Hub : Genes

Nme5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 RMTg intron excision ratio chr18_26169875_26180166 0.12 0.08 8.4e-04 0.12 0.12 0.12 0.11 4.0e-04 4.0e-04 4.4e-04 6.7e-04
2 pVTA gene expression Nme5 0.08 0.07 6.4e-03 0.02 0.03 0.01 0.02 5.7e-02 1.6e-02 1.3e-01 4.6e-02
3 RMTg intron excision ratio chr18_26164061_26169757 0.09 0.07 5.4e-03 0.07 0.06 0.02 0.06 7.4e-03 1.0e-02 8.1e-02 1.1e-02
4 PL intron excision ratio chr18_26169875_26180166 0.07 0.06 7.7e-06 0.04 0.04 0.04 0.03 1.3e-05 2.7e-05 7.5e-05 1.5e-04
5 PL isoform ratio XM_003751760.5 0.03 0.02 2.9e-03 0.02 0.01 0.01 0.01 2.9e-03 1.6e-02 9.9e-03 1.8e-02
6 PL isoform ratio XM_039097262.1 0.03 0.02 1.8e-03 0.02 0.01 0.02 0.01 2.1e-03 9.3e-03 6.0e-03 1.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bone: apparent density1.21.94.5-1.01.20.40.42.1-2.1
Area under the delay curve3.43.65.1-2.32.22.22.21.0-1.0
BMI with tail7.424.032.35.5-5.7-5.4-5.5-3.43.4
BMI without tail5.110.514.13.6-3.8-3.6-3.6-2.22.2
Body weight6.326.539.25.9-5.9-6.2-6.3-2.42.4
Weight adjusted by age1.72.02.71.6-1.6-1.5-1.3-1.11.1
Bone surface1.32.34.7-1.31.40.60.62.2-2.2
Bone volume1.11.94.4-1.11.20.30.32.1-2.1
Breakpoint value in progressive ratio session0.10.10.3-0.00.20.0-0.10.6-0.6
Number of licking bursts0.50.61.1-1.00.80.90.80.4-0.4
Context. condit. distance diff. score0.00.00.10.0-0.20.0-0.1-0.30.3
Locomotion velocity, session 10.40.40.70.6-0.5-0.8-0.80.4-0.4
Locomotion distance, session 10.00.00.00.1-0.2-0.2-0.1-0.20.2
Locomotion velocity, session 21.31.52.01.2-1.4-1.0-1.0-1.41.4
Locomotion distance, session 20.20.30.6-0.80.60.70.70.1-0.1
Locomotion velocity, session 30.30.30.60.6-0.6-0.6-0.8-0.30.3
Locomotion distance, session 30.30.30.7-0.40.50.20.10.9-0.9
Stereotopy head waving bouts, day 31.72.03.0-1.71.61.71.70.7-0.7
Stereotopy head waving duration, day 30.30.30.6-0.20.20.60.6-0.80.8
Locomotion velocity, session 70.40.40.70.4-0.3-0.7-0.90.8-0.8
Locomotion distance, session 70.81.02.3-0.80.90.30.31.5-1.5
Stereotopy head waving bouts, day 70.80.91.60.9-0.8-0.4-0.6-1.31.3
Stereotopy head waving duration, day 71.21.53.90.7-0.9-0.0-0.2-2.02.0
Locomotion velocity, session 81.31.63.80.8-1.0-0.3-0.3-2.02.0
Locomotion distance, session 80.00.00.1-0.1-0.00.10.1-0.30.3
Degree of sensitization distance0.10.10.20.3-0.3-0.4-0.30.0-0.0
Degree of sensitization stereotypy1.11.23.00.8-0.9-0.1-0.3-1.71.7
Conditioned locomotion0.30.41.0-0.10.1-0.4-0.11.0-1.0
Cocaine response after cond. corrected0.50.61.20.8-0.7-1.1-1.00.3-0.3
Cocaine response after cond. not corrected0.00.00.10.1-0.2-0.1-0.0-0.20.2
