Hub : Genes

Nod2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Nod2 0.18 0.11 6.0e-13 0.1 0.11 0.11 0.11 3.9e-11 5.5e-12 1.9e-12 2.7e-12
2 Brain gene expression Nod2 0.22 0.1 0.0e+00 0.28 0.29 0.3 0.3 1.0e-26 1.4e-27 3.0e-28 3.8e-28
3 Adipose gene expression Nod2 0.02 0.02 2.8e-03 0.01 0 0.01 0 6.7e-03 1.4e-01 4.6e-02 1.3e-01
4 pVTA gene expression Nod2 0.03 0.02 5.9e-03 0.03 0.02 0.02 0.02 3.9e-03 5.4e-03 9.8e-03 8.6e-03
5 BLA gene expression Nod2 0.31 0.14 6.1e-12 0.16 0.19 0.19 0.19 5.2e-09 2.9e-10 3.7e-10 2.3e-10
6 IL gene expression Nod2 0.16 0.1 9.9e-04 0.09 0.12 0.09 0.09 3.3e-03 1.1e-03 4.4e-03 3.0e-03
7 OFC alternative polyA XM_063277867.1 0.12 0.09 7.5e-03 0.05 0.03 -0.01 0.02 2.1e-02 7.0e-02 6.1e-01 1.0e-01
8 LHb gene expression Nod2 0.36 0.15 1.7e-07 0.23 0.15 0.2 0.21 2.9e-06 1.8e-04 1.5e-05 9.9e-06
9 Adipose mRNA stability Nod2 0.04 0.03 9.7e-03 -0 -0 -0 -0 6.1e-01 6.4e-01 5.9e-01 4.2e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density2.03.76.62.02.12.62.6-1.6-1.91.61.70.7
Area under the delay curve0.40.60.8-0.9-0.7-0.9-0.90.70.7-0.6-0.8-0.5
BMI with tail2.06.89.9-2.1-2.7-3.1-3.12.22.7-3.0-2.80.4
BMI without tail0.10.71.3-0.4-0.6-1.1-1.10.40.8-0.7-1.00.8
Body weight0.52.04.6-0.6-1.3-2.2-2.20.51.2-1.2-1.31.2
Weight adjusted by age1.23.45.3-1.6-2.1-2.0-2.01.61.9-2.3-2.00.4
Bone surface1.12.33.11.71.61.51.5-1.8-1.31.41.01.5
Bone volume2.55.06.62.62.42.32.3-2.5-2.22.11.91.8
Breakpoint value in progressive ratio session0.30.51.10.20.41.01.0-0.1-0.50.80.6-1.0
Number of licking bursts0.10.40.60.40.50.70.7-0.3-0.60.80.8-0.5
Context. condit. distance diff. score5.06.08.9-2.9-2.6-1.9-1.93.02.6-2.2-2.2-2.4
Locomotion velocity, session 10.40.41.10.31.1-0.1-0.1-0.9-0.70.90.50.2
Locomotion distance, session 10.20.21.3-0.6-0.20.10.10.60.1-0.00.1-1.1
Locomotion velocity, session 20.00.00.2-0.40.3-0.0-0.00.00.10.2-0.1-0.3
Locomotion distance, session 20.30.51.2-0.9-0.7-0.3-0.30.90.6-0.5-0.3-1.1
Locomotion velocity, session 32.12.53.5-1.5-1.7-1.9-1.91.31.6-1.7-1.7-0.1
Locomotion distance, session 30.60.61.0-0.9-0.9-1.0-1.00.80.7-0.7-0.6-0.6
Stereotopy head waving bouts, day 30.81.01.6-1.3-1.0-1.1-1.10.81.1-1.0-1.1-0.2
Stereotopy head waving duration, day 31.11.42.1-1.4-1.1-1.2-1.21.01.3-1.2-1.2-0.4
Locomotion velocity, session 71.92.15.0-1.9-1.6-0.4-0.41.91.4-1.1-1.1-2.2
Locomotion distance, session 70.81.04.3-0.3-0.01.31.30.8-0.10.20.5-2.1
Stereotopy head waving bouts, day 71.31.53.6-1.1-1.1-1.9-1.90.41.1-1.0-1.20.8
Stereotopy head waving duration, day 70.40.52.10.10.2-0.9-0.9-0.9-0.10.2-0.11.4
Locomotion velocity, session 82.02.47.1-1.9-1.5-0.6-0.62.01.4-1.0-1.1-2.7
Locomotion distance, session 82.84.18.1-2.6-2.1-1.2-1.22.62.0-1.5-1.4-2.8
