Hub : Genes

Nradd

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability Nradd 0.24 0.14 1.7e-08 0.06 0.06 0.06 0.06 9.9e-08 1.6e-07 9.6e-08 1.5e-07
2 BLA gene expression Nradd 0.24 0.18 2.2e-10 0.16 0.18 0.17 0.18 4.5e-09 8.3e-10 1.9e-09 9.7e-10
3 NAcc mRNA stability Nradd 0.05 0.04 8.4e-08 0.05 0.05 0.05 0.05 8.6e-08 6.1e-08 6.2e-08 8.6e-08
4 IL alternative TSS NM_139259.2 0.15 0.13 9.7e-03 0.01 0.02 0.01 0 1.7e-01 1.2e-01 2.1e-01 2.4e-01
5 NAcc gene expression Nradd 0.05 0.05 1.3e-06 0.04 0.04 0.04 0.04 8.0e-07 9.1e-07 8.8e-07 9.2e-07
6 Brain mRNA stability Nradd 0.06 0.05 6.1e-05 0.06 0.04 0.04 0.05 4.3e-06 5.0e-05 6.6e-05 1.7e-05
7 PL gene expression Nradd 0.47 0.2 1.2e-13 0.13 0.12 0.12 0.12 2.9e-14 1.4e-12 9.7e-13 1.7e-13
8 Adipose gene expression Nradd 0.52 0.18 0.0e+00 0.18 0.23 0.22 0.2 3.6e-19 6.0e-25 1.3e-23 2.2e-21

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.00.00.10.1-0.0-0.00.0-0.10.30.30.1
Area under the delay curve1.61.92.21.41.51.5-1.51.41.31.3-1.3
BMI with tail0.10.41.4-1.2-0.5-0.50.4-1.0-0.3-0.3-0.4
BMI without tail0.51.62.7-1.6-1.3-1.21.2-1.4-1.2-1.20.7
Body weight5.122.226.5-5.1-4.8-4.84.7-5.1-4.7-4.73.6
Weight adjusted by age0.00.00.2-0.0-0.0-0.00.0-0.0-0.4-0.40.0
Bone surface0.10.20.40.40.50.5-0.50.30.40.4-0.6
Bone volume0.00.10.10.30.20.2-0.20.10.20.2-0.4
Breakpoint value in progressive ratio session0.10.20.30.30.40.4-0.40.20.60.6-0.3
Number of licking bursts0.10.20.30.40.50.5-0.50.50.50.5-0.4
Context. condit. distance diff. score0.00.10.2-0.10.00.0-0.0-0.00.50.5-0.1
Locomotion velocity, session 10.10.10.30.40.30.3-0.30.10.50.5-0.5
Locomotion distance, session 10.70.91.6-0.9-1.0-1.00.9-1.3-0.9-0.90.3
Locomotion velocity, session 20.40.51.00.50.70.7-0.70.40.70.7-1.0
Locomotion distance, session 20.10.10.70.30.20.2-0.2-0.20.10.1-0.8
Locomotion velocity, session 30.10.10.2-0.4-0.3-0.30.3-0.5-0.0-0.0-0.1
Locomotion distance, session 31.01.11.70.81.01.0-1.00.71.31.3-1.3
Stereotopy head waving bouts, day 30.10.10.4-0.3-0.1-0.10.1-0.1-0.7-0.70.1
Stereotopy head waving duration, day 30.30.30.5-0.5-0.5-0.50.5-0.4-0.7-0.70.6
Locomotion velocity, session 70.20.30.5-0.3-0.6-0.60.7-0.7-0.2-0.20.5
Locomotion distance, session 70.60.81.50.90.70.7-0.70.61.21.2-0.9
Stereotopy head waving bouts, day 70.00.00.20.20.20.2-0.20.4-0.2-0.20.1
Stereotopy head waving duration, day 70.20.20.3-0.4-0.5-0.50.5-0.3-0.5-0.50.5
Locomotion velocity, session 80.20.20.7-0.6-0.5-0.50.5-0.8-0.2-0.2-0.1
Locomotion distance, session 80.10.20.7-0.4-0.4-0.40.4-0.80.20.2-0.4
