Hub : Genes

Nptx1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA mRNA stability Nptx1 0.09 0.06 3.0e-05 0.06 0.09 0.09 0.05 6.7e-04 1.5e-05 2.4e-05 1.1e-03
2 Brain gene expression Nptx1 0.18 0.09 1.1e-16 0.11 0.19 0.17 0.18 1.2e-10 2.7e-17 3.8e-16 1.1e-16
3 PL mRNA stability Nptx1 0.02 0.02 2.6e-03 0.01 0.01 0.01 0.01 1.4e-02 1.0e-02 2.1e-02 1.2e-02
4 IC gene expression Nptx1 0.09 0.06 5.2e-03 0.04 0.04 0.04 0.03 6.8e-03 1.1e-02 1.2e-02 2.8e-02
5 NAcc gene expression Nptx1 0.09 0.07 2.4e-08 0.05 0.04 0.05 0.04 3.6e-08 1.4e-06 1.5e-07 1.8e-07
6 Brain mRNA stability Nptx1 0.14 0.1 6.7e-09 0.08 0.09 0.08 0.08 6.7e-08 1.5e-08 4.6e-08 4.0e-08
7 Adipose gene expression Nptx1 0.1 0.06 1.2e-11 0.07 0.11 0.12 0.1 3.9e-08 5.2e-12 3.5e-13 1.7e-11
8 Liver gene expression Nptx1 0.07 0.04 1.6e-07 0.07 0.07 0.07 0.07 6.9e-08 7.6e-08 7.9e-08 6.4e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.10.10.2-0.3-0.3-0.5-0.4-0.4-0.20.2-0.4
Area under the delay curve0.80.91.41.1-0.61.11.21.00.5-1.1-0.7
BMI with tail0.72.54.2-1.80.3-2.0-1.9-2.0-2.00.6-0.5
BMI without tail2.26.711.0-3.31.8-3.0-2.8-2.9-2.92.10.8
Body weight2.19.213.8-3.73.4-2.7-2.4-2.7-3.13.52.3
Weight adjusted by age2.53.88.9-2.12.2-1.5-1.2-1.5-1.63.01.8
Bone surface0.20.30.80.10.60.40.50.50.50.70.9
Bone volume0.00.10.3-0.30.2-0.2-0.0-0.10.10.50.3
Breakpoint value in progressive ratio session0.60.71.2-1.00.2-1.1-1.0-1.1-0.90.5-0.2
Number of licking bursts0.10.10.2-0.40.4-0.3-0.4-0.4-0.40.20.3
Context. condit. distance diff. score2.02.44.4-1.4-0.4-1.8-2.0-2.1-1.90.3-1.3
Locomotion velocity, session 14.14.47.22.5-0.62.62.72.72.4-1.20.3
Locomotion distance, session 11.31.63.81.2-1.80.60.40.80.7-1.9-1.6
Locomotion velocity, session 24.45.27.92.8-1.82.52.62.32.7-2.1-0.7
Locomotion distance, session 20.30.51.40.3-1.2-0.3-0.3-0.20.1-0.9-1.1
Locomotion velocity, session 31.71.93.01.7-0.61.61.71.71.5-1.1-0.0
Locomotion distance, session 32.22.43.71.9-1.71.41.31.41.4-1.8-1.3
Stereotopy head waving bouts, day 30.40.51.00.8-0.20.90.91.00.8-0.60.1
Stereotopy head waving duration, day 30.20.20.40.6-0.40.50.40.60.5-0.6-0.2
Locomotion velocity, session 70.50.51.00.8-1.00.40.40.20.4-0.9-1.0
Locomotion distance, session 72.22.88.21.0-2.8-0.1-0.3-0.30.2-2.2-2.9
Stereotopy head waving bouts, day 70.30.40.7-0.80.7-0.6-0.5-0.5-0.80.50.3
Stereotopy head waving duration, day 70.40.51.3-0.71.2-0.3-0.3-0.2-0.60.90.9
Locomotion velocity, session 80.60.82.4-0.1-1.0-0.5-0.7-0.7-0.8-0.9-1.6
Locomotion distance, session 82.73.96.2-1.5-1.3-2.3-2.5-2.5-2.0-0.4-2.3
Degree of sensitization distance1.61.62.8-1.3-0.3-1.7-1.7-1.7-1.30.3-0.8
