Ngp

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Ngp 0.35 0.23 0.0e+00 0.22 0.24 0.25 0.25 6.1e-25 1.8e-27 8.3e-29 3.5e-28
2 pVTA gene expression Ngp 0.33 0.2 4.9e-11 0.14 0.21 0.18 0.22 1.5e-06 2.0e-09 3.6e-08 8.8e-10
3 BLA gene expression Ngp 0.05 0.05 9.8e-03 0.01 0.03 0.03 0.02 6.8e-02 9.3e-03 1.5e-02 4.0e-02
4 PL gene expression Ngp 0.11 0.09 1.4e-10 0.07 0.09 0.07 0.07 4.4e-08 8.4e-10 1.2e-08 1.6e-08
5 NAcc alternative TSS NM_001106862.1 0.02 0.02 4.5e-03 0.04 0.01 0.02 0.03 6.1e-05 6.2e-03 5.5e-03 1.3e-04
6 Brain gene expression Ngp 0.16 0.1 1.1e-16 0.18 0.18 0.18 0.18 1.4e-16 7.4e-17 1.5e-16 2.5e-16
7 Adipose gene expression Ngp 0.02 0.02 4.3e-03 0.01 0.01 0.02 0.02 1.1e-02 1.6e-02 1.0e-03 2.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bone: apparent density0.00.00.00.2-0.1-0.2-0.20.1-0.2-0.2
Area under the delay curve2.32.42.8-1.61.61.51.5-1.51.5-1.7
BMI with tail0.31.11.71.2-0.8-1.0-1.01.0-0.91.3
BMI without tail1.63.43.92.0-1.8-1.9-1.81.8-1.81.7
Body weight6.828.632.15.7-5.3-5.3-5.35.2-5.25.3
Weight adjusted by age0.10.20.20.4-0.5-0.5-0.50.2-0.50.1
Bone surface0.10.10.3-0.30.30.30.3-0.50.3-0.5
Bone volume0.00.00.2-0.10.20.10.1-0.30.1-0.4
Breakpoint value in progressive ratio session0.40.41.20.6-0.4-0.3-0.31.1-0.30.9
Number of licking bursts0.10.10.2-0.40.40.50.4-0.20.4-0.0
Context. condit. distance diff. score0.00.00.0-0.0-0.0-0.0-0.0-0.1-0.0-0.0
Locomotion velocity, session 10.10.10.2-0.30.40.30.3-0.40.3-0.4
Locomotion distance, session 10.70.81.21.1-0.8-1.0-0.90.8-0.90.8
Locomotion velocity, session 20.30.40.5-0.60.70.60.6-0.60.6-0.6
Locomotion distance, session 20.10.10.3-0.20.40.20.2-0.40.2-0.5
Locomotion velocity, session 30.00.00.10.2-0.1-0.3-0.2-0.0-0.2-0.3
Locomotion distance, session 31.41.52.2-1.11.31.11.1-1.31.1-1.5
Stereotopy head waving bouts, day 30.10.10.40.2-0.3-0.2-0.20.4-0.20.6
Stereotopy head waving duration, day 30.30.40.50.6-0.7-0.5-0.60.6-0.60.7
Locomotion velocity, session 70.20.20.30.4-0.5-0.5-0.50.3-0.5-0.1
Locomotion distance, session 70.91.12.0-1.01.00.90.9-1.10.9-1.4
Stereotopy head waving bouts, day 70.00.00.1-0.20.20.20.2-0.20.2-0.2
Stereotopy head waving duration, day 70.30.30.30.6-0.6-0.6-0.60.5-0.50.5
Locomotion velocity, session 80.10.10.30.5-0.3-0.4-0.40.3-0.40.2
Locomotion distance, session 80.10.10.20.5-0.3-0.5-0.40.1-0.4-0.1
Degree of sensitization distance1.51.51.71.2-1.3-1.2-1.21.2-1.21.2
Degree of sensitization stereotypy0.00.00.00.1-0.2-0.2-0.20.1-0.20.0
Conditioned locomotion3.23.74.2-2.01.91.91.9-1.91.9-2.0
Cocaine response after cond. corrected0.40.41.00.6-0.6-0.5-0.50.7-0.51.0
Cocaine response after cond. not corrected2.12.33.11.5-1.5-1.4-1.41.5-1.41.8
Cocaine response before conditioning0.91.11.41.2-1.0-1.2-1.10.9-1.10.7
