Hub : Genes

Ndufb11b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	Ndufb11b	0.06	0.04	7.1e-03	0.05	0.03	0.04	0.05	3.1e-03	1.6e-02	5.1e-03	4.1e-03
2	LHb	gene expression	Ndufb11b	0.16	0.09	2.2e-03	0.09	0.08	0.08	0.06	3.1e-03	5.9e-03	6.6e-03	1.5e-02
3	NAcc	gene expression	Ndufb11b	0.02	0.02	4.8e-03	0.01	0.01	0.01	0.01	6.7e-03	1.7e-02	3.4e-02	4.6e-02
4	Adipose	gene expression	Ndufb11b	0.09	0.04	7.8e-11	0.06	0.08	0.07	0.07	1.3e-07	6.0e-09	1.7e-08	3.6e-08
5	Brain	gene expression	Ndufb11b	0.12	0.08	2.0e-06	0.04	0.06	0.05	0.07	3.0e-04	2.0e-06	1.4e-05	4.7e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.3	0.5	0.8	-0.6	-0.8	-0.7	0.9	0.5
Area under the delay curve	0.3	0.3	0.9	-0.9	-0.4	-0.5	0.1	0.4
BMI with tail	1.3	4.1	5.8	2.2	2.4	2.2	-1.0	-2.0
BMI without tail	0.0	0.1	0.2	0.3	0.3	0.0	0.4	0.2
Body weight	1.6	6.7	7.9	2.8	2.6	2.5	-2.1	-2.8
Weight adjusted by age	0.3	0.3	0.9	0.4	-0.1	0.4	-0.9	-0.7
Bone surface	0.1	0.1	0.3	0.2	-0.6	-0.2	-0.2	-0.4
Bone volume	0.0	0.0	0.1	0.1	-0.3	-0.0	-0.1	-0.1
Breakpoint value in progressive ratio session	0.1	0.2	0.7	-0.1	-0.1	-0.1	0.8	0.0
Number of licking bursts	0.2	0.3	0.6	-0.5	-0.7	-0.8	0.2	0.0
Context. condit. distance diff. score	6.2	7.5	10.6	2.9	2.8	3.3	-2.8	-1.7
Locomotion velocity, session 1	0.4	0.4	1.4	0.4	-0.3	0.1	-1.2	-0.8
Locomotion distance, session 1	1.8	2.2	4.0	-1.7	-2.0	-1.8	0.4	1.0
Locomotion velocity, session 2	0.3	0.3	0.5	0.6	0.4	0.6	-0.7	-0.6
Locomotion distance, session 2	2.1	2.9	4.0	-1.8	-2.0	-1.9	1.8	0.8
Locomotion velocity, session 3	0.3	0.3	1.5	0.2	0.1	0.2	-1.2	0.0
Locomotion distance, session 3	1.2	1.3	1.7	-1.3	-1.2	-1.3	-0.3	1.2
Stereotopy head waving bouts, day 3	1.1	1.3	1.5	1.2	1.2	1.1	-0.9	-1.2
Stereotopy head waving duration, day 3	3.7	4.4	5.4	2.3	2.1	2.2	-1.8	-2.0
Locomotion velocity, session 7	0.2	0.2	0.7	-0.4	0.5	-0.1	-0.8	0.3
Locomotion distance, session 7	0.4	0.5	1.5	-1.2	0.1	-0.8	0.2	0.7
Stereotopy head waving bouts, day 7	3.3	3.7	5.5	2.1	1.6	2.0	-2.3	-1.5
Stereotopy head waving duration, day 7	2.0	2.5	3.6	1.7	1.5	1.7	-1.9	-0.9
Locomotion velocity, session 8	3.4	4.1	5.8	2.3	1.3	2.4	-1.6	-2.2
Locomotion distance, session 8	0.7	1.1	2.2	1.1	0.6	1.5	-1.2	-0.5
Degree of sensitization distance	1.6	1.6	3.4	1.2	1.9	1.5	-0.1	-1.1
Degree of sensitization stereotypy	2.2	2.4	4.5	1.6	1.2	1.5	-2.1	-1.0
Conditioned locomotion	0.6	0.7	1.4	0.6	0.9	0.9	-1.2	-0.2
Cocaine response after cond. corrected	0.0	0.1	0.1	0.3	0.0	0.0	-0.4	-0.1
