Hub : Genes

Nod2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Nod2 0.18 0.11 6.0e-13 0.1 0.11 0.11 0.11 3.9e-11 5.5e-12 1.9e-12 2.8e-12
2 Brain gene expression Nod2 0.22 0.1 0.0e+00 0.28 0.29 0.3 0.3 1.0e-26 1.4e-27 3.0e-28 3.8e-28
3 Adipose gene expression Nod2 0.02 0.02 2.8e-03 0.01 0 0.01 0 6.7e-03 1.4e-01 4.6e-02 1.1e-01
4 pVTA gene expression Nod2 0.03 0.02 5.9e-03 0.03 0.02 0.02 0.02 3.9e-03 5.4e-03 9.8e-03 9.4e-03
5 BLA gene expression Nod2 0.31 0.14 6.1e-12 0.16 0.19 0.19 0.19 5.2e-09 2.9e-10 3.7e-10 2.3e-10
6 IL gene expression Nod2 0.16 0.1 9.9e-04 0.09 0.12 0.09 0.1 3.3e-03 1.1e-03 4.4e-03 2.8e-03
7 OFC alternative polyA XM_063277867.1 0.12 0.09 7.5e-03 0.05 0.03 -0.01 0.02 2.1e-02 7.0e-02 6.1e-01 1.1e-01
8 LHb gene expression Nod2 0.36 0.15 1.7e-07 0.23 0.15 0.2 0.21 2.9e-06 1.8e-04 1.5e-05 9.7e-06
9 Adipose mRNA stability Nod2 0.04 0.03 9.7e-03 -0 -0 -0 -0 6.1e-01 6.4e-01 5.9e-01 4.3e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density2.23.76.6-2.0-2.1-2.6-2.6-1.6-1.9-1.6-1.70.7
Area under the delay curve0.50.60.80.90.70.90.90.70.70.60.8-0.5
BMI with tail2.06.89.92.12.73.13.12.22.73.02.80.4
BMI without tail0.20.71.30.40.61.11.10.40.80.71.00.8
Body weight0.52.04.60.61.32.22.20.51.21.21.31.2
Weight adjusted by age2.23.45.31.62.12.02.01.61.92.32.00.4
Bone surface1.22.33.1-1.7-1.6-1.5-1.5-1.8-1.3-1.4-1.01.5
Bone volume2.85.06.6-2.6-2.4-2.3-2.3-2.5-2.2-2.1-1.91.8
Breakpoint value in progressive ratio session0.40.51.1-0.2-0.4-1.0-1.0-0.1-0.5-0.8-0.6-1.0
Number of licking bursts0.20.40.6-0.4-0.5-0.7-0.7-0.3-0.6-0.8-0.8-0.5
Context. condit. distance diff. score5.06.08.92.92.61.91.93.02.62.22.2-2.4
Locomotion velocity, session 10.40.41.1-0.3-1.10.10.1-0.9-0.7-0.9-0.50.2
Locomotion distance, session 10.20.21.30.60.2-0.1-0.10.60.10.0-0.1-1.1
Locomotion velocity, session 20.00.00.20.4-0.30.00.00.00.1-0.20.1-0.3
Locomotion distance, session 20.30.51.20.90.70.30.30.90.60.50.3-1.1
Locomotion velocity, session 32.22.53.51.51.71.91.91.31.61.71.7-0.0
Locomotion distance, session 30.60.61.00.90.91.01.00.80.70.70.6-0.6
Stereotopy head waving bouts, day 30.91.01.61.31.01.11.10.81.11.01.1-0.2
Stereotopy head waving duration, day 31.21.42.11.41.11.21.21.01.31.21.2-0.4
Locomotion velocity, session 72.02.15.01.91.60.40.41.91.41.11.1-2.2
Locomotion distance, session 70.81.04.30.30.0-1.3-1.30.8-0.1-0.2-0.5-2.1
Stereotopy head waving bouts, day 71.41.53.61.11.11.91.90.41.11.01.20.8
Stereotopy head waving duration, day 70.40.52.1-0.1-0.20.90.9-0.9-0.1-0.20.11.5
Locomotion velocity, session 82.02.47.11.91.50.60.62.01.41.01.1-2.7
Locomotion distance, session 82.94.18.12.62.11.21.22.62.01.51.4-2.8
