Npepps

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL gene expression Npepps 0.34 0.21 1.3e-03 0.05 0.06 0.08 0.04 2.4e-02 1.3e-02 6.8e-03 4.6e-02
2 PL mRNA stability Npepps 0.03 0.03 8.5e-04 0.01 0.03 0.04 0.04 3.0e-02 2.0e-04 5.1e-05 9.3e-05
3 OFC gene expression Npepps 0.33 0.2 3.1e-03 0.13 0.04 0.11 0.11 6.6e-04 3.5e-02 1.8e-03 1.6e-03
4 Liver mRNA stability Npepps 0.15 0.08 3.2e-15 0.13 0.13 0.13 0.13 1.5e-14 3.9e-14 4.5e-14 2.6e-14
5 Adipose mRNA stability Npepps 0.39 0.12 0.0e+00 0.19 0.19 0.19 0.19 2.1e-20 2.4e-20 1.2e-20 1.9e-20
6 PL gene expression Npepps 0.32 0.12 0.0e+00 0.21 0.2 0.21 0.21 1.1e-22 4.7e-22 3.4e-22 1.8e-22
7 Brain mRNA stability Npepps 0.39 0.15 0.0e+00 0.23 0.24 0.24 0.25 2.5e-21 7.5e-22 5.5e-22 9.5e-23
8 BLA gene expression Npepps 0.45 0.18 9.7e-10 0.17 0.16 0.16 0.17 1.3e-09 3.6e-09 4.6e-09 1.4e-09
9 Brain gene expression Npepps 0.35 0.13 0.0e+00 0.19 0.2 0.2 0.21 1.3e-17 4.2e-18 1.1e-18 2.1e-19
10 NAcc gene expression Npepps 0.06 0.04 6.7e-05 0.04 0.03 0.03 0.03 2.4e-05 1.2e-04 5.6e-04 8.4e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density1.22.04.7-1.7-2.2-1.0-1.1-1.4-1.01.5-1.31.3-1.3
Area under the delay curve1.11.22.0-0.3-0.41.41.41.11.2-0.91.1-1.11.1
BMI with tail4.414.119.0-0.4-3.4-3.4-3.6-4.2-4.04.0-4.34.4-4.3
BMI without tail0.10.10.80.2-0.90.1-0.1-0.4-0.20.2-0.20.3-0.3
Body weight1.77.218.44.31.93.02.82.32.5-2.52.2-2.22.2
Weight adjusted by age0.40.51.20.61.10.40.60.70.4-0.60.8-0.60.8
Bone surface0.00.10.20.3-0.40.40.40.00.3-0.00.1-0.00.1
Bone volume0.20.31.2-0.3-1.1-0.2-0.2-0.5-0.30.5-0.50.5-0.5
Breakpoint value in progressive ratio session3.23.55.41.42.31.91.61.92.0-1.81.9-1.81.9
Number of licking bursts0.10.10.3-0.6-0.3-0.2-0.2-0.5-0.00.5-0.40.4-0.4
Context. condit. distance diff. score0.00.10.30.60.3-0.2-0.1-0.0-0.10.0-0.10.1-0.2
Locomotion velocity, session 10.20.20.30.50.1-0.4-0.3-0.5-0.40.4-0.50.5-0.5
Locomotion distance, session 13.74.76.12.32.52.12.12.12.2-2.22.1-2.12.1
Locomotion velocity, session 22.73.13.51.51.41.91.91.81.9-1.81.8-1.81.8
Locomotion distance, session 23.65.06.11.82.22.42.42.22.5-2.22.2-2.22.2
Locomotion velocity, session 30.30.30.50.30.20.60.60.70.6-0.70.6-0.70.6
Locomotion distance, session 34.04.34.71.51.92.22.12.12.2-2.22.2-2.22.2
Stereotopy head waving bouts, day 34.24.98.4-2.4-2.9-2.2-2.3-2.0-2.32.0-1.91.9-2.0
Stereotopy head waving duration, day 31.82.13.7-1.3-1.9-1.5-1.6-1.4-1.61.3-1.31.3-1.3
Locomotion velocity, session 71.81.92.31.01.21.51.51.51.5-1.41.5-1.41.5
Locomotion distance, session 74.45.66.51.22.02.52.52.62.5-2.42.5-2.52.5
Stereotopy head waving bouts, day 71.41.52.1-1.2-1.1-1.4-1.4-1.2-1.41.2-1.11.1-1.2
Stereotopy head waving duration, day 70.91.11.8-0.8-0.6-1.3-1.3-1.1-1.31.0-1.01.0-1.0
Locomotion velocity, session 80.91.15.22.31.60.50.70.60.6-0.70.5-0.50.4
