Hub : Genes

Nefh

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Nefh	0.06	0.04	4.9e-04	0.01	0.03	0.02	0.02	1.1e-02	4.2e-04	3.1e-03	6.7e-03
2	Liver	gene expression	Nefh	0.8	0.11	0.0e+00	0.47	0.49	0.48	0.48	6.5e-59	1.5e-61	1.9e-60	3.4e-59
3	Adipose	gene expression	Nefh	0.79	0.09	0.0e+00	0.59	0.6	0.59	0.59	8.9e-81	3.3e-82	1.5e-81	2.1e-80
4	OFC	gene expression	Nefh	0.2	0.14	9.5e-03	0.1	0.05	0.09	0.06	2.0e-03	2.0e-02	4.7e-03	1.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.7	1.1	1.4	0.8	1.1	1.1	-1.2
Area under the delay curve	0.2	0.2	0.7	0.8	-0.1	-0.4	0.1
BMI with tail	0.0	0.0	0.1	-0.1	-0.0	-0.0	0.3
BMI without tail	0.7	1.4	1.6	1.2	1.3	1.2	-1.1
Body weight	0.2	0.7	2.4	1.6	0.4	0.3	0.0
Weight adjusted by age	1.1	1.3	2.1	1.5	1.0	0.9	-1.0
Bone surface	0.1	0.2	0.3	0.5	0.6	0.4	-0.5
Bone volume	0.3	0.6	0.7	0.8	0.8	0.7	-0.7
Breakpoint value in progressive ratio session	0.1	0.1	0.3	0.5	0.0	-0.2	0.1
Number of licking bursts	0.4	0.4	1.6	1.3	0.3	0.2	-0.1
Context. condit. distance diff. score	0.2	0.3	0.8	-0.9	0.2	0.4	-0.3
Locomotion velocity, session 1	4.4	4.7	5.5	-2.0	-2.3	-2.2	2.1
Locomotion distance, session 1	0.7	0.9	1.2	0.5	1.0	1.1	-1.1
Locomotion velocity, session 2	3.1	3.6	4.0	-2.0	-1.9	-1.9	1.8
Locomotion distance, session 2	0.5	0.6	2.1	-1.4	-0.5	-0.4	0.3
Locomotion velocity, session 3	0.6	0.7	1.1	-0.2	0.9	1.0	-0.9
Locomotion distance, session 3	0.1	0.1	0.2	0.1	0.5	0.4	-0.4
Stereotopy head waving bouts, day 3	0.3	0.3	0.5	-0.1	0.6	0.7	-0.7
Stereotopy head waving duration, day 3	0.1	0.1	0.5	-0.7	-0.1	0.1	-0.1
Locomotion velocity, session 7	0.0	0.0	0.1	-0.1	-0.1	-0.2	0.3
Locomotion distance, session 7	0.3	0.4	0.8	-0.9	-0.5	-0.4	0.7
Stereotopy head waving bouts, day 7	0.0	0.0	0.0	-0.1	0.0	0.1	-0.1
Stereotopy head waving duration, day 7	0.5	0.6	0.7	0.7	0.8	0.8	-0.8
Locomotion velocity, session 8	1.3	1.5	3.5	-1.9	-1.0	-0.9	0.9
Locomotion distance, session 8	0.5	0.8	3.0	-1.7	-0.0	0.3	-0.2
Degree of sensitization distance	1.2	1.2	1.8	-1.3	-1.1	-0.9	1.0
Degree of sensitization stereotypy	0.0	0.1	0.2	0.4	0.0	0.0	-0.1
Conditioned locomotion	1.1	1.3	1.9	0.7	1.3	1.4	-1.2
Cocaine response after cond. corrected	0.2	0.2	0.7	0.9	0.1	-0.1	0.1
Cocaine response after cond. not corrected	0.6	0.7	2.0	1.4	0.6	0.5	-0.4
Cocaine response before conditioning	0.4	0.4	0.7	0.3	0.7	0.7	-0.8
Saline control response	0.4	0.6	1.3	-1.1	-0.5	-0.4	0.7
Bone: connectivity density	0.4	0.7	0.9	0.5	0.9	0.9	-0.9
Bone: cortical apparent density	0.1	0.1	0.5	0.7	0.1	0.1	-0.1
Bone: cortical area	0.3	0.5	1.6	1.3	0.4	0.2	-0.3
Bone: cortical porosity	0.5	0.5	0.7	0.8	0.7	0.6	-0.7