Cocaine response after cond. not corrected	0.0	0.0	0.1	0.3	-0.2	0.1	-0.2	0.1
Cocaine response before conditioning	0.2	0.2	0.4	-0.4	-0.5	-0.2	0.5	0.6
Saline control response	0.2	0.2	0.4	0.7	-0.1	0.5	-0.6	0.4
Bone: connectivity density	0.1	0.1	0.3	-0.2	-0.3	-0.4	0.5	0.1
Bone: cortical apparent density	0.5	0.7	1.2	-1.1	-0.6	-1.1	0.6	0.5
Bone: cortical area	1.5	2.2	2.8	1.6	1.4	1.5	-1.3	-1.7
Bone: cortical porosity	0.2	0.2	0.4	0.4	0.6	0.6	-0.3	-0.1
Bone: cortical porosity	0.8	0.9	1.2	1.0	1.0	1.1	-0.8	-0.7
Bone: cortical thickness	0.2	0.3	0.9	0.2	0.7	0.2	0.2	-0.9
Bone: cortical thickness	0.5	0.6	1.5	0.6	0.8	0.6	-0.1	-1.2
Bone: cortical tissue density	0.5	0.6	1.1	-1.1	-0.6	-1.1	0.6	0.5
Condit. Reinf. active minus inactive responses	0.3	0.3	0.8	-0.9	-0.4	-0.5	0.5	0.1
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.3	0.3	0.5	0.4	-0.6	-0.4
Condit. Reinf. active responses	1.8	2.2	2.9	-1.7	-1.4	-1.4	1.6	1.3
Condit. Reinf. inactive responses	3.4	4.0	4.6	-2.0	-1.9	-1.9	2.1	2.1
Incentive salience index mean	0.7	0.9	1.9	-1.4	-0.7	-0.9	1.0	0.5
Condit. Reinf. lever presses	1.1	1.4	2.7	-1.6	-0.9	-1.1	1.2	1.0
Condit. Reinf. active minus inactive responses	0.2	0.2	0.9	0.0	0.3	0.2	0.1	-0.9
Condit. Reinf. active-inactive response ratio	0.3	0.3	1.3	0.1	0.4	0.2	0.3	-1.2
Condit. Reinf. active responses	0.8	1.1	2.1	0.9	0.9	1.0	-0.9	-1.5
Condit. Reinf. inactive responses	1.2	1.5	2.5	1.0	1.1	1.2	-1.6	-1.1
Condit. Reinf. lever presses	0.1	0.2	0.6	-0.3	-0.5	-0.1	0.8	-0.1
Condit. Reinf. lever reinforcers received	0.4	0.6	1.3	0.5	0.7	0.7	-0.5	-1.1
Conditioned reinforcement - actives	0.8	0.8	1.6	0.5	1.2	0.5	-1.3	-0.6
Conditioned reinforcement - inactives	0.1	0.1	0.3	-0.0	0.1	-0.3	0.6	-0.3
Conditioned locomotion	2.2	2.7	3.8	1.3	2.0	1.4	-1.4	-1.9
Patch foraging indifference point 0 sec	0.4	0.6	1.9	-0.3	-0.8	-0.6	1.4	0.2
Patch foraging indifference point AUC	0.1	0.1	0.2	-0.1	-0.3	-0.5	-0.4	-0.4
Delay disc. indifference point, 0s delay	0.4	0.4	1.2	0.5	0.7	1.1	-0.2	-0.2
Delay disc. indifference point, 16s delay	1.4	1.4	2.1	-1.4	-1.3	-1.4	0.8	0.9
Delay disc. indifference point, 2s delay	0.1	0.1	0.2	-0.3	0.4	0.3	-0.4	0.0
Delay disc. indifference point, 24s delay	0.5	0.5	1.1	-0.7	-0.1	-0.7	-1.0	-0.6
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	0.0	-0.0	0.3	0.4	-0.5
Delay disc. indifference point, 8s delay	1.1	1.2	2.5	-1.6	-0.6	-1.2	0.5	1.1
Indifference point function ln k	0.9	1.3	2.2	1.3	1.2	1.5	-0.7	-0.7