Degree of sensitization distance0.60.72.00.10.41.41.40.3-0.30.30.5-1.2
Degree of sensitization stereotypy1.11.23.0-0.9-0.9-1.7-1.70.30.9-0.8-1.10.8
Conditioned locomotion0.20.20.50.70.60.50.5-0.3-0.50.30.40.5
Cocaine response after cond. corrected1.62.34.7-1.6-1.4-0.8-0.82.21.4-1.5-1.3-2.1
Cocaine response after cond. not corrected0.91.32.3-1.2-1.2-0.9-0.91.51.1-1.2-1.0-1.2
Cocaine response before conditioning2.12.55.31.71.50.60.6-2.3-1.51.61.42.2
Saline control response1.72.45.70.41.12.42.4-0.3-1.01.61.5-1.7
Bone: connectivity density1.93.07.21.61.72.72.7-1.0-1.51.31.40.2
Bone: cortical apparent density0.30.51.8-0.5-0.40.30.31.10.4-0.8-0.3-1.3
Bone: cortical area0.30.50.80.90.70.40.4-0.9-0.60.60.50.8
Bone: cortical porosity0.20.20.6-0.3-0.6-0.8-0.80.00.1-0.2-0.10.3
Bone: cortical porosity0.10.10.20.0-0.2-0.4-0.4-0.2-0.20.10.30.4
Bone: cortical thickness0.10.20.70.70.40.30.3-0.3-0.4-0.00.40.9
Bone: cortical thickness0.20.30.7-0.7-0.40.20.20.70.5-0.3-0.3-0.9
Bone: cortical tissue density0.40.62.1-0.7-0.50.20.21.30.6-0.9-0.4-1.4
Condit. Reinf. active minus inactive responses1.11.22.4-1.5-1.1-0.9-0.91.41.1-1.1-0.8-0.8
Condit. Reinf. active-inactive response ratio1.81.93.6-1.9-1.4-1.3-1.31.51.5-1.2-1.1-0.8
Condit. Reinf. active responses0.00.00.0-0.20.1-0.1-0.1-0.0-0.10.00.20.2
Condit. Reinf. inactive responses3.24.25.52.32.31.91.9-2.2-2.32.02.01.0
Incentive salience index mean0.10.10.4-0.10.30.30.3-0.1-0.30.50.6-0.2
Condit. Reinf. lever presses1.21.72.91.21.51.11.1-1.4-1.51.71.50.3
Condit. Reinf. active minus inactive responses0.10.20.3-0.3-0.4-0.5-0.50.40.3-0.5-0.3-0.1
Condit. Reinf. active-inactive response ratio0.20.31.60.50.1-0.6-0.6-0.3-0.1-0.5-0.21.3
Condit. Reinf. active responses0.20.20.6-0.8-0.4-0.6-0.60.30.4-0.3-0.3-0.5
Condit. Reinf. inactive responses0.71.12.7-1.6-1.0-0.7-0.71.01.0-0.5-0.8-1.5
Condit. Reinf. lever presses0.60.91.2-1.1-1.1-1.1-1.10.81.0-0.9-1.0-0.3
Condit. Reinf. lever reinforcers received0.40.61.1-1.0-0.7-1.0-1.00.50.7-0.7-0.7-0.2
Conditioned reinforcement - actives0.00.00.1-0.1-0.10.20.20.1-0.00.20.1-0.2
Conditioned reinforcement - inactives0.20.40.8-0.9-0.8-0.7-0.70.50.8-0.4-0.60.0
Conditioned locomotion0.00.00.10.10.10.30.3-0.0-0.10.20.1-0.1
Patch foraging indifference point 0 sec0.82.24.8-2.2-1.5-1.3-1.31.51.6-1.1-1.3-1.5
Patch foraging indifference point AUC0.71.62.51.21.41.61.6-1.0-1.41.21.4-0.1
Delay disc. indifference point, 0s delay0.91.01.70.81.20.70.7-1.0-1.21.31.10.3
Delay disc. indifference point, 16s delay0.71.01.3-0.8-1.1-1.1-1.10.91.0-1.1-1.1-0.3
Delay disc. indifference point, 2s delay0.40.40.8-0.4-0.4-0.9-0.90.50.6-0.7-0.90.3
Delay disc. indifference point, 24s delay0.00.00.1-0.2-0.1-0.3-0.30.00.10.0-0.10.1
