Ndufa12

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Ndufa12	0.42	0.1	0.0e+00	0.32	0.33	0.32	0.33	1.1e-30	3.8e-31	2.0e-30	5.6e-31
2	PL	gene expression	Ndufa12	0.07	0.03	3.5e-12	0.13	0.11	0.11	0.12	1.5e-14	3.0e-12	4.8e-12	2.9e-13
3	Adipose	gene expression	Ndufa12	0.31	0.12	0.0e+00	0.19	0.18	0.21	0.2	4.3e-21	5.1e-20	1.5e-22	5.5e-22
4	Liver	gene expression	Ndufa12	0.41	0.09	0.0e+00	0.44	0.47	0.47	0.45	6.0e-53	9.6e-58	1.6e-57	8.0e-56
5	OFC	gene expression	Ndufa12	0.22	0.12	1.5e-03	0.13	0.11	0.1	0.09	4.7e-04	1.7e-03	1.9e-03	4.3e-03
6	BLA	gene expression	Ndufa12	0.11	0.06	1.3e-03	-0	0.01	0.01	0	3.8e-01	6.0e-02	1.3e-01	2.9e-01
7	Brain	mRNA stability	Ndufa12	0.04	0.02	1.4e-03	0.03	0.02	0.02	0.03	3.8e-04	2.5e-03	4.0e-03	1.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7
Bone: apparent density	0.2	0.3	1.0	-0.4	-0.2	0.3	0.0	-0.7	-1.0	0.2
Area under the delay curve	0.5	0.5	2.2	-0.9	0.4	0.4	0.1	-0.2	-0.0	1.5
BMI with tail	1.7	5.6	15.5	-2.2	2.4	2.2	-1.9	2.2	-3.9	-0.1
BMI without tail	3.9	8.1	12.6	-3.0	3.2	3.0	-2.7	2.6	-3.6	-1.3
Body weight	11.8	49.3	63.8	-7.8	8.0	7.3	-7.0	6.8	-7.6	-3.7
Weight adjusted by age	0.2	0.3	1.0	-0.5	0.7	0.2	-0.1	1.0	0.0	-0.1
Bone surface	0.2	0.3	0.6	-0.8	0.3	0.6	-0.6	-0.1	-0.8	0.6
Bone volume	0.4	0.6	2.0	-0.9	0.5	0.8	-0.5	0.1	-1.4	0.5
Breakpoint value in progressive ratio session	1.4	1.6	3.1	1.4	-1.2	-1.5	1.8	-0.9	-0.1	1.2
Number of licking bursts	0.2	0.3	0.9	-0.1	0.1	0.4	-0.3	-0.8	-0.9	-0.2
Context. condit. distance diff. score	0.8	0.9	2.7	-1.0	1.0	1.0	-0.8	1.6	0.2	0.2
Locomotion velocity, session 1	0.4	0.5	1.0	0.7	-0.7	-1.0	0.8	0.1	0.7	0.4
Locomotion distance, session 1	0.1	0.1	0.6	-0.3	0.2	-0.2	-0.0	0.7	0.1	0.3
Locomotion velocity, session 2	0.2	0.2	0.5	0.7	0.1	-0.6	0.6	-0.2	-0.2	-0.4
Locomotion distance, session 2	0.5	0.6	1.1	-0.9	1.0	0.5	-0.6	0.9	-1.0	-0.2
Locomotion velocity, session 3	0.3	0.4	2.0	0.2	0.4	-0.4	0.0	1.4	0.4	0.4
Locomotion distance, session 3	0.6	0.7	2.4	-0.7	1.1	0.5	-0.6	1.6	-0.4	0.1
Stereotopy head waving bouts, day 3	0.7	0.9	2.2	0.9	-1.5	-0.9	0.9	-1.2	0.5	-0.2
Stereotopy head waving duration, day 3	0.2	0.2	0.5	0.5	-0.7	-0.5	0.5	-0.6	0.2	0.0
Locomotion velocity, session 7	0.4	0.4	1.2	-0.4	1.1	0.3	-0.2	1.0	-0.4	-0.2
Locomotion distance, session 7	0.2	0.2	0.6	-0.4	0.8	0.1	-0.2	0.8	-0.1	0.3
Stereotopy head waving bouts, day 7	0.2	0.2	0.9	0.4	0.2	-0.1	0.1	-0.2	-0.9	-0.4
Stereotopy head waving duration, day 7	0.2	0.2	0.7	0.6	-0.1	-0.3	0.3	-0.6	-0.8	0.0
Locomotion velocity, session 8	0.5	0.6	2.0	-0.5	1.0	0.4	-0.1	1.4	-0.2	-0.6
Locomotion distance, session 8	2.9	4.3	9.9	-2.4	2.5	2.0	-1.8	3.1	-0.9	-0.4
Degree of sensitization distance	0.2	0.2	0.6	0.4	-0.2	-0.4	0.4	-0.8	0.1	0.4
Degree of sensitization stereotypy	0.3	0.4	1.0	1.0	-0.2	-0.5	0.5	-0.6	-0.8	0.2