Degree of sensitization stereotypy0.70.81.5-1.10.5-1.0-1.1-1.0-1.20.6-0.0
Conditioned locomotion3.94.56.8-2.61.1-2.5-2.4-2.5-2.51.70.1
Cocaine response after cond. corrected0.10.10.20.3-0.30.20.10.10.2-0.4-0.2
Cocaine response after cond. not corrected0.50.60.91.0-0.60.80.80.70.8-0.8-0.3
Cocaine response before conditioning0.50.61.11.0-0.60.90.90.70.8-0.7-0.4
Saline control response1.52.03.5-1.71.7-1.2-1.1-1.1-1.31.91.0
Bone: connectivity density0.10.10.50.2-0.6-0.1-0.2-0.20.0-0.2-0.7
Bone: cortical apparent density1.82.44.01.8-1.91.21.11.11.4-2.0-1.6
Bone: cortical area3.55.411.5-2.53.4-1.4-1.0-1.1-1.93.12.9
Bone: cortical porosity1.11.13.10.11.40.71.01.00.71.11.8
Bone: cortical porosity0.91.03.0-0.41.60.30.50.50.21.41.7
Bone: cortical thickness2.94.811.1-2.33.3-1.2-0.9-0.9-1.62.92.9
Bone: cortical thickness1.01.12.1-1.21.4-0.8-0.8-0.6-1.21.21.0
Bone: cortical tissue density2.02.74.41.9-2.01.31.21.31.6-2.1-1.6
Condit. Reinf. active minus inactive responses1.82.03.2-1.81.2-1.5-1.6-1.4-1.61.30.6
Condit. Reinf. active-inactive response ratio1.21.32.0-1.40.6-1.4-1.4-1.3-1.40.7-0.0
Condit. Reinf. active responses2.83.55.5-2.31.8-1.9-1.8-1.8-2.02.01.0
Condit. Reinf. inactive responses0.50.71.1-1.00.9-0.8-0.6-0.7-0.71.00.6
Incentive salience index mean1.41.72.7-1.71.3-1.3-1.4-1.2-1.41.30.7
Condit. Reinf. lever presses0.20.30.5-0.60.0-0.7-0.7-0.6-0.60.0-0.3
Condit. Reinf. active minus inactive responses0.60.71.5-1.00.9-0.8-0.9-0.8-1.20.70.2
Condit. Reinf. active-inactive response ratio1.21.43.2-1.31.8-0.7-0.6-0.4-0.91.41.4
Condit. Reinf. active responses0.60.91.5-0.8-0.3-1.1-1.2-1.1-1.2-0.1-1.0
Condit. Reinf. inactive responses0.91.13.80.3-1.7-0.4-0.6-0.7-0.3-1.2-1.9
Condit. Reinf. lever presses1.72.44.1-1.4-0.7-1.9-2.0-1.9-1.7-0.1-1.5
Condit. Reinf. lever reinforcers received1.31.83.0-1.1-0.6-1.6-1.7-1.6-1.6-0.2-1.5
Conditioned reinforcement - actives0.10.10.2-0.1-0.4-0.3-0.3-0.50.10.4-0.3
Conditioned reinforcement - inactives0.50.71.2-1.10.8-0.8-0.6-0.8-0.81.10.6
Conditioned locomotion0.40.61.1-0.90.2-1.0-1.0-1.0-0.60.5-0.0
Patch foraging indifference point 0 sec0.40.71.5-1.0-0.2-1.2-1.1-0.9-0.70.1-0.5
Patch foraging indifference point AUC0.10.10.3-0.4-0.0-0.5-0.5-0.4-0.5-0.0-0.1
Delay disc. indifference point, 0s delay0.20.20.6-0.30.6-0.1-0.2-0.2-0.50.80.1
Delay disc. indifference point, 16s delay0.80.83.10.4-1.4-0.10.1-0.2-0.3-1.2-1.8
Delay disc. indifference point, 2s delay0.20.30.70.50.30.70.80.80.10.10.1
Delay disc. indifference point, 24s delay3.74.16.32.4-1.42.32.52.12.1-2.1-0.4
