Nedd1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	mRNA stability	Nedd1	0.06	0.03	1.2e-07	0.05	0.06	0.05	0.05	1.7e-06	6.7e-07	1.2e-06	2.3e-06
2	Liver	mRNA stability	Nedd1	0.05	0.03	5.3e-05	0	0.02	0.01	0.01	1.9e-01	1.3e-03	3.1e-02	1.3e-02
3	Liver	gene expression	Nedd1	0.18	0.07	0.0e+00	0.2	0.22	0.21	0.21	1.3e-21	1.6e-23	4.5e-23	4.8e-23
4	PL	gene expression	Nedd1	0.1	0.05	4.0e-09	0.07	0.08	0.05	0.07	2.2e-08	1.1e-08	5.1e-06	4.2e-08
5	Brain	mRNA stability	Nedd1	0.06	0.03	3.6e-05	0.05	0.04	0.03	0.04	4.2e-05	4.7e-05	3.4e-04	2.3e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.5	0.8	2.1	-0.5	-0.6	0.2	1.2	1.5
Area under the delay curve	0.9	1.0	1.2	1.0	1.1	0.9	-1.1	-0.8
BMI with tail	0.9	2.8	3.8	-1.7	-1.9	-1.0	1.9	1.7
BMI without tail	1.0	2.1	3.1	-1.7	-1.8	-1.3	1.3	1.0
Body weight	3.7	15.6	24.9	-5.0	-4.6	-4.8	2.3	1.6
Weight adjusted by age	1.9	2.1	3.4	-1.8	-1.8	-1.7	0.9	0.5
Bone surface	0.2	0.4	0.8	0.1	-0.1	0.6	0.9	0.9
Bone volume	0.7	1.2	2.7	-0.6	-0.8	0.2	1.6	1.6
Breakpoint value in progressive ratio session	0.3	0.3	0.4	0.6	0.3	0.6	0.6	0.6
Number of licking bursts	0.5	0.5	1.0	-0.7	-0.8	-0.5	0.6	1.0
Context. condit. distance diff. score	0.6	0.8	1.2	-1.1	-1.0	-1.1	0.6	0.3
Locomotion velocity, session 1	1.4	1.5	1.9	1.3	1.4	0.9	-1.3	-1.1
Locomotion distance, session 1	0.3	0.3	0.4	0.6	0.6	0.6	-0.6	-0.4
Locomotion velocity, session 2	0.4	0.5	1.1	0.0	0.3	-0.4	-1.0	-1.1
Locomotion distance, session 2	0.0	0.0	0.1	0.0	-0.1	0.3	-0.3	-0.1
Locomotion velocity, session 3	0.2	0.3	0.5	-0.7	-0.6	-0.7	0.2	0.2
Locomotion distance, session 3	1.8	1.9	3.3	-1.7	-1.7	-1.8	0.6	0.5
Stereotopy head waving bouts, day 3	0.8	0.9	2.1	1.1	0.7	1.4	0.5	0.6
Stereotopy head waving duration, day 3	1.0	1.2	2.6	1.4	1.2	1.6	-0.1	0.1
Locomotion velocity, session 7	0.3	0.3	0.8	-0.4	-0.2	-0.9	-0.6	-0.5
Locomotion distance, session 7	0.4	0.5	1.2	-0.2	-0.0	-0.8	-1.1	-0.7
Stereotopy head waving bouts, day 7	0.4	0.5	1.2	0.1	0.4	-0.5	-0.8	-1.1
Stereotopy head waving duration, day 7	0.2	0.3	0.9	-0.0	0.2	-0.4	-0.5	-0.9
Locomotion velocity, session 8	0.6	0.7	1.5	-0.1	0.1	-0.5	-1.2	-1.2
Locomotion distance, session 8	1.0	1.5	2.6	-1.6	-1.6	-1.3	0.7	0.6
Degree of sensitization distance	1.7	1.7	2.4	1.3	1.5	0.8	-1.6	-1.3
Degree of sensitization stereotypy	0.7	0.7	2.0	-0.1	0.2	-0.8	-1.0	-1.4
Conditioned locomotion	1.0	1.2	2.7	-0.7	-0.9	-0.5	1.7	1.2
Cocaine response after cond. corrected	1.9	2.1	5.5	0.2	0.7	-0.6	-2.3	-2.0