Conditioned locomotion	0.1	0.1	0.4	-0.7	-0.1	0.3	-0.4	0.2	-0.3	0.3
Cocaine response after cond. corrected	0.3	0.3	0.8	-0.9	0.4	0.8	-0.5	-0.3	-0.6	0.1
Cocaine response after cond. not corrected	0.3	0.3	1.0	-1.0	0.4	0.8	-0.6	-0.0	-0.2	0.1
Cocaine response before conditioning	0.2	0.3	1.5	0.3	-0.3	-0.3	0.3	0.3	1.2	-0.2
Saline control response	0.4	0.6	1.5	-0.3	0.9	0.7	-1.2	-0.1	-0.8	-0.7
Bone: connectivity density	0.4	0.6	2.1	0.6	-1.1	-0.6	0.6	-1.5	0.1	0.1
Bone: cortical apparent density	0.4	0.5	1.9	-0.6	1.0	0.5	-0.4	1.4	-0.0	-0.3
Bone: cortical area	1.8	2.7	6.2	-2.5	1.3	1.9	-1.7	1.4	-1.5	-0.5
Bone: cortical porosity	0.1	0.1	0.8	-0.2	0.4	0.1	-0.1	0.0	-0.9	-0.2
Bone: cortical porosity	0.3	0.4	1.1	-0.7	0.8	0.4	-0.3	0.3	-1.1	0.1
Bone: cortical thickness	1.1	1.8	3.7	-1.9	1.0	1.4	-1.5	1.3	-0.9	-1.1
Bone: cortical thickness	0.3	0.3	0.8	0.4	-0.9	-0.7	0.5	-0.5	-0.2	0.2
Bone: cortical tissue density	0.4	0.5	2.0	-0.5	1.0	0.4	-0.4	1.4	0.1	-0.3
Condit. Reinf. active minus inactive responses	2.0	2.2	3.2	1.8	-1.8	-1.6	1.8	-0.7	1.6	0.8
Condit. Reinf. active-inactive response ratio	1.2	1.3	2.2	1.2	-1.3	-1.1	1.5	-0.9	0.8	0.9
Condit. Reinf. active responses	3.3	4.0	6.2	2.4	-2.5	-2.2	2.2	-1.6	1.8	0.7
Condit. Reinf. inactive responses	2.1	2.4	4.2	2.0	-1.8	-1.9	1.6	-1.6	1.0	0.5
Incentive salience index mean	0.5	0.7	1.1	0.9	-1.0	-0.8	1.1	-0.1	1.1	0.1
Condit. Reinf. lever presses	0.1	0.1	0.3	-0.2	0.3	0.1	0.3	0.5	-0.0	-0.4
Condit. Reinf. active minus inactive responses	0.4	0.5	1.5	1.2	-0.0	-0.8	1.2	0.1	-0.5	-0.1
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.5	0.5	0.2	-0.1	0.4	0.2	-0.7	-0.4
Condit. Reinf. active responses	0.4	0.5	1.3	1.1	-0.1	-0.9	1.1	0.2	-0.2	0.3
Condit. Reinf. inactive responses	1.0	1.3	2.2	1.2	-0.8	-1.4	1.5	0.0	1.1	1.1
Condit. Reinf. lever presses	0.5	0.6	2.6	0.6	0.7	-0.5	0.8	0.1	-1.6	-0.0
Condit. Reinf. lever reinforcers received	0.3	0.4	1.1	1.0	0.0	-0.8	1.1	0.4	-0.2	0.3
Conditioned reinforcement - actives	1.1	1.1	2.2	-1.1	1.2	1.5	-1.2	-0.3	-0.3	-1.1
Conditioned reinforcement - inactives	0.2	0.3	0.6	-0.5	0.3	0.7	-0.5	-0.4	-0.4	-0.8
Conditioned locomotion	1.2	1.5	2.4	-1.1	1.5	1.5	-1.4	0.8	-0.4	-1.4
Patch foraging indifference point 0 sec	0.2	0.3	1.8	-0.0	-0.1	0.0	-0.1	-1.3	0.1	-0.1
Patch foraging indifference point AUC	0.3	0.4	0.8	-0.2	0.0	0.4	-0.6	-0.8	-0.8	-0.9
Delay disc. indifference point, 0s delay	0.4	0.4	1.1	0.2	-0.4	-0.3	1.0	-0.4	-1.0	0.6
Delay disc. indifference point, 16s delay	1.0	1.0	3.1	-1.5	0.9	0.7	-0.4	0.0	-0.7	1.8
Delay disc. indifference point, 2s delay	0.5	0.6	1.4	-1.2	0.8	0.9	-0.6	0.9	0.2	-0.0
Delay disc. indifference point, 24s delay	1.1	1.0	3.1	-1.7	1.0	0.9	-0.7	0.9	0.3	1.0
Delay disc. indifference point, 4s delay	0.2	0.2	0.5	-0.7	0.3	0.3	-0.1	-0.7	0.2	0.6
Delay disc. indifference point, 8s delay	0.7	0.8	4.1	-0.4	-0.1	-0.0	0.6	-0.8	-0.3	2.0