Degree of sensitization distance0.60.72.0-0.1-0.4-1.4-1.40.3-0.3-0.3-0.5-1.2
Degree of sensitization stereotypy1.11.23.00.90.91.71.70.30.90.81.10.8
Conditioned locomotion0.20.20.5-0.7-0.6-0.5-0.5-0.3-0.5-0.3-0.40.5
Cocaine response after cond. corrected1.92.34.71.61.40.80.82.21.41.51.3-2.1
Cocaine response after cond. not corrected1.11.32.31.21.20.90.91.51.11.21.0-1.2
Cocaine response before conditioning2.12.55.3-1.7-1.5-0.6-0.6-2.3-1.5-1.6-1.42.2
Saline control response1.82.45.7-0.4-1.1-2.4-2.4-0.3-1.0-1.6-1.5-1.7
Bone: connectivity density1.93.07.2-1.6-1.7-2.7-2.7-1.0-1.5-1.3-1.40.2
Bone: cortical apparent density0.40.51.80.50.4-0.3-0.31.10.40.80.3-1.3
Bone: cortical area0.30.50.8-0.9-0.7-0.4-0.4-0.9-0.6-0.6-0.50.9
Bone: cortical porosity0.20.20.60.30.60.80.80.00.10.20.10.3
Bone: cortical porosity0.10.10.2-0.00.20.40.4-0.2-0.2-0.1-0.30.4
Bone: cortical thickness0.10.20.7-0.7-0.4-0.3-0.3-0.3-0.40.0-0.40.9
Bone: cortical thickness0.20.30.70.70.4-0.2-0.20.70.50.30.3-0.9
Bone: cortical tissue density0.50.62.10.70.6-0.2-0.21.30.60.90.4-1.4
Condit. Reinf. active minus inactive responses1.11.22.41.51.10.90.91.41.11.10.8-0.8
Condit. Reinf. active-inactive response ratio1.81.93.61.91.41.31.31.51.51.21.1-0.8
Condit. Reinf. active responses0.00.00.00.2-0.10.10.1-0.0-0.1-0.0-0.20.2
Condit. Reinf. inactive responses3.44.25.5-2.3-2.3-1.9-1.9-2.2-2.3-2.0-2.01.0
Incentive salience index mean0.10.10.40.1-0.3-0.3-0.3-0.1-0.3-0.5-0.6-0.2
Condit. Reinf. lever presses1.21.72.9-1.2-1.5-1.1-1.1-1.4-1.5-1.7-1.50.3
Condit. Reinf. active minus inactive responses0.10.20.30.30.40.50.50.40.30.50.3-0.1
Condit. Reinf. active-inactive response ratio0.30.31.6-0.5-0.10.60.6-0.3-0.10.50.21.3
Condit. Reinf. active responses0.20.20.60.80.40.60.60.30.40.30.3-0.4
Condit. Reinf. inactive responses0.81.12.71.61.00.70.71.01.00.50.8-1.5
Condit. Reinf. lever presses0.70.91.21.11.11.11.10.81.00.91.0-0.3
Condit. Reinf. lever reinforcers received0.40.61.11.00.71.01.00.50.70.70.7-0.2
Conditioned reinforcement - actives0.00.00.10.10.1-0.2-0.20.1-0.0-0.2-0.1-0.2
Conditioned reinforcement - inactives0.30.40.80.90.80.70.70.50.80.40.60.0
Conditioned locomotion0.00.00.1-0.1-0.1-0.3-0.3-0.0-0.1-0.2-0.1-0.1
Patch foraging indifference point 0 sec1.22.24.82.21.51.31.31.51.61.11.3-1.5
Patch foraging indifference point AUC1.11.62.5-1.2-1.4-1.6-1.6-1.0-1.4-1.2-1.4-0.1
Delay disc. indifference point, 0s delay0.91.01.7-0.8-1.2-0.7-0.7-1.0-1.2-1.3-1.10.3
Delay disc. indifference point, 16s delay0.90.91.30.81.11.11.10.91.01.11.1-0.3
Delay disc. indifference point, 2s delay0.40.40.80.40.40.90.90.50.60.70.90.3
Delay disc. indifference point, 24s delay0.00.00.10.20.10.30.30.10.1-0.00.10.1
