Hub : Genes

Nckipsd

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA mRNA stability Nckipsd 0.1 0.07 1.5e-04 0.03 0.03 0.04 0.04 6.5e-03 8.8e-03 2.7e-03 5.6e-03
2 Brain mRNA stability Nckipsd 0.07 0.05 8.5e-06 0.05 0.05 0.06 0.06 2.1e-05 2.5e-05 3.9e-06 6.8e-06
3 NAcc gene expression Nckipsd 0.07 0.06 7.3e-07 0.04 0.04 0.04 0.04 2.1e-07 9.4e-07 7.2e-07 4.4e-07
4 PL gene expression Nckipsd 0.17 0.11 1.0e-11 0.1 0.09 0.08 0.09 1.2e-10 6.1e-10 1.9e-09 2.1e-10
5 IC gene expression Nckipsd 0.21 0.12 9.6e-06 0.08 0.11 0.11 0.08 3.5e-04 2.5e-05 1.8e-05 3.3e-04
6 pVTA isoform ratio NM_001393927.1 0.11 0.07 1.6e-06 0.06 0.06 0.06 0.06 7.0e-06 3.1e-05 5.9e-06 6.8e-06
7 Brain gene expression Nckipsd 0.15 0.11 8.8e-08 0.08 0.08 0.09 0.08 4.0e-08 1.1e-07 2.5e-08 6.4e-08
8 pVTA mRNA stability Nckipsd 0.05 0.04 3.4e-04 0.03 0.03 0.03 0.03 4.2e-03 1.3e-03 1.4e-03 1.4e-03
9 PL mRNA stability Nckipsd 0.06 0.04 1.0e-06 0.06 0.04 0.06 0.06 1.7e-07 9.4e-06 9.8e-07 2.8e-07
10 NAcc isoform ratio XM_008766509.4 0.04 0.03 9.7e-05 0.03 0.02 0.03 0.03 2.6e-05 6.8e-04 6.4e-05 5.7e-05
11 NAcc isoform ratio NM_001393927.1 0.03 0.02 3.0e-04 0.02 0.02 0.03 0.02 1.1e-04 3.3e-04 2.3e-05 1.5e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.10.20.70.1-0.1-0.0-0.10.6-0.4-0.3-0.10.10.8-0.8
Area under the delay curve1.51.82.81.31.21.41.51.7-1.40.91.21.21.3-1.5
BMI with tail0.10.40.8-0.6-0.3-0.8-0.8-0.50.7-0.9-0.5-0.3-0.60.5
BMI without tail0.61.73.2-1.5-1.4-1.4-1.3-1.11.2-1.8-1.4-1.3-1.00.6
Body weight4.720.424.1-4.7-4.4-4.9-4.9-4.54.8-4.5-4.5-4.2-4.43.6
Weight adjusted by age0.00.00.1-0.3-0.20.20.0-0.40.1-0.0-0.1-0.3-0.10.3
Bone surface0.10.20.40.50.50.40.40.5-0.50.20.40.50.6-0.5
Bone volume0.10.20.40.30.30.20.20.5-0.50.00.20.40.7-0.6
Breakpoint value in progressive ratio session0.10.10.10.30.20.20.30.4-0.30.10.20.20.2-0.3
Number of licking bursts0.20.30.90.40.70.70.7-0.2-0.20.90.70.4-0.20.5
Context. condit. distance diff. score0.00.00.1-0.1-0.0-0.0-0.0-0.20.10.0-0.0-0.1-0.20.2
Locomotion velocity, session 10.10.10.30.20.10.00.00.5-0.3-0.00.10.20.5-0.5
Locomotion distance, session 10.91.12.4-1.0-1.1-1.4-1.4-0.60.9-1.6-1.2-0.9-0.40.2
Locomotion velocity, session 20.30.30.50.60.70.40.40.7-0.50.40.60.70.6-0.5
Locomotion distance, session 20.10.20.60.30.1-0.2-0.20.7-0.3-0.40.00.40.7-0.8
Locomotion velocity, session 30.20.20.8-0.2-0.3-0.6-0.50.30.1-0.9-0.4-0.10.3-0.5
Locomotion distance, session 31.11.21.81.11.10.90.91.3-1.20.61.01.21.4-1.2
Stereotopy head waving bouts, day 30.20.21.0-0.20.0-0.0-0.0-0.70.50.40.0-0.2-0.81.0
Stereotopy head waving duration, day 30.30.40.8-0.6-0.5-0.3-0.4-0.80.7-0.0-0.4-0.6-0.90.9
Locomotion velocity, session 70.10.10.4-0.3-0.5-0.3-0.30.20.0-0.6-0.4-0.30.3-0.5
Locomotion distance, session 71.21.52.61.31.11.01.11.5-1.40.81.01.21.6-1.4
Stereotopy head waving bouts, day 70.00.00.0-0.0-0.1-0.0-0.10.1-0.0-0.1-0.1-0.10.1-0.2