Delay disc. indifference point, 4s delay0.50.62.8-0.8-0.40.00.01.00.4-0.3-0.3-1.7
Delay disc. indifference point, 8s delay0.91.62.3-1.5-1.3-1.5-1.51.11.2-1.0-1.2-0.6
Indifference point function ln k0.72.02.5-1.4-1.4-1.5-1.51.41.6-1.5-1.6-0.3
Indifference point function log k0.72.02.5-1.4-1.4-1.5-1.51.41.6-1.5-1.6-0.3
Patch foraging total patch changes 0 sec0.92.85.7-2.4-1.7-1.5-1.51.61.8-1.3-1.5-1.5
Patch foraging total patch changes 12 sec0.60.82.5-0.30.51.21.20.1-0.50.70.9-1.6
Patch foraging total patch changes 18 sec0.81.94.20.41.32.02.0-0.7-1.21.31.5-0.8
Patch foraging total patch changes 24 sec0.20.52.1-0.50.30.80.8-0.1-0.40.90.6-1.4
Patch foraging total patch changes 6 sec0.10.20.8-0.6-0.00.30.30.1-0.00.30.3-0.9
Patch foraging time to switch 0 sec0.00.00.1-0.3-0.2-0.1-0.1-0.00.1-0.00.10.3
Patch foraging water rate 0 sec0.00.10.40.50.60.30.3-0.2-0.50.30.3-0.0
Patch foraging water rate 12 sec0.20.71.11.11.10.60.6-0.9-0.90.90.70.7
Patch foraging water rate 18 sec1.84.16.72.62.41.01.0-2.5-2.22.01.62.1
Patch foraging water rate 24 sec0.10.10.20.50.40.20.2-0.2-0.30.20.20.3
Patch foraging water rate 6 sec3.14.56.32.12.52.42.4-2.0-2.22.42.00.4
Seeking ratio, delayed vs. immediate footshock3.95.66.9-2.6-2.6-2.5-2.52.32.6-2.4-2.5-0.7
Distance traveled before self-admin1.12.54.2-1.3-1.6-2.0-2.01.01.6-1.7-1.80.6
Distance traveled after self-admin0.40.74.00.80.2-0.6-0.6-0.9-0.2-0.2-0.22.0
Extensor digitorum longus weight0.41.66.71.81.10.30.3-1.3-1.00.30.72.6
Bone: elastic displacement0.10.10.4-0.0-0.10.50.50.5-0.1-0.20.3-0.7
Bone: elastic work0.00.00.20.40.10.20.2-0.0-0.2-0.00.30.1
Bone: endosteal estimation0.00.10.3-0.3-0.2-0.3-0.30.10.30.0-0.3-0.5
Bone: endosteal perimeter0.20.61.0-1.0-0.8-0.6-0.60.60.9-0.2-0.8-1.0
Epididymis fat weight0.21.11.9-1.2-1.0-1.4-1.40.81.0-0.9-0.9-0.4
Delta time in closed arm before/after self-admin0.40.40.6-0.8-0.7-0.6-0.60.60.7-0.6-0.6-0.2
Delta time in open arm before/after self-admin0.70.81.20.91.01.11.1-0.7-0.90.90.9-0.1
Diff in mean of infusions in LGA sessions0.40.73.8-0.8-0.50.60.61.10.5-0.1-0.1-1.9
Delay discount exponential model param0.40.50.80.90.70.80.8-0.8-0.70.60.80.7
Extinction: sum of active levers before priming2.74.05.4-1.9-2.2-2.1-2.12.12.2-2.2-2.3-0.6
Active lever presses in extinction session 60.10.10.40.40.10.10.1-0.1-0.0-0.10.00.6
Bone: final force1.93.05.42.11.80.90.9-2.3-1.81.61.52.1
Bone: final moment1.32.03.91.71.40.60.6-2.0-1.41.31.21.9
Food consumed during 24 hour testing period3.46.99.22.22.73.03.0-2.5-2.73.02.90.0
Glucose0.20.30.90.40.40.20.2-0.9-0.51.00.40.5
Heart weight1.42.23.0-1.7-1.6-1.2-1.21.51.7-1.2-1.7-1.4
Delay discount hyperbolic model param0.40.50.80.90.70.70.7-0.8-0.70.60.80.7