Locomotion distance, session 81.72.53.51.91.81.51.51.61.5-1.61.5-1.51.4
Degree of sensitization distance0.10.10.10.40.30.20.30.30.3-0.30.3-0.20.3
Degree of sensitization stereotypy0.91.01.6-1.3-0.6-1.1-1.2-0.9-1.11.0-0.90.9-1.0
Conditioned locomotion0.20.21.1-0.4-1.0-0.3-0.3-0.4-0.20.4-0.50.4-0.3
Cocaine response after cond. corrected2.12.37.2-1.6-2.7-1.3-1.4-1.3-1.41.3-1.31.3-1.1
Cocaine response after cond. not corrected1.11.26.0-1.6-2.5-0.7-0.8-0.6-0.70.8-0.60.6-0.5
Cocaine response before conditioning0.91.11.7-0.20.61.11.01.21.3-1.11.3-1.21.2
Saline control response0.10.10.7-0.9-0.3-0.2-0.3-0.0-0.30.2-0.10.10.0
Bone: connectivity density0.71.13.0-1.7-1.5-0.7-0.7-0.9-0.61.1-0.90.9-0.8
Bone: cortical apparent density0.30.32.2-1.50.70.30.20.10.50.00.3-0.20.4
Bone: cortical area0.10.20.3-0.0-0.30.60.50.50.5-0.40.5-0.50.4
Bone: cortical porosity0.50.61.6-1.0-1.3-0.6-0.7-0.5-0.80.6-0.60.5-0.6
Bone: cortical porosity0.40.41.8-1.1-1.3-0.4-0.5-0.3-0.50.4-0.40.2-0.3
Bone: cortical thickness0.30.50.8-0.5-0.30.70.60.70.7-0.60.9-0.80.7
Bone: cortical thickness1.21.42.0-1.1-0.71.31.01.31.2-1.11.4-1.41.3
Bone: cortical tissue density0.30.42.2-1.50.70.40.20.20.5-0.00.3-0.20.4
Condit. Reinf. active minus inactive responses0.00.00.1-0.4-0.10.10.1-0.20.10.2-0.20.2-0.2
Condit. Reinf. active-inactive response ratio0.50.60.9-0.9-0.9-0.5-0.6-0.8-0.60.8-0.80.8-0.8
Condit. Reinf. active responses0.10.20.4-0.7-0.3-0.2-0.2-0.5-0.20.5-0.40.4-0.4
Condit. Reinf. inactive responses0.10.10.4-0.6-0.1-0.2-0.2-0.2-0.00.2-0.10.2-0.1
Incentive salience index mean0.10.10.7-0.9-0.30.1-0.0-0.20.10.3-0.20.2-0.2
Condit. Reinf. lever presses0.10.10.8-0.9-0.00.0-0.0-0.20.10.2-0.10.2-0.1
Condit. Reinf. active minus inactive responses0.40.51.2-1.1-1.1-0.4-0.4-0.6-0.40.7-0.70.6-0.6
Condit. Reinf. active-inactive response ratio1.21.31.6-1.0-1.0-1.1-1.1-1.2-1.11.2-1.31.2-1.2
Condit. Reinf. active responses0.30.51.7-1.3-1.1-0.3-0.4-0.5-0.40.7-0.50.5-0.5
Condit. Reinf. inactive responses0.30.32.2-1.5-1.0-0.1-0.2-0.1-0.10.3-0.00.1-0.1
Condit. Reinf. lever presses0.10.20.3-0.10.30.50.50.40.5-0.30.4-0.40.5
Condit. Reinf. lever reinforcers received0.20.31.5-1.2-0.9-0.2-0.3-0.3-0.30.5-0.30.4-0.3
Conditioned reinforcement - actives2.32.33.9-1.8-2.0-1.4-1.2-1.5-1.31.5-1.51.5-1.4
Conditioned reinforcement - inactives0.40.42.1-1.5-0.6-0.5-0.3-0.6-0.40.7-0.50.5-0.5
Conditioned locomotion3.44.18.3-2.0-2.9-1.9-1.6-2.0-1.82.0-2.02.0-1.9
Patch foraging indifference point 0 sec0.61.04.4-1.6-2.1-0.7-0.7-0.5-0.60.7-0.50.6-0.5
Patch foraging indifference point AUC0.10.10.70.50.80.10.0-0.1-0.10.1-0.20.2-0.3
Delay disc. indifference point, 0s delay0.40.40.7-0.7-0.10.70.20.80.7-0.60.7-0.80.7
Delay disc. indifference point, 16s delay0.30.30.9-0.4-0.90.70.90.40.5-0.30.4-0.40.4
Delay disc. indifference point, 2s delay0.91.01.2-0.9-0.91.11.01.11.0-0.81.0-1.11.0