Cocaine response before conditioning3.34.07.3-2.11.72.72.7-1.11.1
Saline control response0.50.61.2-0.90.71.11.0-0.40.4
Bone: connectivity density2.13.34.5-1.81.91.31.42.1-2.1
Bone: cortical apparent density0.81.02.0-1.11.11.41.3-0.20.2
Bone: cortical area2.74.05.2-2.32.32.01.71.8-1.8
Bone: cortical porosity0.50.50.90.9-0.7-1.0-0.90.0-0.0
Bone: cortical porosity0.30.40.70.7-0.6-0.8-0.70.0-0.0
Bone: cortical thickness1.83.04.1-2.02.01.71.61.5-1.5
Bone: cortical thickness0.40.40.7-0.70.70.50.40.8-0.8
Bone: cortical tissue density0.60.81.6-1.00.91.31.1-0.30.3
Condit. Reinf. active minus inactive responses2.02.33.0-1.71.71.61.71.1-1.1
Condit. Reinf. active-inactive response ratio1.01.11.7-1.21.21.21.30.4-0.4
Condit. Reinf. active responses2.42.93.5-1.81.91.41.51.8-1.8
Condit. Reinf. inactive responses2.02.34.0-1.41.50.90.92.0-2.0
Incentive salience index mean1.82.13.0-1.61.71.61.70.9-0.9
Condit. Reinf. lever presses1.21.62.4-1.41.51.51.50.7-0.7
Condit. Reinf. active minus inactive responses3.24.05.7-2.32.32.32.41.1-1.1
Condit. Reinf. active-inactive response ratio0.40.51.2-0.30.60.10.21.1-1.1
Condit. Reinf. active responses6.89.415.2-3.63.43.93.90.8-0.8
Condit. Reinf. inactive responses6.37.713.7-3.32.93.73.7-0.00.0
Condit. Reinf. lever presses2.12.83.7-1.91.91.81.81.2-1.2
Condit. Reinf. lever reinforcers received6.08.514.3-3.43.23.73.80.6-0.6
Conditioned reinforcement - actives0.10.10.1-0.00.10.30.1-0.40.4
Conditioned reinforcement - inactives0.10.10.2-0.40.30.40.30.4-0.4
Conditioned locomotion0.10.10.3-0.40.40.60.30.1-0.1
Patch foraging indifference point 0 sec1.62.65.1-1.91.62.32.0-0.40.4
Patch foraging indifference point AUC3.33.84.8-2.22.21.91.91.7-1.7
Delay disc. indifference point, 0s delay1.31.52.0-1.41.41.21.30.9-0.9
Delay disc. indifference point, 16s delay3.73.85.6-2.32.22.32.40.8-0.8
Delay disc. indifference point, 2s delay1.01.11.5-1.01.20.70.81.2-1.2
Delay disc. indifference point, 24s delay0.70.71.0-1.01.00.80.80.7-0.7
Delay disc. indifference point, 4s delay1.51.52.1-1.21.40.91.01.5-1.5
Delay disc. indifference point, 8s delay4.44.66.6-2.62.42.52.51.1-1.1
Indifference point function ln k7.610.513.73.7-3.7-3.4-3.4-2.52.5
Indifference point function log k7.610.513.73.7-3.7-3.4-3.4-2.52.5
Patch foraging total patch changes 0 sec1.52.54.8-1.81.62.22.0-0.30.3
Patch foraging total patch changes 12 sec6.78.713.4-3.63.33.53.71.1-1.1
Patch foraging total patch changes 18 sec6.38.19.8-3.03.12.42.33.1-3.1
Patch foraging total patch changes 24 sec2.42.94.3-2.11.92.02.00.9-0.9
Patch foraging total patch changes 6 sec3.34.97.1-2.72.52.62.41.3-1.3
Patch foraging time to switch 0 sec0.10.10.20.4-0.4-0.3-0.3-0.30.3
