Hub : Genes

Ndufa6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	LHb	mRNA stability	Ndufa6	0.17	0.1	8.6e-03	-0.01	-0	-0.01	-0.01	8.6e-01	3.9e-01	9.7e-01	7.6e-01
2	NAcc	mRNA stability	Ndufa6	0.06	0.04	3.9e-03	-0	0	-0	-0	9.7e-01	1.9e-01	8.7e-01	7.5e-01
3	NAcc	gene expression	Ndufa6	0.04	0.03	3.2e-03	0.03	0.02	0.02	0.03	2.5e-04	1.8e-03	3.1e-03	5.4e-04
4	Brain	gene expression	Ndufa6	0.07	0.05	1.5e-03	0.04	0.03	0.04	0.04	7.7e-05	9.7e-04	1.5e-04	2.3e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.2	0.3	0.9	1.0	-0.5	0.2	0.2
Area under the delay curve	0.1	0.1	0.3	0.5	0.2	-0.1	-0.1
BMI with tail	0.6	2.1	4.9	-2.2	-0.5	1.3	1.2
BMI without tail	0.0	0.1	0.3	-0.5	0.1	0.0	0.0
Body weight	0.4	1.7	5.7	-2.4	0.2	0.8	0.6
Weight adjusted by age	0.6	0.7	1.0	-0.1	1.0	-0.9	-0.9
Bone surface	0.2	0.4	1.3	1.2	-0.3	0.1	0.1
Bone volume	0.1	0.1	0.5	0.7	-0.1	-0.0	0.0
Breakpoint value in progressive ratio session	0.4	0.5	1.0	0.1	-1.0	0.7	0.7
Number of licking bursts	0.1	0.1	0.2	0.3	0.0	-0.4	-0.3
Context. condit. distance diff. score	2.3	2.7	8.9	-3.0	1.4	0.2	0.0
Locomotion velocity, session 1	0.2	0.2	0.4	0.6	0.2	-0.3	-0.3
Locomotion distance, session 1	1.1	1.5	3.1	1.8	0.3	-1.2	-1.1
Locomotion velocity, session 2	0.0	0.0	0.1	0.2	0.0	0.1	0.1
Locomotion distance, session 2	1.4	1.9	4.6	2.1	-1.5	0.6	0.6
Locomotion velocity, session 3	0.5	0.6	0.9	0.3	0.9	-0.8	-0.9
Locomotion distance, session 3	1.8	2.0	2.8	0.8	1.3	-1.7	-1.6
Stereotopy head waving bouts, day 3	0.3	0.3	0.6	0.0	-0.5	0.7	0.8
Stereotopy head waving duration, day 3	0.4	0.5	1.1	-1.0	0.1	0.7	0.7
Locomotion velocity, session 7	0.4	0.4	0.8	0.1	0.9	-0.7	-0.7
Locomotion distance, session 7	0.1	0.2	0.6	0.8	-0.1	0.0	-0.1
Stereotopy head waving bouts, day 7	0.4	0.5	1.0	-0.9	1.0	-0.2	-0.1
Stereotopy head waving duration, day 7	0.6	0.7	1.6	-1.0	1.3	-0.5	-0.5
Locomotion velocity, session 8	1.2	1.4	3.6	-1.9	-0.4	1.0	0.9
Locomotion distance, session 8	0.3	0.4	1.1	-1.0	0.6	0.1	-0.1
Degree of sensitization distance	2.1	2.1	3.1	-1.1	-1.2	1.8	1.7
Degree of sensitization stereotypy	0.8	0.9	1.8	-1.0	1.4	-0.6	-0.5
Conditioned locomotion	1.1	1.3	2.3	-0.8	1.5	-1.0	-1.0
Cocaine response after cond. corrected	0.2	0.2	0.3	-0.2	0.5	-0.4	-0.5
Cocaine response after cond. not corrected	0.3	0.3	0.4	-0.1	0.6	-0.5	-0.7
Cocaine response before conditioning	0.0	0.0	0.1	0.3	0.1	-0.1	-0.2
Saline control response	0.5	0.7	1.1	-0.2	1.1	-0.9	-0.9
Bone: connectivity density	0.2	0.3	0.6	0.8	-0.6	0.4	0.5
Bone: cortical apparent density	0.3	0.3	1.2	1.1	-0.4	-0.0	-0.1
Bone: cortical area	0.5	0.8	1.8	-1.4	-0.1	0.8	0.9
