Nptx1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	mRNA stability	Nptx1	0.09	0.05	3.8e-05	0.05	0.09	0.07	0.06	9.0e-04	1.7e-05	8.4e-05	4.1e-04
2	Brain	gene expression	Nptx1	0.18	0.08	1.1e-16	0.11	0.19	0.18	0.18	2.6e-10	2.6e-17	6.3e-17	1.1e-16
3	Adipose	gene expression	Nptx1	0.09	0.05	4.0e-10	0.05	0.09	0.1	0.09	1.4e-06	2.2e-10	1.5e-11	3.1e-10
4	Liver	gene expression	Nptx1	0.07	0.04	9.0e-07	0.05	0.06	0.05	0.06	1.6e-06	7.6e-07	4.9e-06	8.0e-07
5	Brain	mRNA stability	Nptx1	0.15	0.1	7.4e-09	0.09	0.09	0.1	0.09	2.6e-08	5.5e-09	3.8e-09	1.8e-08
6	NAcc	gene expression	Nptx1	0.04	0.03	6.3e-05	0.04	0.03	0.05	0.04	8.2e-06	1.0e-04	2.5e-06	4.9e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.1	0.2	0.8	-0.4	-0.2	-0.4	-0.3	0.1	0.9
Area under the delay curve	0.5	0.5	1.7	1.3	-0.5	0.8	-0.6	-0.3	0.4
BMI with tail	0.7	2.1	4.2	-2.0	0.1	-0.7	-0.8	1.9	2.0
BMI without tail	4.1	8.5	18.1	-4.2	0.9	-2.2	-1.0	3.8	3.4
Body weight	3.0	12.6	18.9	-4.4	3.9	-4.2	2.2	4.2	1.5
Weight adjusted by age	3.0	3.4	7.4	-1.9	1.9	-2.7	1.4	1.5	1.2
Bone surface	0.2	0.4	0.7	-0.0	0.7	-0.8	0.8	0.0	-0.8
Bone volume	0.1	0.1	0.4	-0.4	0.2	-0.7	0.3	0.2	-0.1
Breakpoint value in progressive ratio session	0.3	0.4	1.2	-1.1	0.2	-0.5	-0.2	0.8	0.4
Number of licking bursts	0.1	0.2	0.2	-0.5	0.4	-0.5	0.2	0.5	0.3
Context. condit. distance diff. score	1.3	1.5	4.1	-1.5	-0.5	-0.0	-1.4	2.0	0.8
Locomotion velocity, session 1	2.6	2.8	6.8	2.6	-0.5	1.2	0.4	-2.3	-1.6
Locomotion distance, session 1	1.6	2.1	3.8	1.1	-1.9	2.0	-1.7	-1.0	0.3
Locomotion velocity, session 2	3.4	3.9	7.4	2.7	-1.8	2.1	-0.7	-2.7	-1.0
Locomotion distance, session 2	0.9	1.3	3.7	0.2	-1.2	0.9	-1.2	-0.6	1.9
Locomotion velocity, session 3	1.1	1.3	2.8	1.7	-0.7	1.2	-0.1	-1.5	-1.1
Locomotion distance, session 3	2.2	2.4	3.7	1.9	-1.7	1.9	-1.2	-1.6	-0.5
Stereotopy head waving bouts, day 3	0.4	0.5	1.5	0.8	-0.2	0.7	0.2	-0.5	-1.2
Stereotopy head waving duration, day 3	0.3	0.4	1.8	0.4	-0.2	0.5	-0.1	-0.0	-1.3
Locomotion velocity, session 7	0.7	0.7	1.0	0.7	-1.0	1.0	-0.9	-0.3	-1.0
Locomotion distance, session 7	3.2	4.0	8.3	0.9	-2.9	2.4	-2.8	-0.3	-1.0
Stereotopy head waving bouts, day 7	0.3	0.4	1.3	-0.7	0.4	-0.4	-0.0	1.1	0.0
Stereotopy head waving duration, day 7	0.7	0.8	1.6	-0.7	1.3	-1.0	0.9	0.9	-0.1
Locomotion velocity, session 8	1.0	1.2	2.3	-0.1	-0.9	1.1	-1.5	1.2	-1.2
Locomotion distance, session 8	2.1	3.0	5.4	-1.6	-1.4	0.6	-2.3	1.8	2.1
Degree of sensitization distance	0.8	0.8	2.0	-1.4	-0.3	-0.3	-0.8	1.4	0.3
Degree of sensitization stereotypy	0.6	0.7	1.8	-1.1	0.5	-0.7	-0.1	1.3	0.5
Conditioned locomotion	3.1	3.6	7.5	-2.7	1.2	-1.8	0.2	2.5	1.8