Delay disc. indifference point, 24s delay0.90.92.30.60.51.21.50.91.0-0.80.9-0.81.0
Delay disc. indifference point, 4s delay5.86.28.60.60.92.92.72.82.8-2.52.8-2.72.7
Delay disc. indifference point, 8s delay0.30.30.5-0.6-0.50.60.70.40.5-0.30.5-0.40.5
Indifference point function ln k0.20.20.4-0.1-0.30.20.30.60.4-0.60.6-0.60.6
Indifference point function log k0.20.20.4-0.1-0.30.20.30.60.4-0.60.6-0.60.6
Patch foraging total patch changes 0 sec0.40.63.5-1.2-1.9-0.5-0.5-0.3-0.50.4-0.30.3-0.2
Patch foraging total patch changes 12 sec1.21.54.8-2.2-2.0-0.8-0.9-0.9-0.81.1-0.80.9-1.0
Patch foraging total patch changes 18 sec1.72.22.6-1.1-1.5-1.5-1.5-1.5-1.61.6-1.51.6-1.6
Patch foraging total patch changes 24 sec1.11.42.9-1.3-1.7-0.8-1.1-1.1-1.11.2-1.11.1-1.0
Patch foraging total patch changes 6 sec1.21.83.4-1.5-1.9-0.8-1.0-1.4-1.11.4-1.31.4-1.2
Patch foraging time to switch 0 sec0.30.40.6-0.6-0.6-0.5-0.5-0.8-0.40.8-0.70.8-0.6
Patch foraging water rate 0 sec0.20.30.70.5-0.40.80.50.50.4-0.50.5-0.50.4
Patch foraging water rate 12 sec1.01.62.01.20.91.41.31.31.2-1.41.3-1.31.3
Patch foraging water rate 18 sec1.01.41.90.00.11.31.21.31.4-1.21.4-1.41.4
Patch foraging water rate 24 sec0.10.21.3-0.6-1.20.4-0.1-0.1-0.10.2-0.20.1-0.2
Patch foraging water rate 6 sec0.00.00.3-0.5-0.2-0.2-0.30.0-0.10.1-0.0-0.0-0.2
Seeking ratio, delayed vs. immediate footshock0.40.50.7-0.2-0.3-0.8-0.8-0.7-0.80.7-0.80.8-0.7
Distance traveled before self-admin0.40.41.00.20.40.70.80.61.0-0.50.8-0.50.7
Distance traveled after self-admin0.10.10.50.7-0.3-0.4-0.4-0.1-0.20.1-0.10.2-0.1
Extensor digitorum longus weight1.45.422.44.73.01.92.21.51.7-1.81.3-1.31.3
Bone: elastic displacement0.10.10.2-0.3-0.5-0.2-0.2-0.2-0.30.2-0.20.2-0.1
Bone: elastic work0.30.40.60.40.00.80.70.60.7-0.60.6-0.60.7
Bone: endosteal estimation0.40.93.11.80.70.91.00.90.8-1.00.7-0.80.6
Bone: endosteal perimeter0.10.31.91.40.40.40.50.30.4-0.40.2-0.20.1
Epididymis fat weight0.30.71.40.90.41.20.90.90.9-0.80.8-0.80.8
Delta time in closed arm before/after self-admin0.60.62.31.51.30.40.60.30.5-0.40.5-0.20.4
Delta time in open arm before/after self-admin0.10.10.1-0.3-0.0-0.1-0.3-0.4-0.20.3-0.30.3-0.3
Diff in mean of infusions in LGA sessions0.10.10.80.20.90.0-0.1-0.1-0.20.1-0.10.1-0.2
Delay discount exponential model param1.61.73.0-0.10.2-1.7-1.7-1.4-1.51.2-1.41.4-1.4
Extinction: sum of active levers before priming1.51.51.81.31.31.20.71.31.2-1.31.3-1.31.3
Active lever presses in extinction session 60.10.10.30.0-0.1-0.3-0.5-0.5-0.20.5-0.30.5-0.4
Bone: final force0.20.21.5-0.9-1.20.0-0.1-0.00.00.1-0.00.0-0.2
Bone: final moment0.20.21.6-0.9-1.30.10.00.10.10.00.1-0.1-0.1
Food consumed during 24 hour testing period1.01.22.91.31.70.91.01.00.9-1.00.9-0.90.9
Glucose0.20.31.3-0.4-1.10.40.40.40.6-0.30.5-0.40.4
Heart weight0.20.22.11.40.5-0.10.10.0-0.0-0.1-0.00.1-0.1