Degree of sensitization distance1.41.41.9-1.0-1.2-1.21.3-1.1-1.2-1.21.4
Degree of sensitization stereotypy0.00.00.10.1-0.0-0.00.00.3-0.3-0.30.4
Conditioned locomotion3.23.74.62.12.02.0-1.92.11.81.8-1.6
Cocaine response after cond. corrected0.30.30.6-0.8-0.5-0.50.5-0.4-0.6-0.60.5
Cocaine response after cond. not corrected1.82.12.7-1.6-1.4-1.41.4-1.4-1.6-1.61.2
Cocaine response before conditioning1.01.21.8-1.1-1.1-1.11.1-1.3-1.1-1.10.7
Saline control response1.01.32.1-0.7-1.0-1.01.1-0.9-1.4-1.41.2
Bone: connectivity density0.50.71.40.90.70.7-0.70.81.21.2-0.4
Bone: cortical apparent density0.30.40.50.60.60.6-0.60.60.70.7-0.4
Bone: cortical area0.10.20.30.40.40.4-0.40.3-0.3-0.3-0.6
Bone: cortical porosity0.20.20.70.90.30.3-0.30.50.40.40.0
Bone: cortical porosity0.10.10.70.80.20.2-0.20.40.30.30.1
Bone: cortical thickness0.30.51.7-0.5-0.4-0.40.4-0.4-1.3-1.30.2
Bone: cortical thickness0.00.00.00.1-0.0-0.00.0-0.0-0.1-0.10.0
Bone: cortical tissue density0.30.40.50.60.50.6-0.50.60.70.7-0.4
Condit. Reinf. active minus inactive responses0.10.20.4-0.3-0.4-0.40.4-0.2-0.3-0.30.7
Condit. Reinf. active-inactive response ratio0.30.40.8-0.6-0.6-0.60.6-0.4-0.5-0.50.9
Condit. Reinf. active responses0.00.00.1-0.00.10.1-0.10.30.30.30.2
Condit. Reinf. inactive responses0.60.70.90.70.90.9-0.90.90.90.9-0.8
Incentive salience index mean0.00.10.10.20.20.2-0.20.20.30.3-0.1
Condit. Reinf. lever presses1.52.12.51.31.41.4-1.41.21.51.5-1.6
Condit. Reinf. active minus inactive responses1.92.53.6-1.6-1.5-1.51.5-1.6-1.9-1.91.1
Condit. Reinf. active-inactive response ratio1.82.12.9-1.6-1.3-1.31.3-1.3-1.7-1.71.0
Condit. Reinf. active responses1.62.23.2-1.5-1.4-1.41.4-1.5-1.8-1.81.2
Condit. Reinf. inactive responses0.10.10.20.40.30.3-0.30.20.40.4-0.2
Condit. Reinf. lever presses2.33.23.7-1.9-1.8-1.81.8-1.9-1.9-1.91.3
Condit. Reinf. lever reinforcers received2.02.83.9-1.7-1.6-1.61.6-1.7-2.0-2.01.3
Conditioned reinforcement - actives1.83.03.91.61.71.7-1.71.02.02.0-2.0
Conditioned reinforcement - inactives1.42.12.81.51.71.7-1.71.40.90.9-1.7
Conditioned locomotion0.40.50.70.80.70.7-0.70.40.70.7-0.8
Patch foraging indifference point 0 sec0.71.31.9-0.8-1.3-1.41.3-1.3-0.8-0.81.3
Patch foraging indifference point AUC0.00.00.1-0.2-0.1-0.10.1-0.2-0.3-0.30.1
Delay disc. indifference point, 0s delay0.00.00.1-0.20.00.0-0.0-0.2-0.2-0.2-0.1
Delay disc. indifference point, 16s delay1.01.11.21.01.11.1-1.11.11.11.1-1.0
Delay disc. indifference point, 2s delay0.20.30.40.50.60.6-0.60.50.40.4-0.5
Delay disc. indifference point, 24s delay1.01.11.41.01.11.1-1.01.11.21.2-0.9
