Hub : Genes

Nradd

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability Nradd 0.23 0.14 2.3e-08 0.06 0.06 0.06 0.06 9.1e-08 1.9e-07 2.6e-07 1.3e-07
2 NAcc mRNA stability Nradd 0.04 0.04 3.2e-05 0.03 0.04 0.03 0.03 4.0e-04 4.5e-05 1.3e-04 2.2e-04
3 BLA gene expression Nradd 0.21 0.17 3.2e-09 0.14 0.15 0.15 0.15 6.0e-08 1.3e-08 1.7e-08 2.7e-08
4 NAcc gene expression Nradd 0.04 0.04 8.7e-05 0.04 0.03 0.03 0.03 6.0e-05 2.2e-04 4.3e-04 1.4e-04
5 Brain mRNA stability Nradd 0.07 0.05 3.0e-07 0.08 0.07 0.08 0.07 4.4e-08 1.0e-06 1.5e-07 1.7e-07
6 PL gene expression Nradd 0.25 0.24 1.8e-12 0.1 0.1 0.09 0.1 1.9e-11 1.7e-11 1.7e-10 1.4e-11
7 pVTA gene expression Nradd 0.07 0.07 6.6e-03 0.04 0.04 0.04 0.04 6.0e-03 7.8e-03 1.1e-02 1.1e-02
8 IL alternative TSS NM_139259.2 0.15 0.13 8.4e-03 0.06 0.03 0.05 0.05 1.3e-02 5.3e-02 2.6e-02 2.2e-02
9 IL alternative TSS XM_006243921.3 0.15 0.13 8.3e-03 0.06 0.03 0.05 0.05 1.2e-02 5.7e-02 2.2e-02 2.1e-02
10 Adipose gene expression Nradd 0.51 0.18 0.0e+00 0.2 0.23 0.22 0.2 5.9e-22 1.9e-25 1.6e-24 5.0e-22

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density0.00.10.20.2-0.2-0.20.20.2-0.20.20.4-0.40.1
Area under the delay curve2.22.43.0-1.51.61.6-1.5-1.51.4-1.51.7-1.7-1.4
BMI with tail0.41.42.81.4-1.1-1.11.70.7-0.71.1-1.51.50.1
BMI without tail1.53.24.71.8-1.9-1.92.21.8-1.81.9-1.61.61.3
Body weight6.426.831.95.4-5.4-5.45.65.0-5.05.2-5.15.14.4
Weight adjusted by age0.20.20.60.5-0.5-0.50.60.5-0.50.80.0-0.00.4
Bone surface0.10.10.4-0.20.30.3-0.1-0.30.3-0.30.6-0.6-0.5
Bone volume0.00.10.3-0.00.10.10.0-0.10.1-0.10.5-0.5-0.3
Breakpoint value in progressive ratio session0.10.10.30.3-0.3-0.30.30.4-0.30.3-0.60.60.3
Number of licking bursts0.10.20.5-0.70.40.4-0.4-0.40.4-0.3-0.20.2-0.4
Context. condit. distance diff. score0.00.00.00.0-0.0-0.00.10.0-0.00.0-0.00.0-0.0
Locomotion velocity, session 10.10.10.2-0.20.30.3-0.1-0.30.3-0.30.4-0.4-0.4
Locomotion distance, session 10.70.91.81.2-1.0-1.01.30.8-0.80.9-0.70.70.4
Locomotion velocity, session 20.30.30.7-0.50.60.6-0.4-0.70.7-0.70.4-0.4-0.8
Locomotion distance, session 20.10.20.50.00.10.10.2-0.30.3-0.20.6-0.6-0.7
Locomotion velocity, session 30.10.10.40.4-0.3-0.30.50.2-0.20.20.6-0.6-0.1
Locomotion distance, session 31.31.42.4-1.01.11.0-0.8-1.21.2-1.01.6-1.6-1.4
Stereotopy head waving bouts, day 30.20.20.90.1-0.2-0.20.20.2-0.20.3-1.01.00.2
Stereotopy head waving duration, day 30.30.40.60.4-0.6-0.60.50.6-0.60.7-0.80.80.7
Locomotion velocity, session 70.30.30.40.2-0.5-0.60.60.6-0.60.60.5-0.50.4
Locomotion distance, session 70.91.22.8-1.20.90.8-0.7-0.90.9-0.71.7-1.7-1.0
Stereotopy head waving bouts, day 70.10.10.2-0.10.20.3-0.4-0.20.2-0.40.2-0.2-0.0
Stereotopy head waving duration, day 70.20.30.50.7-0.5-0.50.40.5-0.50.4-0.50.50.6
Locomotion velocity, session 80.20.20.70.7-0.5-0.50.80.3-0.30.4-0.00.0-0.1