Delay disc. indifference point, 4s delay0.50.62.90.80.4-0.0-0.01.00.40.30.3-1.7
Delay disc. indifference point, 8s delay1.31.62.31.51.31.51.51.11.21.01.2-0.6
Indifference point function ln k1.12.02.51.41.41.51.51.41.61.51.6-0.3
Indifference point function log k1.12.02.51.41.41.51.51.41.61.51.6-0.3
Patch foraging total patch changes 0 sec1.52.85.72.41.71.51.51.61.81.31.5-1.5
Patch foraging total patch changes 12 sec0.60.82.50.3-0.5-1.2-1.20.1-0.5-0.7-0.9-1.6
Patch foraging total patch changes 18 sec1.21.94.2-0.4-1.3-2.0-2.0-0.7-1.2-1.3-1.5-0.8
Patch foraging total patch changes 24 sec0.30.52.00.5-0.3-0.8-0.8-0.1-0.4-0.9-0.6-1.4
Patch foraging total patch changes 6 sec0.10.20.80.60.0-0.3-0.30.1-0.0-0.3-0.3-0.9
Patch foraging time to switch 0 sec0.00.00.10.30.20.10.1-0.00.10.0-0.10.3
Patch foraging water rate 0 sec0.10.10.4-0.5-0.6-0.3-0.3-0.2-0.5-0.3-0.3-0.1
Patch foraging water rate 12 sec0.30.71.1-1.1-1.1-0.6-0.6-0.9-0.9-0.9-0.70.6
Patch foraging water rate 18 sec2.64.16.7-2.6-2.4-1.0-1.0-2.5-2.2-2.0-1.62.0
Patch foraging water rate 24 sec0.10.10.2-0.5-0.4-0.2-0.2-0.2-0.3-0.2-0.20.3
Patch foraging water rate 6 sec3.14.56.3-2.1-2.5-2.4-2.4-1.9-2.2-2.4-2.00.3
Seeking ratio, delayed vs. immediate footshock4.65.66.92.62.62.52.52.32.62.42.5-0.7
Distance traveled before self-admin1.92.54.21.31.62.02.01.01.61.71.80.6
Distance traveled after self-admin0.60.74.0-0.8-0.20.60.6-0.9-0.20.20.22.0
Extensor digitorum longus weight0.41.66.7-1.8-1.1-0.3-0.3-1.3-1.0-0.3-0.72.6
Bone: elastic displacement0.10.10.50.00.1-0.5-0.50.5-0.10.2-0.3-0.7
Bone: elastic work0.00.00.2-0.4-0.1-0.2-0.2-0.0-0.20.0-0.30.1
Bone: endosteal estimation0.00.10.30.30.20.30.30.10.3-0.00.3-0.5
Bone: endosteal perimeter0.30.60.91.00.80.60.60.60.90.20.8-1.0
Epididymis fat weight0.31.11.91.21.01.41.40.81.00.90.9-0.4
Delta time in closed arm before/after self-admin0.40.40.60.80.70.60.60.60.70.60.6-0.2
Delta time in open arm before/after self-admin0.80.81.2-0.9-1.0-1.1-1.1-0.7-0.9-0.9-0.9-0.1
Diff in mean of infusions in LGA sessions0.60.73.80.80.5-0.6-0.61.10.50.10.1-1.9
Delay discount exponential model param0.50.50.8-0.9-0.7-0.8-0.8-0.8-0.7-0.6-0.80.7
Extinction: sum of active levers before priming3.74.05.41.92.22.12.12.12.22.22.3-0.6
Active lever presses in extinction session 60.10.10.3-0.4-0.1-0.1-0.1-0.1-0.00.1-0.00.6
Bone: final force1.93.05.5-2.1-1.8-0.9-0.9-2.3-1.8-1.6-1.52.1
Bone: final moment1.32.13.9-1.7-1.4-0.6-0.6-2.0-1.4-1.3-1.21.9
Food consumed during 24 hour testing period5.06.99.2-2.2-2.7-3.0-3.0-2.5-2.7-3.0-2.90.0
Glucose0.20.30.9-0.4-0.4-0.2-0.2-0.9-0.5-1.0-0.40.5
Heart weight1.42.23.01.71.61.21.21.51.71.21.7-1.4
Delay discount hyperbolic model param0.50.50.8-0.9-0.7-0.7-0.7-0.8-0.7-0.6-0.80.7
