Hub : Genes

Npb

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Npb	0.06	0.04	6.5e-05	0.01	0.04	0.04	0.03	1.8e-02	1.9e-04	1.5e-04	4.9e-04
2	Adipose	gene expression	Npb	0.04	0.03	1.3e-05	0.04	0.05	0.04	0.04	9.1e-06	4.0e-06	2.5e-05	1.6e-05
3	BLA	gene expression	Npb	0.34	0.16	3.8e-15	0.24	0.27	0.24	0.26	3.5e-13	1.6e-14	2.2e-13	5.4e-14
4	PL	gene expression	Npb	0.06	0.04	2.3e-06	0.04	0.06	0.05	0.06	9.1e-06	3.7e-07	5.0e-06	1.0e-06
5	Brain	alternative TSS	NM_153293.2	0.03	0.02	8.1e-03	0.02	0.01	0.01	0.02	3.4e-03	1.3e-02	5.3e-02	7.1e-03
6	Brain	alternative TSS	XM_039085299.1	0.03	0.02	6.2e-03	0.02	0.02	0.01	0.02	2.4e-03	8.9e-03	4.6e-02	5.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.1	0.2	0.7	0.3	-0.4	-0.7	-0.8	-0.0	0.0
Area under the delay curve	1.7	1.8	2.7	-1.6	1.4	1.3	1.3	-1.1	1.1
BMI with tail	0.4	1.4	3.4	0.6	-1.3	-1.8	-1.8	0.2	-0.2
BMI without tail	4.8	9.8	23.0	1.7	-3.3	-4.8	-4.7	0.3	-0.3
Body weight	3.3	13.8	18.6	4.2	-4.3	-4.2	-4.1	2.5	-2.5
Weight adjusted by age	2.2	2.5	3.5	1.7	-1.9	-1.4	-1.3	1.5	-1.5
Bone surface	0.3	0.5	1.0	1.0	-0.7	-0.6	-0.6	0.5	-0.5
Bone volume	0.2	0.4	0.6	0.7	-0.7	-0.7	-0.8	0.3	-0.3
Breakpoint value in progressive ratio session	0.7	0.8	2.0	0.1	-0.8	-0.1	0.2	1.4	-1.4
Number of licking bursts	0.2	0.3	0.6	0.7	-0.2	-0.6	-0.8	-0.3	0.3
Context. condit. distance diff. score	1.1	1.3	3.0	-0.1	-0.4	-1.5	-1.7	-1.1	1.1
Locomotion velocity, session 1	2.1	2.2	5.4	-1.1	1.5	2.2	2.3	-0.0	0.0
Locomotion distance, session 1	2.7	3.5	4.8	-2.2	2.1	1.3	1.0	-2.1	2.1
Locomotion velocity, session 2	3.8	4.4	6.8	-1.9	2.5	2.6	2.4	-1.4	1.4
Locomotion distance, session 2	0.7	0.9	1.9	-1.0	0.9	0.1	-0.1	-1.4	1.4
Locomotion velocity, session 3	1.6	1.8	3.6	-1.1	1.5	1.9	1.9	-0.4	0.4
Locomotion distance, session 3	2.8	3.1	4.2	-2.0	2.0	2.0	1.9	-1.2	1.2
Stereotopy head waving bouts, day 3	0.5	0.6	1.3	-0.4	0.8	1.1	1.2	-0.0	0.0
Stereotopy head waving duration, day 3	0.2	0.3	0.6	-0.3	0.6	0.8	0.7	-0.2	0.2
Locomotion velocity, session 7	0.7	0.8	1.1	-1.1	1.0	0.8	0.7	-0.8	0.8
Locomotion distance, session 7	3.3	4.2	6.3	-2.5	2.2	1.1	0.9	-2.5	2.5
Stereotopy head waving bouts, day 7	0.1	0.1	0.2	0.2	-0.4	-0.4	-0.4	0.2	-0.2
Stereotopy head waving duration, day 7	0.3	0.4	0.9	1.0	-0.7	-0.5	-0.5	0.6	-0.6
Locomotion velocity, session 8	1.0	1.2	2.6	-1.2	0.9	-0.0	-0.2	-1.6	1.6
Locomotion distance, session 8	1.8	2.7	4.6	-0.9	0.2	-1.5	-1.9	-2.2	2.2
Degree of sensitization distance	0.7	0.7	1.7	0.3	-0.6	-1.3	-1.3	-0.4	0.4
Degree of sensitization stereotypy	0.3	0.3	0.6	0.3	-0.7	-0.8	-0.8	0.3	-0.3
Conditioned locomotion	3.6	4.2	7.9	1.9	-2.3	-2.8	-2.8	0.7	-0.7