Delay discount hyperbolic model param1.92.13.30.00.1-1.8-1.8-1.6-1.61.3-1.61.5-1.5
Intermittent access intake day 1-15 change0.80.81.6-0.5-1.3-0.9-0.8-1.0-0.80.9-0.90.9-0.8
Intermittent access intake escalation1.11.01.6-0.6-1.3-1.1-1.0-1.1-1.01.0-1.01.1-0.9
Intermittent access intake escalation 20.50.50.70.1-0.6-0.7-0.7-0.8-0.70.7-0.80.8-0.7
Intermitt. access day 1 inactive lever presses0.30.31.1-1.1-0.4-0.3-0.4-0.5-0.30.6-0.40.5-0.4
Intermitt. access day 15 inactive lever presses3.84.25.2-2.2-1.6-1.8-1.6-2.2-2.02.3-2.22.2-2.0
Intermitt. access escalation Index0.20.20.50.4-0.7-0.1-0.1-0.4-0.20.3-0.40.4-0.5
Intermittent access day 1 total infusions0.00.00.0-0.20.1-0.1-0.00.10.0-0.1-0.0-0.10.2
Intermittent access day 15 total infusions0.30.30.6-0.6-0.7-0.6-0.6-0.6-0.40.5-0.70.5-0.4
Intermittent access terminal intake (last 3 days)0.60.60.9-0.7-0.7-0.8-0.8-0.9-0.70.8-0.90.9-0.7
Intermittent access total infusions0.00.00.1-0.2-0.3-0.1-0.0-0.1-0.00.1-0.20.10.1
Intermittent access day 1 locomotion0.00.00.3-0.5-0.2-0.10.1-0.00.10.0-0.2-0.00.1
Intermittent access day 15 total locomotion0.50.60.9-0.7-0.7-1.0-0.8-0.7-0.80.7-0.80.7-0.5
Intermittent access total locomotion0.70.81.5-1.0-1.2-1.0-0.7-0.9-0.80.9-1.00.9-0.6
Intermittent access standard deviation0.70.81.3-0.6-1.1-0.9-0.9-1.0-0.70.9-0.91.0-0.7
Left kidney weight3.49.612.13.52.23.23.23.23.1-3.23.1-3.13.0
Right kidney weight1.02.73.61.90.41.81.71.71.8-1.71.6-1.71.6
Cocaine induced anxiety0.20.31.61.30.90.20.40.10.2-0.30.2-0.10.1
Post-drug Anxiety0.10.20.3-0.10.5-0.4-0.4-0.3-0.40.4-0.30.4-0.5
Baseline Anxiety2.22.45.1-2.3-1.4-1.5-1.4-1.3-1.51.6-1.51.4-1.6
Tail length14.945.252.14.45.47.06.97.17.1-7.17.2-7.27.1
Length with tail14.954.759.86.36.47.67.67.77.6-7.77.6-7.77.6
Length without tail2.65.79.83.12.42.22.42.42.1-2.52.2-2.32.2
Times rat made contact with spout0.10.20.5-0.7-0.4-0.3-0.3-0.4-0.20.4-0.40.3-0.5
Lifetime Intake0.00.00.1-0.1-0.1-0.1-0.0-0.2-0.00.2-0.30.20.1
Liver weight, left0.81.33.60.91.21.91.40.91.3-0.80.9-0.81.0
Liver weight, right3.05.07.51.21.12.72.52.32.6-2.22.4-2.32.4
Locomotor activity1.62.52.9-1.4-1.5-1.5-1.6-1.6-1.71.7-1.71.7-1.6
Locomotor testing distance4.47.38.8-3.0-2.7-2.6-2.8-2.6-2.72.8-2.72.6-2.6
Locomotor testing rearing2.53.87.1-2.7-1.7-2.1-2.1-1.7-1.91.9-1.81.7-1.7
Locomotion in novel chamber0.20.30.8-0.9-0.30.60.50.50.7-0.30.5-0.40.5
Locomotion in novel chamber post-restriction2.73.34.0-1.4-1.7-2.0-1.8-1.9-1.91.8-1.81.8-1.8
Fecal boli incidents, locomotor time 11.11.22.2-0.0-0.6-1.5-1.1-1.2-1.31.0-1.21.2-1.2
Change in fecal boli incidents, locomotor task1.41.31.80.40.91.31.01.31.2-1.21.3-1.21.3
Time >=10cm from walls, locomotor time 10.50.52.0-0.9-0.1-0.8-1.4-0.5-0.60.5-0.40.4-0.5
Bouts of movement, locomotor time 10.10.10.60.40.20.50.80.30.3-0.30.2-0.30.3
Total resting periods, locomotor time 10.30.31.10.60.10.61.00.40.5-0.40.4-0.40.5
