Hub : Genes

Nedd1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	mRNA stability	Nedd1	0.07	0.04	7.1e-09	0.06	0.07	0.06	0.06	1.9e-07	4.1e-08	8.2e-07	1.3e-07
2	Liver	mRNA stability	Nedd1	0.05	0.03	7.2e-06	0.01	0.04	0.03	0.02	7.0e-03	7.0e-05	2.6e-04	1.8e-03
3	Liver	gene expression	Nedd1	0.17	0.07	0.0e+00	0.2	0.22	0.22	0.21	2.8e-22	5.1e-24	8.4e-24	3.3e-23
4	PL	gene expression	Nedd1	0.09	0.04	1.2e-08	0.07	0.07	0.06	0.07	5.8e-08	5.0e-08	3.0e-07	9.7e-08
5	Brain	mRNA stability	Nedd1	0.07	0.04	6.6e-06	0.04	0.05	0.04	0.04	1.5e-04	3.7e-05	1.3e-04	2.0e-04
6	IC	gene expression	Nedd1	0.18	0.09	3.8e-06	0.06	0.12	0.1	0.13	1.1e-03	1.3e-05	5.3e-05	3.1e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.6	1.0	1.9	-0.7	-0.8	0.0	1.4	-1.2	1.3
Area under the delay curve	0.9	1.1	1.5	1.0	1.1	0.8	-1.2	1.2	-0.9
BMI with tail	1.9	6.4	8.2	-2.7	-2.9	-2.0	2.5	-2.7	2.3
BMI without tail	1.8	5.6	8.4	-2.9	-2.8	-2.5	2.0	-2.2	1.6
Body weight	3.8	16.6	29.2	-5.4	-4.9	-5.2	2.5	-3.3	1.6
Weight adjusted by age	1.3	1.9	3.6	-1.8	-1.7	-1.9	0.7	-1.1	0.3
Bone surface	0.2	0.4	1.0	-0.0	-0.1	0.4	0.9	-0.5	1.0
Bone volume	0.8	1.4	2.8	-0.8	-0.8	0.0	1.7	-1.3	1.7
Breakpoint value in progressive ratio session	0.3	0.3	0.8	0.2	-0.1	0.4	0.9	-0.5	0.8
Number of licking bursts	0.4	0.6	0.9	-0.8	-0.9	-0.6	0.7	-1.0	0.8
Context. condit. distance diff. score	0.5	0.6	1.0	-1.0	-0.9	-1.0	0.5	-0.6	0.3
Locomotion velocity, session 1	1.6	1.7	2.0	1.4	1.4	1.0	-1.4	1.4	-1.1
Locomotion distance, session 1	0.3	0.4	0.5	0.7	0.7	0.7	-0.7	0.4	-0.6
Locomotion velocity, session 2	0.3	0.4	1.1	-0.0	0.2	-0.3	-1.0	0.6	-0.9
Locomotion distance, session 2	0.0	0.1	0.1	0.1	-0.1	0.3	-0.3	-0.3	0.2
Locomotion velocity, session 3	0.2	0.3	0.5	-0.7	-0.6	-0.7	0.2	-0.4	0.1
Locomotion distance, session 3	1.6	1.7	3.1	-1.7	-1.6	-1.8	0.5	-1.2	0.4
Stereotopy head waving bouts, day 3	0.7	0.8	2.2	1.2	0.8	1.5	0.4	0.0	0.8
Stereotopy head waving duration, day 3	0.9	1.1	2.6	1.4	1.3	1.6	-0.2	0.7	0.2
Locomotion velocity, session 7	0.3	0.3	0.8	-0.4	-0.3	-0.8	-0.6	0.2	-0.9
Locomotion distance, session 7	0.5	0.7	2.0	-0.1	0.0	-0.7	-1.1	0.5	-1.4
Stereotopy head waving bouts, day 7	0.5	0.6	1.2	-0.1	0.3	-0.6	-0.9	0.9	-1.1
Stereotopy head waving duration, day 7	0.2	0.2	0.5	-0.0	0.3	-0.4	-0.6	0.7	-0.6
Locomotion velocity, session 8	0.4	0.5	1.4	-0.1	0.1	-0.4	-1.2	0.6	-1.1
Locomotion distance, session 8	0.9	1.3	2.1	-1.4	-1.4	-1.2	0.5	-1.3	0.6
Degree of sensitization distance	1.9	2.0	2.6	1.3	1.5	0.9	-1.5	1.5	-1.6
Degree of sensitization stereotypy	0.6	0.6	1.4	-0.2	0.1	-0.8	-0.9	0.9	-1.2
Conditioned locomotion	0.7	0.8	1.9	-0.7	-0.7	-0.5	1.4	-0.8	1.1
