Hub : Genes

Nipsnap1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	alternative TSS	NM_001100730.1	0.09	0.07	5.2e-05	0.01	0.03	0.03	0.03	7.4e-03	1.3e-04	6.4e-04	4.0e-04
2	Adipose	alternative TSS	XM_006251337.4	0.09	0.07	2.4e-05	0.02	0.04	0.03	0.03	4.3e-03	6.8e-05	2.8e-04	1.8e-04
3	Adipose	isoform ratio	NM_001100730.1	0.1	0.08	7.8e-05	0.02	0.03	0.04	0.03	3.4e-03	1.9e-04	6.8e-05	1.3e-04
4	Adipose	isoform ratio	XM_006251337.4	0.09	0.07	1.1e-04	0.02	0.03	0.03	0.03	2.5e-03	3.4e-04	1.1e-04	2.1e-04
5	Adipose	gene expression	Nipsnap1	0.49	0.15	2.8e-16	0.11	0.15	0.15	0.14	3.2e-12	2.2e-16	1.7e-16	9.3e-15

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.3	0.5	0.7	-0.6	0.6	0.8	-0.8	0.8
Area under the delay curve	0.2	0.3	0.6	-0.8	0.7	-0.3	0.3	0.0
BMI with tail	0.1	0.3	0.3	0.5	-0.5	-0.6	0.6	-0.5
BMI without tail	0.1	0.7	1.3	-1.1	1.1	0.6	-0.5	0.7
Body weight	0.2	0.7	1.7	-1.3	1.2	-0.0	0.0	0.4
Weight adjusted by age	0.4	1.1	1.4	-1.2	1.2	0.8	-0.8	1.0
Bone surface	0.1	0.2	0.3	-0.5	0.5	0.3	-0.3	0.4
Bone volume	0.2	0.3	0.4	-0.6	0.6	0.5	-0.5	0.6
Breakpoint value in progressive ratio session	0.0	0.1	0.1	-0.3	0.3	-0.2	0.2	-0.1
Number of licking bursts	0.2	0.5	1.3	-1.1	1.1	0.2	-0.2	0.4
Context. condit. distance diff. score	0.3	0.3	0.8	0.9	-0.8	0.4	-0.3	0.0
Locomotion velocity, session 1	4.1	4.6	4.9	2.1	-2.1	-2.1	2.1	-2.2
Locomotion distance, session 1	0.5	0.7	1.0	-0.5	0.6	1.0	-1.0	0.8
Locomotion velocity, session 2	2.9	3.5	3.6	1.9	-1.9	-1.9	1.9	-1.9
Locomotion distance, session 2	0.6	0.9	1.7	1.3	-1.3	-0.5	0.5	-0.7
Locomotion velocity, session 3	0.4	0.4	0.8	0.1	-0.1	0.9	-0.9	0.7
Locomotion distance, session 3	0.1	0.1	0.1	-0.3	0.3	0.3	-0.3	0.4
Stereotopy head waving bouts, day 3	0.2	0.3	0.5	-0.1	0.1	0.7	-0.7	0.6
Stereotopy head waving duration, day 3	0.2	0.3	0.7	0.8	-0.8	0.0	-0.0	-0.2
Locomotion velocity, session 7	0.0	0.0	0.1	0.0	-0.0	-0.2	0.2	-0.2
Locomotion distance, session 7	0.4	0.5	0.8	0.9	-0.9	-0.5	0.5	-0.7
Stereotopy head waving bouts, day 7	0.0	0.1	0.1	-0.2	0.2	0.2	-0.2	0.3
Stereotopy head waving duration, day 7	0.4	0.6	0.7	-0.7	0.7	0.8	-0.8	0.8
Locomotion velocity, session 8	1.5	1.8	2.8	1.7	-1.7	-1.0	1.0	-1.2
Locomotion distance, session 8	0.8	1.1	2.9	1.7	-1.6	0.2	-0.2	-0.4
Degree of sensitization distance	1.5	1.6	2.7	1.6	-1.6	-0.9	0.9	-1.1
Degree of sensitization stereotypy	0.0	0.0	0.1	-0.3	0.3	0.1	-0.1	0.2
Conditioned locomotion	0.9	1.1	1.7	-0.6	0.6	1.3	-1.3	1.1