Cocaine response after cond. not corrected	1.8	2.0	5.4	0.5	0.9	-0.2	-2.3	-1.9
Cocaine response before conditioning	0.4	0.5	1.0	0.6	0.3	1.0	0.7	0.8
Saline control response	0.2	0.3	0.6	0.5	0.5	0.1	-0.6	-0.8
Bone: connectivity density	0.1	0.2	0.4	0.4	0.5	0.3	-0.6	-0.4
Bone: cortical apparent density	2.7	3.6	5.6	-2.4	-2.2	-2.1	1.5	1.0
Bone: cortical area	1.6	2.4	3.0	-1.7	-1.7	-1.4	1.6	1.3
Bone: cortical porosity	0.6	0.6	1.1	0.9	1.0	0.8	-0.5	-0.6
Bone: cortical porosity	0.3	0.3	0.7	0.7	0.7	0.8	-0.1	-0.1
Bone: cortical thickness	1.0	1.7	2.5	-1.6	-1.4	-1.3	1.3	0.8
Bone: cortical thickness	0.0	0.0	0.1	-0.1	0.2	-0.2	-0.2	-0.2
Bone: cortical tissue density	2.5	3.3	5.3	-2.3	-2.1	-2.1	1.4	0.9
Condit. Reinf. active minus inactive responses	2.3	2.6	6.9	1.8	1.4	2.6	0.4	0.5
Condit. Reinf. active-inactive response ratio	1.9	2.0	5.4	1.5	1.1	2.3	0.8	0.8
Condit. Reinf. active responses	4.7	5.7	11.8	3.0	2.6	3.4	-0.8	-0.5
Condit. Reinf. inactive responses	2.6	3.0	3.9	2.0	2.0	1.6	-1.8	-1.3
Incentive salience index mean	1.8	2.2	6.2	1.7	1.3	2.5	0.2	0.5
Condit. Reinf. lever presses	0.3	0.3	1.2	0.5	0.3	1.1	-0.0	0.5
Condit. Reinf. active minus inactive responses	0.5	0.6	1.4	-0.4	-0.5	0.0	1.2	1.1
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.2	-0.1	-0.0	0.2	0.4
Condit. Reinf. active responses	1.1	1.5	3.2	-0.7	-1.0	-0.1	1.8	1.6
Condit. Reinf. inactive responses	0.6	0.7	1.6	-0.5	-0.7	-0.2	1.3	1.1
Condit. Reinf. lever presses	0.7	1.0	2.0	-1.2	-1.0	-1.4	0.7	0.1
Condit. Reinf. lever reinforcers received	0.9	1.3	2.8	-0.7	-0.9	-0.2	1.7	1.5
Conditioned reinforcement - actives	0.5	0.5	1.5	0.1	-0.2	0.5	0.7	1.2
Conditioned reinforcement - inactives	0.8	0.9	1.7	0.5	0.8	0.2	-1.3	-1.3
Conditioned locomotion	0.0	0.0	0.0	-0.2	-0.2	-0.2	-0.1	0.0
Patch foraging indifference point 0 sec	0.1	0.2	0.5	0.3	0.5	0.1	-0.2	-0.7
Patch foraging indifference point AUC	0.3	0.3	0.8	-0.1	0.1	-0.4	-0.9	-0.8
Delay disc. indifference point, 0s delay	0.8	0.9	1.3	1.1	1.0	0.9	-0.8	-0.8
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	0.3	0.1	0.4	-0.2	0.4
Delay disc. indifference point, 2s delay	0.9	1.0	1.7	1.0	1.0	0.4	-1.3	-1.0
Delay disc. indifference point, 24s delay	0.3	0.3	1.0	0.5	0.4	1.0	-0.1	0.2
Delay disc. indifference point, 4s delay	2.1	2.2	2.8	1.4	1.6	1.0	-1.6	-1.7
Delay disc. indifference point, 8s delay	0.4	0.4	0.6	0.5	0.6	0.4	-0.8	-0.7
Indifference point function ln k	0.0	0.0	0.1	0.2	0.2	0.2	0.1	0.1
