Hub : Genes

Nemp2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL intron excision ratio chr9_56359020_56361798 0.02 0.02 2.3e-03 0.01 0.01 0.01 0.01 8.3e-03 8.8e-03 2.4e-02 1.5e-02
2 NAcc gene expression Nemp2 0.03 0.03 2.5e-04 0.02 0.01 0.02 0.01 1.3e-03 9.8e-03 1.0e-03 8.5e-03
3 Adipose gene expression Nemp2 0.07 0.06 4.0e-04 -0 0.01 0 0 4.3e-01 8.5e-03 9.0e-02 1.4e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density1.83.35.9-1.92.4-0.4
Area under the delay curve0.10.10.20.2-0.5-0.0
BMI with tail3.813.321.04.6-2.73.4
BMI without tail0.63.25.71.8-0.72.4
Body weight0.10.40.7-0.3-0.8-0.6
Weight adjusted by age0.51.53.3-1.20.1-1.8
Bone surface0.50.91.0-1.00.8-1.0
Bone volume1.42.83.7-1.91.8-1.2
Breakpoint value in progressive ratio session0.30.61.4-1.20.3-0.5
Number of licking bursts0.31.02.20.50.71.5
Context. condit. distance diff. score1.72.14.01.3-0.72.0
Locomotion velocity, session 10.10.10.10.2-0.30.2
Locomotion distance, session 10.40.51.10.5-1.0-0.1
Locomotion velocity, session 21.11.32.11.5-1.40.3
Locomotion distance, session 20.71.02.00.9-1.4-0.3
Locomotion velocity, session 30.10.20.30.5-0.30.4
Locomotion distance, session 30.50.61.20.70.31.1
Stereotopy head waving bouts, day 30.40.50.70.8-0.80.3
Stereotopy head waving duration, day 30.10.10.20.2-0.4-0.0
Locomotion velocity, session 70.91.01.50.1-1.2-1.1
Locomotion distance, session 70.81.02.10.1-1.4-1.0
Stereotopy head waving bouts, day 70.10.10.2-0.40.40.0
Stereotopy head waving duration, day 70.40.50.7-0.90.8-0.3
Locomotion velocity, session 80.40.51.00.70.11.0
Locomotion distance, session 81.42.02.61.6-1.11.5
Degree of sensitization distance1.51.63.2-0.7-1.1-1.8
Degree of sensitization stereotypy0.20.20.5-0.40.70.2
Conditioned locomotion0.40.51.2-0.1-1.1-0.5
Cocaine response after cond. corrected0.91.32.3-0.1-1.5-1.3
Cocaine response after cond. not corrected1.82.65.3-1.1-1.1-2.3
Cocaine response before conditioning1.01.21.7-1.20.6-1.3
Saline control response0.30.40.60.20.70.8
Bone: connectivity density0.30.41.1-0.51.10.1
Bone: cortical apparent density4.26.79.73.1-2.91.5
Bone: cortical area0.61.02.10.2-1.5-0.9
Bone: cortical porosity1.82.04.4-1.32.10.1
Bone: cortical porosity2.52.74.8-1.82.2-0.6
Bone: cortical thickness1.62.64.11.8-2.00.7
Bone: cortical thickness0.20.20.40.1-0.6-0.6
Bone: cortical tissue density4.06.39.13.0-2.81.4
Condit. Reinf. active minus inactive responses2.83.25.9-2.40.8-1.7
Condit. Reinf. active-inactive response ratio1.61.73.3-1.80.5-1.3
Condit. Reinf. active responses2.73.45.6-2.40.3-2.1
Condit. Reinf. inactive responses0.50.61.0-0.4-0.8-1.0
Incentive salience index mean1.92.44.4-2.11.2-1.2
Condit. Reinf. lever presses0.30.50.8-0.80.90.1
Condit. Reinf. active minus inactive responses2.23.45.7-2.40.9-2.0
Condit. Reinf. active-inactive response ratio1.52.43.9-2.01.5-1.1
Condit. Reinf. active responses0.91.32.2-1.40.0-1.5
Condit. Reinf. inactive responses0.30.40.7-0.0-0.8-0.8
Condit. Reinf. lever presses0.10.20.3-0.40.5-0.2