Saline control response1.41.82.11.4-1.5-1.4-1.41.3-1.41.1
Bone: connectivity density0.20.40.9-0.60.50.50.5-0.60.5-0.9
Bone: cortical apparent density0.30.40.5-0.70.60.50.5-0.60.5-0.7
Bone: cortical area0.10.20.2-0.50.40.40.4-0.50.4-0.2
Bone: cortical porosity0.00.00.2-0.20.10.10.1-0.10.1-0.4
Bone: cortical porosity0.20.20.5-0.40.30.40.4-0.40.3-0.7
Bone: cortical thickness0.10.20.50.4-0.4-0.4-0.40.4-0.40.7
Bone: cortical thickness0.00.00.00.1-0.1-0.1-0.10.1-0.10.1
Bone: cortical tissue density0.30.40.5-0.70.60.50.5-0.60.5-0.7
Condit. Reinf. active minus inactive responses0.10.10.20.3-0.4-0.3-0.40.4-0.40.4
Condit. Reinf. active-inactive response ratio0.30.30.50.5-0.6-0.5-0.50.6-0.60.7
Condit. Reinf. active responses0.00.00.0-0.20.00.10.1-0.10.1-0.0
Condit. Reinf. inactive responses0.60.70.9-0.90.80.90.9-0.90.8-0.8
Incentive salience index mean0.10.10.1-0.30.30.30.3-0.30.3-0.3
Condit. Reinf. lever presses1.72.32.6-1.51.61.51.5-1.61.5-1.5
Condit. Reinf. active minus inactive responses2.22.73.21.8-1.6-1.6-1.61.7-1.61.7
Condit. Reinf. active-inactive response ratio1.92.02.51.5-1.3-1.3-1.31.5-1.31.6
Condit. Reinf. active responses1.92.62.91.7-1.5-1.6-1.61.6-1.61.7
Condit. Reinf. inactive responses0.00.00.1-0.20.20.10.1-0.30.1-0.3
Condit. Reinf. lever presses2.63.54.12.0-1.8-1.8-1.81.9-1.81.9
Condit. Reinf. lever reinforcers received2.02.93.31.8-1.6-1.7-1.71.7-1.71.7
Conditioned reinforcement - actives0.40.40.6-0.70.80.70.7-0.50.7-0.5
Conditioned reinforcement - inactives0.91.01.1-1.11.01.01.0-1.01.0-0.8
Conditioned locomotion0.40.50.7-0.70.80.70.7-0.60.7-0.7
Patch foraging indifference point 0 sec0.91.41.71.3-1.2-1.3-1.31.0-1.30.7
Patch foraging indifference point AUC0.10.10.20.4-0.3-0.3-0.30.5-0.30.4
Delay disc. indifference point, 0s delay0.00.00.1-0.20.30.20.2-0.10.2-0.1
Delay disc. indifference point, 16s delay1.31.42.1-1.21.11.01.0-1.31.0-1.4
Delay disc. indifference point, 2s delay0.40.40.6-0.60.60.60.6-0.60.6-0.8
Delay disc. indifference point, 24s delay1.11.01.6-1.01.00.90.9-1.10.9-1.3
Delay disc. indifference point, 4s delay2.32.42.6-1.61.61.51.5-1.51.5-1.6
Delay disc. indifference point, 8s delay2.32.32.7-1.61.51.51.5-1.51.5-1.6
Indifference point function ln k0.40.50.9-0.60.70.50.6-1.00.6-1.0
Indifference point function log k0.40.50.9-0.60.70.50.6-1.00.6-1.0
Patch foraging total patch changes 0 sec1.11.72.01.4-1.3-1.4-1.41.1-1.41.0
Patch foraging total patch changes 12 sec1.01.31.51.2-1.2-1.2-1.21.1-1.20.9
Patch foraging total patch changes 18 sec2.73.53.91.9-1.9-1.8-1.82.0-1.81.8
Patch foraging total patch changes 24 sec3.44.14.62.1-2.0-2.0-2.02.0-2.02.0
Patch foraging total patch changes 6 sec0.10.20.20.5-0.4-0.5-0.50.3-0.50.2
Patch foraging time to switch 0 sec0.10.10.2-0.40.30.40.4-0.40.4-0.2
Patch foraging water rate 0 sec0.10.20.20.5-0.4-0.4-0.40.4-0.40.4