Cocaine response after cond. corrected	1.8	2.2	5.5	0.2	0.6	-0.6	-2.2	1.4	-2.3
Cocaine response after cond. not corrected	1.7	2.0	5.0	0.5	0.7	-0.2	-2.1	1.3	-2.2
Cocaine response before conditioning	0.4	0.5	1.0	0.6	0.3	1.0	0.9	-0.4	0.9
Saline control response	0.2	0.2	0.3	0.5	0.5	0.3	-0.5	0.4	-0.5
Bone: connectivity density	0.1	0.2	0.4	0.2	0.4	0.2	-0.5	0.5	-0.6
Bone: cortical apparent density	2.0	2.7	4.6	-2.1	-1.9	-2.0	1.2	-1.4	0.7
Bone: cortical area	1.4	2.2	3.1	-1.7	-1.6	-1.4	1.5	-1.4	1.1
Bone: cortical porosity	0.3	0.3	0.6	0.6	0.8	0.6	-0.4	0.7	-0.3
Bone: cortical porosity	0.4	0.4	0.9	0.8	0.8	1.0	-0.1	0.5	0.0
Bone: cortical thickness	1.0	1.7	2.8	-1.7	-1.4	-1.4	1.3	-1.1	0.9
Bone: cortical thickness	0.1	0.1	0.4	-0.2	0.1	-0.3	-0.3	0.4	-0.6
Bone: cortical tissue density	1.9	2.6	4.5	-2.1	-1.9	-1.9	1.2	-1.4	0.6
Condit. Reinf. active minus inactive responses	2.2	2.5	7.0	1.8	1.5	2.6	0.5	0.3	1.3
Condit. Reinf. active-inactive response ratio	2.0	2.2	5.6	1.5	1.2	2.4	0.9	0.0	1.6
Condit. Reinf. active responses	4.2	5.2	11.9	3.0	2.7	3.5	-0.7	1.4	0.2
Condit. Reinf. inactive responses	2.5	3.1	4.1	2.0	1.9	1.7	-1.8	1.7	-1.4
Incentive salience index mean	1.7	2.1	6.1	1.7	1.4	2.5	0.2	0.1	1.2
Condit. Reinf. lever presses	0.3	0.4	1.1	0.5	0.3	1.1	0.1	-0.4	0.8
Condit. Reinf. active minus inactive responses	0.5	0.6	1.6	-0.4	-0.5	-0.0	1.3	-0.9	1.1
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	-0.2	-0.2	-0.1	0.2	-0.3	0.1
Condit. Reinf. active responses	1.3	1.8	3.7	-0.8	-1.0	-0.2	1.9	-1.5	1.8
Condit. Reinf. inactive responses	0.7	0.9	2.0	-0.5	-0.7	-0.2	1.4	-1.0	1.3
Condit. Reinf. lever presses	0.7	0.9	1.9	-1.2	-1.1	-1.4	0.7	-0.6	0.4
Condit. Reinf. lever reinforcers received	1.2	1.7	3.3	-0.9	-1.0	-0.3	1.8	-1.4	1.7
Conditioned reinforcement - actives	0.3	0.5	1.8	0.9	0.7	1.3	0.0	-0.1	-0.0
Conditioned reinforcement - inactives	0.9	1.4	1.9	1.0	1.2	0.8	-1.4	1.2	-1.3
Conditioned locomotion	0.0	0.0	0.1	-0.1	-0.1	-0.0	-0.0	-0.2	-0.2
Patch foraging indifference point 0 sec	0.1	0.2	0.5	0.3	0.6	0.2	-0.2	0.7	-0.1
Patch foraging indifference point AUC	0.2	0.2	0.5	-0.2	0.0	-0.4	-0.7	0.4	-0.7
Delay disc. indifference point, 0s delay	0.9	1.0	1.6	1.3	1.1	1.0	-0.9	1.0	-0.6
Delay disc. indifference point, 16s delay	0.1	0.1	0.1	0.3	0.1	0.4	-0.2	-0.1	0.2
Delay disc. indifference point, 2s delay	1.0	1.2	1.7	1.0	1.0	0.4	-1.3	1.2	-1.2
Delay disc. indifference point, 24s delay	0.2	0.2	0.6	0.3	0.3	0.8	-0.1	-0.0	0.5
Delay disc. indifference point, 4s delay	2.2	2.3	3.2	1.5	1.7	1.1	-1.6	1.8	-1.3
Delay disc. indifference point, 8s delay	0.3	0.3	0.6	0.4	0.6	0.3	-0.8	0.7	-0.6
Indifference point function ln k	0.0	0.0	0.1	0.2	0.3	0.2	-0.0	0.2	-0.1