Locomotion distance, session 80.20.20.80.7-0.5-0.50.90.3-0.30.40.4-0.4-0.1
Degree of sensitization distance1.31.31.80.9-1.2-1.21.01.2-1.21.2-1.01.01.3
Degree of sensitization stereotypy0.00.00.10.3-0.1-0.1-0.20.2-0.2-0.20.1-0.10.4
Conditioned locomotion3.03.54.1-1.91.91.9-2.0-1.71.8-1.92.0-2.0-1.5
Cocaine response after cond. corrected0.50.51.70.5-0.5-0.50.40.5-0.50.5-1.31.30.6
Cocaine response after cond. not corrected2.12.33.71.5-1.4-1.41.41.4-1.31.4-1.91.91.3
Cocaine response before conditioning0.91.12.01.4-1.2-1.21.41.0-1.01.1-0.50.50.8
Saline control response1.21.62.21.3-1.4-1.41.31.4-1.41.4-0.70.71.5
Bone: connectivity density0.30.51.6-0.50.50.5-0.6-0.40.4-0.51.3-1.3-0.3
Bone: cortical apparent density0.30.40.6-0.50.60.6-0.7-0.50.6-0.60.8-0.8-0.3
Bone: cortical area0.10.10.2-0.50.40.4-0.4-0.40.4-0.4-0.10.1-0.5
Bone: cortical porosity0.10.10.5-0.20.20.2-0.4-0.0-0.0-0.10.7-0.70.2
Bone: cortical porosity0.30.31.0-0.40.40.4-0.6-0.20.2-0.31.0-1.0-0.1
Bone: cortical thickness0.20.31.20.3-0.4-0.40.40.4-0.40.4-1.11.10.3
Bone: cortical thickness0.00.00.0-0.1-0.1-0.10.10.1-0.10.1-0.10.10.0
Bone: cortical tissue density0.30.40.6-0.50.60.6-0.7-0.60.6-0.60.8-0.8-0.3
Condit. Reinf. active minus inactive responses0.10.10.30.2-0.3-0.30.20.4-0.40.5-0.40.40.5
Condit. Reinf. active-inactive response ratio0.30.40.60.3-0.5-0.50.40.6-0.60.7-0.80.80.7
Condit. Reinf. active responses0.00.00.1-0.20.10.1-0.2-0.00.0-0.1-0.00.00.1
Condit. Reinf. inactive responses0.60.71.0-0.70.90.9-0.9-0.80.8-1.00.8-0.8-0.8
Incentive salience index mean0.00.10.1-0.30.20.2-0.2-0.30.3-0.10.2-0.2-0.2
Condit. Reinf. lever presses1.52.02.6-1.41.51.5-1.2-1.61.6-1.41.3-1.3-1.6
Condit. Reinf. active minus inactive responses2.12.63.11.7-1.6-1.71.81.5-1.41.6-1.71.71.3
Condit. Reinf. active-inactive response ratio1.71.82.61.3-1.3-1.31.41.3-1.21.2-1.61.61.1
Condit. Reinf. active responses1.82.52.91.7-1.6-1.61.61.4-1.41.6-1.61.61.4
Condit. Reinf. inactive responses0.00.00.10.00.10.1-0.1-0.20.20.00.2-0.2-0.1
Condit. Reinf. lever presses2.43.23.91.9-1.8-1.92.01.7-1.71.8-1.91.91.4
Condit. Reinf. lever reinforcers received2.02.83.21.8-1.7-1.71.81.5-1.51.7-1.71.71.4
Conditioned reinforcement - actives0.30.30.7-0.60.60.50.0-0.70.70.00.4-0.4-0.8
Conditioned reinforcement - inactives0.70.81.5-1.21.01.0-0.8-1.01.0-0.80.4-0.4-1.0
Conditioned locomotion0.30.40.7-0.60.70.7-0.3-0.80.8-0.30.7-0.7-0.8
Patch foraging indifference point 0 sec0.81.31.71.2-1.3-1.31.21.2-1.21.3-0.30.31.3
Patch foraging indifference point AUC0.00.10.10.2-0.3-0.30.30.2-0.20.1-0.20.20.3
Delay disc. indifference point, 0s delay0.00.00.1-0.20.20.20.1-0.30.20.00.1-0.1-0.3
Delay disc. indifference point, 16s delay1.31.32.4-1.01.11.1-1.1-1.00.9-1.11.5-1.5-1.0
Delay disc. indifference point, 2s delay0.30.40.7-0.60.60.6-0.4-0.60.5-0.40.9-0.9-0.5