Patch foraging water rate 0 sec0.00.00.00.0-0.1-0.1-0.0-0.10.1
Patch foraging water rate 12 sec0.40.71.30.8-0.8-1.0-1.20.5-0.5
Patch foraging water rate 18 sec0.10.20.30.5-0.5-0.3-0.2-0.50.5
Patch foraging water rate 24 sec0.20.20.40.4-0.5-0.5-0.60.4-0.4
Patch foraging water rate 6 sec0.30.51.10.1-0.1-0.5-0.51.1-1.1
Seeking ratio, delayed vs. immediate footshock0.40.50.9-0.70.60.90.9-0.30.3
Distance traveled before self-admin1.21.32.7-0.71.20.60.41.7-1.7
Distance traveled after self-admin2.02.23.1-1.41.81.31.21.6-1.6
Extensor digitorum longus weight1.97.39.73.1-3.1-2.9-3.0-1.91.9
Bone: elastic displacement1.51.72.11.4-1.4-1.1-1.1-1.41.4
Bone: elastic work2.53.24.21.8-2.0-1.4-1.4-2.12.1
Bone: endosteal estimation0.30.60.9-1.00.80.90.80.4-0.4
Bone: endosteal perimeter0.10.10.2-0.40.40.50.40.1-0.1
Epididymis fat weight4.811.314.63.7-3.8-3.3-3.2-3.03.0
Delta time in closed arm before/after self-admin4.44.36.12.1-2.1-1.5-1.5-2.52.5
Delta time in open arm before/after self-admin1.71.63.5-1.01.00.40.71.9-1.9
Diff in mean of infusions in LGA sessions0.70.71.30.7-0.5-1.1-1.10.8-0.8
Delay discount exponential model param3.84.05.52.3-2.3-2.2-2.2-1.31.3
Extinction: sum of active levers before priming0.80.82.1-0.10.5-0.30.01.5-1.5
Active lever presses in extinction session 62.42.43.2-1.71.81.41.31.5-1.5
Bone: final force1.11.72.3-1.51.51.41.31.1-1.1
Bone: final moment0.61.01.3-1.11.11.00.90.8-0.8
Food consumed during 24 hour testing period1.31.62.80.9-0.8-1.5-1.71.2-1.2
Glucose5.07.512.73.3-3.0-3.5-3.6-0.60.6
Heart weight2.43.46.52.1-1.9-2.6-2.50.2-0.2
Delay discount hyperbolic model param3.63.95.22.3-2.3-2.0-2.1-1.41.4
Intermittent access intake day 1-15 change1.11.11.90.9-1.1-0.7-0.6-1.41.4
Intermittent access intake escalation0.40.40.70.5-0.7-0.5-0.3-0.80.8
Intermittent access intake escalation 20.30.30.30.6-0.6-0.6-0.3-0.50.5
Intermitt. access day 1 inactive lever presses0.00.00.00.1-0.2-0.10.0-0.00.0
Intermitt. access day 15 inactive lever presses0.10.10.20.3-0.5-0.2-0.3-0.50.5
Intermitt. access escalation Index1.00.91.41.2-1.1-1.2-1.1-0.30.3
Intermittent access day 1 total infusions0.50.61.3-0.30.10.90.5-1.11.1
Intermittent access day 15 total infusions0.70.82.1-0.0-0.30.50.3-1.41.4
Intermittent access terminal intake (last 3 days)0.91.02.70.0-0.40.60.4-1.61.6
Intermittent access total infusions0.60.61.80.2-0.40.40.1-1.31.3
Intermittent access day 1 locomotion0.40.41.20.1-0.30.2-0.1-1.11.1
Intermittent access day 15 total locomotion2.93.24.41.9-2.1-1.6-1.9-1.61.6
Intermittent access total locomotion1.82.03.11.3-1.5-0.8-1.2-1.81.8
Intermittent access standard deviation0.50.51.20.4-0.5-0.20.1-1.11.1