Cocaine response after cond. corrected	0.2	0.2	0.4	-0.5	0.1	0.4	0.6	0.5	-0.5
Cocaine response after cond. not corrected	0.4	0.5	1.0	-0.9	0.6	0.8	1.0	0.0	-0.0
Cocaine response before conditioning	0.8	0.9	1.4	-0.7	1.2	0.8	0.5	-1.2	1.2
Saline control response	2.7	3.6	4.7	2.1	-2.2	-2.1	-2.1	1.3	-1.3
Bone: connectivity density	0.2	0.4	0.8	0.1	0.2	-0.4	-0.6	-0.9	0.9
Bone: cortical apparent density	2.3	3.0	4.2	-1.9	2.0	2.1	2.0	-1.0	1.0
Bone: cortical area	5.9	8.8	11.6	3.4	-3.4	-2.8	-2.6	2.8	-2.8
Bone: cortical porosity	2.5	2.7	6.2	1.4	-1.2	0.3	0.7	2.5	-2.5
Bone: cortical porosity	2.2	2.4	5.2	1.4	-1.3	-0.1	0.3	2.3	-2.3
Bone: cortical thickness	5.2	8.6	11.3	3.4	-3.3	-2.3	-2.0	3.2	-3.2
Bone: cortical thickness	1.7	1.9	2.6	1.4	-1.6	-1.2	-1.0	1.6	-1.6
Bone: cortical tissue density	2.6	3.4	4.9	-2.1	2.1	2.2	2.2	-1.0	1.0
Condit. Reinf. active minus inactive responses	1.9	2.1	3.4	1.3	-1.7	-1.9	-1.7	0.9	-0.9
Condit. Reinf. active-inactive response ratio	0.8	0.8	1.3	0.6	-1.1	-1.2	-1.1	0.7	-0.7
Condit. Reinf. active responses	3.5	4.3	6.9	2.0	-2.4	-2.6	-2.5	1.1	-1.1
Condit. Reinf. inactive responses	0.9	1.1	1.9	1.1	-1.2	-1.4	-1.3	0.5	-0.5
Incentive salience index mean	1.5	1.8	3.0	1.3	-1.6	-1.7	-1.7	0.7	-0.7
Condit. Reinf. lever presses	0.1	0.2	0.4	0.0	0.1	-0.3	-0.5	-0.6	0.6
Condit. Reinf. active minus inactive responses	0.7	0.9	1.5	1.1	-1.1	-1.2	-1.2	0.3	-0.3
Condit. Reinf. active-inactive response ratio	2.2	2.3	3.9	2.0	-1.8	-1.4	-1.2	1.3	-1.3
Condit. Reinf. active responses	0.2	0.3	0.8	0.1	-0.5	-0.9	-0.8	-0.2	0.2
Condit. Reinf. inactive responses	0.7	0.8	2.1	-1.5	0.8	0.4	0.4	-1.0	1.0
Condit. Reinf. lever presses	0.3	0.4	0.9	-0.4	-0.4	-0.9	-0.9	-0.4	0.4
Condit. Reinf. lever reinforcers received	0.3	0.4	1.0	-0.3	-0.4	-1.0	-0.9	-0.4	0.4
Conditioned reinforcement - actives	0.3	0.3	0.6	0.4	0.1	-0.3	-0.6	-0.8	0.8
Conditioned reinforcement - inactives	1.3	1.4	2.0	1.4	-1.4	-1.1	-1.0	1.1	-1.1
Conditioned locomotion	0.1	0.2	0.8	0.9	-0.2	-0.1	-0.4	-0.2	0.2
Patch foraging indifference point 0 sec	0.1	0.1	0.2	-0.0	-0.4	-0.3	-0.3	0.5	-0.5
Patch foraging indifference point AUC	0.0	0.0	0.1	-0.3	0.0	-0.2	-0.2	-0.3	0.3
Delay disc. indifference point, 0s delay	0.1	0.1	0.1	-0.4	0.2	0.3	0.2	-0.3	0.3
Delay disc. indifference point, 16s delay	2.7	2.8	4.4	-2.0	1.6	0.8	0.6	-2.1	2.1
Delay disc. indifference point, 2s delay	0.4	0.4	0.7	-0.8	0.6	0.8	0.8	-0.3	0.3
Delay disc. indifference point, 24s delay	4.5	4.4	7.1	-2.1	2.3	2.7	2.6	-1.1	1.1
Delay disc. indifference point, 4s delay	0.3	0.3	0.5	-0.6	0.7	0.7	0.7	-0.3	0.3
Delay disc. indifference point, 8s delay	0.7	0.8	1.7	-0.9	0.9	1.2	1.3	-0.2	0.2
Indifference point function ln k	0.7	1.0	1.4	-1.2	1.2	1.0	0.9	-0.8	0.8