Stereotopy head waving duration, day 70.40.40.6-0.7-0.8-0.7-0.7-0.50.6-0.8-0.7-0.7-0.50.3
Locomotion velocity, session 80.20.31.0-0.4-0.5-0.8-0.80.00.4-1.0-0.6-0.3-0.1-0.2
Locomotion distance, session 80.20.41.4-0.4-0.5-0.8-0.80.20.2-1.2-0.6-0.20.2-0.6
Degree of sensitization distance1.01.01.4-1.1-1.2-0.9-0.9-1.11.0-0.8-1.0-1.1-0.90.8
Degree of sensitization stereotypy0.10.10.3-0.2-0.5-0.3-0.40.20.1-0.5-0.4-0.30.2-0.4
Conditioned locomotion3.43.94.82.01.82.02.02.2-2.21.81.81.82.2-1.9
Cocaine response after cond. corrected0.60.72.0-0.7-0.4-0.5-0.5-1.21.0-0.0-0.4-0.7-1.41.4
Cocaine response after cond. not corrected2.22.64.4-1.6-1.3-1.4-1.4-2.01.8-1.0-1.3-1.5-2.11.9
Cocaine response before conditioning1.11.32.3-1.2-1.2-1.4-1.4-0.91.1-1.5-1.3-1.0-0.70.5
Saline control response0.70.91.6-1.0-1.3-1.0-1.0-0.70.8-1.2-1.1-1.0-0.50.3
Bone: connectivity density0.50.82.00.70.40.70.71.1-1.10.30.50.61.4-1.3
Bone: cortical apparent density0.20.30.50.50.40.40.40.6-0.60.30.40.50.7-0.6
Bone: cortical area0.20.20.70.40.60.50.5-0.1-0.10.80.60.4-0.40.5
Bone: cortical porosity0.30.41.30.3-0.00.50.50.8-0.7-0.00.10.21.0-1.1
Bone: cortical porosity0.30.31.20.3-0.10.40.40.7-0.70.00.10.10.9-1.1
Bone: cortical thickness0.30.51.6-0.4-0.1-0.3-0.3-1.00.80.2-0.1-0.3-1.21.3
Bone: cortical thickness0.00.00.10.10.20.10.1-0.10.00.30.20.0-0.20.2
Bone: cortical tissue density0.20.30.50.50.40.40.40.6-0.60.30.40.50.7-0.6
Condit. Reinf. active minus inactive responses0.10.10.2-0.1-0.2-0.2-0.1-0.40.30.1-0.2-0.2-0.40.5
Condit. Reinf. active-inactive response ratio0.30.30.8-0.4-0.4-0.4-0.4-0.70.6-0.0-0.4-0.4-0.80.9
Condit. Reinf. active responses0.00.00.10.00.10.20.2-0.20.00.40.20.0-0.30.3
Condit. Reinf. inactive responses0.40.50.70.60.80.80.80.6-0.70.60.80.70.6-0.6
Incentive salience index mean0.00.10.10.30.30.20.30.1-0.20.40.30.30.10.0
Condit. Reinf. lever presses1.11.62.01.41.41.21.31.2-1.31.21.31.41.1-0.9
Condit. Reinf. active minus inactive responses1.31.72.2-1.2-1.2-1.5-1.5-1.41.4-1.4-1.3-1.1-1.21.2
Condit. Reinf. active-inactive response ratio1.31.52.0-1.2-1.1-1.4-1.4-1.31.3-1.3-1.2-1.0-1.21.2
Condit. Reinf. active responses1.21.62.1-1.2-1.2-1.4-1.4-1.31.4-1.3-1.3-1.1-1.21.1
Condit. Reinf. inactive responses0.10.10.10.30.30.30.30.3-0.30.40.30.30.3-0.2
Condit. Reinf. lever presses1.72.43.3-1.5-1.5-1.8-1.8-1.51.6-1.7-1.6-1.3-1.31.2
Condit. Reinf. lever reinforcers received1.52.12.6-1.4-1.4-1.6-1.6-1.51.5-1.4-1.4-1.3-1.41.2
Conditioned reinforcement - actives1.72.84.41.81.92.11.91.5-1.71.71.81.71.2-0.9
Conditioned reinforcement - inactives1.92.95.01.92.21.71.71.3-1.52.22.01.81.0-0.4
Conditioned locomotion0.40.61.10.70.60.80.71.1-0.90.40.60.60.9-0.9
Patch foraging indifference point 0 sec1.12.03.3-1.6-1.8-1.5-1.5-1.01.2-1.6-1.6-1.7-0.80.4
Patch foraging indifference point AUC0.00.10.2-0.0-0.3-0.3-0.10.30.0-0.5-0.2-0.00.2-0.5
Delay disc. indifference point, 0s delay0.00.00.0-0.1-0.1-0.00.00.00.0-0.0-0.0-0.1-0.1-0.0