Delay disc. indifference point, 4s delay1.71.82.11.31.41.5-1.41.41.21.2-1.3
Delay disc. indifference point, 8s delay1.92.22.41.51.51.6-1.51.51.51.5-1.4
Indifference point function ln k0.30.51.10.50.60.6-0.60.30.90.9-1.1
Indifference point function log k0.30.51.10.50.60.6-0.60.30.90.9-1.1
Patch foraging total patch changes 0 sec0.81.52.1-1.0-1.4-1.41.4-1.4-0.9-0.91.3
Patch foraging total patch changes 12 sec0.81.11.3-1.0-1.1-1.11.1-0.8-1.0-1.01.1
Patch foraging total patch changes 18 sec2.13.13.9-1.3-1.8-1.91.9-2.0-1.7-1.71.8
Patch foraging total patch changes 24 sec2.03.43.9-1.9-1.9-1.91.9-2.0-1.7-1.71.7
Patch foraging total patch changes 6 sec0.10.10.3-0.1-0.4-0.40.4-0.2-0.1-0.10.6
Patch foraging time to switch 0 sec0.10.30.50.50.60.6-0.60.70.50.5-0.3
Patch foraging water rate 0 sec0.20.50.7-0.6-0.6-0.60.6-0.8-0.9-0.90.3
Patch foraging water rate 12 sec0.20.50.7-0.9-0.7-0.70.7-0.7-0.8-0.80.3
Patch foraging water rate 18 sec0.10.20.5-0.7-0.3-0.30.3-0.4-0.7-0.7-0.2
Patch foraging water rate 24 sec0.91.21.7-1.1-1.0-1.01.0-1.0-1.3-1.31.0
Patch foraging water rate 6 sec0.60.91.3-0.9-0.8-0.80.8-1.0-1.2-1.20.5
Seeking ratio, delayed vs. immediate footshock1.41.82.51.51.61.6-1.61.30.50.5-1.5
Distance traveled before self-admin0.20.30.50.10.50.5-0.50.30.70.7-0.5
Distance traveled after self-admin0.10.10.20.20.40.4-0.40.40.20.2-0.5
Extensor digitorum longus weight0.20.71.10.50.80.8-0.80.61.01.0-0.9
Bone: elastic displacement0.10.10.1-0.3-0.2-0.20.2-0.2-0.3-0.30.3
Bone: elastic work0.40.60.8-0.9-0.7-0.70.7-0.8-0.9-0.90.3
Bone: endosteal estimation0.00.10.2-0.1-0.4-0.40.4-0.40.20.20.3
Bone: endosteal perimeter1.32.83.71.61.61.6-1.61.51.91.9-1.7
Epididymis fat weight0.41.21.8-1.3-1.1-1.11.1-1.1-1.0-1.01.2
Delta time in closed arm before/after self-admin0.40.40.60.60.60.6-0.60.50.80.8-0.6
Delta time in open arm before/after self-admin0.30.30.4-0.4-0.6-0.60.6-0.4-0.5-0.50.6
Diff in mean of infusions in LGA sessions0.00.00.1-0.3-0.0-0.00.0-0.1-0.2-0.20.0
Delay discount exponential model param1.92.12.4-1.4-1.5-1.61.5-1.5-1.3-1.31.3
Extinction: sum of active levers before priming0.00.00.00.20.10.1-0.1-0.20.20.2-0.2
Active lever presses in extinction session 60.10.10.4-0.1-0.3-0.30.3-0.60.10.10.2
Bone: final force1.11.72.1-1.4-1.3-1.31.3-1.4-1.4-1.40.9
Bone: final moment1.32.12.5-1.6-1.4-1.41.4-1.5-1.6-1.61.0
Food consumed during 24 hour testing period1.41.92.5-1.5-1.4-1.41.4-1.6-1.4-1.41.1
Glucose0.81.31.7-1.3-1.2-1.21.2-1.2-1.0-1.01.0
Heart weight1.72.64.3-2.1-1.6-1.61.6-1.7-1.4-1.41.2
Delay discount hyperbolic model param2.12.32.7-1.5-1.6-1.71.6-1.6-1.4-1.41.4