Indifference point function log k	0.7	1.0	1.4	-1.2	1.2	1.0	0.9	-0.8	0.8
Patch foraging total patch changes 0 sec	0.1	0.1	0.2	-0.3	-0.3	-0.4	-0.3	0.3	-0.3
Patch foraging total patch changes 12 sec	0.1	0.1	0.3	-0.2	-0.2	-0.1	0.1	0.5	-0.5
Patch foraging total patch changes 18 sec	0.4	0.5	1.6	-1.3	0.3	-0.3	-0.3	-0.8	0.8
Patch foraging total patch changes 24 sec	0.4	0.5	0.9	0.3	-0.9	-0.9	-0.9	0.5	-0.5
Patch foraging total patch changes 6 sec	0.4	0.6	1.1	0.7	-0.8	-0.5	-0.4	1.0	-1.0
Patch foraging time to switch 0 sec	0.3	0.5	0.9	-0.6	0.9	1.0	0.9	-0.4	0.4
Patch foraging water rate 0 sec	1.7	2.7	5.4	1.1	-1.9	-2.3	-2.2	0.7	-0.7
Patch foraging water rate 12 sec	0.4	0.6	1.2	-0.3	-0.4	-1.1	-1.1	-0.7	0.7
Patch foraging water rate 18 sec	0.7	0.9	2.4	0.4	-0.7	-1.4	-1.5	-0.5	0.5
Patch foraging water rate 24 sec	1.6	2.3	5.8	0.2	-1.4	-2.4	-2.4	-0.3	0.3
Patch foraging water rate 6 sec	0.2	0.3	0.5	-0.0	-0.2	-0.6	-0.7	-0.6	0.6
Seeking ratio, delayed vs. immediate footshock	1.4	1.6	2.2	1.3	-1.4	-1.5	-1.5	0.8	-0.8
Distance traveled before self-admin	1.7	1.8	3.6	1.0	-1.4	-0.6	-0.3	1.9	-1.9
Distance traveled after self-admin	0.4	0.5	1.3	0.0	-0.7	-1.1	-1.1	0.1	-0.1
Extensor digitorum longus weight	0.3	1.2	2.0	-0.6	-0.1	-1.2	-1.4	-1.3	1.3
Bone: elastic displacement	1.5	1.7	2.3	1.4	-1.4	-1.0	-0.8	1.5	-1.5
Bone: elastic work	7.8	10.1	14.9	3.3	-3.5	-2.2	-1.6	3.9	-3.9
Bone: endosteal estimation	0.2	0.5	0.8	-0.4	0.1	-0.6	-0.8	-0.9	0.9
Bone: endosteal perimeter	0.6	1.3	2.1	1.4	-1.3	-1.1	-1.1	0.9	-0.9
Epididymis fat weight	0.8	1.9	3.8	1.2	-1.5	-1.9	-2.0	0.4	-0.4
Delta time in closed arm before/after self-admin	0.4	0.4	1.0	1.0	0.3	0.2	-0.2	-0.7	0.7
Delta time in open arm before/after self-admin	0.1	0.1	0.5	-0.7	0.0	-0.2	-0.2	-0.2	0.2
Diff in mean of infusions in LGA sessions	0.2	0.3	0.6	-0.5	0.5	0.8	0.7	-0.1	0.1
Delay discount exponential model param	2.2	2.3	3.3	1.8	-1.7	-1.7	-1.7	1.0	-1.0
Extinction: sum of active levers before priming	1.4	1.4	2.7	-1.1	1.2	1.6	1.6	-0.3	0.3
Active lever presses in extinction session 6	0.8	0.8	1.6	-0.6	0.3	1.1	1.3	0.8	-0.8
Bone: final force	5.0	8.1	11.2	3.0	-3.3	-3.0	-2.7	2.5	-2.5
Bone: final moment	5.9	9.5	13.1	3.2	-3.6	-3.1	-2.8	2.9	-2.9
Food consumed during 24 hour testing period	0.3	0.4	0.5	0.5	-0.7	-0.7	-0.7	0.4	-0.4
Glucose	3.3	5.0	13.2	-1.7	1.6	3.1	3.6	0.9	-0.9
Heart weight	0.3	0.5	0.7	0.4	-0.8	-0.8	-0.6	0.6	-0.6
Delay discount hyperbolic model param	2.1	2.2	3.2	1.8	-1.6	-1.6	-1.6	1.0	-1.0
Intermittent access intake day 1-15 change	0.9	0.8	1.2	0.8	-1.1	-0.9	-0.7	1.0	-1.0
Intermittent access intake escalation	0.6	0.6	0.9	0.7	-1.0	-0.9	-0.8	0.7	-0.7