Delay disc. indifference point, 4s delay0.10.10.30.30.10.40.50.5-0.2-0.3-0.4
Delay disc. indifference point, 8s delay1.11.32.71.30.11.61.61.40.9-0.70.5
Indifference point function ln k0.50.82.20.9-1.50.30.30.10.7-1.0-1.3
Indifference point function log k0.50.82.20.9-1.50.30.30.10.7-1.0-1.3
Patch foraging total patch changes 0 sec0.61.12.4-1.2-0.4-1.5-1.4-1.2-1.0-0.0-0.8
Patch foraging total patch changes 12 sec0.10.20.5-0.60.0-0.7-0.5-0.1-0.30.10.0
Patch foraging total patch changes 18 sec1.01.52.5-0.9-1.0-1.5-1.4-1.2-1.3-0.6-1.6
Patch foraging total patch changes 24 sec1.11.93.0-1.71.0-1.6-1.6-1.6-1.61.00.3
Patch foraging total patch changes 6 sec0.30.41.0-0.80.8-0.6-0.4-0.2-0.20.71.0
Patch foraging time to switch 0 sec0.51.11.81.3-0.51.31.31.31.1-0.7-0.1
Patch foraging water rate 0 sec2.96.09.5-3.11.0-3.1-3.0-3.0-2.91.4-0.2
Patch foraging water rate 12 sec1.42.95.7-1.5-0.9-2.1-2.1-2.4-1.7-0.3-1.6
Patch foraging water rate 18 sec2.13.25.8-2.1-0.0-2.4-2.3-2.4-1.90.6-0.9
Patch foraging water rate 24 sec6.79.416.7-3.4-0.3-4.0-3.9-4.1-3.50.8-1.7
Patch foraging water rate 6 sec0.81.22.5-1.0-0.3-1.3-1.4-1.6-1.20.2-0.9
Seeking ratio, delayed vs. immediate footshock0.91.13.8-0.81.4-0.3-0.5-0.3-0.51.91.3
Distance traveled before self-admin0.91.11.7-1.21.2-0.9-0.9-0.9-1.21.30.8
Distance traveled after self-admin1.72.13.7-1.6-0.0-1.9-1.9-1.8-1.60.4-0.8
Extensor digitorum longus weight0.72.74.5-1.3-1.1-2.0-2.1-2.1-1.7-0.1-1.7
Bone: elastic displacement0.91.01.9-1.41.1-1.1-0.9-1.0-0.91.00.6
Bone: elastic work3.44.410.1-2.33.2-1.2-0.8-0.9-1.32.92.6
Bone: endosteal estimation0.10.20.5-0.2-0.5-0.4-0.4-0.6-0.4-0.1-0.7
Bone: endosteal perimeter0.51.02.7-0.51.60.10.30.2-0.31.61.6
Epididymis fat weight1.44.97.6-2.71.1-2.6-2.7-2.8-2.71.5-0.0
Delta time in closed arm before/after self-admin0.00.00.0-0.10.1-0.1-0.1-0.0-0.2-0.0-0.0
Delta time in open arm before/after self-admin0.20.20.5-0.60.0-0.7-0.4-0.6-0.60.2-0.1
Diff in mean of infusions in LGA sessions0.20.20.4-0.50.6-0.2-0.0-0.0-0.30.60.6
Delay discount exponential model param1.31.52.5-1.50.8-1.4-1.6-1.4-0.81.30.7
Extinction: sum of active levers before priming0.30.30.80.5-0.90.10.10.10.4-0.9-0.9
Active lever presses in extinction session 60.10.10.10.00.10.10.30.30.1-0.30.3
Bone: final force3.65.79.5-2.83.1-1.9-1.6-1.7-2.33.12.1
Bone: final moment4.06.510.9-3.03.3-2.0-1.7-1.8-2.43.32.3
Food consumed during 24 hour testing period1.01.42.7-1.40.5-1.5-1.6-1.3-1.50.1-0.1
Glucose7.211.416.74.1-1.64.04.04.14.0-2.60.1
Heart weight0.40.61.3-0.91.2-0.5-0.5-0.6-0.60.80.9
Delay discount hyperbolic model param1.21.32.3-1.40.6-1.3-1.5-1.3-0.71.20.6