Cocaine response after cond. corrected	0.2	0.2	0.6	-0.8	0.8	-0.1	0.1	0.1
Cocaine response after cond. not corrected	0.6	0.9	2.0	-1.4	1.4	0.5	-0.5	0.6
Cocaine response before conditioning	0.3	0.3	0.5	-0.4	0.4	0.7	-0.7	0.6
Saline control response	0.3	0.4	0.9	0.9	-0.9	-0.4	0.4	-0.5
Bone: connectivity density	0.2	0.3	0.5	-0.4	0.4	0.7	-0.7	0.6
Bone: cortical apparent density	0.1	0.1	0.3	-0.5	0.5	0.0	-0.0	0.1
Bone: cortical area	0.6	0.9	2.0	-1.4	1.4	0.4	-0.4	0.7
Bone: cortical porosity	0.1	0.2	0.2	-0.4	0.4	0.4	-0.4	0.4
Bone: cortical porosity	0.1	0.1	0.2	-0.2	0.3	0.5	-0.5	0.4
Bone: cortical thickness	1.7	2.9	4.4	-2.1	2.1	1.3	-1.3	1.6
Bone: cortical thickness	1.5	1.8	2.4	-1.0	1.1	1.6	-1.6	1.4
Bone: cortical tissue density	0.1	0.1	0.2	-0.5	0.4	-0.1	0.1	0.0
Condit. Reinf. active minus inactive responses	2.0	2.2	2.7	1.3	-1.3	-1.7	1.7	-1.5
Condit. Reinf. active-inactive response ratio	7.0	7.5	7.6	2.7	-2.8	-2.7	2.7	-2.7
Condit. Reinf. active responses	0.6	0.8	1.0	0.8	-0.8	-1.0	1.0	-0.9
Condit. Reinf. inactive responses	1.4	1.8	1.9	-1.4	1.4	1.2	-1.2	1.4
Incentive salience index mean	0.6	0.8	1.2	0.6	-0.6	-1.1	1.1	-1.0
Condit. Reinf. lever presses	0.1	0.2	0.3	-0.5	0.5	0.3	-0.3	0.3
Condit. Reinf. active minus inactive responses	0.1	0.2	0.3	0.6	-0.6	-0.0	0.1	-0.3
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.3	0.5	-0.5	-0.3	0.4	-0.5
Condit. Reinf. active responses	0.3	0.4	0.8	0.9	-0.9	-0.3	0.3	-0.5
Condit. Reinf. inactive responses	0.4	0.6	1.1	1.0	-1.0	-0.5	0.5	-0.7
Condit. Reinf. lever presses	0.0	0.1	0.1	0.2	-0.2	0.4	-0.4	0.2
Condit. Reinf. lever reinforcers received	0.2	0.3	0.6	0.8	-0.8	-0.2	0.3	-0.5
Conditioned reinforcement - actives	0.0	0.1	0.2	-0.4	0.4	-0.1	0.1	0.1
Conditioned reinforcement - inactives	0.1	0.2	0.3	-0.1	0.1	-0.5	0.5	-0.4
Conditioned locomotion	0.3	0.4	1.0	-1.0	0.9	0.3	-0.3	0.5
Patch foraging indifference point 0 sec	0.2	0.5	1.2	-1.1	1.1	0.2	-0.2	0.5
Patch foraging indifference point AUC	0.0	0.1	0.1	0.2	-0.2	-0.3	0.3	-0.3
Delay disc. indifference point, 0s delay	0.5	0.5	1.1	-1.0	1.0	0.4	-0.4	0.6
Delay disc. indifference point, 16s delay	0.6	0.9	1.6	0.3	-0.4	-1.3	1.3	-1.0
Delay disc. indifference point, 2s delay	2.2	2.5	3.6	-1.9	1.9	1.3	-1.2	1.5
Delay disc. indifference point, 24s delay	0.2	0.4	0.7	0.2	-0.2	-0.8	0.9	-0.7
Delay disc. indifference point, 4s delay	1.1	1.2	2.3	-1.5	1.5	0.6	-0.6	0.9
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	-0.1	0.1	-0.5	0.5	-0.3