Rest time, locomotor task time 10.10.10.4-0.1-0.40.20.7-0.10.20.20.20.20.3
Distance moved, locomotor task time 10.40.50.9-0.00.50.70.40.90.8-0.80.8-0.90.7
Vertical activity count, locomotor time 10.10.10.20.20.50.1-0.40.40.2-0.30.1-0.30.1
Time >=10cm from walls, locomotor time 20.10.10.8-0.9-0.2-0.1-0.40.10.1-0.10.3-0.20.2
Bouts of movement, locomotor time 20.20.30.5-0.6-0.5-0.6-0.6-0.4-0.70.3-0.40.3-0.5
Total resting periods, locomotor time 20.30.30.6-0.6-0.4-0.7-0.7-0.5-0.80.4-0.50.4-0.6
Rest time, locomotor task time 20.20.32.10.61.40.00.3-0.1-0.0-0.00.10.10.1
Distance moved, locomotor task time 21.71.92.90.70.21.61.41.61.7-1.41.6-1.51.5
Vertical activity count, locomotor time 21.11.21.80.6-0.31.31.11.21.4-1.11.1-1.21.2
Light reinforcement 12.24.05.7-2.4-2.0-2.0-2.0-1.9-1.92.0-1.91.9-2.0
Light reinforcement 20.30.40.8-0.9-0.9-0.5-0.4-0.5-0.40.7-0.60.6-0.6
Bone: marrow area0.40.93.01.70.70.91.00.90.8-1.00.7-0.80.6
Bone: maximum diameter0.00.10.5-0.1-0.7-0.0-0.0-0.1-0.10.2-0.20.2-0.3
Bone: maximum force0.10.20.50.1-0.70.50.30.40.4-0.30.4-0.40.2
Bone: maximum moment0.20.30.50.2-0.70.60.50.50.5-0.50.5-0.60.4
Mean time between licks in bursts0.10.10.60.80.5-0.10.0-0.1-0.20.0-0.10.1-0.1
Mean num. licks in bursts0.10.10.2-0.00.10.20.10.40.1-0.30.3-0.40.3
Cd content in liver0.10.10.2-0.20.5-0.0-0.00.4-0.1-0.30.2-0.30.3
Co content in liver0.20.31.21.10.90.30.30.40.2-0.40.3-0.30.3
Cu content in liver0.70.82.81.11.70.80.90.61.0-0.60.4-0.60.7
Fe content in liver2.93.53.91.81.82.02.01.81.9-1.91.8-1.91.8
K content in liver0.00.00.2-0.3-0.4-0.1-0.2-0.0-0.00.00.0-0.00.0
Mg content in liver0.10.10.1-0.20.30.20.20.30.3-0.30.4-0.40.2
Mn content in liver0.10.10.7-0.40.8-0.0-0.1-0.00.00.10.10.0-0.0
Na content in liver1.41.51.8-0.9-1.0-1.3-1.3-1.3-1.31.3-1.31.3-1.2
Rb content in liver0.91.22.3-1.5-1.0-0.8-0.8-1.1-0.91.2-1.11.1-1.1
Se content in liver0.30.41.3-1.1-1.0-0.4-0.5-0.4-0.30.4-0.40.3-0.3
Sr content in liver2.42.22.61.01.31.41.41.61.5-1.61.6-1.61.6
Zn content in liver0.91.02.8-1.7-1.2-1.0-1.1-0.7-0.90.7-0.70.6-0.8
Bone: minimum diameter0.71.31.71.20.51.21.11.21.1-1.31.2-1.21.0
Time in familiar zone, hab. session 10.50.40.6-0.70.1-0.7-0.7-0.7-0.70.7-0.60.7-0.7
Time in novel zone, hab. session 11.41.33.5-1.1-1.9-1.1-1.1-1.0-1.11.0-1.01.0-1.0
Total zone transitions, hab. session 14.46.110.72.33.32.42.52.42.5-2.32.3-2.32.3
Total locomotion distance, hab. session 10.91.32.00.51.41.21.21.11.3-1.11.1-1.11.2
Locomotion velocity, hab. session 12.43.54.41.42.12.01.91.82.0-1.81.8-1.81.9
Time in familiar zone, hab. session 21.51.61.8-1.1-0.9-1.3-1.3-1.4-1.41.3-1.31.3-1.3
Time in novel zone, hab. session 20.40.40.60.1-0.00.70.60.80.8-0.70.8-0.80.7
Total zone transitions, hab. session 20.71.02.51.01.60.90.90.91.0-0.90.8-0.80.8
Total locomotion distance, hab. session 20.00.00.00.10.10.10.00.10.2-0.10.0-0.10.1
