Hub : Genes

Nipsnap1

nipsnap homolog 1

chr14:83957714–83981579 (+)

Nipsnap1 RatGTEx page

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	alternative TSS	NM_001100730.1	0.09	0.07	5.2e-05	0.01	0.03	0.03	0.03	7.4e-03	1.3e-04	6.4e-04	4.0e-04
2	Adipose	alternative TSS	XM_006251337.4	0.09	0.07	2.4e-05	0.02	0.04	0.03	0.03	4.3e-03	6.8e-05	2.8e-04	1.7e-04
3	Adipose	gene expression	Nipsnap1	0.49	0.15	2.8e-16	0.11	0.15	0.15	0.14	3.2e-12	2.2e-16	1.2e-16	8.8e-15
4	Adipose	isoform ratio	NM_001100730.1	0.1	0.08	7.8e-05	0.02	0.03	0.04	0.03	3.4e-03	1.9e-04	6.8e-05	1.3e-04
5	Adipose	isoform ratio	XM_006251337.4	0.09	0.07	1.1e-04	0.02	0.03	0.03	0.03	2.5e-03	3.4e-04	1.1e-04	1.9e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.3	0.5	0.7	-0.6	0.6	-0.8	-0.8	0.8
Area under the delay curve	0.2	0.3	0.6	-0.8	0.7	-0.0	0.3	-0.3
BMI with tail	0.1	0.3	0.3	0.5	-0.5	0.5	0.6	-0.6
BMI without tail	0.2	0.7	1.3	-1.1	1.1	-0.7	-0.6	0.6
Body weight	0.2	0.7	1.7	-1.3	1.2	-0.4	0.0	-0.0
Weight adjusted by age	0.7	1.1	1.4	-1.2	1.2	-1.0	-0.8	0.8
Bone surface	0.1	0.2	0.3	-0.5	0.5	-0.4	-0.3	0.3
Bone volume	0.2	0.3	0.4	-0.6	0.6	-0.6	-0.5	0.5
Breakpoint value in progressive ratio session	0.0	0.1	0.1	-0.3	0.3	0.1	0.2	-0.2
Number of licking bursts	0.3	0.5	1.3	-1.1	1.1	-0.4	-0.2	0.2
Context. condit. distance diff. score	0.3	0.3	0.8	0.9	-0.8	-0.0	-0.3	0.3
Locomotion velocity, session 1	4.2	4.6	4.9	2.1	-2.1	2.2	2.1	-2.1
Locomotion distance, session 1	0.5	0.7	1.0	-0.5	0.6	-0.8	-1.0	1.0
Locomotion velocity, session 2	3.0	3.5	3.6	1.9	-1.9	1.9	1.8	-1.8
Locomotion distance, session 2	0.6	0.9	1.7	1.3	-1.3	0.7	0.5	-0.5
Locomotion velocity, session 3	0.4	0.4	0.8	0.1	-0.1	-0.7	-0.9	0.9
Locomotion distance, session 3	0.1	0.1	0.1	-0.3	0.3	-0.4	-0.3	0.3
Stereotopy head waving bouts, day 3	0.2	0.3	0.5	-0.1	0.1	-0.6	-0.7	0.7
Stereotopy head waving duration, day 3	0.2	0.3	0.7	0.8	-0.8	0.2	-0.0	0.0
Locomotion velocity, session 7	0.0	0.0	0.1	0.0	-0.0	0.2	0.2	-0.2
Locomotion distance, session 7	0.4	0.5	0.8	0.9	-0.9	0.7	0.5	-0.5
Stereotopy head waving bouts, day 7	0.0	0.0	0.1	-0.2	0.2	-0.3	-0.2	0.2
Stereotopy head waving duration, day 7	0.5	0.5	0.7	-0.7	0.7	-0.8	-0.8	0.8
Locomotion velocity, session 8	1.5	1.8	2.8	1.7	-1.7	1.2	1.0	-1.0
Locomotion distance, session 8	0.8	1.1	2.9	1.7	-1.6	0.4	-0.2	0.2
Degree of sensitization distance	1.6	1.6	2.7	1.6	-1.6	1.1	0.9	-0.9
Degree of sensitization stereotypy	0.0	0.0	0.1	-0.3	0.3	-0.2	-0.1	0.1
Conditioned locomotion	0.9	1.0	1.6	-0.6	0.6	-1.1	-1.3	1.3
Cocaine response after cond. corrected	0.2	0.2	0.6	-0.8	0.8	-0.1	0.1	-0.1
Cocaine response after cond. not corrected	0.8	0.9	2.0	-1.4	1.4	-0.6	-0.5	0.4