Intermittent access intake day 1-15 change2.75.57.4-2.3-2.4-2.4-2.4-2.3-2.5-2.7-2.71.1
Intermittent access intake escalation2.14.35.7-2.1-2.1-2.1-2.1-2.0-2.2-2.4-2.31.1
Intermittent access intake escalation 22.12.54.1-1.3-1.5-1.7-1.7-1.4-1.6-2.0-1.90.3
Intermitt. access day 1 inactive lever presses0.10.20.80.90.30.10.10.30.40.20.2-0.8
Intermitt. access day 15 inactive lever presses0.71.42.31.51.40.90.91.31.31.01.0-1.0
Intermitt. access escalation Index0.30.40.70.40.50.60.60.90.60.50.5-0.7
Intermittent access day 1 total infusions1.21.92.71.01.61.51.51.31.51.61.6-0.0
Intermittent access day 15 total infusions0.10.11.0-0.50.10.00.0-0.2-0.00.00.01.0
Intermittent access terminal intake (last 3 days)0.10.10.30.20.50.30.30.40.40.30.30.1
Intermittent access total infusions0.00.00.1-0.20.30.10.10.10.10.10.10.3
Intermittent access day 1 locomotion0.10.10.6-0.4-0.10.20.2-0.3-0.00.30.30.8
Intermittent access day 15 total locomotion0.20.31.8-0.4-0.20.40.4-0.5-0.10.20.21.4
Intermittent access total locomotion0.20.31.6-0.5-0.10.40.4-0.4-0.10.10.21.3
Intermittent access standard deviation0.61.21.8-0.9-1.0-1.2-1.2-0.9-1.1-1.3-1.30.1
Left kidney weight1.04.66.5-2.5-2.3-1.9-1.9-2.2-2.4-2.0-2.31.5
Right kidney weight0.20.71.2-0.9-0.8-0.3-0.3-1.0-1.0-0.9-1.10.8
Cocaine induced anxiety1.41.93.41.81.60.90.91.81.51.01.0-1.7
Post-drug Anxiety1.01.02.01.21.10.70.71.41.10.80.8-1.1
Baseline Anxiety0.70.81.8-1.3-1.0-0.6-0.6-1.0-0.9-0.6-0.61.2
Tail length1.04.05.6-2.0-2.3-1.9-1.9-2.2-2.1-2.4-2.01.1
Length with tail0.21.12.3-1.2-0.9-0.3-0.3-1.5-1.0-1.2-1.01.2
Length without tail0.20.51.40.30.71.21.2-0.00.50.50.40.8
Times rat made contact with spout0.30.30.8-0.6-0.6-0.3-0.3-0.8-0.5-0.4-0.30.9
Lifetime Intake0.00.00.1-0.00.30.00.00.20.1-0.00.0-0.1
Liver weight, left0.00.10.3-0.0-0.00.10.1-0.3-0.2-0.5-0.3-0.0
Liver weight, right0.10.20.9-0.3-0.20.60.6-0.5-0.3-0.1-0.40.9
Locomotor activity0.20.40.90.20.60.90.90.20.50.50.60.4
Locomotor testing distance0.20.40.50.60.70.70.70.50.70.60.60.0
Locomotor testing rearing0.10.30.70.2-0.2-0.6-0.6-0.2-0.3-0.8-0.7-0.8
Locomotion in novel chamber0.60.71.31.00.91.21.20.70.70.80.5-0.2
Locomotion in novel chamber post-restriction0.60.91.7-1.3-1.1-0.6-0.6-1.2-1.1-1.0-0.80.8
Fecal boli incidents, locomotor time 10.50.71.1-0.5-0.7-1.1-1.1-0.5-0.8-1.0-1.0-0.3
Change in fecal boli incidents, locomotor task0.20.21.20.60.2-0.2-0.20.60.30.20.1-1.1
Time >=10cm from walls, locomotor time 10.30.30.9-0.7-0.50.10.1-0.8-0.6-0.4-0.31.0
Bouts of movement, locomotor time 10.80.92.3-0.8-0.9-1.5-1.5-0.6-0.8-0.8-0.9-0.0
Total resting periods, locomotor time 10.50.51.7-0.5-0.6-1.3-1.3-0.3-0.5-0.5-0.5-0.0
