Hub : Genes

Nf2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL mRNA stability Nf2 0.14 0.11 7.6e-03 0.03 0.08 0.01 0.04 7.2e-02 6.4e-03 1.6e-01 3.6e-02
2 NAcc intron excision ratio chr14_79629701_79643226 0.04 0.03 8.1e-04 0.01 0.02 0.01 0.02 3.8e-02 6.8e-04 1.9e-02 3.2e-03
3 BLA intron excision ratio chr14_79629701_79643226 0.08 0.06 3.5e-03 0.02 0.04 0.02 0.02 4.1e-02 4.4e-03 2.5e-02 4.3e-02
4 PL mRNA stability Nf2 0.18 0.1 3.3e-16 0.14 0.14 0.13 0.14 3.3e-15 2.5e-15 1.5e-14 6.9e-15
5 BLA gene expression Nf2 0.1 0.07 8.0e-04 0.06 0.04 0.02 0.05 4.6e-04 4.4e-03 2.0e-02 1.8e-03
6 BLA isoform ratio NM_013193.1 0.09 0.07 1.8e-03 0.05 0.04 0.03 0.03 1.6e-03 2.1e-03 1.3e-02 9.4e-03
7 BLA mRNA stability Nf2 0.26 0.14 2.9e-09 0.16 0.16 0.14 0.16 4.7e-09 1.1e-08 3.7e-08 7.6e-09
8 LHb mRNA stability Nf2 0.66 0.16 1.5e-12 0.41 0.4 0.38 0.4 7.4e-11 1.5e-10 6.6e-10 1.9e-10
9 Adipose mRNA stability Nf2 0.48 0.14 0.0e+00 0.23 0.22 0.22 0.23 2.3e-25 1.7e-23 1.8e-24 4.5e-25
10 LHb gene expression Nf2 0.58 0.17 1.1e-10 0.38 0.36 0.36 0.36 6.6e-10 2.1e-09 1.5e-09 1.5e-09
11 PL gene expression Nf2 0.09 0.06 1.3e-07 0.07 0.07 0.06 0.06 5.3e-08 7.1e-08 1.6e-07 1.1e-07
12 pVTA mRNA stability Nf2 0.28 0.25 4.5e-06 0.15 0.13 0.13 0.14 6.9e-07 2.4e-06 2.1e-06 1.3e-06
13 OFC gene expression Nf2 0.29 0.17 5.2e-04 0.1 0.15 0.19 0.2 1.9e-03 2.4e-04 2.6e-05 2.1e-05
14 OFC mRNA stability Nf2 0.47 0.18 4.9e-08 0.31 0.29 0.28 0.29 4.7e-08 1.4e-07 2.4e-07 1.3e-07
15 NAcc isoform ratio XM_006251188.4 0.05 0.04 8.4e-05 0.04 0.03 0.03 0.04 5.3e-05 9.7e-05 1.3e-04 5.7e-05
16 NAcc gene expression Nf2 0.07 0.05 6.5e-06 0.04 0.03 0.04 0.04 7.8e-06 6.5e-05 4.3e-05 5.2e-05
17 BLA isoform ratio XM_006251188.4 0.12 0.08 1.6e-04 0.05 0.07 0.04 0.06 7.2e-04 1.6e-04 1.9e-03 4.9e-04
18 Liver isoform ratio XM_006251188.4 0.07 0.05 5.8e-05 0.02 0.03 0.03 0.02 5.9e-03 1.9e-04 7.4e-04 1.1e-03
19 Adipose isoform ratio XM_039091641.1 0.07 0.05 1.4e-05 0.03 0.04 0.03 0.03 1.1e-04 3.8e-05 1.3e-04 1.4e-04
20 Adipose isoform ratio XM_006251191.4 0.04 0.03 4.1e-04 0.01 0.02 0.02 0.01 1.1e-02 2.7e-03 2.9e-03 7.9e-03
21 Adipose isoform ratio XM_006251188.4 0.14 0.08 2.7e-10 0.07 0.08 0.07 0.07 4.0e-08 4.9e-09 1.6e-08 1.6e-08
22 Adipose intron excision ratio chr14_79641736_79643226 0.04 0.03 9.4e-04 0.01 0.02 0.01 0.01 5.7e-02 6.3e-03 2.4e-02 2.9e-02
23 Adipose intron excision ratio chr14_79629701_79643226 0.1 0.07 1.4e-07 0.05 0.05 0.03 0.04 4.1e-06 2.5e-06 1.0e-04 1.4e-05
24 pVTA gene expression Nf2 0.22 0.19 3.6e-05 0.1 0.1 0.1 0.1 5.4e-05 3.3e-05 3.8e-05 5.2e-05
25 Liver isoform ratio XM_039091641.1 0.04 0.03 7.6e-04 0 0.01 0.01 0.01 8.1e-02 2.9e-02 1.9e-02 1.9e-02
26 PL isoform ratio XM_006251188.4 0.03 0.03 3.3e-03 0.02 0.02 0.01 0.01 2.4e-03 6.2e-03 4.4e-02 8.0e-03
27 Brain isoform ratio XM_006251188.4 0.17 0.09 2.3e-13 0.17 0.15 0.16 0.17 2.9e-15 3.4e-14 1.0e-14 2.9e-15
28 Brain isoform ratio XM_039091641.1 0.07 0.05 2.1e-05 0.04 0.03 0.06 0.06 2.3e-04 5.5e-04 4.8e-06 4.7e-06
29 Brain mRNA stability Nf2 0.38 0.14 0.0e+00 0.36 0.33 0.35 0.35 1.4e-34 1.5e-31 1.2e-33 5.5e-34
30 PL intron excision ratio chr14_79629701_79643226 0.05 0.04 1.5e-04 0.03 0.03 0.02 0.03 1.5e-04 4.6e-04 9.4e-04 3.5e-04
31 Brain gene expression Nf2 0.22 0.11 5.6e-17 0.2 0.18 0.18 0.19 6.0e-18 8.4e-17 9.7e-17 3.4e-17
32 Brain intron excision ratio chr14_79629701_79643226 0.15 0.09 1.7e-11 0.14 0.12 0.14 0.14 2.6e-13 1.8e-11 8.3e-13 8.0e-13
33 NAcc mRNA stability Nf2 0.31 0.15 0.0e+00 0.23 0.23 0.23 0.23 7.3e-27 1.5e-26 1.1e-26 1.0e-26
34 Adipose alternative polyA NM_013193.1 0.05 0.04 8.4e-04 0.02 0.01 0.01 0.02 8.8e-04 9.3e-03 7.0e-03 3.6e-03
35 Brain intron excision ratio chr14_79641736_79643226 0.06 0.04 1.1e-04 0.06 0.04 0.05 0.06 3.3e-06 6.3e-05 1.2e-05 5.7e-06
36 Adipose alternative polyA XM_006251191.4 0.1 0.06 1.0e-08 0.06 0.06 0.06 0.06 3.4e-07 7.7e-07 8.1e-07 8.0e-07
37 Brain isoform ratio NM_013193.1 0.03 0.03 7.0e-03 0.02 0.01 0 0.01 6.0e-03 1.6e-02 1.9e-01 3.2e-02
38 Liver mRNA stability Nf2 0.04 0.03 1.3e-03 0.01 0.01 0 0.01 9.2e-03 1.7e-02 9.8e-02 6.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38
Bone: apparent density0.71.22.00.91.11.11.1-1.41.4-1.4-1.4-1.4-1.4-1.4-1.41.4-1.4-1.4-1.41.11.0-1.1-0.91.0-1.01.01.00.7-0.90.8-0.8-0.7-1.2-0.6-0.6-0.6-0.70.70.80.8-0.8
Area under the delay curve0.20.22.9-1.7-1.3-1.2-0.60.2-0.20.20.20.20.20.20.2-0.20.10.20.2-0.30.60.2-0.60.5-0.40.4-0.10.70.2-0.10.10.10.10.10.10.10.1-0.1-0.2-0.20.2
BMI with tail0.00.00.1-0.0-0.1-0.0-0.10.2-0.20.20.40.40.40.40.4-0.40.30.30.2-0.1-0.20.10.1-0.20.1-0.2-0.1-0.10.1-0.10.10.10.30.00.00.00.1-0.1-0.0-0.00.0
BMI without tail0.71.51.70.81.01.01.2-1.31.3-1.3-1.3-1.3-1.3-1.3-1.31.3-1.3-1.2-1.31.21.2-1.3-1.21.2-1.21.31.21.0-1.11.3-1.3-1.3-1.1-1.2-1.2-1.2-1.21.21.21.2-1.2
Body weight0.10.52.3-1.5-1.0-0.9-0.1-0.60.6-0.6-0.4-0.4-0.4-0.4-0.40.4-0.5-0.5-0.50.31.3-0.5-1.31.2-1.11.10.51.3-0.20.5-0.5-0.60.1-0.5-0.5-0.5-0.50.50.30.3-0.3
Weight adjusted by age0.91.12.2-0.20.20.30.7-1.01.0-1.0-1.0-1.0-1.0-1.0-1.01.0-1.0-1.0-1.00.91.4-1.0-1.41.3-1.31.31.11.5-1.01.0-1.0-1.0-1.0-1.1-1.1-1.1-1.11.11.11.1-1.1
Bone surface0.10.20.3-0.2-0.00.00.2-0.50.5-0.5-0.6-0.6-0.6-0.6-0.60.6-0.5-0.5-0.50.30.5-0.4-0.50.5-0.50.50.40.4-0.3-0.10.10.1-0.50.20.20.20.2-0.20.20.2-0.2
Bone volume0.20.40.60.00.20.30.5-0.80.8-0.8-0.8-0.8-0.8-0.8-0.80.8-0.7-0.8-0.70.60.8-0.6-0.80.7-0.70.70.70.6-0.60.2-0.2-0.2-0.7-0.2-0.2-0.2-0.20.20.40.4-0.4
Breakpoint value in progressive ratio session0.20.21.5-1.2-1.0-0.9-0.50.3-0.30.30.50.50.50.50.5-0.50.30.30.3-0.30.30.2-0.30.2-0.20.1-0.10.40.3-0.20.20.20.10.20.20.20.2-0.2-0.2-0.20.2
Number of licking bursts0.40.51.4-1.2-0.7-0.6-0.0-0.80.8-0.8-0.8-0.8-0.8-0.8-0.80.8-0.7-0.7-0.70.31.2-0.5-1.11.1-1.01.00.51.1-0.20.4-0.4-0.3-0.1-0.3-0.3-0.3-0.30.30.30.3-0.3
Context. condit. distance diff. score0.20.33.31.81.41.30.70.0-0.00.00.10.10.10.10.1-0.10.00.00.00.3-0.7-0.10.6-0.60.5-0.40.1-0.8-0.30.2-0.2-0.2-0.3-0.2-0.2-0.2-0.10.10.20.2-0.2
Locomotion velocity, session 13.53.84.7-1.2-1.6-1.7-2.02.1-2.12.11.91.91.91.91.9-1.92.02.02.0-2.1-2.02.12.1-2.12.1-2.1-2.2-2.02.1-1.81.81.82.11.81.81.81.8-1.8-2.0-2.02.0
Locomotion distance, session 10.60.81.51.21.21.21.1-0.70.7-0.7-0.8-0.8-0.8-0.8-0.80.8-0.7-0.7-0.71.00.5-0.9-0.60.6-0.70.70.90.7-1.00.9-0.9-0.9-1.1-1.0-1.0-1.0-1.11.11.11.1-1.1
Locomotion velocity, session 23.54.14.8-1.1-1.5-1.5-1.92.2-2.22.22.12.12.12.12.1-2.12.22.22.2-2.0-2.12.12.1-2.12.1-2.1-2.0-1.91.8-2.12.12.11.82.12.12.12.0-2.0-1.8-1.81.8
Locomotion distance, session 20.50.71.90.90.40.4-0.20.9-0.90.90.80.80.80.80.8-0.80.90.90.9-0.6-1.40.71.3-1.31.2-1.2-0.7-1.20.4-0.90.90.80.30.90.90.90.6-0.6-0.4-0.40.4