Cocaine response before conditioning	0.3	0.3	0.5	-0.4	0.4	-0.6	-0.7	0.7
Saline control response	0.3	0.4	0.9	0.9	-0.9	0.5	0.4	-0.4
Bone: connectivity density	0.2	0.3	0.5	-0.4	0.4	-0.6	-0.7	0.7
Bone: cortical apparent density	0.1	0.1	0.3	-0.5	0.5	-0.1	-0.0	0.0
Bone: cortical area	0.6	0.9	2.0	-1.4	1.4	-0.7	-0.4	0.4
Bone: cortical porosity	0.2	0.2	0.2	-0.4	0.4	-0.4	-0.4	0.4
Bone: cortical porosity	0.1	0.2	0.2	-0.2	0.3	-0.4	-0.5	0.5
Bone: cortical thickness	1.8	2.9	4.4	-2.1	2.1	-1.6	-1.3	1.3
Bone: cortical thickness	1.5	1.8	2.5	-1.0	1.1	-1.4	-1.6	1.6
Bone: cortical tissue density	0.1	0.1	0.2	-0.5	0.4	-0.0	0.1	-0.1
Condit. Reinf. active minus inactive responses	2.0	2.2	2.7	1.3	-1.3	1.5	1.7	-1.7
Condit. Reinf. active-inactive response ratio	7.0	7.5	7.6	2.7	-2.8	2.7	2.7	-2.7
Condit. Reinf. active responses	0.6	0.8	1.0	0.8	-0.8	0.9	1.0	-1.0
Condit. Reinf. inactive responses	1.4	1.7	1.9	-1.4	1.4	-1.4	-1.2	1.2
Incentive salience index mean	0.7	0.8	1.2	0.6	-0.6	1.0	1.1	-1.1
Condit. Reinf. lever presses	0.1	0.2	0.3	-0.5	0.5	-0.3	-0.3	0.3
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	0.6	-0.6	0.3	0.0	-0.0
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.3	0.5	-0.5	0.5	0.3	-0.3
Condit. Reinf. active responses	0.3	0.4	0.8	0.9	-0.9	0.5	0.3	-0.3
Condit. Reinf. inactive responses	0.5	0.6	1.1	1.0	-1.0	0.7	0.5	-0.5
Condit. Reinf. lever presses	0.1	0.1	0.1	0.2	-0.2	-0.2	-0.4	0.4
Condit. Reinf. lever reinforcers received	0.2	0.3	0.6	0.8	-0.8	0.5	0.2	-0.2
Conditioned reinforcement - actives	0.0	0.1	0.2	-0.4	0.4	-0.1	0.1	-0.1
Conditioned reinforcement - inactives	0.1	0.2	0.3	-0.1	0.1	0.4	0.6	-0.6
Conditioned locomotion	0.3	0.4	1.0	-1.0	0.9	-0.5	-0.3	0.3
Patch foraging indifference point 0 sec	0.3	0.5	1.2	-1.1	1.1	-0.5	-0.2	0.2
Patch foraging indifference point AUC	0.0	0.1	0.1	0.2	-0.2	0.3	0.3	-0.3
Delay disc. indifference point, 0s delay	0.5	0.5	1.1	-1.0	1.0	-0.6	-0.4	0.4
Delay disc. indifference point, 16s delay	0.8	0.9	1.6	0.3	-0.4	1.0	1.3	-1.3
Delay disc. indifference point, 2s delay	2.2	2.5	3.6	-1.9	1.9	-1.5	-1.2	1.2
Delay disc. indifference point, 24s delay	0.3	0.4	0.7	0.2	-0.2	0.7	0.8	-0.8
Delay disc. indifference point, 4s delay	1.1	1.2	2.3	-1.5	1.5	-0.9	-0.6	0.6
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	-0.1	0.1	0.3	0.5	-0.5
Indifference point function ln k	0.4	0.7	0.9	-0.8	0.8	-1.0	-0.9	0.9
Indifference point function log k	0.4	0.7	0.9	-0.8	0.8	-1.0	-0.9	0.9
Patch foraging total patch changes 0 sec	0.2	0.3	0.8	-0.9	0.9	-0.3	0.0	-0.0
Patch foraging total patch changes 12 sec	0.2	0.3	0.6	-0.8	0.7	-0.3	-0.1	0.1
Patch foraging total patch changes 18 sec	1.1	1.6	2.5	0.7	-0.8	1.4	1.6	-1.6