Intermittent access intake escalation 2	2.4	2.4	3.8	1.6	-1.7	-0.9	-0.7	2.0	-2.0
Intermitt. access day 1 inactive lever presses	1.1	1.2	1.7	0.9	-1.3	-0.9	-0.7	1.3	-1.3
Intermitt. access day 15 inactive lever presses	0.9	1.0	1.9	1.1	-1.0	-1.2	-1.4	0.1	-0.1
Intermitt. access escalation Index	1.0	0.8	2.1	0.8	-0.7	-1.2	-1.5	-0.4	0.4
Intermittent access day 1 total infusions	0.3	0.4	0.7	0.6	-0.7	-0.8	-0.8	0.3	-0.3
Intermittent access day 15 total infusions	0.6	0.7	1.3	0.8	-1.0	-1.1	-1.1	0.4	-0.4
Intermittent access terminal intake (last 3 days)	1.2	1.3	1.9	1.4	-1.3	-1.2	-1.2	0.9	-0.9
Intermittent access total infusions	0.6	0.6	1.1	0.8	-0.9	-1.0	-1.0	0.3	-0.3
Intermittent access day 1 locomotion	0.3	0.3	0.8	0.7	-0.5	-0.7	-0.9	-0.1	0.1
Intermittent access day 15 total locomotion	0.5	0.6	1.2	1.1	-0.8	-0.6	-0.6	0.7	-0.7
Intermittent access total locomotion	0.5	0.5	1.2	1.1	-0.8	-0.7	-0.8	0.4	-0.4
Intermittent access standard deviation	0.8	0.9	1.7	-0.3	0.2	1.1	1.3	1.1	-1.1
Left kidney weight	0.2	0.5	1.5	1.2	-0.4	0.2	0.1	0.8	-0.8
Right kidney weight	0.1	0.2	0.8	0.9	0.1	0.3	0.1	0.0	-0.0
Cocaine induced anxiety	5.4	6.2	11.7	2.0	-2.7	-1.4	-0.8	3.4	-3.4
Post-drug Anxiety	1.0	1.2	2.9	0.4	-0.9	-0.2	0.2	1.7	-1.7
Baseline Anxiety	7.0	7.5	10.2	-2.6	3.2	2.4	2.1	-3.0	3.0
Tail length	4.8	14.6	24.1	4.0	-4.3	-4.9	-4.9	1.7	-1.7
Length with tail	2.5	9.2	17.5	4.2	-3.4	-2.6	-2.6	2.6	-2.6
Length without tail	1.0	2.2	3.5	1.3	0.2	1.9	1.9	1.5	-1.5
Times rat made contact with spout	1.7	2.0	3.8	1.4	-1.4	-0.5	-0.2	1.9	-1.9
Lifetime Intake	0.2	0.2	0.3	0.6	-0.4	-0.5	-0.6	0.1	-0.1
Liver weight, left	0.4	0.6	1.1	0.1	0.1	0.9	1.1	0.9	-0.9
Liver weight, right	1.9	3.2	7.5	2.7	-1.9	-1.4	-1.6	1.3	-1.3
Locomotor activity	0.5	0.9	1.3	-1.0	1.1	1.1	1.1	-0.6	0.6
Locomotor testing distance	0.9	1.5	1.9	-1.3	1.4	1.1	0.9	-1.2	1.2
Locomotor testing rearing	0.4	0.7	1.0	-1.0	0.8	0.5	0.3	-1.0	1.0
Locomotion in novel chamber	0.4	0.5	1.0	-0.7	0.6	0.3	0.2	-1.0	1.0
Locomotion in novel chamber post-restriction	2.4	2.9	3.6	1.8	-1.9	-1.9	-1.7	1.4	-1.4
Fecal boli incidents, locomotor time 1	0.6	0.7	0.8	-0.9	0.9	0.7	0.5	-0.9	0.9
Change in fecal boli incidents, locomotor task	1.7	1.6	4.0	-1.0	1.1	1.7	2.0	0.5	-0.5
Time >=10cm from walls, locomotor time 1	0.9	0.9	2.1	0.6	-0.5	-1.3	-1.5	-0.7	0.7
Bouts of movement, locomotor time 1	1.5	1.6	2.2	-1.4	1.5	1.4	1.5	-0.8	0.8
Total resting periods, locomotor time 1	1.7	1.9	3.1	-1.3	1.6	1.7	1.8	-0.6	0.6
Rest time, locomotor task time 1	0.3	0.3	0.7	-0.1	0.3	0.8	0.9	0.4	-0.4
Distance moved, locomotor task time 1	0.5	0.5	1.1	0.7	-0.7	-1.0	-1.0	0.0	-0.0