Delay disc. indifference point, 16s delay1.01.12.01.00.91.01.01.4-1.00.70.90.91.0-1.3
Delay disc. indifference point, 2s delay0.20.30.50.40.40.60.60.5-0.60.30.40.30.7-0.5
Delay disc. indifference point, 24s delay1.01.11.91.00.91.11.11.4-1.10.80.90.91.1-1.3
Delay disc. indifference point, 4s delay1.31.42.11.21.21.31.41.2-1.21.01.21.11.0-0.9
Delay disc. indifference point, 8s delay1.82.13.01.51.41.51.51.7-1.51.11.31.41.4-1.5
Indifference point function ln k0.30.50.80.80.90.60.30.8-0.70.60.70.90.9-0.6
Indifference point function log k0.30.50.80.80.90.60.30.8-0.70.60.70.90.9-0.6
Patch foraging total patch changes 0 sec1.22.23.4-1.7-1.8-1.6-1.5-1.21.4-1.6-1.7-1.7-1.00.6
Patch foraging total patch changes 12 sec1.01.31.7-1.3-1.3-1.2-1.2-1.01.1-1.1-1.2-1.3-0.90.6
Patch foraging total patch changes 18 sec1.52.33.9-1.6-2.0-1.7-1.6-1.11.5-1.7-1.7-1.7-1.20.6
Patch foraging total patch changes 24 sec1.72.94.2-1.7-1.9-2.0-1.9-1.61.7-1.8-1.8-1.6-1.31.2
Patch foraging total patch changes 6 sec0.20.40.8-0.6-0.9-0.6-0.40.00.2-0.9-0.8-0.70.2-0.5
Patch foraging time to switch 0 sec0.10.30.70.40.60.70.70.1-0.40.90.60.40.10.2
Patch foraging water rate 0 sec0.20.40.7-0.6-0.6-0.5-0.5-0.70.7-0.5-0.5-0.6-0.80.6
Patch foraging water rate 12 sec0.10.30.4-0.5-0.5-0.6-0.7-0.30.6-0.5-0.5-0.4-0.60.3
Patch foraging water rate 18 sec0.10.20.5-0.3-0.1-0.2-0.1-0.60.5-0.2-0.1-0.2-0.70.7
Patch foraging water rate 24 sec0.91.22.1-1.1-1.0-0.9-0.8-1.41.2-0.9-1.0-0.9-1.41.3
Patch foraging water rate 6 sec0.30.50.7-0.6-0.6-0.7-0.8-0.70.8-0.8-0.7-0.6-0.70.6
Seeking ratio, delayed vs. immediate footshock1.92.43.41.41.41.81.81.5-1.71.31.41.41.6-1.4
Distance traveled before self-admin0.30.51.00.70.90.60.80.3-0.51.00.80.70.30.0
Distance traveled after self-admin0.20.30.50.60.70.50.70.3-0.40.70.60.60.20.0
Extensor digitorum longus weight0.10.40.70.60.90.70.70.4-0.50.80.80.60.2-0.1
Bone: elastic displacement0.10.10.4-0.2-0.1-0.2-0.2-0.50.40.0-0.1-0.2-0.60.6
Bone: elastic work0.40.61.1-0.7-0.5-0.6-0.7-1.00.9-0.5-0.5-0.6-1.11.0
Bone: endosteal estimation0.00.10.1-0.3-0.4-0.1-0.10.0-0.0-0.3-0.3-0.30.2-0.3
Bone: endosteal perimeter1.12.32.71.51.51.51.51.6-1.61.41.51.51.5-1.4
Epididymis fat weight0.20.81.1-1.0-0.9-0.8-0.9-1.01.0-0.8-0.9-0.8-1.10.9
Delta time in closed arm before/after self-admin0.60.60.80.80.80.60.50.8-0.70.70.70.90.9-0.8
Delta time in open arm before/after self-admin0.30.30.4-0.6-0.5-0.4-0.3-0.60.5-0.5-0.5-0.6-0.60.5
Diff in mean of infusions in LGA sessions0.30.41.6-0.4-0.1-0.4-0.1-1.10.60.1-0.1-0.3-0.91.3
Delay discount exponential model param1.71.93.0-1.4-1.3-1.5-1.5-1.71.5-1.0-1.2-1.2-1.41.5
Extinction: sum of active levers before priming0.10.10.20.1-0.00.30.20.4-0.2-0.00.10.10.1-0.5
Active lever presses in extinction session 60.20.20.5-0.3-0.5-0.6-0.50.40.1-0.5-0.4-0.30.3-0.7
Bone: final force1.52.33.5-1.6-1.3-1.4-1.4-1.91.7-1.2-1.3-1.4-1.91.7