Intermittent access intake day 1-15 change1.05.57.42.32.42.42.4-2.3-2.52.72.71.1
Intermittent access intake escalation0.84.35.72.12.12.12.1-2.0-2.22.42.31.1
Intermittent access intake escalation 21.52.54.11.31.51.71.7-1.4-1.62.01.90.3
Intermitt. access day 1 inactive lever presses0.00.20.8-0.9-0.3-0.1-0.10.30.4-0.2-0.2-0.8
Intermitt. access day 15 inactive lever presses0.31.42.3-1.5-1.4-0.9-0.91.31.3-1.0-1.0-1.0
Intermitt. access escalation Index0.10.40.7-0.4-0.5-0.6-0.60.90.6-0.5-0.5-0.7
Intermittent access day 1 total infusions0.61.92.7-1.0-1.6-1.5-1.51.31.5-1.6-1.6-0.0
Intermittent access day 15 total infusions0.10.11.00.5-0.1-0.0-0.0-0.1-0.0-0.0-0.01.0
Intermittent access terminal intake (last 3 days)0.10.10.3-0.2-0.5-0.3-0.30.40.4-0.3-0.30.1
Intermittent access total infusions0.00.00.10.2-0.3-0.1-0.10.10.1-0.1-0.10.3
Intermittent access day 1 locomotion0.10.10.70.40.1-0.2-0.2-0.3-0.0-0.3-0.30.8
Intermittent access day 15 total locomotion0.10.31.80.40.1-0.4-0.4-0.5-0.1-0.2-0.21.4
Intermittent access total locomotion0.20.31.60.50.0-0.4-0.4-0.4-0.1-0.1-0.21.3
Intermittent access standard deviation0.21.21.80.91.01.21.2-0.9-1.11.31.30.1
Left kidney weight0.64.66.52.52.31.91.9-2.2-2.42.02.31.5
Right kidney weight0.10.71.20.90.80.30.3-1.0-1.00.91.10.8
Cocaine induced anxiety0.71.93.4-1.8-1.6-0.9-0.91.81.5-1.0-1.0-1.7
Post-drug Anxiety0.91.02.0-1.2-1.1-0.7-0.71.41.1-0.8-0.8-1.1
Baseline Anxiety0.50.81.81.31.00.60.6-1.0-0.90.60.61.2
Tail length0.84.05.62.02.31.91.9-2.3-2.12.42.01.1
Length with tail0.21.12.21.20.90.30.3-1.5-1.01.21.01.2
Length without tail0.10.51.4-0.3-0.7-1.2-1.20.00.5-0.5-0.40.7
Times rat made contact with spout0.30.30.80.60.60.30.3-0.8-0.50.40.30.9
Lifetime Intake0.00.00.10.0-0.3-0.0-0.00.20.10.0-0.0-0.1
Liver weight, left0.00.10.30.00.0-0.1-0.1-0.3-0.20.50.3-0.0
Liver weight, right0.10.20.90.30.2-0.6-0.6-0.5-0.30.10.40.9
Locomotor activity0.20.40.9-0.2-0.6-0.9-0.90.20.5-0.5-0.60.4
Locomotor testing distance0.10.40.5-0.6-0.7-0.7-0.70.50.7-0.6-0.60.0
Locomotor testing rearing0.10.30.7-0.20.20.60.6-0.2-0.30.80.7-0.8
Locomotion in novel chamber0.50.71.3-1.0-0.9-1.2-1.20.70.7-0.8-0.5-0.2
Locomotion in novel chamber post-restriction0.30.91.71.31.10.60.6-1.2-1.11.00.80.8
Fecal boli incidents, locomotor time 10.30.71.10.50.71.11.1-0.5-0.81.01.0-0.3
Change in fecal boli incidents, locomotor task0.20.21.2-0.6-0.20.20.20.60.3-0.2-0.1-1.1
Time >=10cm from walls, locomotor time 10.30.30.90.70.5-0.1-0.1-0.8-0.60.40.31.0
Bouts of movement, locomotor time 10.70.92.30.80.91.51.5-0.6-0.80.80.9-0.0
Total resting periods, locomotor time 10.50.51.70.50.61.31.3-0.3-0.50.50.5-0.0
Rest time, locomotor task time 10.60.91.51.00.91.21.2-0.8-0.80.60.71.1