Indifference point function ln k	0.1	0.1	0.4	-0.2	-0.1	-0.1	0.3	0.6	0.3	0.6
Indifference point function log k	0.1	0.1	0.4	-0.2	-0.1	-0.1	0.3	0.6	0.3	0.6
Patch foraging total patch changes 0 sec	0.1	0.2	1.7	0.0	-0.1	-0.1	-0.0	-1.3	0.0	0.0
Patch foraging total patch changes 12 sec	1.1	1.4	3.2	-1.1	0.9	1.1	-1.2	-0.5	-1.2	-1.8
Patch foraging total patch changes 18 sec	0.7	0.9	3.7	-0.0	0.3	0.7	-0.6	-1.3	-0.2	-1.9
Patch foraging total patch changes 24 sec	1.3	1.6	4.3	-1.0	1.2	1.3	-1.4	-0.2	-0.9	-2.1
Patch foraging total patch changes 6 sec	0.3	0.5	2.8	0.3	-0.4	-0.1	-0.1	-1.7	-0.2	-0.3
Patch foraging time to switch 0 sec	0.1	0.1	0.5	-0.0	0.7	0.2	-0.1	0.1	-0.2	-0.4
Patch foraging water rate 0 sec	1.1	1.7	4.0	-2.0	0.9	1.6	-1.6	1.3	-0.6	-0.3
Patch foraging water rate 12 sec	2.8	4.3	6.3	-2.3	1.8	2.5	-2.4	1.1	-2.5	-1.6
Patch foraging water rate 18 sec	0.1	0.1	0.5	0.0	-0.1	0.2	-0.4	-0.2	-0.7	0.5
Patch foraging water rate 24 sec	4.6	6.4	11.5	-3.4	2.9	3.0	-2.4	2.7	-1.4	-0.7
Patch foraging water rate 6 sec	5.8	8.5	12.2	-3.5	3.3	3.3	-2.9	2.6	-2.7	-1.5
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.6	-0.2	-0.2	-0.3	0.4	-0.1	-0.8	0.0
Distance traveled before self-admin	0.4	0.4	1.2	-0.8	0.5	0.6	-0.7	1.1	0.1	0.0
Distance traveled after self-admin	0.6	0.7	1.6	-1.0	1.0	0.6	-0.6	1.3	-0.7	0.2
Extensor digitorum longus weight	0.2	0.8	2.7	-0.8	0.3	0.6	-0.6	0.2	-1.6	1.1
Bone: elastic displacement	2.7	3.1	4.5	1.7	-1.8	-2.1	2.1	-1.4	1.7	1.3
Bone: elastic work	1.5	2.0	2.8	1.1	-1.6	-1.7	1.4	-1.1	1.5	1.3
Bone: endosteal estimation	0.6	1.3	5.9	-0.2	-0.1	0.2	0.1	-1.3	-1.0	2.4
Bone: endosteal perimeter	1.4	2.9	7.5	-2.7	1.5	2.2	-1.7	1.1	-1.2	0.4
Epididymis fat weight	2.6	6.2	8.1	-2.7	2.9	2.6	-2.6	2.6	-2.5	-1.1
Delta time in closed arm before/after self-admin	0.2	0.2	0.6	-0.4	0.1	0.5	-0.6	0.4	-0.7	0.0
Delta time in open arm before/after self-admin	1.6	1.5	3.7	1.5	-1.1	-1.5	1.9	-0.7	-0.6	0.7
Diff in mean of infusions in LGA sessions	1.0	1.1	1.9	1.2	-1.2	-1.4	0.9	-0.7	0.9	0.8
Delay discount exponential model param	0.5	0.5	1.6	1.1	-0.6	-0.5	0.1	0.1	-0.0	-1.3
Extinction: sum of active levers before priming	0.3	0.3	0.9	0.5	-0.4	-0.5	0.5	-0.4	0.3	1.0
Active lever presses in extinction session 6	0.4	0.4	1.3	-0.5	0.5	0.3	-0.1	0.1	-1.1	0.8
Bone: final force	0.8	1.3	3.4	-1.6	0.6	1.3	-0.9	0.2	-1.8	0.4
Bone: final moment	0.8	1.3	3.1	-1.7	0.7	1.3	-1.0	0.2	-1.8	0.3
Food consumed during 24 hour testing period	0.3	0.4	1.5	-0.1	0.5	0.4	-0.6	0.5	-0.2	-1.2
Glucose	0.1	0.2	0.5	-0.3	-0.7	0.3	-0.4	-0.2	-0.5	-0.3
Heart weight	0.6	0.9	3.1	0.1	0.8	-0.4	0.8	0.1	-1.2	1.8
Delay discount hyperbolic model param	0.5	0.5	1.4	1.2	-0.6	-0.6	0.2	0.0	0.0	-1.1
Intermittent access intake day 1-15 change	0.7	0.7	2.0	-0.7	0.3	0.9	-1.2	-0.4	0.1	-1.4