Locomotion velocity, session 30.50.53.51.91.61.61.1-0.50.5-0.5-0.6-0.6-0.6-0.6-0.60.6-0.5-0.5-0.50.9-0.0-0.7-0.10.1-0.20.20.7-0.1-0.90.7-0.7-0.7-0.9-0.6-0.6-0.6-0.40.40.70.7-0.7
Locomotion distance, session 30.10.10.20.1-0.00.10.00.4-0.40.40.40.40.40.40.4-0.40.40.40.40.0-0.20.1-0.0-0.10.0-0.10.20.2-0.3-0.20.20.2-0.40.30.30.30.4-0.40.10.1-0.1
Stereotopy head waving bouts, day 30.10.21.21.10.90.90.6-0.00.0-0.0-0.2-0.2-0.2-0.2-0.20.2-0.1-0.1-0.00.5-0.1-0.3-0.0-0.0-0.10.00.5-0.0-0.60.4-0.4-0.4-0.6-0.4-0.4-0.4-0.30.30.40.4-0.4
Stereotopy head waving duration, day 30.10.11.21.10.80.70.30.2-0.20.20.10.10.10.10.1-0.10.20.20.20.1-0.60.10.6-0.50.5-0.4-0.1-0.6-0.00.1-0.1-0.1-0.1-0.1-0.1-0.10.0-0.00.00.0-0.0
Locomotion velocity, session 70.20.20.3-0.5-0.5-0.5-0.40.5-0.50.50.50.50.50.50.5-0.50.50.50.5-0.4-0.30.40.2-0.30.3-0.3-0.3-0.00.2-0.40.40.50.30.50.50.50.5-0.5-0.2-0.20.2
Locomotion distance, session 70.30.40.70.2-0.0-0.1-0.40.6-0.60.60.60.60.60.60.6-0.60.60.60.6-0.5-0.80.60.8-0.80.8-0.8-0.6-0.80.5-0.60.60.60.60.60.60.60.7-0.7-0.4-0.40.4
Stereotopy head waving bouts, day 70.00.00.30.50.50.40.3-0.20.2-0.2-0.2-0.2-0.2-0.2-0.20.2-0.2-0.2-0.20.2-0.0-0.20.1-0.00.00.00.1-0.2-0.10.2-0.2-0.3-0.1-0.3-0.3-0.3-0.10.10.00.0-0.0
Stereotopy head waving duration, day 70.40.50.70.50.60.60.7-0.70.7-0.7-0.6-0.6-0.6-0.6-0.60.6-0.7-0.7-0.70.70.7-0.7-0.70.7-0.70.70.80.6-0.80.8-0.8-0.8-0.8-0.8-0.8-0.8-0.60.60.60.6-0.6
Locomotion velocity, session 81.72.03.70.4-0.2-0.3-0.91.6-1.61.61.61.61.61.61.6-1.61.61.61.6-1.2-1.91.41.8-1.81.7-1.7-1.2-1.71.0-1.31.31.30.91.41.41.41.4-1.4-1.1-1.11.1
Locomotion distance, session 80.50.77.42.72.01.80.80.3-0.30.30.30.30.30.30.3-0.30.30.30.30.2-1.40.11.3-1.21.0-1.0-0.2-1.4-0.2-0.00.0-0.0-0.20.00.00.0-0.10.10.20.2-0.2
Degree of sensitization distance0.40.41.80.60.30.1-0.40.4-0.40.40.40.40.40.40.4-0.40.40.40.4-0.6-1.10.61.2-1.01.0-0.9-0.9-1.30.9-0.50.50.51.00.40.40.40.4-0.4-0.7-0.70.7
Degree of sensitization stereotypy0.20.20.5-0.10.10.00.2-0.60.6-0.6-0.6-0.6-0.6-0.6-0.60.6-0.7-0.7-0.60.30.6-0.4-0.50.5-0.50.50.20.3-0.10.4-0.4-0.5-0.1-0.4-0.4-0.4-0.30.30.10.1-0.1
Conditioned locomotion1.31.52.81.71.71.71.5-1.11.1-1.1-1.1-1.1-1.1-1.1-1.11.1-1.2-1.2-1.21.40.8-1.3-0.90.9-1.01.01.30.8-1.41.3-1.3-1.3-1.2-1.4-1.4-1.4-1.41.41.21.2-1.2
Cocaine response after cond. corrected0.20.21.2-1.1-0.8-0.7-0.2-0.30.3-0.3-0.4-0.4-0.4-0.4-0.40.4-0.4-0.4-0.40.00.8-0.2-0.70.7-0.60.60.20.80.00.2-0.2-0.30.1-0.2-0.2-0.2-0.20.20.20.2-0.2
Cocaine response after cond. not corrected0.60.62.1-0.9-0.5-0.40.2-0.70.7-0.7-0.7-0.7-0.7-0.7-0.70.7-0.7-0.7-0.70.51.3-0.7-1.21.2-1.11.10.71.4-0.50.8-0.8-0.8-0.4-0.8-0.8-0.8-0.80.80.80.8-0.8
Cocaine response before conditioning0.20.30.70.70.70.70.7-0.30.3-0.3-0.3-0.3-0.3-0.3-0.30.3-0.2-0.2-0.20.60.3-0.5-0.40.3-0.40.40.60.4-0.60.6-0.6-0.6-0.8-0.6-0.6-0.6-0.60.60.70.7-0.7
Saline control response0.50.61.30.50.10.1-0.40.8-0.80.80.80.80.80.80.8-0.80.80.80.8-0.6-1.10.71.0-1.11.0-1.0-0.6-1.00.4-0.80.80.80.70.80.80.80.8-0.8-0.5-0.50.5
Bone: connectivity density0.50.81.41.01.01.01.0-1.11.1-1.1-1.2-1.2-1.2-1.2-1.21.2-1.1-1.2-1.10.90.7-0.9-0.60.7-0.70.70.80.5-0.80.5-0.5-0.5-0.9-0.4-0.4-0.4-0.50.50.70.7-0.7
Bone: cortical apparent density0.10.10.5-0.7-0.4-0.4-0.1-0.20.2-0.2-0.2-0.2-0.2-0.2-0.20.2-0.2-0.2-0.20.10.6-0.2-0.60.5-0.50.50.20.6-0.10.3-0.3-0.3-0.1-0.3-0.3-0.3-0.20.20.20.2-0.2
Bone: cortical area0.20.32.4-1.5-1.1-1.0-0.3-0.20.2-0.2-0.2-0.2-0.2-0.2-0.20.2-0.2-0.2-0.20.11.0-0.2-1.00.9-0.80.80.41.2-0.20.0-0.0-0.1-0.3-0.1-0.1-0.1-0.20.20.20.2-0.2
Bone: cortical porosity0.60.71.00.20.50.50.7-1.01.0-1.0-1.0-1.0-1.0-1.0-1.01.0-1.0-1.0-1.00.80.9-0.8-0.90.9-0.90.90.70.9-0.70.8-0.8-0.8-0.7-0.7-0.7-0.7-0.70.70.80.8-0.8
Bone: cortical porosity0.40.40.60.60.60.60.6-0.80.8-0.8-0.8-0.8-0.8-0.8-0.80.8-0.8-0.8-0.80.60.5-0.6-0.40.5-0.50.50.50.4-0.40.6-0.6-0.6-0.5-0.5-0.5-0.5-0.50.50.50.5-0.5
Bone: cortical thickness0.71.23.5-0.7-0.2-0.00.6-1.01.0-1.0-1.0-1.0-1.0-1.0-1.01.0-1.0-1.0-1.01.01.7-1.1-1.71.6-1.61.51.31.9-1.10.9-0.9-0.9-1.2-0.9-0.9-0.9-1.01.01.01.0-1.0
Bone: cortical thickness2.12.42.91.51.61.71.7-1.71.7-1.7-1.7-1.7-1.7-1.7-1.71.7-1.7-1.7-1.71.61.3-1.6-1.31.4-1.41.51.61.2-1.51.5-1.5-1.4-1.5-1.4-1.4-1.4-1.51.51.51.5-1.5
Bone: cortical tissue density0.10.10.6-0.8-0.5-0.5-0.2-0.10.1-0.1-0.1-0.1-0.1-0.1-0.10.1-0.1-0.1-0.10.00.5-0.1-0.50.4-0.40.40.10.5-0.00.2-0.2-0.2-0.0-0.2-0.2-0.2-0.10.10.10.1-0.1
Condit. Reinf. active minus inactive responses2.02.32.8-1.4-1.6-1.6-1.71.5-1.51.51.41.41.41.41.4-1.41.41.41.4-1.6-1.31.61.4-1.41.4-1.4-1.6-1.31.6-1.61.61.61.61.61.61.61.5-1.5-1.6-1.61.6
Condit. Reinf. active-inactive response ratio5.96.47.7-1.5-1.9-2.1-2.52.5-2.52.52.52.52.52.52.5-2.52.52.52.5-2.7-2.72.72.7-2.72.7-2.7-2.8-2.72.7-2.62.62.62.62.52.52.52.5-2.5-2.6-2.62.6
Condit. Reinf. active responses0.70.91.2-0.9-1.0-1.0-1.01.0-1.01.00.90.90.90.90.9-0.90.90.90.9-1.0-0.91.00.9-0.90.9-0.9-1.0-0.90.9-1.01.01.11.01.11.11.10.9-0.9-1.1-1.11.1
Condit. Reinf. inactive responses0.81.01.50.40.60.71.0-0.90.9-0.9-1.0-1.0-1.0-1.0-1.01.0-0.9-1.0-0.91.11.1-1.1-1.21.1-1.21.11.21.2-1.20.9-0.9-0.9-1.1-0.8-0.8-0.8-0.90.91.01.0-1.0
Incentive salience index mean1.01.31.9-1.3-1.4-1.4-1.31.2-1.21.21.11.11.11.11.1-1.11.21.11.2-1.2-0.81.20.8-0.90.9-1.0-1.1-0.71.1-1.21.21.21.01.31.31.31.0-1.0-1.1-1.11.1
Condit. Reinf. lever presses0.00.00.2-0.2-0.2-0.1-0.00.2-0.20.20.20.20.20.20.2-0.20.20.20.20.00.1-0.0-0.20.1-0.10.10.20.4-0.3-0.10.10.1-0.30.20.20.2-0.10.10.30.3-0.3
Condit. Reinf. active minus inactive responses0.00.10.40.60.50.40.1-0.20.2-0.2-0.1-0.1-0.1-0.1-0.10.1-0.1-0.1-0.1-0.0-0.30.00.4-0.30.3-0.2-0.2-0.40.20.1-0.1-0.00.30.10.10.10.1-0.10.10.1-0.1
Condit. Reinf. active-inactive response ratio0.00.00.30.00.0-0.1-0.2-0.10.1-0.1-0.0-0.0-0.0-0.0-0.00.0-0.0-0.0-0.0-0.2-0.20.20.3-0.20.3-0.2-0.4-0.30.4-0.10.10.20.50.20.20.20.2-0.2-0.2-0.20.2
Condit. Reinf. active responses0.10.10.60.60.30.2-0.10.3-0.30.30.30.30.30.30.3-0.30.30.30.3-0.3-0.70.40.8-0.70.7-0.6-0.5-0.70.4-0.10.10.10.50.20.20.20.2-0.2-0.1-0.10.1
Condit. Reinf. inactive responses0.20.30.80.50.20.1-0.30.6-0.60.60.50.50.50.50.5-0.50.60.60.6-0.5-0.90.50.9-0.80.8-0.8-0.6-0.80.5-0.30.30.30.50.30.30.30.3-0.3-0.3-0.30.3
Condit. Reinf. lever presses0.10.10.80.90.70.70.4-0.20.2-0.2-0.3-0.3-0.3-0.3-0.30.3-0.2-0.2-0.20.3-0.1-0.20.1-0.10.00.00.2-0.0-0.30.3-0.3-0.3-0.3-0.3-0.3-0.3-0.30.30.40.4-0.4
Condit. Reinf. lever reinforcers received0.10.10.40.60.40.3-0.10.2-0.20.20.20.20.20.20.2-0.20.30.30.3-0.2-0.60.30.7-0.60.6-0.5-0.4-0.50.3-0.10.10.10.40.10.10.10.1-0.1-0.0-0.00.0
Conditioned reinforcement - actives0.60.61.1-0.4-0.6-0.5-0.60.8-0.80.81.01.01.01.01.0-1.01.11.10.8-0.6-0.70.70.5-0.70.6-0.7-0.5-0.50.6-0.80.80.80.50.80.80.80.8-0.8-0.7-0.70.7
