Hub : Genes

Nova2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC mRNA stability Nova2 0.18 0.17 1.8e-03 0.1 0.12 0.13 0.12 2.4e-03 8.7e-04 6.2e-04 1.0e-03
2 IL gene expression Nova2 0.25 0.19 3.4e-04 0.14 0.12 0.15 0.14 2.5e-04 7.7e-04 2.2e-04 3.5e-04
3 BLA gene expression Nova2 0.2 0.12 1.2e-11 0.16 0.17 0.15 0.15 1.4e-08 2.4e-09 1.6e-08 2.1e-08
4 OFC gene expression Nova2 0.32 0.22 1.6e-05 0.15 0.2 0.16 0.18 1.9e-04 1.9e-05 1.2e-04 5.1e-05
5 PL gene expression Nova2 0.21 0.13 0.0e+00 0.21 0.21 0.21 0.21 1.6e-22 2.1e-22 5.7e-23 8.3e-23
6 IC gene expression Nova2 0.13 0.1 3.0e-04 0.07 0.07 0.08 0.07 5.8e-04 1.0e-03 2.8e-04 7.1e-04
7 NAcc gene expression Nova2 0.04 0.03 6.9e-06 0.03 0.03 0.02 0.02 4.3e-05 6.6e-05 1.1e-04 1.3e-04
8 NAcc mRNA stability Nova2 0.03 0.02 8.1e-06 0.03 0.03 0.02 0.03 6.2e-06 1.2e-05 6.0e-04 1.7e-05
9 PL mRNA stability Nova2 0.1 0.08 5.1e-09 0.08 0.08 0.09 0.08 3.6e-09 6.9e-09 4.1e-10 6.0e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.00.00.00.10.2-0.0-0.00.00.20.1-0.20.1
Area under the delay curve0.91.42.3-1.0-0.81.21.2-1.3-1.0-1.3-1.5-1.2
BMI with tail0.72.43.61.91.6-1.6-1.61.51.31.51.21.4
BMI without tail0.63.04.62.12.0-1.8-1.81.61.51.51.31.7
Body weight1.56.59.33.12.8-2.6-2.62.52.32.32.12.5
Weight adjusted by age0.00.00.30.10.3-0.1-0.1-0.1-0.5-0.0-0.0-0.0
Bone surface0.30.61.20.91.1-0.7-0.70.61.00.60.60.6
Bone volume0.20.40.70.70.8-0.6-0.60.50.80.60.40.5
Breakpoint value in progressive ratio session1.42.53.3-1.8-1.81.71.7-1.5-1.3-1.5-1.5-1.3
Number of licking bursts1.44.24.62.12.0-2.1-2.12.11.92.12.12.0
Context. condit. distance diff. score0.10.10.10.10.1-0.3-0.30.30.30.40.30.3
Locomotion velocity, session 10.10.10.2-0.4-0.40.30.3-0.2-0.2-0.1-0.3-0.2
Locomotion distance, session 10.00.00.0-0.1-0.00.00.0-0.1-0.10.00.1-0.1
Locomotion velocity, session 21.41.72.01.41.4-1.4-1.41.31.31.31.21.2
Locomotion distance, session 20.20.30.50.60.7-0.6-0.60.40.60.50.50.4
Locomotion velocity, session 30.20.30.40.60.6-0.6-0.60.50.60.40.40.4
Locomotion distance, session 30.80.91.1-1.0-1.00.90.9-1.0-0.8-1.0-0.9-1.0
Stereotopy head waving bouts, day 31.21.41.81.31.2-1.1-1.11.11.21.21.11.1
Stereotopy head waving duration, day 31.01.31.51.21.2-1.1-1.11.01.11.21.21.0
Locomotion velocity, session 70.30.30.5-0.7-0.70.50.5-0.4-0.3-0.5-0.4-0.4
Locomotion distance, session 70.00.00.10.20.2-0.1-0.10.10.2-0.10.20.1
Stereotopy head waving bouts, day 71.11.31.71.11.1-1.0-1.01.11.31.31.11.1
Stereotopy head waving duration, day 70.91.11.61.11.1-1.0-1.01.01.21.11.01.0
Locomotion velocity, session 80.00.00.1-0.3-0.10.10.1-0.2-0.0-0.1-0.1-0.2
Locomotion distance, session 80.00.00.00.10.2-0.0-0.0-0.00.1-0.0-0.0-0.0