Bone: cortical porosity	0.2	0.2	0.3	0.3	0.4	0.4	-0.5
Bone: cortical thickness	1.2	2.0	3.6	1.9	1.3	1.1	-1.2
Bone: cortical thickness	1.9	2.2	2.7	1.2	1.6	1.6	-1.5
Bone: cortical tissue density	0.1	0.1	0.4	0.6	0.0	-0.1	-0.0
Condit. Reinf. active minus inactive responses	2.2	2.4	2.9	-1.3	-1.7	-1.7	1.5
Condit. Reinf. active-inactive response ratio	6.9	7.5	8.4	-2.7	-2.9	-2.8	2.6
Condit. Reinf. active responses	0.7	0.9	1.0	-0.8	-1.0	-1.0	1.0
Condit. Reinf. inactive responses	1.3	1.5	1.8	1.2	1.4	1.3	-1.1
Incentive salience index mean	0.8	0.9	1.2	-0.7	-1.0	-1.1	1.0
Condit. Reinf. lever presses	0.1	0.1	0.2	0.3	0.4	0.3	-0.3
Condit. Reinf. active minus inactive responses	0.1	0.2	0.3	-0.5	-0.4	-0.3	0.3
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.3	-0.4	-0.5	-0.5	0.5
Condit. Reinf. active responses	0.3	0.5	0.8	-0.9	-0.7	-0.5	0.5
Condit. Reinf. inactive responses	0.4	0.5	0.9	-1.0	-0.7	-0.5	0.5
Condit. Reinf. lever presses	0.0	0.1	0.1	-0.2	0.1	0.2	-0.3
Condit. Reinf. lever reinforcers received	0.2	0.3	0.6	-0.8	-0.6	-0.4	0.4
Conditioned reinforcement - actives	0.1	0.1	0.2	-0.4	-0.1	-0.3	0.4
Conditioned reinforcement - inactives	0.2	0.2	0.4	-0.2	-0.4	-0.5	0.7
Conditioned locomotion	0.2	0.2	0.4	0.5	0.6	0.4	-0.4
Patch foraging indifference point 0 sec	0.2	0.3	1.1	1.1	0.3	0.1	0.2
Patch foraging indifference point AUC	0.3	0.3	0.5	-0.4	-0.5	-0.5	0.7
Delay disc. indifference point, 0s delay	0.2	0.2	0.7	0.8	0.3	0.2	-0.4
Delay disc. indifference point, 16s delay	1.2	1.2	2.0	-0.4	-1.2	-1.4	1.1
Delay disc. indifference point, 2s delay	2.0	2.2	3.5	1.9	1.4	1.2	-1.4
Delay disc. indifference point, 24s delay	0.5	0.5	0.8	-0.3	-0.8	-0.9	0.7
Delay disc. indifference point, 4s delay	0.9	0.9	2.5	1.6	0.7	0.5	-0.7
Delay disc. indifference point, 8s delay	0.2	0.2	0.3	0.1	-0.5	-0.6	0.4
Indifference point function ln k	0.8	1.2	1.5	0.9	1.1	1.1	-1.2
Indifference point function log k	0.8	1.2	1.5	0.9	1.1	1.1	-1.2
Patch foraging total patch changes 0 sec	0.1	0.2	0.7	0.8	0.1	-0.1	0.4
Patch foraging total patch changes 12 sec	0.1	0.2	0.3	0.5	-0.1	-0.2	0.6
Patch foraging total patch changes 18 sec	2.1	2.6	3.8	-0.9	-1.7	-1.8	2.0
Patch foraging total patch changes 24 sec	1.2	1.5	2.1	-1.4	-1.1	-1.0	1.3
Patch foraging total patch changes 6 sec	0.1	0.2	0.4	0.3	-0.3	-0.4	0.6
Patch foraging time to switch 0 sec	0.0	0.0	0.0	-0.0	0.1	0.1	-0.2
Patch foraging water rate 0 sec	0.2	0.4	0.9	0.0	-0.5	-0.7	0.9
Patch foraging water rate 12 sec	0.0	0.0	0.1	0.0	0.3	0.2	-0.2
Patch foraging water rate 18 sec	2.5	3.3	3.5	1.9	1.9	1.9	-1.7
Patch foraging water rate 24 sec	0.7	0.9	1.1	-0.9	-1.0	-1.0	0.9