Vertical activity count, locomotor time 1	1.0	1.1	2.6	0.9	-0.9	-1.4	-1.6	-0.4	0.4
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.6	0.8	-0.1	-0.2	-0.4	-0.3	0.3
Bouts of movement, locomotor time 2	1.3	1.4	2.2	-1.5	1.3	0.9	0.9	-1.2	1.2
Total resting periods, locomotor time 2	1.1	1.1	1.8	-1.2	1.1	0.6	0.5	-1.3	1.3
Rest time, locomotor task time 2	0.0	0.0	0.1	0.0	0.2	0.2	0.2	-0.2	0.2
Distance moved, locomotor task time 2	0.0	0.0	0.1	0.3	-0.1	-0.1	-0.2	-0.1	0.1
Vertical activity count, locomotor time 2	0.4	0.5	0.8	0.2	-0.0	-0.6	-0.8	-0.9	0.9
Light reinforcement 1	1.0	1.8	4.4	1.0	-1.2	-1.9	-2.1	-0.4	0.4
Light reinforcement 2	1.8	2.5	4.4	1.9	-1.7	-1.9	-2.1	0.4	-0.4
Bone: marrow area	0.2	0.5	0.8	-0.4	0.1	-0.6	-0.7	-0.9	0.9
Bone: maximum diameter	1.5	2.8	4.9	2.2	-1.8	-1.5	-1.6	1.3	-1.3
Bone: maximum force	4.9	8.5	11.8	3.1	-3.4	-3.2	-3.0	2.3	-2.3
Bone: maximum moment	5.7	9.8	13.7	3.3	-3.7	-3.3	-3.0	2.7	-2.7
Mean time between licks in bursts	1.4	1.9	2.7	-1.6	1.6	1.4	1.2	-1.3	1.3
Mean num. licks in bursts	0.5	0.7	1.7	0.1	-0.6	0.1	0.4	1.3	-1.3
Cd content in liver	1.8	2.0	3.8	-1.9	1.5	1.1	1.1	-1.3	1.3
Co content in liver	0.1	0.1	0.4	-0.6	0.4	0.4	0.3	-0.2	0.2
Cu content in liver	1.0	1.2	2.8	1.0	-0.7	0.3	0.5	1.7	-1.7
Fe content in liver	0.9	1.1	1.6	-1.3	1.2	1.0	0.9	-0.9	0.9
K content in liver	1.9	1.9	3.8	1.5	-1.3	-1.7	-2.0	0.3	-0.3
Mg content in liver	0.9	0.9	2.0	0.2	-0.1	-1.0	-1.4	-1.1	1.1
Mn content in liver	0.3	0.3	0.9	0.9	-0.6	-0.4	-0.4	0.5	-0.5
Na content in liver	0.0	0.0	0.2	0.4	-0.0	0.1	0.0	0.1	-0.1
Rb content in liver	0.9	1.1	2.6	0.6	-1.0	-1.6	-1.6	-0.1	0.1
Se content in liver	0.3	0.3	0.6	0.5	-0.6	-0.7	-0.7	0.2	-0.2
Sr content in liver	1.0	0.9	1.7	0.1	0.0	1.0	1.3	1.2	-1.2
Zn content in liver	0.1	0.1	0.5	0.7	0.1	0.4	0.2	0.2	-0.2
Bone: minimum diameter	3.0	5.6	7.3	2.6	-2.7	-2.1	-2.0	2.3	-2.3
Time in familiar zone, hab. session 1	0.1	0.1	0.2	-0.3	-0.0	0.2	0.4	0.3	-0.3
Time in novel zone, hab. session 1	0.1	0.0	0.1	0.1	0.0	-0.2	-0.3	-0.3	0.3
Total zone transitions, hab. session 1	0.4	0.6	1.4	-1.2	0.7	0.3	0.3	-0.9	0.9
Total locomotion distance, hab. session 1	0.2	0.3	0.5	-0.6	-0.1	-0.6	-0.7	-0.5	0.5
Locomotion velocity, hab. session 1	0.2	0.3	0.6	-0.5	-0.1	-0.7	-0.8	-0.4	0.4
Time in familiar zone, hab. session 2	0.3	0.3	1.0	-1.0	0.5	0.2	0.2	-0.5	0.5
Time in novel zone, hab. session 2	0.0	0.0	0.1	0.2	0.2	0.2	0.1	-0.2	0.2
Total zone transitions, hab. session 2	1.2	1.5	3.3	-1.2	0.7	-0.5	-0.7	-1.8	1.8
Total locomotion distance, hab. session 2	1.1	1.4	3.0	-0.2	-0.3	-1.5	-1.7	-1.3	1.3
Locomotion velocity, hab. session 2	1.1	1.5	3.7	0.1	-0.6	-1.7	-1.9	-1.0	1.0