Patch foraging water rate 12 sec0.30.50.70.7-0.5-0.6-0.60.7-0.60.8
Patch foraging water rate 18 sec0.00.00.00.2-0.0-0.1-0.1-0.0-0.10.2
Patch foraging water rate 24 sec0.81.11.31.1-1.0-1.0-1.01.1-1.01.2
Patch foraging water rate 6 sec0.20.40.50.7-0.6-0.7-0.60.5-0.60.5
Seeking ratio, delayed vs. immediate footshock2.22.53.2-1.51.71.81.8-1.21.8-1.1
Distance traveled before self-admin0.10.10.5-0.2-0.0-0.0-0.0-0.7-0.1-0.4
Distance traveled after self-admin0.40.51.1-0.70.60.50.5-1.10.5-0.9
Extensor digitorum longus weight0.20.60.8-0.80.90.80.8-0.70.8-0.6
Bone: elastic displacement0.10.10.20.3-0.3-0.2-0.20.3-0.20.5
Bone: elastic work0.50.60.80.9-0.8-0.8-0.70.7-0.70.9
Bone: endosteal estimation0.10.10.20.4-0.4-0.4-0.40.3-0.40.1
Bone: endosteal perimeter1.42.93.3-1.71.81.61.6-1.81.6-1.8
Epididymis fat weight0.51.12.21.0-1.0-0.8-0.81.3-0.81.5
Delta time in closed arm before/after self-admin0.10.10.1-0.20.30.40.4-0.00.40.0
Delta time in open arm before/after self-admin0.20.20.30.2-0.4-0.5-0.5-0.4-0.5-0.5
Diff in mean of infusions in LGA sessions0.00.00.20.0-0.00.10.10.20.10.5
Delay discount exponential model param2.72.83.01.7-1.7-1.7-1.61.6-1.61.7
Extinction: sum of active levers before priming0.00.00.10.2-0.1-0.1-0.10.3-0.10.2
Active lever presses in extinction session 60.20.20.30.3-0.4-0.5-0.5-0.2-0.5-0.4
Bone: final force0.91.41.71.2-1.2-1.2-1.21.1-1.11.3
Bone: final moment1.21.92.31.4-1.4-1.3-1.31.3-1.31.5
Food consumed during 24 hour testing period1.41.71.91.4-1.3-1.3-1.31.2-1.31.2
Glucose0.30.40.60.8-0.6-0.7-0.60.7-0.60.6
Heart weight2.84.05.12.1-1.9-1.9-1.91.9-1.92.3
Delay discount hyperbolic model param2.62.83.01.7-1.7-1.6-1.61.6-1.61.7
Intermittent access intake day 1-15 change0.70.70.9-0.90.80.80.8-0.90.8-0.7
Intermittent access intake escalation0.60.60.8-0.80.70.70.7-0.90.7-0.7
Intermittent access intake escalation 20.00.00.0-0.0-0.1-0.1-0.1-0.2-0.1-0.0
Intermitt. access day 1 inactive lever presses0.00.00.0-0.10.00.00.0-0.20.1-0.2
Intermitt. access day 15 inactive lever presses0.70.70.8-0.90.80.80.9-0.90.8-0.8
Intermitt. access escalation Index0.00.00.2-0.10.0-0.0-0.0-0.2-0.0-0.5
Intermittent access day 1 total infusions0.00.00.1-0.20.20.20.2-0.20.2-0.2
Intermittent access day 15 total infusions0.50.50.7-0.80.70.60.7-0.80.6-0.8
Intermittent access terminal intake (last 3 days)0.30.30.6-0.60.50.40.4-0.70.4-0.7
Intermittent access total infusions0.70.81.1-0.90.90.80.8-1.00.8-1.0
Intermittent access day 1 locomotion0.10.10.1-0.40.40.40.4-0.30.4-0.4
Intermittent access day 15 total locomotion0.80.91.4-0.90.90.80.8-1.00.8-1.2
Intermittent access total locomotion1.41.72.1-1.31.31.21.2-1.31.2-1.4
Intermittent access standard deviation0.20.20.20.4-0.5-0.4-0.40.3-0.40.5