Rest time, locomotor task time 10.70.91.5-1.0-0.9-1.2-1.2-0.8-0.8-0.6-0.71.1
Distance moved, locomotor task time 10.61.02.11.21.00.80.81.00.90.70.8-1.4
Vertical activity count, locomotor time 10.10.30.7-0.5-0.5-0.3-0.3-0.6-0.7-0.8-0.8-0.1
Time >=10cm from walls, locomotor time 20.20.31.2-0.10.00.90.9-0.20.20.40.41.1
Bouts of movement, locomotor time 20.00.10.20.20.1-0.1-0.10.40.20.40.2-0.2
Total resting periods, locomotor time 20.10.10.20.1-0.0-0.5-0.50.40.10.20.1-0.5
Rest time, locomotor task time 20.50.62.4-0.5-0.2-1.5-1.50.2-0.2-0.2-0.3-0.4
Distance moved, locomotor task time 21.51.73.81.31.22.02.00.81.11.21.2-0.1
Vertical activity count, locomotor time 20.10.20.40.1-0.20.50.5-0.5-0.4-0.5-0.70.1
Light reinforcement 19.222.528.1-4.5-5.2-5.1-5.1-4.5-5.2-5.3-5.30.9
Light reinforcement 28.613.216.3-3.7-4.0-3.9-3.9-3.6-3.9-4.0-3.71.2
Bone: marrow area0.10.10.30.40.30.40.40.10.40.00.4-0.5
Bone: maximum diameter0.30.51.00.60.81.01.00.40.80.50.9-0.1
Bone: maximum force0.40.71.4-1.1-0.8-0.6-0.6-1.2-0.8-0.7-0.61.1
Bone: maximum moment0.20.30.8-0.8-0.4-0.3-0.3-0.9-0.5-0.4-0.30.9
Mean time between licks in bursts0.30.71.20.91.11.11.10.90.70.50.6-0.4
Mean num. licks in bursts0.10.21.0-0.1-0.00.30.3-0.20.20.50.51.0
Cd content in liver2.52.85.92.11.50.70.72.31.61.61.2-2.4
Co content in liver1.71.92.61.61.61.41.41.51.41.41.3-0.9
Cu content in liver0.10.10.2-0.2-0.20.30.3-0.3-0.2-0.0-0.20.5
Fe content in liver4.35.211.3-2.7-2.4-1.1-1.1-3.0-2.2-1.8-1.83.4
K content in liver0.70.71.7-0.00.51.21.20.00.40.80.51.3
Mg content in liver0.60.61.20.50.81.11.10.50.70.90.60.7
Mn content in liver1.21.33.01.21.30.30.31.71.11.30.8-1.3
Na content in liver0.91.04.6-1.1-0.60.40.4-1.3-0.6-0.4-0.22.1
Rb content in liver0.70.81.3-0.7-0.9-0.8-0.8-1.1-1.0-0.9-1.20.9
Se content in liver3.23.86.6-2.2-2.1-1.0-1.0-2.5-2.0-1.5-1.82.6
Sr content in liver0.40.40.80.50.60.90.90.40.50.50.60.1
Zn content in liver2.02.22.81.61.41.51.51.51.61.71.7-0.3
Bone: minimum diameter1.12.02.8-1.7-1.6-1.3-1.3-1.6-1.5-1.4-1.40.8
Time in familiar zone, hab. session 10.50.50.8-0.6-0.9-0.5-0.5-0.8-0.9-0.9-0.90.2
Time in novel zone, hab. session 10.30.30.80.00.50.30.30.50.60.90.70.5
Total zone transitions, hab. session 10.30.40.60.80.60.50.50.60.60.40.6-0.5
Total locomotion distance, hab. session 10.50.71.21.00.80.40.41.10.90.90.8-0.7
Locomotion velocity, hab. session 10.50.71.31.10.80.50.51.10.90.80.8-0.9
Time in familiar zone, hab. session 21.01.01.6-0.5-1.0-1.3-1.3-0.5-0.9-1.2-1.1-0.8
Time in novel zone, hab. session 22.12.24.11.01.51.51.51.31.52.01.70.6
Total zone transitions, hab. session 20.10.10.70.60.2-0.1-0.10.20.2-0.2-0.0-0.8