Indifference point function log k	0.0	0.0	0.1	0.2	0.2	0.2	0.1	0.1
Patch foraging total patch changes 0 sec	0.1	0.1	0.4	0.1	0.4	-0.1	-0.1	-0.6
Patch foraging total patch changes 12 sec	0.3	0.4	0.9	-0.8	-0.6	-1.0	0.1	-0.3
Patch foraging total patch changes 18 sec	0.1	0.1	0.3	-0.1	0.0	-0.6	-0.4	-0.3
Patch foraging total patch changes 24 sec	0.2	0.3	0.7	0.3	0.5	-0.1	-0.7	-0.8
Patch foraging total patch changes 6 sec	0.4	0.6	0.9	0.9	0.9	0.9	-0.1	-0.6
Patch foraging time to switch 0 sec	0.8	1.2	2.8	-0.4	-0.7	0.1	1.7	1.5
Patch foraging water rate 0 sec	0.2	0.4	0.6	-0.7	-0.8	-0.5	0.4	0.6
Patch foraging water rate 12 sec	0.1	0.1	0.3	0.0	0.1	-0.1	-0.5	-0.4
Patch foraging water rate 18 sec	0.3	0.4	0.8	-0.6	-0.8	-0.2	0.9	0.5
Patch foraging water rate 24 sec	1.7	2.4	3.6	-1.8	-1.9	-1.7	1.1	1.2
Patch foraging water rate 6 sec	3.7	5.4	8.0	-2.7	-2.8	-2.4	1.7	1.9
Seeking ratio, delayed vs. immediate footshock	0.6	0.7	1.2	0.8	1.0	0.6	-1.1	-0.6
Distance traveled before self-admin	1.2	1.3	2.0	-1.4	-1.4	-1.3	0.8	0.4
Distance traveled after self-admin	0.5	0.6	1.1	-1.0	-0.9	-1.1	-0.3	-0.2
Extensor digitorum longus weight	0.7	2.7	7.2	-0.4	-0.9	0.9	2.7	2.2
Bone: elastic displacement	1.5	1.7	2.4	1.6	1.5	1.4	-0.9	-0.9
Bone: elastic work	1.3	1.7	2.7	1.6	1.6	1.6	-0.6	-0.4
Bone: endosteal estimation	0.4	0.8	2.0	-0.1	-0.5	0.5	1.1	1.4
Bone: endosteal perimeter	0.7	1.4	2.1	-1.3	-1.4	-1.0	1.1	1.1
Epididymis fat weight	2.4	5.7	11.5	-2.9	-2.7	-3.4	0.9	-0.0
Delta time in closed arm before/after self-admin	0.0	0.0	0.1	0.1	0.1	0.2	-0.2	-0.0
Delta time in open arm before/after self-admin	0.5	0.5	1.0	0.5	0.7	0.1	-0.8	-1.0
Diff in mean of infusions in LGA sessions	2.4	2.7	4.8	2.2	2.0	2.0	-0.6	-0.5
Delay discount exponential model param	0.9	0.9	1.4	-0.9	-1.0	-0.7	1.2	0.9
Extinction: sum of active levers before priming	3.0	3.0	4.4	2.1	1.9	2.0	-1.3	-0.9
Active lever presses in extinction session 6	1.2	1.1	3.1	1.3	1.0	1.7	0.0	0.2
Bone: final force	0.7	1.2	3.0	-0.7	-0.8	-0.2	1.3	1.7
Bone: final moment	0.6	1.0	2.8	-0.5	-0.6	0.0	1.2	1.7
Food consumed during 24 hour testing period	1.1	1.3	2.8	0.3	0.7	-0.5	-1.7	-1.7
Glucose	0.1	0.1	0.2	-0.2	-0.3	-0.0	0.3	0.4
Heart weight	0.2	0.2	0.4	-0.5	-0.3	-0.6	-0.4	-0.6
Delay discount hyperbolic model param	0.9	1.0	1.6	-0.9	-1.0	-0.6	1.3	1.1
Intermittent access intake day 1-15 change	0.6	0.6	1.1	0.3	0.0	0.8	1.1	1.0
Intermittent access intake escalation	0.3	0.3	0.5	0.4	0.2	0.7	0.6	0.5