Indifference point function log k	0.9	1.3	2.2	1.3	1.2	1.5	-0.7	-0.7
Patch foraging total patch changes 0 sec	0.5	0.8	2.2	-0.4	-0.9	-0.7	1.5	0.3
Patch foraging total patch changes 12 sec	0.0	0.1	0.2	0.1	-0.0	-0.0	0.2	-0.4
Patch foraging total patch changes 18 sec	0.1	0.1	0.5	0.1	-0.0	-0.1	0.7	-0.3
Patch foraging total patch changes 24 sec	0.2	0.3	0.5	-0.4	-0.6	-0.7	0.4	0.3
Patch foraging total patch changes 6 sec	0.3	0.4	0.7	0.3	-0.8	-0.1	0.7	-0.9
Patch foraging time to switch 0 sec	0.4	0.6	1.3	-1.1	-0.2	-0.4	0.5	1.2
Patch foraging water rate 0 sec	0.3	0.5	1.1	1.1	-0.4	0.2	0.7	-0.9
Patch foraging water rate 12 sec	0.2	0.3	0.6	0.2	-0.8	-0.6	0.7	0.3
Patch foraging water rate 18 sec	0.9	1.2	3.7	-0.6	-1.9	-1.0	1.1	0.1
Patch foraging water rate 24 sec	0.3	0.4	1.1	1.0	0.1	0.3	0.4	-0.7
Patch foraging water rate 6 sec	0.4	0.6	1.5	-0.3	-1.2	-0.9	0.4	0.7
Seeking ratio, delayed vs. immediate footshock	3.7	4.3	5.5	-2.3	-1.6	-2.3	2.2	1.7
Distance traveled before self-admin	0.3	0.3	0.9	-0.6	0.2	0.1	0.9	0.5
Distance traveled after self-admin	0.5	0.5	1.8	0.8	0.3	0.1	0.4	-1.3
Extensor digitorum longus weight	0.2	0.8	1.5	-0.4	-1.2	-0.9	1.0	0.7
Bone: elastic displacement	0.3	0.4	0.6	0.8	-0.0	0.4	-0.8	-0.6
Bone: elastic work	2.3	3.0	4.2	2.0	1.5	2.0	-1.1	-1.9
Bone: endosteal estimation	1.2	2.7	4.2	2.0	0.9	1.8	-2.0	-1.2
Bone: endosteal perimeter	1.9	3.9	6.8	2.1	1.6	2.1	-2.6	-1.3
Epididymis fat weight	2.9	6.6	9.7	2.3	2.9	2.7	-3.1	-1.5
Delta time in closed arm before/after self-admin	1.5	1.4	1.8	0.9	1.3	1.4	-1.1	-1.3
Delta time in open arm before/after self-admin	0.4	0.4	1.5	-0.3	-0.1	-0.1	0.3	1.2
Diff in mean of infusions in LGA sessions	0.3	0.3	0.7	-0.5	-0.8	-0.5	0.3	-0.3
Delay discount exponential model param	0.3	0.3	0.9	1.0	0.4	0.6	-0.0	-0.4
Extinction: sum of active levers before priming	0.0	0.0	0.0	-0.2	0.0	0.1	0.1	-0.1
Active lever presses in extinction session 6	0.2	0.2	0.5	0.3	0.3	0.7	0.1	-0.4
Bone: final force	1.5	2.5	4.6	1.5	1.6	1.5	-0.9	-2.1
Bone: final moment	1.9	3.1	5.7	1.8	1.7	1.7	-1.0	-2.4
Food consumed during 24 hour testing period	1.5	1.8	2.9	1.3	1.4	1.2	-0.9	-1.7
Glucose	0.6	0.9	1.7	-0.8	-0.8	-0.6	1.3	0.9
Heart weight	2.6	3.7	5.8	2.4	2.1	2.2	-0.4	-1.8
Delay discount hyperbolic model param	0.2	0.2	0.6	0.7	0.2	0.4	0.1	-0.3
Intermittent access intake day 1-15 change	0.4	0.4	0.8	-0.6	-0.4	-0.9	0.5	0.5
Intermittent access intake escalation	0.5	0.4	0.8	-0.6	-0.5	-0.9	0.7	0.6