Bone: final moment1.62.64.1-1.7-1.4-1.5-1.5-2.01.8-1.2-1.4-1.5-2.01.8
Food consumed during 24 hour testing period1.21.72.1-1.3-1.3-1.4-1.4-1.31.4-1.3-1.3-1.2-1.31.1
Glucose0.81.32.2-1.2-1.3-1.3-1.3-0.91.1-1.5-1.3-1.0-0.80.4
Heart weight2.13.35.8-1.7-1.3-1.7-1.6-2.32.1-1.1-1.4-1.5-2.42.3
Delay discount hyperbolic model param1.92.13.0-1.5-1.4-1.6-1.6-1.71.5-1.1-1.3-1.3-1.41.5
Intermittent access intake day 1-15 change0.91.82.41.41.51.41.31.4-1.31.61.41.31.1-0.9
Intermittent access intake escalation1.12.33.31.61.81.61.51.5-1.41.81.61.51.2-0.9
Intermittent access intake escalation 20.40.51.10.80.90.70.50.6-0.51.10.80.70.3-0.2
Intermitt. access day 1 inactive lever presses0.00.10.20.30.40.40.3-0.1-0.10.50.30.3-0.20.4
Intermitt. access day 15 inactive lever presses0.71.52.51.41.61.31.40.9-1.11.51.41.40.6-0.2
Intermitt. access escalation Index0.10.10.50.1-0.1-0.00.10.4-0.3-0.3-0.10.00.7-0.7
Intermittent access day 1 total infusions0.20.40.70.60.60.80.70.7-0.60.50.60.50.4-0.5
Intermittent access day 15 total infusions1.72.63.21.71.71.81.61.8-1.61.71.71.51.3-1.2
Intermittent access terminal intake (last 3 days)1.41.82.71.41.31.51.41.6-1.41.21.31.21.2-1.2
Intermittent access total infusions1.82.12.91.51.51.71.61.6-1.51.41.51.31.1-1.1
Intermittent access day 1 locomotion0.10.10.2-0.2-0.4-0.1-0.20.20.1-0.4-0.3-0.3-0.0-0.3
Intermittent access day 15 total locomotion0.71.22.21.11.01.10.81.5-1.20.90.91.01.3-1.3
Intermittent access total locomotion1.41.73.01.21.11.31.01.7-1.40.91.11.11.6-1.6
Intermittent access standard deviation0.00.10.30.10.30.20.1-0.00.10.50.20.0-0.40.4
Left kidney weight0.63.04.1-1.9-1.8-2.0-1.9-1.51.8-1.9-1.8-1.7-1.51.0
Right kidney weight0.31.31.9-1.3-1.3-1.3-1.2-0.91.1-1.4-1.2-1.2-1.00.5
Cocaine induced anxiety0.30.50.8-0.8-0.7-0.4-0.4-0.90.6-0.6-0.6-0.8-0.80.8
Post-drug Anxiety0.10.10.2-0.3-0.30.00.0-0.50.2-0.2-0.2-0.3-0.30.4
Baseline Anxiety0.40.40.60.80.60.60.50.7-0.70.50.60.70.8-0.6
Tail length4.618.021.6-4.6-4.7-4.3-4.3-4.34.4-4.2-4.4-4.4-4.03.0
Length with tail8.536.942.5-6.4-6.1-6.3-6.4-6.36.5-5.5-6.0-5.9-6.25.0
Length without tail6.721.525.9-4.7-4.5-4.9-5.1-4.85.1-4.1-4.5-4.3-4.94.0
Times rat made contact with spout0.70.81.1-0.9-0.9-0.9-0.9-1.01.0-0.7-0.8-0.8-1.00.9
Lifetime Intake2.32.84.31.71.71.81.62.1-1.71.61.61.51.5-1.6
Liver weight, left0.61.01.4-1.1-1.2-1.1-1.1-0.81.0-1.2-1.1-1.0-0.80.5
Liver weight, right1.52.73.7-1.8-1.9-1.7-1.7-1.51.6-1.8-1.7-1.7-1.40.9
Locomotor activity5.48.410.0-3.2-3.1-3.1-3.1-2.93.0-2.9-3.0-2.9-2.62.1
Locomotor testing distance3.76.78.0-2.8-2.8-2.7-2.8-2.62.7-2.5-2.7-2.6-2.41.9
Locomotor testing rearing0.00.00.1-0.2-0.2-0.1-0.2-0.30.20.0-0.1-0.2-0.20.3
Locomotion in novel chamber0.10.10.40.30.40.20.20.2-0.20.60.30.20.1-0.1
Locomotion in novel chamber post-restriction0.30.51.1-0.7-0.7-1.0-0.9-0.20.7-0.7-0.7-0.7-0.4-0.2