Cocaine response after cond. corrected	0.1	0.1	0.2	0.3	-0.3	0.5	-0.3	-0.3	0.1
Cocaine response after cond. not corrected	0.5	0.6	0.9	1.0	-0.6	0.9	-0.3	-0.9	-0.8
Cocaine response before conditioning	0.8	0.9	2.7	1.1	-0.7	0.8	-0.3	-0.8	-1.6
Saline control response	2.0	2.6	5.0	-1.7	1.9	-2.2	1.4	1.2	0.9
Bone: connectivity density	0.1	0.1	0.3	0.0	-0.5	0.2	-0.6	0.0	0.1
Bone: cortical apparent density	1.9	2.6	4.1	1.8	-1.8	2.0	-1.2	-1.8	-0.6
Bone: cortical area	4.7	7.1	11.6	-2.6	3.4	-3.4	2.6	2.2	1.3
Bone: cortical porosity	1.2	1.4	3.9	0.3	1.5	-1.1	2.0	-0.6	-0.6
Bone: cortical porosity	1.0	1.1	2.8	-0.1	1.4	-1.2	1.7	-0.0	-0.3
Bone: cortical thickness	4.2	6.9	11.3	-2.3	3.4	-3.3	2.7	1.6	2.0
Bone: cortical thickness	1.5	1.7	2.5	-1.3	1.6	-1.5	1.0	1.3	1.0
Bone: cortical tissue density	2.3	3.0	4.6	1.9	-2.0	2.2	-1.2	-1.9	-0.7
Condit. Reinf. active minus inactive responses	1.8	2.1	3.4	-1.8	1.1	-1.5	0.5	1.5	1.8
Condit. Reinf. active-inactive response ratio	1.0	1.1	2.1	-1.4	0.5	-0.8	-0.1	1.5	1.3
Condit. Reinf. active responses	3.0	3.7	5.4	-2.3	1.7	-2.2	1.0	1.7	2.3
Condit. Reinf. inactive responses	0.8	0.9	1.7	-1.0	0.8	-1.2	0.6	0.4	1.3
Incentive salience index mean	1.6	1.9	3.0	-1.6	1.3	-1.6	0.7	1.3	1.7
Condit. Reinf. lever presses	0.1	0.2	0.5	-0.5	0.0	-0.3	-0.1	0.3	0.7
Condit. Reinf. active minus inactive responses	1.2	1.5	2.5	-1.2	1.3	-1.1	0.5	1.4	1.6
Condit. Reinf. active-inactive response ratio	2.2	2.3	3.6	-1.3	1.9	-1.8	1.5	1.0	1.4
Condit. Reinf. active responses	0.7	1.0	3.2	-1.0	0.2	-0.3	-0.6	1.2	1.8
Condit. Reinf. inactive responses	0.8	1.0	2.5	0.1	-1.3	1.1	-1.6	0.2	0.6
Condit. Reinf. lever presses	1.2	1.6	3.4	-1.4	-0.6	-0.1	-1.4	1.3	1.8
Condit. Reinf. lever reinforcers received	1.3	1.8	5.2	-1.3	-0.3	-0.1	-1.2	1.5	2.3
Conditioned reinforcement - actives	0.4	0.4	1.8	-0.7	0.3	-1.3	0.2	0.2	0.4
Conditioned reinforcement - inactives	1.3	1.4	2.7	-1.3	1.2	-1.6	1.0	1.3	-0.1
Conditioned locomotion	0.5	0.6	1.7	-0.8	0.8	-1.3	0.8	-0.1	0.1
Patch foraging indifference point 0 sec	0.2	0.4	1.0	-1.0	-0.2	-0.2	-0.4	0.5	0.9
Patch foraging indifference point AUC	0.0	0.0	0.1	-0.3	-0.2	0.1	-0.3	0.2	-0.0
Delay disc. indifference point, 0s delay	0.2	0.2	0.4	0.0	0.6	-0.7	0.3	0.4	-0.0
Delay disc. indifference point, 16s delay	1.3	1.3	3.1	0.5	-1.4	1.1	-1.8	0.2	1.1
Delay disc. indifference point, 2s delay	0.1	0.1	0.3	0.5	0.4	-0.2	0.2	0.2	0.4
Delay disc. indifference point, 24s delay	2.6	2.5	5.6	2.4	-1.4	1.8	-0.7	-1.9	-0.3
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	0.5	0.1	-0.0	-0.2	0.3	-0.0
Delay disc. indifference point, 8s delay	0.5	0.5	2.3	1.5	0.2	0.5	0.3	-0.4	-0.3