Intermittent access intake escalation	0.8	0.8	2.3	-0.6	0.4	0.9	-1.1	-0.6	0.0	-1.5
Intermittent access intake escalation 2	0.2	0.2	0.7	-0.1	-0.4	0.2	-0.5	-0.3	0.8	-0.6
Intermitt. access day 1 inactive lever presses	2.6	2.7	5.6	2.1	-1.6	-1.7	1.8	-2.4	0.5	0.6
Intermitt. access day 15 inactive lever presses	1.6	1.7	3.0	1.7	-1.5	-1.7	1.6	0.4	0.7	0.9
Intermitt. access escalation Index	1.4	1.2	2.2	1.4	-1.5	-1.1	0.9	-0.6	1.4	0.5
Intermittent access day 1 total infusions	3.0	3.4	5.5	-2.0	2.3	2.2	-2.0	1.9	-0.8	-1.2
Intermittent access day 15 total infusions	3.8	4.3	7.0	-2.3	2.2	2.6	-2.7	1.4	-0.7	-1.9
Intermittent access terminal intake (last 3 days)	3.8	4.1	6.2	-2.4	2.1	2.5	-2.5	1.9	-0.6	-1.5
Intermittent access total infusions	3.9	4.3	7.1	-2.4	2.4	2.7	-2.4	1.8	-0.8	-1.5
Intermittent access day 1 locomotion	1.8	1.9	3.1	-1.5	1.8	1.7	-1.6	1.0	-0.8	-0.8
Intermittent access day 15 total locomotion	2.4	2.6	6.0	-1.3	1.7	1.8	-1.8	1.0	-0.0	-2.5
Intermittent access total locomotion	2.3	2.6	3.8	-1.6	1.9	2.0	-2.0	1.1	-0.5	-1.7
Intermittent access standard deviation	2.6	2.7	5.6	-1.7	1.5	2.0	-2.4	0.4	0.0	-2.1
Left kidney weight	3.0	8.4	15.0	-3.1	3.9	2.8	-2.6	3.0	-2.9	-1.6
Right kidney weight	1.9	5.3	9.5	-2.4	3.1	2.2	-2.3	2.0	-2.6	-0.8
Cocaine induced anxiety	1.8	2.0	3.1	1.7	-1.5	-1.6	1.8	-0.7	0.6	1.6
Post-drug Anxiety	1.2	1.3	2.2	1.5	-1.1	-1.4	1.2	-0.3	1.0	1.2
Baseline Anxiety	0.5	0.5	1.2	-0.5	0.4	0.6	-1.0	0.4	0.6	-1.1
Tail length	8.5	25.7	34.6	-5.8	5.9	5.4	-5.2	4.8	-3.8	-4.1
Length with tail	12.2	44.8	62.2	-7.5	7.9	7.0	-6.9	6.9	-5.1	-5.1
Length without tail	6.0	13.1	19.2	-4.0	4.4	3.7	-3.6	4.0	-2.9	-2.5
Times rat made contact with spout	2.6	3.0	7.1	-1.5	0.7	2.2	-2.1	0.6	-1.2	-2.7
Lifetime Intake	3.2	3.7	5.7	-2.2	2.3	2.4	-2.1	1.9	-0.5	-1.1
Liver weight, left	0.8	1.2	2.4	-1.6	1.3	1.1	-1.0	1.4	-0.6	-0.1
Liver weight, right	1.0	1.7	3.3	-1.2	1.8	0.8	-0.5	1.7	-1.7	-0.9
Locomotor activity	4.4	7.0	10.3	-3.0	3.2	2.6	-2.6	3.0	-2.6	-0.9
Locomotor testing distance	2.0	3.3	6.0	-2.1	2.5	1.8	-1.7	2.0	-1.5	-0.1
Locomotor testing rearing	0.5	0.8	1.6	-1.3	1.3	0.8	-0.9	0.7	0.1	-0.0
Locomotion in novel chamber	0.3	0.4	1.2	-0.5	0.5	0.3	-0.4	1.1	0.6	0.4
Locomotion in novel chamber post-restriction	0.1	0.2	0.4	-0.5	0.6	0.5	-0.6	-0.0	0.1	-0.3
Fecal boli incidents, locomotor time 1	0.4	0.4	1.4	-0.8	0.7	0.6	-0.1	0.3	-1.2	0.0
Change in fecal boli incidents, locomotor task	1.4	1.3	3.2	1.4	-1.2	-1.0	0.6	-0.3	1.8	1.0
Time >=10cm from walls, locomotor time 1	1.1	1.1	2.7	1.2	-0.8	-1.1	1.1	-0.5	0.3	1.6
Bouts of movement, locomotor time 1	0.7	0.8	1.4	0.7	-0.8	-0.9	1.1	-0.7	-0.9	1.2
Total resting periods, locomotor time 1	1.0	1.0	1.8	1.0	-1.1	-1.2	1.3	-0.5	-0.3	1.3
Rest time, locomotor task time 1	1.8	2.0	3.1	1.4	-1.7	-1.6	1.6	-1.2	0.4	1.5
Distance moved, locomotor task time 1	1.0	1.1	3.4	-0.7	1.2	0.9	-0.9	0.8	-0.1	-1.8