Condit. Reinf. lever reinforcers received1.01.42.6-1.3-0.2-1.6
Conditioned reinforcement - actives0.00.10.10.3-0.40.2
Conditioned reinforcement - inactives0.10.20.3-0.3-0.3-0.6
Conditioned locomotion0.60.81.51.2-1.0-0.1
Patch foraging indifference point 0 sec1.43.86.92.6-0.22.1
Patch foraging indifference point AUC0.10.10.30.20.6-0.3
Delay disc. indifference point, 0s delay0.10.10.30.20.50.2
Delay disc. indifference point, 16s delay0.10.20.4-0.6-0.1-0.5
Delay disc. indifference point, 2s delay0.10.10.10.20.40.1
Delay disc. indifference point, 24s delay0.20.20.40.4-0.60.5
Delay disc. indifference point, 4s delay0.40.40.80.9-0.50.4
Delay disc. indifference point, 8s delay0.20.40.6-0.5-0.5-0.8
Indifference point function ln k0.41.22.21.1-0.51.5
Indifference point function log k0.41.22.21.1-0.51.5
Patch foraging total patch changes 0 sec1.33.86.62.60.12.2
Patch foraging total patch changes 12 sec0.30.30.60.80.50.3
Patch foraging total patch changes 18 sec0.71.62.81.70.41.3
Patch foraging total patch changes 24 sec0.20.81.31.10.60.8
Patch foraging total patch changes 6 sec1.83.15.82.40.01.8
Patch foraging time to switch 0 sec0.20.71.4-1.20.4-0.7
Patch foraging water rate 0 sec0.20.71.01.0-0.80.7
Patch foraging water rate 12 sec0.10.50.70.8-0.40.9
Patch foraging water rate 18 sec0.10.20.40.3-0.40.7
Patch foraging water rate 24 sec0.30.40.8-0.2-0.9-0.5
Patch foraging water rate 6 sec1.11.62.51.5-0.41.6
Seeking ratio, delayed vs. immediate footshock1.82.64.0-2.01.2-1.5
Distance traveled before self-admin2.35.17.4-2.72.1-1.8
Distance traveled after self-admin1.01.83.3-1.80.9-1.1
Extensor digitorum longus weight3.915.429.64.1-5.40.1
Bone: elastic displacement0.60.81.3-0.21.11.0
Bone: elastic work1.01.32.1-1.51.0-0.9
Bone: endosteal estimation2.86.79.3-3.01.5-3.0
Bone: endosteal perimeter1.02.64.2-1.90.2-2.0
Epididymis fat weight0.63.26.6-1.1-1.3-2.6
Delta time in closed arm before/after self-admin0.40.40.70.8-0.50.4
Delta time in open arm before/after self-admin3.13.75.2-2.32.1-1.2
Diff in mean of infusions in LGA sessions0.40.71.2-1.10.7-0.6
Delay discount exponential model param0.10.10.2-0.30.5-0.1
Extinction: sum of active levers before priming0.40.51.2-1.10.4-0.5
Active lever presses in extinction session 60.60.61.0-1.00.8-0.2
Bone: final force1.11.83.7-1.2-0.4-1.9
Bone: final moment0.71.12.3-0.8-0.5-1.5
Food consumed during 24 hour testing period0.40.81.4-0.90.5-1.2
Glucose0.81.33.10.80.61.8
Heart weight0.20.30.5-0.60.1-0.7
Delay discount hyperbolic model param0.10.10.2-0.40.4-0.2
Intermittent access intake day 1-15 change0.10.81.21.1-1.00.5
Intermittent access intake escalation0.21.32.11.4-1.00.9
Intermittent access intake escalation 20.30.40.60.8-0.20.8
Intermitt. access day 1 inactive lever presses0.33.45.42.1-0.52.3
Intermitt. access day 15 inactive lever presses0.00.20.20.5-0.50.5
Intermitt. access escalation Index0.20.71.20.7-1.10.5
Intermittent access day 1 total infusions0.00.10.2-0.30.50.3
Intermittent access day 15 total infusions0.71.72.51.6-0.91.4