Conditioned reinforcement - inactives0.10.20.5-0.5-0.5-0.5-0.40.3-0.30.30.50.50.50.50.5-0.50.40.40.3-0.4-0.30.40.3-0.30.3-0.3-0.4-0.20.4-0.30.30.30.70.30.30.30.3-0.3-0.4-0.40.4
Conditioned locomotion0.10.10.2-0.10.00.10.2-0.30.3-0.3-0.0-0.0-0.0-0.0-0.00.00.10.1-0.30.30.3-0.3-0.40.3-0.40.30.40.5-0.30.2-0.2-0.2-0.3-0.2-0.2-0.2-0.30.30.30.3-0.3
Patch foraging indifference point 0 sec0.10.21.5-1.2-0.8-0.7-0.2-0.20.2-0.2-0.2-0.2-0.2-0.2-0.20.2-0.3-0.3-0.30.10.9-0.2-0.80.8-0.70.70.30.9-0.10.2-0.2-0.20.2-0.1-0.1-0.1-0.10.10.10.1-0.1
Patch foraging indifference point AUC0.30.30.7-0.5-0.6-0.6-0.60.8-0.80.80.60.60.60.60.6-0.60.70.70.7-0.6-0.50.60.4-0.50.5-0.5-0.5-0.20.3-0.50.50.50.70.40.40.40.4-0.4-0.3-0.30.3
Delay disc. indifference point, 0s delay0.10.20.6-0.8-0.5-0.4-0.0-0.30.3-0.3-0.3-0.3-0.3-0.3-0.30.3-0.3-0.3-0.30.20.7-0.3-0.70.7-0.60.60.30.7-0.20.4-0.4-0.4-0.4-0.4-0.4-0.4-0.40.40.20.2-0.2
Delay disc. indifference point, 16s delay1.71.74.5-2.1-2.0-2.0-1.61.3-1.31.31.31.31.31.31.3-1.31.21.31.3-1.4-0.61.30.7-0.70.8-0.9-1.2-0.51.3-1.31.31.31.11.31.31.31.3-1.3-1.3-1.31.3
Delay disc. indifference point, 2s delay1.61.83.3-0.20.30.41.0-1.31.3-1.3-1.3-1.3-1.3-1.3-1.31.3-1.2-1.3-1.31.21.8-1.3-1.81.7-1.71.71.41.8-1.31.4-1.4-1.4-1.4-1.4-1.4-1.4-1.41.41.31.3-1.3
Delay disc. indifference point, 24s delay0.80.71.8-1.3-1.3-1.3-1.10.9-0.90.90.90.90.90.90.9-0.90.90.90.9-0.9-0.50.90.5-0.50.6-0.6-0.8-0.40.9-0.80.80.80.70.80.80.80.8-0.8-0.9-0.90.9
Delay disc. indifference point, 4s delay0.60.71.9-1.1-0.6-0.50.2-0.70.7-0.7-0.7-0.7-0.7-0.7-0.70.7-0.6-0.7-0.70.51.4-0.7-1.31.3-1.21.20.81.4-0.60.8-0.8-0.8-0.7-0.8-0.8-0.8-0.80.80.60.6-0.6
Delay disc. indifference point, 8s delay0.20.21.4-1.2-1.0-1.0-0.70.4-0.40.40.40.40.40.40.4-0.40.40.40.4-0.5-0.00.50.1-0.10.1-0.2-0.40.00.5-0.40.40.40.40.40.40.40.4-0.4-0.5-0.50.5
Indifference point function ln k0.60.91.50.70.80.91.0-1.01.0-1.0-1.0-1.0-1.0-1.0-1.01.0-1.0-1.0-1.01.00.9-1.0-0.90.9-1.00.91.00.8-0.90.9-0.9-0.9-1.2-0.9-0.9-0.9-0.90.90.80.8-0.8
Indifference point function log k0.60.91.50.70.80.91.0-1.01.0-1.0-1.0-1.0-1.0-1.0-1.01.0-1.0-1.0-1.01.00.9-1.0-0.90.9-1.00.91.00.8-0.90.9-0.9-0.9-1.2-0.9-0.9-0.9-0.90.90.80.8-0.8
Patch foraging total patch changes 0 sec0.10.21.8-1.4-1.0-0.9-0.40.0-0.00.00.00.00.00.00.0-0.00.00.00.0-0.20.60.0-0.60.5-0.50.40.10.70.1-0.00.00.00.40.20.20.20.2-0.2-0.1-0.10.1
Patch foraging total patch changes 12 sec0.10.11.0-1.0-0.8-0.7-0.40.3-0.30.30.20.20.20.20.2-0.20.20.20.2-0.20.30.1-0.30.3-0.20.2-0.00.6-0.00.0-0.0-0.00.6-0.1-0.1-0.1-0.10.10.00.0-0.0
Patch foraging total patch changes 18 sec1.92.44.4-2.1-2.1-2.1-1.91.6-1.61.61.41.41.41.41.4-1.41.51.51.5-1.7-1.01.61.1-1.11.2-1.2-1.6-0.81.7-1.51.51.62.01.61.61.61.6-1.6-1.5-1.51.5
Patch foraging total patch changes 24 sec0.70.91.70.2-0.1-0.3-0.71.0-1.01.00.70.70.70.70.7-0.70.80.80.8-0.9-1.31.01.3-1.31.2-1.2-1.1-1.31.0-0.90.90.91.31.11.11.11.1-1.1-0.9-0.90.9
Patch foraging total patch changes 6 sec0.20.32.0-1.4-1.2-1.1-0.80.6-0.60.60.50.50.50.50.5-0.50.50.50.5-0.50.10.5-0.10.00.0-0.1-0.30.30.3-0.50.50.50.60.60.60.60.6-0.6-0.4-0.40.4
Patch foraging time to switch 0 sec0.10.10.40.60.60.50.4-0.50.5-0.5-0.4-0.4-0.4-0.4-0.40.4-0.4-0.4-0.40.30.1-0.3-0.10.1-0.10.20.2-0.0-0.20.4-0.4-0.3-0.2-0.4-0.4-0.4-0.40.40.30.3-0.3
Patch foraging water rate 0 sec0.50.72.5-1.6-1.5-1.4-1.10.8-0.80.80.90.90.90.90.9-0.90.90.90.9-0.9-0.30.80.2-0.30.4-0.4-0.60.00.7-0.80.80.90.90.90.90.90.9-0.9-0.6-0.60.6
Patch foraging water rate 12 sec0.00.00.2-0.00.00.00.0-0.10.1-0.1-0.1-0.1-0.1-0.1-0.10.1-0.1-0.1-0.10.00.0-0.0-0.10.0-0.00.00.1-0.00.0-0.20.20.3-0.20.40.40.40.4-0.4-0.0-0.00.0
Patch foraging water rate 18 sec2.94.04.91.21.61.61.9-2.22.2-2.2-2.1-2.1-2.1-2.1-2.12.1-2.2-2.2-2.22.02.1-2.1-2.02.1-2.02.12.01.8-1.82.1-2.1-2.1-1.7-1.9-1.9-1.9-1.91.91.91.9-1.9
Patch foraging water rate 24 sec0.70.91.2-0.7-0.8-0.9-1.00.9-0.90.91.01.01.01.01.0-1.00.90.90.9-1.0-0.91.01.0-1.01.0-1.0-1.0-1.01.1-1.01.01.00.91.01.01.01.0-1.0-1.0-1.01.0
Patch foraging water rate 6 sec0.20.20.5-0.2-0.00.00.3-0.50.5-0.5-0.5-0.5-0.5-0.5-0.50.5-0.5-0.5-0.50.40.7-0.5-0.70.7-0.70.60.50.6-0.40.4-0.4-0.3-0.4-0.4-0.4-0.4-0.40.40.40.4-0.4
Seeking ratio, delayed vs. immediate footshock0.00.00.10.0-0.0-0.1-0.20.2-0.20.20.10.10.10.10.1-0.10.30.30.2-0.2-0.30.20.3-0.30.3-0.3-0.2-0.30.2-0.20.20.20.10.20.20.20.2-0.2-0.2-0.20.2
Distance traveled before self-admin1.21.32.10.10.50.60.9-1.21.2-1.2-1.2-1.2-1.2-1.2-1.21.2-1.1-1.1-1.11.11.4-1.2-1.41.4-1.41.41.21.5-1.21.1-1.1-1.1-1.3-1.0-1.0-1.0-1.01.01.11.1-1.1
Distance traveled after self-admin0.91.11.60.30.50.60.9-1.01.0-1.0-1.0-1.0-1.0-1.0-1.01.0-1.0-1.0-1.01.01.2-1.1-1.31.2-1.21.21.21.2-1.11.1-1.1-1.1-0.9-1.0-1.0-1.0-1.01.00.90.9-0.9
Extensor digitorum longus weight0.20.96.2-2.5-1.7-1.5-0.4-0.60.6-0.6-0.6-0.6-0.6-0.6-0.60.6-0.6-0.6-0.60.21.8-0.5-1.71.6-1.41.30.61.7-0.20.3-0.3-0.3-0.3-0.3-0.3-0.3-0.30.30.00.0-0.0
Bone: elastic displacement1.31.51.91.31.41.41.4-1.41.4-1.4-1.3-1.3-1.3-1.3-1.31.3-1.3-1.3-1.31.31.0-1.3-1.01.1-1.11.11.20.7-1.21.3-1.3-1.3-1.0-1.2-1.2-1.2-1.11.11.11.1-1.1
Bone: elastic work1.92.53.00.71.11.21.5-1.71.7-1.7-1.7-1.7-1.7-1.7-1.71.7-1.7-1.7-1.71.61.7-1.6-1.71.7-1.71.71.61.4-1.41.6-1.6-1.6-1.4-1.6-1.6-1.6-1.51.51.31.3-1.3
Bone: endosteal estimation0.00.00.2-0.4-0.3-0.3-0.1-0.10.1-0.1-0.1-0.1-0.1-0.1-0.10.1-0.1-0.1-0.1-0.00.3-0.1-0.20.2-0.20.20.10.10.00.1-0.1-0.1-0.0-0.1-0.1-0.10.0-0.0-0.1-0.10.1
Bone: endosteal perimeter0.10.11.4-1.2-1.0-0.9-0.60.2-0.20.20.20.20.20.20.2-0.20.20.20.2-0.40.20.3-0.20.2-0.10.1-0.20.20.3-0.30.30.20.30.20.20.20.0-0.0-0.3-0.30.3
Epididymis fat weight0.71.72.61.51.61.61.6-1.31.3-1.3-1.3-1.3-1.3-1.3-1.31.3-1.2-1.3-1.21.51.0-1.4-1.11.1-1.21.21.51.1-1.61.2-1.2-1.2-1.3-1.3-1.3-1.3-1.31.31.51.5-1.5
Delta time in closed arm before/after self-admin0.90.95.12.32.01.91.3-0.80.8-0.8-0.8-0.8-0.8-0.8-0.80.8-0.8-0.8-0.80.9-0.1-0.80.10.1-0.10.20.7-0.3-0.80.8-0.8-0.8-0.9-0.7-0.7-0.7-0.80.80.80.8-0.8
Delta time in open arm before/after self-admin1.41.48.2-2.9-2.5-2.3-1.61.1-1.11.11.01.01.01.01.0-1.01.11.11.1-1.20.11.0-0.1-0.10.2-0.3-0.80.40.9-1.11.11.10.91.11.11.11.1-1.1-1.0-1.01.0
Diff in mean of infusions in LGA sessions0.40.40.90.50.60.60.6-0.50.5-0.5-0.6-0.6-0.6-0.6-0.60.6-0.6-0.6-0.60.50.5-0.5-0.40.5-0.50.50.50.6-0.60.8-0.8-0.8-0.3-0.9-0.9-0.9-0.90.90.90.9-0.9
Delay discount exponential model param0.20.22.51.61.21.10.5-0.10.1-0.1-0.1-0.1-0.1-0.1-0.10.1-0.1-0.1-0.10.2-0.6-0.10.6-0.50.5-0.40.0-0.7-0.20.0-0.0-0.0-0.0-0.0-0.0-0.0-0.00.00.10.1-0.1
Extinction: sum of active levers before priming1.51.51.9-1.1-1.2-1.2-1.21.3-1.31.31.31.31.31.31.3-1.31.31.31.3-1.1-1.01.20.9-1.01.0-1.0-1.0-0.91.4-1.31.31.31.11.31.31.31.2-1.2-1.3-1.31.3