Left kidney weight0.61.82.31.5-1.2-1.4-1.41.2-1.41.2
Right kidney weight0.10.30.50.6-0.4-0.7-0.60.3-0.60.1
Cocaine induced anxiety0.60.60.7-0.90.80.80.8-0.90.8-0.7
Post-drug Anxiety0.20.20.2-0.50.40.50.5-0.40.5-0.3
Baseline Anxiety0.10.20.2-0.40.30.40.4-0.40.4-0.5
Tail length7.221.924.34.9-4.9-4.7-4.74.6-4.74.3
Length with tail10.036.540.16.3-6.3-6.1-6.15.8-6.15.7
Length without tail6.814.916.44.1-3.9-3.8-3.83.8-3.83.9
Times rat made contact with spout0.50.60.70.7-0.8-0.7-0.70.7-0.70.8
Lifetime Intake0.50.50.7-0.80.80.70.7-0.80.7-0.8
Liver weight, left0.10.10.20.3-0.4-0.3-0.30.3-0.30.0
Liver weight, right1.32.22.51.6-1.6-1.5-1.51.5-1.51.3
Locomotor activity5.58.89.43.1-3.0-3.0-3.02.8-3.02.8
Locomotor testing distance5.38.89.73.1-3.0-3.0-3.02.9-3.02.7
Locomotor testing rearing0.20.30.30.5-0.6-0.5-0.50.6-0.60.5
Locomotion in novel chamber0.10.20.3-0.40.50.50.5-0.20.50.2
Locomotion in novel chamber post-restriction0.91.11.71.1-0.9-1.0-1.01.1-0.91.3
Fecal boli incidents, locomotor time 10.50.61.10.8-0.7-0.6-0.60.8-0.61.0
Change in fecal boli incidents, locomotor task0.10.10.30.3-0.2-0.1-0.10.5-0.10.5
Time >=10cm from walls, locomotor time 10.10.10.2-0.30.30.30.3-0.30.3-0.4
Bouts of movement, locomotor time 10.10.10.10.2-0.3-0.1-0.10.3-0.10.3
Total resting periods, locomotor time 10.10.10.20.2-0.3-0.1-0.10.4-0.10.4
Rest time, locomotor task time 10.40.40.7-0.60.60.80.8-0.30.8-0.2
Distance moved, locomotor task time 11.61.81.91.4-1.3-1.4-1.41.2-1.41.2
Vertical activity count, locomotor time 10.90.91.01.0-0.9-1.0-1.00.9-1.01.0
Time >=10cm from walls, locomotor time 21.71.82.01.4-1.3-1.3-1.31.3-1.31.3
Bouts of movement, locomotor time 20.00.00.00.1-0.1-0.0-0.00.0-0.00.1
Total resting periods, locomotor time 20.00.10.1-0.20.20.30.3-0.20.2-0.2
Rest time, locomotor task time 20.00.00.1-0.10.00.20.20.10.20.2
Distance moved, locomotor task time 20.91.01.31.0-1.0-1.1-1.10.8-1.10.8
Vertical activity count, locomotor time 20.10.10.10.2-0.2-0.3-0.30.1-0.3-0.0
Light reinforcement 10.71.31.41.2-1.1-1.2-1.11.2-1.11.1
Light reinforcement 20.10.20.5-0.30.40.30.3-0.50.3-0.7
Bone: marrow area0.10.20.20.4-0.4-0.4-0.40.4-0.40.2
Bone: maximum diameter0.40.80.9-1.01.00.90.9-1.00.9-0.7
Bone: maximum force0.71.21.41.1-1.2-1.1-1.11.0-1.11.1
Bone: maximum moment0.81.41.51.2-1.2-1.2-1.21.1-1.21.2
Mean time between licks in bursts1.21.72.0-1.31.41.31.3-1.31.3-1.2
Mean num. licks in bursts0.50.60.80.8-0.8-0.9-0.90.6-0.90.5
Cd content in liver2.83.03.81.7-1.8-1.6-1.61.8-1.71.9
Co content in liver0.00.00.1-0.0-0.1-0.0-0.0-0.2-0.1-0.3
Cu content in liver4.55.46.02.4-2.3-2.2-2.22.4-2.22.4
Fe content in liver2.22.63.61.6-1.7-1.4-1.51.8-1.51.9
K content in liver0.80.81.01.0-0.8-0.9-0.80.9-0.81.0
Mg content in liver0.00.00.00.10.10.00.1-0.10.1-0.0
Mn content in liver0.40.50.70.9-0.7-0.8-0.80.5-0.80.2