Intermittent access intake escalation 2	0.6	0.6	1.5	0.8	0.6	1.2	0.6	0.5
Intermitt. access day 1 inactive lever presses	9.0	9.7	12.4	3.3	3.5	2.2	-3.3	-3.0
Intermitt. access day 15 inactive lever presses	3.8	4.2	6.7	1.8	2.1	0.6	-2.6	-2.5
Intermitt. access escalation Index	0.0	0.0	0.0	0.1	0.1	-0.1	-0.1	-0.0
Intermittent access day 1 total infusions	0.7	0.8	1.6	0.9	0.8	0.7	-1.3	-0.5
Intermittent access day 15 total infusions	0.3	0.4	0.8	0.8	0.6	0.9	-0.5	-0.1
Intermittent access terminal intake (last 3 days)	0.4	0.5	1.2	0.8	0.6	1.1	-0.5	0.1
Intermittent access total infusions	0.9	1.0	1.6	1.1	0.9	1.3	-1.1	-0.3
Intermittent access day 1 locomotion	1.0	1.0	3.1	0.3	0.5	-0.3	-1.8	-1.3
Intermittent access day 15 total locomotion	0.2	0.2	0.4	0.4	0.5	0.3	-0.7	-0.4
Intermittent access total locomotion	0.6	0.6	1.2	0.7	0.8	0.6	-1.1	-0.7
Intermittent access standard deviation	0.2	0.2	0.4	0.4	0.2	0.6	-0.6	-0.1
Left kidney weight	1.5	4.3	7.4	-2.7	-2.4	-2.7	1.1	0.4
Right kidney weight	1.6	4.4	9.3	-2.6	-2.3	-3.1	0.6	-0.0
Cocaine induced anxiety	1.1	1.2	2.5	-0.8	-0.4	-1.6	-0.9	-1.4
Post-drug Anxiety	0.6	0.6	1.6	-0.8	-0.6	-1.3	-0.4	-0.6
Baseline Anxiety	0.5	0.5	1.2	0.2	-0.0	0.6	0.9	1.1
Tail length	3.3	9.9	19.4	-4.1	-3.5	-4.4	1.0	0.4
Length with tail	5.0	18.5	38.7	-5.6	-4.7	-6.2	0.9	0.2
Length without tail	3.1	6.8	14.6	-3.4	-2.8	-3.8	0.6	0.1
Times rat made contact with spout	0.8	1.0	2.3	1.2	0.9	1.5	0.1	0.7
Lifetime Intake	0.1	0.1	0.3	0.2	0.0	0.5	-0.4	0.3
Liver weight, left	0.3	0.5	1.0	-0.6	-0.3	-1.0	-0.6	-1.0
Liver weight, right	3.0	4.9	7.2	-2.6	-2.7	-2.0	2.0	1.6
Locomotor activity	1.4	2.2	3.4	-1.4	-1.4	-1.1	1.9	1.6
Locomotor testing distance	0.4	0.7	1.7	-0.1	-0.2	0.2	1.3	1.3
Locomotor testing rearing	0.5	0.8	1.7	0.6	0.4	0.8	0.9	1.3
Locomotion in novel chamber	0.6	0.8	1.2	1.1	1.0	1.0	-0.9	-0.1
Locomotion in novel chamber post-restriction	0.4	0.5	1.0	0.5	0.5	0.4	-1.0	-0.9
Fecal boli incidents, locomotor time 1	0.4	0.4	0.6	-0.8	-0.7	-0.7	0.2	0.6
Change in fecal boli incidents, locomotor task	1.0	0.9	1.3	1.2	1.1	0.9	-0.6	-0.9
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.3	-0.0	-0.0	-0.2	0.5	0.1
Bouts of movement, locomotor time 1	0.8	0.8	1.1	-0.8	-1.0	-0.5	1.1	1.0
Total resting periods, locomotor time 1	0.6	0.6	1.0	-0.7	-0.9	-0.4	1.0	1.0
Rest time, locomotor task time 1	0.2	0.2	0.4	0.5	0.5	0.6	-0.1	-0.1
Distance moved, locomotor task time 1	0.3	0.4	0.6	0.5	0.3	0.8	0.7	0.6
Vertical activity count, locomotor time 1	1.2	1.3	2.7	-0.8	-1.1	-0.4	1.6	1.3