Bone: cortical porosity	0.1	0.1	0.3	-0.5	0.3	-0.0	0.1
Bone: cortical porosity	0.2	0.2	0.7	-0.9	0.2	0.3	0.3
Bone: cortical thickness	1.0	1.7	2.3	-0.9	-1.2	1.5	1.5
Bone: cortical thickness	1.1	1.3	2.2	-1.5	-0.7	1.2	1.1
Bone: cortical tissue density	0.3	0.3	1.2	1.1	-0.4	0.0	-0.1
Condit. Reinf. active minus inactive responses	0.7	0.8	1.2	1.1	-0.9	0.8	0.7
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.2	0.2	-0.3	0.5	0.4
Condit. Reinf. active responses	0.7	0.8	2.6	1.6	-0.8	0.3	0.2
Condit. Reinf. inactive responses	0.6	0.7	2.4	1.5	-0.3	-0.4	-0.5
Incentive salience index mean	0.8	1.0	1.9	1.4	-1.0	0.7	0.6
Condit. Reinf. lever presses	0.6	0.7	2.7	1.6	-0.6	0.1	-0.0
Condit. Reinf. active minus inactive responses	1.6	2.0	2.9	0.4	-1.7	1.6	1.6
Condit. Reinf. active-inactive response ratio	3.1	3.2	4.7	0.6	-2.2	2.0	2.0
Condit. Reinf. active responses	0.7	1.0	1.5	-0.2	-1.0	1.2	1.2
Condit. Reinf. inactive responses	0.2	0.2	0.6	-0.8	0.6	-0.0	-0.0
Condit. Reinf. lever presses	1.2	1.6	2.2	1.1	-1.5	1.2	1.2
Condit. Reinf. lever reinforcers received	1.0	1.4	1.9	0.3	-1.3	1.4	1.3
Conditioned reinforcement - actives	0.2	0.2	0.5	-0.6	0.7	-0.1	-0.3
Conditioned reinforcement - inactives	0.6	0.7	1.1	-0.0	-0.9	0.9	1.1
Conditioned locomotion	0.8	1.0	1.9	-1.4	-0.1	1.0	1.1
Patch foraging indifference point 0 sec	0.7	1.2	2.1	0.9	-1.4	1.0	1.0
Patch foraging indifference point AUC	0.1	0.1	0.3	0.6	-0.3	0.2	-0.2
Delay disc. indifference point, 0s delay	0.2	0.3	0.8	-0.9	0.1	0.3	0.3
Delay disc. indifference point, 16s delay	0.6	0.6	1.9	1.4	-0.2	-0.4	-0.4
Delay disc. indifference point, 2s delay	0.1	0.1	0.3	-0.2	0.5	-0.1	-0.1
Delay disc. indifference point, 24s delay	0.3	0.3	0.4	0.5	0.6	-0.5	-0.5
Delay disc. indifference point, 4s delay	1.1	1.2	1.7	0.2	-1.1	1.3	1.3
Delay disc. indifference point, 8s delay	0.3	0.3	0.7	0.8	0.4	-0.4	-0.4
Indifference point function ln k	0.3	0.4	0.9	-1.0	0.1	0.3	0.6
Indifference point function log k	0.3	0.4	0.9	-1.0	0.1	0.3	0.6
Patch foraging total patch changes 0 sec	0.7	1.1	1.9	0.9	-1.4	0.9	0.9
Patch foraging total patch changes 12 sec	0.8	1.1	1.8	0.8	-1.3	1.1	0.9
Patch foraging total patch changes 18 sec	1.0	1.3	2.2	0.6	-1.5	1.3	0.9
Patch foraging total patch changes 24 sec	0.2	0.2	0.6	0.8	-0.5	0.1	-0.3
Patch foraging total patch changes 6 sec	0.9	1.4	2.3	0.4	-1.5	1.3	1.1
Patch foraging time to switch 0 sec	0.3	0.4	0.9	0.9	0.4	-0.6	-0.5
Patch foraging water rate 0 sec	0.7	1.2	1.6	-0.7	-1.2	1.3	1.0
Patch foraging water rate 12 sec	0.0	0.1	0.1	0.4	-0.4	0.1	0.0
Patch foraging water rate 18 sec	0.6	0.8	1.8	1.3	-1.1	0.2	0.2