Intermittent access intake day 1-15 change0.00.10.3-0.10.30.00.00.1-0.10.60.3
Intermittent access intake escalation0.00.00.2-0.00.20.10.00.10.00.50.3
Intermittent access intake escalation 20.30.31.0-0.20.80.10.1-0.0-0.01.00.8
Intermitt. access day 1 inactive lever presses1.03.97.0-2.61.1-2.5-2.1-2.0-2.51.10.2
Intermitt. access day 15 inactive lever presses1.22.54.0-1.80.4-1.9-2.0-2.0-1.91.0-0.5
Intermitt. access escalation Index0.60.81.1-1.10.7-0.9-1.0-1.0-1.00.90.3
Intermittent access day 1 total infusions0.10.10.3-0.3-0.1-0.4-0.4-0.5-0.10.3-0.0
Intermittent access day 15 total infusions0.20.31.0-0.60.5-0.5-0.4-0.4-0.31.00.5
Intermittent access terminal intake (last 3 days)0.40.61.9-0.70.7-0.5-0.4-0.7-0.31.40.7
Intermittent access total infusions0.20.20.7-0.50.2-0.5-0.4-0.5-0.20.80.3
Intermittent access day 1 locomotion0.10.10.2-0.40.1-0.4-0.3-0.4-0.10.10.1
Intermittent access day 15 total locomotion0.30.50.8-0.80.7-0.7-0.6-0.7-0.60.90.6
Intermittent access total locomotion0.20.30.4-0.70.3-0.6-0.5-0.6-0.40.50.3
Intermittent access standard deviation0.10.20.50.60.10.70.70.60.3-0.20.2
Left kidney weight0.10.51.4-0.01.20.50.70.50.10.71.2
Right kidney weight0.10.41.0-0.01.00.40.40.50.10.51.0
Cocaine induced anxiety1.01.44.4-0.91.9-0.1-0.00.1-0.41.52.1
Post-drug Anxiety0.20.20.6-0.00.50.30.70.70.1-0.10.8
Baseline Anxiety1.61.83.71.4-1.70.81.11.01.1-1.9-1.4
Tail length2.59.616.5-3.64.1-2.3-2.0-2.0-2.64.03.3
Length with tail1.67.118.3-2.34.3-0.7-0.5-0.5-1.43.93.9
Length without tail0.61.85.1-0.42.30.50.60.5-0.11.82.2
Times rat made contact with spout0.50.61.4-1.01.2-0.6-0.7-0.4-0.40.80.9
Lifetime Intake0.00.10.2-0.2-0.2-0.3-0.3-0.4-0.00.2-0.1
Liver weight, left0.71.22.21.2-0.01.41.51.51.4-0.20.5
Liver weight, right2.34.08.2-2.32.7-1.4-1.2-1.2-1.72.92.0
Locomotor activity0.30.50.90.8-1.00.40.20.40.6-0.9-0.8
Locomotor testing distance0.40.71.90.6-1.30.1-0.10.10.3-1.1-1.4
Locomotor testing rearing0.61.22.4-0.7-0.9-1.3-1.3-1.2-1.0-0.6-1.5
Locomotion in novel chamber0.20.20.5-0.50.0-0.6-0.5-0.7-0.50.0-0.2
Locomotion in novel chamber post-restriction0.60.92.0-1.01.3-0.6-0.4-0.5-0.31.31.4
Fecal boli incidents, locomotor time 10.10.20.50.6-0.70.40.00.20.7-0.4-0.2
Change in fecal boli incidents, locomotor task2.62.64.02.0-1.21.72.01.91.8-1.0-0.5
Time >=10cm from walls, locomotor time 10.70.81.7-0.5-0.6-0.9-1.0-1.0-1.0-0.3-1.3
Bouts of movement, locomotor time 11.41.63.01.5-1.41.11.01.11.3-1.7-0.7
Total resting periods, locomotor time 12.12.33.81.8-1.51.41.31.51.7-2.0-0.6
Rest time, locomotor task time 11.01.32.61.3-0.11.41.11.51.6-0.30.6