Time >=10cm from walls, locomotor time 2	0.4	0.4	0.6	0.8	0.8	0.6	-0.4	-0.6
Bouts of movement, locomotor time 2	0.6	0.6	1.3	0.2	-0.0	0.8	1.1	1.0
Total resting periods, locomotor time 2	0.9	0.9	2.1	0.1	-0.2	0.8	1.4	1.4
Rest time, locomotor task time 2	1.3	1.5	3.8	-0.2	-0.6	0.6	1.6	2.0
Distance moved, locomotor task time 2	0.5	0.6	1.7	-0.2	0.0	-0.8	-0.8	-1.3
Vertical activity count, locomotor time 2	0.8	0.8	1.7	-1.1	-1.0	-1.3	0.5	-0.1
Light reinforcement 1	1.9	3.5	7.2	-2.3	-2.1	-2.7	0.6	0.4
Light reinforcement 2	0.2	0.2	0.6	0.2	0.2	-0.3	-0.8	-0.6
Bone: marrow area	0.3	0.7	1.8	-0.1	-0.5	0.5	1.1	1.3
Bone: maximum diameter	0.9	1.6	2.0	-1.3	-1.4	-0.9	1.4	1.1
Bone: maximum force	0.5	0.9	2.4	-0.5	-0.6	-0.1	1.2	1.5
Bone: maximum moment	0.4	0.8	2.4	-0.2	-0.4	0.2	1.1	1.5
Mean time between licks in bursts	1.3	1.9	3.9	-0.9	-1.2	-0.1	1.8	2.0
Mean num. licks in bursts	1.9	2.3	3.5	1.9	1.8	1.9	-0.8	-0.8
Cd content in liver	5.2	5.7	7.7	-2.5	-2.8	-1.8	2.3	2.5
Co content in liver	0.5	0.6	1.3	-0.8	-0.7	-1.2	-0.2	-0.5
Cu content in liver	0.1	0.1	0.3	-0.3	-0.2	-0.6	-0.0	-0.4
Fe content in liver	0.2	0.3	0.8	-0.2	-0.2	0.3	0.7	0.9
K content in liver	0.4	0.4	0.7	0.8	0.8	0.5	-0.4	-0.6
Mg content in liver	0.4	0.4	0.7	0.9	0.8	0.7	-0.1	-0.2
Mn content in liver	0.5	0.6	1.2	0.4	0.2	0.8	1.1	1.1
Na content in liver	0.4	0.4	1.0	0.5	0.7	0.1	-0.5	-1.0
Rb content in liver	0.7	0.8	1.6	0.7	0.8	0.1	-1.2	-1.3
Se content in liver	0.0	0.0	0.1	0.2	0.2	-0.0	-0.2	0.0
Sr content in liver	1.4	1.3	3.1	0.1	0.3	-0.6	-1.7	-1.8
Zn content in liver	0.2	0.2	0.4	-0.5	-0.4	-0.6	-0.2	-0.4
Bone: minimum diameter	3.4	6.4	8.3	-2.7	-2.9	-2.2	2.5	2.3
Time in familiar zone, hab. session 1	0.3	0.3	0.4	-0.5	-0.3	-0.6	-0.5	-0.5
Time in novel zone, hab. session 1	0.2	0.2	0.4	0.3	0.1	0.4	0.7	0.6
Total zone transitions, hab. session 1	1.6	2.3	5.2	-0.6	-1.1	0.4	2.1	2.3
Total locomotion distance, hab. session 1	1.7	2.4	5.5	-0.1	-0.8	1.0	2.3	2.4
Locomotion velocity, hab. session 1	2.0	2.8	6.7	0.2	-0.6	1.4	2.3	2.6
Time in familiar zone, hab. session 2	0.0	0.0	0.1	-0.0	-0.1	0.0	0.0	-0.3
Time in novel zone, hab. session 2	0.2	0.2	0.3	0.4	0.5	0.5	0.0	0.5
Total zone transitions, hab. session 2	1.0	1.3	2.7	-0.6	-1.0	0.2	1.5	1.6
Total locomotion distance, hab. session 2	2.1	2.8	6.5	0.0	-0.7	1.1	2.4	2.6
Locomotion velocity, hab. session 2	2.1	2.8	6.5	-0.1	-0.8	1.0	2.4	2.6
Novel to familiar place preference ratio	2.2	2.2	4.6	0.9	1.4	-0.0	-2.2	-2.0