Total locomotion distance, hab. session 20.10.20.50.50.2-0.1-0.10.60.30.30.2-0.7
Locomotion velocity, hab. session 20.00.00.10.2-0.2-0.3-0.30.2-0.0-0.0-0.1-0.4
Novel to familiar place preference ratio0.80.91.40.71.20.90.90.91.01.21.20.0
Novelty place preference0.50.61.00.51.00.70.70.70.91.01.00.1
Time in novel zone, NPP test0.60.61.00.30.90.90.90.40.80.91.00.6
Total zone transitions, NPP test0.00.10.20.40.10.30.30.30.20.20.0-0.2
Total locomotion distance, NPP test0.10.10.30.20.10.40.40.20.30.50.30.5
Locomotion velocity, NPP test0.00.00.10.2-0.00.00.00.20.10.3-0.00.1
Intraocular pressure4.66.69.02.82.62.22.23.02.82.72.7-1.8
Delta distance traveled before/after self-admin2.93.14.7-2.2-1.9-1.5-1.5-2.0-2.0-1.7-1.71.3
Delta ambulatory time before/after self-admin3.74.55.7-2.4-2.3-2.0-2.0-2.2-2.4-2.1-2.31.2
Parametrial fat weight0.20.41.70.80.60.10.10.70.4-0.1-0.0-1.3
Pavlov. Cond. lever latency0.10.20.80.30.4-0.1-0.10.50.30.10.2-0.9
Pavlov. Cond. magazine entry latency0.10.10.9-0.3-0.10.20.2-0.2-0.00.2-0.01.0
Pavlov. Cond. change in total contacts1.71.84.3-1.5-1.5-0.6-0.6-1.7-1.2-1.1-1.02.1
Pavlov. Cond. index score0.10.20.9-0.00.10.50.5-0.10.10.30.10.9
Pavlov. Cond. latency score0.10.10.40.00.10.30.30.00.10.30.10.6
Pavlov. Cond. lever contacts0.20.21.4-0.2-0.30.40.4-0.4-0.10.0-0.01.2
Pavlov. Cond. magazine entry number0.50.63.50.30.1-0.8-0.80.60.0-0.2-0.1-1.9
Pavlov. Cond. intertrial magazine entries0.20.30.80.60.40.30.30.90.30.60.3-0.8
Pavlov. Cond. lever-magazine prob. diff.0.20.30.90.00.20.70.70.00.30.50.31.0
Pavlov. Cond. response bias0.60.74.1-0.5-0.50.60.6-0.8-0.30.1-0.02.0
Pavlov. Cond. lever latency0.10.20.50.20.3-0.1-0.10.60.40.70.4-0.3
Pavlov. Cond. magazine entry latency0.00.10.10.20.10.40.4-0.0-0.0-0.3-0.1-0.3
Pavlov. Cond. change in total contacts0.10.10.50.20.00.70.7-0.3-0.0-0.2-0.00.5
Pavlov. Cond. index score0.10.10.30.10.10.60.6-0.3-0.0-0.3-0.10.4
Pavlov. Cond. latency score0.10.10.2-0.1-0.00.40.4-0.3-0.1-0.3-0.20.4
Pavlov. Cond. lever contacts0.30.40.9-0.4-0.6-0.1-0.1-0.9-0.7-1.0-0.70.4
Pavlov. Cond. magazine entry number0.10.10.3-0.1-0.2-0.6-0.60.1-0.10.0-0.1-0.3
Pavlov. Cond. intertrial magazine entries0.60.91.8-0.8-1.0-1.3-1.3-0.6-0.9-0.8-1.1-0.2
Pavlov. Cond. lever-magazine prob. diff.0.10.10.40.10.10.60.6-0.3-0.0-0.3-0.00.4
Pavlov. Cond. response bias0.10.20.3-0.0-0.10.50.5-0.6-0.2-0.6-0.20.5
Time in closed arm before self-admin3.13.95.4-2.3-2.2-1.6-1.6-2.3-2.2-2.1-2.01.3
Time in closed arm after self-admin1.41.52.0-1.4-1.4-1.0-1.0-1.4-1.3-1.2-1.20.7
Time in open arm before self-admin2.02.23.51.91.71.41.41.51.61.41.4-0.9
Time in open arm after self-admin0.91.01.21.11.11.11.10.91.01.11.1-0.1
Bone: periosteal estimation0.10.10.3-0.5-0.4-0.2-0.2-0.5-0.3-0.5-0.20.2