Patch foraging water rate 24 sec	1.2	1.7	3.0	0.0	-1.7	1.3	1.4
Patch foraging water rate 6 sec	0.5	0.7	1.9	1.4	0.1	-0.6	-0.8
Seeking ratio, delayed vs. immediate footshock	1.2	1.4	4.5	2.1	-0.9	-0.0	-0.4
Distance traveled before self-admin	0.6	0.6	1.2	0.3	-1.1	0.8	0.8
Distance traveled after self-admin	1.3	1.4	2.1	-0.2	-1.3	1.4	1.4
Extensor digitorum longus weight	0.0	0.1	0.2	0.0	0.1	-0.4	-0.3
Bone: elastic displacement	0.1	0.2	0.2	-0.4	0.5	-0.4	-0.2
Bone: elastic work	1.0	1.3	2.3	-1.5	-0.4	1.1	1.3
Bone: endosteal estimation	0.2	0.5	1.2	-0.3	1.1	-0.6	-0.6
Bone: endosteal perimeter	0.9	1.8	3.8	-0.9	2.0	-1.1	-1.1
Epididymis fat weight	1.0	2.2	4.8	-2.2	1.8	-0.6	-0.6
Delta time in closed arm before/after self-admin	0.5	0.5	1.5	-1.2	0.2	0.5	0.5
Delta time in open arm before/after self-admin	0.6	0.6	0.9	0.4	0.6	-0.9	-0.9
Diff in mean of infusions in LGA sessions	0.1	0.1	0.4	0.6	-0.4	-0.1	-0.1
Delay discount exponential model param	0.1	0.1	0.3	-0.6	-0.2	0.1	0.1
Extinction: sum of active levers before priming	0.1	0.1	0.1	-0.3	-0.2	0.2	0.2
Active lever presses in extinction session 6	0.2	0.2	0.2	-0.4	-0.5	0.5	0.5
Bone: final force	1.8	2.9	4.3	-1.1	-1.3	2.1	2.0
Bone: final moment	2.1	3.3	4.9	-1.2	-1.4	2.2	2.2
Food consumed during 24 hour testing period	1.0	1.3	1.8	-1.3	-0.7	1.1	1.3
Glucose	0.2	0.3	1.0	1.0	-0.5	0.2	0.1
Heart weight	2.6	3.7	7.4	-2.7	-0.9	1.8	1.8
Delay discount hyperbolic model param	0.0	0.0	0.1	-0.4	-0.2	-0.0	-0.0
Intermittent access intake day 1-15 change	0.0	0.0	0.1	0.3	-0.2	-0.0	0.1
Intermittent access intake escalation	0.1	0.1	0.2	0.4	-0.3	0.0	0.1
Intermittent access intake escalation 2	0.0	0.0	0.0	0.1	0.1	-0.2	-0.0
Intermitt. access day 1 inactive lever presses	2.0	2.1	3.0	-0.7	-1.6	1.6	1.7
Intermitt. access day 15 inactive lever presses	3.6	4.0	5.8	-0.9	-2.1	2.2	2.4
Intermitt. access escalation Index	0.4	0.3	0.6	0.1	-0.7	0.6	0.8
Intermittent access day 1 total infusions	0.6	0.7	1.1	-0.8	-0.4	1.0	0.9
Intermittent access day 15 total infusions	0.5	0.5	0.8	-0.1	-0.8	0.9	0.9
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.0	-0.2	0.1	0.2	0.2
Intermittent access total infusions	0.2	0.2	0.4	-0.4	-0.3	0.7	0.5
Intermittent access day 1 locomotion	0.3	0.3	0.5	-0.4	-0.4	0.7	0.6
Intermittent access day 15 total locomotion	0.1	0.2	0.3	-0.2	-0.2	0.5	0.6
Intermittent access total locomotion	0.5	0.6	0.9	-0.4	-0.5	0.9	1.0
Intermittent access standard deviation	0.9	1.0	1.5	-0.8	-0.7	1.1	1.2
Left kidney weight	3.8	10.7	25.1	-5.0	-0.7	3.0	2.9
Right kidney weight	4.7	13.1	30.5	-5.5	-0.7	3.2	3.3
Cocaine induced anxiety	1.6	1.8	2.3	-0.8	-1.5	1.5	1.5