Fecal boli incidents, locomotor time 10.60.91.3-1.1-0.9-0.6-0.7-1.11.0-0.5-0.8-1.1-1.10.9
Change in fecal boli incidents, locomotor task0.10.10.50.60.40.20.20.4-0.30.10.30.70.4-0.1
Time >=10cm from walls, locomotor time 10.40.41.10.60.50.30.21.0-0.70.40.50.50.9-1.0
Bouts of movement, locomotor time 10.10.10.4-0.5-0.4-0.2-0.1-0.60.3-0.3-0.3-0.4-0.30.5
Total resting periods, locomotor time 10.10.10.2-0.3-0.2-0.2-0.1-0.40.2-0.2-0.2-0.3-0.20.3
Rest time, locomotor task time 10.40.50.70.80.90.80.70.6-0.60.80.80.80.4-0.4
Distance moved, locomotor task time 10.91.41.8-1.1-1.1-1.3-1.3-1.41.2-1.0-1.1-1.0-1.01.2
Vertical activity count, locomotor time 10.51.21.9-1.2-1.1-1.1-1.0-1.41.1-1.0-1.1-1.1-1.11.0
Time >=10cm from walls, locomotor time 20.91.42.0-1.3-1.2-1.3-1.4-0.91.3-1.0-1.1-1.3-1.20.6
Bouts of movement, locomotor time 20.10.10.20.30.40.30.20.1-0.30.30.30.40.20.3
Total resting periods, locomotor time 20.10.20.40.60.60.60.50.3-0.50.50.50.70.40.1
Rest time, locomotor task time 20.00.00.10.10.10.30.3-0.1-0.00.10.20.2-0.20.1
Distance moved, locomotor task time 20.70.81.5-1.0-0.9-1.2-1.2-0.60.9-0.7-0.9-1.0-0.50.4
Vertical activity count, locomotor time 20.00.00.1-0.2-0.2-0.3-0.3-0.00.0-0.1-0.2-0.30.2-0.2
Light reinforcement 10.51.11.5-1.2-1.2-0.9-1.1-1.01.1-1.0-1.1-1.2-1.00.6
Light reinforcement 20.20.30.90.30.20.30.20.7-0.6-0.10.20.30.8-0.9
Bone: marrow area0.00.10.2-0.3-0.4-0.1-0.1-0.00.0-0.4-0.3-0.30.1-0.3
Bone: maximum diameter0.30.51.10.70.90.80.80.3-0.51.00.90.70.10.1
Bone: maximum force0.81.41.9-1.3-1.1-1.1-1.1-1.41.3-1.0-1.1-1.2-1.41.1
Bone: maximum moment0.91.52.2-1.3-1.1-1.1-1.1-1.41.4-1.0-1.1-1.2-1.51.2
Mean time between licks in bursts0.82.12.51.61.61.41.41.5-1.51.41.51.51.4-1.1
Mean num. licks in bursts0.60.91.9-0.9-1.2-1.2-1.2-0.40.7-1.4-1.2-0.9-0.3-0.1
Cd content in liver0.20.20.40.40.20.20.20.6-0.50.10.20.30.7-0.7
Co content in liver1.51.72.51.51.41.41.41.2-1.31.61.41.31.0-0.7
Cu content in liver4.45.26.4-2.5-2.4-2.2-2.2-2.52.4-2.2-2.2-2.4-2.31.8
Fe content in liver1.31.52.4-1.2-1.2-1.0-1.0-1.61.3-0.8-1.1-1.3-1.41.4
K content in liver0.30.30.5-0.7-0.6-0.5-0.5-0.50.6-0.7-0.5-0.5-0.50.3
Mg content in liver0.70.70.90.80.90.80.80.8-0.80.50.91.00.8-0.7
Mn content in liver0.10.10.40.1-0.2-0.3-0.30.4-0.1-0.6-0.20.20.5-0.7
Na content in liver0.50.61.1-0.9-1.0-0.6-0.6-0.70.7-0.7-0.8-0.9-0.70.4
Rb content in liver0.70.81.6-0.9-0.8-0.4-0.4-1.20.9-0.1-0.7-1.1-1.21.2
Se content in liver0.10.10.2-0.2-0.2-0.4-0.4-0.30.2-0.5-0.2-0.1-0.10.2
Sr content in liver0.20.20.30.30.3-0.3-0.30.5-0.2-0.50.10.50.6-0.6
Zn content in liver2.22.53.2-1.8-1.8-1.6-1.6-1.51.6-1.7-1.6-1.6-1.50.9
Bone: minimum diameter0.61.01.31.11.11.11.10.9-1.01.01.11.10.9-0.7
Time in familiar zone, hab. session 11.51.52.81.21.31.51.50.9-1.21.71.41.10.8-0.4
Time in novel zone, hab. session 10.80.81.1-0.9-0.9-1.0-1.1-0.80.9-1.1-0.9-0.8-0.70.6
Total zone transitions, hab. session 10.50.72.0-0.7-0.9-1.2-1.2-0.20.6-1.4-1.0-0.6-0.1-0.2