Distance moved, locomotor task time 10.50.71.4-1.10.7-1.0-0.5-0.9-1.20.80.3
Vertical activity count, locomotor time 10.71.73.3-1.40.4-1.5-1.5-1.8-1.60.7-0.7
Time >=10cm from walls, locomotor time 20.10.10.30.10.20.20.40.60.20.30.3
Bouts of movement, locomotor time 20.71.02.11.2-1.20.90.80.80.9-1.4-0.8
Total resting periods, locomotor time 20.30.61.30.8-0.90.50.50.50.5-1.1-0.7
Rest time, locomotor task time 20.20.20.40.5-0.10.60.50.60.6-0.50.1
Distance moved, locomotor task time 20.30.31.1-0.50.8-0.20.10.0-0.41.10.6
Vertical activity count, locomotor time 20.30.40.7-0.60.1-0.7-0.8-0.6-0.80.5-0.5
Light reinforcement 11.43.56.2-2.20.5-2.4-2.5-2.3-2.10.8-0.4
Light reinforcement 21.52.43.6-1.91.6-1.5-1.5-1.6-1.61.50.9
Bone: marrow area0.10.20.5-0.2-0.6-0.4-0.5-0.6-0.5-0.1-0.7
Bone: maximum diameter1.22.16.0-1.12.4-0.2-0.1-0.1-0.82.02.3
Bone: maximum force3.15.59.5-2.83.0-1.9-1.6-1.7-2.23.12.1
Bone: maximum moment3.56.110.5-3.03.1-2.0-1.6-1.7-2.23.22.3
Mean time between licks in bursts0.51.22.51.3-1.01.01.11.11.0-1.6-0.5
Mean num. licks in bursts0.10.10.2-0.40.2-0.4-0.4-0.2-0.10.20.0
Cd content in liver1.41.63.5-0.5-1.5-1.2-1.3-1.2-0.9-0.9-1.9
Co content in liver0.00.10.2-0.20.3-0.10.0-0.10.00.50.3
Cu content in liver0.40.51.2-0.51.1-0.1-0.0-0.1-0.11.11.1
Fe content in liver0.30.40.8-0.1-0.9-0.5-0.5-0.3-0.4-0.8-0.9
K content in liver1.61.62.3-1.50.9-1.4-1.4-1.5-1.41.20.3
Mg content in liver1.01.12.3-1.0-0.3-1.3-1.4-1.5-1.00.3-0.7
Mn content in liver0.10.10.2-0.20.5-0.0-0.1-0.1-0.20.50.2
Na content in liver0.00.00.2-0.20.0-0.2-0.3-0.4-0.20.1-0.1
Rb content in liver3.03.45.9-2.10.4-2.3-2.4-2.4-2.20.9-0.5
Se content in liver0.60.81.3-0.9-0.1-1.1-1.1-1.1-1.00.3-0.5
Sr content in liver0.80.71.30.80.01.01.11.11.1-0.10.5
Zn content in liver0.80.91.9-1.01.2-0.6-0.7-0.8-0.51.41.1
Bone: minimum diameter2.34.27.5-2.42.6-1.5-1.3-1.2-1.82.72.2
Time in familiar zone, hab. session 10.10.10.30.0-0.5-0.2-0.00.10.1-0.3-0.4
Time in novel zone, hab. session 10.00.00.1-0.10.3-0.0-0.2-0.3-0.30.2-0.0
Total zone transitions, hab. session 10.30.51.4-0.0-1.1-0.5-0.5-0.3-0.2-0.9-1.2
Total locomotion distance, hab. session 11.11.62.9-1.3-0.4-1.6-1.7-1.5-1.5-0.1-1.0
Locomotion velocity, hab. session 11.01.42.5-1.2-0.3-1.6-1.6-1.4-1.3-0.0-0.8
Time in familiar zone, hab. session 20.30.41.10.1-1.0-0.3-0.3-0.4-0.2-0.7-1.0
Time in novel zone, hab. session 20.10.10.20.30.20.50.40.50.30.00.2
Total zone transitions, hab. session 21.01.32.7-0.5-1.4-1.2-1.3-1.0-0.7-0.8-1.6
Total locomotion distance, hab. session 21.51.93.8-1.4-0.4-1.9-2.0-1.6-1.50.1-1.0