Patch foraging total patch changes 24 sec	0.6	1.1	1.7	1.3	-1.3	1.0	0.7	-0.7
Patch foraging total patch changes 6 sec	0.1	0.2	0.4	-0.6	0.6	-0.1	0.1	-0.1
Patch foraging time to switch 0 sec	0.0	0.0	0.1	0.1	-0.1	-0.1	-0.2	0.2
Patch foraging water rate 0 sec	0.2	0.3	0.6	-0.1	0.0	0.6	0.8	-0.8
Patch foraging water rate 12 sec	0.0	0.0	0.0	0.0	-0.0	-0.0	0.0	-0.0
Patch foraging water rate 18 sec	1.8	2.8	3.0	-1.6	1.6	-1.7	-1.7	1.7
Patch foraging water rate 24 sec	0.7	1.0	1.1	0.9	-0.9	1.0	1.0	-1.0
Patch foraging water rate 6 sec	0.2	0.3	0.6	-0.7	0.7	-0.5	-0.4	0.4
Seeking ratio, delayed vs. immediate footshock	0.0	0.1	0.1	0.2	-0.2	0.3	0.2	-0.2
Distance traveled before self-admin	1.7	2.2	2.5	-1.6	1.6	-1.5	-1.4	1.4
Distance traveled after self-admin	2.9	3.6	4.3	-1.8	1.8	-2.1	-1.9	1.9
Extensor digitorum longus weight	0.6	2.4	5.6	-2.4	2.3	-1.1	-0.4	0.5
Bone: elastic displacement	0.8	0.9	1.2	-0.7	0.7	-1.0	-1.1	1.1
Bone: elastic work	1.9	2.4	2.6	-1.6	1.6	-1.6	-1.5	1.5
Bone: endosteal estimation	0.0	0.0	0.0	-0.2	0.2	-0.0	0.1	-0.1
Bone: endosteal perimeter	0.0	0.1	0.2	-0.2	0.1	0.3	0.4	-0.4
Epididymis fat weight	0.3	1.1	1.6	-1.2	1.2	-1.0	-0.8	0.8
Delta time in closed arm before/after self-admin	0.6	0.6	1.0	1.0	-0.9	-0.3	-0.7	0.7
Delta time in open arm before/after self-admin	0.7	0.7	1.1	-0.7	0.6	0.7	1.1	-1.1
Diff in mean of infusions in LGA sessions	0.0	0.0	0.0	-0.0	0.0	0.1	-0.1	0.1
Delay discount exponential model param	0.2	0.3	0.6	0.8	-0.7	0.1	-0.3	0.3
Extinction: sum of active levers before priming	0.4	0.4	0.6	0.6	-0.6	0.5	0.8	-0.8
Active lever presses in extinction session 6	0.5	0.5	0.6	-0.7	0.7	-0.8	-0.7	0.7
Bone: final force	0.1	0.1	0.2	-0.5	0.5	-0.3	-0.2	0.2
Bone: final moment	0.2	0.3	0.5	-0.7	0.7	-0.5	-0.3	0.3
Food consumed during 24 hour testing period	1.0	1.4	2.2	0.7	-0.7	1.3	1.5	-1.5
Glucose	17.7	27.8	40.4	3.6	-3.8	5.6	6.4	-6.4
Heart weight	1.5	2.4	2.5	1.4	-1.5	1.6	1.6	-1.6
Delay discount hyperbolic model param	0.3	0.4	0.9	1.0	-0.9	0.3	-0.1	0.1
Intermittent access intake day 1-15 change	0.4	0.9	1.5	0.5	-0.5	1.0	1.2	-1.2
Intermittent access intake escalation	0.3	0.7	1.1	0.4	-0.5	0.9	1.1	-1.1
Intermittent access intake escalation 2	0.2	0.2	0.3	0.3	-0.3	0.5	0.5	-0.5
Intermitt. access day 1 inactive lever presses	0.1	0.4	0.6	0.8	-0.7	0.7	0.5	-0.5
Intermitt. access day 15 inactive lever presses	1.3	2.6	3.8	1.0	-1.1	1.8	1.9	-2.0
Intermitt. access escalation Index	1.8	2.5	2.8	1.5	-1.5	1.7	1.6	-1.6
Intermittent access day 1 total infusions	0.7	1.1	1.5	-1.2	1.2	-1.0	-0.8	0.8
Intermittent access day 15 total infusions	0.2	0.3	0.6	-0.8	0.7	-0.1	0.3	-0.3
Intermittent access terminal intake (last 3 days)	0.2	0.3	0.7	-0.8	0.8	-0.2	0.0	-0.0