Patch foraging water rate 6 sec	0.2	0.3	0.6	0.8	0.6	0.5	-0.4
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.1	-0.3	-0.2	-0.2	0.1
Distance traveled before self-admin	1.4	1.4	2.2	1.5	1.1	1.1	-1.1
Distance traveled after self-admin	1.2	1.4	1.7	1.3	1.2	1.1	-1.1
Extensor digitorum longus weight	0.3	1.2	4.5	2.1	0.6	0.2	-0.3
Bone: elastic displacement	1.0	1.2	1.5	0.8	1.2	1.2	-1.0
Bone: elastic work	1.9	2.4	2.7	1.6	1.6	1.5	-1.4
Bone: endosteal estimation	0.0	0.0	0.1	0.3	0.0	-0.0	-0.0
Bone: endosteal perimeter	0.1	0.1	0.2	0.4	-0.4	-0.5	0.3
Epididymis fat weight	0.8	2.0	2.9	1.0	1.5	1.7	-1.3
Delta time in closed arm before/after self-admin	0.5	0.5	0.9	-0.4	0.5	0.8	-0.9
Delta time in open arm before/after self-admin	0.8	0.8	1.4	0.6	-0.7	-1.0	1.2
Diff in mean of infusions in LGA sessions	0.1	0.1	0.2	0.4	0.3	0.4	-0.2
Delay discount exponential model param	0.2	0.2	0.8	-0.9	0.0	0.3	-0.0
Extinction: sum of active levers before priming	0.7	0.7	0.8	-0.7	-0.8	-0.8	0.9
Active lever presses in extinction session 6	0.6	0.5	0.8	0.9	0.7	0.6	-0.6
Bone: final force	0.1	0.1	0.2	0.5	0.3	0.2	-0.3
Bone: final moment	0.2	0.3	0.5	0.7	0.4	0.3	-0.4
Food consumed during 24 hour testing period	1.2	1.5	2.1	-0.8	-1.3	-1.5	1.2
Glucose	19.1	28.8	37.2	-3.2	-5.7	-6.1	5.9
Heart weight	0.9	1.3	2.4	-1.5	-1.1	-0.9	0.9
Delay discount hyperbolic model param	0.2	0.2	1.0	-1.0	-0.1	0.2	0.1
Intermittent access intake day 1-15 change	1.3	1.3	1.6	-1.1	-1.1	-1.1	1.3
Intermittent access intake escalation	0.9	0.9	1.1	-1.0	-0.9	-0.9	1.0
Intermittent access intake escalation 2	0.4	0.4	0.5	-0.6	-0.7	-0.7	0.7
Intermitt. access day 1 inactive lever presses	0.6	0.6	1.0	-1.0	-0.8	-0.5	0.7
Intermitt. access day 15 inactive lever presses	3.0	3.3	4.2	-1.5	-1.8	-1.8	2.1
Intermitt. access escalation Index	0.8	0.7	1.1	-0.7	-0.8	-0.8	1.1
Intermittent access day 1 total infusions	0.2	0.3	0.3	0.5	0.6	0.4	-0.5
Intermittent access day 15 total infusions	0.1	0.1	0.2	-0.1	-0.2	-0.4	0.4
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.1	-0.1	-0.1	-0.3	0.3
Intermittent access total infusions	0.1	0.1	0.1	0.4	0.4	0.2	-0.3
Intermittent access day 1 locomotion	0.1	0.1	0.2	0.0	0.4	0.4	-0.5
Intermittent access day 15 total locomotion	0.4	0.4	0.6	-0.4	-0.6	-0.8	0.8
Intermittent access total locomotion	0.0	0.0	0.1	0.0	-0.1	-0.3	0.2
Intermittent access standard deviation	0.1	0.1	0.2	-0.4	0.2	0.3	-0.3
Left kidney weight	0.4	1.0	1.2	1.0	0.9	1.1	-1.0
Right kidney weight	1.1	3.1	4.0	1.4	1.7	2.0	-1.8
Cocaine induced anxiety	0.1	0.1	0.2	0.2	-0.2	-0.5	0.4