Left kidney weight0.20.61.20.5-0.4-1.1-0.80.9-0.9
Right kidney weight0.20.50.80.7-0.9-0.9-0.8-0.40.4
Cocaine induced anxiety0.50.61.50.10.3-0.4-0.41.2-1.2
Post-drug Anxiety1.01.12.6-0.70.90.30.11.6-1.6
Baseline Anxiety0.20.20.4-0.40.30.60.5-0.30.3
Tail length0.10.30.40.6-0.7-0.5-0.6-0.40.4
Length with tail0.52.03.81.6-1.4-1.9-2.00.1-0.1
Length without tail0.61.22.31.3-1.2-1.5-1.5-0.10.1
Times rat made contact with spout1.31.54.0-0.10.3-0.6-0.62.0-2.0
Lifetime Intake0.91.02.80.3-0.50.40.1-1.71.7
Liver weight, left0.10.10.30.2-0.20.10.0-0.50.5
Liver weight, right1.01.62.3-0.90.51.41.5-1.51.5
Locomotor activity0.10.20.5-0.30.5-0.00.20.7-0.7
Locomotor testing distance0.20.30.7-0.30.4-0.10.10.9-0.9
Locomotor testing rearing0.40.61.0-0.90.80.91.00.3-0.3
Locomotion in novel chamber0.30.30.90.2-0.30.20.3-0.90.9
Locomotion in novel chamber post-restriction0.50.71.40.5-0.8-0.3-0.3-1.21.2
Fecal boli incidents, locomotor time 10.30.30.70.3-0.4-0.0-0.0-0.90.9
Change in fecal boli incidents, locomotor task0.20.20.70.2-0.2-0.00.1-0.80.8
Time >=10cm from walls, locomotor time 10.30.30.60.5-0.5-0.8-0.60.1-0.1
Bouts of movement, locomotor time 10.60.61.2-1.10.80.91.10.1-0.1
Total resting periods, locomotor time 10.50.51.1-0.90.60.91.0-0.10.1
Rest time, locomotor task time 10.20.20.40.4-0.7-0.5-0.3-0.50.5
Distance moved, locomotor task time 10.30.30.7-0.30.50.2-0.00.8-0.8
Vertical activity count, locomotor time 10.60.71.60.20.2-0.5-0.61.3-1.3
Time >=10cm from walls, locomotor time 23.03.25.92.2-1.8-2.3-2.4-0.10.1
Bouts of movement, locomotor time 20.20.30.4-0.40.30.70.5-0.60.6
Total resting periods, locomotor time 20.10.10.2-0.20.00.30.2-0.50.5
Rest time, locomotor task time 20.91.11.91.2-1.2-1.4-1.2-0.30.3
Distance moved, locomotor task time 20.40.41.0-0.50.70.30.11.0-1.0
Vertical activity count, locomotor time 21.11.22.5-0.71.10.50.31.6-1.6
Light reinforcement 11.22.23.4-1.81.71.81.70.7-0.7
Light reinforcement 23.74.96.6-2.42.62.22.31.8-1.8
Bone: marrow area0.30.60.9-1.00.80.90.80.4-0.4
Bone: maximum diameter2.24.05.5-2.32.32.12.01.5-1.5
Bone: maximum force0.50.80.9-0.91.00.80.70.9-0.9
Bone: maximum moment0.20.30.5-0.50.50.40.30.7-0.7
Mean time between licks in bursts0.40.51.10.7-0.8-1.0-0.90.0-0.0
Mean num. licks in bursts0.81.01.81.1-0.9-1.3-1.30.5-0.5
Cd content in liver0.10.10.1-0.0-0.00.20.3-0.40.4
Co content in liver0.30.40.60.4-0.2-0.8-0.50.8-0.8
Cu content in liver3.54.36.5-2.42.42.62.40.9-0.9
Fe content in liver3.44.16.8-1.82.11.31.22.6-2.6
K content in liver0.40.30.5-0.30.20.70.7-0.70.7
Mg content in liver1.01.12.1-1.10.91.41.3-0.50.5