Delay disc. indifference point, 24s delay1.11.12.1-0.90.90.9-1.0-0.90.8-0.91.5-1.5-0.8
Delay disc. indifference point, 4s delay2.22.32.4-1.61.61.6-1.5-1.51.4-1.51.5-1.5-1.4
Delay disc. indifference point, 8s delay2.22.22.8-1.51.51.5-1.5-1.41.3-1.41.7-1.7-1.3
Indifference point function ln k0.30.41.0-0.20.50.5-0.2-0.70.7-0.40.9-0.9-1.0
Indifference point function log k0.30.41.0-0.20.50.5-0.2-0.70.7-0.40.9-0.9-1.0
Patch foraging total patch changes 0 sec1.01.62.01.3-1.4-1.41.31.3-1.31.4-0.70.71.3
Patch foraging total patch changes 12 sec0.81.01.61.1-1.1-1.10.81.1-1.10.8-0.70.71.3
Patch foraging total patch changes 18 sec2.53.24.51.5-1.9-1.92.01.8-1.82.1-1.51.51.9
Patch foraging total patch changes 24 sec2.93.63.91.9-2.0-2.01.91.9-2.01.8-1.91.91.8
Patch foraging total patch changes 6 sec0.10.10.30.3-0.4-0.40.20.4-0.40.20.1-0.10.6
Patch foraging time to switch 0 sec0.10.10.4-0.50.40.5-0.6-0.30.2-0.5-0.00.0-0.2
Patch foraging water rate 0 sec0.10.20.50.6-0.5-0.50.70.3-0.20.7-0.40.40.2
Patch foraging water rate 12 sec0.30.40.80.5-0.7-0.70.80.5-0.40.7-0.90.90.3
Patch foraging water rate 18 sec0.00.00.10.1-0.1-0.10.20.0-0.00.0-0.40.4-0.3
Patch foraging water rate 24 sec0.71.01.31.1-1.0-1.01.00.9-0.81.1-1.11.11.0
Patch foraging water rate 6 sec0.30.40.70.8-0.7-0.70.80.5-0.60.7-0.40.40.3
Seeking ratio, delayed vs. immediate footshock2.02.43.5-1.91.81.8-1.5-1.71.7-1.30.8-0.8-1.7
Distance traveled before self-admin0.00.00.2-0.1-0.1-0.10.40.0-0.10.40.1-0.1-0.0
Distance traveled after self-admin0.20.20.4-0.60.50.5-0.4-0.50.5-0.30.6-0.6-0.5
Extensor digitorum longus weight0.10.60.7-0.80.80.8-0.7-0.90.9-0.80.4-0.4-0.8
Bone: elastic displacement0.10.10.40.3-0.2-0.20.20.2-0.20.3-0.70.70.2
Bone: elastic work0.50.71.10.9-0.8-0.81.00.7-0.70.8-1.01.00.4
Bone: endosteal estimation0.10.10.20.2-0.4-0.40.40.5-0.50.50.2-0.20.4
Bone: endosteal perimeter1.22.62.9-1.51.61.6-1.5-1.71.7-1.61.7-1.7-1.6
Epididymis fat weight0.51.12.80.9-0.8-0.80.80.9-0.90.7-1.71.70.8
Delta time in closed arm before/after self-admin0.10.10.2-0.40.40.4-0.3-0.30.3-0.3-0.00.0-0.4
Delta time in open arm before/after self-admin0.30.30.30.3-0.5-0.50.40.5-0.50.60.5-0.50.5
Diff in mean of infusions in LGA sessions0.10.10.6-0.00.10.1-0.2-0.00.0-0.1-0.80.8-0.0
Delay discount exponential model param2.62.73.11.7-1.7-1.71.61.6-1.51.6-1.81.81.5
Extinction: sum of active levers before priming0.00.00.2-0.0-0.1-0.10.40.1-0.10.50.0-0.00.1
Active lever presses in extinction session 60.40.40.80.5-0.5-0.60.90.5-0.50.80.7-0.70.5
Bone: final force0.91.42.21.3-1.2-1.21.21.1-1.11.0-1.51.51.0
Bone: final moment1.21.92.91.4-1.3-1.31.41.3-1.31.2-1.71.71.1
Food consumed during 24 hour testing period1.31.62.11.5-1.3-1.31.41.2-1.21.3-1.21.21.1
Glucose0.20.30.50.7-0.6-0.60.60.6-0.60.5-0.40.40.5
Heart weight2.73.96.32.1-1.9-1.91.71.7-1.71.7-2.52.51.7