Degree of sensitization distance0.60.70.91.01.0-0.8-0.80.80.80.70.80.7
Degree of sensitization stereotypy1.21.31.71.11.1-1.0-1.01.21.31.21.11.1
Conditioned locomotion0.10.10.1-0.3-0.30.30.2-0.2-0.3-0.3-0.3-0.2
Cocaine response after cond. corrected0.40.71.10.70.7-0.7-0.70.81.10.80.90.8
Cocaine response after cond. not corrected1.11.62.21.21.1-1.2-1.21.31.51.31.31.3
Cocaine response before conditioning1.62.02.31.51.4-1.4-1.41.51.21.41.31.4
Saline control response1.92.62.91.71.5-1.6-1.61.61.71.71.71.5
Bone: connectivity density0.00.00.1-0.10.10.10.1-0.20.0-0.3-0.3-0.1
Bone: cortical apparent density0.00.10.2-0.2-0.20.30.3-0.2-0.3-0.3-0.4-0.1
Bone: cortical area1.62.63.51.71.6-1.6-1.61.51.91.61.61.5
Bone: cortical porosity0.10.10.2-0.4-0.30.30.3-0.4-0.1-0.4-0.3-0.4
Bone: cortical porosity0.00.00.10.10.1-0.1-0.1-0.00.30.10.1-0.0
Bone: cortical thickness0.60.91.20.90.8-1.0-1.01.01.11.00.90.9
Bone: cortical thickness1.21.41.91.20.9-1.3-1.31.21.11.41.21.2
Bone: cortical tissue density0.10.10.3-0.3-0.30.40.4-0.3-0.4-0.4-0.5-0.2
Condit. Reinf. active minus inactive responses0.50.60.70.90.7-0.8-0.80.80.70.80.50.8
Condit. Reinf. active-inactive response ratio0.40.40.60.80.7-0.7-0.60.70.70.70.30.7
Condit. Reinf. active responses0.20.30.40.60.4-0.6-0.60.70.50.60.30.7
Condit. Reinf. inactive responses0.10.10.3-0.5-0.40.30.3-0.3-0.3-0.4-0.3-0.3
Incentive salience index mean0.40.50.60.80.6-0.7-0.70.80.60.70.40.8
Condit. Reinf. lever presses0.10.10.20.40.4-0.3-0.30.40.20.20.10.4
Condit. Reinf. active minus inactive responses0.00.00.10.10.1-0.2-0.20.20.10.30.20.2
Condit. Reinf. active-inactive response ratio0.10.20.40.40.3-0.5-0.50.40.30.50.60.4
Condit. Reinf. active responses0.10.10.2-0.4-0.40.30.3-0.3-0.4-0.2-0.4-0.3
Condit. Reinf. inactive responses0.50.71.0-0.9-0.80.90.9-0.8-0.9-0.7-1.0-0.8
Condit. Reinf. lever presses0.10.10.20.40.4-0.4-0.40.30.40.40.30.3
Condit. Reinf. lever reinforcers received0.10.20.3-0.4-0.40.40.4-0.4-0.5-0.3-0.4-0.4
Conditioned reinforcement - actives0.62.54.11.92.0-1.7-1.71.41.41.31.41.3
Conditioned reinforcement - inactives0.30.91.61.31.1-1.1-1.10.70.70.70.80.8
Conditioned locomotion1.72.62.91.61.6-1.6-1.61.61.51.61.71.6
Patch foraging indifference point 0 sec0.20.60.90.70.7-0.7-0.70.70.90.90.90.6
Patch foraging indifference point AUC2.15.16.02.32.1-2.3-2.32.42.22.12.22.5
Delay disc. indifference point, 0s delay0.80.81.3-0.6-0.40.91.0-1.1-0.8-1.1-1.2-0.9
Delay disc. indifference point, 16s delay0.60.91.5-0.8-0.60.90.9-1.1-0.7-1.1-1.2-1.0
Delay disc. indifference point, 2s delay2.83.14.2-1.6-1.41.71.7-1.8-1.8-1.9-2.1-1.7
Delay disc. indifference point, 24s delay0.00.00.30.10.1-0.1-0.10.10.50.2-0.0-0.0