Locomotion velocity, hab. session 21.52.04.1-1.6-0.1-1.9-2.0-1.7-1.60.4-0.7
Novel to familiar place preference ratio1.31.42.5-1.60.9-1.4-1.2-1.1-1.21.30.6
Novelty place preference1.21.32.1-1.50.9-1.3-1.1-1.0-1.01.30.7
Time in novel zone, NPP test1.11.22.1-1.40.7-1.4-1.2-1.1-1.11.10.4
Total zone transitions, NPP test0.81.22.8-0.4-1.3-1.0-1.1-0.9-0.8-0.9-1.7
Total locomotion distance, NPP test1.82.54.6-1.3-1.1-2.0-2.2-1.8-1.5-0.3-1.6
Locomotion velocity, NPP test1.52.14.2-1.4-0.7-1.9-2.0-1.7-1.5-0.1-1.3
Intraocular pressure0.60.91.7-1.20.0-1.3-1.2-0.9-1.20.2-0.4
Delta distance traveled before/after self-admin0.70.71.9-0.3-1.0-0.9-0.8-0.8-0.5-0.7-1.4
Delta ambulatory time before/after self-admin0.81.03.00.4-1.6-0.3-0.3-0.20.1-1.3-1.7
Parametrial fat weight0.41.01.7-1.30.6-1.3-1.2-1.1-1.00.90.3
Pavlov. Cond. lever latency2.22.78.0-0.0-2.3-1.1-1.4-1.5-1.0-1.5-2.8
Pavlov. Cond. magazine entry latency1.51.95.7-1.12.4-0.10.00.1-0.51.72.2
Pavlov. Cond. change in total contacts0.20.20.8-0.00.70.30.40.40.40.40.9
Pavlov. Cond. index score2.22.87.9-1.32.8-0.30.00.1-0.52.22.7
Pavlov. Cond. latency score2.22.88.5-0.92.80.30.50.70.02.12.9
Pavlov. Cond. lever contacts1.11.34.4-0.31.80.40.70.80.51.32.1
Pavlov. Cond. magazine entry number1.51.95.90.8-2.4-0.2-0.4-0.50.1-1.7-2.4
Pavlov. Cond. intertrial magazine entries0.60.71.5-0.6-0.5-1.0-1.1-1.2-0.80.2-0.8
Pavlov. Cond. lever-magazine prob. diff.2.02.56.9-1.42.6-0.5-0.2-0.1-0.72.12.5
Pavlov. Cond. response bias1.51.85.8-0.62.30.30.50.60.11.62.4
Pavlov. Cond. lever latency2.53.45.82.00.02.42.42.42.2-0.60.9
Pavlov. Cond. magazine entry latency1.72.05.60.1-2.2-0.8-0.9-0.9-0.5-1.7-2.4
Pavlov. Cond. change in total contacts1.21.93.7-0.7-1.4-1.4-1.6-1.6-1.2-0.8-1.9
Pavlov. Cond. index score1.62.13.2-1.0-1.3-1.7-1.8-1.8-1.4-0.6-1.8
Pavlov. Cond. latency score1.62.23.2-1.0-1.2-1.7-1.8-1.8-1.5-0.6-1.7
Pavlov. Cond. lever contacts2.33.15.4-1.9-0.3-2.3-2.3-2.3-2.00.4-1.1
Pavlov. Cond. magazine entry number1.51.84.80.21.91.01.21.20.81.32.2
Pavlov. Cond. intertrial magazine entries1.01.52.2-1.51.4-1.1-1.1-1.1-1.31.40.8
Pavlov. Cond. lever-magazine prob. diff.1.51.93.6-0.7-1.4-1.5-1.6-1.6-1.2-0.8-1.9
Pavlov. Cond. response bias1.62.23.5-1.1-1.1-1.8-1.9-1.9-1.5-0.4-1.6
Time in closed arm before self-admin1.01.22.31.2-0.41.31.31.51.2-1.00.3
Time in closed arm after self-admin2.02.13.81.6-0.61.61.72.01.5-1.60.2
Time in open arm before self-admin0.20.20.6-0.20.4-0.1-0.3-0.5-0.20.80.2
Time in open arm after self-admin0.30.30.8-0.6-0.1-0.8-0.6-0.9-0.60.4-0.4
Bone: periosteal estimation1.02.14.0-1.61.9-1.0-0.8-0.9-1.42.01.5
Bone: periosteal perimeter2.74.613.4-1.13.50.40.70.6-0.23.03.7