Post-drug Anxiety	0.8	0.9	1.4	-0.5	-1.2	1.0	1.0
Baseline Anxiety	1.3	1.4	2.0	0.9	0.9	-1.4	-1.4
Tail length	0.1	0.4	0.7	0.3	0.5	-0.8	-0.8
Length with tail	0.0	0.1	0.2	-0.4	0.2	0.0	-0.0
Length without tail	0.3	0.6	0.9	-0.3	-0.7	1.0	0.9
Times rat made contact with spout	0.7	0.8	1.9	-1.4	-0.3	0.7	0.8
Lifetime Intake	1.0	1.2	1.8	-0.8	-0.9	1.3	1.2
Liver weight, left	0.6	0.9	2.0	-0.2	1.4	-0.8	-0.9
Liver weight, right	1.8	2.9	5.2	-1.1	2.3	-1.6	-1.7
Locomotor activity	0.3	0.5	1.8	-1.3	0.1	0.4	0.3
Locomotor testing distance	0.0	0.1	0.2	0.4	-0.1	-0.1	-0.2
Locomotor testing rearing	0.4	0.7	1.8	-1.3	0.9	-0.1	-0.2
Locomotion in novel chamber	3.0	3.7	5.2	0.1	2.1	-2.3	-2.2
Locomotion in novel chamber post-restriction	1.1	1.3	1.8	1.3	0.6	-1.3	-1.1
Fecal boli incidents, locomotor time 1	0.1	0.1	0.3	0.6	-0.2	-0.0	-0.0
Change in fecal boli incidents, locomotor task	0.3	0.3	0.7	-0.5	0.8	-0.3	-0.3
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	0.4	-0.2	0.3	0.3
Bouts of movement, locomotor time 1	0.0	0.0	0.1	-0.1	0.3	-0.2	-0.2
Total resting periods, locomotor time 1	0.0	0.0	0.0	0.1	-0.1	-0.1	-0.1
Rest time, locomotor task time 1	0.2	0.2	0.2	-0.4	-0.4	0.4	0.4
Distance moved, locomotor task time 1	0.1	0.1	0.3	-0.3	0.6	0.1	0.1
Vertical activity count, locomotor time 1	0.2	0.3	0.5	0.2	-0.3	0.6	0.7
Time >=10cm from walls, locomotor time 2	0.3	0.3	0.5	0.5	0.4	-0.6	-0.7
Bouts of movement, locomotor time 2	0.2	0.3	0.4	-0.2	-0.6	0.5	0.6
Total resting periods, locomotor time 2	0.4	0.4	0.6	-0.2	-0.8	0.7	0.7
Rest time, locomotor task time 2	0.0	0.1	0.1	0.2	-0.3	0.2	0.1
Distance moved, locomotor task time 2	0.4	0.5	0.9	-1.0	0.9	-0.2	-0.2
Vertical activity count, locomotor time 2	0.2	0.2	0.5	-0.7	0.3	0.2	0.3
Light reinforcement 1	0.2	0.3	0.4	0.5	0.6	-0.6	-0.6
Light reinforcement 2	0.1	0.2	0.4	0.1	0.6	-0.3	-0.4
Bone: marrow area	0.2	0.4	1.0	-0.3	1.0	-0.5	-0.5
Bone: maximum diameter	0.9	1.7	4.8	-2.2	0.3	1.0	1.0
Bone: maximum force	1.9	3.3	4.4	-1.8	-1.1	2.1	2.1
Bone: maximum moment	2.2	3.8	5.1	-2.0	-1.2	2.2	2.3
Mean time between licks in bursts	0.2	0.3	0.5	0.1	0.4	-0.7	-0.6
Mean num. licks in bursts	0.7	0.8	2.3	-1.5	0.1	0.7	0.7
Cd content in liver	2.0	2.2	6.5	-2.5	1.3	-0.6	-0.4
Co content in liver	0.8	0.9	3.0	-1.7	-0.0	0.5	0.5
Cu content in liver	1.7	2.0	7.3	2.7	-0.5	-0.5	-0.5
Fe content in liver	0.1	0.1	0.2	0.5	-0.2	0.1	0.1
K content in liver	1.8	1.8	2.8	1.5	-1.7	1.1	1.0
Mg content in liver	3.2	3.2	4.7	2.1	-2.2	1.4	1.4
Mn content in liver	0.4	0.5	0.7	-0.0	0.8	-0.8	-0.7
Na content in liver	0.9	0.9	3.0	1.7	-0.4	-0.4	-0.5
Rb content in liver	0.5	0.6	0.9	0.5	-1.0	0.9	0.7