Total locomotion distance, hab. session 10.30.40.9-0.6-0.7-0.8-0.8-0.40.6-0.9-0.7-0.5-0.30.1
Locomotion velocity, hab. session 10.30.51.1-0.6-0.7-0.9-0.9-0.30.6-1.1-0.8-0.5-0.20.1
Time in familiar zone, hab. session 20.60.61.40.81.01.01.00.3-0.61.21.00.80.10.1
Time in novel zone, hab. session 20.10.10.1-0.2-0.3-0.2-0.30.2-0.0-0.3-0.3-0.20.3-0.3
Total zone transitions, hab. session 20.10.10.5-0.2-0.2-0.6-0.6-0.10.3-0.7-0.3-0.0-0.00.0
Total locomotion distance, hab. session 20.40.51.1-0.7-0.7-0.9-0.9-0.50.7-1.0-0.8-0.6-0.50.3
Locomotion velocity, hab. session 20.30.41.0-0.6-0.7-0.8-0.8-0.40.6-1.0-0.7-0.5-0.40.2
Novel to familiar place preference ratio0.70.71.9-0.9-1.2-0.8-0.8-0.10.3-1.4-1.1-1.00.2-0.7
Novelty place preference0.70.81.9-0.9-1.3-0.7-0.8-0.00.3-1.4-1.1-1.00.3-0.8
Time in novel zone, NPP test0.80.91.9-1.1-1.4-0.8-0.8-0.20.4-1.4-1.2-1.10.1-0.5
Total zone transitions, NPP test2.43.47.1-1.9-1.9-2.3-2.3-1.21.7-2.7-2.0-1.6-1.10.5
Total locomotion distance, NPP test1.21.72.7-1.3-1.3-1.5-1.5-1.01.3-1.6-1.4-1.2-1.00.7
Locomotion velocity, NPP test1.31.93.3-1.4-1.4-1.6-1.6-1.01.3-1.8-1.5-1.2-1.00.6
Intraocular pressure0.81.21.8-1.2-1.4-0.9-0.9-1.11.1-0.9-1.1-1.3-1.10.8
Delta distance traveled before/after self-admin0.10.10.3-0.4-0.4-0.2-0.2-0.20.2-0.5-0.4-0.4-0.2-0.0
Delta ambulatory time before/after self-admin0.91.11.6-1.2-1.2-1.0-0.9-0.91.0-1.3-1.1-1.2-0.90.5
Parametrial fat weight0.71.82.5-1.5-1.4-1.4-1.6-1.41.3-1.4-1.4-1.3-1.01.0
Pavlov. Cond. lever latency4.15.27.0-2.5-2.6-2.3-2.3-2.22.3-2.2-2.4-2.5-2.01.5
Pavlov. Cond. magazine entry latency7.09.011.53.23.43.23.12.9-3.03.23.23.12.5-1.9
Pavlov. Cond. change in total contacts1.61.72.51.51.51.41.41.1-1.21.61.41.40.9-0.5
Pavlov. Cond. index score5.87.39.93.03.12.92.92.5-2.62.93.02.92.2-1.6
Pavlov. Cond. latency score5.87.49.73.03.12.82.82.5-2.72.82.92.92.3-1.7
Pavlov. Cond. lever contacts2.22.73.81.82.01.61.61.5-1.61.61.81.91.4-1.0
Pavlov. Cond. magazine entry number7.18.911.5-3.2-3.4-3.2-3.2-2.82.9-3.3-3.2-3.1-2.41.8
Pavlov. Cond. intertrial magazine entries0.30.40.5-0.7-0.7-0.5-0.5-0.60.6-0.6-0.6-0.7-0.60.4
Pavlov. Cond. lever-magazine prob. diff.5.16.38.82.83.02.62.72.2-2.42.82.82.71.9-1.3
Pavlov. Cond. response bias6.27.610.53.03.22.92.92.5-2.73.03.03.02.2-1.6
Pavlov. Cond. lever latency0.40.60.90.70.71.01.00.7-0.81.00.80.60.6-0.5
Pavlov. Cond. magazine entry latency0.10.20.30.40.50.30.30.4-0.40.20.40.50.4-0.3
Pavlov. Cond. change in total contacts1.82.83.5-1.7-1.6-1.9-1.9-1.71.8-1.7-1.7-1.5-1.61.4
Pavlov. Cond. index score0.10.20.3-0.3-0.2-0.5-0.5-0.40.4-0.5-0.4-0.2-0.40.4
Pavlov. Cond. latency score0.10.10.2-0.2-0.1-0.4-0.4-0.30.3-0.4-0.2-0.1-0.20.3
Pavlov. Cond. lever contacts0.60.91.4-0.9-1.0-1.2-1.2-0.80.9-1.2-1.0-0.8-0.70.5
Pavlov. Cond. magazine entry number0.20.20.3-0.5-0.6-0.4-0.4-0.50.5-0.4-0.5-0.5-0.40.4