Indifference point function ln k	0.7	1.0	2.0	0.9	-1.4	1.1	-1.2	-0.9	0.0
Indifference point function log k	0.7	1.0	2.0	0.9	-1.4	1.1	-1.2	-0.9	0.0
Patch foraging total patch changes 0 sec	0.4	0.7	1.4	-1.2	-0.5	-0.0	-0.8	0.7	1.2
Patch foraging total patch changes 12 sec	0.1	0.2	0.6	-0.6	-0.2	-0.0	-0.1	0.0	0.7
Patch foraging total patch changes 18 sec	1.1	1.4	2.9	-0.9	-1.2	0.8	-1.7	1.0	1.4
Patch foraging total patch changes 24 sec	1.0	1.3	2.8	-1.7	0.7	-0.9	0.1	1.5	1.1
Patch foraging total patch changes 6 sec	0.4	0.6	1.0	-0.8	0.7	-1.0	0.9	-0.2	0.7
Patch foraging time to switch 0 sec	0.4	0.6	1.8	1.4	-0.4	0.7	-0.0	-1.1	-0.1
Patch foraging water rate 0 sec	2.6	4.1	10.0	-3.2	1.0	-1.5	-0.2	3.1	1.3
Patch foraging water rate 12 sec	1.1	1.7	2.6	-1.5	-0.9	0.1	-1.6	1.6	1.4
Patch foraging water rate 18 sec	1.1	1.5	4.5	-2.1	-0.0	-0.6	-0.8	1.7	0.6
Patch foraging water rate 24 sec	3.9	5.4	12.2	-3.5	-0.3	-0.8	-1.8	3.3	2.3
Patch foraging water rate 6 sec	0.3	0.5	1.2	-1.1	-0.3	-0.2	-0.8	0.8	0.5
Seeking ratio, delayed vs. immediate footshock	1.6	1.8	4.7	-0.8	1.5	-2.2	1.2	0.6	1.3
Distance traveled before self-admin	0.9	0.9	1.7	-0.8	1.2	-1.3	0.8	1.0	0.4
Distance traveled after self-admin	0.7	0.8	1.7	-1.3	-0.4	-0.1	-0.9	0.8	1.1
Extensor digitorum longus weight	0.5	2.0	4.2	-1.5	-1.4	0.2	-2.0	1.2	1.5
Bone: elastic displacement	1.2	1.3	2.4	-1.3	1.1	-1.2	0.8	0.6	1.6
Bone: elastic work	4.7	6.0	9.9	-2.2	3.1	-3.1	2.7	1.2	1.6
Bone: endosteal estimation	0.1	0.3	0.8	-0.4	-0.6	0.2	-0.9	0.8	-0.2
Bone: endosteal perimeter	0.6	1.3	2.3	-0.6	1.5	-1.4	1.3	0.8	-0.8
Epididymis fat weight	1.0	2.3	5.2	-2.3	1.0	-1.4	0.1	2.3	0.8
Delta time in closed arm before/after self-admin	0.3	0.3	0.9	0.1	0.9	-0.3	0.9	-0.3	-0.1
Delta time in open arm before/after self-admin	0.7	0.7	1.6	-0.9	-0.3	-0.3	-0.8	0.8	1.3
Diff in mean of infusions in LGA sessions	0.0	0.0	0.1	-0.1	-0.1	-0.1	-0.1	0.3	-0.0
Delay discount exponential model param	0.7	0.8	2.5	-1.6	0.6	-1.0	0.6	0.5	-0.2
Extinction: sum of active levers before priming	1.0	1.0	2.0	0.8	-1.2	1.4	-1.0	-0.9	-0.2
Active lever presses in extinction session 6	0.2	0.2	0.6	-0.6	0.2	0.1	-0.2	0.8	0.4
Bone: final force	4.1	6.7	9.7	-2.7	3.0	-3.1	2.0	2.3	2.0
Bone: final moment	4.6	7.5	10.9	-2.9	3.2	-3.3	2.2	2.4	2.2
Food consumed during 24 hour testing period	0.7	0.9	2.8	-1.5	0.4	-0.1	-0.2	1.7	0.0
Glucose	2.6	3.9	8.9	2.8	-1.3	1.8	-0.0	-3.0	-1.3
Heart weight	0.2	0.3	0.7	-0.8	0.4	-0.7	0.3	0.5	0.4
Delay discount hyperbolic model param	0.6	0.7	2.2	-1.5	0.6	-0.9	0.6	0.4	-0.1
Intermittent access intake day 1-15 change	0.2	0.2	0.5	-0.3	0.4	-0.5	0.2	0.7	-0.5
Intermittent access intake escalation	0.3	0.3	0.8	-0.5	0.4	-0.6	0.1	0.9	-0.3