Indifference point function ln k	0.2	0.7	0.9	-0.8	0.8	0.9	-0.9	1.0
Indifference point function log k	0.2	0.7	0.9	-0.8	0.8	0.9	-0.9	1.0
Patch foraging total patch changes 0 sec	0.1	0.3	0.8	-0.9	0.9	-0.0	0.0	0.3
Patch foraging total patch changes 12 sec	0.2	0.3	0.6	-0.8	0.7	0.1	-0.1	0.3
Patch foraging total patch changes 18 sec	0.7	1.6	2.5	0.7	-0.8	-1.6	1.6	-1.4
Patch foraging total patch changes 24 sec	0.3	1.1	1.7	1.3	-1.3	-0.7	0.7	-1.0
Patch foraging total patch changes 6 sec	0.1	0.2	0.4	-0.6	0.6	-0.1	0.1	0.1
Patch foraging time to switch 0 sec	0.0	0.0	0.1	0.1	-0.1	0.2	-0.2	0.1
Patch foraging water rate 0 sec	0.1	0.3	0.6	-0.1	0.0	-0.8	0.8	-0.6
Patch foraging water rate 12 sec	0.0	0.0	0.0	0.0	-0.0	-0.0	0.0	0.0
Patch foraging water rate 18 sec	1.3	2.8	3.0	-1.6	1.6	1.7	-1.7	1.7
Patch foraging water rate 24 sec	0.7	1.0	1.1	0.9	-0.9	-1.0	1.0	-1.0
Patch foraging water rate 6 sec	0.2	0.3	0.6	-0.7	0.7	0.4	-0.4	0.5
Seeking ratio, delayed vs. immediate footshock	0.0	0.1	0.1	0.2	-0.2	-0.3	0.3	-0.3
Distance traveled before self-admin	1.0	2.2	2.5	-1.6	1.6	1.4	-1.4	1.5
Distance traveled after self-admin	2.1	3.6	4.3	-1.8	1.8	1.9	-1.9	2.1
Extensor digitorum longus weight	0.6	2.4	5.6	-2.4	2.3	0.4	-0.4	1.1
Bone: elastic displacement	0.7	0.9	1.2	-0.7	0.7	1.1	-1.1	1.0
Bone: elastic work	1.9	2.4	2.6	-1.6	1.6	1.5	-1.5	1.6
Bone: endosteal estimation	0.0	0.0	0.0	-0.2	0.2	-0.1	0.1	0.0
Bone: endosteal perimeter	0.0	0.1	0.2	-0.2	0.1	-0.4	0.4	-0.3
Epididymis fat weight	0.2	1.1	1.6	-1.2	1.2	0.8	-0.8	1.0
Delta time in closed arm before/after self-admin	0.6	0.6	1.0	1.0	-0.9	0.7	-0.7	0.3
Delta time in open arm before/after self-admin	0.6	0.7	1.1	-0.7	0.6	-1.1	1.1	-0.7
Diff in mean of infusions in LGA sessions	0.0	0.0	0.0	-0.0	0.0	0.1	-0.1	-0.1
Delay discount exponential model param	0.2	0.3	0.6	0.8	-0.7	0.3	-0.3	-0.1
Extinction: sum of active levers before priming	0.3	0.4	0.5	0.6	-0.6	-0.7	0.7	-0.5
Active lever presses in extinction session 6	0.5	0.5	0.6	-0.7	0.7	0.7	-0.7	0.8
Bone: final force	0.1	0.1	0.2	-0.5	0.5	0.2	-0.2	0.3
Bone: final moment	0.2	0.3	0.5	-0.7	0.7	0.3	-0.3	0.5
Food consumed during 24 hour testing period	0.7	1.4	2.3	0.7	-0.7	-1.5	1.5	-1.3
Glucose	17.6	27.8	40.4	3.6	-3.8	-6.4	6.4	-5.6
Heart weight	1.5	2.4	2.6	1.4	-1.5	-1.6	1.6	-1.6
Delay discount hyperbolic model param	0.3	0.4	0.9	1.0	-0.9	0.1	-0.1	-0.3
Intermittent access intake day 1-15 change	0.2	0.9	1.4	0.5	-0.5	-1.2	1.2	-1.0
Intermittent access intake escalation	0.1	0.7	1.1	0.4	-0.5	-1.0	1.0	-0.9