Delay discount hyperbolic model param2.52.73.11.7-1.7-1.71.61.6-1.51.6-1.81.81.5
Intermittent access intake day 1-15 change0.40.40.7-0.80.70.7-0.5-0.80.8-0.40.4-0.4-0.8
Intermittent access intake escalation0.40.40.7-0.90.60.6-0.4-0.70.7-0.30.5-0.5-0.7
Intermittent access intake escalation 20.00.00.20.1-0.2-0.20.40.1-0.10.4-0.20.20.1
Intermitt. access day 1 inactive lever presses0.00.00.00.00.10.1-0.0-0.00.0-0.10.2-0.2-0.1
Intermitt. access day 15 inactive lever presses0.60.71.2-1.10.90.9-0.9-0.80.8-0.90.6-0.6-0.8
Intermitt. access escalation Index0.10.10.60.0-0.0-0.00.00.0-0.00.00.7-0.7-0.0
Intermittent access day 1 total infusions0.00.00.1-0.30.10.10.0-0.20.2-0.10.3-0.3-0.3
Intermittent access day 15 total infusions0.40.40.8-0.90.60.5-0.2-0.70.7-0.30.7-0.7-0.7
Intermittent access terminal intake (last 3 days)0.20.30.6-0.60.40.30.0-0.50.5-0.00.8-0.8-0.6
Intermittent access total infusions0.60.61.1-0.80.70.7-0.3-0.80.8-0.41.1-1.1-0.9
Intermittent access day 1 locomotion0.10.10.3-0.50.30.3-0.3-0.30.3-0.30.4-0.4-0.4
Intermittent access day 15 total locomotion0.80.92.0-0.90.80.7-0.6-0.80.8-0.61.4-1.4-0.8
Intermittent access total locomotion1.31.52.2-1.11.21.2-0.9-1.21.2-1.01.5-1.5-1.2
Intermittent access standard deviation0.30.30.50.3-0.5-0.50.60.4-0.40.7-0.70.70.3
Left kidney weight0.51.53.61.9-1.4-1.31.41.1-1.10.9-1.01.00.9
Right kidney weight0.10.31.21.1-0.6-0.60.70.4-0.40.30.2-0.20.4
Cocaine induced anxiety0.40.50.7-0.70.80.8-0.7-0.80.8-0.70.5-0.5-0.7
Post-drug Anxiety0.20.20.4-0.40.50.5-0.7-0.40.4-0.70.1-0.1-0.3
Baseline Anxiety0.20.20.4-0.60.40.4-0.5-0.30.3-0.50.6-0.6-0.4
Tail length6.419.522.64.3-4.7-4.74.54.8-4.74.4-3.73.74.5
Length with tail9.032.936.75.9-6.1-6.15.85.9-5.95.7-5.05.05.7
Length without tail6.414.116.74.1-3.8-3.83.93.6-3.63.7-3.73.73.5
Times rat made contact with spout0.50.60.90.9-0.7-0.70.60.7-0.70.6-0.90.90.8
Lifetime Intake0.40.50.8-0.70.60.6-0.3-0.70.7-0.40.9-0.9-0.8
Liver weight, left0.10.10.40.2-0.3-0.20.10.5-0.50.20.4-0.40.6
Liver weight, right1.11.92.61.6-1.4-1.41.41.6-1.61.3-1.01.01.4
Locomotor activity5.28.310.12.9-3.1-3.13.22.9-2.83.2-2.52.52.6
Locomotor testing distance4.98.210.82.7-3.1-3.13.32.9-2.93.3-2.22.22.5
Locomotor testing rearing0.20.41.00.0-0.6-0.70.80.6-0.61.0-0.40.40.4
Locomotion in novel chamber0.20.20.4-0.20.50.5-0.2-0.60.6-0.3-0.60.6-0.5
Locomotion in novel chamber post-restriction1.01.22.01.0-1.0-1.01.20.8-0.81.2-1.41.40.9
Fecal boli incidents, locomotor time 10.60.61.40.6-0.7-0.70.70.6-0.60.8-1.21.20.5
Change in fecal boli incidents, locomotor task0.10.10.40.1-0.1-0.10.20.2-0.20.1-0.60.60.2
Time >=10cm from walls, locomotor time 10.20.20.3-0.30.30.3-0.6-0.10.3-0.50.5-0.5-0.2
Bouts of movement, locomotor time 10.00.00.10.1-0.1-0.10.20.2-0.10.1-0.30.30.2
Total resting periods, locomotor time 10.10.10.20.1-0.1-0.10.30.2-0.10.1-0.40.40.1