Se content in liver	0.7	0.9	2.1	1.4	0.2	-0.8	-0.9
Sr content in liver	0.8	0.7	1.0	-0.5	0.9	-1.0	-0.8
Zn content in liver	0.4	0.4	1.0	1.0	0.2	-0.7	-0.6
Bone: minimum diameter	0.1	0.2	0.6	-0.4	0.7	-0.2	-0.2
Time in familiar zone, hab. session 1	0.4	0.3	0.5	-0.0	0.6	-0.7	-0.7
Time in novel zone, hab. session 1	0.7	0.7	2.6	-1.6	0.4	0.3	0.2
Total zone transitions, hab. session 1	1.6	2.3	4.3	2.1	0.5	-1.5	-1.5
Total locomotion distance, hab. session 1	2.1	2.9	3.6	1.8	1.2	-1.9	-1.9
Locomotion velocity, hab. session 1	1.7	2.4	4.7	2.2	0.7	-1.5	-1.5
Time in familiar zone, hab. session 2	2.7	2.8	4.2	-0.4	2.0	-1.9	-1.8
Time in novel zone, hab. session 2	2.2	2.2	3.1	-0.4	-1.7	1.8	1.6
Total zone transitions, hab. session 2	0.5	0.7	1.8	1.3	-0.9	0.3	0.3
Total locomotion distance, hab. session 2	0.3	0.4	1.2	1.1	-0.5	-0.0	0.1
Locomotion velocity, hab. session 2	0.5	0.7	2.4	1.6	-0.5	-0.2	-0.1
Novel to familiar place preference ratio	1.5	1.5	5.4	-2.3	0.7	0.4	0.2
Novelty place preference	2.1	2.1	7.4	-2.7	1.0	0.3	0.1
Time in novel zone, NPP test	2.5	2.5	9.0	-3.0	1.0	0.4	0.2
Total zone transitions, NPP test	0.7	1.0	2.8	1.7	0.1	-1.0	-0.7
Total locomotion distance, NPP test	0.4	0.5	1.7	1.3	-0.3	-0.4	-0.1
Locomotion velocity, NPP test	0.8	1.1	3.2	1.8	0.1	-0.9	-0.6
Intraocular pressure	0.2	0.3	0.5	-0.7	0.7	-0.2	-0.3
Delta distance traveled before/after self-admin	0.2	0.2	0.6	-0.8	0.3	0.3	0.3
Delta ambulatory time before/after self-admin	0.4	0.4	0.7	-0.8	-0.1	0.7	0.7
Parametrial fat weight	0.1	0.2	0.4	-0.6	-0.0	0.4	0.3
Pavlov. Cond. lever latency	0.7	0.9	3.3	-1.8	0.7	0.1	0.1
Pavlov. Cond. magazine entry latency	0.2	0.3	0.8	0.9	-0.7	0.2	0.2
Pavlov. Cond. change in total contacts	0.9	0.9	1.6	1.1	-1.3	0.7	0.7
Pavlov. Cond. index score	0.4	0.6	1.0	0.8	-1.0	0.5	0.6
Pavlov. Cond. latency score	0.4	0.5	1.0	0.8	-1.0	0.4	0.5
Pavlov. Cond. lever contacts	0.6	0.7	2.5	1.6	-0.7	-0.1	-0.1
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	-0.5	0.5	-0.1	-0.2
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.1	0.9	-1.0	0.5	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.0	1.0	-0.8	0.3	0.3
Pavlov. Cond. response bias	0.4	0.5	1.5	1.2	-0.7	0.2	0.2
Pavlov. Cond. lever latency	2.0	2.7	3.8	-1.8	1.9	-1.4	-1.3
Pavlov. Cond. magazine entry latency	5.0	5.7	8.9	2.7	-3.0	1.8	1.8
Pavlov. Cond. change in total contacts	6.4	8.9	13.3	2.0	-3.7	3.1	3.0
Pavlov. Cond. index score	4.3	5.5	8.3	2.5	-2.9	2.0	1.9
Pavlov. Cond. latency score	4.9	6.1	9.3	2.6	-3.0	2.1	2.1
Pavlov. Cond. lever contacts	2.8	3.8	5.3	2.1	-2.3	1.7	1.6
Pavlov. Cond. magazine entry number	4.5	5.5	8.3	-2.4	2.9	-1.9	-2.0