Novel to familiar place preference ratio	2.9	3.0	4.8	1.6	-2.0	-1.2	-0.8	2.2	-2.2
Novelty place preference	2.9	2.9	4.8	1.6	-1.9	-1.1	-0.7	2.2	-2.2
Time in novel zone, NPP test	2.2	2.3	3.5	1.4	-1.7	-1.1	-0.7	1.9	-1.9
Total zone transitions, NPP test	1.7	2.4	5.3	-1.4	1.1	-0.3	-0.7	-2.3	2.3
Total locomotion distance, NPP test	1.4	2.0	3.6	-0.8	0.3	-1.2	-1.6	-1.9	1.9
Locomotion velocity, NPP test	0.9	1.3	2.3	-0.5	-0.0	-1.2	-1.5	-1.4	1.4
Intraocular pressure	0.5	0.7	1.7	0.3	-0.9	-1.3	-1.2	0.1	-0.1
Delta distance traveled before/after self-admin	1.0	1.1	2.2	-1.1	0.8	-0.1	-0.3	-1.5	1.5
Delta ambulatory time before/after self-admin	1.7	1.9	3.5	-1.4	1.4	0.5	0.2	-1.9	1.9
Parametrial fat weight	1.6	3.1	4.4	2.1	-2.0	-1.8	-1.7	1.4	-1.4
Pavlov. Cond. lever latency	1.8	2.3	4.5	-2.1	1.2	0.0	-0.1	-2.0	2.0
Pavlov. Cond. magazine entry latency	2.8	3.5	6.1	2.0	-2.0	-0.9	-0.5	2.5	-2.5
Pavlov. Cond. change in total contacts	1.1	1.1	2.7	0.7	-0.6	0.4	0.6	1.6	-1.6
Pavlov. Cond. index score	3.4	4.3	6.9	2.6	-2.2	-1.2	-1.0	2.4	-2.4
Pavlov. Cond. latency score	3.0	3.8	6.6	2.6	-2.0	-0.9	-0.7	2.4	-2.4
Pavlov. Cond. lever contacts	1.1	1.2	2.8	1.7	-1.0	-0.3	-0.2	1.3	-1.3
Pavlov. Cond. magazine entry number	2.9	3.7	7.3	-1.9	1.9	0.5	0.1	-2.7	2.7
Pavlov. Cond. intertrial magazine entries	0.5	0.5	1.4	0.1	-0.4	-1.1	-1.2	-0.6	0.6
Pavlov. Cond. lever-magazine prob. diff.	3.5	4.4	6.5	2.5	-2.3	-1.3	-1.0	2.4	-2.4
Pavlov. Cond. response bias	2.7	3.3	5.9	2.1	-1.8	-0.6	-0.3	2.4	-2.4
Pavlov. Cond. lever latency	0.6	0.8	2.0	0.1	0.7	1.4	1.4	0.4	-0.4
Pavlov. Cond. magazine entry latency	2.2	2.5	4.8	-2.2	1.6	0.7	0.5	-1.9	1.9
Pavlov. Cond. change in total contacts	0.6	0.8	2.1	-1.5	0.5	-0.3	-0.3	-1.1	1.1
Pavlov. Cond. index score	0.6	0.8	2.1	-1.4	0.5	-0.3	-0.3	-1.0	1.0
Pavlov. Cond. latency score	0.6	0.8	1.7	-1.3	0.4	-0.4	-0.5	-1.1	1.1
Pavlov. Cond. lever contacts	0.9	1.2	3.0	0.1	-0.9	-1.7	-1.7	-0.5	0.5
Pavlov. Cond. magazine entry number	1.8	2.1	4.5	2.1	-1.4	-0.5	-0.3	1.8	-1.8
Pavlov. Cond. intertrial magazine entries	1.5	2.0	2.8	1.6	-1.6	-1.7	-1.6	0.8	-0.8
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	2.6	-1.6	0.6	-0.2	-0.2	-1.1	1.1
Pavlov. Cond. response bias	0.5	0.6	0.8	-0.8	-0.1	-0.9	-0.9	-0.9	0.9
Time in closed arm before self-admin	0.4	0.4	0.7	-0.6	0.1	0.4	0.8	0.8	-0.8
Time in closed arm after self-admin	0.9	0.9	2.2	0.1	0.5	1.3	1.5	0.8	-0.8
Time in open arm before self-admin	0.4	0.5	0.9	0.7	0.5	0.3	-0.1	-1.0	1.0
Time in open arm after self-admin	0.4	0.4	0.9	-0.5	0.5	0.1	-0.2	-1.0	1.0
Bone: periosteal estimation	1.7	3.5	4.6	2.0	-2.2	-2.1	-2.1	1.3	-1.3
Bone: periosteal perimeter	3.6	5.9	9.2	3.0	-2.6	-1.6	-1.4	2.7	-2.7