Intermittent access intake escalation 2	0.2	0.2	0.2	-0.3	-0.4	-0.5	0.4	0.5
Intermitt. access day 1 inactive lever presses	0.9	0.9	1.4	1.2	0.7	1.1	0.5	-1.2
Intermitt. access day 15 inactive lever presses	0.9	1.0	1.7	1.1	1.1	1.0	0.2	-1.3
Intermitt. access escalation Index	0.1	0.1	0.2	0.1	-0.0	-0.2	0.5	-0.5
Intermittent access day 1 total infusions	1.0	1.2	2.3	1.1	1.5	0.9	-0.8	-1.0
Intermittent access day 15 total infusions	0.1	0.1	0.3	0.1	0.5	-0.3	0.2	-0.3
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.3	0.1	0.5	-0.1	-0.3	-0.1
Intermittent access total infusions	0.3	0.3	0.9	0.4	1.0	0.3	-0.3	-0.6
Intermittent access day 1 locomotion	0.4	0.4	1.1	0.6	1.1	0.7	-0.2	-0.5
Intermittent access day 15 total locomotion	0.1	0.1	0.4	0.2	0.7	-0.0	-0.3	-0.3
Intermittent access total locomotion	0.4	0.4	1.0	0.5	1.0	0.4	-0.3	-0.7
Intermittent access standard deviation	0.4	0.4	1.3	0.7	1.1	0.5	0.0	-0.5
Left kidney weight	13.3	37.4	42.6	6.5	6.0	6.2	-5.5	-6.2
Right kidney weight	14.6	41.0	46.5	6.8	6.3	6.7	-5.6	-6.6
Cocaine induced anxiety	0.3	0.4	0.7	0.7	0.8	0.4	0.1	-0.8
Post-drug Anxiety	0.2	0.2	0.7	0.5	0.3	0.1	0.2	-0.8
Baseline Anxiety	0.8	0.8	1.4	-0.9	-1.2	-0.9	0.4	1.0
Tail length	0.2	0.5	0.7	-0.5	-0.8	-0.8	0.4	0.8
Length with tail	0.4	1.6	2.3	1.4	0.8	1.1	-1.5	-1.5
Length without tail	1.5	3.3	5.4	1.7	1.4	1.6	-1.9	-2.3
Times rat made contact with spout	1.1	1.2	2.6	1.2	0.8	0.9	-0.8	-1.6
Lifetime Intake	0.8	0.9	2.1	0.8	1.5	0.8	-0.4	-1.1
Liver weight, left	0.7	1.1	2.6	1.0	1.1	0.9	-1.6	-0.4
Liver weight, right	1.9	3.1	6.5	1.4	1.9	1.8	-2.5	-0.5
Locomotor activity	1.9	3.0	3.9	2.0	1.8	1.6	-1.6	-1.6
Locomotor testing distance	0.0	0.1	0.2	-0.2	0.1	-0.5	-0.0	0.1
Locomotor testing rearing	1.4	2.1	3.6	1.4	1.9	1.3	-1.5	-1.0
Locomotion in novel chamber	0.5	0.6	2.1	-0.6	-0.2	-0.6	-0.1	1.4
Locomotion in novel chamber post-restriction	1.4	1.7	2.9	-1.7	-1.0	-1.2	0.7	1.6
Fecal boli incidents, locomotor time 1	0.2	0.2	0.4	-0.5	-0.6	-0.4	0.5	0.2
Change in fecal boli incidents, locomotor task	1.1	1.1	2.7	0.7	0.8	0.3	-1.6	-1.1
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.1	-0.0	0.0	0.1	-0.2	-0.4
Bouts of movement, locomotor time 1	0.1	0.1	0.4	-0.1	0.4	-0.1	-0.7	-0.2
Total resting periods, locomotor time 1	0.1	0.1	0.3	-0.5	0.2	-0.3	-0.1	-0.1
Rest time, locomotor task time 1	0.1	0.1	0.4	-0.1	0.6	0.1	0.2	-0.4
Distance moved, locomotor task time 1	0.6	0.6	1.1	0.7	0.8	1.1	-0.9	-0.2
Vertical activity count, locomotor time 1	0.0	0.0	0.0	0.2	0.1	0.0	0.1	0.1