Vertical activity count, locomotor time 1	3.3	3.5	4.7	-2.1	2.2	1.9	-1.9	2.0	-0.9	-1.8
Time >=10cm from walls, locomotor time 2	0.4	0.4	1.1	0.7	-0.4	-0.4	1.0	-0.9	0.3	0.1
Bouts of movement, locomotor time 2	0.2	0.2	0.6	-0.5	0.1	0.0	0.2	0.8	-0.1	0.6
Total resting periods, locomotor time 2	0.2	0.3	1.0	-0.2	-0.2	-0.3	0.6	0.6	-0.0	1.0
Rest time, locomotor task time 2	2.1	2.4	4.3	1.6	-1.7	-1.6	1.7	-1.0	0.6	2.1
Distance moved, locomotor task time 2	1.1	1.2	3.9	-0.8	1.2	0.9	-1.0	0.5	-0.8	-2.0
Vertical activity count, locomotor time 2	6.8	7.4	10.4	-2.9	3.0	2.9	-2.5	1.6	-3.2	-2.6
Light reinforcement 1	0.1	0.2	0.4	-0.2	0.1	0.5	-0.6	0.6	-0.5	-0.3
Light reinforcement 2	0.6	0.8	2.1	1.1	-1.0	-0.6	0.5	-1.4	-0.3	0.6
Bone: marrow area	0.6	1.2	5.6	-0.2	-0.1	0.2	0.1	-1.3	-1.1	2.4
Bone: maximum diameter	1.8	3.3	7.2	-2.7	1.5	2.3	-1.9	1.4	-1.7	-0.1
Bone: maximum force	0.3	0.5	1.7	-0.8	0.1	0.6	-0.2	0.2	-1.3	0.8
Bone: maximum moment	0.3	0.5	1.4	-0.9	0.2	0.5	-0.2	0.1	-1.2	0.8
Mean time between licks in bursts	0.3	0.4	1.2	-0.5	0.9	0.3	0.3	1.1	-0.6	0.5
Mean num. licks in bursts	0.2	0.3	0.8	-0.2	-0.3	0.5	-0.5	0.5	0.5	-0.9
Cd content in liver	1.2	1.3	5.0	-0.6	1.7	0.8	-0.0	0.2	-2.2	0.3
Co content in liver	3.4	4.0	5.3	-2.3	2.0	2.1	-1.9	2.2	-0.7	-2.3
Cu content in liver	1.5	1.8	3.6	-1.3	1.4	1.2	-1.6	0.3	-1.9	-1.1
Fe content in liver	0.6	0.7	1.3	-1.1	1.0	1.0	-0.8	0.4	-0.8	0.4
K content in liver	0.7	0.7	2.8	0.2	-0.0	-0.2	-0.6	-1.3	0.2	-1.7
Mg content in liver	0.5	0.5	1.5	1.0	-0.4	-0.8	0.1	-1.2	0.5	-0.3
Mn content in liver	0.1	0.2	0.6	-0.1	0.2	0.1	-0.7	-0.2	-0.0	-0.8
Na content in liver	0.3	0.4	1.8	-0.4	-0.1	0.4	-0.3	-0.3	-0.4	-1.3
Rb content in liver	0.4	0.5	2.1	0.4	-0.6	-0.5	0.4	-1.5	0.2	-0.5
Se content in liver	0.3	0.3	1.1	0.2	0.9	-0.1	-0.3	1.1	-0.2	0.4
Sr content in liver	0.2	0.2	0.3	-0.6	0.6	0.3	-0.1	0.1	-0.6	-0.3
Zn content in liver	0.2	0.2	0.8	0.1	0.7	-0.2	-0.3	0.9	-0.1	-0.0
Bone: minimum diameter	3.2	6.0	10.8	-3.3	2.3	3.0	-2.5	2.3	-2.2	-0.4
Time in familiar zone, hab. session 1	0.2	0.2	0.3	0.4	0.4	-0.5	0.6	0.3	-0.3	0.3
Time in novel zone, hab. session 1	0.7	0.7	1.5	0.8	-1.1	-0.4	0.4	-1.2	0.5	0.8
Total zone transitions, hab. session 1	2.3	3.2	5.6	-2.2	2.1	1.8	-1.1	2.4	-1.5	-0.9
Total locomotion distance, hab. session 1	2.1	2.9	6.4	-1.7	2.4	1.5	-1.0	2.5	-1.2	-0.7
Locomotion velocity, hab. session 1	2.6	3.7	8.1	-2.1	2.5	1.8	-1.3	2.8	-1.1	-1.1
Time in familiar zone, hab. session 2	0.1	0.1	0.1	0.4	-0.1	-0.3	0.3	0.0	-0.3	-0.1
Time in novel zone, hab. session 2	0.4	0.4	1.5	0.6	-0.3	-0.5	0.8	-0.4	0.3	1.2
Total zone transitions, hab. session 2	0.5	0.7	2.6	-0.6	1.2	0.2	0.1	1.6	-0.2	0.6
Total locomotion distance, hab. session 2	0.4	0.5	1.8	-0.4	0.9	0.2	0.1	1.3	-0.2	0.8
Locomotion velocity, hab. session 2	0.5	0.6	2.3	-0.6	1.0	0.3	0.0	1.5	0.1	0.7