Intermittent access intake escalation 2	0.7	0.7	1.8	-0.5	1.0	-1.3	0.9	0.5	-0.2
Intermitt. access day 1 inactive lever presses	1.3	1.4	2.3	-1.4	1.4	-1.0	0.9	1.5	-0.2
Intermitt. access day 15 inactive lever presses	1.2	1.4	3.0	-1.7	0.7	-1.1	0.0	1.6	0.9
Intermitt. access escalation Index	1.3	1.1	1.9	-1.4	1.0	-1.0	0.5	1.3	0.9
Intermittent access day 1 total infusions	0.2	0.2	0.7	-0.5	0.3	-0.8	0.3	-0.0	0.2
Intermittent access day 15 total infusions	0.5	0.6	1.6	-0.9	0.7	-1.2	0.5	0.8	0.1
Intermittent access terminal intake (last 3 days)	1.1	1.2	3.7	-0.9	1.0	-1.9	0.9	0.6	0.2
Intermittent access total infusions	0.5	0.5	1.5	-0.8	0.6	-1.2	0.5	0.4	0.3
Intermittent access day 1 locomotion	0.4	0.4	1.0	-1.0	0.5	-0.8	0.4	0.5	0.4
Intermittent access day 15 total locomotion	0.6	0.7	1.6	-0.5	0.8	-1.3	0.9	0.3	-0.7
Intermittent access total locomotion	0.5	0.5	1.1	-1.0	0.7	-1.0	0.6	0.6	-0.3
Intermittent access standard deviation	0.2	0.2	0.5	0.7	0.2	0.4	0.2	-0.0	-0.7
Left kidney weight	0.6	1.8	4.0	0.2	1.9	-1.1	2.0	0.2	-1.3
Right kidney weight	0.3	0.9	2.3	-0.1	1.5	-0.7	1.4	0.5	-0.9
Cocaine induced anxiety	3.7	4.3	6.1	-2.1	2.5	-2.5	1.7	2.1	1.3
Post-drug Anxiety	0.8	0.9	3.3	-1.2	0.6	-0.3	-0.1	1.8	0.5
Baseline Anxiety	5.4	5.7	11.3	2.5	-2.7	3.4	-2.1	-1.7	-1.7
Tail length	4.0	12.0	19.7	-4.4	3.6	-4.2	2.2	3.7	1.7
Length with tail	2.7	9.9	18.3	-2.7	4.3	-3.9	3.5	2.6	-0.7
Length without tail	1.4	3.0	6.3	1.1	1.9	-0.7	2.5	-0.6	-2.5
Times rat made contact with spout	0.7	0.9	1.5	-0.9	1.2	-0.9	1.2	0.1	0.7
Lifetime Intake	0.1	0.2	0.6	-0.3	0.4	-0.8	0.4	0.0	0.1
Liver weight, left	0.3	0.5	1.0	0.8	0.7	-0.1	1.0	-0.5	-0.8
Liver weight, right	2.6	4.3	8.8	-1.3	3.0	-2.5	2.6	0.9	1.1
Locomotor activity	0.3	0.5	0.7	0.7	-0.9	0.8	-0.7	-0.6	-0.5
Locomotor testing distance	0.3	0.4	1.0	0.3	-0.9	0.8	-1.0	-0.1	-0.2
Locomotor testing rearing	0.6	0.9	1.8	-0.9	-0.7	0.3	-1.3	1.1	1.0
Locomotion in novel chamber	0.1	0.1	0.2	-0.5	-0.3	0.2	-0.5	0.3	-0.0
Locomotion in novel chamber post-restriction	0.5	0.6	1.1	-0.7	0.9	-0.9	1.0	0.2	-0.5
Fecal boli incidents, locomotor time 1	0.4	0.5	0.9	0.7	-0.9	0.7	-0.6	-0.7	0.4
Change in fecal boli incidents, locomotor task	2.7	2.6	4.2	2.0	-1.5	1.3	-0.6	-1.9	-1.9
Time >=10cm from walls, locomotor time 1	0.6	0.6	1.3	-0.5	-0.7	0.7	-1.1	1.0	0.1
Bouts of movement, locomotor time 1	1.6	1.8	3.2	1.5	-1.4	1.8	-0.9	-1.5	-0.1
Total resting periods, locomotor time 1	2.2	2.4	4.1	1.8	-1.5	2.0	-0.7	-2.0	-0.5
Rest time, locomotor task time 1	0.5	0.5	1.9	0.9	-0.1	0.0	0.6	-1.4	-0.3
Distance moved, locomotor task time 1	0.8	0.8	2.3	-1.1	0.7	-0.8	0.2	1.5	0.6
