.5	0.1
Total zone transitions, NPP test	1.1	1.6	1.8	-1.3	1.2	1.3	-1.3	-1.1
Total locomotion distance, NPP test	0.8	1.1	1.6	-1.3	0.8	1.2	-0.9	-1.0
Locomotion velocity, NPP test	1.6	2.2	2.9	-1.7	1.2	1.7	-1.3	-1.5
Intraocular pressure	0.9	1.3	1.5	-1.2	1.2	1.2	-1.0	-1.0
Delta distance traveled before/after self-admin	2.4	2.5	3.4	1.6	-1.8	-1.6	1.6	1.2
Delta ambulatory time before/after self-admin	1.4	1.7	1.9	1.4	-1.4	-1.4	1.3	1.2
Parametrial fat weight	1.0	2.4	2.9	1.7	-1.7	-1.7	1.7	0.9
Pavlov. Cond. lever latency	1.2	1.5	2.9	0.7	-1.7	-0.8	1.5	1.1
Pavlov. Cond. magazine entry latency	2.0	2.5	4.1	-1.2	2.0	1.3	-1.9	-1.4
Pavlov. Cond. change in total contacts	0.2	0.2	0.4	0.7	0.1	-0.6	0.1	0.3
Pavlov. Cond. index score	2.1	2.7	4.7	-1.1	2.2	1.2	-2.0	-1.4
Pavlov. Cond. latency score	1.5	1.8	3.6	-0.8	1.9	0.9	-1.7	-1.2
Pavlov. Cond. lever contacts	0.9	1.1	2.4	-0.5	1.5	0.6	-1.3	-0.9
Pavlov. Cond. magazine entry number	2.8	3.6	5.1	1.6	-2.3	-1.7	2.1	1.7
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.4	-0.7	-0.2	0.6	0.0	-0.3
Pavlov. Cond. lever-magazine prob. diff.	2.4	3.0	5.1	-1.3	2.3	1.4	-2.1	-1.5
Pavlov. Cond. response bias	2.7	3.4	5.4	-1.4	2.3	1.5	-2.2	-1.6
Pavlov. Cond. lever latency	0.3	0.3	0.6	0.7	-0.5	-0.7	0.6	0.3
Pavlov. Cond. magazine entry latency	0.3	0.3	0.5	0.7	-0.4	-0.7	0.5	0.5
Pavlov. Cond. change in total contacts	0.1	0.2	0.3	0.4	-0.5	-0.4	0.5	0.5
Pavlov. Cond. index score	0.0	0.0	0.0	0.0	0.1	-0.0	-0.1	0.2
Pavlov. Cond. latency score	0.0	0.1	0.1	0.2	-0.2	-0.2	0.2	0.4
Pavlov. Cond. lever contacts	0.1	0.1	0.2	-0.5	0.3	0.5	-0.3	-0.1
Pavlov. Cond. magazine entry number	0.3	0.4	0.5	-0.6	0.5	0.6	-0.5	-0.7
Pavlov. Cond. intertrial magazine entries	1.4	2.1	2.7	-1.2	1.5	1.3	-1.6	-1.4
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	-0.0	0.1	0.1	-0.1	0.1
Pavlov. Cond. response bias	0.1	0.2	0.3	-0.4	0.5	0.4	-0.5	-0.2
Time in closed arm before self-admin	0.1	0.1	0.3	-0.3	0.3	0.3	-0.3	-0.6
Time in closed arm after self-admin	0.6	0.6	1.2	0.8	-0.5	-0.8	1.1	0.7
Time in open arm before self-admin	0.4	0.5	0.8	-0.6	0.9	0.6	-0.7	-0.6
Time in open arm after self-admin	0.2	0.2	0.5	-0.4	0.3	0.4	-0.7	-0.2
Bone: periosteal estimation	1.6	3.4	5.5	2.3	-1.2	-2.2	1.4	1.7
Bone: periosteal perimeter	0.4	0.6	1.4	1.2	-0.3	-1.1	0.4	0.6
Bone: post-yield work	0.5	0.7	1.7	-0.3	1.3	0.4	-1.1	-0.8
Progressive ratio test 1 active lever presses	0.2	0.3	1.2	0.2	-1.1	-0.2	0.4	0.2