Intermittent access total infusions	0.4	0.5	1.1	-1.1	1.0	-0.5	-0.2	0.2
Intermittent access day 1 locomotion	0.7	0.9	0.9	-0.9	0.9	-1.0	-1.0	1.0
Intermittent access day 15 total locomotion	0.1	0.2	0.3	-0.5	0.5	0.1	0.3	-0.3
Intermittent access total locomotion	0.2	0.2	0.6	-0.8	0.7	-0.2	0.0	-0.0
Intermittent access standard deviation	0.2	0.5	0.7	-0.4	0.4	-0.8	-0.8	0.8
Left kidney weight	0.4	1.6	1.8	-1.3	1.3	-1.3	-1.2	1.2
Right kidney weight	1.3	6.0	6.3	-2.4	2.4	-2.5	-2.5	2.5
Cocaine induced anxiety	0.1	0.2	0.3	-0.6	0.5	0.2	0.5	-0.4
Post-drug Anxiety	0.3	0.3	0.6	-0.1	0.1	0.6	0.8	-0.8
Baseline Anxiety	0.4	0.5	0.5	0.7	-0.7	0.7	0.7	-0.7
Tail length	1.1	4.1	7.8	-2.8	2.7	-1.6	-1.2	1.2
Length with tail	0.8	3.6	7.0	-2.7	2.6	-1.5	-1.0	1.0
Length without tail	0.1	0.2	0.3	-0.6	0.6	-0.4	-0.2	0.2
LgA early post infusion interval	0.4	0.6	1.1	-1.1	1.0	-0.6	-0.4	0.4
LgA late post infusion interval	1.8	2.2	2.7	1.3	-1.3	1.6	1.6	-1.6
LgA early loading	0.3	0.5	1.3	1.1	-1.1	0.4	-0.0	0.0
LgA late loading	0.5	1.2	1.8	-0.7	0.7	-1.2	-1.3	1.3
LgA early average infusions	1.1	1.4	2.6	1.6	-1.6	1.0	0.7	-0.7
LgA late average infusions	0.0	0.1	0.1	0.4	-0.4	0.1	0.0	0.0
LgA early timeout	2.3	2.5	3.3	1.8	-1.8	1.5	1.3	-1.3
LgA late timeout	0.0	0.1	0.1	-0.0	0.0	-0.2	-0.3	0.3
LgA early titration	0.9	1.3	1.9	1.4	-1.4	1.0	0.8	-0.9
LgA late titration	0.3	0.4	0.6	0.6	-0.6	0.7	0.7	-0.7
LgA total infusion	0.8	1.1	1.8	1.3	-1.3	0.9	0.7	-0.7
Times rat made contact with spout	3.4	3.9	4.0	1.9	-1.9	2.0	2.0	-2.0
Lifetime Intake	0.8	0.9	1.7	-1.3	1.3	-0.8	-0.5	0.5
Liver weight, left	1.2	2.0	2.5	-1.2	1.2	-1.5	-1.6	1.6
Liver weight, right	0.7	1.2	1.8	-0.6	0.7	-1.2	-1.4	1.3
Locomotor activity	0.8	1.2	1.8	0.7	-0.7	1.2	1.3	-1.3
Locomotor testing distance	0.7	1.2	1.7	-1.3	1.3	-1.0	-0.9	0.9
Locomotor testing rearing	0.1	0.2	0.6	-0.8	0.7	-0.2	0.1	-0.1
Locomotion in novel chamber	1.0	1.3	2.2	-0.3	0.3	-1.4	-1.5	1.5
Locomotion in novel chamber post-restriction	1.8	2.9	4.7	2.2	-2.1	1.5	1.2	-1.2
Fecal boli incidents, locomotor time 1	0.1	0.2	0.2	0.5	-0.5	0.4	0.4	-0.4
Change in fecal boli incidents, locomotor task	1.6	1.6	1.8	1.2	-1.2	1.3	1.3	-1.3
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	0.4	-0.4	0.3	0.4	-0.4
Bouts of movement, locomotor time 1	1.4	1.6	2.1	1.0	-1.0	1.4	1.4	-1.4
Total resting periods, locomotor time 1	2.2	2.5	2.8	1.4	-1.5	1.7	1.7	-1.7
Rest time, locomotor task time 1	0.5	0.6	0.7	0.8	-0.8	0.8	0.8	-0.8
Distance moved, locomotor task time 1	0.7	1.1	1.3	-1.1	1.1	-1.1	-0.9	0.9
Vertical activity count, locomotor time 1	0.2	0.4	0.5	-0.7	0.7	-0.6	-0.5	0.5
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.2	0.5	-0.5	0.4	0.5	-0.5