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.4	-0.4	-0.6	-0.4	0.2	-0.1
Bouts of movement, locomotor time 2	0.2	0.3	0.9	0.3	0.9	0.4	0.2	-0.4
Total resting periods, locomotor time 2	0.2	0.2	0.7	0.3	0.8	0.4	0.2	-0.5
Rest time, locomotor task time 2	0.1	0.1	0.2	-0.3	-0.3	-0.4	0.2	-0.1
Distance moved, locomotor task time 2	0.5	0.6	0.9	0.5	1.0	1.0	-0.9	-0.2
Vertical activity count, locomotor time 2	0.2	0.3	0.3	0.6	0.4	0.5	-0.6	-0.4
Light reinforcement 1	0.1	0.2	0.6	0.4	0.4	0.2	-0.8	-0.4
Light reinforcement 2	0.3	0.4	0.8	0.5	0.8	0.3	-0.9	-0.1
Bone: marrow area	1.4	3.0	4.7	2.2	0.9	1.9	-2.0	-1.3
Bone: maximum diameter	4.5	8.4	10.1	3.2	2.7	3.0	-2.6	-3.0
Bone: maximum force	2.9	5.1	7.5	2.3	2.2	2.3	-1.5	-2.7
Bone: maximum moment	3.5	6.0	8.8	2.6	2.4	2.5	-1.6	-3.0
Mean time between licks in bursts	0.7	1.0	1.3	-1.1	-1.0	-1.0	1.0	0.9
Mean num. licks in bursts	1.7	2.1	2.7	1.5	1.5	1.6	-1.2	-1.3
Cd content in liver	1.2	1.3	2.0	1.4	0.9	1.4	-1.1	-0.8
Co content in liver	0.5	0.6	1.1	1.0	0.5	0.7	-0.3	-1.0
Cu content in liver	4.3	5.2	6.2	-2.5	-2.4	-2.1	2.2	2.1
Fe content in liver	0.1	0.1	0.6	0.8	0.0	0.2	0.1	-0.1
K content in liver	0.5	0.5	1.1	-0.5	-0.9	-0.4	1.0	0.0
Mg content in liver	1.2	1.2	2.8	-1.1	-1.2	-0.8	1.7	0.4
Mn content in liver	0.3	0.4	0.9	-0.0	0.3	0.9	-1.0	-0.2
Na content in liver	3.0	3.2	3.6	-1.8	-1.9	-1.6	1.8	1.8
Rb content in liver	0.0	0.0	0.1	0.0	0.1	0.1	0.1	-0.4
Se content in liver	0.6	0.7	1.1	-0.8	-0.9	-0.9	0.5	1.0
Sr content in liver	1.2	1.1	1.6	-1.2	-0.8	-1.1	0.6	1.3
Zn content in liver	1.0	1.1	2.1	-1.0	-1.4	-0.9	0.8	0.9
Bone: minimum diameter	0.5	1.0	1.7	1.1	0.9	1.0	-1.3	-0.6
Time in familiar zone, hab. session 1	0.3	0.2	0.8	-0.2	0.1	0.0	-0.9	-0.6
Time in novel zone, hab. session 1	1.0	0.9	2.5	1.6	0.7	1.2	-0.1	-0.4
Total zone transitions, hab. session 1	2.5	3.5	5.8	-2.0	-2.4	-2.2	0.7	1.6
Total locomotion distance, hab. session 1	1.2	1.6	3.2	-1.2	-1.8	-1.3	-0.1	1.4
Locomotion velocity, hab. session 1	1.6	2.3	4.4	-1.5	-2.1	-1.5	0.3	1.5
Time in familiar zone, hab. session 2	0.3	0.3	0.8	-0.4	-0.3	-0.3	-0.7	0.9
Time in novel zone, hab. session 2	0.7	0.7	1.5	1.2	0.3	0.8	0.4	-1.2
Total zone transitions, hab. session 2	0.4	0.5	1.3	-0.6	-1.1	-0.6	0.5	-0.2
Total locomotion distance, hab. session 2	0.4	0.5	1.1	-0.7	-1.0	-0.6	0.8	0.4
Locomotion velocity, hab. session 2	0.9	1.2	2.0	-1.1	-1.4	-1.1	1.0	0.7
Novel to familiar place preference ratio	4.1	4.3	7.5	2.7	1.6	2.2	-1.7	-1.9