Na content in liver0.40.40.60.6-0.8-0.6-0.70.7-0.70.5
Rb content in liver1.41.72.21.2-1.5-1.1-1.21.4-1.31.4
Se content in liver0.10.10.20.2-0.2-0.2-0.20.3-0.20.4
Sr content in liver0.00.00.00.10.1-0.00.0-0.10.0-0.1
Zn content in liver4.75.25.92.4-2.2-2.2-2.22.3-2.22.4
Bone: minimum diameter0.40.81.0-0.90.90.80.8-1.00.8-1.0
Time in familiar zone, hab. session 11.31.21.5-1.21.11.21.1-1.11.1-0.9
Time in novel zone, hab. session 10.60.60.70.8-0.8-0.8-0.80.6-0.80.6
Total zone transitions, hab. session 10.40.50.80.9-0.7-0.9-0.80.5-0.80.4
Total locomotion distance, hab. session 10.20.30.40.6-0.5-0.6-0.50.5-0.50.5
Locomotion velocity, hab. session 10.20.30.40.6-0.5-0.6-0.60.5-0.60.4
Time in familiar zone, hab. session 20.50.50.6-0.70.80.80.8-0.70.8-0.5
Time in novel zone, hab. session 20.00.00.00.1-0.2-0.2-0.20.0-0.2-0.1
Total zone transitions, hab. session 20.00.00.10.2-0.0-0.2-0.2-0.1-0.1-0.1
Total locomotion distance, hab. session 20.20.30.40.7-0.5-0.6-0.50.6-0.50.6
Locomotion velocity, hab. session 20.20.20.30.6-0.4-0.5-0.40.5-0.40.4
Novel to familiar place preference ratio0.70.70.90.9-0.8-0.9-0.90.8-0.90.4
Novelty place preference0.70.70.90.9-0.8-0.9-0.90.7-0.90.3
Time in novel zone, NPP test0.91.01.21.1-1.0-1.1-1.10.9-1.10.5
Total zone transitions, NPP test1.72.53.41.8-1.5-1.7-1.61.4-1.61.2
Total locomotion distance, NPP test0.91.31.61.3-1.1-1.1-1.11.1-1.11.1
Locomotion velocity, NPP test1.01.31.71.3-1.1-1.2-1.21.1-1.11.1
Intraocular pressure1.31.82.11.3-1.4-1.2-1.31.5-1.31.4
Delta distance traveled before/after self-admin0.20.20.4-0.50.50.40.4-0.50.4-0.6
Delta ambulatory time before/after self-admin0.20.20.30.5-0.5-0.5-0.50.4-0.50.3
Parametrial fat weight1.12.22.41.5-1.5-1.5-1.51.4-1.51.3
Pavlov. Cond. lever latency5.67.18.22.7-2.9-2.7-2.72.6-2.72.4
Pavlov. Cond. magazine entry latency7.09.19.9-3.13.13.03.0-3.03.0-2.7
Pavlov. Cond. change in total contacts1.71.82.1-1.41.41.41.4-1.21.4-1.0
Pavlov. Cond. index score6.98.89.8-3.13.13.03.0-2.93.0-2.6
Pavlov. Cond. latency score6.88.79.7-3.03.13.03.0-2.93.0-2.6
Pavlov. Cond. lever contacts3.33.94.6-2.02.22.02.0-1.92.0-1.7
Pavlov. Cond. magazine entry number8.09.910.93.3-3.3-3.2-3.23.1-3.22.8
Pavlov. Cond. intertrial magazine entries0.40.50.60.7-0.8-0.7-0.70.7-0.70.5
Pavlov. Cond. lever-magazine prob. diff.6.17.58.5-2.82.92.82.8-2.72.8-2.3
Pavlov. Cond. response bias7.59.110.2-3.13.23.13.1-2.93.1-2.6
Pavlov. Cond. lever latency0.40.50.7-0.80.70.70.7-0.70.7-0.7
Pavlov. Cond. magazine entry latency0.10.20.3-0.30.50.40.4-0.40.4-0.3
Pavlov. Cond. change in total contacts2.53.44.12.0-1.8-1.8-1.81.8-1.81.9
Pavlov. Cond. index score0.10.10.20.4-0.2-0.3-0.20.3-0.20.4
Pavlov. Cond. latency score0.00.00.10.3-0.1-0.2-0.10.2-0.10.3