Distance moved, locomotor task time 10.31.02.1-1.2-1.0-0.8-0.81.00.9-0.7-0.8-1.4
Vertical activity count, locomotor time 10.00.30.70.50.50.30.3-0.6-0.70.80.8-0.1
Time >=10cm from walls, locomotor time 20.10.31.20.1-0.0-0.9-0.9-0.20.2-0.4-0.41.1
Bouts of movement, locomotor time 20.00.10.2-0.2-0.10.10.10.40.2-0.4-0.2-0.2
Total resting periods, locomotor time 20.00.10.2-0.10.00.50.50.40.1-0.2-0.1-0.5
Rest time, locomotor task time 20.40.62.40.50.21.51.50.2-0.20.20.3-0.4
Distance moved, locomotor task time 21.31.83.8-1.3-1.3-2.0-2.00.81.1-1.2-1.2-0.1
Vertical activity count, locomotor time 20.10.20.4-0.10.2-0.5-0.5-0.5-0.40.50.70.1
Light reinforcement 15.022.628.14.55.25.15.1-4.5-5.25.35.30.9
Light reinforcement 25.913.216.33.74.03.93.9-3.6-3.94.03.71.2
Bone: marrow area0.00.10.3-0.4-0.3-0.4-0.40.10.4-0.0-0.4-0.5
Bone: maximum diameter0.30.51.0-0.6-0.8-1.0-1.00.40.8-0.5-0.9-0.1
Bone: maximum force0.40.71.41.10.80.60.6-1.2-0.80.70.61.1
Bone: maximum moment0.20.30.80.80.40.30.3-0.9-0.50.40.30.9
Mean time between licks in bursts0.10.71.2-0.9-1.1-1.1-1.10.90.7-0.5-0.6-0.3
Mean num. licks in bursts0.10.21.00.10.0-0.3-0.3-0.20.2-0.5-0.51.0
Cd content in liver2.52.85.9-2.1-1.5-0.7-0.72.31.6-1.6-1.2-2.4
Co content in liver1.71.92.6-1.6-1.6-1.4-1.41.51.4-1.4-1.3-0.9
Cu content in liver0.10.10.20.20.2-0.3-0.3-0.3-0.20.00.20.5
Fe content in liver4.25.211.32.72.41.11.1-3.0-2.21.81.83.4
K content in liver0.70.71.60.0-0.6-1.2-1.20.00.4-0.8-0.51.3
Mg content in liver0.60.61.2-0.5-0.8-1.1-1.10.50.7-0.9-0.60.7
Mn content in liver1.21.33.0-1.2-1.3-0.3-0.31.71.1-1.3-0.8-1.3
Na content in liver0.81.04.61.10.6-0.4-0.4-1.3-0.60.40.22.1
Rb content in liver0.70.81.30.70.90.80.8-1.1-1.00.91.20.9
Se content in liver3.23.86.62.22.11.01.0-2.5-2.01.51.82.6
Sr content in liver0.40.40.8-0.5-0.6-0.9-0.90.40.5-0.5-0.60.1
Zn content in liver1.92.22.8-1.6-1.4-1.5-1.51.51.6-1.7-1.7-0.3
Bone: minimum diameter1.12.02.81.71.61.31.3-1.6-1.51.41.40.8
Time in familiar zone, hab. session 10.50.50.80.60.90.50.5-0.8-0.90.90.90.2
Time in novel zone, hab. session 10.30.30.8-0.0-0.5-0.3-0.30.50.6-0.9-0.70.5
Total zone transitions, hab. session 10.30.40.6-0.8-0.6-0.5-0.50.60.6-0.4-0.6-0.5
Total locomotion distance, hab. session 10.50.71.2-1.0-0.8-0.4-0.41.10.9-0.9-0.8-0.7
Locomotion velocity, hab. session 10.50.71.3-1.1-0.8-0.5-0.51.10.9-0.8-0.8-0.9
Time in familiar zone, hab. session 20.91.01.60.51.01.31.3-0.5-0.91.21.1-0.8
Time in novel zone, hab. session 22.02.24.1-1.0-1.5-1.5-1.51.31.5-2.0-1.70.6
Total zone transitions, hab. session 20.10.10.7-0.6-0.20.10.10.20.20.20.0-0.8
Total locomotion distance, hab. session 20.10.20.5-0.5-0.20.10.10.60.3-0.3-0.2-0.7