Bone: post-yield work	0.3	0.3	0.7	-0.4	0.2	-0.4	-0.5	-0.9	0.9
Progressive ratio test 1 active lever presses	1.1	1.1	1.7	1.2	-1.2	-1.3	-1.3	0.5	-0.5
Progressive ratio test 1 breakpoint	1.4	1.5	2.3	1.3	-1.4	-1.5	-1.5	0.7	-0.7
Progressive ratio test 1 inactive lever presses	2.1	2.3	3.7	1.5	-1.7	-1.9	-1.9	0.8	-0.8
Progressive ratio test 2 active lever presses	0.5	0.5	1.0	1.0	-0.8	-0.7	-0.7	0.5	-0.5
Progressive ratio test 2 breakpoint	0.5	0.6	1.0	1.0	-0.8	-0.9	-1.0	0.2	-0.2
Progressive ratio test 2 inactive lever presses	0.4	0.5	0.9	0.9	-0.8	-0.5	-0.5	0.7	-0.7
Incentive Sensitization - Responses	0.2	0.2	0.4	0.6	-0.5	-0.6	-0.5	0.3	-0.3
Incentive Sensitization - Breakpoint	0.2	0.2	0.3	0.5	-0.5	-0.5	-0.4	0.4	-0.4
Sum of active levers in priming session hrs 5-6	1.1	1.0	2.3	-0.5	-1.0	-0.6	-0.1	1.5	-1.5
Progressive ratio	0.4	0.5	0.8	-0.8	0.8	0.9	0.8	-0.4	0.4
Food seeking constrained by brief footshock	0.3	0.3	0.8	-0.5	0.3	0.8	0.9	0.4	-0.4
Seeking ratio, punishment vs. effort	0.1	0.1	0.3	0.2	-0.4	-0.6	-0.5	0.1	-0.1
Retroperitoneal fat weight	3.8	12.4	16.7	3.6	-4.1	-4.1	-3.9	2.5	-2.5
Reaction time number correct	2.6	3.7	7.0	-1.2	0.4	-1.6	-2.0	-2.6	2.6
Reaction time mean minus median	0.3	0.3	0.7	0.4	0.2	0.8	0.8	0.5	-0.5
Reaction time mean minus median AUC	0.1	0.1	0.6	0.8	-0.1	0.3	0.2	0.1	-0.1
Reaction time num false alarms	0.2	0.3	0.7	-0.9	0.6	0.5	0.5	-0.2	0.2
Reaction time num false alarms AUC	0.6	0.8	1.3	-1.1	1.0	0.8	0.8	-0.7	0.7
Reaction time trials correct on left	2.6	3.7	7.0	-1.2	0.4	-1.6	-2.0	-2.6	2.6
Reaction time trials on left	2.7	3.8	7.3	-1.2	0.4	-1.6	-2.0	-2.7	2.7
Reaction time mean	0.2	0.2	0.4	0.5	-0.6	-0.7	-0.7	0.1	-0.1
Reaction time mean AUC	0.2	0.3	0.7	0.4	-0.4	-0.7	-0.8	-0.3	0.3
Median of all reaction times	0.2	0.3	0.8	0.3	-0.5	-0.9	-0.9	-0.1	0.1
Reaction time omissions	0.1	0.1	0.4	0.2	-0.2	-0.4	-0.6	-0.3	0.3
Reaction time false alarm rate	0.8	1.1	2.7	-0.5	0.7	1.5	1.7	0.7	-0.7
Reaction time premature initiation rate	1.2	1.6	3.2	-1.8	1.4	1.3	1.3	-0.8	0.8
Reaction time premature initiations	1.8	2.6	4.8	-2.2	1.4	0.2	0.1	-2.1	2.1
Std. dev. reaction times	0.2	0.3	0.5	-0.5	0.7	0.6	0.5	-0.6	0.6
Reaction time trials completed	2.7	3.8	7.3	-1.2	0.4	-1.6	-2.0	-2.7	2.7
Reaction time trials AUC	2.6	3.7	7.0	-1.1	0.3	-1.7	-2.1	-2.6	2.6
Run reversals in cocaine runway, females	1.2	1.1	2.6	-1.6	0.9	0.1	0.1	-1.3	1.3
Run reversals in cocaine runway, males	1.9	1.9	3.4	1.5	-1.4	-0.5	-0.3	1.8	-1.8
Latency to leave start box in cocaine runway	0.3	0.3	0.6	-0.7	0.6	0.2	0.1	-0.7	0.7
Latency to leave start box in cocaine runway, F	0.8	0.8	1.8	-0.7	0.8	0.1	-0.3	-1.4	1.4