Active lever presses in extinction session 60.30.30.7-0.10.10.20.4-0.50.5-0.5-0.5-0.5-0.5-0.5-0.50.5-0.5-0.5-0.50.60.8-0.6-0.80.8-0.80.70.70.8-0.60.6-0.6-0.6-0.8-0.5-0.5-0.5-0.60.60.60.6-0.6
Bone: final force0.00.00.2-0.5-0.3-0.3-0.0-0.10.1-0.1-0.2-0.2-0.2-0.2-0.20.2-0.1-0.1-0.20.10.4-0.1-0.40.3-0.30.30.20.5-0.1-0.00.00.0-0.30.00.00.00.1-0.10.10.1-0.1
Bone: final moment0.10.20.5-0.5-0.3-0.20.1-0.40.4-0.4-0.4-0.4-0.4-0.4-0.40.4-0.4-0.4-0.40.30.7-0.3-0.60.6-0.60.60.40.7-0.30.2-0.2-0.2-0.4-0.2-0.2-0.2-0.10.10.30.3-0.3
Food consumed during 24 hour testing period2.12.64.1-2.0-2.0-2.0-1.81.7-1.71.71.71.71.71.71.7-1.71.71.71.7-1.7-1.11.61.1-1.21.2-1.3-1.4-1.01.5-1.71.71.61.21.61.61.61.6-1.6-1.6-1.61.6
Glucose20.931.550.4-7.0-7.1-7.1-6.65.6-5.65.65.65.65.65.65.6-5.65.65.65.6-6.1-3.95.84.1-4.24.5-4.6-5.6-3.65.7-5.65.65.65.95.65.65.65.7-5.7-5.8-5.85.8
Heart weight0.81.22.30.1-0.2-0.4-0.81.0-1.01.00.90.90.90.90.9-0.91.00.91.0-1.0-1.41.11.4-1.41.4-1.3-1.2-1.51.0-1.31.31.30.91.31.31.31.3-1.3-1.0-1.01.0
Delay discount hyperbolic model param0.20.22.31.51.11.00.40.0-0.00.00.00.00.00.00.0-0.00.00.00.00.1-0.70.00.7-0.70.6-0.5-0.1-0.8-0.1-0.10.10.10.10.10.10.10.1-0.10.00.0-0.0
Intermittent access intake day 1-15 change2.22.23.5-1.0-1.2-1.2-1.31.5-1.51.51.91.91.91.91.9-1.91.61.61.5-1.4-1.31.41.3-1.31.3-1.4-1.3-1.21.4-1.41.41.41.11.51.51.51.5-1.5-1.4-1.41.4
Intermittent access intake escalation1.71.73.2-0.7-0.9-0.9-1.11.3-1.31.31.81.81.81.81.8-1.81.41.41.3-1.1-1.21.21.1-1.21.2-1.2-1.1-1.01.1-1.21.21.20.91.21.21.21.2-1.2-1.2-1.21.2
Intermittent access intake escalation 20.60.61.3-0.4-0.5-0.6-0.70.6-0.60.61.21.21.21.21.2-1.10.80.80.6-0.7-0.70.70.7-0.70.7-0.7-0.7-0.60.7-0.60.60.70.50.70.70.70.7-0.7-0.7-0.70.7
Intermitt. access day 1 inactive lever presses0.20.20.80.70.40.3-0.10.2-0.20.2-0.2-0.2-0.2-0.2-0.20.20.10.20.2-0.3-0.70.40.8-0.70.7-0.6-0.6-0.90.5-0.30.30.30.60.30.30.30.3-0.3-0.3-0.30.3
Intermitt. access day 15 inactive lever presses2.93.14.0-1.6-1.8-1.8-1.91.9-1.91.91.51.51.51.51.5-1.51.71.71.9-1.9-1.61.91.6-1.71.7-1.7-1.9-1.52.0-1.81.81.91.91.91.91.91.9-1.9-1.9-1.91.9
Intermitt. access escalation Index0.50.51.3-0.5-0.6-0.6-0.70.7-0.70.70.60.60.60.60.6-0.60.60.60.7-0.7-0.70.70.7-0.70.7-0.7-0.8-0.70.9-0.70.70.61.10.70.70.70.7-0.7-0.7-0.70.7
Intermittent access day 1 total infusions0.20.30.50.20.30.30.4-0.60.6-0.6-0.7-0.7-0.7-0.7-0.70.7-0.3-0.3-0.60.50.5-0.5-0.50.5-0.50.50.50.6-0.60.5-0.5-0.5-0.5-0.5-0.5-0.5-0.50.50.50.5-0.5
Intermittent access day 15 total infusions0.30.30.9-0.7-0.8-0.7-0.60.6-0.60.60.70.70.70.70.7-0.70.90.90.6-0.5-0.40.60.3-0.40.4-0.4-0.4-0.20.4-0.60.60.60.40.60.60.60.6-0.6-0.5-0.50.5
Intermittent access terminal intake (last 3 days)0.30.30.7-0.7-0.7-0.7-0.60.5-0.50.50.60.60.60.60.6-0.60.80.80.5-0.5-0.40.50.3-0.40.4-0.4-0.4-0.20.4-0.60.60.60.30.60.60.60.6-0.6-0.5-0.50.5
Intermittent access total infusions0.00.00.1-0.3-0.3-0.2-0.0-0.00.0-0.00.00.00.00.00.0-0.00.30.3-0.00.00.2-0.0-0.20.2-0.20.10.20.3-0.1-0.00.00.0-0.20.00.00.0-0.00.00.00.0-0.0
Intermittent access day 1 locomotion0.20.20.60.80.70.70.5-0.50.5-0.5-0.3-0.3-0.3-0.3-0.30.3-0.2-0.2-0.50.40.1-0.4-0.10.2-0.20.20.30.1-0.40.5-0.5-0.5-0.4-0.5-0.5-0.5-0.50.50.40.4-0.4
Intermittent access day 15 total locomotion0.50.61.0-0.9-0.9-0.9-0.90.7-0.70.70.90.90.90.90.9-0.91.01.00.7-0.8-0.50.80.5-0.60.6-0.6-0.7-0.40.8-0.70.70.70.70.70.70.70.7-0.7-0.7-0.70.7
Intermittent access total locomotion0.20.20.5-0.7-0.7-0.6-0.50.3-0.30.30.60.60.60.60.6-0.60.70.70.3-0.4-0.20.40.1-0.20.2-0.2-0.30.00.4-0.40.40.40.30.40.40.40.4-0.4-0.4-0.40.4
Intermittent access standard deviation0.10.11.01.00.80.70.4-0.10.1-0.1-0.0-0.0-0.0-0.0-0.00.00.20.2-0.10.2-0.4-0.10.3-0.30.2-0.20.1-0.3-0.20.1-0.1-0.1-0.5-0.1-0.1-0.1-0.10.10.20.2-0.2
Left kidney weight0.61.82.50.91.11.11.2-1.51.5-1.5-1.6-1.6-1.6-1.6-1.61.6-1.5-1.5-1.51.31.3-1.3-1.21.3-1.21.31.11.0-1.11.3-1.3-1.4-1.1-1.4-1.4-1.4-1.41.41.11.1-1.1
Right kidney weight1.95.36.92.32.52.42.4-2.62.6-2.6-2.6-2.6-2.6-2.6-2.62.6-2.6-2.6-2.62.31.9-2.3-1.71.9-1.92.02.01.3-1.92.3-2.3-2.3-1.9-2.4-2.4-2.4-2.42.41.91.9-1.9
Cocaine induced anxiety0.91.12.9-1.7-1.6-1.5-1.11.0-1.01.01.41.41.41.41.4-1.41.11.11.0-0.8-0.20.80.1-0.30.3-0.4-0.50.00.9-1.01.01.00.51.01.01.00.9-0.9-0.9-0.90.9
Post-drug Anxiety1.01.11.6-1.2-1.3-1.2-1.11.1-1.11.11.11.11.11.11.1-1.11.01.01.1-1.0-0.71.00.6-0.70.7-0.8-0.9-0.61.1-1.11.11.10.81.11.11.11.1-1.1-1.1-1.11.1
Baseline Anxiety0.50.51.0-0.1-0.3-0.4-0.70.8-0.80.80.30.30.30.30.3-0.30.40.40.8-0.8-0.90.81.0-0.90.9-0.9-0.9-1.00.8-0.80.80.80.80.80.80.80.8-0.8-0.8-0.80.8
Tail length1.75.19.3-0.40.40.61.5-2.52.5-2.5-2.4-2.4-2.4-2.4-2.42.4-2.6-2.5-2.52.03.1-2.3-2.92.9-2.82.82.12.7-1.72.3-2.3-2.3-1.8-2.2-2.2-2.2-2.22.21.81.8-1.8
Length with tail0.41.44.3-1.7-1.0-0.80.2-1.21.2-1.2-1.2-1.2-1.2-1.2-1.21.2-1.3-1.2-1.20.72.1-1.0-1.91.9-1.71.70.91.9-0.51.0-1.0-1.1-0.4-1.0-1.0-1.0-1.01.00.50.5-0.5
Length without tail0.51.13.6-1.9-1.8-1.7-1.41.0-1.01.01.11.11.11.11.1-1.11.00.91.0-1.1-0.41.00.4-0.50.5-0.6-0.9-0.21.1-1.01.01.01.20.90.90.90.9-0.9-1.1-1.11.1
Times rat made contact with spout4.14.86.0-1.3-1.7-1.8-2.12.5-2.52.52.32.32.32.32.3-2.32.32.32.3-2.2-2.22.22.2-2.22.2-2.2-2.1-2.12.0-2.32.32.31.92.22.22.22.2-2.2-2.1-2.12.1
Lifetime Intake0.10.10.5-0.2-0.1-0.00.2-0.30.3-0.3-0.2-0.2-0.2-0.2-0.20.20.00.0-0.30.30.5-0.3-0.60.5-0.50.50.50.7-0.50.3-0.3-0.3-0.6-0.3-0.3-0.3-0.30.30.30.3-0.3
Liver weight, left3.75.97.42.42.62.52.5-2.72.7-2.7-2.7-2.7-2.7-2.7-2.72.7-2.7-2.7-2.72.42.0-2.4-1.82.0-2.02.12.11.5-2.02.7-2.7-2.6-1.8-2.5-2.5-2.5-2.52.52.22.2-2.2
Liver weight, right2.54.17.22.72.72.62.3-2.02.0-2.0-2.1-2.1-2.1-2.1-2.12.1-2.1-2.1-2.12.11.3-2.0-1.21.4-1.41.51.81.0-1.92.2-2.2-2.1-1.9-2.2-2.2-2.2-2.22.21.91.9-1.9
Locomotor activity0.71.12.3-1.5-1.5-1.5-1.31.0-1.01.01.11.11.11.11.1-1.11.11.11.1-1.2-0.61.10.7-0.70.8-0.8-1.1-0.61.2-0.80.80.81.50.80.80.80.8-0.8-1.1-1.11.1
Locomotor testing distance1.01.62.50.20.50.61.0-1.21.2-1.2-1.2-1.2-1.2-1.2-1.21.2-1.2-1.2-1.21.21.5-1.3-1.51.5-1.41.41.31.6-1.11.5-1.5-1.5-0.8-1.5-1.5-1.5-1.51.51.31.3-1.3
Locomotor testing rearing0.20.32.2-1.5-1.3-1.1-0.70.5-0.50.50.50.50.50.50.5-0.50.50.50.5-0.40.30.3-0.30.2-0.10.1-0.20.50.3-0.20.20.20.60.20.20.20.2-0.2-0.3-0.30.3
Locomotion in novel chamber1.01.35.52.32.12.01.5-1.11.1-1.1-1.1-1.1-1.1-1.1-1.11.1-1.1-1.1-1.11.20.3-1.1-0.30.4-0.50.51.00.0-1.21.1-1.1-1.1-1.2-1.0-1.0-1.0-1.01.01.01.0-1.0
Locomotion in novel chamber post-restriction1.61.94.90.80.20.0-0.81.3-1.31.31.31.31.31.31.3-1.31.31.51.2-1.2-2.01.32.0-1.91.9-1.8-1.4-2.21.3-1.11.11.10.81.41.41.41.4-1.4-1.4-1.41.4
Fecal boli incidents, locomotor time 10.10.10.40.20.00.0-0.20.3-0.30.30.30.30.30.30.3-0.30.40.30.3-0.3-0.50.30.5-0.50.4-0.4-0.3-0.60.3-0.30.30.30.30.30.30.30.3-0.3-0.4-0.40.4