Vertical activity count, locomotor time 1	1.0	1.0	2.7	-1.4	0.3	-0.4	-0.4	1.6	1.0
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	-0.0	0.2	-0.3	0.4	0.1	-0.4
Bouts of movement, locomotor time 2	1.0	1.1	2.2	1.2	-1.1	1.5	-0.9	-0.9	-0.1
Total resting periods, locomotor time 2	0.7	0.7	1.4	0.9	-0.9	1.2	-0.8	-0.7	-0.0
Rest time, locomotor task time 2	0.3	0.3	0.7	0.5	-0.2	0.6	0.1	-0.7	-0.8
Distance moved, locomotor task time 2	0.5	0.6	1.5	-0.4	0.9	-1.2	0.6	0.7	0.5
Vertical activity count, locomotor time 2	0.5	0.5	1.3	-0.8	0.2	-0.5	-0.3	1.1	1.0
Light reinforcement 1	1.4	2.5	5.6	-2.3	0.6	-1.3	-0.2	1.5	2.4
Light reinforcement 2	1.8	2.4	3.5	-1.9	1.6	-1.8	1.0	1.4	1.5
Bone: marrow area	0.2	0.3	0.8	-0.4	-0.6	0.2	-0.9	0.8	-0.1
Bone: maximum diameter	1.6	3.0	5.8	-1.2	2.4	-2.0	1.9	1.5	-0.7
Bone: maximum force	3.8	6.6	10.3	-2.8	3.0	-3.2	2.1	2.2	2.0
Bone: maximum moment	4.3	7.4	11.3	-3.0	3.1	-3.4	2.2	2.3	2.1
Mean time between licks in bursts	0.9	1.2	2.5	1.3	-1.1	1.6	-0.7	-0.9	-0.7
Mean num. licks in bursts	0.1	0.1	0.2	-0.4	0.2	-0.0	0.2	-0.2	0.5
Cd content in liver	1.5	1.7	3.5	0.4	-1.7	1.9	-1.9	0.0	0.1
Co content in liver	0.2	0.2	0.6	-0.3	-0.7	0.4	-0.8	0.1	0.1
Cu content in liver	0.3	0.4	1.2	0.2	0.7	-0.7	1.1	-0.4	-0.4
Fe content in liver	0.7	0.8	1.5	0.6	-1.1	1.2	-0.9	-0.4	-0.8
K content in liver	1.5	1.4	2.5	-1.6	1.2	-1.5	0.8	1.2	0.7
Mg content in liver	0.4	0.4	0.7	-0.8	-0.4	-0.2	-0.6	0.6	0.8
Mn content in liver	0.4	0.4	0.8	-0.1	0.9	-0.6	0.8	0.4	-0.9
Na content in liver	0.2	0.2	0.5	0.3	0.6	-0.4	0.7	-0.5	-0.1
Rb content in liver	1.1	1.4	2.7	-1.6	0.1	-0.7	-0.5	1.5	1.6
Se content in liver	0.2	0.3	0.9	-0.8	0.1	-0.3	-0.2	0.9	-0.1
Sr content in liver	0.9	0.8	2.1	1.0	0.4	0.0	1.0	-1.5	-0.5
Zn content in liver	0.8	0.8	1.8	0.8	0.8	-0.4	1.3	-1.1	-0.7
Bone: minimum diameter	2.4	4.5	7.3	-2.4	2.5	-2.7	1.8	2.0	0.7
Time in familiar zone, hab. session 1	0.1	0.1	0.3	0.0	-0.6	0.4	-0.5	-0.2	-0.1
Time in novel zone, hab. session 1	0.1	0.1	0.1	-0.1	0.3	-0.2	0.0	0.4	-0.3
Total zone transitions, hab. session 1	0.6	0.8	1.7	-0.1	-1.2	1.0	-1.3	0.0	1.0
Total locomotion distance, hab. session 1	0.8	1.1	1.9	-1.4	-0.4	0.0	-1.1	1.2	1.4
Locomotion velocity, hab. session 1	0.7	1.1	2.3	-1.3	-0.4	-0.1	-0.9	1.2	1.5
Time in familiar zone, hab. session 2	0.4	0.4	1.0	-0.1	-0.9	0.8	-1.0	0.2	-0.1
Time in novel zone, hab. session 2	0.1	0.1	0.2	0.4	0.1	0.0	0.2	-0.2	-0.2
Total zone transitions, hab. session 2	1.3	1.7	3.5	-0.6	-1.5	0.8	-1.8	0.3	1.9
Total locomotion distance, hab. session 2	1.6	2.1	7.7	-1.5	-0.5	-0.3	-1.1	1.0	2.8
Locomotion velocity, hab. session 2	1.6	2.2	8.4	-1.7	-0.2	-0.6	-0.8	1.0	2.9