Mn content in liver0.80.91.20.9-1.1-0.8-0.8-1.01.0
Na content in liver0.80.81.7-0.50.90.40.41.3-1.3
Rb content in liver0.91.11.7-1.00.51.31.1-1.11.1
Se content in liver0.20.20.3-0.50.40.40.50.3-0.3
Sr content in liver1.31.21.8-1.11.31.11.10.9-0.9
Zn content in liver2.42.74.0-1.91.91.82.01.0-1.0
Bone: minimum diameter1.12.12.8-1.51.51.21.01.7-1.7
Time in familiar zone, hab. session 10.40.30.60.3-0.2-0.6-0.60.7-0.7
Time in novel zone, hab. session 10.70.71.4-0.90.81.21.1-0.40.4
Total zone transitions, hab. session 11.41.93.51.4-1.1-1.9-1.80.8-0.8
Total locomotion distance, hab. session 10.91.23.3-0.30.7-0.1-0.21.8-1.8
Locomotion velocity, hab. session 10.71.12.9-0.30.6-0.1-0.21.7-1.7
Time in familiar zone, hab. session 22.22.23.7-1.91.61.71.80.7-0.7
Time in novel zone, hab. session 21.51.52.61.6-1.2-1.5-1.6-0.20.2
Total zone transitions, hab. session 20.10.20.20.4-0.5-0.4-0.4-0.30.3
Total locomotion distance, hab. session 20.40.50.6-0.70.70.50.40.8-0.8
Locomotion velocity, hab. session 20.30.40.8-0.50.50.20.10.9-0.9
Novel to familiar place preference ratio0.60.61.31.1-0.8-0.9-1.0-0.10.1
Novelty place preference0.80.91.71.3-1.0-1.0-1.1-0.30.3
Time in novel zone, NPP test0.70.81.51.2-0.9-1.0-1.0-0.30.3
Total zone transitions, NPP test0.00.10.2-0.00.1-0.2-0.10.4-0.4
Total locomotion distance, NPP test0.91.32.2-1.01.20.70.71.5-1.5
Locomotion velocity, NPP test1.11.52.3-1.21.30.80.91.5-1.5
Intraocular pressure4.25.88.52.8-2.8-2.9-2.8-1.21.2
Delta distance traveled before/after self-admin1.61.72.7-1.61.51.51.50.7-0.7
Delta ambulatory time before/after self-admin2.42.63.4-1.81.81.51.51.5-1.5
Parametrial fat weight1.02.03.51.3-1.4-0.8-0.9-1.91.9
Pavlov. Cond. lever latency0.10.10.1-0.30.30.20.20.3-0.3
Pavlov. Cond. magazine entry latency0.10.20.4-0.40.30.60.6-0.30.3
Pavlov. Cond. change in total contacts0.40.40.9-0.40.60.20.31.0-1.0
Pavlov. Cond. index score0.00.00.0-0.10.10.10.20.1-0.1
Pavlov. Cond. latency score0.00.00.00.2-0.1-0.10.0-0.20.2
Pavlov. Cond. lever contacts0.10.10.2-0.20.20.40.5-0.20.2
Pavlov. Cond. magazine entry number0.10.20.20.5-0.5-0.4-0.5-0.40.4
Pavlov. Cond. intertrial magazine entries1.31.64.0-0.70.90.20.12.0-2.0
Pavlov. Cond. lever-magazine prob. diff.0.10.10.1-0.30.30.30.40.2-0.2
Pavlov. Cond. response bias0.10.20.2-0.40.40.30.40.4-0.4
Pavlov. Cond. lever latency1.41.82.61.5-1.6-1.5-1.4-1.01.0
Pavlov. Cond. magazine entry latency0.20.20.4-0.40.50.30.30.6-0.6
Pavlov. Cond. change in total contacts1.92.63.8-1.81.91.91.90.9-0.9
Pavlov. Cond. index score0.70.91.4-1.11.21.11.10.6-0.6
Pavlov. Cond. latency score0.60.81.2-1.01.11.01.10.4-0.4
Pavlov. Cond. lever contacts1.01.42.0-1.41.31.41.30.7-0.7