Novelty place preference	2.5	2.5	5.0	1.0	1.5	0.0	-2.2	-2.1
Time in novel zone, NPP test	2.0	2.0	4.0	0.9	1.3	-0.1	-2.0	-1.9
Total zone transitions, NPP test	0.4	0.6	0.9	-0.9	-0.9	-0.8	0.8	0.5
Total locomotion distance, NPP test	0.5	0.7	1.8	0.3	-0.2	0.7	1.2	1.3
Locomotion velocity, NPP test	0.6	0.9	1.7	0.6	0.1	1.0	1.1	1.3
Intraocular pressure	1.7	2.4	4.7	1.3	1.4	0.6	-2.2	-1.8
Delta distance traveled before/after self-admin	0.0	0.0	0.1	-0.2	-0.1	-0.2	-0.2	0.1
Delta ambulatory time before/after self-admin	0.2	0.2	0.4	0.5	0.6	0.5	-0.5	-0.3
Parametrial fat weight	0.1	0.1	0.3	-0.4	-0.4	-0.3	0.5	-0.0
Pavlov. Cond. lever latency	0.5	0.6	1.5	-1.0	-0.8	-1.2	0.1	-0.2
Pavlov. Cond. magazine entry latency	1.4	1.9	4.5	-0.7	-1.1	0.1	1.8	2.1
Pavlov. Cond. change in total contacts	0.6	0.6	1.5	0.3	-0.0	0.8	0.9	1.2
Pavlov. Cond. index score	0.2	0.3	0.7	0.2	-0.1	0.6	0.4	0.9
Pavlov. Cond. latency score	0.2	0.3	0.6	0.4	0.1	0.8	0.3	0.7
Pavlov. Cond. lever contacts	0.2	0.3	0.7	0.6	0.5	0.8	-0.2	0.2
Pavlov. Cond. magazine entry number	1.5	1.9	4.0	0.9	1.2	0.2	-1.8	-2.0
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.6	0.7	0.8	0.6	-0.5	-0.5
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	1.1	0.0	-0.2	0.5	0.6	1.0
Pavlov. Cond. response bias	0.6	0.7	1.9	0.1	-0.2	0.6	1.0	1.4
Pavlov. Cond. lever latency	0.2	0.3	0.8	0.6	0.4	0.9	-0.2	0.1
Pavlov. Cond. magazine entry latency	0.4	0.5	0.7	-0.8	-0.8	-0.6	0.7	0.5
Pavlov. Cond. change in total contacts	0.1	0.2	0.3	-0.6	-0.5	-0.5	0.4	0.2
Pavlov. Cond. index score	0.5	0.6	0.9	-0.9	-0.8	-1.0	0.6	0.3
Pavlov. Cond. latency score	0.2	0.3	0.5	-0.7	-0.6	-0.7	0.4	0.1
Pavlov. Cond. lever contacts	0.5	0.7	1.7	-1.0	-0.9	-1.3	0.4	0.1
Pavlov. Cond. magazine entry number	1.0	1.3	1.6	1.2	1.3	0.8	-1.2	-1.1
Pavlov. Cond. intertrial magazine entries	0.7	0.9	1.4	-1.1	-0.9	-0.8	1.2	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.7	-0.8	-0.8	-0.9	0.6	0.2
Pavlov. Cond. response bias	1.0	1.4	2.3	-1.4	-1.3	-1.5	0.8	0.5
Time in closed arm before self-admin	2.1	2.4	3.0	-1.7	-1.7	-1.4	1.5	1.4
Time in closed arm after self-admin	1.3	1.3	2.0	-1.3	-1.4	-1.0	1.0	0.9
Time in open arm before self-admin	1.6	1.8	2.9	1.6	1.6	1.7	-0.8	-0.4
Time in open arm after self-admin	1.2	1.3	1.9	1.3	1.4	0.9	-1.0	-1.1
Bone: periosteal estimation	0.8	1.6	2.4	-1.1	-1.3	-0.5	1.5	1.5
Bone: periosteal perimeter	0.7	1.1	1.3	-1.1	-1.1	-0.8	1.1	1.1
Bone: post-yield work	0.1	0.1	0.3	0.1	0.2	-0.0	-0.6	-0.5