Bone: periosteal perimeter0.20.30.50.60.60.50.50.50.70.20.7-0.6
Bone: post-yield work0.10.10.70.40.40.10.1-0.00.6-0.10.8-0.1
Progressive ratio test 1 active lever presses0.20.21.3-0.6-0.10.10.1-0.5-0.20.00.11.2
Progressive ratio test 1 breakpoint0.20.21.4-0.6-0.10.20.2-0.5-0.20.00.11.2
Progressive ratio test 1 inactive lever presses0.10.10.30.20.40.40.4-0.00.30.30.30.5
Progressive ratio test 2 active lever presses0.10.10.5-0.30.20.10.1-0.10.00.20.20.7
Progressive ratio test 2 breakpoint0.10.10.4-0.20.30.10.10.00.10.30.30.6
Progressive ratio test 2 inactive lever presses0.91.52.21.41.51.11.11.41.41.21.3-0.6
Incentive Sensitization - Responses0.00.10.20.20.4-0.2-0.20.40.20.10.0-0.4
Incentive Sensitization - Breakpoint0.00.10.20.20.3-0.3-0.30.30.10.1-0.0-0.4
Sum of active levers in priming session hrs 5-60.20.20.40.40.50.00.00.60.50.40.4-0.5
Progressive ratio0.30.41.1-0.6-0.7-1.0-1.0-0.4-0.5-0.6-0.40.1
Food seeking constrained by brief footshock1.92.43.9-1.2-1.6-1.8-1.8-1.3-1.6-2.0-1.6-0.3
Seeking ratio, punishment vs. effort0.60.91.5-0.9-0.9-0.5-0.5-1.2-1.1-1.2-1.20.4
Retroperitoneal fat weight0.52.34.41.91.70.80.82.01.41.20.9-2.1
Reaction time number correct0.50.91.50.91.01.01.01.11.01.20.9-0.1
Reaction time mean minus median0.51.32.50.60.81.51.50.10.91.11.21.6
Reaction time mean minus median AUC0.51.22.10.70.91.41.40.31.01.21.21.4
Reaction time num false alarms5.78.012.03.53.02.92.92.92.92.62.7-1.8
Reaction time num false alarms AUC4.57.010.93.32.82.72.72.72.82.42.5-1.8
Reaction time trials correct on left0.50.91.50.91.01.01.01.11.01.20.9-0.1
Reaction time trials on left0.61.11.81.01.11.11.11.21.11.31.0-0.2
Reaction time mean1.72.64.41.01.52.12.10.91.52.01.81.1
Reaction time mean AUC1.72.74.51.11.52.12.11.01.62.01.81.0
Median of all reaction times1.62.23.70.91.41.91.91.01.41.91.70.8
Reaction time omissions2.33.45.31.82.02.32.31.41.81.91.80.1
Reaction time false alarm rate2.33.25.32.31.91.81.81.81.81.41.6-1.5
Reaction time premature initiation rate2.73.75.9-1.2-1.7-2.4-2.4-1.1-1.9-2.4-2.2-1.5
Reaction time premature initiations0.81.52.5-0.6-0.9-1.6-1.6-0.4-1.0-1.4-1.4-1.4
Std. dev. reaction times0.81.52.80.91.01.71.70.31.11.31.31.2
Reaction time trials completed0.61.11.81.01.11.11.11.21.11.31.0-0.2
Reaction time trials AUC0.61.21.91.01.11.11.11.31.11.41.1-0.1
Run reversals in cocaine runway, females0.40.40.90.50.50.90.90.20.50.50.60.5
Run reversals in cocaine runway, males0.10.10.4-0.10.30.20.20.30.20.50.20.7
Latency to leave start box in cocaine runway0.30.40.80.80.50.30.30.90.70.60.6-0.7
Latency to leave start box in cocaine runway, F0.40.41.00.30.50.60.60.60.81.00.90.4