Bouts of movement, locomotor time 2	0.0	0.0	0.0	-0.0	0.0	0.1	0.1	-0.1
Total resting periods, locomotor time 2	0.0	0.1	0.1	0.2	-0.2	0.3	0.3	-0.3
Rest time, locomotor task time 2	0.2	0.2	0.3	0.6	-0.6	0.5	0.4	-0.4
Distance moved, locomotor task time 2	0.0	0.0	0.0	-0.0	0.0	-0.1	-0.1	0.1
Vertical activity count, locomotor time 2	0.1	0.1	0.1	-0.3	0.3	-0.3	-0.3	0.3
Light reinforcement 1	0.7	1.8	2.0	-1.4	1.4	-1.4	-1.2	1.2
Light reinforcement 2	1.0	1.5	1.9	-1.4	1.4	-1.2	-1.1	1.1
Bone: marrow area	0.0	0.0	0.0	-0.1	0.1	0.0	0.1	-0.1
Bone: maximum diameter	0.5	1.0	2.0	-0.1	0.0	1.0	1.4	-1.4
Bone: maximum force	0.4	0.7	0.9	-1.0	1.0	-0.8	-0.7	0.7
Bone: maximum moment	0.6	1.1	1.5	-1.2	1.2	-1.0	-0.9	0.9
Mean time between licks in bursts	1.2	3.0	3.6	1.4	-1.5	1.8	1.9	-1.9
Mean num. licks in bursts	2.3	3.5	5.2	2.3	-2.2	1.7	1.5	-1.5
Cd content in liver	0.5	0.5	0.8	0.5	-0.5	0.7	0.9	-0.9
Co content in liver	0.6	0.7	0.9	-1.0	1.0	-0.9	-0.7	0.7
Cu content in liver	0.2	0.2	0.3	0.3	-0.3	0.4	0.5	-0.5
Fe content in liver	0.9	1.0	2.2	1.5	-1.4	0.7	0.5	-0.5
K content in liver	4.3	4.1	5.9	-2.4	2.4	-1.9	-1.6	1.6
Mg content in liver	0.7	0.7	1.1	-1.1	1.0	-0.8	-0.7	0.7
Mn content in liver	1.9	2.1	2.5	-1.6	1.6	-1.4	-1.3	1.3
Na content in liver	0.3	0.3	0.7	-0.2	0.1	0.5	0.8	-0.8
Rb content in liver	0.9	1.1	2.2	-1.5	1.4	-0.8	-0.6	0.6
Se content in liver	2.4	2.8	4.0	-2.0	2.0	-1.6	-1.3	1.3
Sr content in liver	0.7	0.6	1.2	0.0	-0.1	0.8	1.1	-1.1
Zn content in liver	0.7	0.8	1.1	-1.1	1.0	-0.9	-0.7	0.7
Bone: minimum diameter	0.1	0.3	0.3	-0.5	0.5	-0.5	-0.5	0.5
Time in familiar zone, hab. session 1	0.1	0.0	0.1	-0.1	0.1	-0.2	-0.3	0.3
Time in novel zone, hab. session 1	0.3	0.3	0.6	-0.8	0.8	-0.5	-0.4	0.4
Total zone transitions, hab. session 1	0.0	0.1	0.1	0.2	-0.2	0.3	0.3	-0.3
Total locomotion distance, hab. session 1	0.2	0.3	0.4	-0.6	0.6	-0.4	-0.4	0.4
Locomotion velocity, hab. session 1	0.0	0.0	0.1	0.1	-0.1	0.3	0.2	-0.2
Time in familiar zone, hab. session 2	0.4	0.4	0.9	0.9	-0.9	0.5	0.2	-0.2
Time in novel zone, hab. session 2	0.6	0.6	1.3	-1.1	1.1	-0.6	-0.3	0.3
Total zone transitions, hab. session 2	0.0	0.1	0.1	-0.3	0.3	0.1	0.2	-0.2
Total locomotion distance, hab. session 2	0.1	0.2	0.3	0.0	-0.0	0.5	0.5	-0.5
Locomotion velocity, hab. session 2	0.1	0.1	0.2	-0.2	0.1	0.4	0.4	-0.4
Novel to familiar place preference ratio	0.9	1.0	1.5	0.6	-0.7	1.0	1.2	-1.2
Novelty place preference	1.0	1.0	1.6	0.6	-0.7	1.1	1.2	-1.2
Time in novel zone, NPP test	0.8	0.9	1.4	0.6	-0.6	1.0	1.2	-1.2
Total zone transitions, NPP test	0.5	0.8	1.1	-0.6	0.7	-0.9	-1.1	1.1
Total locomotion distance, NPP test	0.2	0.2	0.3	-0.4	0.4	-0.4	-0.6	0.6