Delay disc. indifference point, 4s delay0.00.00.20.40.5-0.1-0.10.10.0-0.0-0.10.2
Delay disc. indifference point, 8s delay0.91.51.8-1.2-1.11.31.3-1.2-1.0-1.3-1.4-1.1
Indifference point function ln k0.72.22.9-1.7-1.71.51.5-1.6-1.2-1.2-1.2-1.7
Indifference point function log k0.72.22.9-1.7-1.71.51.5-1.6-1.2-1.2-1.2-1.7
Patch foraging total patch changes 0 sec0.30.81.20.80.8-0.9-0.90.81.01.11.10.8
Patch foraging total patch changes 12 sec1.72.32.81.71.4-1.6-1.61.61.41.41.41.6
Patch foraging total patch changes 18 sec1.33.13.71.71.5-1.7-1.71.91.91.91.81.9
Patch foraging total patch changes 24 sec0.20.81.20.90.9-0.9-0.91.00.80.80.71.1
Patch foraging total patch changes 6 sec2.13.64.21.81.7-1.9-1.91.92.02.02.01.8
Patch foraging time to switch 0 sec1.14.45.0-2.1-1.92.12.1-2.1-2.2-2.1-2.2-2.0
Patch foraging water rate 0 sec1.45.35.82.42.1-2.3-2.32.22.32.42.42.1
Patch foraging water rate 12 sec0.00.10.30.40.3-0.4-0.40.30.50.50.40.2
Patch foraging water rate 18 sec0.00.10.10.30.3-0.3-0.30.1-0.10.30.3-0.0
Patch foraging water rate 24 sec0.40.51.00.60.3-0.7-0.70.80.71.00.80.7
Patch foraging water rate 6 sec0.60.81.01.01.0-0.9-0.90.80.91.00.80.8
Seeking ratio, delayed vs. immediate footshock1.72.53.5-1.9-1.81.61.6-1.4-1.6-1.5-1.5-1.3
Distance traveled before self-admin0.00.00.10.20.2-0.2-0.20.10.20.10.20.0
Distance traveled after self-admin0.20.40.5-0.6-0.60.50.5-0.6-0.7-0.5-0.5-0.7
Extensor digitorum longus weight2.08.09.73.13.0-2.9-2.82.82.72.62.72.8
Bone: elastic displacement0.70.91.3-1.1-1.11.01.0-0.8-1.0-0.8-1.0-0.7
Bone: elastic work0.00.10.10.30.1-0.3-0.30.30.10.30.10.3
Bone: endosteal estimation0.00.00.10.0-0.00.10.1-0.2-0.1-0.2-0.2-0.2
Bone: endosteal perimeter0.00.10.20.30.4-0.1-0.1-0.00.50.10.1-0.1
Epididymis fat weight0.10.71.6-0.9-1.00.70.7-0.7-1.3-0.7-0.8-0.7
Delta time in closed arm before/after self-admin0.30.30.5-0.7-0.70.50.5-0.4-0.6-0.4-0.4-0.6
Delta time in open arm before/after self-admin0.00.00.10.30.4-0.1-0.10.10.3-0.1-0.10.3
Diff in mean of infusions in LGA sessions0.91.62.2-1.5-1.51.41.4-1.1-1.2-1.1-1.2-0.9
Delay discount exponential model param0.71.01.70.80.6-1.0-1.01.10.81.11.31.0
Extinction: sum of active levers before priming0.00.00.1-0.1-0.20.20.20.10.20.1-0.10.0
Active lever presses in extinction session 60.20.20.50.70.5-0.4-0.40.30.30.40.40.3
Bone: final force0.50.81.11.01.0-0.9-0.90.91.00.90.80.9
Bone: final moment0.71.21.51.21.2-1.1-1.11.01.21.00.91.0
Food consumed during 24 hour testing period3.77.48.5-2.9-2.72.72.7-2.6-2.9-2.6-2.7-2.5
Glucose0.40.61.0-1.0-1.00.70.7-0.7-0.9-0.6-0.6-0.7
Heart weight1.83.03.71.91.6-1.7-1.71.71.61.81.91.5
Delay discount hyperbolic model param0.70.91.50.70.6-0.9-1.01.00.81.11.20.9