Progressive ratio test 1 active lever presses	0.4	0.4	1.0	0.4	0.4	0.3	-1.0	-0.7
Progressive ratio test 1 breakpoint	0.1	0.1	0.5	0.1	0.1	0.2	-0.7	-0.4
Progressive ratio test 1 inactive lever presses	1.3	1.4	2.2	1.2	1.3	0.7	-1.5	-1.1
Progressive ratio test 2 active lever presses	0.2	0.2	0.4	0.4	0.3	0.6	-0.5	0.1
Progressive ratio test 2 breakpoint	0.1	0.1	0.4	0.4	0.2	0.6	-0.4	0.2
Progressive ratio test 2 inactive lever presses	2.5	2.9	3.7	1.9	1.8	1.8	-1.7	-1.1
Incentive Sensitization - Responses	0.4	0.4	0.6	0.6	0.6	0.8	-0.6	-0.1
Incentive Sensitization - Breakpoint	0.4	0.4	0.5	0.7	0.7	0.7	-0.7	-0.2
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.7	-0.5	-0.6	-0.3	0.4	0.8
Progressive ratio	0.3	0.4	0.8	0.7	0.7	0.9	-0.1	0.1
Food seeking constrained by brief footshock	0.1	0.1	0.6	0.2	0.2	-0.1	-0.7	-0.3
Seeking ratio, punishment vs. effort	0.2	0.2	0.5	0.0	0.0	-0.4	-0.7	-0.6
Retroperitoneal fat weight	1.4	4.7	6.8	-2.6	-2.6	-2.6	1.6	1.0
Reaction time number correct	0.0	0.0	0.1	0.0	-0.0	-0.2	-0.2	0.1
Reaction time mean minus median	0.3	0.4	0.9	0.8	0.7	0.9	0.1	0.4
Reaction time mean minus median AUC	0.8	1.1	2.2	1.3	1.1	1.5	-0.3	0.0
Reaction time num false alarms	1.8	2.5	3.5	1.7	1.9	1.1	-1.5	-1.6
Reaction time num false alarms AUC	2.4	3.2	4.6	2.0	2.2	1.3	-1.7	-1.7
Reaction time trials correct on left	0.0	0.0	0.1	0.0	-0.0	-0.2	-0.2	0.1
Reaction time trials on left	0.0	0.0	0.0	0.1	0.1	-0.1	-0.1	0.1
Reaction time mean	0.9	1.3	4.1	-0.1	-0.5	0.5	1.4	2.0
Reaction time mean AUC	0.8	1.1	3.4	0.0	-0.3	0.5	1.3	1.9
Median of all reaction times	1.3	1.8	5.4	-0.4	-0.8	0.2	1.7	2.3
Reaction time omissions	1.0	1.3	2.7	1.5	1.2	1.6	0.2	0.3
Reaction time false alarm rate	1.7	2.4	3.5	1.8	1.9	1.5	-1.2	-1.3
Reaction time premature initiation rate	3.6	4.8	7.8	-1.8	-2.2	-0.9	2.8	2.8
Reaction time premature initiations	2.5	3.5	5.6	-1.6	-1.9	-1.1	2.2	2.4
Std. dev. reaction times	0.4	0.6	1.3	0.5	0.3	0.8	0.8	1.1
Reaction time trials completed	0.0	0.0	0.0	0.1	0.1	-0.1	-0.1	0.1
Reaction time trials AUC	0.0	0.0	0.1	-0.1	-0.2	-0.2	0.1	0.4
Run reversals in cocaine runway, females	5.1	4.9	7.6	-2.1	-2.5	-1.2	2.2	2.7
Run reversals in cocaine runway, males	3.6	3.5	6.8	1.5	1.9	0.6	-2.2	-2.6
Latency to leave start box in cocaine runway	0.3	0.3	0.5	-0.6	-0.6	-0.4	0.7	0.1
Latency to leave start box in cocaine runway, F	0.1	0.2	0.3	0.3	0.4	0.4	-0.0	-0.5
Latency to leave start box in cocaine runway, M	2.3	2.2	3.6	-1.9	-1.7	-1.9	0.8	0.5