Locomotion velocity, hab. session 20.20.20.40.50.40.50.50.40.6-0.50.4-0.40.4
Novel to familiar place preference ratio2.72.83.21.81.71.51.61.81.5-1.81.7-1.71.6
Novelty place preference2.62.73.11.61.61.51.61.81.5-1.71.7-1.71.6
Time in novel zone, NPP test1.61.72.11.11.11.21.21.51.2-1.41.4-1.41.3
Total zone transitions, NPP test1.72.43.61.11.91.61.61.51.7-1.51.5-1.51.6
Total locomotion distance, NPP test0.20.30.50.10.60.70.60.50.7-0.50.6-0.60.6
Locomotion velocity, NPP test1.11.52.00.91.21.31.31.21.4-1.21.2-1.21.3
Intraocular pressure2.02.83.61.71.91.61.61.61.6-1.61.8-1.61.8
Delta distance traveled before/after self-admin1.01.01.70.4-0.6-1.3-1.3-0.9-1.30.8-1.11.0-1.1
Delta ambulatory time before/after self-admin0.91.01.5-0.0-1.0-1.2-1.2-0.9-1.20.8-1.00.9-1.0
Parametrial fat weight0.20.31.5-1.2-1.2-0.1-0.2-0.2-0.10.3-0.20.2-0.4
Pavlov. Cond. lever latency0.20.32.31.50.40.00.10.1-0.1-0.30.1-0.10.2
Pavlov. Cond. magazine entry latency1.82.49.0-3.0-2.2-1.1-1.3-1.0-1.11.2-1.00.9-1.1
Pavlov. Cond. change in total contacts0.40.53.8-1.9-0.5-0.3-0.5-0.3-0.30.4-0.20.2-0.3
Pavlov. Cond. index score1.31.67.6-2.8-1.6-0.8-1.0-0.8-0.71.1-0.80.8-0.9
Pavlov. Cond. latency score0.81.05.6-2.4-1.3-0.6-0.7-0.6-0.50.8-0.50.5-0.7
Pavlov. Cond. lever contacts0.20.21.8-1.3-0.10.0-0.1-0.10.10.3-0.10.1-0.2
Pavlov. Cond. magazine entry number2.83.511.63.42.21.51.71.41.5-1.71.4-1.31.6
Pavlov. Cond. intertrial magazine entries1.01.22.01.41.41.01.10.91.1-1.01.0-0.91.1
Pavlov. Cond. lever-magazine prob. diff.1.41.88.3-2.9-1.8-0.9-1.0-0.9-0.71.1-0.80.8-1.0
Pavlov. Cond. response bias1.72.08.4-2.9-1.7-1.0-1.2-1.0-0.91.3-1.01.0-1.1
Pavlov. Cond. lever latency0.60.91.20.81.10.80.80.90.9-1.01.0-1.00.8
Pavlov. Cond. magazine entry latency0.91.01.20.60.71.11.01.11.1-1.01.1-1.11.1
Pavlov. Cond. change in total contacts0.40.61.3-1.0-1.1-0.5-0.6-0.7-0.70.8-0.70.7-0.5
Pavlov. Cond. index score0.10.10.5-0.3-0.7-0.1-0.1-0.2-0.10.2-0.20.2-0.1
Pavlov. Cond. latency score0.00.10.2-0.1-0.40.30.30.20.3-0.10.2-0.20.3
Pavlov. Cond. lever contacts0.81.01.8-1.2-1.3-0.9-0.9-0.9-1.01.0-1.01.0-0.8
Pavlov. Cond. magazine entry number0.20.20.40.00.3-0.7-0.6-0.5-0.70.4-0.50.4-0.6
Pavlov. Cond. intertrial magazine entries0.81.03.41.21.80.80.90.90.8-1.00.9-0.90.7
Pavlov. Cond. lever-magazine prob. diff.0.00.10.4-0.2-0.6-0.0-0.0-0.1-0.00.2-0.20.2-0.0
Pavlov. Cond. response bias0.50.72.0-1.2-1.4-0.7-0.7-0.7-0.70.8-0.70.7-0.6
Time in closed arm before self-admin1.21.33.4-1.7-1.8-1.0-0.7-0.9-1.01.0-1.00.9-1.0
Time in closed arm after self-admin0.00.00.10.2-0.2-0.20.3-0.1-0.00.2-0.10.2-0.1
Time in open arm before self-admin0.40.52.31.51.40.2-0.00.20.2-0.30.2-0.20.2
Time in open arm after self-admin0.20.30.70.40.9-0.3-0.7-0.5-0.50.3-0.40.5-0.4
Bone: periosteal estimation0.10.20.40.6-0.20.60.50.50.5-0.50.4-0.50.3