Pavlov. Cond. lever contacts1.01.31.71.3-1.1-1.1-1.11.1-1.11.1
Pavlov. Cond. magazine entry number0.40.50.70.6-0.8-0.7-0.70.7-0.80.6
Pavlov. Cond. intertrial magazine entries0.40.50.7-0.80.60.70.6-0.80.6-0.9
Pavlov. Cond. lever-magazine prob. diff.0.00.10.10.4-0.1-0.2-0.20.2-0.20.4
Pavlov. Cond. response bias0.00.10.10.4-0.1-0.2-0.20.2-0.20.3
Time in closed arm before self-admin1.41.61.81.3-1.3-1.4-1.41.0-1.31.1
Time in closed arm after self-admin0.10.10.50.3-0.1-0.1-0.10.6-0.10.7
Time in open arm before self-admin1.01.11.2-1.11.01.11.1-0.91.1-0.9
Time in open arm after self-admin0.70.82.3-0.80.50.40.4-1.30.4-1.5
Bone: periosteal estimation0.00.00.00.1-0.1-0.1-0.1-0.0-0.1-0.0
Bone: periosteal perimeter1.42.32.6-1.61.51.41.4-1.61.4-1.5
Bone: post-yield work0.00.00.00.2-0.1-0.2-0.20.1-0.20.0
Progressive ratio test 1 active lever presses0.00.00.1-0.20.20.10.1-0.10.1-0.3
Progressive ratio test 1 breakpoint0.10.10.1-0.30.30.20.2-0.20.2-0.3
Progressive ratio test 1 inactive lever presses0.30.40.5-0.70.70.70.7-0.50.7-0.3
Progressive ratio test 2 active lever presses1.21.21.4-1.21.21.11.1-1.11.1-1.2
Progressive ratio test 2 breakpoint0.91.11.2-1.11.11.01.0-1.01.0-1.1
Progressive ratio test 2 inactive lever presses2.42.73.1-1.81.71.61.6-1.71.6-1.5
Incentive Sensitization - Responses1.81.82.1-1.41.41.31.3-1.31.3-1.3
Incentive Sensitization - Breakpoint1.81.82.0-1.41.41.31.3-1.31.3-1.3
Sum of active levers in priming session hrs 5-60.40.40.60.7-0.8-0.7-0.70.5-0.70.4
Progressive ratio3.74.34.72.2-2.1-2.0-2.02.1-2.02.2
Food seeking constrained by brief footshock1.01.21.7-1.11.11.01.0-1.31.0-1.3
Seeking ratio, punishment vs. effort6.17.58.1-2.82.92.62.6-2.82.6-2.8
Retroperitoneal fat weight0.62.02.21.5-1.5-1.5-1.51.3-1.51.2
Reaction time number correct0.40.60.8-0.80.80.70.7-0.90.7-0.9
Reaction time mean minus median0.10.10.10.3-0.2-0.2-0.20.4-0.20.4
Reaction time mean minus median AUC0.30.40.60.6-0.5-0.5-0.50.8-0.50.8
Reaction time num false alarms0.40.50.9-0.70.70.60.6-0.80.6-0.9
Reaction time num false alarms AUC0.10.20.5-0.40.30.20.2-0.50.2-0.7
Reaction time trials correct on left0.40.60.8-0.80.80.70.7-0.90.7-0.9
Reaction time trials on left0.50.70.9-0.90.80.70.7-0.90.7-0.9
Reaction time mean0.00.00.00.1-0.1-0.1-0.10.2-0.10.1
Reaction time mean AUC0.00.00.0-0.0-0.00.0-0.00.1-0.0-0.0
Median of all reaction times0.00.00.00.0-0.2-0.1-0.10.1-0.1-0.0
Reaction time omissions0.20.20.4-0.60.40.50.5-0.30.5-0.3
Reaction time false alarm rate0.00.00.1-0.20.10.10.1-0.20.1-0.4
Reaction time premature initiation rate2.23.03.21.8-1.7-1.7-1.71.8-1.71.7
Reaction time premature initiations0.91.31.51.2-1.1-1.2-1.21.1-1.21.0
Std. dev. reaction times0.10.10.20.3-0.3-0.3-0.30.4-0.30.3
Reaction time trials completed0.50.70.9-0.90.80.70.7-0.90.7-0.9
Reaction time trials AUC0.60.81.0-1.00.90.80.8-1.00.8-1.0