Pavlov. Cond. intertrial magazine entries0.50.81.41.00.91.11.10.8-0.91.20.90.80.7-0.4
Pavlov. Cond. lever-magazine prob. diff.0.10.10.2-0.3-0.2-0.5-0.5-0.30.4-0.5-0.3-0.1-0.30.3
Pavlov. Cond. response bias0.00.00.1-0.1-0.0-0.3-0.3-0.00.2-0.3-0.20.0-0.10.0
Time in closed arm before self-admin0.50.61.1-0.9-0.9-0.9-1.0-0.50.8-0.8-0.9-0.9-0.60.3
Time in closed arm after self-admin0.30.30.50.60.70.50.30.5-0.50.70.60.70.4-0.3
Time in open arm before self-admin0.60.61.20.70.81.11.00.6-0.80.80.80.80.7-0.6
Time in open arm after self-admin0.30.30.90.30.20.60.60.7-0.60.00.30.30.7-1.0
Bone: periosteal estimation0.00.00.0-0.10.00.10.1-0.20.10.10.0-0.1-0.20.2
Bone: periosteal perimeter0.91.51.91.31.31.31.41.2-1.31.31.31.21.1-0.9
Bone: post-yield work0.00.00.1-0.2-0.1-0.1-0.10.00.1-0.2-0.1-0.10.0-0.2
Progressive ratio test 1 active lever presses0.20.21.10.2-0.00.10.10.9-0.4-0.10.00.00.6-1.0
Progressive ratio test 1 breakpoint0.20.21.10.2-0.00.10.10.9-0.4-0.10.00.00.6-1.1
Progressive ratio test 1 inactive lever presses0.30.50.80.80.80.70.70.7-0.50.90.80.70.3-0.2
Progressive ratio test 2 active lever presses1.72.03.01.51.51.71.61.5-1.41.41.51.31.0-1.0
Progressive ratio test 2 breakpoint1.72.03.01.51.51.71.61.5-1.41.41.51.31.0-0.9
Progressive ratio test 2 inactive lever presses1.82.94.11.82.02.01.91.5-1.52.01.91.71.0-0.7
Incentive Sensitization - Responses1.62.33.71.61.81.91.81.2-1.31.81.71.60.7-0.4
Incentive Sensitization - Breakpoint1.82.33.81.71.81.91.81.2-1.31.81.71.60.7-0.4
Sum of active levers in priming session hrs 5-60.10.10.4-0.2-0.4-0.1-0.10.4-0.1-0.5-0.3-0.20.3-0.7
Progressive ratio2.64.05.4-2.3-2.3-2.0-2.0-1.82.0-2.1-2.2-2.2-1.81.1
Food seeking constrained by brief footshock1.21.52.21.41.40.91.01.5-1.11.41.31.31.1-1.1
Seeking ratio, punishment vs. effort4.46.48.92.93.02.42.52.3-2.42.82.82.82.1-1.4
Retroperitoneal fat weight1.35.57.3-2.5-2.4-2.5-2.7-2.32.5-2.3-2.4-2.3-2.11.7
Reaction time number correct0.51.01.51.11.11.11.01.1-0.91.21.01.00.6-0.7
Reaction time mean minus median0.10.20.4-0.5-0.4-0.5-0.3-0.50.3-0.6-0.4-0.4-0.20.3
Reaction time mean minus median AUC0.20.40.7-0.7-0.7-0.7-0.6-0.60.5-0.8-0.6-0.7-0.40.3
Reaction time num false alarms0.20.30.40.60.50.60.60.6-0.60.70.50.50.6-0.6
Reaction time num false alarms AUC0.10.10.20.20.10.30.30.4-0.40.30.20.10.5-0.5
Reaction time trials correct on left0.51.01.51.11.11.11.01.1-0.91.21.01.00.6-0.7
Reaction time trials on left0.51.01.51.11.11.11.01.1-0.91.21.01.00.7-0.7
Reaction time mean0.00.00.20.0-0.10.10.10.2-0.30.00.0-0.00.4-0.3
Reaction time mean AUC0.10.10.40.1-0.00.20.10.4-0.40.00.00.00.6-0.5
Median of all reaction times0.10.20.50.30.10.40.30.5-0.50.30.20.20.7-0.6
Reaction time omissions0.10.10.40.20.00.30.40.5-0.50.40.20.10.6-0.6
Reaction time false alarm rate0.00.00.0-0.1-0.2-0.1-0.0-0.1-0.0-0.1-0.1-0.20.2-0.1
Reaction time premature initiation rate2.23.04.2-1.9-2.0-2.0-1.9-1.41.6-2.1-2.0-1.8-1.20.8