Rest time, locomotor task time 10.40.40.9-1.00.80.8-0.4-0.70.9-0.50.1-0.1-0.7
Distance moved, locomotor task time 11.51.72.41.6-1.4-1.41.11.3-1.41.2-1.21.21.2
Vertical activity count, locomotor time 10.80.81.31.2-0.9-0.90.41.0-1.00.7-1.01.00.9
Time >=10cm from walls, locomotor time 21.51.51.81.2-1.3-1.31.21.3-1.31.2-1.11.11.2
Bouts of movement, locomotor time 20.00.00.2-0.2-0.1-0.10.50.1-0.00.2-0.10.1-0.1
Total resting periods, locomotor time 20.10.10.3-0.50.20.20.2-0.20.2-0.10.1-0.1-0.4
Rest time, locomotor task time 20.00.10.2-0.40.20.2-0.0-0.20.2-0.0-0.30.3-0.2
Distance moved, locomotor task time 20.91.02.01.4-1.1-1.00.81.1-1.10.9-0.60.61.1
Vertical activity count, locomotor time 20.10.10.20.5-0.3-0.2-0.10.4-0.30.10.1-0.10.3
Light reinforcement 10.61.01.21.0-1.1-1.10.91.0-1.10.8-0.90.91.0
Light reinforcement 20.20.30.8-0.10.30.3-0.4-0.40.4-0.70.9-0.9-0.4
Bone: marrow area0.10.20.20.2-0.5-0.50.50.5-0.50.50.1-0.10.4
Bone: maximum diameter0.40.70.9-0.80.90.9-0.8-0.91.0-0.90.4-0.4-0.9
Bone: maximum force0.71.21.21.1-1.1-1.11.11.1-1.11.0-1.11.11.0
Bone: maximum moment0.81.41.41.2-1.2-1.21.21.2-1.21.1-1.21.21.1
Mean time between licks in bursts1.11.62.0-1.31.31.3-1.1-1.41.4-1.11.1-1.1-1.4
Mean num. licks in bursts0.50.61.51.2-0.8-0.80.80.8-0.80.7-0.20.20.8
Cd content in liver2.72.93.81.3-1.6-1.61.51.7-1.71.8-1.91.91.8
Co content in liver0.00.10.1-0.2-0.1-0.10.20.1-0.10.30.4-0.4-0.0
Cu content in liver4.04.95.22.2-2.2-2.22.22.2-2.22.3-2.22.22.1
Fe content in liver2.12.53.71.2-1.4-1.41.21.5-1.51.6-1.91.91.8
K content in liver0.70.71.11.0-0.8-0.81.00.8-0.80.7-0.90.90.5
Mg content in liver0.00.00.20.20.0-0.00.3-0.10.1-0.10.0-0.0-0.5
Mn content in liver0.50.61.31.0-0.8-0.91.10.7-0.70.80.1-0.10.4
Na content in liver0.40.40.90.6-0.6-0.60.40.7-0.70.6-0.30.30.9
Rb content in liver1.31.73.10.6-1.2-1.20.91.4-1.41.6-1.31.31.8
Se content in liver0.10.10.30.4-0.1-0.10.00.2-0.2-0.2-0.50.50.2
Sr content in liver0.10.10.20.3-0.0-0.00.3-0.10.1-0.10.1-0.1-0.5
Zn content in liver4.44.95.62.3-2.2-2.22.42.1-2.12.3-2.32.31.8
Bone: minimum diameter0.40.70.9-0.90.80.8-0.7-0.80.8-0.80.9-0.9-0.9
Time in familiar zone, hab. session 11.21.12.4-1.51.11.1-1.2-1.01.0-0.90.7-0.7-0.8
Time in novel zone, hab. session 10.60.51.21.1-0.8-0.70.70.8-0.80.6-0.60.60.7
Total zone transitions, hab. session 10.40.61.21.0-0.9-0.91.10.7-0.70.7-0.10.10.4
Total locomotion distance, hab. session 10.20.20.50.7-0.6-0.60.60.5-0.50.4-0.30.30.3
Locomotion velocity, hab. session 10.20.30.50.7-0.6-0.60.70.5-0.50.5-0.20.20.3
Time in familiar zone, hab. session 20.40.40.8-0.90.70.7-0.6-0.80.8-0.50.2-0.2-0.8
Time in novel zone, hab. session 20.00.00.10.2-0.2-0.20.10.2-0.20.20.3-0.30.3
Total zone transitions, hab. session 20.10.10.30.4-0.2-0.20.50.0-0.00.10.0-0.0-0.4
Total locomotion distance, hab. session 20.20.30.50.7-0.5-0.50.70.4-0.40.4-0.50.50.2