Novelty place preference	5.4	5.5	9.2	3.0	1.9	2.4	-2.1	-2.1
Time in novel zone, NPP test	6.6	6.8	11.1	3.3	2.1	2.7	-2.3	-2.3
Total zone transitions, NPP test	1.7	2.4	5.3	-1.6	-2.3	-1.6	0.6	1.1
Total locomotion distance, NPP test	0.8	1.1	2.4	-1.1	-1.5	-1.1	0.7	0.7
Locomotion velocity, NPP test	1.9	2.6	3.9	-1.9	-2.0	-1.7	1.0	1.4
Intraocular pressure	0.3	0.4	1.2	0.1	0.8	0.6	-1.1	-0.1
Delta distance traveled before/after self-admin	1.8	1.9	4.2	1.7	0.5	0.6	-1.4	-2.1
Delta ambulatory time before/after self-admin	2.3	2.5	6.0	2.0	0.4	0.8	-1.4	-2.5
Parametrial fat weight	0.1	0.1	0.3	0.1	0.6	0.5	-0.1	-0.2
Pavlov. Cond. lever latency	1.3	1.7	2.5	1.6	1.0	1.4	-1.3	-1.1
Pavlov. Cond. magazine entry latency	1.0	1.3	2.1	-1.5	-0.8	-1.3	1.2	0.5
Pavlov. Cond. change in total contacts	1.1	1.2	2.0	-1.3	-0.8	-1.2	1.4	0.2
Pavlov. Cond. index score	0.5	0.7	1.3	-1.1	-0.3	-1.0	1.0	0.2
Pavlov. Cond. latency score	0.5	0.6	1.1	-1.0	-0.3	-0.9	1.1	0.3
Pavlov. Cond. lever contacts	1.7	2.0	3.0	-1.7	-1.0	-1.5	1.5	1.2
Pavlov. Cond. magazine entry number	0.7	0.8	1.6	1.3	0.5	1.1	-0.9	-0.3
Pavlov. Cond. intertrial magazine entries	0.7	0.8	1.3	-0.7	-1.0	-1.0	1.2	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	2.0	-1.4	-0.5	-1.2	1.1	0.5
Pavlov. Cond. response bias	1.2	1.5	2.9	-1.7	-0.7	-1.4	1.3	0.7
Pavlov. Cond. lever latency	0.7	1.0	2.6	0.7	1.2	0.5	-1.6	-0.2
Pavlov. Cond. magazine entry latency	3.4	3.9	8.0	-1.7	-2.0	-1.9	2.8	0.9
Pavlov. Cond. change in total contacts	0.7	1.0	3.5	-0.1	-0.7	-0.1	1.9	-1.0
Pavlov. Cond. index score	2.0	2.5	6.0	-1.3	-1.7	-1.3	2.4	0.5
Pavlov. Cond. latency score	2.5	3.1	7.0	-1.5	-1.9	-1.5	2.7	0.5
Pavlov. Cond. lever contacts	0.8	1.0	3.0	-0.7	-1.2	-0.5	1.7	0.3
Pavlov. Cond. magazine entry number	1.6	2.0	4.7	1.2	1.3	1.3	-2.2	-0.5
Pavlov. Cond. intertrial magazine entries	2.6	3.4	4.9	1.7	2.2	2.0	-1.5	-1.7
Pavlov. Cond. lever-magazine prob. diff.	2.1	2.7	6.0	-1.4	-1.7	-1.4	2.5	0.7
Pavlov. Cond. response bias	0.9	1.2	3.7	-0.9	-1.1	-0.7	1.9	0.1
Time in closed arm before self-admin	6.3	7.1	9.7	-2.3	-2.8	-2.8	3.1	2.2
Time in closed arm after self-admin	0.2	0.2	0.2	0.4	0.4	0.4	-0.3	-0.5
Time in open arm before self-admin	0.2	0.2	0.9	-0.0	-0.0	0.1	-1.0	0.2
Time in open arm after self-admin	0.5	0.6	2.3	-0.6	-0.4	-0.3	0.0	1.5
Bone: periosteal estimation	1.8	3.8	5.3	2.3	1.5	2.0	-2.1	-1.8
Bone: periosteal perimeter	3.5	5.8	7.5	2.4	2.4	2.5	-2.7	-1.9
Bone: post-yield work	0.5	0.7	1.6	0.8	0.7	0.9	-0.2	-1.3