Bone: post-yield work0.00.00.1-0.0-0.2-0.1-0.2-0.2-0.0-0.1-0.2
Progressive ratio test 1 active lever presses0.20.20.5-0.5-0.1-0.6-0.7-0.7-0.40.2-0.3
Progressive ratio test 1 breakpoint0.20.20.5-0.5-0.0-0.6-0.7-0.7-0.40.3-0.2
Progressive ratio test 1 inactive lever presses3.45.07.8-2.81.3-2.7-2.5-2.7-2.71.60.2
Progressive ratio test 2 active lever presses0.20.20.4-0.5-0.2-0.7-0.6-0.6-0.40.2-0.3
Progressive ratio test 2 breakpoint0.20.20.4-0.5-0.2-0.7-0.6-0.6-0.40.2-0.3
Progressive ratio test 2 inactive lever presses0.30.51.0-0.80.6-0.7-0.6-0.6-0.71.00.5
Incentive Sensitization - Responses0.00.00.1-0.20.0-0.2-0.3-0.3-0.20.1-0.1
Incentive Sensitization - Breakpoint0.00.10.1-0.20.0-0.3-0.3-0.3-0.20.1-0.1
Sum of active levers in priming session hrs 5-60.60.51.0-0.6-0.3-0.9-1.0-0.9-0.8-0.2-0.7
Progressive ratio0.30.50.90.9-1.00.60.60.40.8-0.7-0.7
Food seeking constrained by brief footshock0.10.10.20.4-0.20.40.40.50.3-0.4-0.2
Seeking ratio, punishment vs. effort0.10.20.5-0.50.3-0.4-0.5-0.2-0.7-0.1-0.1
Retroperitoneal fat weight4.016.926.1-5.12.5-4.8-4.8-4.7-4.93.10.5
Reaction time number correct3.16.09.8-2.0-1.5-3.0-3.1-3.1-2.6-0.5-2.5
Reaction time mean minus median0.30.81.30.90.21.11.11.21.1-0.10.7
Reaction time mean minus median AUC0.20.51.60.10.90.50.60.70.30.51.3
Reaction time num false alarms0.20.30.50.6-0.60.40.50.70.6-0.7-0.2
Reaction time num false alarms AUC0.30.50.80.8-0.90.60.60.90.7-0.9-0.4
Reaction time trials correct on left3.16.09.8-2.0-1.5-3.0-3.1-3.1-2.6-0.5-2.5
Reaction time trials on left3.36.110.0-2.1-1.4-3.1-3.1-3.2-2.6-0.5-2.5
Reaction time mean0.20.30.6-0.60.0-0.7-0.7-0.8-0.70.3-0.3
Reaction time mean AUC0.30.40.9-0.7-0.1-0.8-0.8-0.9-0.80.3-0.4
Median of all reaction times0.50.71.4-0.9-0.1-1.0-1.1-1.2-1.00.3-0.6
Reaction time omissions0.30.40.8-0.70.8-0.4-0.6-0.4-0.80.90.5
Reaction time false alarm rate2.02.85.51.8-0.12.02.12.42.0-0.50.9
Reaction time premature initiation rate1.01.42.81.3-1.70.70.80.71.1-1.6-1.3
Reaction time premature initiations1.32.46.7-0.0-2.3-1.1-1.1-1.2-0.5-1.7-2.6
Std. dev. reaction times0.10.30.50.6-0.70.40.30.40.4-0.7-0.6
Reaction time trials completed3.36.110.0-2.1-1.4-3.1-3.1-3.2-2.6-0.5-2.5
Reaction time trials AUC3.36.410.4-2.1-1.5-3.1-3.2-3.2-2.7-0.5-2.5
Run reversals in cocaine runway, females0.90.93.10.3-1.5-0.3-0.3-0.1-0.3-1.4-1.8
Run reversals in cocaine runway, males0.70.72.3-0.31.00.1-0.00.00.31.51.4
Latency to leave start box in cocaine runway0.50.51.20.8-1.10.40.40.20.8-0.8-0.8
Latency to leave start box in cocaine runway, F0.40.51.3-0.1-1.0-0.6-0.5-0.6-0.3-0.6-1.2