Intermittent access intake day 1-15 change0.71.31.61.21.11.1-1.10.91.31.3-1.2
Intermittent access intake escalation0.91.82.11.51.31.3-1.31.11.41.4-1.4
Intermittent access intake escalation 20.20.20.30.30.40.4-0.40.20.50.5-0.5
Intermitt. access day 1 inactive lever presses0.00.10.20.10.40.4-0.40.4-0.2-0.2-0.4
Intermitt. access day 15 inactive lever presses0.81.72.31.31.51.5-1.51.50.60.6-1.4
Intermitt. access escalation Index0.00.10.20.40.10.1-0.10.10.40.4-0.1
Intermittent access day 1 total infusions0.20.40.70.80.60.6-0.60.40.50.5-0.8
Intermittent access day 15 total infusions1.62.53.31.81.51.5-1.51.21.71.7-1.7
Intermittent access terminal intake (last 3 days)1.41.82.71.61.31.2-1.30.91.51.5-1.4
Intermittent access total infusions1.92.33.31.81.51.5-1.51.11.51.5-1.7
Intermittent access day 1 locomotion0.10.10.10.1-0.3-0.30.3-0.3-0.3-0.30.1
Intermittent access day 15 total locomotion0.40.71.21.10.70.6-0.70.51.11.1-0.9
Intermittent access total locomotion1.11.32.11.51.01.0-1.00.81.21.2-1.2
Intermittent access standard deviation0.00.00.10.1-0.0-0.00.0-0.0-0.4-0.4-0.1
Left kidney weight0.63.03.5-1.9-1.8-1.81.8-1.7-1.7-1.71.5
Right kidney weight0.31.21.7-1.1-1.1-1.11.1-1.3-1.0-1.00.8
Cocaine induced anxiety0.10.10.3-0.1-0.1-0.10.1-0.2-0.5-0.50.2
Post-drug Anxiety0.00.00.00.10.20.2-0.20.1-0.0-0.0-0.1
Baseline Anxiety0.10.10.10.30.30.3-0.30.30.40.4-0.3
Tail length5.119.921.5-4.2-4.5-4.54.5-4.3-4.6-4.64.5
Length with tail9.440.745.3-6.2-6.4-6.46.4-6.3-6.7-6.75.9
Length without tail7.524.326.8-5.0-5.0-5.05.0-5.2-5.1-5.14.2
Times rat made contact with spout0.40.40.7-0.8-0.7-0.70.7-0.6-0.5-0.50.8
Lifetime Intake2.12.63.71.91.61.5-1.61.21.61.6-1.7
Liver weight, left0.81.42.3-1.0-1.0-1.01.0-0.9-1.5-1.51.2
Liver weight, right1.83.25.2-1.3-1.7-1.71.7-1.6-2.3-2.31.6
Locomotor activity5.28.210.1-2.8-3.2-3.23.2-3.1-2.3-2.32.7
Locomotor testing distance4.37.710.3-2.7-3.1-3.13.1-3.2-2.3-2.32.5
Locomotor testing rearing0.10.20.4-0.1-0.5-0.60.5-0.6-0.0-0.00.3
Locomotion in novel chamber0.10.10.30.10.40.4-0.40.30.20.2-0.5
Locomotion in novel chamber post-restriction0.40.61.2-0.9-0.9-0.90.9-1.1-0.3-0.30.8
Fecal boli incidents, locomotor time 10.30.50.7-0.8-0.7-0.70.7-0.7-0.7-0.70.6
Change in fecal boli incidents, locomotor task0.00.00.0-0.00.00.0-0.0-0.0-0.1-0.1-0.0
Time >=10cm from walls, locomotor time 10.10.20.40.70.40.4-0.40.60.10.1-0.2
Bouts of movement, locomotor time 10.20.20.8-0.0-0.2-0.20.2-0.2-0.9-0.90.3
Total resting periods, locomotor time 10.20.20.70.0-0.2-0.20.2-0.3-0.8-0.80.2
Rest time, locomotor task time 10.30.30.60.50.80.8-0.80.40.10.1-0.6