Locomotion velocity, hab. session 20.00.00.1-0.20.20.30.30.2-0.00.00.1-0.4
Novel to familiar place preference ratio0.70.91.4-0.7-1.2-0.9-0.90.91.0-1.2-1.20.0
Novelty place preference0.50.61.0-0.5-1.0-0.7-0.70.70.9-1.0-1.00.1
Time in novel zone, NPP test0.50.61.0-0.3-0.9-0.9-0.90.40.8-0.9-1.00.6
Total zone transitions, NPP test0.00.10.2-0.4-0.1-0.3-0.30.30.2-0.2-0.0-0.2
Total locomotion distance, NPP test0.10.10.3-0.2-0.1-0.4-0.40.30.3-0.5-0.30.5
Locomotion velocity, NPP test0.00.00.1-0.20.0-0.0-0.00.20.1-0.30.00.1
Intraocular pressure4.16.69.0-2.8-2.6-2.2-2.23.02.8-2.7-2.7-1.8
Delta distance traveled before/after self-admin2.83.14.72.21.91.51.5-2.0-2.01.71.71.3
Delta ambulatory time before/after self-admin2.64.55.72.42.32.02.0-2.2-2.42.12.31.2
Parametrial fat weight0.20.41.7-0.8-0.6-0.1-0.10.70.40.10.0-1.3
Pavlov. Cond. lever latency0.10.20.8-0.3-0.40.10.10.50.3-0.1-0.2-0.9
Pavlov. Cond. magazine entry latency0.10.10.90.30.1-0.2-0.2-0.2-0.0-0.20.01.0
Pavlov. Cond. change in total contacts1.71.84.31.51.50.60.6-1.7-1.21.11.02.1
Pavlov. Cond. index score0.10.20.90.0-0.1-0.5-0.5-0.10.1-0.3-0.11.0
Pavlov. Cond. latency score0.10.10.4-0.0-0.1-0.3-0.30.00.1-0.3-0.10.6
Pavlov. Cond. lever contacts0.20.21.40.20.3-0.4-0.4-0.4-0.1-0.00.01.2
Pavlov. Cond. magazine entry number0.50.63.5-0.3-0.10.80.80.60.00.20.1-1.9
Pavlov. Cond. intertrial magazine entries0.20.30.7-0.6-0.4-0.3-0.30.90.3-0.6-0.3-0.8
Pavlov. Cond. lever-magazine prob. diff.0.20.30.9-0.0-0.2-0.7-0.70.00.3-0.5-0.31.0
Pavlov. Cond. response bias0.60.74.10.50.5-0.6-0.6-0.8-0.3-0.10.02.0
Pavlov. Cond. lever latency0.10.20.5-0.2-0.30.10.10.60.4-0.7-0.4-0.3
Pavlov. Cond. magazine entry latency0.00.10.1-0.2-0.1-0.4-0.4-0.0-0.00.30.1-0.3
Pavlov. Cond. change in total contacts0.10.10.5-0.2-0.0-0.7-0.7-0.3-0.00.20.00.5
Pavlov. Cond. index score0.10.10.3-0.1-0.1-0.6-0.6-0.3-0.00.30.10.4
Pavlov. Cond. latency score0.00.10.20.10.0-0.4-0.4-0.3-0.10.30.20.4
Pavlov. Cond. lever contacts0.20.40.90.40.60.10.1-0.9-0.71.00.70.4
Pavlov. Cond. magazine entry number0.10.10.30.10.20.60.60.1-0.1-0.00.1-0.3
Pavlov. Cond. intertrial magazine entries0.40.91.80.81.01.31.3-0.6-0.90.81.1-0.2
Pavlov. Cond. lever-magazine prob. diff.0.10.10.4-0.1-0.1-0.6-0.6-0.3-0.00.30.00.4
Pavlov. Cond. response bias0.10.20.30.00.1-0.5-0.5-0.6-0.20.60.20.5
Time in closed arm before self-admin2.33.95.42.32.21.61.6-2.3-2.22.12.01.3
Time in closed arm after self-admin1.31.52.01.41.41.01.0-1.4-1.31.21.20.7
Time in open arm before self-admin1.82.23.5-1.9-1.7-1.4-1.41.51.6-1.4-1.4-0.9
Time in open arm after self-admin0.91.01.2-1.1-1.1-1.1-1.10.91.0-1.1-1.1-0.1
Bone: periosteal estimation0.10.10.30.50.40.20.2-0.5-0.30.50.20.2
Bone: periosteal perimeter0.20.30.5-0.6-0.6-0.5-0.50.50.7-0.2-0.7-0.6