Post-drug Anxiety	0.4	0.5	0.7	-0.4	-0.6	-0.8	0.8
Baseline Anxiety	0.9	1.0	1.1	-1.1	-0.9	-0.9	1.0
Tail length	1.6	4.8	9.3	3.0	1.9	1.7	-1.8
Length with tail	0.4	1.4	4.8	2.2	0.7	0.5	-0.5
Length without tail	0.4	0.9	1.3	-0.1	-1.0	-1.1	1.1
Times rat made contact with spout	3.4	3.9	4.2	-2.0	-2.0	-2.0	1.9
Lifetime Intake	0.4	0.4	0.5	0.7	0.7	0.5	-0.6
Liver weight, left	2.0	3.2	4.0	1.5	1.8	2.0	-1.9
Liver weight, right	1.6	2.7	3.7	0.9	1.6	1.9	-1.9
Locomotor activity	1.0	1.6	2.2	-0.5	-1.4	-1.4	1.5
Locomotor testing distance	0.8	1.3	2.4	1.5	1.1	1.0	-0.8
Locomotor testing rearing	0.1	0.2	0.3	0.6	-0.2	-0.4	0.6
Locomotion in novel chamber	0.7	0.9	1.4	-0.1	1.0	1.2	-1.2
Locomotion in novel chamber post-restriction	1.9	2.3	5.0	-2.2	-1.4	-1.1	1.0
Fecal boli incidents, locomotor time 1	0.1	0.1	0.3	-0.5	-0.2	-0.2	0.3
Change in fecal boli incidents, locomotor task	1.3	1.2	1.4	-1.0	-1.2	-1.1	1.0
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	-0.2	-0.2	-0.2	0.3
Bouts of movement, locomotor time 1	2.1	2.3	2.9	-1.2	-1.6	-1.7	1.5
Total resting periods, locomotor time 1	2.8	3.0	3.5	-1.6	-1.8	-1.9	1.7
Rest time, locomotor task time 1	0.8	0.9	1.0	-1.0	-1.0	-1.0	0.8
Distance moved, locomotor task time 1	1.0	1.1	2.0	1.4	1.0	1.0	-0.7
Vertical activity count, locomotor time 1	0.4	0.4	0.8	0.9	0.6	0.6	-0.4
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.2	-0.4	-0.4	-0.4	0.5
Bouts of movement, locomotor time 2	0.0	0.0	0.1	0.1	0.2	0.2	-0.2
Total resting periods, locomotor time 2	0.0	0.0	0.0	-0.1	0.1	0.0	-0.1
Rest time, locomotor task time 2	0.1	0.1	0.2	-0.5	-0.2	-0.2	0.2
Distance moved, locomotor task time 2	0.0	0.0	0.1	-0.2	-0.2	-0.2	0.3
Vertical activity count, locomotor time 2	0.0	0.0	0.0	0.2	0.1	0.0	0.0
Light reinforcement 1	0.7	1.2	1.4	1.1	1.2	1.1	-1.0
Light reinforcement 2	0.9	1.2	1.8	1.3	1.1	1.0	-1.0
Bone: marrow area	0.0	0.0	0.0	0.2	-0.0	-0.1	0.0
Bone: maximum diameter	0.8	1.4	2.4	0.1	-1.3	-1.5	1.3
Bone: maximum force	0.2	0.4	0.7	0.8	0.6	0.5	-0.6
Bone: maximum moment	0.4	0.8	1.2	1.1	0.8	0.7	-0.8
Mean time between licks in bursts	2.9	4.1	5.2	-1.6	-2.3	-2.3	1.9
Mean num. licks in bursts	2.7	3.2	6.1	-2.5	-1.6	-1.5	1.3
Cd content in liver	0.3	0.3	0.4	0.3	0.6	0.6	-0.5
Co content in liver	0.1	0.2	0.3	0.2	0.5	0.5	-0.4
Cu content in liver	0.2	0.2	0.5	-0.0	-0.4	-0.4	0.7
Fe content in liver	4.2	5.0	5.7	-2.4	-2.3	-2.2	2.1
K content in liver	3.5	3.4	4.0	2.0	2.0	1.8	-1.6
Mg content in liver	0.5	0.5	0.8	0.7	0.9	0.8	-0.5
Mn content in liver	3.7	4.2	5.2	1.9	2.3	2.1	-1.9
Na content in liver	1.2	1.3	1.9	-0.3	-1.1	-1.4	1.3
Rb content in liver	0.8	1.0	2.4	1.6	0.9	0.7	-0.4