Novel to familiar place preference ratio	0.6	0.6	2.0	0.4	0.9	-0.1	0.5	0.8	0.3	-1.4
Novelty place preference	0.6	0.6	1.7	0.8	0.8	-0.4	0.9	0.6	0.4	-1.3
Time in novel zone, NPP test	0.5	0.5	1.4	0.7	0.9	-0.3	0.7	0.7	0.2	-1.2
Total zone transitions, NPP test	0.9	1.2	3.6	-1.3	1.4	0.7	-0.5	1.9	-0.7	0.3
Total locomotion distance, NPP test	0.5	0.7	2.5	-0.9	1.0	0.6	-0.7	1.6	-0.2	-0.0
Locomotion velocity, NPP test	0.3	0.5	1.8	-0.7	0.7	0.4	-0.5	1.3	0.2	-0.0
Intraocular pressure	0.9	1.3	3.1	1.4	-1.8	-0.9	0.9	-1.0	1.2	-0.3
Delta distance traveled before/after self-admin	0.1	0.2	0.7	-0.4	0.4	0.2	-0.3	-0.2	-0.8	-0.2
Delta ambulatory time before/after self-admin	0.2	0.3	0.7	0.2	-0.3	-0.4	0.5	-0.8	-0.5	0.5
Parametrial fat weight	0.4	0.8	3.0	0.0	-0.7	-0.8	0.9	0.2	-0.6	1.7
Pavlov. Cond. lever latency	0.5	0.6	1.1	-0.8	1.0	0.7	-0.4	0.9	-0.8	0.7
Pavlov. Cond. magazine entry latency	0.4	0.5	1.8	0.9	-0.8	-0.7	1.3	0.1	0.2	0.1
Pavlov. Cond. change in total contacts	0.3	0.3	0.9	0.6	-0.9	-0.2	0.2	-0.9	0.3	-0.5
Pavlov. Cond. index score	0.4	0.5	0.9	0.9	-1.0	-0.8	1.0	-0.3	0.3	-0.2
Pavlov. Cond. latency score	0.4	0.5	1.0	0.9	-1.0	-0.8	0.9	-0.4	0.4	-0.4
Pavlov. Cond. lever contacts	0.2	0.2	1.1	0.2	-0.3	-0.1	-0.1	-0.2	0.2	-1.0
Pavlov. Cond. magazine entry number	0.3	0.3	0.8	-0.6	0.7	0.5	-0.9	-0.3	-0.3	-0.4
Pavlov. Cond. intertrial magazine entries	0.3	0.4	2.4	-0.3	-0.5	0.2	-0.4	0.2	0.1	1.5
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	0.9	0.7	-0.7	-0.6	0.9	-0.2	0.1	-0.1
Pavlov. Cond. response bias	0.1	0.2	0.4	0.5	-0.6	-0.3	0.4	-0.1	0.4	-0.5
Pavlov. Cond. lever latency	0.2	0.3	0.6	-0.4	-0.4	0.3	-0.7	-0.3	0.8	-0.4
Pavlov. Cond. magazine entry latency	0.3	0.4	0.8	-0.5	-0.0	0.7	-0.6	0.8	0.5	-0.9
Pavlov. Cond. change in total contacts	1.5	2.0	4.3	-1.5	2.1	1.4	-0.8	2.0	-1.0	-0.3
Pavlov. Cond. index score	0.4	0.6	1.3	-0.8	0.8	0.9	-0.5	1.1	-0.4	-0.4
Pavlov. Cond. latency score	0.3	0.3	0.9	-0.5	0.6	0.7	-0.3	0.9	-0.2	-0.4
Pavlov. Cond. lever contacts	0.5	0.7	3.3	-0.1	0.8	0.3	0.3	0.4	-1.8	0.6
Pavlov. Cond. magazine entry number	0.4	0.5	1.1	0.8	-0.4	-1.0	0.8	-0.9	0.1	0.6
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.3	0.3	0.1	-0.5	0.5	0.5	-0.2	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	1.4	-1.0	0.9	1.1	-0.8	1.2	-0.4	-0.6
Pavlov. Cond. response bias	0.5	0.7	2.4	-0.5	1.0	0.7	-0.2	0.8	-1.5	0.2
Time in closed arm before self-admin	0.2	0.3	0.6	0.2	0.7	0.1	-0.1	0.8	0.5	-0.6
Time in closed arm after self-admin	0.6	0.6	1.3	-0.7	1.1	0.9	-0.7	0.3	-1.1	0.1
Time in open arm before self-admin	0.1	0.1	0.4	-0.3	-0.4	0.1	-0.2	-0.2	0.6	0.3
Time in open arm after self-admin	1.0	1.1	2.8	1.2	-1.2	-1.3	1.7	-0.2	0.1	0.4
Bone: periosteal estimation	0.7	1.4	2.8	-1.7	0.8	1.3	-1.1	0.4	-1.3	1.3
Bone: periosteal perimeter	1.3	2.1	5.2	-2.3	1.4	1.7	-1.3	1.2	-1.2	0.4