Indifference point function log k	0.0	0.0	0.1	0.2	0.3	0.2	-0.0	0.2	-0.1
Patch foraging total patch changes 0 sec	0.0	0.1	0.3	0.1	0.4	-0.0	-0.2	0.6	-0.2
Patch foraging total patch changes 12 sec	0.3	0.3	1.0	-0.9	-0.6	-1.0	0.1	0.0	-0.0
Patch foraging total patch changes 18 sec	0.1	0.2	0.3	-0.1	0.1	-0.5	-0.5	0.6	-0.5
Patch foraging total patch changes 24 sec	0.3	0.4	1.0	0.4	0.6	0.0	-0.8	1.0	-0.7
Patch foraging total patch changes 6 sec	0.3	0.5	0.9	0.8	0.9	0.9	-0.1	0.7	0.3
Patch foraging time to switch 0 sec	0.6	1.3	3.0	-0.4	-0.6	0.3	1.7	-1.2	1.7
Patch foraging water rate 0 sec	0.1	0.3	0.5	-0.6	-0.7	-0.6	0.2	-0.7	0.2
Patch foraging water rate 12 sec	0.0	0.0	0.2	-0.0	-0.0	-0.2	-0.4	0.2	-0.0
Patch foraging water rate 18 sec	0.4	0.7	1.2	-0.5	-0.8	-0.3	0.8	-1.1	1.1
Patch foraging water rate 24 sec	1.7	2.4	3.6	-1.8	-1.9	-1.7	1.1	-1.7	0.8
Patch foraging water rate 6 sec	3.5	5.1	7.9	-2.6	-2.8	-2.5	1.5	-2.4	1.2
Seeking ratio, delayed vs. immediate footshock	0.5	0.6	1.0	0.6	0.8	0.4	-1.0	0.9	-0.9
Distance traveled before self-admin	2.2	2.8	4.8	-2.1	-2.1	-2.2	1.0	-1.5	0.5
Distance traveled after self-admin	0.4	0.5	1.2	-0.9	-0.8	-1.1	-0.4	-0.4	-0.4
Extensor digitorum longus weight	0.9	3.7	9.1	-0.6	-1.0	0.6	2.7	-2.0	3.0
Bone: elastic displacement	1.3	1.5	2.4	1.6	1.5	1.5	-0.7	1.1	-0.8
Bone: elastic work	1.1	1.4	2.7	1.5	1.5	1.6	-0.4	1.0	-0.5
Bone: endosteal estimation	0.3	0.7	1.3	-0.1	-0.5	0.4	1.0	-1.1	1.1
Bone: endosteal perimeter	0.6	1.3	1.9	-1.3	-1.4	-0.9	1.0	-1.4	0.8
Epididymis fat weight	0.9	3.1	5.6	-2.2	-2.1	-2.4	1.0	-1.3	1.0
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	-0.1	-0.1	0.3	0.2	-0.3	0.4
Delta time in open arm before/after self-admin	1.2	1.1	2.7	0.5	0.7	-0.2	-1.4	1.2	-1.6
Diff in mean of infusions in LGA sessions	0.7	0.9	1.9	1.3	1.1	1.4	0.2	0.5	0.4
Delay discount exponential model param	1.0	1.2	1.8	-0.9	-1.1	-0.6	1.4	-1.2	1.1
Extinction: sum of active levers before priming	1.4	1.6	2.6	1.6	1.4	1.5	-1.0	1.0	-0.8
Active lever presses in extinction session 6	0.3	0.3	1.2	0.7	0.5	1.1	0.2	-0.0	0.3
Bone: final force	0.4	0.6	1.4	-0.5	-0.6	-0.0	1.2	-0.9	1.0
Bone: final moment	0.3	0.5	1.1	-0.3	-0.4	0.2	1.0	-0.7	0.9
Food consumed during 24 hour testing period	1.0	1.3	3.1	0.3	0.5	-0.5	-1.7	1.2	-1.7
Glucose	0.2	0.3	0.8	0.8	0.7	0.9	-0.3	0.4	0.1
Heart weight	0.8	1.2	1.7	-1.3	-1.2	-0.9	1.1	-1.3	0.8
Delay discount hyperbolic model param	0.9	1.0	1.6	-0.9	-1.0	-0.5	1.3	-1.1	1.0
Intermittent access intake day 1-15 change	0.3	0.5	1.3	-0.1	-0.3	0.3	1.1	-0.8	1.0
Intermittent access intake escalation	0.2	0.5	1.2	0.0	-0.2	0.4	1.1	-0.7	1.0