Progressive ratio test 1 active lever presses	0.4	0.4	1.1	0.4	1.0	0.4	-0.3	-0.8
Progressive ratio test 1 breakpoint	0.2	0.2	0.7	0.3	0.8	0.2	-0.4	-0.5
Progressive ratio test 1 inactive lever presses	0.4	0.5	0.9	0.4	1.0	0.7	0.8	-0.4
Progressive ratio test 2 active lever presses	0.1	0.1	0.1	-0.2	0.3	-0.3	0.1	-0.3
Progressive ratio test 2 breakpoint	0.1	0.1	0.3	0.1	0.5	-0.1	0.1	-0.6
Progressive ratio test 2 inactive lever presses	0.4	0.4	1.5	-0.5	-0.0	-0.5	1.2	0.3
Incentive Sensitization - Responses	0.1	0.1	0.4	-0.3	-0.2	-0.4	0.6	-0.1
Incentive Sensitization - Breakpoint	0.1	0.1	0.2	-0.2	-0.0	-0.2	0.5	-0.3
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	-0.3	-0.1	0.4	0.5	0.3
Progressive ratio	0.2	0.3	0.7	-0.1	-0.7	-0.3	0.8	0.3
Food seeking constrained by brief footshock	1.5	1.8	3.6	1.1	1.9	0.7	-1.3	-1.3
Seeking ratio, punishment vs. effort	0.9	1.1	2.5	0.6	1.6	0.6	-1.1	-1.0
Retroperitoneal fat weight	3.3	11.0	13.2	3.0	3.6	3.5	-3.5	-3.0
Reaction time number correct	0.9	1.3	2.3	-1.2	-1.2	-1.5	0.1	1.2
Reaction time mean minus median	0.2	0.2	0.4	0.6	0.6	0.5	-0.3	0.1
Reaction time mean minus median AUC	0.6	0.7	1.7	0.8	1.3	1.0	-0.7	-0.1
Reaction time num false alarms	0.1	0.2	0.5	0.0	-0.4	-0.2	-0.4	0.7
Reaction time num false alarms AUC	0.2	0.2	0.6	-0.0	-0.6	-0.3	-0.4	0.8
Reaction time trials correct on left	0.9	1.3	2.3	-1.2	-1.2	-1.5	0.1	1.2
Reaction time trials on left	1.0	1.4	2.4	-1.3	-1.2	-1.5	0.1	1.3
Reaction time mean	0.2	0.2	0.5	-0.2	-0.3	-0.4	0.7	0.6
Reaction time mean AUC	0.1	0.2	0.4	-0.3	-0.2	-0.4	0.6	0.6
Median of all reaction times	0.4	0.5	1.0	-0.6	-0.6	-0.7	1.0	0.7
Reaction time omissions	0.2	0.2	0.5	-0.4	-0.5	-0.3	0.1	0.7
Reaction time false alarm rate	0.1	0.1	0.2	0.5	0.1	0.4	-0.2	0.2
Reaction time premature initiation rate	0.4	0.5	1.0	-0.1	-0.8	-0.8	1.0	-0.6
Reaction time premature initiations	0.5	0.7	1.5	-0.5	-1.0	-1.2	0.8	-0.1
Std. dev. reaction times	0.3	0.4	0.7	0.8	0.9	0.7	-0.5	-0.2
Reaction time trials completed	1.0	1.4	2.4	-1.3	-1.2	-1.5	0.1	1.3
Reaction time trials AUC	0.7	1.1	1.8	-1.1	-1.1	-1.3	0.0	1.1
Run reversals in cocaine runway, females	0.8	0.7	1.5	-0.7	-1.2	-1.0	-0.2	0.8
Run reversals in cocaine runway, males	1.3	1.3	2.8	1.0	1.1	0.7	-1.7	-0.8
Latency to leave start box in cocaine runway	0.1	0.1	0.3	0.3	0.6	0.2	-0.2	0.0
Latency to leave start box in cocaine runway, F	0.3	0.3	0.5	-0.4	-0.5	-0.7	0.5	0.7