Intermittent access intake escalation 2	0.1	0.2	0.3	0.3	-0.3	-0.5	0.5	-0.5
Intermitt. access day 1 inactive lever presses	0.0	0.4	0.6	0.8	-0.7	-0.5	0.5	-0.7
Intermitt. access day 15 inactive lever presses	0.5	2.6	3.7	1.0	-1.1	-1.9	1.9	-1.8
Intermitt. access escalation Index	0.8	2.5	2.8	1.5	-1.5	-1.6	1.6	-1.7
Intermittent access day 1 total infusions	0.4	1.1	1.5	-1.2	1.2	0.8	-0.8	1.0
Intermittent access day 15 total infusions	0.1	0.3	0.6	-0.8	0.7	-0.3	0.3	0.1
Intermittent access terminal intake (last 3 days)	0.2	0.3	0.7	-0.8	0.8	-0.0	0.0	0.2
Intermittent access total infusions	0.4	0.5	1.1	-1.1	1.0	0.2	-0.2	0.5
Intermittent access day 1 locomotion	0.5	0.9	0.9	-0.9	0.9	1.0	-1.0	1.0
Intermittent access day 15 total locomotion	0.0	0.2	0.3	-0.5	0.5	-0.3	0.3	-0.1
Intermittent access total locomotion	0.2	0.2	0.6	-0.8	0.7	-0.0	0.0	0.2
Intermittent access standard deviation	0.1	0.5	0.7	-0.4	0.4	0.8	-0.8	0.8
Left kidney weight	0.2	1.6	1.8	-1.3	1.3	1.2	-1.2	1.3
Right kidney weight	0.9	6.0	6.4	-2.4	2.4	2.5	-2.5	2.5
Cocaine induced anxiety	0.1	0.2	0.3	-0.6	0.5	-0.5	0.5	-0.2
Post-drug Anxiety	0.3	0.3	0.6	-0.1	0.1	-0.8	0.8	-0.6
Baseline Anxiety	0.3	0.5	0.5	0.7	-0.7	-0.6	0.6	-0.7
Tail length	0.8	4.1	7.8	-2.8	2.7	1.2	-1.2	1.6
Length with tail	0.8	3.6	7.0	-2.7	2.6	1.0	-1.0	1.5
Length without tail	0.0	0.2	0.3	-0.6	0.6	0.2	-0.2	0.4
Times rat made contact with spout	3.4	3.9	4.1	1.9	-1.9	-2.0	2.0	-2.0
Lifetime Intake	0.7	0.9	1.7	-1.3	1.3	0.5	-0.5	0.8
Liver weight, left	1.2	2.0	2.6	-1.2	1.2	1.6	-1.6	1.5
Liver weight, right	0.7	1.2	1.8	-0.6	0.7	1.4	-1.3	1.2
Locomotor activity	0.8	1.2	1.8	0.7	-0.7	-1.3	1.3	-1.2
Locomotor testing distance	0.5	1.2	1.7	-1.3	1.3	0.9	-0.9	1.0
Locomotor testing rearing	0.1	0.2	0.6	-0.8	0.7	-0.1	0.1	0.2
Locomotion in novel chamber	1.0	1.3	2.2	-0.3	0.3	1.5	-1.5	1.4
Locomotion in novel chamber post-restriction	1.0	2.9	4.7	2.2	-2.1	-1.2	1.3	-1.5
Fecal boli incidents, locomotor time 1	0.1	0.2	0.2	0.5	-0.5	-0.4	0.4	-0.4
Change in fecal boli incidents, locomotor task	1.5	1.6	1.8	1.2	-1.2	-1.4	1.3	-1.3
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	0.4	-0.4	-0.3	0.3	-0.3
Bouts of movement, locomotor time 1	1.3	1.6	2.1	1.0	-1.0	-1.5	1.5	-1.4
Total resting periods, locomotor time 1	2.2	2.5	2.9	1.4	-1.5	-1.7	1.7	-1.7
Rest time, locomotor task time 1	0.4	0.7	0.7	0.8	-0.8	-0.9	0.9	-0.8
Distance moved, locomotor task time 1	0.4	1.2	1.3	-1.1	1.1	1.0	-1.0	1.1