Locomotion velocity, NPP test	0.1	0.1	0.2	-0.4	0.4	-0.3	-0.4	0.4
Intraocular pressure	1.0	1.5	1.8	1.0	-1.0	1.3	1.3	-1.3
Delta distance traveled before/after self-admin	0.0	0.0	0.1	0.3	-0.3	-0.1	-0.2	0.2
Delta ambulatory time before/after self-admin	0.1	0.1	0.1	0.4	-0.3	-0.2	-0.3	0.3
Parametrial fat weight	5.0	11.9	15.9	2.6	-2.7	3.7	4.0	-4.0
Pavlov. Cond. lever latency	0.2	0.3	0.4	0.3	-0.3	0.5	0.7	-0.7
Pavlov. Cond. magazine entry latency	0.2	0.2	0.3	0.6	-0.5	-0.2	-0.4	0.4
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	-0.3	0.2	-0.0	0.2	-0.2
Pavlov. Cond. index score	0.3	0.3	0.7	0.1	-0.1	-0.6	-0.8	0.8
Pavlov. Cond. latency score	0.2	0.3	0.6	0.1	-0.0	-0.6	-0.8	0.8
Pavlov. Cond. lever contacts	0.4	0.4	0.8	-0.2	0.3	-0.7	-0.9	0.9
Pavlov. Cond. magazine entry number	0.2	0.2	0.4	-0.7	0.6	0.2	0.4	-0.4
Pavlov. Cond. intertrial magazine entries	1.2	1.4	2.0	-1.4	1.4	-1.1	-1.0	1.0
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.0	0.1	0.0	-0.8	-1.0	1.0
Pavlov. Cond. response bias	0.4	0.5	0.9	-0.2	0.3	-0.8	-0.9	0.9
Pavlov. Cond. lever latency	2.5	3.5	5.9	-2.4	2.4	-1.6	-1.2	1.2
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	0.1	-0.1	-0.2	-0.2	0.2
Pavlov. Cond. change in total contacts	0.3	0.5	0.7	0.8	-0.8	0.6	0.6	-0.6
Pavlov. Cond. index score	0.6	0.8	1.5	1.2	-1.2	0.7	0.5	-0.5
Pavlov. Cond. latency score	0.4	0.5	1.1	1.1	-1.0	0.4	0.2	-0.2
Pavlov. Cond. lever contacts	2.1	2.9	5.2	2.3	-2.2	1.4	1.0	-1.0
Pavlov. Cond. magazine entry number	0.2	0.3	0.4	-0.7	0.7	-0.4	-0.4	0.4
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	0.1	-0.2	0.2	0.2	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.6	1.2	1.1	-1.1	0.5	0.3	-0.3
Pavlov. Cond. response bias	1.5	2.1	3.4	1.8	-1.8	1.3	1.0	-1.0
LgA PC1 addiction-like behavior	0.2	0.3	0.7	0.8	-0.8	0.4	0.2	-0.2
Time in closed arm before self-admin	0.9	1.1	1.4	-1.2	1.2	-0.9	-1.0	1.0
Time in closed arm after self-admin	0.5	0.6	1.2	0.0	0.0	-0.7	-1.1	1.1
Time in open arm before self-admin	0.1	0.1	0.1	0.3	-0.3	-0.3	-0.2	0.2
Time in open arm after self-admin	1.2	1.3	2.1	0.6	-0.7	1.2	1.5	-1.4
Bone: periosteal estimation	0.2	0.4	0.9	-0.9	0.9	-0.5	-0.2	0.2
Bone: periosteal perimeter	0.1	0.2	0.5	-0.7	0.7	-0.0	0.2	-0.2
Bone: post-yield work	0.0	0.0	0.1	-0.2	0.2	-0.2	-0.1	0.1
Progressive ratio test 1 active lever presses	0.3	0.3	0.7	-0.8	0.8	-0.4	-0.2	0.2
Progressive ratio test 1 breakpoint	0.2	0.2	0.5	-0.7	0.7	-0.3	-0.2	0.2
Progressive ratio test 1 inactive lever presses	0.3	0.4	0.8	-0.9	0.8	0.1	0.5	-0.5
Progressive ratio test 2 active lever presses	0.1	0.1	0.4	-0.6	0.6	-0.0	0.2	-0.2
Progressive ratio test 2 breakpoint	0.1	0.1	0.2	-0.4	0.4	0.1	0.3	-0.3