Intermittent access intake day 1-15 change0.00.20.20.40.5-0.5-0.40.30.30.40.30.3
Intermittent access intake escalation0.00.30.40.60.6-0.6-0.60.40.40.50.40.4
Intermittent access intake escalation 20.00.00.0-0.2-0.20.00.00.00.20.10.0-0.0
Intermitt. access day 1 inactive lever presses0.00.10.40.50.6-0.2-0.20.20.40.10.00.3
Intermitt. access day 15 inactive lever presses0.00.10.4-0.3-0.2-0.1-0.10.2-0.60.00.00.4
Intermitt. access escalation Index0.10.30.5-0.7-0.60.60.6-0.4-0.6-0.5-0.5-0.3
Intermittent access day 1 total infusions0.92.83.92.01.7-1.8-1.81.61.51.51.51.6
Intermittent access day 15 total infusions0.51.31.51.21.1-1.2-1.21.20.91.01.01.2
Intermittent access terminal intake (last 3 days)0.91.51.81.31.1-1.3-1.31.31.21.21.11.3
Intermittent access total infusions2.63.13.61.91.6-1.8-1.81.91.61.71.71.9
Intermittent access day 1 locomotion0.20.40.50.70.6-0.7-0.70.70.50.50.60.7
Intermittent access day 15 total locomotion0.00.20.30.40.2-0.5-0.50.3-0.10.50.50.3
Intermittent access total locomotion1.51.82.11.41.2-1.4-1.51.31.01.31.41.3
Intermittent access standard deviation0.00.20.3-0.5-0.40.50.5-0.4-0.2-0.4-0.5-0.3
Left kidney weight3.326.132.75.75.1-5.2-5.25.24.84.94.95.0
Right kidney weight3.524.429.15.44.8-4.9-4.95.15.04.84.74.8
Cocaine induced anxiety0.10.10.5-0.2-0.10.30.3-0.4-0.7-0.4-0.4-0.2
Post-drug Anxiety0.00.00.1-0.2-0.10.10.1-0.2-0.4-0.1-0.1-0.1
Baseline Anxiety0.10.20.9-0.7-0.90.40.4-0.0-0.00.00.0-0.3
Tail length0.42.13.41.81.9-1.5-1.51.31.21.21.21.3
Length with tail0.52.13.21.81.8-1.5-1.51.41.31.21.21.4
Length without tail0.21.31.61.21.1-1.1-1.11.20.91.11.01.3
Times rat made contact with spout0.10.10.3-0.4-0.50.30.3-0.3-0.3-0.2-0.2-0.2
Lifetime Intake2.63.33.92.01.7-1.9-1.91.91.71.71.71.9
Liver weight, left2.44.15.52.42.1-2.1-2.01.91.92.02.01.8
Liver weight, right1.93.45.12.32.1-1.7-1.71.82.01.61.41.7
Locomotor activity2.03.13.81.91.7-1.8-1.81.71.51.81.91.5
Locomotor testing distance0.82.02.71.71.6-1.5-1.51.21.11.31.61.1
Locomotor testing rearing2.59.111.23.33.1-3.1-3.12.92.82.93.02.8
Locomotion in novel chamber0.50.61.3-1.0-1.20.70.7-0.6-0.8-0.5-0.5-0.8
Locomotion in novel chamber post-restriction0.51.62.3-1.3-1.31.31.2-1.3-1.1-1.5-1.1-1.3
Fecal boli incidents, locomotor time 10.10.10.50.70.6-0.3-0.30.20.20.20.30.2
Change in fecal boli incidents, locomotor task0.50.60.7-0.8-0.80.80.8-0.8-0.4-0.8-0.9-0.7
Time >=10cm from walls, locomotor time 10.00.00.10.1-0.20.10.1-0.1-0.4-0.1-0.1-0.1
Bouts of movement, locomotor time 12.22.93.7-1.8-1.91.71.7-1.6-1.6-1.6-1.7-1.6
Total resting periods, locomotor time 13.23.74.6-2.0-2.11.91.9-1.8-1.9-1.8-1.9-1.8