Distance moved, locomotor task time 10.91.42.0-1.4-1.3-1.31.3-1.1-0.9-0.91.1
Vertical activity count, locomotor time 10.30.61.1-1.0-1.0-1.01.0-0.5-0.4-0.40.9
Time >=10cm from walls, locomotor time 21.11.71.9-1.4-1.3-1.31.3-1.2-1.4-1.41.2
Bouts of movement, locomotor time 20.00.00.20.0-0.1-0.10.1-0.40.20.2-0.2
Total resting periods, locomotor time 20.10.10.20.30.10.2-0.2-0.20.50.5-0.4
Rest time, locomotor task time 20.00.00.10.40.20.2-0.2-0.0-0.0-0.0-0.2
Distance moved, locomotor task time 20.91.01.7-1.3-1.0-1.01.0-0.7-0.9-0.91.0
Vertical activity count, locomotor time 20.00.00.1-0.2-0.2-0.20.20.10.20.20.2
Light reinforcement 10.30.81.4-1.2-1.0-1.01.0-0.9-0.6-0.60.9
Light reinforcement 20.10.20.30.20.40.4-0.40.50.50.5-0.5
Bone: marrow area0.00.10.2-0.1-0.4-0.40.4-0.50.10.10.3
Bone: maximum diameter0.30.61.00.80.90.9-0.90.80.50.5-1.0
Bone: maximum force0.71.31.5-1.1-1.1-1.11.1-1.2-1.2-1.20.8
Bone: maximum moment0.81.41.7-1.2-1.2-1.21.2-1.3-1.3-1.30.9
Mean time between licks in bursts0.71.72.31.31.41.4-1.41.21.01.0-1.5
Mean num. licks in bursts0.50.70.8-0.9-0.9-0.90.9-0.8-0.8-0.80.9
Cd content in liver0.10.10.20.40.30.3-0.30.30.50.5-0.4
Co content in liver1.01.11.41.21.21.2-1.21.10.80.8-1.0
Cu content in liver3.94.65.0-2.1-2.2-2.22.2-2.2-2.0-2.02.0
Fe content in liver1.21.42.1-1.1-1.2-1.21.2-1.0-1.2-1.21.5
K content in liver0.10.10.3-0.5-0.4-0.40.4-0.6-0.2-0.20.0
Mg content in liver1.01.12.60.81.01.0-1.00.51.01.0-1.6
Mn content in liver0.10.10.2-0.1-0.1-0.10.1-0.50.00.0-0.4
Na content in liver0.50.61.2-0.5-0.7-0.70.8-0.5-0.8-0.81.1
Rb content in liver1.11.32.6-0.4-0.9-0.90.9-0.7-1.6-1.61.4
Se content in liver0.00.00.2-0.5-0.1-0.10.1-0.1-0.0-0.00.1
Sr content in liver0.20.21.0-0.30.20.2-0.2-0.30.40.4-1.0
Zn content in liver2.12.33.0-1.4-1.5-1.51.5-1.7-1.6-1.61.1
Bone: minimum diameter0.40.71.31.00.90.9-0.90.80.40.4-1.1
Time in familiar zone, hab. session 11.01.01.51.21.11.1-1.11.20.70.7-0.7
Time in novel zone, hab. session 10.50.50.9-0.9-0.7-0.70.7-0.7-0.6-0.60.7
Total zone transitions, hab. session 10.40.61.1-1.0-0.9-0.90.8-1.0-0.2-0.20.3
Total locomotion distance, hab. session 10.20.30.6-0.8-0.6-0.60.6-0.6-0.4-0.40.4
Locomotion velocity, hab. session 10.20.30.5-0.7-0.6-0.60.6-0.6-0.3-0.30.4
Time in familiar zone, hab. session 20.40.40.70.80.70.7-0.70.6-0.0-0.0-0.9
Time in novel zone, hab. session 20.10.10.2-0.1-0.2-0.20.2-0.10.50.50.3
Total zone transitions, hab. session 20.10.20.3-0.5-0.2-0.20.2-0.50.50.5-0.4
Total locomotion distance, hab. session 20.20.30.6-0.8-0.6-0.60.6-0.6-0.2-0.20.3