Intermittent access intake escalation 2	0.9	1.0	2.4	-0.2	-0.4	0.4	1.6	-1.1	1.4
Intermitt. access day 1 inactive lever presses	2.1	7.9	10.0	2.9	3.1	2.0	-2.9	3.2	-2.7
Intermitt. access day 15 inactive lever presses	1.5	3.1	4.7	1.6	1.7	0.8	-2.2	2.2	-1.8
Intermitt. access escalation Index	0.2	0.2	0.6	-0.6	-0.6	-0.7	0.2	-0.3	-0.1
Intermittent access day 1 total infusions	1.2	2.0	3.0	1.4	1.3	1.1	-1.7	1.3	-1.7
Intermittent access day 15 total infusions	0.6	0.9	1.3	1.1	1.0	1.0	-1.0	0.8	-0.9
Intermittent access terminal intake (last 3 days)	0.8	1.0	1.9	1.2	1.1	1.4	-0.9	0.6	-0.7
Intermittent access total infusions	2.5	2.9	3.7	1.9	1.8	1.8	-1.9	1.4	-1.4
Intermittent access day 1 locomotion	2.3	2.9	6.6	0.8	1.1	0.0	-2.4	1.8	-2.6
Intermittent access day 15 total locomotion	0.5	0.9	1.4	0.8	0.9	0.6	-1.2	0.9	-1.1
Intermittent access total locomotion	2.1	2.5	3.2	1.6	1.6	1.3	-1.8	1.5	-1.5
Intermittent access standard deviation	0.1	0.3	0.9	0.5	0.2	1.0	0.2	-0.5	0.5
Left kidney weight	2.6	11.9	16.5	-4.1	-3.9	-3.4	3.2	-3.3	2.6
Right kidney weight	1.7	7.7	11.1	-3.3	-3.3	-3.1	2.4	-2.6	1.7
Cocaine induced anxiety	0.5	0.7	1.7	-0.7	-0.6	-1.3	-0.7	0.1	-1.0
Post-drug Anxiety	0.8	0.9	1.6	-1.1	-1.2	-1.3	0.5	-0.9	0.1
Baseline Anxiety	0.2	0.3	0.8	0.1	0.0	0.5	0.7	-0.3	0.9
Tail length	3.0	11.6	29.9	-4.7	-3.8	-5.5	0.4	-1.4	-1.0
Length with tail	3.8	16.5	37.0	-5.7	-4.7	-6.1	1.4	-2.4	0.0
Length without tail	2.5	8.1	18.6	-3.9	-3.3	-4.3	0.9	-1.8	-0.1
Times rat made contact with spout	0.7	0.8	2.4	1.3	1.0	1.5	-0.0	0.2	0.3
Lifetime Intake	1.1	1.4	2.1	1.2	1.1	1.1	-1.5	0.9	-1.2
Liver weight, left	0.2	0.3	1.0	-0.7	-0.5	-1.0	-0.1	-0.0	-0.3
Liver weight, right	1.5	2.7	4.1	-2.0	-2.0	-1.8	1.2	-1.6	0.9
Locomotor activity	1.4	2.2	3.8	-1.5	-1.4	-1.1	1.9	-1.3	1.6
Locomotor testing distance	0.5	0.9	2.4	-0.2	-0.3	0.3	1.5	-0.7	1.5
Locomotor testing rearing	0.2	0.5	1.2	0.5	0.3	0.8	1.1	-0.2	0.8
Locomotion in novel chamber	0.4	0.5	0.7	0.8	0.7	0.8	-0.6	0.5	-0.3
Locomotion in novel chamber post-restriction	0.1	0.1	0.3	-0.2	-0.0	-0.2	-0.5	0.2	-0.5
Fecal boli incidents, locomotor time 1	0.3	0.4	0.7	-0.9	-0.8	-0.7	0.4	-0.6	0.5
Change in fecal boli incidents, locomotor task	1.1	1.1	2.0	1.4	1.3	1.2	-0.6	0.9	-0.7
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	0.1	0.0	0.0	0.5	0.1	0.4
Bouts of movement, locomotor time 1	0.7	0.8	1.5	-0.8	-1.0	-0.5	1.0	-1.2	0.7
Total resting periods, locomotor time 1	0.5	0.6	1.1	-0.6	-0.8	-0.3	0.9	-1.0	0.5
Rest time, locomotor task time 1	0.1	0.1	0.3	0.3	0.2	0.6	0.3	-0.2	0.2
Distance moved, locomotor task time 1	0.3	0.4	1.1	0.5	0.3	0.7	0.6	-0.1	1.1