Intermittent access terminal intake (last 3 days)1.32.33.51.9-0.81.6
Intermittent access total infusions0.30.40.60.7-0.20.8
Intermittent access day 1 locomotion0.00.00.00.00.00.0
Intermittent access day 15 total locomotion0.10.30.80.3-0.9-0.2
Intermittent access total locomotion0.40.50.80.9-0.40.7
Intermittent access standard deviation0.10.40.80.9-0.60.4
Left kidney weight0.00.10.2-0.50.0-0.3
Right kidney weight0.10.51.10.4-1.1-0.4
Cocaine induced anxiety0.51.42.11.4-1.30.7
Post-drug Anxiety1.21.42.61.2-1.60.3
Baseline Anxiety0.61.01.7-1.30.6-1.0
Tail length2.111.020.2-4.52.0-3.0
Length with tail4.017.728.5-5.31.6-4.7
Length without tail1.36.812.5-2.80.4-3.5
Times rat made contact with spout1.21.32.40.21.31.5
Lifetime Intake0.50.61.11.0-0.50.7
Liver weight, left1.01.72.8-1.50.1-1.7
Liver weight, right0.40.61.2-0.80.2-1.1
Locomotor activity0.00.00.10.3-0.10.0
Locomotor testing distance0.20.40.90.11.00.6
Locomotor testing rearing0.20.91.80.9-0.11.3
Locomotion in novel chamber0.60.81.11.0-1.0-0.6
Locomotion in novel chamber post-restriction0.41.12.10.9-1.4-0.5
Fecal boli incidents, locomotor time 10.10.30.50.10.70.5
Change in fecal boli incidents, locomotor task0.10.10.20.3-0.30.4
Time >=10cm from walls, locomotor time 10.50.60.90.4-0.9-0.9
Bouts of movement, locomotor time 10.70.91.41.2-0.70.9
Total resting periods, locomotor time 11.01.22.01.4-1.00.8
Rest time, locomotor task time 10.40.71.30.90.01.1
Distance moved, locomotor task time 10.10.30.3-0.4-0.6-0.6
Vertical activity count, locomotor time 10.00.10.1-0.1-0.4-0.3
Time >=10cm from walls, locomotor time 20.41.01.8-1.31.1-0.3
Bouts of movement, locomotor time 21.03.44.62.1-2.11.1
Total resting periods, locomotor time 20.83.24.62.2-1.81.2
Rest time, locomotor task time 21.01.62.81.30.51.7
Distance moved, locomotor task time 20.71.01.5-1.0-0.6-1.2
Vertical activity count, locomotor time 20.10.20.50.1-0.70.1
Light reinforcement 11.04.78.93.0-2.01.0
Light reinforcement 20.20.51.21.1-0.10.6
Bone: marrow area2.66.38.6-2.91.4-2.9
Bone: maximum diameter0.20.30.80.1-0.9-0.5
Bone: maximum force1.73.46.6-1.90.1-2.6
Bone: maximum moment1.12.14.3-1.40.1-2.1
Mean time between licks in bursts0.21.22.31.5-1.20.3
Mean num. licks in bursts0.00.00.1-0.1-0.0-0.3
Cd content in liver1.01.12.5-1.60.7-0.7
Co content in liver0.20.20.3-0.50.40.5
Cu content in liver0.60.71.2-1.10.9-0.3
Fe content in liver1.82.24.9-1.22.20.5
K content in liver0.60.51.41.20.20.5
Mg content in liver0.40.50.50.70.60.7
Mn content in liver0.80.91.60.90.51.3
Na content in liver0.40.41.20.01.10.3
Rb content in liver2.63.06.91.3-2.6-0.6
Se content in liver0.10.10.30.5-0.20.3
Sr content in liver0.20.20.30.5-0.40.5
Zn content in liver0.00.00.10.2-0.10.1
Bone: minimum diameter0.71.32.9-1.0-0.3-1.7
Time in familiar zone, hab. session 10.50.50.80.8-0.40.9
Time in novel zone, hab. session 12.52.84.0-2.01.9-0.9
Total zone transitions, hab. session 10.60.92.0-0.6-0.6-1.4
Total locomotion distance, hab. session 11.82.55.8-1.3-0.3-2.4
Locomotion velocity, hab. session 11.11.53.6-0.5-0.8-1.9