Bone: post-yield work	0.2	0.2	0.9	-0.1	-0.3	0.5	-0.4	-0.1	-1.0	0.2
Progressive ratio test 1 active lever presses	9.3	9.8	15.3	-3.6	3.7	3.8	-3.9	1.8	-1.8	-2.2
Progressive ratio test 1 breakpoint	8.6	8.9	13.9	-3.5	3.5	3.7	-3.7	1.9	-1.7	-2.0
Progressive ratio test 1 inactive lever presses	0.2	0.2	0.4	-0.5	0.5	0.6	-0.5	0.1	-0.5	-0.6
Progressive ratio test 2 active lever presses	3.6	3.8	6.0	-2.0	2.2	2.4	-2.5	1.6	-0.5	-1.8
Progressive ratio test 2 breakpoint	4.1	4.6	7.2	-2.3	2.2	2.6	-2.7	1.7	-0.7	-2.1
Progressive ratio test 2 inactive lever presses	0.4	0.5	1.0	-0.7	0.6	1.0	-1.0	0.6	-0.2	-0.8
Incentive Sensitization - Responses	2.1	2.1	4.0	-1.4	1.3	1.6	-1.7	1.2	-0.2	-2.0
Incentive Sensitization - Breakpoint	1.7	1.8	3.8	-1.2	1.2	1.4	-1.6	1.1	-0.1	-1.9
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.7	-0.2	0.4	0.3	0.2	-0.3	-0.9	-0.5
Progressive ratio	2.4	2.8	9.2	1.5	-1.4	-1.6	1.5	-0.7	3.0	1.2
Food seeking constrained by brief footshock	1.2	1.5	3.3	-1.0	1.2	1.3	-1.8	0.6	-0.3	-1.6
Seeking ratio, punishment vs. effort	2.1	2.5	5.4	-1.4	1.4	1.6	-1.8	0.7	-2.3	-1.5
Retroperitoneal fat weight	2.1	6.9	13.1	-3.0	3.2	2.5	-2.2	3.6	-1.8	-1.3
Reaction time number correct	0.1	0.2	0.5	-0.3	-0.1	0.3	-0.3	0.1	-0.6	0.7
Reaction time mean minus median	1.1	1.5	2.7	1.6	-1.1	-1.6	1.5	-0.5	1.0	0.7
Reaction time mean minus median AUC	1.4	1.9	3.8	1.9	-1.4	-1.7	1.5	-0.6	1.3	0.4
Reaction time num false alarms	0.7	0.9	3.0	0.9	-0.9	-1.0	0.7	-1.7	0.3	0.2
Reaction time num false alarms AUC	1.0	1.3	3.6	1.1	-1.0	-1.3	1.1	-1.9	0.2	0.8
Reaction time trials correct on left	0.1	0.2	0.5	-0.3	-0.1	0.3	-0.3	0.1	-0.6	0.7
Reaction time trials on left	0.1	0.2	0.6	-0.3	-0.2	0.3	-0.2	0.1	-0.5	0.8
Reaction time mean	0.1	0.2	0.6	0.3	-0.2	-0.3	0.2	0.2	0.4	0.8
Reaction time mean AUC	0.0	0.0	0.2	0.1	-0.0	-0.1	0.0	0.3	0.2	0.5
Median of all reaction times	0.1	0.2	0.3	-0.5	0.5	0.4	-0.4	0.5	-0.2	0.5
Reaction time omissions	2.0	2.7	3.6	1.8	-1.2	-1.9	1.9	-1.3	1.2	1.9
Reaction time false alarm rate	0.9	1.3	3.4	1.2	-0.9	-1.2	1.1	-1.8	0.6	0.4
Reaction time premature initiation rate	0.2	0.3	1.4	-0.3	0.5	0.2	0.3	0.2	-1.2	0.6
Reaction time premature initiations	0.3	0.4	1.9	-0.5	0.5	0.5	-0.1	0.4	-1.4	0.5
Std. dev. reaction times	1.2	1.6	2.6	1.5	-1.1	-1.6	1.5	-0.7	1.2	1.1
Reaction time trials completed	0.1	0.2	0.6	-0.3	-0.2	0.3	-0.2	0.1	-0.5	0.8
Reaction time trials AUC	0.1	0.2	0.6	-0.4	-0.1	0.4	-0.3	0.1	-0.7	0.8
Run reversals in cocaine runway, females	1.2	1.1	2.4	-1.6	1.0	1.0	-1.1	1.5	-0.2	0.2
Run reversals in cocaine runway, males	0.1	0.1	0.6	0.8	-0.3	-0.5	0.1	0.1	-0.1	0.0
Latency to leave start box in cocaine runway	0.1	0.2	0.8	-0.1	0.1	0.1	-0.1	0.9	-0.5	0.1
Latency to leave start box in cocaine runway, F	0.4	0.5	1.1	1.0	-0.8	-0.9	0.5	-0.0	0.5	0.5