Vertical activity count, locomotor time 1	0.6	1.4	2.9	-0.8	-1.0	-0.4	1.5	-1.3	1.7
Time >=10cm from walls, locomotor time 2	0.3	0.4	0.6	0.8	0.8	0.7	-0.4	0.7	-0.2
Bouts of movement, locomotor time 2	0.4	0.7	1.6	0.2	-0.0	0.8	1.3	-0.6	1.3
Total resting periods, locomotor time 2	0.6	1.1	2.5	0.1	-0.2	0.8	1.6	-0.9	1.6
Rest time, locomotor task time 2	1.1	1.4	2.9	-0.1	-0.5	0.6	1.7	-1.4	1.6
Distance moved, locomotor task time 2	0.5	0.5	1.1	-0.2	0.0	-0.8	-1.0	0.7	-1.0
Vertical activity count, locomotor time 2	0.6	0.8	1.6	-1.1	-1.0	-1.3	0.4	-0.6	0.5
Light reinforcement 1	1.2	2.8	6.4	-2.2	-2.0	-2.5	0.5	-1.1	0.2
Light reinforcement 2	0.2	0.4	0.9	0.2	0.2	-0.3	-0.8	0.6	-0.9
Bone: marrow area	0.3	0.7	1.3	-0.1	-0.5	0.4	1.0	-1.1	1.1
Bone: maximum diameter	0.9	1.6	2.0	-1.4	-1.4	-1.0	1.3	-1.4	1.1
Bone: maximum force	0.3	0.6	1.3	-0.5	-0.6	-0.1	1.2	-0.9	0.9
Bone: maximum moment	0.2	0.4	1.1	-0.3	-0.4	0.2	1.0	-0.7	0.9
Mean time between licks in bursts	0.7	1.7	4.1	-0.5	-0.8	0.3	1.8	-1.5	2.0
Mean num. licks in bursts	1.6	2.5	4.0	2.0	1.9	2.0	-1.0	1.3	-0.7
Cd content in liver	2.1	2.3	3.5	-1.6	-1.7	-1.0	1.5	-1.9	1.3
Co content in liver	0.0	0.0	0.0	-0.1	-0.1	-0.1	-0.0	-0.1	-0.2
Cu content in liver	0.5	0.6	1.3	0.4	0.5	-0.2	-0.9	1.1	-1.2
Fe content in liver	0.2	0.3	0.7	-0.1	-0.1	0.4	0.7	-0.5	0.8
K content in liver	0.4	0.4	0.6	0.6	0.7	0.4	-0.4	0.8	-0.6
Mg content in liver	0.7	0.7	1.1	1.0	1.0	0.8	-0.4	0.8	-0.8
Mn content in liver	0.2	0.2	0.8	0.1	-0.0	0.3	0.9	-0.3	0.6
Na content in liver	0.7	0.8	1.6	0.6	0.9	0.2	-0.7	1.2	-1.1
Rb content in liver	1.2	1.4	2.6	0.9	1.1	0.4	-1.4	1.3	-1.6
Se content in liver	0.3	0.3	0.5	0.6	0.7	0.3	-0.4	0.7	-0.7
Sr content in liver	1.6	1.4	3.2	0.4	0.6	-0.3	-1.8	1.2	-1.8
Zn content in liver	1.1	1.2	3.1	-1.3	-1.2	-1.8	-0.5	-0.4	-0.8
Bone: minimum diameter	3.6	6.7	8.5	-2.9	-2.9	-2.3	2.5	-2.7	2.1
Time in familiar zone, hab. session 1	0.3	0.3	0.5	-0.5	-0.3	-0.7	-0.5	0.1	-0.6
Time in novel zone, hab. session 1	0.2	0.2	0.4	0.3	0.1	0.5	0.7	-0.3	0.6
Total zone transitions, hab. session 1	1.8	2.5	5.7	-0.5	-1.0	0.4	2.1	-1.8	2.4
Total locomotion distance, hab. session 1	2.0	2.8	6.9	-0.1	-0.6	1.0	2.3	-1.8	2.6
Locomotion velocity, hab. session 1	2.2	3.1	7.9	0.2	-0.5	1.4	2.3	-1.8	2.8
Time in familiar zone, hab. session 2	0.0	0.0	0.1	-0.1	-0.1	0.0	0.1	-0.1	0.3
Time in novel zone, hab. session 2	0.1	0.1	0.3	0.5	0.5	0.5	-0.1	0.2	-0.1
Total zone transitions, hab. session 2	1.1	1.3	2.7	-0.4	-0.8	0.3	1.4	-1.5	1.7
Total locomotion distance, hab. session 2	2.3	3.0	7.5	0.1	-0.6	1.2	2.3	-1.9	2.7
Locomotion velocity, hab. session 2	2.2	2.9	7.0	0.1	-0.7	1.1	2.3	-1.9	2.7
Novel to familiar place preference ratio	2.7	2.9	5.5	0.9	1.3	-0.0	-2.2	2.1	-2.3