Run reversals in cocaine runway, females1.91.92.2-1.51.21.31.3-1.51.3-1.5
Run reversals in cocaine runway, males0.70.70.90.8-0.9-0.8-0.80.8-0.80.9
Latency to leave start box in cocaine runway0.60.61.10.8-0.8-0.6-0.60.9-0.61.1
Latency to leave start box in cocaine runway, F1.41.62.11.3-1.2-1.2-1.21.2-1.21.4
Latency to leave start box in cocaine runway, M0.20.20.3-0.30.20.60.5-0.10.6-0.1
Std. dev. time between licks in bursts4.15.05.5-2.32.32.32.3-2.22.3-1.9
Total sessions with >9 infusions0.10.10.1-0.20.30.30.30.10.30.3
Short access day 1 total inactive lever presses3.64.04.5-2.12.12.12.1-1.82.1-1.7
Short access day 10 total inactive lever presses0.00.00.10.0-0.10.10.10.00.10.2
Short access day 1 total infusions0.70.81.0-0.91.01.01.0-0.61.0-0.5
Short access day 10 total infusions0.10.10.2-0.30.40.30.3-0.40.3-0.4
Short access total infusions0.60.60.7-0.80.90.80.8-0.70.8-0.8
Short access day 1 locomotion0.00.00.1-0.20.30.20.3-0.10.30.0
Short access day 10 total locomotion0.00.00.00.1-0.1-0.1-0.10.2-0.10.2
Short access total locomotion0.00.00.0-0.10.20.10.10.00.1-0.0
One hour access (0.3 mA shock)0.30.40.8-0.60.50.40.4-0.70.4-0.9
Compulsive drug intake0.00.00.2-0.10.00.10.1-0.10.0-0.4
One hour access (shock baseline)0.20.20.3-0.50.40.30.3-0.50.3-0.6
Social response proportion0.50.50.70.7-0.8-0.8-0.80.6-0.80.5
Social responses0.30.40.50.6-0.7-0.7-0.70.5-0.70.4
Social time0.50.71.0-0.90.70.70.7-1.00.7-1.0
Soleus weight4.011.813.53.7-3.5-3.4-3.33.4-3.33.4
Bone: stiffness0.10.20.30.4-0.5-0.5-0.50.4-0.50.3
Tibialis anterior weight0.00.00.10.2-0.1-0.1-0.10.2-0.10.3
Time to tail flick, vehicle, before self-admin2.82.94.21.8-1.8-1.4-1.41.9-1.42.0
Time to tail flick, vehicle, after self-admin0.40.40.60.6-0.7-0.8-0.80.1-0.80.3
Time to tail flick, test, before self-admin0.10.10.10.3-0.2-0.3-0.30.2-0.3-0.0
Time to tail flick, test, after self-admin0.10.10.1-0.30.20.40.4-0.20.4-0.1
Delta time to tail flick, vehicle, before/after SA0.80.81.3-0.91.00.70.7-1.10.7-1.1
Delta time to tail flick, test, before/after SA0.30.30.4-0.60.60.60.6-0.30.6-0.2
Tibia length6.618.721.64.7-4.3-4.4-4.34.1-4.34.1
Ambulatory time before self-admin0.10.10.1-0.30.20.30.3-0.30.3-0.3
Ambulatory time after self-admin0.20.20.5-0.30.20.10.2-0.70.1-0.7
Bone: tissue strength3.23.23.51.8-1.8-1.7-1.71.7-1.71.9
Total heroin consumption1.31.51.51.2-1.2-1.2-1.21.2-1.21.2
Bone: trabecular number0.81.22.2-1.11.11.01.0-1.21.0-1.5
Bone: trabecular spacing1.72.33.11.5-1.6-1.4-1.41.5-1.41.8
Bone: trabecular thickness0.00.00.00.2-0.1-0.2-0.10.1-0.1-0.1
Bone: trabecular tissue density0.20.30.40.6-0.5-0.6-0.60.5-0.60.4
Water consumed over 24 hours0.00.00.0-0.10.10.10.1-0.10.10.1
Number of responses in last shaping day0.80.91.0-1.00.90.90.9-0.90.9-0.9