Rest time, locomotor task time 10.20.30.6-0.6-0.80.50.5-0.4-0.5-0.5-0.4-0.4
Distance moved, locomotor task time 10.20.60.90.80.9-0.8-0.80.80.50.80.70.8
Vertical activity count, locomotor time 10.00.10.30.40.5-0.2-0.20.1-0.00.10.00.1
Time >=10cm from walls, locomotor time 20.10.20.7-0.5-0.40.20.2-0.3-0.8-0.3-0.2-0.3
Bouts of movement, locomotor time 22.48.010.0-3.2-3.02.92.9-2.7-2.7-2.7-2.8-2.5
Total resting periods, locomotor time 21.87.39.6-3.1-3.02.82.8-2.6-2.5-2.5-2.7-2.4
Rest time, locomotor task time 20.10.20.6-0.5-0.80.40.4-0.2-0.3-0.2-0.2-0.1
Distance moved, locomotor task time 20.81.01.40.91.2-1.1-1.11.00.91.00.90.9
Vertical activity count, locomotor time 20.00.10.20.30.5-0.0-0.0-0.1-0.2-0.2-0.2-0.2
Light reinforcement 10.00.10.30.50.4-0.3-0.30.20.20.20.40.2
Light reinforcement 20.20.41.00.91.0-0.6-0.60.40.40.10.40.5
Bone: marrow area0.00.00.00.10.10.00.0-0.1-0.0-0.1-0.1-0.1
Bone: maximum diameter2.44.86.12.32.2-2.1-2.12.12.52.22.12.1
Bone: maximum force0.20.40.50.70.7-0.6-0.60.60.70.60.50.6
Bone: maximum moment0.30.60.80.90.9-0.8-0.80.70.80.70.60.7
Mean time between licks in bursts0.00.00.1-0.2-0.10.20.2-0.2-0.1-0.2-0.3-0.0
Mean num. licks in bursts1.95.16.1-2.5-2.42.32.2-2.2-2.1-2.2-2.2-2.2
Cd content in liver0.20.20.5-0.6-0.70.40.4-0.2-0.5-0.3-0.3-0.2
Co content in liver1.31.52.0-1.4-1.31.21.2-1.1-1.4-1.2-1.2-1.0
Cu content in liver0.50.60.80.80.9-0.7-0.70.70.90.60.70.8
Fe content in liver4.55.66.62.32.0-2.4-2.42.52.12.62.52.4
K content in liver0.30.30.50.70.6-0.6-0.60.40.60.40.50.4
Mg content in liver0.70.81.11.10.9-0.9-0.90.80.80.80.80.8
Mn content in liver1.11.21.71.31.2-1.1-1.11.11.11.01.01.0
Na content in liver0.10.10.40.20.1-0.3-0.40.30.20.40.60.2
Rb content in liver0.00.00.10.30.2-0.3-0.20.10.10.20.30.1
Se content in liver4.55.36.42.52.4-2.3-2.32.22.42.22.22.1
Sr content in liver0.10.10.10.20.2-0.2-0.20.20.20.20.20.2
Zn content in liver1.11.31.81.31.3-1.1-1.11.01.30.91.01.0
Bone: minimum diameter0.20.50.90.80.8-0.6-0.60.50.90.60.60.5
Time in familiar zone, hab. session 10.10.10.30.30.3-0.3-0.30.20.30.30.50.2
Time in novel zone, hab. session 10.70.81.10.90.9-0.9-0.91.01.10.90.71.0
Total zone transitions, hab. session 10.10.10.20.20.1-0.3-0.30.20.00.40.40.2
Total locomotion distance, hab. session 10.40.60.7-0.7-0.60.70.7-0.8-0.8-0.8-0.8-0.8
Locomotion velocity, hab. session 11.31.82.1-1.3-1.21.31.3-1.4-1.5-1.4-1.4-1.4
Time in familiar zone, hab. session 20.40.40.60.80.8-0.6-0.60.60.70.70.60.6
Time in novel zone, hab. session 20.20.20.3-0.6-0.60.40.4-0.4-0.4-0.2-0.3-0.5
Total zone transitions, hab. session 20.50.60.80.80.8-0.8-0.80.70.70.90.90.6
Total locomotion distance, hab. session 20.50.60.9-0.7-0.60.80.8-0.9-0.9-0.7-0.8-0.9