Change in fecal boli incidents, locomotor task1.31.21.4-0.7-0.9-0.9-1.11.1-1.11.11.21.21.21.21.2-1.21.11.21.1-1.1-1.11.11.1-1.11.1-1.1-1.2-1.01.1-1.11.11.11.01.11.11.11.1-1.1-1.1-1.11.1
Time >=10cm from walls, locomotor time 10.00.00.1-0.1-0.1-0.1-0.10.1-0.10.10.20.20.20.20.2-0.20.30.20.1-0.2-0.20.20.2-0.20.2-0.2-0.2-0.20.2-0.10.10.10.30.10.10.10.1-0.1-0.1-0.10.1
Bouts of movement, locomotor time 12.02.22.7-1.4-1.6-1.6-1.71.5-1.51.51.41.41.41.41.4-1.41.51.51.5-1.6-1.31.61.3-1.41.4-1.4-1.6-1.21.6-1.51.51.51.51.51.51.51.5-1.5-1.6-1.61.6
Total resting periods, locomotor time 12.73.03.5-1.3-1.5-1.6-1.81.8-1.81.81.61.61.61.61.6-1.61.71.71.8-1.8-1.71.81.7-1.71.8-1.8-1.8-1.71.9-1.81.81.81.71.81.81.81.8-1.8-1.9-1.91.9
Rest time, locomotor task time 11.01.11.3-0.6-0.8-0.8-1.01.0-1.01.01.01.01.01.01.0-1.01.11.01.0-1.1-1.11.11.1-1.11.1-1.1-1.1-1.11.0-1.11.11.10.81.11.11.11.1-1.1-1.1-1.11.1
Distance moved, locomotor task time 11.41.52.10.30.60.71.0-1.21.2-1.2-1.2-1.2-1.2-1.2-1.21.2-1.1-1.3-1.21.11.4-1.2-1.41.4-1.31.41.21.5-1.21.3-1.3-1.3-0.7-1.3-1.3-1.3-1.31.31.31.3-1.3
Vertical activity count, locomotor time 10.50.50.80.00.20.30.5-0.70.7-0.7-0.7-0.7-0.7-0.7-0.70.7-0.4-0.7-0.70.60.9-0.7-0.80.8-0.80.80.70.9-0.70.8-0.8-0.8-0.4-0.8-0.8-0.8-0.80.80.80.8-0.8
Time >=10cm from walls, locomotor time 20.20.20.4-0.2-0.3-0.3-0.40.5-0.50.50.50.50.50.50.5-0.50.60.50.5-0.4-0.50.50.5-0.50.5-0.5-0.4-0.40.4-0.50.50.50.50.50.50.50.5-0.5-0.4-0.40.4
Bouts of movement, locomotor time 20.00.00.10.20.20.20.2-0.10.1-0.1-0.3-0.3-0.3-0.3-0.30.3-0.2-0.2-0.10.20.1-0.2-0.10.1-0.10.10.10.1-0.00.2-0.2-0.2-0.2-0.2-0.2-0.2-0.20.20.10.1-0.1
Total resting periods, locomotor time 20.00.00.00.0-0.0-0.0-0.00.1-0.10.10.00.00.00.00.0-0.00.10.00.1-0.1-0.10.10.1-0.10.1-0.1-0.1-0.10.2-0.10.10.1-0.10.10.10.10.1-0.1-0.2-0.20.2
Rest time, locomotor task time 20.10.10.20.1-0.0-0.1-0.20.3-0.30.30.40.40.40.40.4-0.40.20.30.3-0.3-0.40.30.4-0.40.4-0.4-0.3-0.40.3-0.40.40.40.20.40.40.40.4-0.4-0.3-0.30.3
Distance moved, locomotor task time 20.00.00.10.00.0-0.0-0.10.1-0.10.1-0.0-0.0-0.0-0.0-0.00.00.2-0.00.1-0.1-0.10.10.1-0.10.1-0.1-0.1-0.10.10.1-0.1-0.10.3-0.1-0.1-0.1-0.10.1-0.0-0.00.0
Vertical activity count, locomotor time 20.00.00.10.00.00.00.1-0.20.2-0.2-0.1-0.1-0.1-0.1-0.10.10.2-0.2-0.20.10.2-0.1-0.10.1-0.10.10.10.1-0.10.3-0.3-0.30.0-0.3-0.3-0.3-0.30.30.20.2-0.2
Light reinforcement 10.30.61.50.30.40.50.8-0.40.4-0.4-0.4-0.4-0.4-0.4-0.40.4-0.4-0.4-0.40.90.9-0.8-1.00.9-1.00.91.01.2-1.10.9-0.9-0.9-1.0-0.8-0.8-0.8-0.90.91.01.0-1.0
Light reinforcement 21.01.42.00.30.60.61.0-1.21.2-1.2-1.2-1.2-1.2-1.2-1.21.2-1.2-1.2-1.21.11.4-1.2-1.31.3-1.31.31.11.4-1.11.2-1.2-1.2-1.0-1.2-1.2-1.2-1.21.21.11.1-1.1
Bone: marrow area0.00.00.1-0.4-0.3-0.3-0.10.0-0.00.0-0.1-0.1-0.1-0.1-0.10.1-0.0-0.00.0-0.10.20.0-0.10.1-0.10.1-0.00.00.10.0-0.0-0.00.0-0.1-0.1-0.10.1-0.1-0.2-0.20.2
Bone: maximum diameter1.22.19.4-3.1-2.7-2.6-2.01.3-1.31.31.41.41.41.41.4-1.41.31.31.3-1.6-0.31.40.3-0.40.6-0.6-1.2-0.11.4-1.41.41.41.31.41.41.41.2-1.2-1.4-1.41.4
Bone: maximum force0.10.20.6-0.3-0.10.00.3-0.50.5-0.5-0.5-0.5-0.5-0.5-0.50.5-0.5-0.5-0.50.40.7-0.5-0.70.7-0.70.70.60.8-0.50.3-0.3-0.4-0.6-0.4-0.4-0.4-0.30.30.40.4-0.4
Bone: maximum moment0.30.51.1-0.30.00.10.5-0.80.8-0.8-0.8-0.8-0.8-0.8-0.80.8-0.7-0.7-0.70.61.0-0.7-1.01.0-1.00.90.81.1-0.60.6-0.6-0.6-0.8-0.6-0.6-0.6-0.50.50.60.6-0.6
Mean time between licks in bursts2.53.54.6-1.7-1.9-2.0-2.11.8-1.81.81.91.91.91.91.9-1.91.81.81.8-2.1-1.72.01.8-1.71.8-1.8-2.1-1.72.1-1.61.61.71.91.81.81.81.8-1.8-2.0-2.02.0
Mean num. licks in bursts3.23.86.50.2-0.5-0.6-1.42.4-2.42.42.32.32.32.32.3-2.32.22.22.2-1.7-2.52.02.4-2.52.3-2.4-1.8-2.31.6-1.81.81.81.31.71.71.71.7-1.7-1.6-1.61.6
Cd content in liver0.20.20.40.70.60.60.6-0.30.3-0.3-0.3-0.3-0.3-0.3-0.30.3-0.3-0.3-0.30.50.3-0.5-0.30.3-0.40.40.50.3-0.60.6-0.6-0.5-0.5-0.5-0.5-0.5-0.50.50.50.5-0.5
Co content in liver0.00.00.30.30.30.30.30.0-0.00.0-0.0-0.0-0.0-0.0-0.00.0-0.0-0.0-0.00.30.1-0.2-0.20.2-0.20.20.40.3-0.50.2-0.2-0.2-0.4-0.2-0.2-0.2-0.20.20.30.3-0.3
Cu content in liver0.10.10.5-0.7-0.6-0.6-0.40.2-0.20.20.10.10.10.10.1-0.10.10.10.1-0.3-0.00.30.1-0.10.1-0.1-0.3-0.10.3-0.40.40.40.70.40.40.40.4-0.4-0.4-0.40.4
Fe content in liver3.34.05.6-0.6-1.1-1.3-1.82.0-2.02.02.02.02.02.02.0-2.02.02.02.0-2.0-2.32.12.4-2.32.3-2.3-2.2-2.41.9-2.02.02.02.12.02.02.02.0-2.0-2.0-2.02.0
K content in liver2.02.04.20.30.60.81.3-1.21.2-1.2-1.2-1.2-1.2-1.2-1.21.2-1.2-1.2-1.21.51.7-1.5-1.91.7-1.81.71.82.0-1.71.4-1.4-1.4-1.5-1.4-1.4-1.4-1.41.41.61.6-1.6
Mg content in liver0.10.10.7-0.1-0.00.10.3-0.00.0-0.00.00.00.00.00.0-0.0-0.00.0-0.00.40.4-0.3-0.60.5-0.50.40.60.9-0.70.2-0.2-0.2-0.5-0.1-0.1-0.1-0.10.10.50.5-0.5
Mn content in liver2.12.44.10.81.11.31.6-1.31.3-1.3-1.3-1.3-1.3-1.3-1.31.3-1.3-1.3-1.31.71.7-1.7-1.91.7-1.81.72.02.0-2.01.5-1.5-1.5-1.8-1.5-1.5-1.5-1.51.51.81.8-1.8
Na content in liver1.81.95.5-2.3-2.2-2.1-1.71.4-1.41.41.41.41.41.41.4-1.41.41.41.4-1.5-0.61.30.6-0.70.8-0.9-1.2-0.41.3-1.41.41.41.31.41.41.41.4-1.4-1.4-1.41.4
Rb content in liver0.40.42.7-1.2-0.8-0.60.1-0.30.3-0.3-0.2-0.2-0.2-0.2-0.20.2-0.3-0.2-0.30.41.2-0.5-1.31.1-1.11.00.81.7-0.70.5-0.5-0.4-0.4-0.4-0.4-0.4-0.40.40.70.7-0.7
Se content in liver0.20.21.3-0.8-0.5-0.40.1-0.10.1-0.1-0.0-0.0-0.0-0.0-0.00.0-0.1-0.0-0.10.30.8-0.3-0.90.7-0.80.60.61.1-0.60.2-0.2-0.2-0.5-0.2-0.2-0.2-0.20.20.40.4-0.4
Sr content in liver1.61.52.9-1.7-1.7-1.7-1.51.2-1.21.21.21.21.21.21.2-1.21.21.21.2-1.4-0.81.30.8-0.90.9-1.0-1.2-0.81.3-1.21.21.21.31.21.21.21.2-1.2-1.3-1.31.3
Zn content in liver0.10.10.4-0.2-0.1-0.00.20.1-0.10.10.00.00.00.00.0-0.00.00.00.00.30.4-0.2-0.50.4-0.40.30.50.7-0.50.2-0.2-0.2-0.4-0.2-0.2-0.2-0.20.20.30.3-0.3
Bone: minimum diameter0.10.20.40.20.30.30.5-0.50.5-0.5-0.5-0.5-0.5-0.5-0.50.5-0.5-0.5-0.50.50.5-0.5-0.60.5-0.50.50.60.5-0.50.3-0.3-0.4-0.6-0.4-0.4-0.4-0.50.50.50.5-0.5
Time in familiar zone, hab. session 10.10.00.20.40.40.40.3-0.20.2-0.2-0.2-0.2-0.2-0.2-0.20.2-0.2-0.2-0.20.30.1-0.2-0.10.1-0.10.10.20.1-0.30.2-0.2-0.1-0.3-0.1-0.1-0.1-0.10.10.20.2-0.2
Time in novel zone, hab. session 10.30.30.6-0.3-0.00.00.3-0.60.6-0.6-0.5-0.5-0.5-0.5-0.50.5-0.5-0.6-0.60.40.8-0.5-0.70.8-0.70.70.50.8-0.40.5-0.5-0.6-0.4-0.6-0.6-0.6-0.50.50.50.5-0.5
Total zone transitions, hab. session 10.00.10.1-0.1-0.2-0.2-0.20.2-0.20.20.30.30.30.30.3-0.30.30.30.3-0.2-0.30.20.2-0.20.2-0.2-0.2-0.10.2-0.40.40.30.10.30.30.30.1-0.1-0.0-0.00.0
Total locomotion distance, hab. session 10.10.10.5-0.1-0.1-0.00.10.2-0.20.20.20.20.20.20.2-0.20.20.20.20.20.2-0.1-0.40.2-0.30.20.40.7-0.40.1-0.1-0.2-0.4-0.3-0.3-0.3-0.50.50.70.7-0.7