Vertical activity count, locomotor time 1	0.1	0.4	0.5	-0.7	0.7	0.6	-0.6	0.6
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.2	0.5	-0.5	-0.5	0.4	-0.4
Bouts of movement, locomotor time 2	0.0	0.0	0.0	-0.0	0.0	-0.1	0.1	-0.1
Total resting periods, locomotor time 2	0.0	0.1	0.1	0.2	-0.2	-0.3	0.3	-0.3
Rest time, locomotor task time 2	0.1	0.2	0.3	0.6	-0.6	-0.4	0.4	-0.5
Distance moved, locomotor task time 2	0.0	0.0	0.0	-0.0	0.0	0.1	-0.1	0.1
Vertical activity count, locomotor time 2	0.0	0.1	0.1	-0.3	0.3	0.3	-0.3	0.3
Light reinforcement 1	0.4	1.8	2.0	-1.4	1.4	1.2	-1.2	1.4
Light reinforcement 2	0.7	1.5	1.9	-1.4	1.4	1.1	-1.1	1.2
Bone: marrow area	0.0	0.0	0.0	-0.1	0.1	-0.1	0.1	-0.0
Bone: maximum diameter	0.5	1.0	2.0	-0.1	0.0	-1.4	1.4	-1.0
Bone: maximum force	0.3	0.7	0.9	-1.0	1.0	0.7	-0.7	0.8
Bone: maximum moment	0.6	1.1	1.5	-1.2	1.2	0.9	-0.9	1.0
Mean time between licks in bursts	0.5	2.9	3.6	1.4	-1.5	-1.9	1.9	-1.8
Mean num. licks in bursts	1.3	3.5	5.2	2.3	-2.2	-1.5	1.5	-1.7
Cd content in liver	0.5	0.5	0.8	0.5	-0.5	-0.9	0.9	-0.7
Co content in liver	0.6	0.7	0.9	-1.0	1.0	0.7	-0.7	0.9
Cu content in liver	0.2	0.2	0.3	0.3	-0.3	-0.5	0.5	-0.4
Fe content in liver	0.8	1.0	2.2	1.5	-1.4	-0.5	0.5	-0.7
K content in liver	4.2	4.1	5.9	-2.4	2.4	1.6	-1.6	1.9
Mg content in liver	0.7	0.8	1.1	-1.1	1.0	0.7	-0.7	0.8
Mn content in liver	1.9	2.1	2.5	-1.6	1.6	1.3	-1.3	1.4
Na content in liver	0.3	0.3	0.7	-0.2	0.1	-0.8	0.8	-0.5
Rb content in liver	0.9	1.1	2.2	-1.5	1.4	0.6	-0.6	0.8
Se content in liver	2.4	2.8	4.0	-2.0	2.0	1.3	-1.3	1.6
Sr content in liver	0.7	0.6	1.2	0.0	-0.1	-1.1	1.1	-0.8
Zn content in liver	0.7	0.8	1.1	-1.1	1.0	0.7	-0.8	0.9
Bone: minimum diameter	0.1	0.3	0.3	-0.5	0.5	0.5	-0.5	0.5
Time in familiar zone, hab. session 1	0.0	0.1	0.1	-0.1	0.1	0.3	-0.3	0.2
Time in novel zone, hab. session 1	0.3	0.3	0.6	-0.8	0.8	0.4	-0.4	0.5
Total zone transitions, hab. session 1	0.0	0.1	0.1	0.2	-0.2	-0.3	0.3	-0.3
Total locomotion distance, hab. session 1	0.2	0.3	0.4	-0.6	0.6	0.4	-0.4	0.4
Locomotion velocity, hab. session 1	0.0	0.0	0.1	0.1	-0.1	-0.2	0.2	-0.3
Time in familiar zone, hab. session 2	0.4	0.4	0.9	0.9	-0.9	-0.2	0.2	-0.5
Time in novel zone, hab. session 2	0.6	0.6	1.3	-1.1	1.1	0.3	-0.3	0.6
Total zone transitions, hab. session 2	0.0	0.1	0.1	-0.3	0.3	-0.2	0.2	-0.1
Total locomotion distance, hab. session 2	0.1	0.2	0.3	0.0	-0.0	-0.5	0.5	-0.5
Locomotion velocity, hab. session 2	0.1	0.1	0.2	-0.2	0.1	-0.5	0.5	-0.4