Locomotion velocity, hab. session 20.10.20.40.7-0.4-0.40.50.3-0.30.3-0.40.40.1
Novel to familiar place preference ratio0.60.70.90.9-0.9-0.90.90.9-0.90.90.2-0.20.8
Novelty place preference0.70.70.91.0-0.9-0.90.90.9-0.90.90.3-0.30.8
Time in novel zone, NPP test0.90.91.21.1-1.1-1.11.01.0-1.01.10.0-0.01.0
Total zone transitions, NPP test1.72.54.92.1-1.7-1.82.21.5-1.51.6-0.90.90.9
Total locomotion distance, NPP test0.91.21.91.4-1.1-1.11.31.0-1.01.0-1.11.10.7
Locomotion velocity, NPP test0.91.22.21.5-1.2-1.21.31.0-1.01.0-1.01.00.7
Intraocular pressure1.21.72.60.9-1.3-1.31.11.4-1.31.6-1.31.31.6
Delta distance traveled before/after self-admin0.30.30.5-0.40.40.4-0.7-0.50.5-0.70.6-0.6-0.4
Delta ambulatory time before/after self-admin0.10.10.30.4-0.5-0.50.10.5-0.50.2-0.10.10.4
Parametrial fat weight0.91.82.21.5-1.5-1.51.31.4-1.41.2-1.01.01.4
Pavlov. Cond. lever latency5.16.48.22.6-2.7-2.72.42.8-2.82.5-1.91.92.9
Pavlov. Cond. magazine entry latency6.28.09.3-3.03.03.0-2.7-3.03.0-2.82.2-2.2-3.0
Pavlov. Cond. change in total contacts1.51.62.2-1.51.41.4-1.3-1.41.4-1.20.7-0.7-1.3
Pavlov. Cond. index score6.17.79.3-3.03.03.0-2.7-3.03.0-2.82.0-2.0-3.0
Pavlov. Cond. latency score6.07.79.2-2.92.92.9-2.7-3.03.0-2.72.1-2.1-3.0
Pavlov. Cond. lever contacts2.93.54.7-1.82.02.0-1.7-2.12.1-1.81.3-1.3-2.2
Pavlov. Cond. magazine entry number7.08.810.23.2-3.1-3.12.93.2-3.22.9-2.32.33.1
Pavlov. Cond. intertrial magazine entries0.40.40.60.5-0.7-0.70.70.8-0.80.7-0.30.30.7
Pavlov. Cond. lever-magazine prob. diff.5.36.68.1-2.82.82.8-2.5-2.92.9-2.51.7-1.7-2.8
Pavlov. Cond. response bias6.68.09.6-3.03.03.0-2.8-3.13.1-2.82.0-2.0-3.1
Pavlov. Cond. lever latency0.40.50.9-0.90.70.8-1.0-0.60.6-0.80.7-0.7-0.3
Pavlov. Cond. magazine entry latency0.10.20.7-0.30.40.3-0.1-0.50.5-0.30.1-0.1-0.8
Pavlov. Cond. change in total contacts2.43.34.31.9-1.9-1.92.11.7-1.71.9-1.91.91.3
Pavlov. Cond. index score0.10.20.30.4-0.3-0.30.50.1-0.10.3-0.60.6-0.2
Pavlov. Cond. latency score0.10.10.20.4-0.2-0.20.50.1-0.10.2-0.50.5-0.3
Pavlov. Cond. lever contacts0.91.21.81.3-1.2-1.21.31.0-1.01.1-1.01.00.7
Pavlov. Cond. magazine entry number0.40.41.20.6-0.7-0.60.40.8-0.80.6-0.30.31.1
Pavlov. Cond. intertrial magazine entries0.40.50.9-0.90.70.7-0.8-0.60.6-0.50.9-0.9-0.3
Pavlov. Cond. lever-magazine prob. diff.0.10.10.30.4-0.2-0.30.50.1-0.10.2-0.50.5-0.3
Pavlov. Cond. response bias0.10.10.30.4-0.2-0.30.50.1-0.10.3-0.40.4-0.3
Time in closed arm before self-admin1.72.03.11.4-1.4-1.41.81.2-1.21.8-1.21.21.2
Time in closed arm after self-admin0.20.20.60.2-0.1-0.10.40.1-0.10.4-0.80.80.1
Time in open arm before self-admin1.11.21.8-1.01.21.2-1.4-0.90.9-1.30.9-0.9-1.0
Time in open arm after self-admin0.70.72.9-0.50.40.4-0.5-0.40.4-0.41.7-1.7-0.4
Bone: periosteal estimation0.00.00.0-0.0-0.1-0.10.20.1-0.10.10.0-0.00.0