Latency to leave start box in cocaine runway, M0.70.71.51.1-0.61.00.70.61.2-0.6-0.1
Std. dev. time between licks in bursts1.62.23.8-1.5-0.4-2.0-1.9-1.8-1.8-0.6-0.9
Total sessions with >9 infusions0.20.30.60.6-0.80.30.10.00.4-0.5-0.8
Short access day 1 total inactive lever presses0.10.20.4-0.40.6-0.2-0.3-0.1-0.40.30.4
Short access day 10 total inactive lever presses1.74.17.2-2.71.9-2.2-1.8-1.9-2.51.71.0
Short access day 1 total infusions0.91.22.51.1-1.50.60.60.60.6-1.6-1.4
Short access day 10 total infusions0.50.71.0-1.00.8-0.7-0.8-1.0-0.50.90.8
Short access total infusions0.20.20.5-0.1-0.6-0.4-0.5-0.5-0.2-0.4-0.7
Short access day 1 locomotion0.30.40.80.9-0.40.80.70.50.9-0.4-0.1
Short access day 10 total locomotion0.40.81.50.90.21.11.21.01.10.10.8
Short access total locomotion0.40.50.90.70.20.90.90.60.90.20.6
One hour access (0.3 mA shock)0.40.50.8-0.6-0.5-0.9-0.9-0.9-0.6-0.1-0.9
Compulsive drug intake0.60.71.5-1.10.3-1.1-0.9-1.0-1.20.2-0.3
One hour access (shock baseline)0.00.00.20.00.00.00.0-0.10.30.40.3
Social response proportion0.20.30.7-0.2-0.5-0.4-0.4-0.5-0.6-0.4-0.9
Social responses0.20.30.7-0.6-0.0-0.7-0.7-0.4-0.8-0.2-0.4
Social time0.20.20.4-0.2-0.4-0.5-0.6-0.5-0.5-0.3-0.6
Soleus weight0.82.55.2-1.72.3-1.0-0.8-0.6-1.02.22.0
Bone: stiffness0.30.51.1-0.61.0-0.2-0.2-0.2-0.61.00.8
Tibialis anterior weight0.00.00.20.2-0.40.00.0-0.10.20.1-0.3
Time to tail flick, vehicle, before self-admin0.40.40.70.70.00.80.80.80.9-0.40.5
Time to tail flick, vehicle, after self-admin1.21.62.91.5-0.41.61.41.71.4-1.00.2
Time to tail flick, test, before self-admin0.70.71.30.9-0.40.91.11.01.0-0.50.2
Time to tail flick, test, after self-admin0.60.61.20.90.11.01.01.10.6-0.40.2
Delta time to tail flick, vehicle, before/after SA0.30.30.6-0.70.1-0.7-0.7-0.5-0.80.3-0.2
Delta time to tail flick, test, before/after SA0.20.20.40.6-0.10.60.40.50.2-0.2-0.2
Tibia length5.515.240.9-3.76.4-1.5-1.2-1.2-3.05.44.9
Ambulatory time before self-admin1.92.94.3-2.11.8-1.6-1.6-1.5-2.01.81.0
Ambulatory time after self-admin1.72.03.7-1.70.1-1.9-1.8-1.7-1.80.4-0.8
Bone: tissue strength2.22.23.8-2.01.0-1.8-1.6-1.7-1.61.30.3
Total heroin consumption0.20.30.4-0.50.5-0.4-0.6-0.5-0.70.60.0
Bone: trabecular number0.20.30.50.6-0.10.60.70.70.70.10.1
Bone: trabecular spacing3.85.08.4-2.1-0.5-2.7-2.9-2.9-2.8-0.1-1.9
Bone: trabecular thickness1.11.42.90.51.01.01.31.31.30.91.7
Bone: trabecular tissue density0.50.71.11.1-0.41.00.81.00.8-0.9-0.1
Water consumed over 24 hours0.30.30.70.40.40.60.60.80.80.20.6
Number of responses in last shaping day0.10.10.30.00.50.20.1-0.10.20.50.6