Progressive ratio test 1 breakpoint	0.3	0.4	1.3	0.2	-1.2	-0.2	0.5	0.3
Progressive ratio test 1 inactive lever presses	0.3	0.4	1.8	0.1	-1.3	-0.1	0.6	0.0
Progressive ratio test 2 active lever presses	0.1	0.1	0.2	-0.5	-0.1	0.4	-0.1	-0.3
Progressive ratio test 2 breakpoint	0.1	0.1	0.2	-0.4	-0.1	0.4	-0.1	-0.2
Progressive ratio test 2 inactive lever presses	0.4	0.6	1.3	0.7	-1.1	-0.7	0.7	0.4
Incentive Sensitization - Responses	0.5	0.6	0.8	-0.9	0.7	0.9	-0.8	-0.7
Incentive Sensitization - Breakpoint	0.5	0.7	0.9	-0.9	0.8	0.9	-0.8	-0.7
Sum of active levers in priming session hrs 5-6	0.4	0.4	0.6	-0.7	0.8	0.7	-0.7	0.0
Progressive ratio	5.9	9.3	11.6	2.9	-3.4	-2.9	3.0	3.0
Food seeking constrained by brief footshock	0.1	0.1	0.3	-0.2	-0.1	0.2	-0.2	-0.5
Seeking ratio, punishment vs. effort	5.3	7.6	8.7	-2.7	3.0	2.7	-2.7	-2.8
Retroperitoneal fat weight	0.4	1.9	2.2	1.4	-1.5	-1.4	1.5	1.1
Reaction time number correct	0.2	0.4	0.7	0.2	-0.8	-0.3	0.8	0.6
Reaction time mean minus median	0.3	0.7	1.7	-0.2	1.3	0.3	-1.3	-0.4
Reaction time mean minus median AUC	0.3	0.8	1.8	-0.4	1.3	0.5	-1.3	-0.4
Reaction time num false alarms	0.3	0.4	0.7	0.7	-0.4	-0.7	0.5	0.8
Reaction time num false alarms AUC	0.5	0.7	0.9	1.0	-0.6	-0.9	0.7	0.9
Reaction time trials correct on left	0.2	0.4	0.7	0.2	-0.8	-0.3	0.8	0.6
Reaction time trials on left	0.2	0.4	0.7	0.3	-0.8	-0.3	0.8	0.6
Reaction time mean	1.0	1.6	3.3	-0.6	1.8	0.7	-1.6	-1.1
Reaction time mean AUC	0.9	1.5	3.3	-0.6	1.8	0.7	-1.6	-0.9
Median of all reaction times	0.9	1.2	2.6	-0.5	1.6	0.6	-1.3	-1.0
Reaction time omissions	0.5	0.7	1.7	-0.3	1.3	0.4	-1.1	-0.4
Reaction time false alarm rate	0.2	0.2	0.5	0.7	-0.1	-0.6	0.2	0.5
Reaction time premature initiation rate	1.7	2.4	3.0	1.6	-1.7	-1.6	1.6	1.2
Reaction time premature initiations	1.9	3.5	4.9	1.7	-2.2	-1.7	2.0	1.5
Std. dev. reaction times	0.3	0.6	1.5	0.0	1.2	0.1	-1.1	-0.3
Reaction time trials completed	0.2	0.4	0.7	0.3	-0.8	-0.3	0.8	0.6
Reaction time trials AUC	0.1	0.3	0.6	0.2	-0.7	-0.3	0.7	0.5
Run reversals in cocaine runway, females	0.1	0.1	0.4	-0.0	-0.6	-0.0	0.4	0.0
Run reversals in cocaine runway, males	0.7	0.7	1.3	1.1	-0.4	-1.0	0.4	0.8
Latency to leave start box in cocaine runway	0.3	0.3	0.9	-0.3	0.9	0.3	-0.4	-0.6
Latency to leave start box in cocaine runway, F	1.0	1.1	2.5	-0.8	1.6	0.8	-0.8	-1.0
Latency to leave start box in cocaine runway, M	0.8	0.7	0.8	0.9	-0.7	-0.9	0.9	0.7