Se content in liver	0.5	0.7	1.2	1.1	0.8	0.6	-0.6
Sr content in liver	1.6	1.5	2.1	-0.6	-1.4	-1.4	1.3
Zn content in liver	0.3	0.3	0.4	0.6	0.6	0.5	-0.3
Bone: minimum diameter	0.2	0.4	0.4	0.5	0.6	0.6	-0.6
Time in familiar zone, hab. session 1	0.1	0.1	0.1	0.0	0.3	0.3	-0.3
Time in novel zone, hab. session 1	0.3	0.3	0.7	0.8	0.4	0.3	-0.4
Total zone transitions, hab. session 1	0.0	0.0	0.0	-0.2	-0.2	-0.1	0.2
Total locomotion distance, hab. session 1	0.1	0.2	0.2	0.5	0.5	0.4	-0.4
Locomotion velocity, hab. session 1	0.0	0.0	0.1	-0.3	-0.2	-0.2	0.2
Time in familiar zone, hab. session 2	0.2	0.2	0.5	-0.7	-0.4	-0.2	0.2
Time in novel zone, hab. session 2	0.3	0.3	0.8	0.9	0.5	0.3	-0.2
Total zone transitions, hab. session 2	0.0	0.0	0.0	0.2	-0.1	-0.1	0.1
Total locomotion distance, hab. session 2	0.2	0.2	0.3	-0.3	-0.5	-0.6	0.5
Locomotion velocity, hab. session 2	0.1	0.2	0.3	-0.0	-0.4	-0.5	0.4
Novel to familiar place preference ratio	1.3	1.4	1.8	-0.7	-1.3	-1.3	1.3
Novelty place preference	1.4	1.4	1.9	-0.7	-1.3	-1.4	1.3
Time in novel zone, NPP test	1.2	1.2	1.6	-0.6	-1.2	-1.3	1.2
Total zone transitions, NPP test	0.8	1.1	1.4	0.5	1.2	1.2	-1.2
Total locomotion distance, NPP test	0.2	0.2	0.3	0.3	0.5	0.6	-0.5
Locomotion velocity, NPP test	0.1	0.1	0.2	0.3	0.3	0.4	-0.4
Intraocular pressure	0.9	1.3	1.6	-0.9	-1.3	-1.3	1.1
Delta distance traveled before/after self-admin	0.1	0.1	0.3	-0.6	-0.3	-0.2	0.3
Delta ambulatory time before/after self-admin	0.1	0.1	0.4	-0.6	-0.3	-0.1	0.1
Parametrial fat weight	2.9	5.6	7.2	-1.4	-2.5	-2.6	2.7
Pavlov. Cond. lever latency	0.8	1.0	1.3	-0.5	-1.1	-1.1	1.1
Pavlov. Cond. magazine entry latency	0.4	0.5	0.8	-0.4	0.8	0.9	-0.8
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	0.1	0.1	-0.1	0.1
Pavlov. Cond. index score	0.6	0.8	1.1	-0.3	1.0	1.1	-1.0
Pavlov. Cond. latency score	0.5	0.7	1.0	-0.1	0.9	1.0	-0.9
Pavlov. Cond. lever contacts	0.5	0.6	0.8	-0.1	0.8	0.9	-0.9
Pavlov. Cond. magazine entry number	0.3	0.4	0.7	0.8	-0.5	-0.6	0.5
Pavlov. Cond. intertrial magazine entries	1.1	1.3	2.4	1.6	1.0	1.0	-0.9
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	1.3	-0.3	1.0	1.1	-1.1
Pavlov. Cond. response bias	0.7	0.8	1.1	-0.2	1.1	1.1	-1.0
Pavlov. Cond. lever latency	1.7	2.2	5.6	2.4	1.3	1.0	-0.8
Pavlov. Cond. magazine entry latency	0.1	0.1	0.1	0.1	0.4	0.3	-0.3
Pavlov. Cond. change in total contacts	0.3	0.4	0.7	-0.8	-0.6	-0.6	0.5
Pavlov. Cond. index score	0.3	0.4	1.2	-1.1	-0.4	-0.3	0.2
Pavlov. Cond. latency score	0.2	0.2	0.9	-0.9	-0.2	-0.1	0.0
Pavlov. Cond. lever contacts	1.6	2.2	4.8	-2.2	-1.4	-1.1	0.9
Pavlov. Cond. magazine entry number	0.2	0.2	0.3	0.6	0.4	0.4	-0.4