Novelty place preference	3.0	3.2	5.9	1.0	1.4	0.0	-2.3	2.2	-2.4
Time in novel zone, NPP test	2.4	2.6	4.8	0.9	1.3	-0.1	-2.1	2.1	-2.2
Total zone transitions, NPP test	0.4	0.6	0.7	-0.8	-0.9	-0.7	0.7	-0.8	0.7
Total locomotion distance, NPP test	0.6	0.8	1.9	0.3	-0.1	0.7	1.1	-0.9	1.4
Locomotion velocity, NPP test	0.6	0.8	1.8	0.6	0.1	1.1	1.0	-0.7	1.3
Intraocular pressure	2.0	2.8	5.0	1.4	1.4	0.7	-2.2	1.8	-2.0
Delta distance traveled before/after self-admin	0.4	0.4	0.5	0.7	0.7	0.7	-0.6	0.5	-0.4
Delta ambulatory time before/after self-admin	1.0	1.3	2.0	1.3	1.4	1.4	-0.9	0.9	-0.5
Parametrial fat weight	1.2	2.9	3.7	-1.9	-1.9	-1.5	1.7	-1.7	1.3
Pavlov. Cond. lever latency	0.6	0.7	1.9	-1.1	-1.0	-1.4	0.2	-0.3	-0.4
Pavlov. Cond. magazine entry latency	1.4	1.8	4.2	-0.6	-0.9	0.0	1.7	-1.6	2.0
Pavlov. Cond. change in total contacts	0.7	0.8	2.4	0.3	-0.0	0.8	0.9	-0.8	1.6
Pavlov. Cond. index score	0.3	0.3	1.1	0.2	-0.1	0.6	0.5	-0.6	1.1
Pavlov. Cond. latency score	0.3	0.3	0.9	0.4	0.2	0.8	0.3	-0.5	0.9
Pavlov. Cond. lever contacts	0.2	0.3	0.8	0.7	0.5	0.9	-0.1	0.0	0.4
Pavlov. Cond. magazine entry number	1.9	2.4	4.8	1.0	1.3	0.3	-1.8	1.8	-2.2
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.7	0.7	0.8	0.6	-0.6	0.8	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.6	0.0	-0.2	0.5	0.7	-0.8	1.3
Pavlov. Cond. response bias	0.7	0.9	2.8	0.1	-0.2	0.7	1.1	-0.9	1.7
Pavlov. Cond. lever latency	0.4	0.5	1.1	0.9	0.8	1.1	-0.5	0.4	-0.3
Pavlov. Cond. magazine entry latency	0.5	0.6	0.7	-0.8	-0.8	-0.6	0.7	-0.8	0.7
Pavlov. Cond. change in total contacts	0.2	0.3	0.4	-0.7	-0.6	-0.6	0.3	-0.5	0.4
Pavlov. Cond. index score	0.5	0.6	1.0	-1.0	-0.9	-1.0	0.6	-0.7	0.5
Pavlov. Cond. latency score	0.3	0.3	0.5	-0.7	-0.7	-0.7	0.4	-0.5	0.4
Pavlov. Cond. lever contacts	0.4	0.5	1.2	-0.9	-0.8	-1.1	0.4	-0.5	0.2
Pavlov. Cond. magazine entry number	1.0	1.3	1.7	1.1	1.2	0.8	-1.2	1.3	-1.1
Pavlov. Cond. intertrial magazine entries	0.8	1.2	2.2	-1.2	-1.0	-0.8	1.5	-0.9	1.1
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.6	0.8	-0.9	-0.8	-0.8	0.6	-0.7	0.6
Pavlov. Cond. response bias	0.9	1.2	1.9	-1.4	-1.3	-1.4	0.7	-1.0	0.6
Time in closed arm before self-admin	2.2	2.8	3.8	-1.8	-1.9	-1.7	1.6	-1.8	1.1
Time in closed arm after self-admin	1.8	1.9	2.6	-1.5	-1.6	-1.3	1.3	-1.5	1.1
Time in open arm before self-admin	2.0	2.1	4.4	1.8	1.8	2.1	-0.7	1.2	-0.1
Time in open arm after self-admin	1.7	1.9	2.7	1.2	1.4	0.8	-1.5	1.6	-1.4
Bone: periosteal estimation	0.8	1.6	2.4	-1.2	-1.3	-0.7	1.4	-1.6	1.3
Bone: periosteal perimeter	0.4	0.7	1.0	-1.0	-1.0	-0.7	0.8	-1.0	0.6
Bone: post-yield work	0.1	0.1	0.2	-0.3	-0.1	-0.3	-0.4	0.2	-0.4