Std. dev. time between licks in bursts	0.2	0.3	0.8	0.2	0.9	-0.0	-0.7	-0.3
Total sessions with >9 infusions	0.6	0.7	1.4	0.7	-1.2	-0.7	0.9	0.6
Short access day 1 total inactive lever presses	1.9	2.5	3.4	1.8	-1.4	-1.8	1.3	1.5
Short access day 10 total inactive lever presses	0.1	0.2	0.4	-0.4	0.2	0.5	-0.5	-0.7
Short access day 1 total infusions	0.0	0.0	0.0	-0.0	-0.2	0.0	0.1	0.1
Short access day 10 total infusions	0.4	0.5	1.2	0.5	-1.1	-0.6	0.8	0.4
Short access total infusions	0.7	0.8	1.5	0.8	-1.2	-0.8	1.0	0.7
Short access day 1 locomotion	1.2	1.5	1.8	-1.3	0.8	1.3	-1.2	-1.3
Short access day 10 total locomotion	0.1	0.2	0.4	0.6	0.2	-0.6	0.3	0.4
Short access total locomotion	0.0	0.0	0.0	0.1	-0.1	-0.1	-0.0	-0.2
One hour access (0.3 mA shock)	1.4	1.6	2.0	-1.3	1.1	1.3	-1.2	-1.4
Compulsive drug intake	4.2	5.0	5.7	-2.1	2.2	2.2	-2.4	-2.2
One hour access (shock baseline)	0.4	0.6	0.8	0.7	-0.9	-0.7	0.9	0.6
Social response proportion	0.1	0.1	0.1	0.3	-0.3	-0.3	0.0	0.3
Social responses	0.3	0.4	0.5	0.6	-0.6	-0.6	0.5	0.7
Social time	0.2	0.3	0.8	0.2	0.9	-0.1	-0.7	-0.3
Soleus weight	0.1	0.4	0.7	0.9	0.4	-0.7	-0.4	-0.5
Bone: stiffness	1.0	1.6	2.0	1.1	-1.3	-1.2	1.3	1.4
Tibialis anterior weight	0.1	0.4	1.1	0.3	-1.0	-0.3	0.9	-0.1
Time to tail flick, vehicle, before self-admin	1.5	1.5	2.5	-1.0	1.2	1.1	-1.2	-1.6
Time to tail flick, vehicle, after self-admin	0.8	1.1	1.5	-0.8	1.2	0.8	-1.1	-1.2
Time to tail flick, test, before self-admin	0.1	0.1	0.4	-0.2	0.1	0.2	-0.2	-0.6
Time to tail flick, test, after self-admin	0.8	0.8	2.0	-0.7	1.4	0.7	-0.9	-0.6
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.1	-0.2	0.1	0.2	-0.1	-0.1
Delta time to tail flick, test, before/after SA	0.4	0.4	0.6	-0.7	0.8	0.7	-0.6	-0.2
Tibia length	1.7	4.8	7.3	2.7	-1.4	-2.6	1.7	2.2
Ambulatory time before self-admin	0.1	0.1	0.2	0.4	0.1	-0.4	0.2	0.4
Ambulatory time after self-admin	1.4	1.7	2.3	1.5	-1.3	-1.5	1.1	1.1
Bone: tissue strength	4.8	4.9	5.5	2.3	-2.3	-2.3	2.3	1.8
Total heroin consumption	0.0	0.0	0.2	0.2	-0.4	-0.1	-0.1	0.1
Bone: trabecular number	1.0	1.6	2.4	-1.5	0.7	1.5	-1.0	-1.4
Bone: trabecular spacing	3.3	4.4	5.8	2.4	-1.7	-2.4	1.9	2.0
Bone: trabecular thickness	0.9	1.2	1.8	-1.3	0.9	1.3	-1.0	-0.8
Bone: trabecular tissue density	1.9	2.7	4.3	1.6	-1.4	-1.6	1.5	2.1
Water consumed over 24 hours	0.0	0.0	0.1	0.1	0.0	-0.1	-0.0	-0.3
Number of responses in last shaping day	0.6	0.7	0.9	0.9	-0.8	-0.8	0.7	1.0