Pavlov. Cond. intertrial magazine entries	0.0	0.1	0.1	-0.2	-0.3	-0.2	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.8	-0.9	-0.2	-0.1	-0.0
Pavlov. Cond. response bias	1.1	1.6	3.0	-1.7	-1.2	-1.0	0.9
Time in closed arm before self-admin	0.4	0.5	1.0	1.0	0.6	0.5	-0.6
Time in closed arm after self-admin	0.4	0.4	0.6	0.2	0.6	0.8	-0.7
Time in open arm before self-admin	0.2	0.2	0.8	-0.9	0.0	0.2	-0.1
Time in open arm after self-admin	1.5	1.7	2.1	-1.2	-1.2	-1.4	1.4
Bone: periosteal estimation	0.1	0.2	0.9	0.9	0.3	0.1	-0.2
Bone: periosteal perimeter	0.1	0.2	0.7	0.8	-0.1	-0.3	0.1
Bone: post-yield work	0.0	0.0	0.1	0.3	0.1	0.1	-0.1
Progressive ratio test 1 active lever presses	0.1	0.1	0.1	-0.3	-0.2	-0.4	0.4
Progressive ratio test 1 breakpoint	0.0	0.0	0.1	-0.2	-0.0	-0.1	0.1
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.2	0.4	-0.3	-0.5	0.4
Progressive ratio test 2 active lever presses	0.0	0.0	0.0	0.1	0.2	0.0	-0.1
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	-0.1	0.1	-0.1	0.1
Progressive ratio test 2 inactive lever presses	0.8	1.0	1.4	-0.7	-0.9	-1.1	1.2
Incentive Sensitization - Responses	0.2	0.2	0.2	-0.3	-0.4	-0.5	0.4
Incentive Sensitization - Breakpoint	0.2	0.2	0.2	-0.4	-0.4	-0.4	0.4
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	0.2	-0.1	-0.0	-0.3
Progressive ratio	0.4	0.4	0.6	0.6	0.7	0.5	-0.8
Food seeking constrained by brief footshock	3.0	3.7	6.3	2.5	1.7	1.5	-1.8
Seeking ratio, punishment vs. effort	0.2	0.2	0.7	0.8	0.3	0.3	-0.2
Retroperitoneal fat weight	0.2	0.7	0.9	-0.8	-0.8	-0.7	1.0
Reaction time number correct	0.3	0.4	0.6	-0.7	-0.6	-0.6	0.6
Reaction time mean minus median	1.7	2.2	3.4	-1.8	-1.5	-1.2	1.4
Reaction time mean minus median AUC	0.3	0.4	0.9	-0.9	-0.5	-0.3	0.5
Reaction time num false alarms	1.0	1.4	1.8	1.1	1.3	1.2	-1.0
Reaction time num false alarms AUC	1.9	2.6	3.1	1.5	1.8	1.6	-1.4
Reaction time trials correct on left	0.3	0.4	0.6	-0.7	-0.6	-0.6	0.6
Reaction time trials on left	0.3	0.4	0.6	-0.7	-0.6	-0.6	0.6
Reaction time mean	0.5	0.6	0.9	-1.0	-0.9	-0.6	0.6
Reaction time mean AUC	0.2	0.3	0.6	-0.8	-0.6	-0.3	0.4
Median of all reaction times	0.2	0.3	0.5	-0.6	-0.7	-0.5	0.4
Reaction time omissions	0.1	0.1	0.3	-0.5	0.1	0.3	-0.4
Reaction time false alarm rate	2.4	3.4	3.8	1.9	2.0	1.9	-1.7
Reaction time premature initiation rate	1.2	1.6	2.5	0.4	1.3	1.6	-1.4
Reaction time premature initiations	0.5	0.7	1.1	-0.0	0.8	1.0	-0.9
Std. dev. reaction times	1.4	1.9	2.8	-1.7	-1.4	-1.1	1.3
Reaction time trials completed	0.3	0.4	0.6	-0.7	-0.6	-0.6	0.6
Reaction time trials AUC	0.2	0.3	0.4	-0.6	-0.5	-0.5	0.5