Locomotion velocity, hab. session 10.20.20.6-0.3-0.4-0.3-0.40.7-0.70.70.80.80.80.80.8-0.80.80.70.7-0.4-0.40.50.3-0.40.4-0.4-0.3-0.00.2-0.40.40.30.20.20.20.20.1-0.10.00.0-0.0
Time in familiar zone, hab. session 20.10.10.90.90.70.60.2-0.10.1-0.1-0.1-0.1-0.1-0.1-0.10.1-0.2-0.1-0.10.0-0.40.00.5-0.40.4-0.3-0.2-0.70.20.2-0.2-0.20.2-0.2-0.2-0.2-0.20.2-0.0-0.00.0
Time in novel zone, hab. session 20.10.11.2-1.1-0.8-0.7-0.20.1-0.10.10.00.00.00.00.0-0.00.10.00.10.00.6-0.1-0.70.5-0.50.40.30.8-0.3-0.20.20.2-0.20.20.20.20.2-0.20.10.1-0.1
Total zone transitions, hab. session 20.20.20.6-0.8-0.7-0.7-0.50.6-0.60.60.60.60.60.60.6-0.60.60.60.6-0.4-0.10.40.0-0.10.1-0.2-0.20.30.1-0.40.40.30.00.30.30.30.2-0.2-0.0-0.00.0
Total locomotion distance, hab. session 20.60.81.3-1.1-1.1-1.1-0.91.1-1.11.11.21.21.21.21.2-1.21.11.21.1-0.8-0.60.90.5-0.60.6-0.7-0.6-0.10.6-0.90.90.80.50.70.70.70.5-0.5-0.4-0.40.4
Locomotion velocity, hab. session 20.40.61.4-1.2-1.2-1.1-0.91.0-1.01.01.11.11.11.11.1-1.11.01.01.0-0.7-0.40.70.3-0.40.4-0.5-0.50.10.5-0.70.70.60.40.60.60.60.3-0.3-0.3-0.30.3
Novel to familiar place preference ratio1.51.52.3-1.5-1.5-1.5-1.41.3-1.31.31.31.31.31.31.3-1.31.31.21.3-1.3-0.91.20.9-0.91.0-1.0-1.2-0.81.3-1.21.21.11.21.11.11.11.1-1.1-1.3-1.31.3
Novelty place preference1.51.52.4-1.5-1.5-1.5-1.41.2-1.21.21.31.31.31.31.3-1.31.21.21.2-1.3-0.81.20.9-0.91.0-1.0-1.2-0.81.3-1.21.21.11.21.21.21.21.2-1.2-1.3-1.31.3
Time in novel zone, NPP test1.41.42.2-1.5-1.5-1.5-1.41.2-1.21.21.21.21.21.21.2-1.21.21.21.2-1.3-0.81.20.8-0.90.9-1.0-1.2-0.81.2-1.21.21.11.21.11.11.11.1-1.1-1.3-1.31.3
Total zone transitions, NPP test0.50.81.51.21.11.21.1-0.70.7-0.7-0.8-0.8-0.8-0.8-0.80.8-0.7-0.7-0.81.00.6-0.9-0.70.6-0.70.71.00.8-1.10.7-0.7-0.7-1.2-0.8-0.8-0.8-0.90.91.21.2-1.2
Total locomotion distance, NPP test0.10.20.60.50.50.50.5-0.20.2-0.2-0.2-0.2-0.2-0.2-0.20.2-0.2-0.2-0.20.50.2-0.4-0.30.3-0.30.30.50.5-0.60.4-0.4-0.4-0.6-0.5-0.5-0.5-0.70.70.80.8-0.8
Locomotion velocity, NPP test0.10.10.40.30.30.30.3-0.10.1-0.1-0.2-0.2-0.2-0.2-0.20.2-0.1-0.2-0.20.30.2-0.3-0.30.2-0.30.30.40.5-0.40.4-0.4-0.4-0.4-0.5-0.5-0.5-0.60.60.70.7-0.7
Intraocular pressure1.21.72.5-1.2-1.3-1.3-1.41.4-1.41.41.51.51.51.51.5-1.51.61.51.5-1.3-1.11.41.1-1.21.2-1.2-1.2-1.01.2-1.21.21.11.11.21.21.21.1-1.1-1.4-1.41.4
Delta distance traveled before/after self-admin0.10.10.30.30.20.1-0.10.3-0.30.30.30.30.30.30.3-0.30.30.30.3-0.2-0.50.30.5-0.50.5-0.4-0.3-0.60.2-0.20.20.20.50.20.20.20.2-0.2-0.2-0.20.2
Delta ambulatory time before/after self-admin0.10.10.40.60.40.40.10.2-0.20.20.20.20.20.20.2-0.20.20.20.2-0.1-0.50.20.5-0.50.4-0.4-0.2-0.70.2-0.00.00.00.30.10.10.10.1-0.1-0.1-0.10.1
Parametrial fat weight2.54.88.1-2.8-2.8-2.8-2.72.0-2.02.02.12.12.12.12.1-2.12.22.12.0-2.5-1.62.31.7-1.71.8-1.8-2.4-1.62.6-2.12.12.12.72.12.12.12.2-2.2-2.3-2.32.3
Pavlov. Cond. lever latency0.60.71.4-1.2-1.2-1.2-1.10.8-0.80.80.70.70.70.70.7-0.70.80.80.8-1.0-0.50.90.6-0.60.7-0.7-1.0-0.51.0-0.80.80.81.00.80.80.80.9-0.9-0.9-0.90.9
Pavlov. Cond. magazine entry latency0.20.32.91.71.41.40.9-0.30.3-0.3-0.3-0.3-0.3-0.3-0.30.3-0.4-0.4-0.40.6-0.2-0.50.1-0.1-0.0-0.00.5-0.3-0.70.2-0.2-0.1-0.8-0.1-0.1-0.1-0.30.30.50.5-0.5
Pavlov. Cond. change in total contacts0.20.20.5-0.7-0.7-0.6-0.40.4-0.40.40.40.40.40.40.4-0.40.40.40.4-0.3-0.10.30.0-0.10.1-0.2-0.2-0.10.2-0.60.60.60.10.60.60.60.6-0.6-0.5-0.50.5
Pavlov. Cond. index score0.40.53.41.81.61.51.1-0.50.5-0.5-0.4-0.4-0.4-0.4-0.40.4-0.5-0.5-0.50.8-0.1-0.6-0.0-0.0-0.10.10.7-0.2-0.90.4-0.4-0.3-0.9-0.3-0.3-0.3-0.50.50.60.6-0.6
Pavlov. Cond. latency score0.40.52.91.71.51.41.0-0.60.6-0.6-0.5-0.5-0.5-0.5-0.50.5-0.6-0.5-0.60.8-0.0-0.6-0.10.1-0.20.20.7-0.1-0.80.4-0.4-0.4-0.9-0.4-0.4-0.4-0.60.60.60.6-0.6
Pavlov. Cond. lever contacts0.20.21.61.21.11.10.8-0.30.3-0.3-0.2-0.2-0.2-0.2-0.20.2-0.3-0.2-0.30.6-0.0-0.4-0.10.0-0.20.10.60.0-0.70.3-0.3-0.3-0.8-0.2-0.2-0.2-0.40.40.50.5-0.5
Pavlov. Cond. magazine entry number0.20.22.6-1.6-1.2-1.1-0.6-0.10.1-0.1-0.1-0.1-0.1-0.1-0.10.1-0.1-0.1-0.1-0.30.70.1-0.60.6-0.40.5-0.10.70.40.3-0.3-0.30.4-0.3-0.3-0.3-0.30.3-0.1-0.10.1
Pavlov. Cond. intertrial magazine entries1.31.62.50.00.40.50.9-1.41.4-1.4-1.4-1.4-1.4-1.4-1.41.4-1.4-1.4-1.41.11.6-1.3-1.51.5-1.51.51.21.4-1.01.3-1.3-1.3-0.9-1.3-1.3-1.3-1.31.31.01.0-1.0
Pavlov. Cond. lever-magazine prob. diff.0.40.53.92.01.71.61.1-0.50.5-0.5-0.4-0.4-0.4-0.4-0.40.4-0.5-0.5-0.50.8-0.2-0.60.0-0.0-0.10.10.7-0.2-0.90.4-0.4-0.4-1.0-0.3-0.3-0.3-0.40.40.60.6-0.6
Pavlov. Cond. response bias0.20.22.11.41.21.20.8-0.10.1-0.1-0.1-0.1-0.1-0.1-0.10.1-0.2-0.2-0.20.6-0.2-0.40.0-0.1-0.10.00.6-0.1-0.80.0-0.0-0.0-0.90.00.00.0-0.10.10.50.5-0.5
Pavlov. Cond. lever latency1.41.85.0-1.2-0.5-0.30.6-1.31.3-1.3-1.2-1.2-1.2-1.2-1.21.2-1.3-1.3-1.31.12.1-1.3-2.12.0-1.91.91.42.2-1.11.2-1.2-1.2-0.8-1.3-1.3-1.3-1.31.31.11.1-1.1
Pavlov. Cond. magazine entry latency0.10.10.30.40.40.40.4-0.60.6-0.6-0.5-0.5-0.5-0.5-0.50.5-0.6-0.6-0.60.30.3-0.4-0.20.3-0.30.30.3-0.0-0.20.0-0.0-0.0-0.30.00.00.00.0-0.00.00.0-0.0
Pavlov. Cond. change in total contacts0.20.30.70.1-0.0-0.1-0.40.4-0.40.40.30.30.30.30.3-0.30.40.40.4-0.5-0.70.50.7-0.70.7-0.6-0.6-0.80.6-0.50.50.50.50.60.60.60.6-0.6-0.6-0.60.6
Pavlov. Cond. index score0.20.31.30.90.50.4-0.10.4-0.40.40.40.40.40.40.4-0.40.30.30.3-0.3-0.90.40.9-0.90.8-0.8-0.5-1.10.4-0.50.50.50.20.60.60.60.6-0.6-0.5-0.50.5
Pavlov. Cond. latency score0.20.21.01.00.70.60.10.2-0.20.20.20.20.20.20.2-0.20.10.10.1-0.1-0.70.20.7-0.70.6-0.6-0.3-1.00.2-0.30.30.40.00.40.40.40.4-0.4-0.4-0.40.4
Pavlov. Cond. lever contacts1.11.54.31.00.40.2-0.61.1-1.11.11.11.11.11.11.1-1.11.11.11.1-1.0-1.91.21.9-1.81.8-1.7-1.3-2.11.2-1.01.01.00.91.11.11.11.1-1.1-1.1-1.11.1
Pavlov. Cond. magazine entry number0.20.20.50.00.10.20.3-0.30.3-0.3-0.2-0.2-0.2-0.2-0.20.2-0.2-0.2-0.20.40.5-0.4-0.50.5-0.50.50.40.7-0.40.6-0.6-0.7-0.4-0.7-0.7-0.7-0.70.70.60.6-0.6
Pavlov. Cond. intertrial magazine entries0.10.10.2-0.1-0.2-0.2-0.30.5-0.50.50.50.50.50.50.5-0.50.50.50.5-0.3-0.30.30.3-0.30.3-0.3-0.2-0.10.1-0.10.10.00.10.10.10.10.1-0.1-0.0-0.00.0
Pavlov. Cond. lever-magazine prob. diff.0.10.20.91.00.70.60.10.1-0.10.10.10.10.10.10.1-0.10.10.10.1-0.1-0.70.20.7-0.60.6-0.5-0.3-0.90.2-0.30.30.3-0.00.40.40.40.4-0.4-0.3-0.30.3
Pavlov. Cond. response bias0.81.22.90.40.0-0.1-0.71.0-1.01.01.01.01.01.01.0-1.01.01.01.0-1.0-1.51.11.6-1.51.5-1.4-1.2-1.71.1-1.01.01.00.91.11.11.11.1-1.1-1.0-1.01.0
Time in closed arm before self-admin0.40.51.0-0.3-0.00.10.4-0.60.6-0.6-0.5-0.5-0.5-0.5-0.50.5-0.6-0.6-0.60.60.9-0.6-0.90.9-0.90.80.71.0-0.80.8-0.8-0.8-0.7-0.8-0.8-0.8-0.80.80.90.9-0.9
Time in closed arm after self-admin1.11.12.61.61.61.51.2-1.01.0-1.0-0.9-0.9-0.9-0.9-0.90.9-1.0-1.0-1.01.00.5-1.0-0.50.5-0.60.70.90.4-1.11.2-1.2-1.2-0.7-1.2-1.2-1.2-1.21.21.31.3-1.3