Bone: periosteal perimeter1.22.02.1-1.41.41.4-1.4-1.51.5-1.41.3-1.3-1.4
Bone: post-yield work0.00.00.10.1-0.2-0.20.20.1-0.10.10.0-0.00.1
Progressive ratio test 1 active lever presses0.10.10.2-0.20.10.00.3-0.20.20.20.4-0.4-0.2
Progressive ratio test 1 breakpoint0.10.10.2-0.30.20.20.2-0.20.20.10.5-0.5-0.3
Progressive ratio test 1 inactive lever presses0.30.30.6-0.80.70.6-0.3-0.70.7-0.40.1-0.1-0.7
Progressive ratio test 2 active lever presses1.01.11.4-1.11.01.0-0.7-1.11.1-0.71.2-1.2-1.1
Progressive ratio test 2 breakpoint0.80.91.1-0.90.90.9-0.7-1.01.0-0.71.0-1.0-1.0
Progressive ratio test 2 inactive lever presses1.92.22.9-1.71.61.6-1.1-1.61.6-1.31.2-1.2-1.7
Incentive Sensitization - Responses1.71.71.9-1.31.41.4-1.4-1.41.4-1.31.2-1.2-1.3
Incentive Sensitization - Breakpoint1.61.71.8-1.31.31.3-1.3-1.41.4-1.31.2-1.2-1.3
Sum of active levers in priming session hrs 5-60.50.40.70.8-0.7-0.70.70.8-0.70.6-0.20.20.8
Progressive ratio3.74.35.22.1-2.0-2.02.32.0-2.02.2-2.12.11.8
Food seeking constrained by brief footshock0.91.11.6-0.71.01.0-0.9-1.01.1-1.01.3-1.3-1.0
Seeking ratio, punishment vs. effort5.77.07.7-2.62.62.6-2.7-2.72.7-2.82.6-2.6-2.5
Retroperitoneal fat weight0.51.62.11.5-1.4-1.41.11.4-1.41.0-1.01.01.4
Reaction time number correct0.40.50.7-0.90.60.7-0.6-0.80.8-0.40.9-0.9-0.6
Reaction time mean minus median0.00.00.20.4-0.2-0.20.20.1-0.10.1-0.30.30.0
Reaction time mean minus median AUC0.20.30.40.5-0.5-0.50.60.4-0.40.5-0.70.70.4
Reaction time num false alarms0.40.51.1-0.90.60.6-0.6-0.60.6-0.51.0-1.0-0.5
Reaction time num false alarms AUC0.20.20.9-0.50.20.3-0.4-0.20.2-0.20.9-0.9-0.0
Reaction time trials correct on left0.40.50.7-0.90.60.7-0.6-0.80.8-0.40.9-0.9-0.6
Reaction time trials on left0.40.60.8-0.90.70.7-0.7-0.80.8-0.50.9-0.9-0.6
Reaction time mean0.00.00.00.1-0.1-0.10.10.1-0.10.1-0.00.00.1
Reaction time mean AUC0.00.00.0-0.0-0.0-0.0-0.00.0-0.00.00.2-0.20.0
Median of all reaction times0.00.00.00.0-0.1-0.1-0.00.2-0.20.00.1-0.10.2
Reaction time omissions0.20.30.8-0.70.60.6-0.9-0.40.4-0.60.4-0.4-0.1
Reaction time false alarm rate0.00.10.2-0.30.10.1-0.3-0.10.1-0.20.5-0.50.0
Reaction time premature initiation rate1.72.32.91.6-1.7-1.71.31.6-1.61.1-1.51.51.7
Reaction time premature initiations0.71.01.51.0-1.2-1.20.81.0-1.00.7-0.80.81.2
Std. dev. reaction times0.10.10.20.3-0.4-0.40.40.2-0.20.4-0.10.10.3
Reaction time trials completed0.40.60.8-0.90.70.7-0.7-0.80.8-0.50.9-0.9-0.6
Reaction time trials AUC0.50.71.1-1.00.80.8-0.7-0.90.9-0.51.0-1.0-0.7
Run reversals in cocaine runway, females1.71.72.2-1.21.31.3-1.5-1.11.2-1.51.3-1.3-1.1
Run reversals in cocaine runway, males0.60.61.20.9-0.7-0.70.30.8-0.80.4-1.11.10.7
Latency to leave start box in cocaine runway0.60.61.60.7-0.6-0.60.30.6-0.80.4-1.31.30.6
Latency to leave start box in cocaine runway, F1.51.62.81.3-1.2-1.21.21.0-1.11.2-1.71.71.1