Locomotion velocity, hab. session 20.10.20.5-0.7-0.5-0.50.4-0.5-0.0-0.00.3
Novel to familiar place preference ratio0.60.71.0-0.4-1.0-1.01.0-1.0-0.5-0.50.8
Novelty place preference0.60.60.9-0.3-0.9-0.90.9-1.0-0.5-0.50.8
Time in novel zone, NPP test0.80.91.2-0.5-1.1-1.11.1-1.1-0.7-0.71.0
Total zone transitions, NPP test1.92.74.7-1.9-1.8-1.81.7-2.2-1.2-1.20.8
Total locomotion distance, NPP test0.91.21.9-1.4-1.1-1.11.1-1.2-0.9-0.90.8
Locomotion velocity, NPP test0.91.21.9-1.4-1.2-1.21.2-1.3-0.8-0.80.8
Intraocular pressure0.81.22.4-1.1-1.2-1.21.3-1.0-0.5-0.51.6
Delta distance traveled before/after self-admin0.00.10.20.1-0.2-0.20.20.1-0.4-0.40.1
Delta ambulatory time before/after self-admin0.81.01.5-0.6-1.1-1.11.1-0.7-1.2-1.20.9
Parametrial fat weight0.71.62.6-1.6-1.3-1.31.3-1.0-1.1-1.11.2
Pavlov. Cond. lever latency4.05.05.8-2.0-2.4-2.42.4-2.2-2.1-2.12.4
Pavlov. Cond. magazine entry latency7.29.210.13.03.23.1-3.23.02.82.8-3.2
Pavlov. Cond. change in total contacts1.31.41.71.31.31.3-1.31.30.80.8-1.2
Pavlov. Cond. index score6.07.68.32.62.92.9-2.92.72.62.6-2.9
Pavlov. Cond. latency score5.87.48.22.62.82.8-2.82.72.62.6-2.9
Pavlov. Cond. lever contacts2.32.83.61.41.81.8-1.81.61.51.5-1.9
Pavlov. Cond. magazine entry number7.39.210.0-3.0-3.2-3.13.2-3.0-2.9-2.93.1
Pavlov. Cond. intertrial magazine entries0.40.50.6-0.7-0.8-0.80.8-0.7-0.6-0.60.8
Pavlov. Cond. lever-magazine prob. diff.5.46.67.42.42.72.7-2.72.52.42.4-2.7
Pavlov. Cond. response bias6.58.19.12.63.02.9-3.02.72.72.7-3.0
Pavlov. Cond. lever latency0.60.81.51.11.01.0-1.01.20.60.6-0.5
Pavlov. Cond. magazine entry latency0.20.30.60.10.30.3-0.40.10.70.7-0.8
Pavlov. Cond. change in total contacts2.33.84.5-2.1-2.0-2.02.0-2.1-1.9-1.91.4
Pavlov. Cond. index score0.20.30.6-0.8-0.5-0.50.5-0.8-0.2-0.20.0
Pavlov. Cond. latency score0.10.20.4-0.6-0.4-0.40.4-0.6-0.1-0.1-0.1
Pavlov. Cond. lever contacts0.81.11.8-1.2-1.2-1.21.2-1.3-0.8-0.80.7
Pavlov. Cond. magazine entry number0.30.30.8-0.2-0.4-0.40.4-0.2-0.8-0.80.9
Pavlov. Cond. intertrial magazine entries0.50.71.71.30.90.9-0.91.00.50.5-0.5
Pavlov. Cond. lever-magazine prob. diff.0.20.20.5-0.7-0.5-0.50.4-0.7-0.1-0.1-0.1
Pavlov. Cond. response bias0.10.10.3-0.6-0.4-0.40.4-0.60.10.1-0.2
Time in closed arm before self-admin0.91.22.3-1.2-1.1-1.11.1-1.5-0.8-0.80.9
Time in closed arm after self-admin0.10.20.20.00.40.4-0.40.00.50.5-0.5
Time in open arm before self-admin1.01.11.71.31.11.1-1.11.30.50.5-1.0
Time in open arm after self-admin0.30.31.21.10.40.4-0.40.60.50.5-0.4
Bone: periosteal estimation0.00.00.10.1-0.1-0.10.1-0.2-0.2-0.2-0.1