Progressive ratio test 2 inactive lever presses	0.4	0.6	1.2	0.1	-0.1	0.8	1.1	-1.1
ShA PR total presses	0.3	0.3	0.8	0.9	-0.8	0.0	-0.2	0.2
Incentive Sensitization - Responses	0.2	0.3	0.5	0.2	-0.2	0.7	0.7	-0.7
Incentive Sensitization - Breakpoint	0.2	0.3	0.5	0.3	-0.3	0.7	0.7	-0.7
LgA PR total presses	1.2	1.3	2.1	1.4	-1.4	1.0	0.8	-0.8
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.3	-0.5	0.5	-0.5	-0.4	0.4
Progressive ratio	0.2	0.3	0.4	-0.5	0.5	-0.6	-0.6	0.6
Food seeking constrained by brief footshock	3.1	3.8	5.7	-2.4	2.3	-1.8	-1.5	1.5
Seeking ratio, punishment vs. effort	0.3	0.4	0.7	-0.8	0.8	-0.5	-0.4	0.4
Retroperitoneal fat weight	1.2	5.2	6.8	1.8	-1.9	2.4	2.6	-2.6
Reaction time number correct	0.2	0.3	0.3	0.5	-0.5	0.5	0.6	-0.6
Reaction time mean minus median	1.2	2.9	4.1	2.0	-2.0	1.6	1.4	-1.4
Reaction time mean minus median AUC	0.3	0.7	1.2	1.1	-1.1	0.7	0.5	-0.5
Reaction time num false alarms	1.3	1.9	2.0	-1.4	1.4	-1.4	-1.3	1.3
Reaction time num false alarms AUC	2.0	3.1	3.2	-1.8	1.8	-1.8	-1.7	1.7
Reaction time trials correct on left	0.2	0.3	0.3	0.5	-0.5	0.5	0.6	-0.6
Reaction time trials on left	0.2	0.3	0.3	0.5	-0.6	0.5	0.6	-0.6
Reaction time mean	0.6	0.9	1.4	1.2	-1.2	0.9	0.7	-0.7
Reaction time mean AUC	0.4	0.6	1.1	1.1	-1.0	0.7	0.4	-0.4
Median of all reaction times	0.3	0.4	0.6	0.8	-0.8	0.7	0.4	-0.4
Reaction time omissions	0.1	0.2	0.5	0.7	-0.6	0.1	-0.2	0.2
Reaction time false alarm rate	2.6	3.6	3.6	-1.9	1.9	-1.9	-1.9	1.9
Reaction time premature initiation rate	1.0	1.3	2.4	-0.4	0.4	-1.2	-1.6	1.6
Reaction time premature initiations	0.3	0.5	1.0	-0.1	0.1	-0.8	-1.0	1.0
Std. dev. reaction times	1.4	2.5	3.6	1.9	-1.9	1.5	1.3	-1.3
Reaction time trials completed	0.2	0.3	0.3	0.5	-0.6	0.5	0.6	-0.6
Reaction time trials AUC	0.1	0.2	0.2	0.4	-0.4	0.4	0.5	-0.5
Run reversals in cocaine runway, females	0.4	0.4	0.8	0.9	-0.9	0.6	0.3	-0.3
Run reversals in cocaine runway, males	0.2	0.2	0.4	-0.6	0.6	-0.4	-0.3	0.3
Latency to leave start box in cocaine runway	0.8	0.9	1.0	-0.9	0.9	-1.0	-1.0	1.0
Latency to leave start box in cocaine runway, F	1.7	1.9	2.4	-1.6	1.6	-1.3	-1.2	1.2
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	0.5	-0.4	0.2	0.1	-0.1
Std. dev. time between licks in bursts	0.2	0.3	0.4	0.6	-0.6	0.5	0.5	-0.5
Total sessions with >9 infusions	2.2	2.6	3.4	-1.3	1.3	-1.8	-1.8	1.8
Short access day 1 total inactive lever presses	1.2	1.5	3.2	-1.8	1.7	-0.9	-0.6	0.6
Short access day 10 total inactive lever presses	0.0	0.0	0.0	-0.0	0.0	0.0	-0.0	0.0
Short access day 1 total infusions	2.0	2.7	3.5	-1.3	1.4	-1.9	-1.8	1.8
Short access day 10 total infusions	1.1	1.4	1.6	-1.1	1.1	-1.3	-1.2	1.2