Locomotion velocity, hab. session 20.30.50.7-0.6-0.50.60.6-0.8-0.8-0.7-0.7-0.7
Novel to familiar place preference ratio0.30.40.50.60.7-0.6-0.60.60.60.50.60.5
Novelty place preference0.20.30.40.50.6-0.6-0.60.50.50.40.60.4
Time in novel zone, NPP test0.30.40.50.60.7-0.7-0.70.50.70.50.70.5
Total zone transitions, NPP test0.10.10.20.30.3-0.3-0.30.20.30.40.40.2
Total locomotion distance, NPP test0.00.10.10.20.1-0.2-0.20.10.30.30.40.1
Locomotion velocity, NPP test0.00.00.10.10.1-0.2-0.20.10.10.20.30.0
Intraocular pressure0.10.10.3-0.4-0.50.20.2-0.0-0.60.0-0.1-0.2
Delta distance traveled before/after self-admin1.41.52.3-1.0-0.91.21.2-1.3-1.5-1.3-1.3-1.3
Delta ambulatory time before/after self-admin0.30.40.9-0.5-0.40.60.6-0.8-0.9-0.6-0.6-0.8
Parametrial fat weight0.10.10.20.4-0.0-0.4-0.40.50.40.40.30.4
Pavlov. Cond. lever latency0.50.70.8-0.9-0.80.80.8-0.8-0.8-0.9-0.7-0.8
Pavlov. Cond. magazine entry latency0.10.20.40.60.6-0.4-0.40.30.40.40.20.3
Pavlov. Cond. change in total contacts0.60.71.0-0.9-0.90.80.8-0.7-1.0-0.7-0.9-0.6
Pavlov. Cond. index score0.30.40.50.70.6-0.6-0.60.60.60.70.50.6
Pavlov. Cond. latency score0.10.10.10.40.3-0.3-0.30.30.20.40.20.3
Pavlov. Cond. lever contacts0.30.40.50.70.6-0.7-0.70.70.60.70.50.7
Pavlov. Cond. magazine entry number0.10.10.2-0.4-0.40.20.2-0.2-0.2-0.3-0.0-0.2
Pavlov. Cond. intertrial magazine entries0.10.10.20.0-0.0-0.2-0.20.40.40.20.30.4
Pavlov. Cond. lever-magazine prob. diff.0.30.40.50.70.7-0.6-0.60.60.60.70.50.6
Pavlov. Cond. response bias1.01.21.71.31.2-1.1-1.11.11.01.10.91.0
Pavlov. Cond. lever latency0.00.00.1-0.3-0.30.20.2-0.1-0.1-0.1-0.1-0.1
Pavlov. Cond. magazine entry latency0.00.00.00.0-0.0-0.0-0.00.1-0.10.0-0.00.1
Pavlov. Cond. change in total contacts0.20.40.5-0.6-0.60.60.6-0.7-0.7-0.6-0.6-0.7
Pavlov. Cond. index score0.00.00.1-0.1-0.10.20.2-0.2-0.3-0.2-0.2-0.2
Pavlov. Cond. latency score0.10.10.2-0.2-0.20.30.3-0.3-0.4-0.3-0.3-0.3
Pavlov. Cond. lever contacts0.10.10.30.50.5-0.4-0.30.30.30.30.20.3
Pavlov. Cond. magazine entry number0.30.40.70.60.6-0.6-0.60.60.90.70.70.6
Pavlov. Cond. intertrial magazine entries0.00.00.1-0.00.1-0.0-0.00.00.30.10.1-0.0
Pavlov. Cond. lever-magazine prob. diff.0.00.00.00.10.0-0.0-0.0-0.0-0.1-0.1-0.1-0.0
Pavlov. Cond. response bias0.00.00.00.10.10.00.0-0.0-0.1-0.1-0.1-0.0
Time in closed arm before self-admin0.61.01.61.11.2-1.0-1.01.00.90.80.91.0
Time in closed arm after self-admin1.11.21.3-1.2-1.11.11.1-1.0-1.2-1.1-1.0-1.1
Time in open arm before self-admin0.70.91.3-0.9-1.00.90.9-1.0-1.0-0.7-0.8-1.1
Time in open arm after self-admin0.00.00.0-0.1-0.10.10.1-0.10.1-0.0-0.20.0
Bone: periosteal estimation0.30.71.01.00.9-0.8-0.80.71.00.80.80.6