Latency to leave start box in cocaine runway, M0.60.63.50.8-0.1-0.5-0.50.6-0.0-0.5-0.4-1.9
Std. dev. time between licks in bursts0.10.20.4-0.5-0.3-0.4-0.4-0.0-0.5-0.3-0.7-0.1
Total sessions with >9 infusions0.00.00.1-0.20.10.10.1-0.0-0.00.10.10.3
Short access day 1 total inactive lever presses0.10.21.0-0.6-0.2-0.1-0.1-0.4-0.3-0.2-0.21.0
Short access day 10 total inactive lever presses0.10.20.4-0.1-0.3-0.4-0.4-0.2-0.4-0.6-0.6-0.5
Short access day 1 total infusions0.50.70.90.80.90.90.90.80.90.90.9-0.2
Short access day 10 total infusions0.00.00.1-0.00.2-0.3-0.30.20.0-0.0-0.1-0.4
Short access total infusions0.10.10.20.20.40.20.20.40.30.20.3-0.1
Short access day 1 locomotion1.72.12.71.61.51.41.41.41.51.61.6-0.6
Short access day 10 total locomotion0.00.10.20.10.20.30.30.10.20.30.40.2
Short access total locomotion0.40.40.70.70.70.60.60.70.70.70.8-0.3
One hour access (0.3 mA shock)0.80.92.01.21.10.30.31.21.00.50.6-1.4
Compulsive drug intake0.10.20.60.60.3-0.1-0.10.50.50.10.2-0.7
One hour access (shock baseline)0.20.40.60.70.80.30.30.80.60.40.5-0.8
Social response proportion0.10.10.4-0.5-0.10.20.2-0.1-0.20.3-0.30.7
Social responses0.60.72.71.10.80.40.41.10.60.40.2-1.6
Social time1.01.42.1-1.3-1.2-1.5-1.5-0.8-1.3-0.9-1.40.1
Soleus weight0.10.30.90.40.80.10.10.60.50.20.5-0.9
Bone: stiffness0.30.62.3-0.8-0.50.10.1-1.2-0.5-0.5-0.11.5
Tibialis anterior weight0.31.21.70.50.91.31.30.61.11.31.21.2
Time to tail flick, vehicle, before self-admin0.40.42.20.50.1-0.5-0.50.60.20.00.2-1.5
Time to tail flick, vehicle, after self-admin0.50.71.8-0.1-0.4-1.3-1.3-0.0-0.4-0.8-0.6-1.3
Time to tail flick, test, before self-admin1.31.31.81.21.10.90.91.31.21.11.3-1.1
Time to tail flick, test, after self-admin1.11.21.8-1.3-1.3-0.9-0.9-1.4-1.1-1.0-0.81.0
Delta time to tail flick, vehicle, before/after SA0.20.20.4-0.3-0.3-0.6-0.6-0.3-0.4-0.6-0.5-0.1
Delta time to tail flick, test, before/after SA2.82.86.7-2.1-1.7-0.7-0.7-2.3-1.6-1.3-1.22.6
Tibia length0.61.78.1-0.70.01.51.5-1.40.0-0.10.62.8
Ambulatory time before self-admin2.13.14.71.51.82.22.21.31.81.92.00.4
Ambulatory time after self-admin0.81.03.2-1.3-0.9-0.2-0.2-1.3-0.9-0.5-0.61.8
Bone: tissue strength0.10.10.4-0.6-0.1-0.1-0.1-0.3-0.40.0-0.40.6
Total heroin consumption0.20.30.50.60.70.50.50.60.60.40.5-0.3
Bone: trabecular number2.23.77.3-2.0-1.9-2.7-2.7-1.5-1.8-1.4-1.70.7
Bone: trabecular spacing1.31.82.71.21.41.61.61.51.21.40.9-0.8
Bone: trabecular thickness4.35.47.8-2.8-2.5-2.4-2.4-2.5-2.4-2.0-2.01.8
Bone: trabecular tissue density0.40.61.00.80.71.01.00.80.80.80.9-0.3
Water consumed over 24 hours2.33.13.9-1.8-1.8-1.8-1.8-1.9-1.9-2.0-1.80.6
Number of responses in last shaping day2.22.54.02.01.71.31.31.71.61.41.5-1.5