Latency to leave start box in cocaine runway, M	0.1	0.1	0.3	0.2	-0.3	-0.2	-0.0	0.6	-0.6
Std. dev. time between licks in bursts	1.6	1.9	4.2	-0.2	-0.3	-1.7	-2.0	-1.5	1.5
Total sessions with >9 infusions	0.2	0.2	0.4	0.1	0.6	0.4	0.2	-0.7	0.7
Short access day 1 total inactive lever presses	0.5	0.6	1.5	0.2	0.3	-0.2	-0.6	-1.2	1.2
Short access day 10 total inactive lever presses	3.2	3.5	4.8	1.9	-2.2	-2.0	-1.7	1.7	-1.7
Short access day 1 total infusions	1.4	1.5	2.3	-1.0	1.4	1.5	1.3	-1.0	1.0
Short access day 10 total infusions	0.6	0.6	0.8	0.9	-0.9	-0.7	-0.6	0.8	-0.8
Short access total infusions	0.0	0.0	0.0	0.2	-0.0	-0.0	-0.0	0.0	-0.0
Short access day 1 locomotion	0.4	0.4	1.1	0.1	0.6	1.0	0.9	0.0	-0.0
Short access day 10 total locomotion	0.4	0.4	0.7	0.3	0.1	0.8	0.8	0.7	-0.7
Short access total locomotion	0.3	0.4	0.9	0.2	0.5	1.0	0.9	0.1	-0.1
One hour access (0.3 mA shock)	1.3	1.5	2.7	1.2	-1.4	-1.6	-1.6	0.5	-0.5
Compulsive drug intake	0.3	0.3	0.7	0.1	-0.6	-0.8	-0.8	0.2	-0.2
One hour access (shock baseline)	0.3	0.4	1.0	1.0	-0.4	-0.6	-0.8	-0.3	0.3
Social response proportion	0.5	0.6	0.9	-0.9	0.8	0.4	0.3	-1.0	1.0
Social responses	0.1	0.2	0.3	-0.3	0.5	0.3	0.1	-0.6	0.6
Social time	0.1	0.2	0.3	-0.4	0.4	0.1	-0.0	-0.6	0.6
Soleus weight	1.2	3.4	4.8	2.2	-2.1	-2.1	-2.2	1.0	-1.0
Bone: stiffness	0.6	1.0	1.6	1.0	-1.2	-1.2	-1.2	0.5	-0.5
Tibialis anterior weight	0.1	0.4	0.7	0.1	-0.1	-0.7	-0.8	-0.7	0.7
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	0.3	-0.2	-0.4	-0.4	-0.1	0.1
Time to tail flick, vehicle, after self-admin	1.9	2.0	3.0	-1.2	1.7	1.6	1.3	-1.4	1.4
Time to tail flick, test, before self-admin	0.2	0.2	0.3	0.4	-0.4	-0.1	-0.0	0.6	-0.6
Time to tail flick, test, after self-admin	0.3	0.3	0.7	0.1	0.6	0.9	0.6	-0.3	0.3
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	1.1	-0.6	0.8	0.4	0.1	-1.1	1.1
Delta time to tail flick, test, before/after SA	0.5	0.5	1.1	-0.5	0.7	1.1	1.0	-0.1	0.1
Tibia length	8.9	25.1	36.5	6.0	-5.7	-4.2	-3.6	5.1	-5.1
Ambulatory time before self-admin	2.6	2.7	4.4	1.4	-1.9	-1.2	-0.8	2.1	-2.1
Ambulatory time after self-admin	0.2	0.3	0.6	0.1	-0.6	-0.7	-0.7	0.2	-0.2
Bone: tissue strength	1.2	1.2	2.5	0.9	-1.1	-1.5	-1.6	0.2	-0.2
Total heroin consumption	0.5	0.6	1.3	-0.1	-0.3	0.6	0.8	1.1	-1.1
Bone: trabecular number	0.0	0.0	0.1	0.3	-0.1	-0.1	-0.2	-0.1	0.1
Bone: trabecular spacing	1.1	1.4	2.5	-0.8	-0.1	-1.3	-1.6	-1.4	1.4
Bone: trabecular thickness	1.3	1.6	3.5	1.1	-0.9	0.2	0.5	1.9	-1.9
Bone: trabecular tissue density	0.7	1.1	1.4	-1.1	1.2	1.1	1.1	-0.8	0.8
Water consumed over 24 hours	0.3	0.4	0.6	0.4	0.0	0.7	0.8	0.7	-0.7
Number of responses in last shaping day	0.7	0.7	1.7	1.3	-0.9	-0.8	-1.0	0.3	-0.3