Time in familiar zone, hab. session 20.10.10.20.00.30.4
Time in novel zone, hab. session 20.00.00.10.10.00.3
Total zone transitions, hab. session 20.00.00.10.1-0.30.2
Total locomotion distance, hab. session 20.60.81.6-0.8-0.6-1.3
Locomotion velocity, hab. session 20.71.01.9-0.7-0.8-1.4
Novel to familiar place preference ratio0.91.21.7-1.31.2-0.6
Novelty place preference0.60.81.4-1.01.2-0.2
Time in novel zone, NPP test0.80.91.6-1.11.2-0.2
Total zone transitions, NPP test0.60.92.30.7-1.5-0.1
Total locomotion distance, NPP test0.30.41.0-0.5-0.1-1.0
Locomotion velocity, NPP test0.20.20.6-0.0-0.3-0.7
Intraocular pressure0.30.50.50.7-0.60.7
Delta distance traveled before/after self-admin0.60.61.50.5-1.20.3
Delta ambulatory time before/after self-admin0.50.81.90.7-1.40.3
Parametrial fat weight0.51.11.31.1-0.91.1
Pavlov. Cond. lever latency1.41.73.11.4-1.8-0.0
Pavlov. Cond. magazine entry latency2.22.84.6-2.11.7-1.0
Pavlov. Cond. change in total contacts1.11.22.3-1.50.9-0.6
Pavlov. Cond. index score1.72.13.5-1.71.9-0.1
Pavlov. Cond. latency score1.82.33.6-1.81.9-0.3
Pavlov. Cond. lever contacts1.21.42.7-1.31.60.2
Pavlov. Cond. magazine entry number2.53.25.32.3-1.90.9
Pavlov. Cond. intertrial magazine entries0.40.41.00.3-1.0-0.4
Pavlov. Cond. lever-magazine prob. diff.1.51.92.9-1.71.7-0.2
Pavlov. Cond. response bias1.82.33.4-1.81.8-0.4
Pavlov. Cond. lever latency0.30.50.70.7-0.80.5
Pavlov. Cond. magazine entry latency0.30.50.6-0.80.8-0.5
Pavlov. Cond. change in total contacts0.61.41.9-1.31.4-0.8
Pavlov. Cond. index score0.61.01.2-1.11.0-0.9
Pavlov. Cond. latency score0.61.01.2-1.10.9-1.0
Pavlov. Cond. lever contacts0.60.91.5-1.01.2-0.5
Pavlov. Cond. magazine entry number0.70.91.60.9-1.20.4
Pavlov. Cond. intertrial magazine entries0.51.11.41.2-1.10.8
Pavlov. Cond. lever-magazine prob. diff.0.40.60.7-0.80.8-0.7
Pavlov. Cond. response bias1.21.72.2-1.41.5-0.9
Time in closed arm before self-admin1.42.43.2-1.71.8-1.0
Time in closed arm after self-admin0.20.30.4-0.60.3-0.6
Time in open arm before self-admin2.93.57.31.7-2.70.4
Time in open arm after self-admin2.32.53.9-2.01.2-1.5
Bone: periosteal estimation1.43.46.1-2.00.3-2.5
Bone: periosteal perimeter0.51.11.8-1.1-0.3-1.3
Bone: post-yield work0.91.62.7-1.40.4-1.6
Progressive ratio test 1 active lever presses0.61.01.41.2-1.00.8
Progressive ratio test 1 breakpoint0.30.60.80.9-0.80.5
Progressive ratio test 1 inactive lever presses0.82.23.41.8-1.51.0
Progressive ratio test 2 active lever presses0.40.61.10.8-1.10.3
Progressive ratio test 2 breakpoint0.60.81.21.0-1.10.5
Progressive ratio test 2 inactive lever presses0.20.51.00.7-1.00.4
Incentive Sensitization - Responses0.00.10.2-0.2-0.5-0.3
Incentive Sensitization - Breakpoint0.10.10.4-0.0-0.6-0.1
Sum of active levers in priming session hrs 5-62.62.44.8-2.20.6-1.5
Progressive ratio0.61.63.90.3-2.0-0.9
Food seeking constrained by brief footshock0.50.60.9-0.1-1.0-1.0
Seeking ratio, punishment vs. effort0.10.30.7-0.40.8-0.2
Retroperitoneal fat weight0.31.33.20.8-1.8-0.4