Pavlov. Cond. magazine entry number0.81.02.01.1-1.0-1.3-1.40.2-0.2
Pavlov. Cond. intertrial magazine entries1.11.44.0-0.40.7-0.2-0.32.0-2.0
Pavlov. Cond. lever-magazine prob. diff.0.81.01.4-1.11.21.11.10.7-0.7
Pavlov. Cond. response bias1.92.63.6-1.91.81.91.80.8-0.8
Time in closed arm before self-admin1.01.21.90.7-0.5-1.2-1.41.2-1.2
Time in closed arm after self-admin1.01.02.21.1-1.0-1.1-1.5-0.20.2
Time in open arm before self-admin0.70.82.1-0.0-0.20.40.6-1.51.5
Time in open arm after self-admin0.30.30.7-0.50.50.10.40.8-0.8
Bone: periosteal estimation1.12.23.2-1.81.71.61.41.2-1.2
Bone: periosteal perimeter0.50.81.4-1.11.01.21.00.2-0.2
Bone: post-yield work0.20.20.3-0.50.50.50.50.4-0.4
Progressive ratio test 1 active lever presses0.00.00.10.2-0.2-0.0-0.3-0.10.1
Progressive ratio test 1 breakpoint0.10.10.10.2-0.20.0-0.3-0.30.3
Progressive ratio test 1 inactive lever presses0.30.30.6-0.30.10.60.7-0.80.8
Progressive ratio test 2 active lever presses0.10.10.10.4-0.4-0.0-0.4-0.20.2
Progressive ratio test 2 breakpoint0.10.10.30.5-0.4-0.2-0.60.0-0.0
Progressive ratio test 2 inactive lever presses0.20.30.60.4-0.5-0.0-0.3-0.70.7
Incentive Sensitization - Responses0.10.10.30.1-0.0-0.2-0.10.5-0.5
Incentive Sensitization - Breakpoint0.20.20.70.10.1-0.2-0.10.8-0.8
Sum of active levers in priming session hrs 5-64.84.76.3-2.22.51.91.92.2-2.2
Progressive ratio0.10.20.4-0.10.10.30.3-0.60.6
Food seeking constrained by brief footshock0.10.10.3-0.30.30.50.5-0.20.2
Seeking ratio, punishment vs. effort0.00.00.00.0-0.2-0.1-0.1-0.10.1
Retroperitoneal fat weight3.511.314.83.8-3.8-3.7-3.6-2.52.5
Reaction time number correct0.91.42.61.3-1.3-1.5-1.60.3-0.3
Reaction time mean minus median0.71.02.0-0.81.00.40.31.4-1.4
Reaction time mean minus median AUC1.21.54.2-0.50.8-0.0-0.12.0-2.0
Reaction time num false alarms0.30.40.80.9-0.7-0.8-0.7-0.30.3
Reaction time num false alarms AUC0.71.01.61.3-1.1-1.2-1.0-0.60.6
Reaction time trials correct on left0.91.42.61.3-1.3-1.5-1.60.3-0.3
Reaction time trials on left1.01.42.71.3-1.3-1.5-1.60.2-0.2
Reaction time mean0.20.30.60.7-0.5-0.6-0.7-0.30.3
Reaction time mean AUC0.10.10.20.4-0.3-0.3-0.4-0.20.2
Median of all reaction times0.81.01.41.2-1.1-0.9-1.0-0.90.9
Reaction time omissions0.00.00.1-0.10.10.20.1-0.30.3
Reaction time false alarm rate0.10.20.30.5-0.3-0.4-0.2-0.60.6
Reaction time premature initiation rate1.62.23.2-1.81.51.31.31.4-1.4
Reaction time premature initiations0.71.01.5-1.10.90.70.71.2-1.2
Std. dev. reaction times0.91.23.00.00.3-0.6-0.81.7-1.7
Reaction time trials completed1.01.42.71.3-1.3-1.5-1.60.2-0.2