Novel to familiar place preference ratio	0.8	1.0	1.5	0.6	-0.7	-1.2	1.2	-1.0
Novelty place preference	0.8	1.0	1.6	0.6	-0.7	-1.3	1.3	-1.1
Time in novel zone, NPP test	0.7	0.9	1.4	0.6	-0.6	-1.2	1.2	-1.0
Total zone transitions, NPP test	0.5	0.8	1.1	-0.6	0.7	1.0	-1.0	0.9
Total locomotion distance, NPP test	0.2	0.2	0.3	-0.4	0.4	0.6	-0.6	0.4
Locomotion velocity, NPP test	0.1	0.1	0.2	-0.4	0.4	0.4	-0.4	0.3
Intraocular pressure	0.9	1.5	1.8	1.0	-1.0	-1.3	1.3	-1.3
Delta distance traveled before/after self-admin	0.0	0.1	0.1	0.3	-0.3	0.2	-0.2	0.1
Delta ambulatory time before/after self-admin	0.1	0.1	0.1	0.4	-0.3	0.3	-0.3	0.2
Parametrial fat weight	5.0	11.8	15.9	2.6	-2.7	-4.0	4.0	-3.7
Pavlov. Cond. lever latency	0.2	0.3	0.4	0.3	-0.3	-0.7	0.6	-0.5
Pavlov. Cond. magazine entry latency	0.2	0.2	0.3	0.6	-0.5	0.4	-0.4	0.2
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	-0.3	0.2	-0.2	0.2	0.0
Pavlov. Cond. index score	0.3	0.3	0.7	0.1	-0.1	0.8	-0.8	0.6
Pavlov. Cond. latency score	0.2	0.3	0.6	0.1	-0.0	0.8	-0.8	0.6
Pavlov. Cond. lever contacts	0.4	0.4	0.8	-0.2	0.3	0.9	-0.9	0.7
Pavlov. Cond. magazine entry number	0.2	0.2	0.4	-0.7	0.6	-0.4	0.4	-0.2
Pavlov. Cond. intertrial magazine entries	1.2	1.4	2.0	-1.4	1.4	1.0	-1.0	1.1
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.0	0.1	0.0	1.0	-1.0	0.8
Pavlov. Cond. response bias	0.4	0.5	0.9	-0.2	0.3	0.9	-0.9	0.8
Pavlov. Cond. lever latency	2.5	3.5	5.9	-2.4	2.4	1.3	-1.3	1.6
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	0.1	-0.1	0.2	-0.2	0.2
Pavlov. Cond. change in total contacts	0.2	0.5	0.7	0.8	-0.8	-0.6	0.6	-0.6
Pavlov. Cond. index score	0.5	0.8	1.5	1.2	-1.2	-0.5	0.5	-0.7
Pavlov. Cond. latency score	0.3	0.5	1.1	1.1	-1.0	-0.3	0.3	-0.4
Pavlov. Cond. lever contacts	2.0	2.9	5.2	2.3	-2.2	-1.1	1.1	-1.4
Pavlov. Cond. magazine entry number	0.2	0.3	0.4	-0.7	0.7	0.4	-0.5	0.4
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	0.1	-0.2	-0.2	0.1	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.6	1.2	1.1	-1.1	-0.3	0.3	-0.5
Pavlov. Cond. response bias	1.5	2.1	3.4	1.8	-1.8	-1.0	1.0	-1.3
Time in closed arm before self-admin	0.6	1.1	1.4	-1.2	1.2	1.0	-1.0	0.9
Time in closed arm after self-admin	0.5	0.6	1.2	0.0	0.0	1.1	-1.1	0.7
Time in open arm before self-admin	0.1	0.1	0.1	0.3	-0.3	0.2	-0.2	0.3
Time in open arm after self-admin	1.2	1.4	2.2	0.6	-0.7	-1.5	1.5	-1.2
Bone: periosteal estimation	0.2	0.4	0.9	-0.9	0.9	0.2	-0.2	0.5
Bone: periosteal perimeter	0.1	0.2	0.5	-0.7	0.7	-0.2	0.2	0.0