Bone: post-yield work0.10.10.7-0.4-0.4-0.1-0.1-0.00.60.1-0.8-0.1
Progressive ratio test 1 active lever presses0.10.21.30.60.1-0.1-0.1-0.5-0.2-0.0-0.11.2
Progressive ratio test 1 breakpoint0.10.21.40.60.1-0.2-0.2-0.5-0.2-0.0-0.11.2
Progressive ratio test 1 inactive lever presses0.00.10.3-0.2-0.4-0.4-0.4-0.00.3-0.3-0.30.5
Progressive ratio test 2 active lever presses0.10.10.50.3-0.2-0.1-0.1-0.10.0-0.2-0.20.7
Progressive ratio test 2 breakpoint0.10.10.30.2-0.3-0.1-0.10.00.1-0.3-0.30.6
Progressive ratio test 2 inactive lever presses0.51.52.2-1.4-1.5-1.1-1.11.41.4-1.2-1.3-0.6
Incentive Sensitization - Responses0.00.10.2-0.2-0.30.20.20.40.2-0.1-0.0-0.4
Incentive Sensitization - Breakpoint0.00.10.2-0.2-0.30.30.30.30.1-0.10.0-0.4
Sum of active levers in priming session hrs 5-60.20.20.4-0.4-0.5-0.0-0.00.60.5-0.4-0.4-0.5
Progressive ratio0.10.41.10.60.71.01.0-0.4-0.50.60.40.1
Food seeking constrained by brief footshock1.92.43.91.21.61.81.8-1.3-1.62.01.6-0.3
Seeking ratio, punishment vs. effort0.40.91.50.90.90.50.5-1.2-1.11.21.20.4
Retroperitoneal fat weight0.52.34.5-1.9-1.6-0.8-0.82.01.4-1.2-0.9-2.1
Reaction time number correct0.30.91.5-0.9-1.0-1.0-1.01.11.0-1.2-0.9-0.1
Reaction time mean minus median0.21.32.5-0.6-0.8-1.5-1.50.10.9-1.1-1.21.6
Reaction time mean minus median AUC0.21.22.0-0.7-0.9-1.4-1.40.31.0-1.2-1.21.4
Reaction time num false alarms4.78.012.0-3.5-3.0-2.9-2.92.92.9-2.6-2.7-1.8
Reaction time num false alarms AUC3.17.010.9-3.3-2.8-2.7-2.72.72.8-2.4-2.5-1.8
Reaction time trials correct on left0.30.91.5-0.9-1.0-1.0-1.01.11.0-1.2-0.9-0.1
Reaction time trials on left0.31.11.8-1.0-1.1-1.1-1.11.21.1-1.3-1.0-0.1
Reaction time mean1.22.64.4-1.0-1.5-2.1-2.10.91.5-2.0-1.81.1
Reaction time mean AUC1.12.74.5-1.1-1.5-2.1-2.11.01.6-2.0-1.81.0
Median of all reaction times1.42.23.7-0.9-1.4-1.9-1.91.01.4-1.9-1.70.8
Reaction time omissions2.13.45.3-1.8-2.0-2.3-2.31.41.8-1.9-1.80.1
Reaction time false alarm rate2.33.25.3-2.3-1.9-1.8-1.81.81.8-1.4-1.6-1.5
Reaction time premature initiation rate2.43.75.91.21.72.42.4-1.1-1.92.42.2-1.5
Reaction time premature initiations0.51.52.50.60.91.61.6-0.4-1.01.41.4-1.4
Std. dev. reaction times0.51.52.8-0.9-1.0-1.7-1.70.41.1-1.3-1.31.2
Reaction time trials completed0.31.11.8-1.0-1.1-1.1-1.11.21.1-1.3-1.0-0.1
Reaction time trials AUC0.31.21.9-1.0-1.1-1.1-1.11.31.1-1.4-1.1-0.1
Run reversals in cocaine runway, females0.30.40.9-0.5-0.5-0.9-0.90.20.5-0.5-0.60.5
Run reversals in cocaine runway, males0.10.10.50.1-0.3-0.2-0.20.30.2-0.5-0.20.7
Latency to leave start box in cocaine runway0.30.40.8-0.8-0.5-0.3-0.30.90.7-0.6-0.6-0.7
Latency to leave start box in cocaine runway, F0.40.41.0-0.3-0.5-0.6-0.60.60.8-1.0-0.90.4