Reaction time trials AUC1.01.42.71.3-1.2-1.5-1.60.3-0.3
Run reversals in cocaine runway, females0.50.51.2-0.60.61.01.1-0.20.2
Run reversals in cocaine runway, males1.01.02.70.3-0.50.30.3-1.61.6
Latency to leave start box in cocaine runway1.51.62.2-1.51.41.41.40.9-0.9
Latency to leave start box in cocaine runway, F0.70.81.2-1.10.90.90.90.7-0.7
Latency to leave start box in cocaine runway, M0.10.10.2-0.30.40.40.40.2-0.2
Std. dev. time between licks in bursts0.10.10.2-0.20.20.00.20.4-0.4
Total sessions with >9 infusions0.80.91.11.1-1.0-0.6-0.9-1.01.0
Short access day 1 total inactive lever presses0.91.01.3-1.01.20.80.81.1-1.1
Short access day 10 total inactive lever presses0.30.30.5-0.60.60.30.30.7-0.7
Short access day 1 total infusions0.91.02.60.2-0.30.60.3-1.61.6
Short access day 10 total infusions0.00.10.1-0.20.20.40.20.1-0.1
Short access total infusions1.01.23.0-0.0-0.20.80.5-1.71.7
Short access day 1 locomotion0.70.71.81.0-0.8-1.0-1.3-0.10.1
Short access day 10 total locomotion2.52.83.71.8-1.9-1.6-1.6-1.51.5
Short access total locomotion1.61.62.61.2-1.3-0.7-1.0-1.61.6
One hour access (0.3 mA shock)0.81.02.30.6-0.80.1-0.3-1.51.5
Compulsive drug intake0.30.30.50.7-0.5-0.6-0.60.0-0.0
One hour access (shock baseline)0.40.41.20.0-0.30.40.2-1.11.1
Social response proportion2.32.55.11.3-1.4-0.7-0.9-2.32.3
Social responses0.81.12.0-0.91.01.41.2-0.70.7
Social time3.34.411.81.0-1.4-0.1-0.1-3.43.4
Soleus weight3.08.713.92.8-3.0-1.9-1.9-3.73.7
Bone: stiffness0.71.11.4-1.21.21.01.01.0-1.0
Tibialis anterior weight1.34.66.32.3-2.5-2.2-2.3-1.71.7
Time to tail flick, vehicle, before self-admin2.72.74.1-1.92.01.91.81.0-1.0
Time to tail flick, vehicle, after self-admin0.20.20.2-0.40.40.40.50.5-0.5
Time to tail flick, test, before self-admin0.10.10.40.10.2-0.3-0.10.6-0.6
Time to tail flick, test, after self-admin1.11.22.0-0.80.71.41.4-1.01.0
Delta time to tail flick, vehicle, before/after SA1.41.42.11.2-1.5-0.9-0.9-1.31.3
Delta time to tail flick, test, before/after SA1.51.43.60.1-0.30.70.6-1.91.9
Tibia length0.72.13.91.4-1.2-2.0-1.90.9-0.9
Ambulatory time before self-admin0.70.81.8-0.40.80.30.31.3-1.3
Ambulatory time after self-admin2.22.43.2-1.41.71.21.21.8-1.8
Bone: tissue strength0.10.10.2-0.00.1-0.2-0.10.5-0.5
Total heroin consumption0.00.00.10.10.10.10.1-0.20.2
Bone: trabecular number0.71.22.9-0.70.80.10.21.7-1.7
Bone: trabecular spacing0.70.92.40.2-0.50.10.2-1.61.6
Bone: trabecular thickness0.30.40.8-0.60.60.20.20.9-0.9
Bone: trabecular tissue density0.30.50.70.6-0.7-0.5-0.5-0.80.8
Water consumed over 24 hours3.44.111.2-0.81.1-0.2-0.33.3-3.3
Number of responses in last shaping day0.30.30.6-0.80.40.80.6-0.30.3