Latency to leave start box in cocaine runway, M	1.4	1.4	3.0	1.0	1.7	1.2	-0.8	-0.9
Std. dev. time between licks in bursts	1.1	1.3	2.3	-1.1	-1.3	-1.1	1.5	0.3
Total sessions with >9 infusions	2.1	2.3	4.0	1.2	1.8	1.4	-1.0	-2.0
Short access day 1 total inactive lever presses	2.0	2.3	3.2	1.7	1.6	1.6	-0.6	-1.8
Short access day 10 total inactive lever presses	0.7	0.7	1.2	1.1	1.0	0.8	-0.6	-0.8
Short access day 1 total infusions	2.1	2.3	3.4	1.5	1.8	1.6	-0.7	-1.7
Short access day 10 total infusions	0.5	0.6	1.4	0.5	1.2	0.6	-0.3	-0.9
Short access total infusions	2.3	2.6	4.8	1.4	2.2	1.7	-0.7	-1.8
Short access day 1 locomotion	0.1	0.1	0.2	0.2	0.4	0.4	0.3	-0.2
Short access day 10 total locomotion	0.3	0.4	0.8	-0.5	0.4	0.0	0.8	0.9
Short access total locomotion	0.9	0.9	2.4	0.6	1.5	1.1	-0.2	-0.9
One hour access (0.3 mA shock)	0.6	0.7	1.4	-0.9	-0.0	-1.2	0.4	1.0
Compulsive drug intake	1.4	1.4	2.4	-1.3	-1.4	-1.5	0.7	0.8
One hour access (shock baseline)	0.1	0.2	0.4	-0.2	0.7	-0.3	-0.0	0.5
Social response proportion	0.4	0.4	0.9	0.5	0.5	0.7	1.0	-0.2
Social responses	0.0	0.0	0.1	0.1	-0.1	-0.3	-0.2	-0.2
Social time	1.8	2.4	3.0	-1.7	-1.4	-1.5	1.6	1.4
Soleus weight	0.1	0.3	0.7	-0.1	-0.8	0.2	0.3	-0.7
Bone: stiffness	1.4	2.3	3.3	1.4	1.8	1.5	-0.8	-1.7
Tibialis anterior weight	0.7	2.3	3.5	-1.2	-1.7	-1.7	1.9	0.8
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.5	0.4	-0.2	0.7	-0.6	-0.5
Time to tail flick, vehicle, after self-admin	1.0	1.1	1.8	-0.8	-1.2	-1.2	-0.0	1.3
Time to tail flick, test, before self-admin	0.3	0.3	1.1	-0.3	-0.2	-0.2	-1.1	0.3
Time to tail flick, test, after self-admin	1.5	1.6	2.3	-1.5	-1.4	-1.2	0.8	1.2
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.8	-0.5	-0.3	-0.9	0.7	0.7
Delta time to tail flick, test, before/after SA	2.2	1.9	2.8	-1.1	-1.7	-1.2	1.7	1.1
Tibia length	1.1	3.1	5.1	1.7	1.5	1.6	-1.7	-2.3
Ambulatory time before self-admin	0.2	0.2	0.6	-0.5	0.2	-0.0	0.8	0.6
Ambulatory time after self-admin	0.3	0.3	0.6	0.3	-0.6	-0.6	0.5	-0.8
Bone: tissue strength	0.3	0.3	0.6	0.7	0.5	0.3	-0.3	-0.8
Total heroin consumption	0.2	0.2	0.6	0.1	0.3	0.6	-0.1	-0.8
Bone: trabecular number	0.1	0.1	0.2	-0.2	0.1	-0.3	-0.4	0.5
Bone: trabecular spacing	1.1	1.4	2.5	0.9	1.2	1.2	-0.9	-1.6
Bone: trabecular thickness	0.4	0.5	1.1	-0.5	-0.5	-0.4	0.8	1.1
Bone: trabecular tissue density	1.3	1.9	4.4	-0.8	-1.5	-1.2	2.1	0.7
Water consumed over 24 hours	1.3	1.6	2.8	1.5	0.8	1.0	-1.0	-1.7
Number of responses in last shaping day	1.0	1.0	3.0	-0.9	-0.8	-0.7	1.7	0.4