Bone: periosteal perimeter0.40.81.51.01.1-0.8-0.80.71.20.80.70.7
Bone: post-yield work0.50.91.2-0.8-0.60.90.9-1.0-1.0-1.1-1.1-1.0
Progressive ratio test 1 active lever presses2.13.85.42.32.2-2.0-2.01.81.81.71.81.7
Progressive ratio test 1 breakpoint2.13.55.62.42.1-1.9-1.91.81.81.61.61.6
Progressive ratio test 1 inactive lever presses0.82.03.01.71.7-1.6-1.61.21.01.31.31.2
Progressive ratio test 2 active lever presses2.53.55.12.32.2-1.9-1.91.81.71.71.71.7
Progressive ratio test 2 breakpoint3.13.95.52.42.3-2.0-2.01.91.81.81.81.8
Progressive ratio test 2 inactive lever presses0.20.71.81.21.4-0.9-0.90.60.50.40.50.6
Incentive Sensitization - Responses0.82.22.91.71.7-1.5-1.51.41.61.31.31.4
Incentive Sensitization - Breakpoint0.92.02.61.61.6-1.4-1.41.31.41.31.21.3
Sum of active levers in priming session hrs 5-60.20.20.4-0.4-0.60.60.6-0.20.1-0.3-0.4-0.2
Progressive ratio0.72.02.9-1.7-1.71.31.3-1.2-1.6-1.2-1.2-1.2
Food seeking constrained by brief footshock4.86.07.1-2.4-2.02.52.5-2.6-2.4-2.7-2.5-2.5
Seeking ratio, punishment vs. effort0.30.61.0-0.4-0.10.80.8-1.0-0.4-1.0-0.9-0.9
Retroperitoneal fat weight0.00.10.20.3-0.0-0.4-0.40.50.00.40.40.5
Reaction time number correct1.86.58.02.62.2-2.5-2.52.62.52.82.72.4
Reaction time mean minus median0.10.61.4-1.2-1.20.80.8-0.5-0.4-0.4-0.4-0.6
Reaction time mean minus median AUC0.00.10.1-0.3-0.30.00.00.20.30.30.30.2
Reaction time num false alarms4.06.99.23.02.8-2.7-2.72.72.32.52.42.6
Reaction time num false alarms AUC2.76.18.42.92.6-2.5-2.52.52.22.32.32.4
Reaction time trials correct on left1.86.58.02.62.2-2.5-2.52.62.52.82.72.4
Reaction time trials on left1.96.57.92.62.2-2.5-2.52.62.52.82.72.4
Reaction time mean1.02.13.0-1.7-1.61.61.6-1.3-1.1-1.4-1.4-1.3
Reaction time mean AUC0.71.62.3-1.5-1.41.41.4-1.2-0.9-1.2-1.2-1.1
Median of all reaction times1.32.12.5-1.6-1.51.61.6-1.4-1.2-1.5-1.5-1.3
Reaction time omissions0.00.00.10.20.2-0.1-0.10.20.3-0.0-0.10.2
Reaction time false alarm rate0.30.40.80.90.9-0.7-0.70.60.40.40.40.6
Reaction time premature initiation rate0.40.71.2-0.6-0.50.70.7-1.0-0.8-0.9-0.8-1.1
Reaction time premature initiations0.10.20.40.60.5-0.5-0.60.20.40.50.60.0
Std. dev. reaction times0.20.61.3-1.1-1.10.90.9-0.6-0.4-0.6-0.6-0.6
Reaction time trials completed1.96.57.92.62.2-2.5-2.52.62.52.82.72.4
Reaction time trials AUC2.38.09.62.92.5-2.8-2.82.82.83.13.02.7
Run reversals in cocaine runway, females0.40.50.9-0.8-0.70.60.6-0.7-0.9-0.7-0.5-0.7
Run reversals in cocaine runway, males0.40.50.60.80.4-0.6-0.60.80.80.70.70.7
Latency to leave start box in cocaine runway0.00.00.2-0.2-0.10.10.1-0.30.1-0.10.1-0.5
Latency to leave start box in cocaine runway, F0.20.30.50.40.4-0.6-0.60.30.70.60.7-0.0