Reaction time number correct0.41.62.21.5-1.40.7
Reaction time mean minus median0.63.65.9-2.12.4-0.8
Reaction time mean minus median AUC0.42.64.2-1.82.1-0.5
Reaction time num false alarms2.54.27.52.1-2.70.7
Reaction time num false alarms AUC1.73.86.22.2-2.50.6
Reaction time trials correct on left0.41.62.21.5-1.40.7
Reaction time trials on left0.41.52.11.4-1.40.6
Reaction time mean3.27.012.4-3.52.1-2.0
Reaction time mean AUC2.45.910.5-3.22.0-1.7
Median of all reaction times3.96.211.7-3.41.6-2.0
Reaction time omissions0.10.10.4-0.60.30.1
Reaction time false alarm rate1.01.42.41.3-1.60.3
Reaction time premature initiation rate0.00.00.1-0.00.20.2
Reaction time premature initiations0.10.30.50.7-0.50.5
Std. dev. reaction times2.37.511.1-3.33.0-1.6
Reaction time trials completed0.41.52.11.4-1.40.6
Reaction time trials AUC0.41.52.01.4-1.40.7
Run reversals in cocaine runway, females0.70.81.5-0.4-0.9-1.2
Run reversals in cocaine runway, males0.90.92.20.8-1.5-0.2
Latency to leave start box in cocaine runway2.43.35.92.4-1.21.6
Latency to leave start box in cocaine runway, F2.53.14.92.20.02.1
Latency to leave start box in cocaine runway, M2.12.04.61.2-2.2-0.4
Std. dev. time between licks in bursts2.75.07.92.8-2.11.7
Total sessions with >9 infusions1.21.53.11.8-1.10.3
Short access day 1 total inactive lever presses0.40.92.00.6-1.4-0.5
Short access day 10 total inactive lever presses0.00.10.10.4-0.10.2
Short access day 1 total infusions0.20.50.91.0-0.6-0.3
Short access day 10 total infusions1.42.33.31.7-0.81.8
Short access total infusions0.50.71.31.1-0.70.6
Short access day 1 locomotion0.50.81.21.1-1.1-0.3
Short access day 10 total locomotion0.10.50.80.8-0.90.2
Short access total locomotion1.11.73.01.4-1.7-0.0
One hour access (0.3 mA shock)0.30.40.70.5-0.90.4
Compulsive drug intake0.71.12.70.7-1.6-0.1
One hour access (shock baseline)0.00.10.10.00.30.4
Social response proportion0.40.51.0-1.00.3-0.7
Social responses0.20.20.6-0.1-0.8-0.4
Social time0.40.61.0-0.91.00.3
Soleus weight0.31.02.00.9-1.4-0.5
Bone: stiffness1.83.37.1-1.6-0.5-2.7
Tibialis anterior weight2.07.010.63.3-3.01.2
Time to tail flick, vehicle, before self-admin0.30.30.40.6-0.60.5
Time to tail flick, vehicle, after self-admin0.00.10.2-0.10.30.4
Time to tail flick, test, before self-admin1.82.04.91.0-2.2-0.3
Time to tail flick, test, after self-admin0.70.71.11.0-1.0-0.2
Delta time to tail flick, vehicle, before/after SA0.40.41.0-0.41.00.2
Delta time to tail flick, test, before/after SA0.91.23.3-0.11.80.4
Tibia length3.810.514.8-3.71.7-3.8
Ambulatory time before self-admin1.44.46.7-2.61.9-1.7
Ambulatory time after self-admin0.40.71.4-1.20.6-0.6
Bone: tissue strength0.10.10.3-0.20.5-0.1
Total heroin consumption0.91.12.1-0.91.50.4
Bone: trabecular number0.81.62.4-1.51.5-0.6
Bone: trabecular spacing0.60.81.80.3-1.4-0.7
Bone: trabecular thickness2.53.46.8-1.92.60.0
Bone: trabecular tissue density0.40.71.3-0.7-0.6-1.1
Water consumed over 24 hours0.30.50.90.80.11.0
Number of responses in last shaping day0.10.10.30.60.00.3