Time in open arm before self-admin0.20.21.81.41.00.90.40.0-0.00.00.10.10.10.10.1-0.10.00.00.00.1-0.70.00.7-0.60.5-0.5-0.1-0.90.3-0.20.20.20.20.20.20.20.2-0.2-0.3-0.30.3
Time in open arm after self-admin2.42.73.3-1.3-1.5-1.5-1.61.7-1.71.71.61.61.61.61.6-1.61.71.71.7-1.6-1.41.61.4-1.41.4-1.5-1.5-1.31.7-1.81.81.81.31.81.81.81.8-1.8-1.8-1.81.8
Bone: periosteal estimation0.10.21.4-1.2-0.8-0.7-0.2-0.20.2-0.2-0.2-0.2-0.2-0.2-0.20.2-0.2-0.2-0.20.00.7-0.2-0.70.7-0.60.60.20.7-0.10.1-0.1-0.1-0.2-0.1-0.1-0.1-0.10.1-0.0-0.00.0
Bone: periosteal perimeter0.10.22.3-1.5-1.2-1.1-0.5-0.00.0-0.00.00.00.00.00.0-0.00.00.00.0-0.20.60.1-0.60.5-0.40.4-0.00.70.2-0.10.10.10.10.10.10.1-0.10.1-0.1-0.10.1
Bone: post-yield work0.00.00.2-0.4-0.3-0.3-0.10.0-0.00.00.00.00.00.00.0-0.00.10.00.1-0.10.10.0-0.20.1-0.10.10.00.2-0.0-0.20.20.2-0.10.20.20.20.1-0.1-0.1-0.10.1
Progressive ratio test 1 active lever presses0.20.20.5-0.5-0.5-0.5-0.50.5-0.50.50.30.30.30.30.3-0.30.70.70.5-0.5-0.40.50.4-0.40.4-0.4-0.4-0.30.3-0.50.50.50.50.50.50.50.5-0.5-0.5-0.50.5
Progressive ratio test 1 breakpoint0.10.10.3-0.1-0.2-0.2-0.20.3-0.30.30.10.10.10.10.1-0.10.50.50.3-0.3-0.30.30.3-0.30.3-0.3-0.2-0.20.1-0.40.40.30.20.30.30.30.3-0.3-0.3-0.30.3
Progressive ratio test 1 inactive lever presses0.20.22.0-1.4-1.2-1.1-0.70.4-0.40.4-0.1-0.1-0.1-0.1-0.10.10.40.40.4-0.50.20.4-0.10.1-0.0-0.0-0.30.30.4-0.40.40.50.50.50.50.50.4-0.4-0.4-0.40.4
Progressive ratio test 2 active lever presses0.10.10.3-0.4-0.4-0.3-0.20.2-0.20.20.40.40.40.40.4-0.40.50.50.2-0.2-0.10.2-0.0-0.10.1-0.1-0.00.00.0-0.30.30.3-0.00.20.20.20.2-0.2-0.2-0.20.2
Progressive ratio test 2 breakpoint0.30.30.8-0.5-0.6-0.5-0.50.6-0.60.60.60.60.60.60.6-0.60.90.90.6-0.4-0.40.50.3-0.40.3-0.4-0.3-0.20.3-0.60.60.60.20.60.60.60.5-0.5-0.5-0.50.5
Progressive ratio test 2 inactive lever presses1.41.62.4-1.4-1.5-1.4-1.41.3-1.31.31.41.41.41.41.4-1.41.51.51.3-1.3-1.01.30.9-1.01.0-1.1-1.1-0.81.2-1.31.31.31.21.31.31.31.3-1.3-1.3-1.31.3
Incentive Sensitization - Responses0.20.20.3-0.5-0.5-0.5-0.50.5-0.50.50.50.50.50.50.5-0.50.60.60.5-0.5-0.40.50.4-0.40.4-0.5-0.5-0.40.4-0.50.50.50.50.50.50.50.5-0.5-0.5-0.50.5
Incentive Sensitization - Breakpoint0.20.20.3-0.4-0.5-0.5-0.50.5-0.50.50.40.40.40.40.4-0.40.50.50.5-0.5-0.40.50.4-0.40.4-0.4-0.5-0.40.4-0.50.50.50.50.50.50.50.5-0.5-0.5-0.50.5
Sum of active levers in priming session hrs 5-60.10.10.3-0.6-0.5-0.5-0.30.3-0.30.30.30.30.30.30.3-0.30.30.30.3-0.20.00.2-0.10.0-0.0-0.0-0.00.10.2-0.20.20.2-0.30.30.30.30.2-0.2-0.2-0.20.2
Progressive ratio0.30.30.70.30.50.50.6-0.40.4-0.4-0.7-0.7-0.7-0.7-0.70.7-0.7-0.8-0.50.60.6-0.6-0.60.6-0.60.60.60.5-0.60.5-0.5-0.5-0.8-0.5-0.5-0.5-0.50.50.50.5-0.5
Food seeking constrained by brief footshock2.63.25.9-0.30.40.51.3-1.81.8-1.8-1.6-1.6-1.6-1.6-1.61.6-1.9-1.7-1.91.62.4-1.8-2.42.3-2.32.21.82.4-1.72.0-2.0-2.0-1.6-1.8-1.8-1.8-1.81.81.81.8-1.8
Seeking ratio, punishment vs. effort0.20.20.8-0.5-0.3-0.20.1-0.60.6-0.6-0.3-0.3-0.3-0.3-0.30.3-0.3-0.1-0.60.30.7-0.4-0.70.7-0.60.60.40.9-0.30.5-0.5-0.5-0.1-0.5-0.5-0.5-0.50.50.40.4-0.4
Retroperitoneal fat weight0.20.61.0-0.3-0.5-0.5-0.70.9-0.90.90.90.90.90.90.9-0.91.00.90.9-0.7-0.80.80.8-0.80.8-0.8-0.8-0.70.7-0.60.60.51.00.50.50.50.5-0.5-0.6-0.60.6
Reaction time number correct0.50.81.0-0.5-0.7-0.7-0.81.0-1.01.00.90.90.90.90.9-0.91.01.01.0-0.8-0.90.90.8-0.90.8-0.9-0.7-0.80.7-1.01.01.00.61.01.01.01.0-1.0-0.8-0.80.8
Reaction time mean minus median1.01.32.80.4-0.0-0.2-0.81.1-1.11.11.11.11.11.11.1-1.11.11.11.1-1.1-1.61.21.7-1.61.6-1.5-1.3-1.71.2-1.01.01.01.41.01.01.01.0-1.0-1.0-1.01.0
Reaction time mean minus median AUC0.10.20.60.70.40.4-0.10.4-0.40.40.40.40.40.40.4-0.40.40.40.4-0.3-0.80.40.8-0.70.7-0.7-0.4-0.70.2-0.20.20.20.50.20.20.20.2-0.2-0.1-0.10.1
Reaction time num false alarms0.60.81.40.40.60.70.9-0.90.9-0.9-0.8-0.8-0.8-0.8-0.80.8-0.8-0.8-0.81.01.0-1.0-1.11.0-1.11.01.11.1-1.20.8-0.8-0.8-1.0-0.8-0.8-0.8-0.80.81.01.0-1.0
Reaction time num false alarms AUC1.31.82.70.81.01.11.4-1.41.4-1.4-1.3-1.3-1.3-1.3-1.31.3-1.3-1.3-1.21.51.4-1.4-1.51.5-1.51.51.61.5-1.61.3-1.3-1.3-1.4-1.3-1.3-1.3-1.31.31.51.5-1.5
Reaction time trials correct on left0.50.81.0-0.5-0.7-0.7-0.81.0-1.01.00.90.90.90.90.9-0.91.01.01.0-0.8-0.90.90.8-0.90.8-0.9-0.7-0.80.7-1.01.01.00.61.01.01.01.0-1.0-0.8-0.80.8
Reaction time trials on left0.50.70.9-0.4-0.6-0.6-0.81.0-1.01.00.90.90.90.90.9-0.90.90.90.9-0.8-0.90.80.8-0.90.8-0.9-0.7-0.80.7-0.90.91.00.60.90.90.90.9-0.9-0.8-0.80.8
Reaction time mean0.10.20.70.50.30.1-0.20.4-0.40.40.40.40.40.40.4-0.40.40.40.4-0.4-0.80.50.8-0.80.8-0.7-0.6-0.80.4-0.20.20.20.60.10.10.10.1-0.1-0.2-0.20.2
Reaction time mean AUC0.10.10.70.80.60.50.10.1-0.10.10.10.10.10.10.1-0.10.10.10.1-0.1-0.60.20.6-0.50.5-0.4-0.3-0.60.20.1-0.1-0.10.4-0.2-0.2-0.2-0.20.20.10.1-0.1
Median of all reaction times0.00.10.30.40.20.1-0.10.1-0.10.10.10.10.10.10.1-0.10.20.20.1-0.2-0.40.20.5-0.40.5-0.4-0.4-0.40.30.0-0.0-0.00.4-0.1-0.1-0.1-0.10.10.00.0-0.0
Reaction time omissions0.10.11.51.21.00.90.5-0.10.1-0.1-0.0-0.0-0.0-0.0-0.00.0-0.0-0.0-0.10.3-0.4-0.20.3-0.30.2-0.20.1-0.4-0.10.2-0.2-0.3-0.4-0.2-0.2-0.2-0.20.20.20.2-0.2
Reaction time false alarm rate2.33.23.71.01.31.41.7-1.91.9-1.9-1.8-1.8-1.8-1.8-1.81.8-1.8-1.8-1.81.81.9-1.9-1.91.9-1.91.91.91.9-1.91.8-1.8-1.8-1.7-1.8-1.8-1.8-1.81.81.91.9-1.9
Reaction time premature initiation rate1.41.95.52.32.22.11.8-1.11.1-1.1-1.3-1.3-1.3-1.3-1.31.3-1.2-1.2-1.21.50.6-1.3-0.70.7-0.80.91.30.6-1.51.4-1.4-1.4-1.4-1.4-1.4-1.4-1.41.41.61.6-1.6
Reaction time premature initiations0.40.52.61.61.41.41.0-0.30.3-0.3-0.5-0.5-0.5-0.5-0.50.5-0.4-0.4-0.40.80.0-0.6-0.20.1-0.30.20.70.1-0.90.6-0.6-0.7-0.9-0.7-0.7-0.7-0.60.60.80.8-0.8
Std. dev. reaction times0.71.02.40.4-0.0-0.2-0.71.0-1.01.01.01.01.01.01.0-1.01.01.01.0-1.0-1.51.11.5-1.51.4-1.4-1.2-1.51.1-0.80.80.71.30.70.70.70.7-0.7-0.8-0.80.8
Reaction time trials completed0.50.70.9-0.4-0.6-0.6-0.81.0-1.01.00.90.90.90.90.9-0.90.90.90.9-0.8-0.90.80.8-0.90.8-0.9-0.7-0.80.7-0.90.91.00.60.90.90.90.9-0.9-0.8-0.80.8
Reaction time trials AUC0.40.60.8-0.5-0.6-0.6-0.70.9-0.90.90.80.80.80.80.8-0.80.80.80.8-0.7-0.70.80.7-0.70.7-0.8-0.6-0.70.6-0.90.90.90.50.90.90.90.9-0.9-0.8-0.80.8
Run reversals in cocaine runway, females0.10.10.50.70.50.50.20.0-0.00.00.00.00.00.00.0-0.0-0.2-0.20.00.0-0.40.00.4-0.30.3-0.3-0.2-0.50.3-0.00.00.00.20.00.00.00.0-0.0-0.1-0.10.1
Run reversals in cocaine runway, males0.10.10.2-0.5-0.3-0.3-0.0-0.20.2-0.20.10.10.10.10.1-0.1-0.2-0.1-0.20.10.5-0.2-0.40.4-0.40.40.20.4-0.10.3-0.3-0.30.1-0.1-0.1-0.1-0.10.10.10.1-0.1
Latency to leave start box in cocaine runway0.50.50.80.30.50.50.7-0.90.9-0.9-0.6-0.6-0.6-0.6-0.60.6-0.7-0.8-0.80.70.8-0.8-0.80.8-0.80.80.80.8-0.70.7-0.7-0.7-0.6-0.9-0.9-0.9-0.90.90.80.8-0.8