Bone: periosteal perimeter1.01.71.91.41.31.3-1.31.21.21.2-1.4
Bone: post-yield work0.10.10.4-0.1-0.1-0.10.1-0.20.70.7-0.1
Progressive ratio test 1 active lever presses0.10.10.30.60.00.0-0.0-0.40.40.4-0.2
Progressive ratio test 1 breakpoint0.10.10.30.60.10.1-0.1-0.30.40.4-0.3
Progressive ratio test 1 inactive lever presses0.30.40.60.70.70.7-0.70.30.40.4-0.8
Progressive ratio test 2 active lever presses2.12.43.01.71.61.6-1.71.31.31.3-1.7
Progressive ratio test 2 breakpoint2.22.53.01.71.71.6-1.71.41.31.3-1.7
Progressive ratio test 2 inactive lever presses2.03.34.61.82.02.0-2.01.41.51.5-2.1
Incentive Sensitization - Responses1.82.53.21.51.81.8-1.81.71.11.1-1.8
Incentive Sensitization - Breakpoint2.02.53.21.51.81.8-1.81.71.11.1-1.8
Sum of active levers in priming session hrs 5-60.00.00.10.20.00.0-0.0-0.10.30.30.1
Progressive ratio2.33.74.2-1.9-1.9-1.91.9-2.1-2.0-2.01.7
Food seeking constrained by brief footshock0.91.11.51.01.21.2-1.21.10.60.6-1.2
Seeking ratio, punishment vs. effort4.15.96.82.42.62.5-2.62.62.12.1-2.4
Retroperitoneal fat weight1.56.48.0-2.8-2.6-2.62.6-2.2-2.4-2.42.5
Reaction time number correct0.20.40.91.00.70.7-0.70.60.30.3-0.6
Reaction time mean minus median0.00.10.1-0.2-0.3-0.30.3-0.3-0.4-0.40.1
Reaction time mean minus median AUC0.10.30.5-0.5-0.6-0.60.6-0.7-0.7-0.70.4
Reaction time num false alarms0.30.40.80.90.50.5-0.50.50.70.7-0.4
Reaction time num false alarms AUC0.10.20.50.70.30.3-0.20.40.40.4-0.1
Reaction time trials correct on left0.20.40.91.00.70.7-0.70.60.30.3-0.6
Reaction time trials on left0.20.51.01.00.70.7-0.70.70.30.3-0.7
Reaction time mean0.00.00.00.2-0.1-0.10.1-0.10.20.20.1
Reaction time mean AUC0.00.00.10.3-0.0-0.10.1-0.10.20.20.1
Median of all reaction times0.00.10.20.40.00.0-0.00.10.40.40.0
Reaction time omissions0.10.20.50.70.40.3-0.30.70.50.50.2
Reaction time false alarm rate0.00.10.10.30.10.1-0.10.20.40.40.1
Reaction time premature initiation rate2.02.73.2-1.8-1.7-1.71.7-1.3-1.5-1.51.8
Reaction time premature initiations0.81.41.5-1.2-1.2-1.21.2-0.8-1.2-1.21.2
Std. dev. reaction times0.10.10.2-0.1-0.4-0.40.4-0.5-0.2-0.20.4
Reaction time trials completed0.20.51.01.00.70.7-0.70.70.30.3-0.7
Reaction time trials AUC0.30.61.21.10.80.8-0.80.80.40.4-0.8
Run reversals in cocaine runway, females1.11.11.71.01.11.1-1.11.30.90.9-0.8
Run reversals in cocaine runway, males1.01.01.6-1.3-0.9-0.90.9-0.4-1.2-1.20.9
Latency to leave start box in cocaine runway0.30.30.7-0.8-0.5-0.50.5-0.1-0.7-0.70.5
Latency to leave start box in cocaine runway, F0.70.81.3-1.1-0.9-1.00.9-0.8-0.7-0.70.8