Bone: post-yield work	0.0	0.0	0.1	-0.2	0.2	0.1	-0.1	0.2
Progressive ratio test 1 active lever presses	0.2	0.3	0.7	-0.8	0.8	0.2	-0.2	0.4
Progressive ratio test 1 breakpoint	0.1	0.2	0.5	-0.7	0.7	0.2	-0.2	0.3
Progressive ratio test 1 inactive lever presses	0.2	0.4	0.8	-0.9	0.8	-0.5	0.5	-0.1
Progressive ratio test 2 active lever presses	0.1	0.1	0.4	-0.6	0.6	-0.2	0.2	0.0
Progressive ratio test 2 breakpoint	0.1	0.1	0.2	-0.4	0.4	-0.3	0.3	-0.1
Progressive ratio test 2 inactive lever presses	0.2	0.6	1.2	0.1	-0.1	-1.1	1.1	-0.8
Incentive Sensitization - Responses	0.1	0.3	0.5	0.2	-0.2	-0.7	0.7	-0.7
Incentive Sensitization - Breakpoint	0.1	0.3	0.5	0.3	-0.3	-0.7	0.7	-0.7
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.3	-0.5	0.5	0.4	-0.4	0.5
Progressive ratio	0.1	0.3	0.4	-0.5	0.5	0.6	-0.6	0.6
Food seeking constrained by brief footshock	3.1	3.9	5.7	-2.4	2.3	1.5	-1.5	1.8
Seeking ratio, punishment vs. effort	0.2	0.4	0.7	-0.8	0.8	0.4	-0.4	0.5
Retroperitoneal fat weight	1.2	5.2	6.8	1.8	-1.9	-2.6	2.6	-2.4
Reaction time number correct	0.1	0.3	0.3	0.5	-0.5	-0.6	0.6	-0.5
Reaction time mean minus median	0.4	2.9	4.1	2.0	-2.0	-1.3	1.3	-1.6
Reaction time mean minus median AUC	0.1	0.6	1.2	1.1	-1.1	-0.5	0.4	-0.7
Reaction time num false alarms	1.1	1.9	2.0	-1.4	1.4	1.3	-1.3	1.4
Reaction time num false alarms AUC	1.4	3.1	3.2	-1.8	1.8	1.7	-1.7	1.8
Reaction time trials correct on left	0.1	0.3	0.3	0.5	-0.5	-0.6	0.6	-0.5
Reaction time trials on left	0.1	0.3	0.3	0.5	-0.6	-0.6	0.6	-0.5
Reaction time mean	0.4	0.9	1.4	1.2	-1.2	-0.7	0.6	-0.9
Reaction time mean AUC	0.2	0.6	1.1	1.1	-1.0	-0.4	0.4	-0.7
Median of all reaction times	0.3	0.4	0.6	0.8	-0.8	-0.4	0.4	-0.7
Reaction time omissions	0.1	0.2	0.5	0.7	-0.6	0.2	-0.2	-0.1
Reaction time false alarm rate	2.6	3.6	3.6	-1.9	1.9	1.9	-1.9	1.9
Reaction time premature initiation rate	0.9	1.3	2.4	-0.4	0.4	1.6	-1.6	1.2
Reaction time premature initiations	0.2	0.5	1.0	-0.1	0.1	1.0	-1.0	0.8
Std. dev. reaction times	0.8	2.5	3.6	1.9	-1.9	-1.2	1.2	-1.5
Reaction time trials completed	0.1	0.3	0.3	0.5	-0.6	-0.6	0.6	-0.5
Reaction time trials AUC	0.1	0.2	0.2	0.4	-0.4	-0.5	0.5	-0.4
Run reversals in cocaine runway, females	0.4	0.4	0.8	0.9	-0.9	-0.3	0.3	-0.6
Run reversals in cocaine runway, males	0.2	0.2	0.4	-0.6	0.6	0.3	-0.3	0.4
Latency to leave start box in cocaine runway	0.7	0.9	1.0	-0.9	0.9	0.9	-0.9	1.0
Latency to leave start box in cocaine runway, F	1.5	1.9	2.4	-1.6	1.6	1.2	-1.2	1.3