Latency to leave start box in cocaine runway, F0.91.01.50.10.40.40.8-1.01.0-1.0-1.0-1.0-1.0-1.0-1.01.0-0.9-0.9-1.10.91.2-1.0-1.21.2-1.21.21.01.2-0.91.0-1.0-1.0-1.1-1.0-1.0-1.0-1.01.01.01.0-1.0
Latency to leave start box in cocaine runway, M0.10.10.30.50.30.30.10.0-0.00.00.40.40.40.40.4-0.40.1-0.10.1-0.0-0.40.10.3-0.30.3-0.3-0.1-0.30.0-0.20.20.20.60.00.00.00.0-0.0-0.0-0.00.0
Std. dev. time between licks in bursts0.10.10.3-0.1-0.1-0.2-0.30.0-0.00.00.10.10.10.10.1-0.10.10.10.1-0.3-0.30.30.4-0.30.4-0.3-0.4-0.60.5-0.30.30.30.60.40.40.40.4-0.4-0.5-0.50.5
Total sessions with >9 infusions0.30.40.80.40.50.60.7-0.60.6-0.6-0.4-0.4-0.4-0.4-0.40.4-0.4-0.4-0.60.80.7-0.7-0.80.7-0.80.70.90.7-0.90.6-0.6-0.6-0.9-0.6-0.6-0.6-0.60.60.70.7-0.7
Short access day 1 total inactive lever presses0.60.72.5-1.3-0.8-0.60.1-0.60.6-0.6-0.7-0.7-0.7-0.7-0.70.7-0.5-0.5-0.60.51.4-0.7-1.41.3-1.31.20.81.6-0.70.6-0.6-0.6-0.5-0.6-0.6-0.6-0.60.60.60.6-0.6
Short access day 10 total inactive lever presses0.20.20.70.70.70.60.4-0.50.5-0.5-0.8-0.8-0.8-0.8-0.80.8-0.5-0.5-0.50.30.1-0.30.00.1-0.10.20.1-0.1-0.10.5-0.5-0.5-0.1-0.4-0.4-0.4-0.40.40.40.4-0.4
Short access day 1 total infusions1.01.11.60.80.91.01.1-1.01.0-1.0-1.3-1.3-1.3-1.3-1.31.3-0.8-0.8-1.01.11.0-1.1-1.01.0-1.01.01.21.0-1.21.0-1.0-1.0-1.0-1.0-1.0-1.0-1.01.01.11.1-1.1
Short access day 10 total infusions0.60.71.10.50.60.70.8-0.90.9-0.9-0.9-0.9-0.9-0.9-0.90.9-0.5-0.6-0.90.80.8-0.8-0.90.8-0.80.80.90.9-1.00.8-0.8-0.8-1.0-0.8-0.8-0.8-0.90.90.80.8-0.8
Short access total infusions1.41.62.30.91.01.11.3-1.31.3-1.3-1.3-1.3-1.3-1.3-1.31.3-0.9-0.9-1.31.31.2-1.3-1.31.2-1.31.31.41.2-1.51.2-1.2-1.2-1.5-1.3-1.3-1.3-1.31.31.31.3-1.3
Short access day 1 locomotion3.13.34.91.92.02.12.1-1.81.8-1.8-1.8-1.8-1.8-1.8-1.81.8-1.8-1.8-1.82.01.5-1.9-1.61.6-1.61.61.91.4-2.01.8-1.8-1.8-2.2-1.8-1.8-1.8-1.81.81.91.9-1.9
Short access day 10 total locomotion0.70.81.20.91.01.01.0-0.90.9-0.9-0.6-0.6-0.6-0.6-0.60.6-0.8-0.8-0.91.00.7-0.9-0.70.7-0.80.80.90.7-1.00.9-0.9-0.9-1.1-0.9-0.9-0.9-1.01.01.01.0-1.0
Short access total locomotion2.42.54.62.22.12.11.9-1.61.6-1.6-1.4-1.4-1.4-1.4-1.41.4-1.3-1.3-1.61.71.0-1.6-1.11.1-1.21.21.60.9-1.81.6-1.6-1.6-1.9-1.6-1.6-1.6-1.71.71.71.7-1.7
One hour access (0.3 mA shock)0.00.00.2-0.2-0.2-0.1-0.10.1-0.10.10.40.40.40.40.4-0.40.50.50.1-0.00.00.1-0.10.0-0.10.00.10.2-0.0-0.10.10.2-0.30.20.20.20.1-0.1-0.1-0.10.1
Compulsive drug intake0.40.42.61.61.41.30.9-0.50.5-0.5-0.4-0.4-0.4-0.4-0.40.4-0.6-0.6-0.50.6-0.1-0.50.1-0.0-0.00.10.4-0.3-0.50.5-0.5-0.5-0.5-0.5-0.5-0.5-0.50.50.50.5-0.5
One hour access (shock baseline)0.40.51.6-1.3-1.2-1.1-0.80.7-0.70.70.80.80.80.80.8-0.81.01.00.7-0.6-0.20.60.1-0.20.2-0.3-0.30.10.5-0.70.70.70.30.70.70.70.7-0.7-0.6-0.60.6
Social response proportion3.63.95.1-2.1-2.2-2.3-2.22.0-2.02.02.02.02.02.02.0-2.02.12.12.1-2.1-1.62.11.6-1.71.8-1.8-2.0-1.51.9-1.81.81.82.11.91.91.91.9-1.9-2.0-2.02.0
Social responses2.93.75.3-2.2-2.3-2.3-2.22.1-2.12.12.12.12.12.12.1-2.12.12.12.1-2.0-1.42.01.4-1.51.6-1.6-1.8-1.21.8-1.81.81.81.91.91.91.91.9-1.9-1.9-1.91.9
Social time1.01.31.7-0.9-1.0-1.1-1.21.1-1.11.11.21.21.21.21.2-1.21.21.21.2-1.3-1.11.21.2-1.11.2-1.2-1.3-1.11.2-0.90.91.01.31.01.01.01.0-1.0-1.2-1.21.2
Soleus weight0.72.24.3-0.60.00.20.9-1.61.6-1.6-1.6-1.6-1.6-1.6-1.61.6-1.6-1.6-1.61.22.1-1.4-2.02.0-1.91.91.41.8-1.01.5-1.5-1.5-1.0-1.5-1.5-1.5-1.51.51.01.0-1.0
Bone: stiffness0.00.00.0-0.1-0.1-0.1-0.10.1-0.10.10.00.00.00.00.0-0.00.10.10.1-0.1-0.10.10.1-0.10.1-0.1-0.10.00.1-0.20.20.1-0.00.10.10.10.1-0.10.00.0-0.0
Tibialis anterior weight0.10.33.1-1.8-1.4-1.4-0.80.2-0.20.20.20.20.20.20.2-0.20.10.20.1-0.50.40.3-0.30.3-0.20.2-0.40.30.6-0.40.40.40.50.30.30.30.3-0.3-0.7-0.70.7
Time to tail flick, vehicle, before self-admin0.20.20.30.40.40.40.4-0.40.4-0.4-0.5-0.5-0.5-0.5-0.50.5-0.4-0.4-0.40.40.4-0.4-0.30.4-0.40.40.40.4-0.50.5-0.5-0.5-0.5-0.5-0.5-0.5-0.50.50.50.5-0.5
Time to tail flick, vehicle, after self-admin0.60.71.10.50.60.60.7-0.80.8-0.8-0.8-0.8-0.8-0.8-0.80.8-0.8-0.8-0.80.70.7-0.7-0.60.7-0.70.70.60.7-0.90.9-0.9-0.9-0.9-1.0-1.0-1.0-0.90.91.01.0-1.0
Time to tail flick, test, before self-admin0.10.10.40.70.60.50.4-0.20.2-0.2-0.1-0.1-0.1-0.1-0.10.1-0.2-0.2-0.20.3-0.0-0.20.00.0-0.00.10.2-0.1-0.20.2-0.2-0.20.1-0.2-0.2-0.2-0.20.20.20.2-0.2
Time to tail flick, test, after self-admin0.80.82.7-0.9-0.4-0.30.3-0.70.7-0.7-0.7-0.7-0.7-0.7-0.70.7-0.7-0.7-0.70.61.4-0.8-1.31.3-1.21.20.91.6-1.00.9-0.9-0.9-0.6-0.9-0.9-0.9-0.90.91.01.0-1.0
Delta time to tail flick, vehicle, before/after SA0.00.00.1-0.00.00.00.1-0.20.2-0.2-0.1-0.1-0.1-0.1-0.10.1-0.2-0.2-0.20.10.2-0.2-0.20.2-0.20.20.10.3-0.20.3-0.3-0.3-0.3-0.3-0.3-0.3-0.30.30.30.3-0.3
Delta time to tail flick, test, before/after SA0.10.11.0-1.0-0.8-0.8-0.50.2-0.20.20.10.10.10.10.1-0.10.20.20.2-0.30.30.2-0.20.2-0.10.1-0.10.50.1-0.10.10.10.00.10.10.10.1-0.10.00.0-0.0
Tibia length1.43.94.71.11.51.51.8-2.12.1-2.1-2.1-2.1-2.1-2.1-2.12.1-2.0-2.0-2.01.92.0-2.0-1.92.0-1.92.01.81.9-1.72.2-2.2-2.2-1.8-2.1-2.1-2.1-2.12.11.91.9-1.9
Ambulatory time before self-admin2.32.44.00.10.60.81.3-1.61.6-1.6-1.6-1.6-1.6-1.6-1.61.6-1.6-1.6-1.61.52.0-1.6-2.01.9-1.91.91.72.0-1.61.5-1.5-1.5-1.7-1.4-1.4-1.4-1.41.41.51.5-1.5
Ambulatory time after self-admin0.80.91.40.10.40.50.8-0.90.9-0.9-1.0-1.0-1.0-1.0-1.01.0-0.9-0.9-0.90.91.2-1.0-1.21.1-1.11.11.11.1-1.01.0-1.0-1.0-1.0-0.9-0.9-0.9-0.90.90.90.9-0.9
Bone: tissue strength0.10.10.3-0.4-0.4-0.4-0.40.1-0.10.10.10.10.10.10.1-0.10.10.10.1-0.4-0.20.30.3-0.20.3-0.2-0.4-0.40.5-0.30.30.20.50.30.30.30.4-0.4-0.5-0.50.5
Total heroin consumption0.00.00.1-0.3-0.2-0.2-0.1-0.00.0-0.0-0.0-0.0-0.0-0.0-0.00.00.00.00.0-0.00.2-0.0-0.20.2-0.10.10.10.30.00.0-0.0-0.0-0.4-0.1-0.1-0.1-0.10.10.20.2-0.2
Bone: trabecular number1.01.52.40.81.01.11.2-1.51.5-1.5-1.6-1.6-1.6-1.6-1.61.6-1.5-1.5-1.51.21.2-1.3-1.11.2-1.21.21.10.9-1.01.0-1.0-0.9-1.2-0.9-0.9-0.9-1.01.00.90.9-0.9
Bone: trabecular spacing0.60.82.0-1.4-1.4-1.3-1.11.1-1.11.11.21.21.21.21.2-1.21.11.11.1-0.9-0.50.90.4-0.50.5-0.6-0.7-0.10.7-0.60.60.60.80.50.50.50.6-0.6-0.6-0.60.6
Bone: trabecular thickness1.82.23.41.81.81.81.7-1.71.7-1.7-1.7-1.7-1.7-1.7-1.71.7-1.7-1.7-1.71.51.0-1.5-1.01.1-1.11.21.30.7-1.31.3-1.3-1.3-1.5-1.2-1.2-1.2-1.31.31.21.2-1.2
Bone: trabecular tissue density1.01.42.6-0.3-0.6-0.7-1.11.2-1.21.21.11.11.11.11.1-1.11.11.11.1-1.2-1.41.31.5-1.41.4-1.4-1.4-1.41.3-1.21.21.21.61.11.11.11.3-1.3-1.1-1.11.1
Water consumed over 24 hours1.82.23.1-1.7-1.8-1.7-1.61.6-1.61.61.51.51.51.51.5-1.51.51.51.5-1.5-1.11.51.1-1.21.2-1.2-1.4-1.01.4-1.61.61.61.31.51.51.51.5-1.5-1.4-1.41.4
Number of responses in last shaping day0.20.21.00.30.30.40.5-0.10.1-0.1-0.5-0.5-0.5-0.5-0.50.5-0.1-0.1-0.10.50.3-0.4-0.50.4-0.50.40.70.4-0.60.1-0.1-0.1-1.0-0.2-0.2-0.2-0.20.20.30.3-0.3