Progressive ratio test 1 active lever presses	0.9	1.1	2.8	0.6	0.6	0.2	-1.7	0.8	-1.6
Progressive ratio test 1 breakpoint	0.8	1.0	2.6	0.5	0.5	0.2	-1.6	0.8	-1.5
Progressive ratio test 1 inactive lever presses	1.7	2.5	3.1	1.6	1.6	1.0	-1.8	1.7	-1.6
Progressive ratio test 2 active lever presses	0.4	0.5	0.6	0.7	0.7	0.8	-0.8	0.4	-0.7
Progressive ratio test 2 breakpoint	0.4	0.5	0.7	0.8	0.7	0.8	-0.7	0.3	-0.6
Progressive ratio test 2 inactive lever presses	1.6	2.6	3.6	1.9	1.8	1.7	-1.5	1.5	-1.0
Incentive Sensitization - Responses	0.1	0.1	0.3	0.4	0.4	0.5	-0.4	0.1	-0.4
Incentive Sensitization - Breakpoint	0.1	0.1	0.3	0.4	0.4	0.5	-0.3	0.1	-0.3
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.5	-0.7	-0.7	-0.7	0.2	-0.6	-0.1
Progressive ratio	0.1	0.1	0.3	0.3	0.3	0.6	0.2	-0.1	-0.0
Food seeking constrained by brief footshock	0.1	0.1	0.3	-0.0	-0.0	-0.3	-0.6	0.2	-0.4
Seeking ratio, punishment vs. effort	0.2	0.2	0.7	-0.0	0.0	-0.5	-0.9	0.5	-0.4
Retroperitoneal fat weight	1.1	4.7	6.8	-2.6	-2.6	-2.6	1.7	-1.9	1.2
Reaction time number correct	0.0	0.1	0.2	-0.1	-0.2	-0.3	-0.1	-0.1	-0.5
Reaction time mean minus median	0.1	0.3	0.8	0.7	0.6	0.9	0.3	0.2	0.3
Reaction time mean minus median AUC	0.3	0.8	2.0	1.2	1.1	1.4	-0.2	0.6	0.0
Reaction time num false alarms	2.0	2.8	3.5	1.7	1.9	1.2	-1.6	1.9	-1.7
Reaction time num false alarms AUC	2.3	3.6	4.5	2.0	2.1	1.4	-1.8	2.1	-1.9
Reaction time trials correct on left	0.0	0.1	0.2	-0.1	-0.2	-0.3	-0.1	-0.1	-0.5
Reaction time trials on left	0.0	0.0	0.2	-0.0	-0.1	-0.2	-0.1	-0.0	-0.5
Reaction time mean	0.7	1.0	2.4	-0.2	-0.5	0.4	1.5	-1.1	1.5
Reaction time mean AUC	0.6	0.9	2.1	-0.1	-0.4	0.5	1.4	-1.0	1.5
Median of all reaction times	1.2	1.7	3.6	-0.5	-0.9	0.1	1.8	-1.5	1.9
Reaction time omissions	1.1	1.6	3.6	1.8	1.5	1.9	-0.1	0.8	0.0
Reaction time false alarm rate	1.9	2.6	3.7	1.9	1.9	1.6	-1.3	1.7	-1.1
Reaction time premature initiation rate	3.4	4.7	7.0	-1.7	-2.1	-1.0	2.7	-2.6	2.4
Reaction time premature initiations	1.8	3.2	4.8	-1.6	-1.9	-1.1	2.1	-2.2	1.6
Std. dev. reaction times	0.2	0.4	0.7	0.5	0.3	0.8	0.8	-0.3	0.8
Reaction time trials completed	0.0	0.0	0.2	-0.0	-0.1	-0.2	-0.1	-0.0	-0.5
Reaction time trials AUC	0.0	0.1	0.1	-0.2	-0.3	-0.3	0.2	-0.3	-0.2
Run reversals in cocaine runway, females	6.5	6.5	9.8	-2.5	-2.9	-1.7	2.5	-3.1	2.3
Run reversals in cocaine runway, males	3.2	3.2	5.6	1.4	1.8	0.6	-2.2	2.4	-1.9
Latency to leave start box in cocaine runway	0.2	0.2	0.4	-0.5	-0.4	-0.3	0.6	-0.4	0.6
Latency to leave start box in cocaine runway, F	0.3	0.4	0.7	0.7	0.8	0.8	-0.2	0.6	0.1
Latency to leave start box in cocaine runway, M	2.1	2.0	3.4	-1.8	-1.7	-1.8	0.9	-1.1	0.4