Pavlov. Cond. intertrial magazine entries	2.0	2.6	8.8	-3.0	0.4	0.8	0.8
Pavlov. Cond. lever-magazine prob. diff.	4.2	5.3	7.6	2.7	-2.8	1.8	1.8
Pavlov. Cond. response bias	3.6	4.9	7.3	2.2	-2.7	1.9	1.9
Time in closed arm before self-admin	1.4	1.6	5.2	2.3	-0.8	-0.5	-0.5
Time in closed arm after self-admin	0.2	0.2	0.4	-0.6	0.5	-0.2	-0.2
Time in open arm before self-admin	0.7	0.7	1.4	-0.0	1.2	-0.8	-0.8
Time in open arm after self-admin	1.1	1.2	1.6	0.5	1.2	-1.3	-1.3
Bone: periosteal estimation	0.2	0.4	1.1	-1.0	0.7	0.1	0.1
Bone: periosteal perimeter	0.8	1.3	3.0	-1.7	1.4	-0.3	-0.3
Bone: post-yield work	0.7	0.9	1.3	-0.7	-0.8	1.1	1.1
Progressive ratio test 1 active lever presses	0.8	0.8	1.3	-0.5	-0.8	1.1	1.0
Progressive ratio test 1 breakpoint	0.2	0.3	0.4	-0.3	-0.4	0.7	0.6
Progressive ratio test 1 inactive lever presses	2.1	2.3	3.2	-0.6	-1.7	1.8	1.7
Progressive ratio test 2 active lever presses	0.9	1.0	1.4	0.1	-1.2	1.2	1.0
Progressive ratio test 2 breakpoint	1.3	1.5	2.1	-0.1	-1.4	1.5	1.3
Progressive ratio test 2 inactive lever presses	2.1	2.4	4.0	0.2	-2.0	1.7	1.6
Incentive Sensitization - Responses	1.0	1.0	1.8	0.3	-1.3	1.0	1.0
Incentive Sensitization - Breakpoint	1.2	1.2	2.1	0.1	-1.4	1.2	1.1
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.1	0.4	-0.3	-0.0	-0.0
Progressive ratio	0.5	0.6	0.9	0.3	-1.0	0.7	0.8
Food seeking constrained by brief footshock	0.3	0.4	1.0	-1.0	0.0	0.5	0.6
Seeking ratio, punishment vs. effort	0.1	0.2	0.5	-0.7	0.4	0.0	-0.2
Retroperitoneal fat weight	0.6	2.0	6.7	-2.6	1.0	0.5	0.5
Reaction time number correct	1.6	2.3	2.8	1.5	1.2	-1.7	-1.6
Reaction time mean minus median	0.8	1.0	2.5	-1.6	1.1	-0.5	-0.5
Reaction time mean minus median AUC	1.1	1.5	4.1	-2.0	1.2	-0.4	-0.4
Reaction time num false alarms	1.0	1.4	2.1	0.0	1.3	-1.5	-1.3
Reaction time num false alarms AUC	0.9	1.3	2.0	0.1	1.2	-1.4	-1.3
Reaction time trials correct on left	1.6	2.3	2.8	1.5	1.2	-1.7	-1.6
Reaction time trials on left	1.7	2.4	3.0	1.5	1.2	-1.7	-1.7
Reaction time mean	0.0	0.0	0.0	-0.2	-0.0	-0.0	0.1
Reaction time mean AUC	0.0	0.0	0.0	-0.1	0.0	-0.1	0.0
Median of all reaction times	0.1	0.1	0.2	0.4	-0.4	0.1	0.3
Reaction time omissions	0.4	0.5	0.7	-0.3	0.8	-0.8	-0.8
Reaction time false alarm rate	0.2	0.3	0.7	-0.9	0.5	-0.4	-0.3
Reaction time premature initiation rate	2.5	3.4	4.5	1.5	-2.1	1.9	1.9
Reaction time premature initiations	1.3	1.8	3.2	1.8	-1.4	1.0	1.0
Std. dev. reaction times	0.5	0.6	2.1	-1.4	0.7	-0.1	-0.0
Reaction time trials completed	1.7	2.4	3.0	1.5	1.2	-1.7	-1.7
Reaction time trials AUC	1.4	2.0	2.3	1.5	1.0	-1.5	-1.5