Run reversals in cocaine runway, females	0.1	0.1	0.3	-0.6	-0.2	-0.1	0.2
Run reversals in cocaine runway, males	0.1	0.1	0.3	0.5	0.1	0.0	0.1
Latency to leave start box in cocaine runway	0.5	0.5	0.6	0.8	0.8	0.7	-0.6
Latency to leave start box in cocaine runway, F	1.0	1.1	1.6	1.3	0.9	0.9	-1.1
Latency to leave start box in cocaine runway, M	0.1	0.1	0.3	-0.4	-0.0	-0.0	0.6
Std. dev. time between licks in bursts	0.2	0.3	0.3	-0.4	-0.5	-0.5	0.6
Total sessions with >9 infusions	0.9	1.0	1.3	0.8	1.1	1.0	-1.1
Short access day 1 total inactive lever presses	0.9	1.0	2.9	1.7	0.8	0.5	-0.5
Short access day 10 total inactive lever presses	0.0	0.0	0.0	-0.2	-0.2	0.0	0.0
Short access day 1 total infusions	1.4	1.5	1.8	1.0	1.3	1.3	-1.3
Short access day 10 total infusions	0.8	0.9	1.2	0.9	1.0	0.9	-1.1
Short access total infusions	1.9	2.2	2.8	1.3	1.5	1.4	-1.7
Short access day 1 locomotion	3.6	3.9	5.4	1.4	2.0	2.0	-2.3
Short access day 10 total locomotion	0.8	0.9	1.5	0.6	0.9	1.0	-1.2
Short access total locomotion	2.5	2.6	4.0	0.9	1.6	1.7	-2.0
One hour access (0.3 mA shock)	0.1	0.1	0.2	0.2	0.5	0.3	-0.3
Compulsive drug intake	0.2	0.2	0.4	-0.4	0.3	0.6	-0.6
One hour access (shock baseline)	0.0	0.1	0.1	0.2	0.0	-0.3	0.3
Social response proportion	3.6	3.9	4.8	-1.4	-2.1	-2.2	2.1
Social responses	2.3	2.9	3.7	-1.1	-1.8	-1.9	1.9
Social time	1.3	1.7	2.1	-1.1	-1.5	-1.4	1.3
Soleus weight	0.7	2.0	4.5	2.1	1.2	1.0	-1.0
Bone: stiffness	0.0	0.0	0.0	-0.1	-0.1	-0.1	-0.0
Tibialis anterior weight	0.1	0.3	0.4	0.6	-0.5	-0.6	0.6
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.1	0.3	0.3	0.3	-0.3
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.3	0.5	0.4	0.4	-0.6
Time to tail flick, test, before self-admin	0.0	0.0	0.1	-0.1	0.2	0.3	0.1
Time to tail flick, test, after self-admin	0.8	0.8	2.4	1.5	0.7	0.5	-0.2
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.0	0.2	0.0	0.0	-0.2
Delta time to tail flick, test, before/after SA	0.1	0.1	0.2	0.4	-0.2	-0.3	0.3
Tibia length	1.1	3.0	3.3	1.8	1.6	1.7	-1.8
Ambulatory time before self-admin	2.9	3.1	4.2	2.1	1.7	1.6	-1.6
Ambulatory time after self-admin	1.1	1.2	1.5	1.2	1.0	1.0	-1.1
Bone: tissue strength	0.2	0.2	0.3	-0.2	-0.5	-0.5	0.5
Total heroin consumption	0.0	0.0	0.1	0.2	0.1	-0.0	-0.0
Bone: trabecular number	0.8	1.3	1.4	1.0	1.2	1.2	-1.2
Bone: trabecular spacing	0.4	0.5	0.8	-0.2	-0.8	-0.9	0.8
Bone: trabecular thickness	1.4	1.7	2.3	0.7	1.3	1.5	-1.5
Bone: trabecular tissue density	1.6	2.3	2.6	-1.5	-1.5	-1.4	1.6
Water consumed over 24 hours	1.2	1.5	1.9	-0.8	-1.3	-1.4	1.3
Number of responses in last shaping day	0.8	0.9	1.3	0.5	1.0	0.9	-1.1