Latency to leave start box in cocaine runway, M0.30.20.6-0.50.60.6-0.8-0.20.2-0.70.1-0.1-0.4
Std. dev. time between licks in bursts3.64.35.8-2.42.22.2-1.9-2.32.3-1.91.5-1.5-2.4
Total sessions with >9 infusions0.10.10.3-0.40.20.2-0.2-0.30.30.0-0.60.6-0.4
Short access day 1 total inactive lever presses3.23.65.5-2.32.02.0-1.5-2.02.0-1.61.4-1.4-2.2
Short access day 10 total inactive lever presses0.10.10.2-0.10.10.1-0.20.0-0.0-0.3-0.50.5-0.1
Short access day 1 total infusions0.80.81.4-1.21.01.0-0.9-1.01.0-0.90.4-0.4-1.0
Short access day 10 total infusions0.10.10.2-0.30.20.20.1-0.30.30.10.5-0.5-0.4
Short access total infusions0.50.60.8-0.90.70.7-0.5-0.80.8-0.50.9-0.9-0.9
Short access day 1 locomotion0.00.00.1-0.20.20.2-0.1-0.30.3-0.1-0.10.1-0.3
Short access day 10 total locomotion0.00.00.10.2-0.2-0.20.30.1-0.10.3-0.10.10.1
Short access total locomotion0.00.00.0-0.10.10.10.1-0.20.20.10.0-0.0-0.2
One hour access (0.3 mA shock)0.30.41.4-0.60.40.3-0.0-0.50.5-0.11.2-1.2-0.6
Compulsive drug intake0.10.10.5-0.20.10.1-0.20.0-0.0-0.30.7-0.7-0.0
One hour access (shock baseline)0.10.20.3-0.40.20.20.2-0.40.40.20.6-0.6-0.5
Social response proportion0.40.51.00.9-0.7-0.70.40.8-0.80.5-0.30.31.0
Social responses0.30.40.60.8-0.7-0.70.70.6-0.60.6-0.20.20.6
Social time0.50.61.0-0.50.80.8-1.0-0.60.6-1.00.9-0.9-0.6
Soleus weight3.811.013.13.5-3.4-3.43.63.3-3.33.4-3.33.32.8
Bone: stiffness0.10.20.30.5-0.5-0.50.40.5-0.50.4-0.30.30.6
Tibialis anterior weight0.00.10.20.2-0.1-0.10.20.1-0.10.1-0.40.40.0
Time to tail flick, vehicle, before self-admin2.72.74.41.5-1.4-1.41.61.6-1.61.5-2.12.11.4
Time to tail flick, vehicle, after self-admin0.40.50.91.0-0.8-0.70.50.7-0.60.5-0.50.50.7
Time to tail flick, test, before self-admin0.10.10.20.5-0.2-0.1-0.30.3-0.3-0.20.4-0.40.4
Time to tail flick, test, after self-admin0.10.10.2-0.20.40.4-0.2-0.20.2-0.3-0.00.0-0.3
Delta time to tail flick, vehicle, before/after SA0.70.70.9-0.60.70.7-0.9-0.90.9-0.70.9-0.9-0.8
Delta time to tail flick, test, before/after SA0.20.20.4-0.60.50.5-0.0-0.60.6-0.30.0-0.0-0.6
Tibia length6.217.422.54.7-4.4-4.44.74.1-4.14.1-3.83.83.5
Ambulatory time before self-admin0.10.10.2-0.40.20.20.2-0.20.20.20.2-0.2-0.3
Ambulatory time after self-admin0.10.10.3-0.30.10.1-0.1-0.20.1-0.10.5-0.5-0.2
Bone: tissue strength3.23.13.51.7-1.8-1.81.81.7-1.71.8-1.91.91.6
Total heroin consumption1.11.31.61.1-1.2-1.21.11.2-1.11.0-1.21.21.1
Bone: trabecular number0.81.33.1-0.90.90.9-0.8-1.01.0-0.91.8-1.8-1.0
Bone: trabecular spacing1.72.23.81.3-1.3-1.31.21.4-1.41.2-1.91.91.4
Bone: trabecular thickness0.00.00.10.4-0.1-0.10.20.1-0.10.00.3-0.3-0.0
Bone: trabecular tissue density0.20.30.40.6-0.6-0.60.50.5-0.50.4-0.30.30.5
Water consumed over 24 hours0.00.00.20.20.10.1-0.0-0.20.2-0.1-0.40.4-0.2
Number of responses in last shaping day0.70.71.3-1.10.90.9-0.7-0.90.9-0.80.7-0.7-0.9