Run reversals in cocaine runway, females	2.3	2.2	2.9	1.4	1.4	-1.7	-1.5
Run reversals in cocaine runway, males	0.3	0.3	0.7	-0.8	0.7	-0.2	-0.2
Latency to leave start box in cocaine runway	0.0	0.0	0.1	-0.4	0.1	0.1	-0.0
Latency to leave start box in cocaine runway, F	0.2	0.2	0.4	0.7	0.2	-0.4	-0.5
Latency to leave start box in cocaine runway, M	1.2	1.2	2.4	-1.5	-0.3	1.1	1.0
Std. dev. time between licks in bursts	1.3	1.6	2.3	1.5	-1.5	0.7	1.0
Total sessions with >9 infusions	1.2	1.3	1.8	-1.2	-0.7	1.3	1.3
Short access day 1 total inactive lever presses	1.9	2.2	3.1	-1.2	-1.1	1.7	1.8
Short access day 10 total inactive lever presses	0.4	0.4	0.7	-0.8	-0.2	0.4	0.8
Short access day 1 total infusions	1.6	1.7	2.1	-1.4	-0.9	1.4	1.4
Short access day 10 total infusions	0.4	0.4	0.7	-0.6	-0.4	0.8	0.7
Short access total infusions	2.0	2.3	3.1	-1.4	-1.1	1.8	1.6
Short access day 1 locomotion	0.3	0.3	0.6	-0.2	-0.5	0.7	0.8
Short access day 10 total locomotion	0.0	0.0	0.0	0.2	0.1	-0.1	-0.0
Short access total locomotion	0.5	0.5	0.7	-0.8	-0.4	0.8	0.8
One hour access (0.3 mA shock)	0.0	0.1	0.1	0.3	0.1	-0.2	-0.3
Compulsive drug intake	0.4	0.4	1.0	1.0	-0.5	-0.4	-0.4
One hour access (shock baseline)	0.1	0.1	0.4	-0.0	0.6	-0.2	-0.2
Social response proportion	1.0	1.0	1.7	-0.6	-1.0	1.1	1.3
Social responses	0.0	0.1	0.1	0.3	0.1	-0.3	0.0
Social time	0.5	0.7	2.2	1.5	-0.4	-0.6	-0.1
Soleus weight	0.1	0.4	0.8	0.2	-0.9	0.5	0.6
Bone: stiffness	1.0	1.6	2.2	-1.3	-0.7	1.5	1.4
Tibialis anterior weight	0.1	0.2	0.6	0.2	-0.8	0.2	0.2
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.1	-0.3	0.2	-0.1	-0.1
Time to tail flick, vehicle, after self-admin	2.4	2.5	3.6	0.7	1.6	-1.9	-1.9
Time to tail flick, test, before self-admin	1.2	1.2	2.1	-0.2	1.4	-1.2	-1.2
Time to tail flick, test, after self-admin	0.8	0.8	1.0	0.8	0.8	-1.0	-1.0
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.1	0.3	-0.2	0.0	0.0
Delta time to tail flick, test, before/after SA	0.5	0.4	1.5	1.2	-0.3	-0.2	-0.2
Tibia length	0.3	0.9	1.4	-0.9	-0.6	1.2	1.1
Ambulatory time before self-admin	0.4	0.4	0.8	0.2	-0.9	0.6	0.6
Ambulatory time after self-admin	0.6	0.7	0.9	0.4	-1.0	0.9	0.9
Bone: tissue strength	0.5	0.5	0.9	0.2	-0.7	0.7	0.9
Total heroin consumption	0.3	0.4	0.7	-0.2	-0.9	0.6	0.6
Bone: trabecular number	0.3	0.5	0.7	0.4	0.8	-0.8	-0.6
Bone: trabecular spacing	0.6	0.7	1.2	-1.1	-0.5	0.9	0.9
Bone: trabecular thickness	0.1	0.2	0.6	0.8	-0.1	-0.1	-0.2
Bone: trabecular tissue density	0.7	0.9	2.0	0.9	-1.4	0.8	0.7
Water consumed over 24 hours	0.8	1.0	2.1	-1.4	-0.4	0.9	1.0
Number of responses in last shaping day	1.1	1.2	2.4	0.9	-1.5	0.9	0.8