Novel to familiar place preference ratio	2.5	2.6	9.9	-1.6	0.8	-1.3	0.5	0.7	3.1
Novelty place preference	2.3	2.3	8.7	-1.4	0.9	-1.3	0.6	0.7	3.0
Time in novel zone, NPP test	2.1	2.1	8.5	-1.4	0.6	-1.1	0.3	0.7	2.9
Total zone transitions, NPP test	1.1	1.6	3.5	-0.4	-1.5	1.0	-1.9	0.4	1.5
Total locomotion distance, NPP test	1.9	2.6	8.2	-1.4	-1.2	0.3	-1.8	1.0	2.9
Locomotion velocity, NPP test	1.6	2.3	8.3	-1.5	-0.8	0.0	-1.4	0.9	2.9
Intraocular pressure	0.4	0.5	1.1	-1.1	-0.2	-0.4	-0.5	0.6	1.1
Delta distance traveled before/after self-admin	0.9	1.0	2.4	-0.6	-1.3	0.9	-1.5	0.2	0.8
Delta ambulatory time before/after self-admin	1.1	1.2	2.7	-0.0	-1.6	1.4	-1.6	-0.4	0.3
Parametrial fat weight	1.1	2.2	4.0	-1.6	1.6	-2.0	1.3	1.1	0.7
Pavlov. Cond. lever latency	2.4	3.0	8.5	-0.3	-2.3	1.8	-2.9	1.1	-0.1
Pavlov. Cond. magazine entry latency	2.2	2.9	5.8	-0.9	2.4	-2.1	2.4	0.6	-0.2
Pavlov. Cond. change in total contacts	0.4	0.5	0.9	0.0	0.6	-0.7	0.9	-0.7	0.8
Pavlov. Cond. index score	3.3	4.1	8.1	-1.1	2.9	-2.6	2.8	0.6	0.7
Pavlov. Cond. latency score	3.1	3.9	9.0	-0.7	2.8	-2.5	3.0	0.1	0.3
Pavlov. Cond. lever contacts	1.6	1.8	4.6	-0.2	1.8	-1.6	2.2	-0.6	0.7
Pavlov. Cond. magazine entry number	2.0	2.5	5.9	0.5	-2.3	1.9	-2.4	-0.2	0.4
Pavlov. Cond. intertrial magazine entries	0.5	0.5	1.5	-0.7	-0.6	-0.1	-0.8	0.5	1.2
Pavlov. Cond. lever-magazine prob. diff.	3.2	4.0	7.6	-1.3	2.8	-2.6	2.6	0.7	0.9
Pavlov. Cond. response bias	2.2	2.6	6.2	-0.6	2.3	-2.0	2.5	0.1	0.1
Pavlov. Cond. lever latency	1.6	2.1	4.8	1.9	0.4	0.6	1.2	-1.6	-2.2
Pavlov. Cond. magazine entry latency	2.2	2.5	6.7	-0.1	-2.3	1.7	-2.6	0.4	-0.2
Pavlov. Cond. change in total contacts	1.4	1.9	4.4	-0.8	-1.5	0.8	-2.1	0.8	1.6
Pavlov. Cond. index score	1.4	1.8	4.5	-1.1	-1.4	0.7	-2.1	1.2	1.1
Pavlov. Cond. latency score	1.4	1.8	4.1	-1.2	-1.3	0.6	-2.0	1.3	1.1
Pavlov. Cond. lever contacts	1.8	2.4	4.8	-2.1	-0.2	-0.7	-1.1	1.9	2.2
Pavlov. Cond. magazine entry number	2.1	2.5	7.1	0.4	2.2	-1.5	2.7	-0.6	-0.4
Pavlov. Cond. intertrial magazine entries	1.3	1.7	2.5	-1.3	1.6	-1.5	1.0	1.3	1.1
Pavlov. Cond. lever-magazine prob. diff.	1.5	1.9	5.1	-1.0	-1.6	0.9	-2.3	1.1	1.0
Pavlov. Cond. response bias	1.3	1.8	3.1	-1.4	-1.0	0.1	-1.7	1.3	1.8
Time in closed arm before self-admin	0.5	0.6	1.2	1.1	-0.6	1.0	-0.2	-0.8	-0.7
Time in closed arm after self-admin	1.6	1.6	2.9	1.7	-0.1	1.3	0.7	-1.4	-1.7
Time in open arm before self-admin	0.2	0.2	0.5	0.2	0.6	-0.4	0.7	0.0	-0.3
Time in open arm after self-admin	0.2	0.2	0.5	-0.4	-0.3	-0.2	-0.5	0.3	0.7
Bone: periosteal estimation	1.3	2.8	4.3	-1.9	1.9	-2.1	1.2	1.9	0.6
Bone: periosteal perimeter	3.0	5.0	10.5	-1.1	3.2	-2.8	3.1	0.9	-0.6