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	0.5	-0.4	-0.1	0.1	-0.2
Std. dev. time between licks in bursts	0.1	0.3	0.4	0.6	-0.6	-0.5	0.5	-0.5
Total sessions with >9 infusions	2.1	2.6	3.4	-1.3	1.3	1.8	-1.8	1.8
Short access day 1 total inactive lever presses	0.8	1.5	3.2	-1.8	1.7	0.6	-0.6	0.9
Short access day 10 total inactive lever presses	0.0	0.0	0.0	-0.0	0.0	0.0	-0.0	-0.0
Short access day 1 total infusions	1.4	2.7	3.5	-1.3	1.4	1.8	-1.8	1.9
Short access day 10 total infusions	0.8	1.4	1.6	-1.1	1.1	1.2	-1.2	1.3
Short access total infusions	1.9	2.7	3.0	-1.7	1.7	1.5	-1.5	1.7
Short access day 1 locomotion	3.3	5.4	7.2	-1.8	1.9	2.6	-2.6	2.7
Short access day 10 total locomotion	0.6	2.5	3.3	-1.2	1.2	1.8	-1.8	1.8
Short access total locomotion	2.3	3.5	4.5	-1.4	1.4	2.1	-2.1	2.1
One hour access (0.3 mA shock)	0.3	0.3	0.8	-0.9	0.9	-0.0	0.0	0.3
Compulsive drug intake	0.1	0.1	0.2	0.5	-0.4	0.4	-0.4	0.1
One hour access (shock baseline)	0.1	0.3	0.6	-0.7	0.7	-0.3	0.3	0.0
Social response proportion	2.1	2.6	3.4	1.3	-1.3	-1.9	1.9	-1.7
Social responses	1.8	2.3	3.4	1.0	-1.1	-1.8	1.8	-1.6
Social time	0.9	1.4	1.5	1.2	-1.2	-1.2	1.2	-1.2
Soleus weight	1.0	2.9	4.7	-2.2	2.1	1.3	-1.3	1.5
Bone: stiffness	0.0	0.0	0.0	0.1	-0.1	-0.0	-0.0	-0.0
Tibialis anterior weight	0.1	0.2	0.6	-0.7	0.7	-0.3	0.3	0.0
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.1	-0.4	0.4	0.3	-0.3	0.2
Time to tail flick, vehicle, after self-admin	0.0	0.1	0.2	0.3	-0.3	-0.1	0.1	-0.5
Time to tail flick, test, before self-admin	0.5	0.6	0.7	-0.7	0.7	0.8	-0.8	0.8
Time to tail flick, test, after self-admin	0.8	0.8	1.8	-1.4	1.3	0.4	-0.4	0.5
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.3	0.5	-0.5	-0.4	0.4	-0.6
Delta time to tail flick, test, before/after SA	0.5	0.6	0.9	0.3	-0.3	-0.9	0.9	-0.9
Tibia length	1.0	2.8	3.0	-1.7	1.7	1.7	-1.7	1.6
Ambulatory time before self-admin	1.1	3.4	4.2	-2.0	2.0	1.6	-1.6	1.9
Ambulatory time after self-admin	1.5	2.4	2.8	-1.5	1.5	1.6	-1.6	1.7
Bone: tissue strength	0.1	0.1	0.1	0.2	-0.2	-0.3	0.3	-0.3
Total heroin consumption	0.0	0.0	0.0	-0.1	0.1	0.1	-0.1	-0.1
Bone: trabecular number	0.5	0.9	1.0	-0.9	0.9	1.0	-1.0	1.0
Bone: trabecular spacing	0.2	0.3	0.5	0.0	-0.1	-0.7	0.7	-0.6
Bone: trabecular thickness	0.6	0.9	1.4	-0.4	0.5	1.2	-1.2	1.0
Bone: trabecular tissue density	1.3	2.3	2.8	1.7	-1.7	-1.4	1.4	-1.5
Water consumed over 24 hours	0.6	1.1	1.8	0.7	-0.7	-1.3	1.3	-1.1
Number of responses in last shaping day	0.1	0.1	0.2	-0.1	0.1	0.4	-0.4	0.5