Latency to leave start box in cocaine runway, M0.10.10.2-0.3-0.30.40.4-0.4-0.3-0.5-0.4-0.3
Std. dev. time between licks in bursts0.10.10.30.40.6-0.2-0.20.20.60.1-0.10.2
Total sessions with >9 infusions3.74.65.22.21.8-2.2-2.22.32.22.12.22.2
Short access day 1 total inactive lever presses0.81.63.21.71.8-1.2-1.21.11.30.80.81.2
Short access day 10 total inactive lever presses0.21.11.4-1.0-0.91.11.1-1.0-0.9-1.1-1.2-0.9
Short access day 1 total infusions1.52.93.41.71.5-1.7-1.71.81.91.71.71.8
Short access day 10 total infusions2.94.95.72.42.0-2.3-2.32.32.22.12.12.2
Short access total infusions2.33.23.81.91.7-1.8-1.81.91.81.71.71.8
Short access day 1 locomotion2.94.75.62.42.1-2.2-2.22.32.11.92.02.4
Short access day 10 total locomotion0.00.00.1-0.3-0.40.10.10.10.00.00.00.1
Short access total locomotion0.50.81.20.90.6-1.0-1.01.10.80.80.91.0
One hour access (0.3 mA shock)0.10.10.20.50.5-0.3-0.30.30.40.10.10.2
Compulsive drug intake0.10.10.10.20.2-0.3-0.30.30.30.40.40.2
One hour access (shock baseline)0.61.72.21.51.3-1.3-1.31.41.11.21.11.4
Social response proportion0.70.81.20.80.9-0.9-0.90.91.10.91.00.9
Social responses0.70.91.01.00.9-1.0-1.01.01.00.91.00.9
Social time3.25.15.8-2.2-2.12.12.1-2.4-2.4-2.3-2.3-2.4
Soleus weight0.10.30.40.60.5-0.6-0.60.60.20.50.60.5
Bone: stiffness0.71.31.61.31.2-1.2-1.21.11.11.11.21.1
Tibialis anterior weight3.512.214.73.83.7-3.5-3.53.33.53.33.43.3
Time to tail flick, vehicle, before self-admin2.43.03.41.81.5-1.7-1.71.81.81.81.81.6
Time to tail flick, vehicle, after self-admin0.00.00.1-0.3-0.30.20.2-0.20.00.00.1-0.3
Time to tail flick, test, before self-admin0.20.20.4-0.5-0.50.60.6-0.2-0.2-0.5-0.6-0.2
Time to tail flick, test, after self-admin0.10.20.50.00.10.30.3-0.5-0.3-0.5-0.4-0.7
Delta time to tail flick, vehicle, before/after SA0.20.20.4-0.6-0.50.50.5-0.5-0.3-0.4-0.4-0.5
Delta time to tail flick, test, before/after SA0.60.71.01.01.0-0.9-0.90.60.80.80.80.5
Tibia length0.30.71.21.11.0-0.9-0.90.90.70.80.60.9
Ambulatory time before self-admin0.00.00.1-0.2-0.20.10.1-0.10.3-0.0-0.1-0.1
Ambulatory time after self-admin0.50.81.0-1.0-1.00.80.8-0.9-0.9-0.7-0.7-1.0
Bone: tissue strength0.70.71.1-0.8-0.60.90.9-0.9-0.7-1.0-1.0-0.8
Total heroin consumption0.00.10.20.30.3-0.1-0.00.10.4-0.0-0.10.2
Bone: trabecular number0.00.00.2-0.3-0.10.20.2-0.2-0.2-0.1-0.4-0.1
Bone: trabecular spacing0.00.00.10.20.1-0.1-0.20.10.10.10.40.0
Bone: trabecular thickness1.31.82.31.31.2-1.3-1.31.41.51.51.11.3
Bone: trabecular tissue density0.20.30.50.70.4-0.6-0.60.60.40.70.60.5
Water consumed over 24 hours0.20.30.6-0.7-0.80.60.6-0.5-0.7-0.5-0.5-0.5
Number of responses in last shaping day2.63.44.51.71.5-1.7-1.72.11.91.81.92.0