Latency to leave start box in cocaine runway, M	2.2	2.1	2.6	-1.6	1.3	1.5	-1.4	1.6	-1.4	-1.3
Std. dev. time between licks in bursts	1.2	1.5	3.5	0.9	0.7	-1.3	1.9	0.6	0.5	1.8
Total sessions with >9 infusions	2.7	2.9	4.7	-2.1	2.0	2.1	-2.2	1.5	-0.6	-0.6
Short access day 1 total inactive lever presses	0.0	0.1	0.1	-0.1	-0.2	0.2	-0.2	-0.4	0.2	0.3
Short access day 10 total inactive lever presses	4.0	4.4	7.6	2.5	-2.6	-2.8	2.5	-0.2	1.6	1.2
Short access day 1 total infusions	2.2	2.3	4.5	-2.1	1.4	1.8	-1.7	1.8	-0.2	-0.5
Short access day 10 total infusions	4.8	5.3	8.3	-2.6	2.9	2.7	-2.2	2.2	-1.7	-1.5
Short access total infusions	4.2	4.7	7.2	-2.7	2.5	2.6	-2.2	2.4	-1.1	-0.9
Short access day 1 locomotion	3.2	3.4	5.4	-2.3	1.6	2.1	-2.2	1.8	-1.4	-1.3
Short access day 10 total locomotion	0.2	0.2	0.7	-0.4	0.6	0.3	-0.4	-0.8	0.3	-0.2
Short access total locomotion	2.4	2.5	3.7	-1.8	1.9	1.9	-1.9	0.5	-1.0	-1.5
One hour access (0.3 mA shock)	2.4	2.8	3.7	-1.6	1.7	1.9	-1.9	1.6	1.0	-1.8
Compulsive drug intake	2.4	2.4	3.7	1.6	-1.9	-1.9	1.8	-0.4	1.7	1.0
One hour access (shock baseline)	3.9	4.5	6.8	-2.3	2.5	2.6	-2.5	1.6	-0.2	-2.2
Social response proportion	2.9	3.2	6.8	-2.0	1.7	1.4	-1.5	1.9	-2.6	0.9
Social responses	1.7	2.2	4.3	-1.9	1.6	1.1	-1.3	2.1	-1.4	0.6
Social time	1.1	1.4	3.3	-1.1	0.8	1.2	-1.8	0.2	-1.8	-0.1
Soleus weight	0.2	0.7	2.3	-1.1	0.3	0.5	-0.6	-0.2	-1.5	0.9
Bone: stiffness	2.2	3.4	10.6	-1.9	1.8	1.8	-1.4	0.9	-3.3	0.1
Tibialis anterior weight	0.3	0.9	4.3	0.3	-0.7	-0.6	0.6	-0.6	-0.7	2.1
Time to tail flick, vehicle, before self-admin	2.9	3.0	8.0	-1.7	1.4	2.1	-1.6	0.9	-0.4	-2.8
Time to tail flick, vehicle, after self-admin	1.2	1.3	2.3	1.3	-0.8	-1.1	1.4	-1.5	-0.2	1.1
Time to tail flick, test, before self-admin	0.2	0.2	0.9	-0.4	0.4	0.4	-0.9	-0.1	0.0	-0.2
Time to tail flick, test, after self-admin	0.1	0.1	0.3	-0.1	-0.4	0.3	-0.5	-0.3	0.5	-0.2
Delta time to tail flick, vehicle, before/after SA	3.8	3.8	6.2	2.1	-1.7	-2.3	2.1	-1.8	0.2	2.5
Delta time to tail flick, test, before/after SA	0.3	0.3	0.7	0.6	-0.8	-0.4	0.7	-0.1	0.4	0.1
Tibia length	8.8	24.8	33.8	-5.8	5.7	5.5	-5.2	5.6	-3.2	-3.1
Ambulatory time before self-admin	0.6	0.7	1.0	-1.0	1.0	0.8	-1.0	0.9	-0.3	-0.2
Ambulatory time after self-admin	1.0	1.1	2.6	-1.4	1.2	0.7	-0.8	1.6	-0.8	0.3
Bone: tissue strength	0.5	0.5	1.3	-0.5	0.7	0.6	-0.8	-0.5	-1.1	-0.1
Total heroin consumption	0.3	0.4	0.9	0.3	-0.7	-0.8	1.0	0.0	0.3	0.8
Bone: trabecular number	0.4	0.6	1.9	0.5	-1.3	-0.4	0.5	-1.4	0.2	0.2
Bone: trabecular spacing	0.5	0.6	2.4	0.5	-0.4	-0.6	0.5	0.9	1.5	-0.2
Bone: trabecular thickness	0.6	0.7	3.1	-0.6	0.8	0.7	-0.6	0.1	-1.7	0.2
Bone: trabecular tissue density	0.0	0.0	0.1	-0.2	0.1	0.1	-0.2	0.0	0.1	-0.3
Water consumed over 24 hours	1.0	1.2	2.5	-0.6	1.2	1.1	-1.1	-0.3	-1.6	-1.2
Number of responses in last shaping day	0.9	0.9	2.4	-0.7	0.9	1.1	-1.6	0.6	0.4	-0.9