Bone: periosteal perimeter0.20.30.91.00.20.60.60.50.5-0.50.4-0.40.3
Bone: post-yield work0.20.31.21.10.50.50.50.50.4-0.60.4-0.50.4
Progressive ratio test 1 active lever presses0.20.20.4-0.7-0.60.10.10.30.3-0.30.4-0.40.6
Progressive ratio test 1 breakpoint0.30.30.6-0.6-0.40.30.30.50.5-0.50.6-0.60.8
Progressive ratio test 1 inactive lever presses0.50.51.5-1.2-1.1-0.4-0.4-0.7-0.40.7-0.60.6-0.4
Progressive ratio test 2 active lever presses0.30.30.8-0.9-0.6-0.5-0.5-0.5-0.40.5-0.60.4-0.3
Progressive ratio test 2 breakpoint0.20.20.6-0.8-0.6-0.5-0.4-0.4-0.30.4-0.50.4-0.3
Progressive ratio test 2 inactive lever presses0.20.20.3-0.20.3-0.5-0.5-0.5-0.50.5-0.50.5-0.4
Incentive Sensitization - Responses0.40.40.7-0.8-0.7-0.5-0.5-0.6-0.40.7-0.70.6-0.6
Incentive Sensitization - Breakpoint0.40.40.6-0.8-0.8-0.5-0.5-0.6-0.40.7-0.70.6-0.6
Sum of active levers in priming session hrs 5-61.11.11.80.41.41.00.81.11.1-1.01.1-1.11.1
Progressive ratio0.10.10.2-0.10.20.40.40.30.3-0.40.4-0.40.4
Food seeking constrained by brief footshock0.30.40.7-0.6-0.8-0.7-0.8-0.5-0.70.5-0.60.5-0.6
Seeking ratio, punishment vs. effort0.10.10.2-0.1-0.4-0.4-0.5-0.2-0.30.3-0.40.3-0.4
Retroperitoneal fat weight0.41.32.80.6-0.71.71.31.11.5-1.01.0-1.11.0
Reaction time number correct0.20.30.50.70.70.40.50.40.4-0.50.5-0.40.4
Reaction time mean minus median0.20.20.4-0.40.0-0.3-0.4-0.5-0.40.5-0.60.5-0.6
Reaction time mean minus median AUC0.60.81.4-1.2-0.4-0.8-0.9-0.9-0.81.0-1.00.9-0.9
Reaction time num false alarms0.10.20.6-0.7-0.2-0.8-0.50.2-0.3-0.20.2-0.3-0.1
Reaction time num false alarms AUC0.10.10.4-0.6-0.1-0.5-0.30.4-0.0-0.40.3-0.50.1
Reaction time trials correct on left0.20.30.50.70.70.40.50.40.4-0.50.5-0.40.4
Reaction time trials on left0.20.20.50.70.70.40.50.40.4-0.40.5-0.40.4
Reaction time mean1.01.42.0-0.7-0.5-1.3-1.2-1.3-1.11.2-1.31.3-1.4
Reaction time mean AUC0.91.21.7-0.6-0.4-1.2-1.1-1.2-1.01.2-1.31.2-1.3
Median of all reaction times1.62.23.0-1.1-0.9-1.7-1.5-1.6-1.41.5-1.61.5-1.7
Reaction time omissions0.20.30.8-0.9-0.8-0.4-0.4-0.3-0.40.5-0.40.4-0.4
Reaction time false alarm rate0.20.20.9-0.9-0.6-0.8-0.60.1-0.3-0.0-0.0-0.1-0.2
Reaction time premature initiation rate0.20.30.5-0.5-0.20.40.50.40.6-0.50.7-0.60.7
Reaction time premature initiations0.40.61.00.20.40.70.80.80.9-0.81.0-0.90.9
Std. dev. reaction times0.10.20.3-0.5-0.2-0.4-0.5-0.5-0.40.4-0.50.4-0.5
Reaction time trials completed0.20.20.50.70.70.40.50.40.4-0.40.5-0.40.4
Reaction time trials AUC0.10.20.50.60.70.30.40.40.3-0.40.4-0.40.3
Run reversals in cocaine runway, females1.81.82.71.61.21.11.31.41.0-1.41.3-1.41.4
Run reversals in cocaine runway, males4.44.35.5-1.4-1.3-2.0-1.9-2.3-2.22.3-2.42.3-2.4
Latency to leave start box in cocaine runway0.40.50.70.8-0.0-0.8-0.8-0.7-0.80.4-0.70.6-0.7
Latency to leave start box in cocaine runway, F0.50.50.70.6-0.6-0.8-0.8-0.8-0.80.6-0.70.7-0.8