Latency to leave start box in cocaine runway, M0.70.61.40.60.90.9-0.91.20.10.1-0.7
Std. dev. time between licks in bursts3.54.86.12.22.22.2-2.22.02.02.0-2.5
Total sessions with >9 infusions0.50.50.80.60.80.8-0.80.80.50.5-0.9
Short access day 1 total inactive lever presses3.24.15.22.02.12.1-2.11.72.02.0-2.3
Short access day 10 total inactive lever presses0.20.51.8-0.6-0.3-0.30.3-0.2-1.3-1.30.3
Short access day 1 total infusions2.63.54.02.02.02.0-2.01.91.51.5-1.9
Short access day 10 total infusions2.12.73.82.01.71.7-1.71.51.51.5-1.8
Short access total infusions3.34.25.22.32.02.0-2.01.82.02.0-2.1
Short access day 1 locomotion0.50.70.80.50.90.9-0.90.90.70.7-0.9
Short access day 10 total locomotion0.00.00.10.2-0.2-0.20.2-0.3-0.3-0.30.1
Short access total locomotion0.10.10.20.30.30.2-0.30.20.40.4-0.3
One hour access (0.3 mA shock)0.60.71.81.30.80.8-0.80.40.60.6-1.0
Compulsive drug intake0.50.60.90.90.90.9-0.91.00.50.5-0.7
One hour access (shock baseline)0.40.60.91.00.70.7-0.70.30.80.8-1.0
Social response proportion0.20.20.5-0.4-0.5-0.50.5-0.2-0.5-0.50.7
Social responses0.20.20.4-0.4-0.6-0.60.6-0.5-0.3-0.30.5
Social time0.40.61.20.60.80.8-0.81.10.50.5-0.6
Soleus weight3.911.614.1-3.6-3.6-3.63.5-3.8-3.1-3.12.9
Bone: stiffness0.20.40.8-0.3-0.5-0.50.5-0.5-0.9-0.90.4
Tibialis anterior weight0.00.10.2-0.4-0.2-0.20.2-0.30.30.3-0.1
Time to tail flick, vehicle, before self-admin2.32.43.2-1.6-1.4-1.41.4-1.6-1.8-1.81.4
Time to tail flick, vehicle, after self-admin0.10.20.5-0.7-0.4-0.40.4-0.2-0.1-0.10.4
Time to tail flick, test, before self-admin0.10.10.30.30.10.1-0.10.50.50.50.0
Time to tail flick, test, after self-admin0.10.10.20.40.40.4-0.40.30.20.2-0.4
Delta time to tail flick, vehicle, before/after SA0.70.60.90.60.70.7-0.70.91.01.0-0.8
Delta time to tail flick, test, before/after SA0.10.10.20.40.40.4-0.4-0.10.20.2-0.5
Tibia length6.417.722.1-4.4-4.3-4.34.3-4.7-4.2-4.23.2
Ambulatory time before self-admin0.50.81.30.50.90.9-0.90.61.21.2-0.9
Ambulatory time after self-admin0.00.00.10.10.10.1-0.10.20.30.3-0.1
Bone: tissue strength3.63.74.4-1.9-1.9-1.91.9-1.9-2.1-2.11.6
Total heroin consumption1.72.02.4-1.2-1.5-1.51.5-1.4-1.3-1.31.4
Bone: trabecular number0.81.32.21.21.01.0-1.01.01.51.5-0.9
Bone: trabecular spacing2.02.74.6-1.6-1.4-1.41.4-1.4-2.1-2.11.4
Bone: trabecular thickness0.00.00.1-0.2-0.2-0.20.2-0.20.30.30.0
Bone: trabecular tissue density0.40.60.8-0.7-0.7-0.70.7-0.8-0.9-0.90.5
Water consumed over 24 hours0.10.10.2-0.5-0.1-0.10.1-0.2-0.5-0.50.0
Number of responses in last shaping day0.20.20.30.50.50.5-0.50.30.10.1-0.6