Bone: post-yield work	0.1	0.1	0.3	-0.3	-0.4	0.2	-0.5	0.1	0.5
Progressive ratio test 1 active lever presses	0.4	0.5	0.9	-1.0	0.6	-0.8	0.4	0.7	0.3
Progressive ratio test 1 breakpoint	0.5	0.5	1.1	-1.0	0.6	-0.9	0.4	0.7	0.3
Progressive ratio test 1 inactive lever presses	2.6	2.9	5.0	-2.2	1.5	-1.8	0.7	2.2	1.2
Progressive ratio test 2 active lever presses	0.3	0.4	0.9	-0.6	0.6	-1.0	0.6	0.3	-0.3
Progressive ratio test 2 breakpoint	0.4	0.4	0.9	-0.8	0.6	-1.0	0.5	0.5	-0.3
Progressive ratio test 2 inactive lever presses	0.6	0.7	1.5	-0.7	0.9	-1.2	0.7	0.6	-0.5
Incentive Sensitization - Responses	0.1	0.1	0.2	0.0	0.3	-0.3	0.4	-0.2	-0.5
Incentive Sensitization - Breakpoint	0.1	0.1	0.2	0.0	0.4	-0.3	0.4	-0.2	-0.5
Sum of active levers in priming session hrs 5-6	0.5	0.5	1.4	-0.8	-0.1	-0.0	-0.5	0.6	1.2
Progressive ratio	0.4	0.4	0.9	0.6	-0.8	0.2	-0.5	-0.9	0.6
Food seeking constrained by brief footshock	0.1	0.1	0.2	0.3	-0.3	0.4	-0.3	-0.1	0.3
Seeking ratio, punishment vs. effort	0.2	0.2	0.8	-0.4	0.4	0.2	-0.0	0.9	-0.2
Retroperitoneal fat weight	3.7	12.3	22.8	-4.8	3.3	-3.8	1.6	4.6	1.6
Reaction time number correct	2.5	3.6	7.3	-2.2	-1.6	0.4	-2.7	2.1	1.5
Reaction time mean minus median	0.3	0.4	0.8	0.9	0.3	-0.1	0.8	-0.7	-0.6
Reaction time mean minus median AUC	0.4	0.5	1.2	0.2	1.0	-0.7	1.1	0.1	-0.0
Reaction time num false alarms	0.2	0.3	0.5	0.5	-0.7	0.7	-0.5	-0.7	0.2
Reaction time num false alarms AUC	0.5	0.6	1.1	0.8	-1.0	1.1	-0.7	-0.7	-0.2
Reaction time trials correct on left	2.5	3.6	7.3	-2.2	-1.6	0.4	-2.7	2.1	1.5
Reaction time trials on left	2.6	3.7	7.4	-2.2	-1.7	0.4	-2.7	2.1	1.5
Reaction time mean	0.2	0.3	0.7	-0.6	0.1	-0.3	-0.3	0.8	0.8
Reaction time mean AUC	0.3	0.4	1.0	-0.8	-0.0	-0.3	-0.5	0.9	1.0
Median of all reaction times	0.4	0.6	1.1	-0.9	-0.1	-0.2	-0.6	1.1	1.0
Reaction time omissions	0.3	0.5	1.5	-0.7	0.5	-0.6	0.1	1.2	0.5
Reaction time false alarm rate	1.0	1.4	3.3	1.8	-0.1	0.7	0.7	-1.8	-0.9
Reaction time premature initiation rate	1.1	1.5	2.6	1.1	-1.6	1.6	-1.1	-1.1	-0.3
Reaction time premature initiations	1.8	2.5	6.2	-0.2	-2.3	1.7	-2.5	0.3	0.5
Std. dev. reaction times	0.2	0.3	0.6	0.6	-0.7	0.7	-0.6	-0.0	-0.3
Reaction time trials completed	2.6	3.7	7.4	-2.2	-1.7	0.4	-2.7	2.1	1.5
Reaction time trials AUC	2.6	3.8	7.4	-2.3	-1.6	0.4	-2.7	2.1	1.6
Run reversals in cocaine runway, females	1.2	1.1	3.1	0.1	-1.4	1.1	-1.7	0.1	0.6
Run reversals in cocaine runway, males	1.0	1.0	2.5	-0.1	1.0	-1.6	1.4	-0.4	-0.6
Latency to leave start box in cocaine runway	0.7	0.7	1.4	0.7	-1.0	0.9	-0.6	-1.2	-0.4
Latency to leave start box in cocaine runway, F	0.3	0.3	0.8	0.0	-0.9	0.5	-0.8	-0.4	-0.3