Short access total infusions	2.1	2.7	3.0	-1.7	1.7	-1.7	-1.5	1.5
ShA early post infusion interval	0.5	0.4	1.0	-1.0	1.0	-0.5	-0.2	0.2
ShA late post infusion interval	0.0	0.0	0.1	-0.3	0.3	-0.1	0.1	-0.1
ShA early loading	0.3	0.3	0.5	0.7	-0.7	0.5	0.3	-0.4
ShA late loading	1.3	1.8	3.7	1.9	-1.9	1.0	0.6	-0.6
Short access day 1 locomotion	4.4	5.5	7.2	-1.8	1.9	-2.7	-2.6	2.6
Short access day 10 total locomotion	1.4	2.5	3.3	-1.2	1.2	-1.8	-1.8	1.8
Short access total locomotion	2.9	3.5	4.6	-1.4	1.4	-2.1	-2.1	2.1
ShA early average infusions	2.6	3.1	3.4	1.8	-1.8	1.8	1.7	-1.7
ShA late average infusions	0.2	0.2	0.4	0.6	-0.5	-0.1	-0.4	0.4
ShA early timeout	2.5	2.5	2.7	1.5	-1.5	1.6	1.6	-1.6
ShA late timeout	0.2	0.2	0.6	0.8	-0.7	0.3	0.0	-0.0
ShA early titration	1.8	1.9	2.3	1.5	-1.5	1.4	1.3	-1.3
ShA late titration	0.3	0.3	0.8	0.9	-0.9	0.2	-0.2	0.2
ShA total infusions	0.9	1.1	2.3	1.5	-1.5	0.8	0.4	-0.4
One hour access (0.3 mA shock)	0.3	0.3	0.8	-0.9	0.9	-0.3	0.0	-0.0
Shock compulsivity	0.3	0.7	1.1	-0.4	0.4	-0.8	-1.1	1.1
Compulsive drug intake	0.1	0.1	0.2	0.5	-0.4	-0.1	-0.4	0.4
One hour access (shock baseline)	0.2	0.3	0.6	-0.7	0.7	-0.0	0.3	-0.3
Social response proportion	2.3	2.6	3.4	1.3	-1.3	1.7	1.9	-1.9
Social responses	1.8	2.3	3.4	1.0	-1.1	1.6	1.8	-1.8
Social time	1.1	1.4	1.5	1.2	-1.2	1.2	1.2	-1.2
Soleus weight	1.0	2.9	4.7	-2.2	2.1	-1.5	-1.3	1.3
Bone: stiffness	0.0	0.0	0.0	0.1	-0.1	0.0	0.0	-0.0
Tibialis anterior weight	0.1	0.2	0.6	-0.7	0.7	-0.0	0.3	-0.3
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.1	-0.4	0.4	-0.2	-0.3	0.3
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.2	0.3	-0.3	0.5	0.1	-0.1
Time to tail flick, test, before self-admin	0.6	0.6	0.7	-0.7	0.7	-0.8	-0.7	0.7
Time to tail flick, test, after self-admin	0.8	0.8	1.8	-1.4	1.3	-0.5	-0.4	0.4
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.3	0.5	-0.5	0.6	0.4	-0.4
Delta time to tail flick, test, before/after SA	0.6	0.6	0.9	0.3	-0.3	0.9	0.9	-0.9
Tibia length	1.0	2.8	3.0	-1.7	1.7	-1.6	-1.7	1.7
Ambulatory time before self-admin	2.3	3.4	4.2	-2.0	2.0	-1.9	-1.6	1.6
Ambulatory time after self-admin	2.0	2.4	2.8	-1.5	1.5	-1.7	-1.6	1.5
Bone: tissue strength	0.1	0.1	0.1	0.2	-0.2	0.3	0.3	-0.3
Total heroin consumption	0.0	0.0	0.0	-0.1	0.1	0.1	-0.1	0.1
Total infusions	0.8	1.0	1.8	1.4	-1.3	0.9	0.6	-0.6
Bone: trabecular number	0.6	1.0	1.0	-0.9	0.9	-1.0	-1.0	1.0
Bone: trabecular spacing	0.2	0.3	0.5	0.0	-0.1	0.6	0.7	-0.7
Bone: trabecular thickness	0.7	0.9	1.4	-0.4	0.5	-1.0	-1.2	1.2
Bone: trabecular tissue density	1.6	2.3	2.8	1.7	-1.7	1.5	1.4	-1.4
Water consumed over 24 hours	0.8	1.1	1.7	0.7	-0.7	1.1	1.3	-1.3
Number of responses in last shaping day	0.1	0.1	0.2	-0.1	0.1	-0.5	-0.4	0.4