Std. dev. time between licks in bursts	0.7	1.0	1.2	-1.0	-1.1	-0.8	1.0	-1.1	0.9
Total sessions with >9 infusions	0.4	0.5	1.5	0.3	0.3	0.1	-1.2	0.4	-1.1
Short access day 1 total inactive lever presses	1.6	2.1	3.4	1.3	1.4	1.0	-1.7	1.3	-1.8
Short access day 10 total inactive lever presses	1.3	3.2	4.5	1.6	1.9	1.0	-1.8	2.1	-2.0
Short access day 1 total infusions	0.2	0.3	0.9	-0.5	-0.7	-0.2	0.1	-0.9	0.0
Short access day 10 total infusions	1.3	1.7	3.1	1.0	1.1	0.6	-1.8	1.4	-1.6
Short access total infusions	0.1	0.2	0.4	-0.3	-0.3	-0.3	-0.6	-0.2	-0.7
Short access day 1 locomotion	0.6	0.8	1.7	0.5	0.6	0.2	-1.2	0.8	-1.3
Short access day 10 total locomotion	0.7	1.3	1.9	1.4	1.3	1.2	-1.1	1.0	-0.9
Short access total locomotion	1.6	2.0	3.6	1.0	1.2	0.5	-1.9	1.4	-1.9
One hour access (0.3 mA shock)	0.2	0.2	0.6	0.3	0.0	0.8	0.3	-0.6	0.3
Compulsive drug intake	0.0	0.0	0.0	-0.1	-0.1	-0.0	0.1	-0.1	0.0
One hour access (shock baseline)	0.2	0.3	0.9	0.7	0.5	1.0	-0.2	0.0	-0.1
Social response proportion	4.1	4.7	6.5	-2.3	-2.5	-1.7	2.0	-2.5	1.8
Social responses	3.0	3.9	6.5	-1.4	-1.7	-0.6	2.5	-2.3	2.5
Social time	0.6	0.9	2.1	0.3	-0.0	1.0	1.2	-0.9	1.5
Soleus weight	0.9	2.7	3.6	-1.8	-1.9	-1.3	1.5	-1.8	1.5
Bone: stiffness	2.8	4.6	8.0	-1.7	-1.9	-0.8	2.8	-2.3	2.6
Tibialis anterior weight	1.4	4.7	12.1	0.1	-0.4	1.8	3.0	-2.0	3.5
Time to tail flick, vehicle, before self-admin	1.3	1.4	2.4	-1.4	-1.6	-1.4	0.6	-1.3	0.3
Time to tail flick, vehicle, after self-admin	0.3	0.4	1.2	0.8	0.6	1.1	-0.2	0.1	0.3
Time to tail flick, test, before self-admin	0.6	0.6	1.1	-1.1	-0.9	-0.8	0.6	-0.7	0.3
Time to tail flick, test, after self-admin	1.0	1.0	1.5	-1.0	-1.0	-0.5	1.2	-1.1	1.1
Delta time to tail flick, vehicle, before/after SA	2.3	2.2	3.7	1.8	1.8	1.9	-1.1	1.3	-0.5
Delta time to tail flick, test, before/after SA	0.0	0.0	0.0	0.1	-0.0	-0.1	-0.0	0.1	-0.1
Tibia length	6.2	17.2	27.6	-5.3	-5.0	-4.9	2.8	-3.8	2.1
Ambulatory time before self-admin	1.6	2.4	4.9	-1.9	-1.9	-2.2	0.5	-1.2	-0.1
Ambulatory time after self-admin	0.6	0.7	1.4	-1.1	-0.9	-1.2	-0.4	-0.5	-0.7
Bone: tissue strength	0.7	0.7	1.8	-0.5	-0.6	-0.2	1.4	-0.9	1.0
Total heroin consumption	0.3	0.4	0.6	0.7	0.7	0.4	-0.4	0.8	-0.5
Bone: trabecular number	0.2	0.3	0.6	-0.4	-0.4	0.0	0.8	-0.7	0.6
Bone: trabecular spacing	0.7	0.9	1.4	0.7	1.0	0.5	-1.1	1.2	-1.0
Bone: trabecular thickness	1.5	1.9	3.2	-1.8	-1.6	-1.5	1.0	-1.3	0.7
Bone: trabecular tissue density	0.1	0.1	0.3	-0.3	-0.3	-0.1	0.5	-0.4	0.5
Water consumed over 24 hours	0.3	0.5	1.1	-0.3	-0.2	-0.7	-1.0	0.3	-1.0
Number of responses in last shaping day	0.7	0.8	1.0	0.9	1.0	0.9	-0.9	0.9	-0.6