Std. dev. time between licks in bursts	0.7	0.8	1.0	-0.9	-1.0	-0.8	0.9	1.0
Total sessions with >9 infusions	0.1	0.1	0.6	0.0	-0.0	0.2	-0.8	0.0
Short access day 1 total inactive lever presses	3.8	4.3	5.6	2.2	2.2	1.8	-2.4	-1.8
Short access day 10 total inactive lever presses	1.6	1.8	2.4	1.2	1.6	0.6	-1.5	-1.5
Short access day 1 total infusions	0.9	0.9	2.1	-0.8	-1.1	-0.1	0.9	1.4
Short access day 10 total infusions	0.4	0.5	0.9	0.6	0.7	0.6	-1.0	-0.5
Short access total infusions	0.7	0.8	1.7	-0.8	-1.1	-0.3	0.7	1.3
Short access day 1 locomotion	0.0	0.0	0.2	0.0	0.0	0.1	-0.4	-0.3
Short access day 10 total locomotion	0.2	0.2	0.4	0.4	0.4	0.4	-0.6	-0.1
Short access total locomotion	0.4	0.4	1.4	0.3	0.4	0.1	-1.2	-0.6
One hour access (0.3 mA shock)	0.4	0.5	1.5	0.3	-0.0	0.9	0.3	1.2
Compulsive drug intake	0.6	0.6	0.7	-0.7	-0.8	-0.7	0.8	0.8
One hour access (shock baseline)	0.4	0.5	0.9	0.8	0.7	1.0	-0.6	-0.1
Social response proportion	3.6	4.0	6.0	-2.3	-2.4	-1.7	2.0	1.4
Social responses	2.6	3.3	6.6	-1.4	-1.8	-0.6	2.6	2.1
Social time	0.5	0.7	1.2	0.3	0.0	1.1	1.0	1.1
Soleus weight	0.7	2.1	3.1	-1.7	-1.8	-1.2	1.3	1.2
Bone: stiffness	3.4	5.3	9.6	-1.8	-2.1	-0.8	3.0	3.1
Tibialis anterior weight	1.1	3.7	7.8	0.3	-0.3	1.9	2.7	2.8
Time to tail flick, vehicle, before self-admin	1.8	1.8	2.9	-1.6	-1.7	-1.6	0.8	0.5
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.4	0.3	0.2	0.6	-0.1	0.1
Time to tail flick, test, before self-admin	0.2	0.2	0.5	-0.7	-0.5	-0.6	0.1	-0.1
Time to tail flick, test, after self-admin	1.4	1.4	2.2	-1.2	-1.3	-0.6	1.5	1.2
Delta time to tail flick, vehicle, before/after SA	2.2	2.1	2.7	1.6	1.7	1.7	-1.3	-0.9
Delta time to tail flick, test, before/after SA	0.2	0.2	0.4	-0.3	-0.4	-0.3	0.5	0.6
Tibia length	6.2	17.5	27.6	-5.3	-5.0	-4.9	2.8	1.8
Ambulatory time before self-admin	0.8	0.8	1.3	-1.1	-1.1	-1.1	0.5	0.1
Ambulatory time after self-admin	0.7	0.7	1.3	-1.1	-0.9	-1.1	-0.3	-0.2
Bone: tissue strength	0.7	0.7	1.5	-0.4	-0.4	-0.1	1.2	1.2
Total heroin consumption	0.1	0.2	0.4	0.3	0.4	-0.1	-0.3	-0.6
Bone: trabecular number	0.2	0.2	0.9	-0.1	-0.2	0.2	0.5	0.9
Bone: trabecular spacing	0.8	1.0	2.0	0.8	1.0	0.4	-1.1	-1.4
Bone: trabecular thickness	1.6	1.9	2.8	-1.7	-1.6	-1.4	1.0	1.0
Bone: trabecular tissue density	0.2	0.3	0.7	-0.4	-0.4	-0.1	0.8	0.6
Water consumed over 24 hours	0.4	0.4	0.9	-0.2	-0.0	-0.6	-1.0	-1.0
Number of responses in last shaping day	1.2	1.3	1.6	1.1	1.2	1.1	-1.3	-1.0