Latency to leave start box in cocaine runway, M0.20.20.30.60.4-0.4-0.5-0.4-0.50.3-0.50.4-0.5
Std. dev. time between licks in bursts0.60.81.1-0.1-0.6-1.0-0.9-1.0-1.10.8-0.90.9-1.0
Total sessions with >9 infusions0.30.31.2-0.8-1.1-0.5-0.4-0.6-0.40.5-0.40.5-0.2
Short access day 1 total inactive lever presses0.20.21.1-1.00.40.40.50.00.30.10.1-0.10.2
Short access day 10 total inactive lever presses0.10.10.90.20.9-0.10.2-0.1-0.00.1-0.10.2-0.1
Short access day 1 total infusions0.20.20.3-0.4-0.2-0.3-0.2-0.5-0.20.5-0.50.5-0.3
Short access day 10 total infusions0.10.10.2-0.1-0.4-0.4-0.4-0.4-0.30.4-0.50.4-0.2
Short access total infusions0.00.00.00.1-0.00.00.0-0.10.10.0-0.10.10.1
Short access day 1 locomotion0.91.02.6-1.3-1.6-0.5-0.5-1.0-0.51.1-1.01.0-0.7
Short access day 10 total locomotion0.60.71.8-1.3-1.3-0.9-1.0-0.5-0.80.5-0.50.5-0.3
Short access total locomotion0.40.41.5-0.8-1.2-0.6-0.6-0.6-0.50.5-0.50.5-0.3
One hour access (0.3 mA shock)0.00.00.1-0.20.30.00.20.20.0-0.20.2-0.20.2
Compulsive drug intake3.23.34.90.71.72.22.21.82.0-1.71.8-1.81.7
One hour access (shock baseline)1.82.12.8-1.0-1.5-1.7-1.5-1.4-1.51.4-1.41.4-1.4
Social response proportion1.71.93.10.20.31.21.21.81.4-1.61.7-1.71.5
Social responses0.10.10.4-0.2-0.10.10.10.50.2-0.50.5-0.60.3
Social time0.50.71.4-0.4-0.0-1.2-1.1-0.8-1.10.7-0.80.8-1.0
Soleus weight0.31.04.0-1.2-2.0-0.6-0.7-0.7-0.60.8-0.80.8-0.8
Bone: stiffness0.10.20.40.1-0.20.50.40.60.5-0.60.6-0.60.3
Tibialis anterior weight0.72.54.82.21.91.61.71.31.6-1.41.2-1.21.2
Time to tail flick, vehicle, before self-admin0.30.31.20.21.10.40.40.50.3-0.50.5-0.50.6
Time to tail flick, vehicle, after self-admin0.40.40.6-0.4-0.5-0.5-0.8-0.8-0.40.7-0.60.8-0.6
Time to tail flick, test, before self-admin0.10.10.50.70.6-0.00.2-0.1-0.10.0-0.10.1-0.1
Time to tail flick, test, after self-admin0.10.10.20.50.20.40.40.30.2-0.30.3-0.30.3
Delta time to tail flick, vehicle, before/after SA0.90.91.8-0.8-1.3-0.7-0.9-1.1-0.61.1-0.91.1-1.0
Delta time to tail flick, test, before/after SA0.50.50.7-0.4-0.40.80.80.70.7-0.60.8-0.70.8
Tibia length0.31.02.61.60.31.11.10.90.9-0.90.8-0.80.8
Ambulatory time before self-admin0.30.30.70.40.40.60.60.60.8-0.60.6-0.60.6
Ambulatory time after self-admin0.20.21.71.30.0-0.1-0.20.30.1-0.30.2-0.20.2
Bone: tissue strength0.10.10.20.50.3-0.3-0.2-0.2-0.40.1-0.20.2-0.2
Total heroin consumption0.10.11.00.11.00.30.20.20.3-0.10.2-0.10.1
Bone: trabecular number2.03.26.4-2.5-2.4-1.4-1.5-1.7-1.31.8-1.61.6-1.6
Bone: trabecular spacing0.10.10.40.50.6-0.4-0.4-0.2-0.40.1-0.20.2-0.2
Bone: trabecular thickness0.10.10.90.0-0.90.20.2-0.00.1-0.00.0-0.10.1
Bone: trabecular tissue density0.00.00.1-0.00.20.20.20.20.2-0.20.3-0.20.2
Water consumed over 24 hours0.00.00.1-0.10.20.00.0-0.2-0.00.2-0.30.2-0.2
Number of responses in last shaping day0.40.40.70.20.3-0.7-0.8-0.8-0.70.6-0.60.7-0.5