Latency to leave start box in cocaine runway, M	0.5	0.5	1.8	0.6	-0.4	0.6	0.1	-1.4	-0.1
Std. dev. time between licks in bursts	1.5	1.7	3.3	-1.7	-0.3	0.3	-1.2	1.7	1.8
Total sessions with >9 infusions	0.2	0.3	0.8	0.9	-0.4	0.1	-0.1	-0.6	-0.5
Short access day 1 total inactive lever presses	0.2	0.3	0.5	-0.3	0.7	-0.7	0.6	0.3	-0.3
Short access day 10 total inactive lever presses	2.6	2.8	4.3	-2.1	1.9	-1.9	1.1	2.0	0.4
Short access day 1 total infusions	0.7	0.8	1.4	1.2	-0.9	1.0	-0.5	-1.0	-0.5
Short access day 10 total infusions	0.4	0.5	1.0	-0.6	0.8	-1.0	0.8	0.2	0.2
Short access total infusions	0.0	0.0	0.2	0.2	-0.1	-0.0	0.0	-0.4	0.0
Short access day 1 locomotion	0.5	0.6	1.5	0.9	0.2	-0.2	0.7	-1.2	-0.7
Short access day 10 total locomotion	0.5	0.5	1.0	0.8	0.3	-0.3	0.7	-0.9	-1.0
Short access total locomotion	0.8	0.9	1.9	1.3	0.1	0.0	0.7	-1.4	-1.0
One hour access (0.3 mA shock)	0.7	0.8	2.2	-1.5	0.5	-1.0	0.1	1.1	0.6
Compulsive drug intake	0.5	0.5	1.4	-1.2	0.2	-0.1	-0.3	1.1	0.5
One hour access (shock baseline)	0.3	0.4	1.1	-0.3	0.6	-1.1	0.7	-0.1	0.1
Social response proportion	0.4	0.4	0.8	-0.1	-0.6	0.6	-0.9	0.5	0.8
Social responses	0.2	0.3	0.9	-0.6	-0.0	0.1	-0.5	1.0	0.6
Social time	0.3	0.4	1.0	-0.3	-0.6	0.3	-0.9	0.4	1.0
Soleus weight	1.1	3.3	5.9	-1.9	2.0	-2.4	1.7	0.6	1.8
Bone: stiffness	0.5	0.8	1.5	-0.7	1.2	-1.2	0.9	0.8	0.5
Tibialis anterior weight	0.0	0.1	0.2	-0.1	-0.5	-0.1	-0.4	-0.2	0.1
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.1	-0.3	0.3	-0.1	0.3	-0.3	0.3
Time to tail flick, vehicle, after self-admin	1.2	1.3	2.9	1.7	-0.8	1.3	-0.1	-1.3	-0.9
Time to tail flick, test, before self-admin	0.0	0.0	0.1	0.2	0.2	-0.1	0.4	0.1	-0.2
Time to tail flick, test, after self-admin	0.0	0.0	0.1	-0.0	0.2	0.0	-0.0	0.3	0.3
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.3	-0.1	-0.5	0.2	-0.6	0.4	0.1
Delta time to tail flick, test, before/after SA	0.2	0.1	0.2	0.5	-0.3	0.4	-0.5	-0.2	-0.2
Tibia length	7.3	20.7	42.8	-3.3	6.5	-5.5	5.2	3.6	0.5
Ambulatory time before self-admin	1.9	2.0	3.1	-1.4	1.7	-1.8	0.9	1.7	0.6
Ambulatory time after self-admin	0.7	0.7	1.7	-1.3	-0.1	-0.2	-0.7	1.1	1.1
Bone: tissue strength	1.7	1.7	4.2	-1.8	0.6	-1.1	0.1	1.1	2.0
Total heroin consumption	0.2	0.3	0.7	-0.2	0.5	-0.4	0.2	0.7	0.8
Bone: trabecular number	0.1	0.1	0.2	0.4	-0.1	-0.1	0.1	-0.5	0.2
Bone: trabecular spacing	2.5	3.3	8.1	-2.1	-0.5	0.1	-1.9	2.8	1.9
Bone: trabecular thickness	0.9	1.0	2.4	0.6	0.8	-0.9	1.5	-1.4	-0.2
Bone: trabecular tissue density	0.5	0.7	1.3	1.1	-0.4	1.0	-0.1	-0.7	-1.2
Water consumed over 24 hours	0.2	0.2	0.6	0.3	0.4	-0.2	0.7	-0.7	-0.3
Number of responses in last shaping day	1.6	1.7	3.0	-0.8	1.7	-1.7	1.5	0.6	0.9