Latency to leave start box in cocaine runway, M0.60.63.5-0.80.10.50.50.5-0.00.50.4-1.9
Std. dev. time between licks in bursts0.10.20.40.50.30.40.4-0.0-0.50.30.7-0.1
Total sessions with >9 infusions0.00.00.10.2-0.1-0.1-0.1-0.0-0.0-0.1-0.10.3
Short access day 1 total inactive lever presses0.10.21.00.60.20.10.1-0.4-0.30.20.21.0
Short access day 10 total inactive lever presses0.00.20.40.10.30.40.4-0.2-0.40.60.6-0.5
Short access day 1 total infusions0.40.70.9-0.8-0.9-0.9-0.90.80.9-0.9-0.9-0.2
Short access day 10 total infusions0.00.00.10.0-0.20.30.30.20.00.00.1-0.4
Short access total infusions0.00.10.2-0.2-0.4-0.2-0.20.40.3-0.2-0.3-0.1
Short access day 1 locomotion1.32.12.7-1.6-1.5-1.4-1.41.41.5-1.6-1.6-0.6
Short access day 10 total locomotion0.00.10.2-0.1-0.2-0.3-0.30.10.2-0.3-0.40.2
Short access total locomotion0.30.40.7-0.7-0.7-0.6-0.60.70.7-0.7-0.8-0.3
One hour access (0.3 mA shock)0.80.92.0-1.2-1.1-0.3-0.31.21.0-0.5-0.6-1.4
Compulsive drug intake0.10.20.6-0.6-0.30.10.10.50.5-0.1-0.2-0.7
One hour access (shock baseline)0.10.40.6-0.7-0.8-0.3-0.30.80.6-0.4-0.5-0.8
Social response proportion0.10.10.40.50.1-0.2-0.2-0.0-0.2-0.30.30.7
Social responses0.50.72.7-1.1-0.8-0.4-0.41.10.6-0.4-0.2-1.6
Social time0.91.42.11.31.21.51.5-0.8-1.30.91.40.1
Soleus weight0.10.30.9-0.4-0.8-0.1-0.10.60.5-0.2-0.5-0.9
Bone: stiffness0.30.62.30.80.5-0.1-0.1-1.1-0.50.50.11.5
Tibialis anterior weight0.31.21.7-0.5-0.9-1.3-1.30.61.1-1.3-1.21.2
Time to tail flick, vehicle, before self-admin0.30.42.2-0.5-0.10.50.50.60.2-0.0-0.2-1.5
Time to tail flick, vehicle, after self-admin0.30.71.80.10.41.31.3-0.1-0.40.80.6-1.3
Time to tail flick, test, before self-admin1.11.31.8-1.2-1.1-0.9-0.91.31.2-1.1-1.3-1.1
Time to tail flick, test, after self-admin1.11.21.81.31.20.90.9-1.4-1.11.00.81.0
Delta time to tail flick, vehicle, before/after SA0.20.20.40.30.40.60.6-0.3-0.40.60.5-0.1
Delta time to tail flick, test, before/after SA2.32.86.72.11.60.70.7-2.3-1.61.31.22.6
Tibia length0.61.78.00.7-0.0-1.5-1.5-1.40.00.1-0.62.8
Ambulatory time before self-admin1.03.14.7-1.5-1.8-2.2-2.21.31.8-1.9-2.00.3
Ambulatory time after self-admin0.61.03.21.30.90.20.2-1.3-0.90.50.61.8
Bone: tissue strength0.10.10.40.60.10.10.1-0.2-0.4-0.00.40.6
Total heroin consumption0.20.30.5-0.6-0.7-0.5-0.50.60.6-0.4-0.5-0.3
Bone: trabecular number1.93.77.32.01.92.72.7-1.5-1.81.41.70.7
Bone: trabecular spacing1.21.82.7-1.2-1.4-1.6-1.61.51.2-1.4-0.9-0.8
Bone: trabecular thickness3.95.47.82.82.52.42.4-2.5-2.42.02.01.8
Bone: trabecular tissue density0.40.61.0-0.8-0.7-1.0-1.00.80.8-0.8-0.9-0.3
Water consumed over 24 hours1.63.13.91.81.81.81.8-1.9-1.92.01.80.6
Number of responses in last shaping day1.92.54.0-2.0-1.7-1.3-1.31.71.6-1.4-1.5-1.5