Reaction time premature initiations0.71.21.7-1.2-1.3-1.3-1.2-0.71.0-1.3-1.3-1.1-0.70.4
Std. dev. reaction times0.10.20.4-0.4-0.6-0.4-0.3-0.20.1-0.6-0.5-0.50.2-0.2
Reaction time trials completed0.51.01.51.11.11.11.01.1-0.91.21.01.00.7-0.7
Reaction time trials AUC0.71.31.91.31.21.31.11.2-1.01.41.21.20.8-0.8
Run reversals in cocaine runway, females1.81.82.81.61.71.00.91.3-1.31.61.51.61.4-0.8
Run reversals in cocaine runway, males1.41.41.9-1.4-1.2-1.0-1.0-1.31.3-0.9-1.1-1.3-1.31.1
Latency to leave start box in cocaine runway0.50.51.4-0.7-0.6-0.7-0.5-0.70.9-0.5-0.6-0.5-1.20.8
Latency to leave start box in cocaine runway, F1.01.22.2-1.0-0.8-1.1-0.9-1.31.3-0.5-0.8-0.9-1.51.4
Latency to leave start box in cocaine runway, M0.40.30.60.60.50.70.70.8-0.50.30.50.60.3-0.7
Std. dev. time between licks in bursts4.15.68.12.62.82.62.61.9-2.22.82.72.51.6-1.0
Total sessions with >9 infusions0.50.61.00.90.90.80.70.8-0.51.00.90.80.1-0.3
Short access day 1 total inactive lever presses4.66.07.52.72.72.52.42.5-2.42.62.62.62.1-1.7
Short access day 10 total inactive lever presses0.30.82.9-0.5-0.2-0.4-0.3-1.40.90.0-0.3-0.4-1.31.7
Short access day 1 total infusions3.24.35.62.22.12.22.12.4-2.12.02.12.01.8-1.8
Short access day 10 total infusions2.83.55.72.01.81.81.72.4-1.91.61.81.81.9-1.9
Short access total infusions4.15.37.92.42.32.22.12.8-2.32.12.22.22.3-2.2
Short access day 1 locomotion0.40.50.80.80.90.80.70.6-0.60.80.80.80.4-0.2
Short access day 10 total locomotion0.10.20.70.1-0.1-0.1-0.20.7-0.3-0.1-0.10.00.7-0.9
Short access total locomotion0.10.10.50.20.10.10.10.7-0.3-0.00.10.10.5-0.7
One hour access (0.3 mA shock)1.41.63.41.21.01.11.01.9-1.30.81.01.01.4-1.7
Compulsive drug intake1.21.42.51.21.20.90.91.3-1.31.01.11.21.6-1.2
One hour access (shock baseline)0.30.40.80.60.60.90.80.9-0.60.50.60.50.4-0.6
Social response proportion0.20.20.4-0.4-0.6-0.6-0.6-0.40.4-0.4-0.5-0.5-0.20.2
Social responses0.40.50.9-0.8-0.9-0.6-0.6-0.70.6-1.0-0.8-0.8-0.50.4
Social time0.30.40.90.60.90.80.70.4-0.51.00.80.60.2-0.1
Soleus weight4.212.214.0-3.7-3.5-3.6-3.6-3.73.7-3.4-3.4-3.4-3.52.8
Bone: stiffness0.20.30.4-0.6-0.6-0.5-0.5-0.60.6-0.5-0.5-0.6-0.60.4
Tibialis anterior weight0.00.20.5-0.3-0.0-0.2-0.2-0.50.5-0.0-0.1-0.3-0.70.7
Time to tail flick, vehicle, before self-admin1.11.21.7-1.2-1.3-0.9-1.3-1.11.1-1.1-1.2-1.1-0.80.8
Time to tail flick, vehicle, after self-admin0.40.50.7-0.8-0.7-0.6-0.6-0.80.6-0.6-0.7-0.8-0.60.8
Time to tail flick, test, before self-admin0.10.10.5-0.3-0.4-0.2-0.50.30.1-0.6-0.3-0.30.2-0.7
Time to tail flick, test, after self-admin0.10.10.50.30.40.70.30.2-0.30.30.30.30.2-0.0
Delta time to tail flick, vehicle, before/after SA0.10.10.40.40.50.40.70.1-0.40.40.50.30.10.1
Delta time to tail flick, test, before/after SA0.30.30.70.60.60.80.80.3-0.60.70.60.60.4-0.0
Tibia length6.618.321.5-4.5-4.3-4.6-4.6-4.34.4-4.5-4.3-4.0-4.03.3
Ambulatory time before self-admin0.81.31.91.21.31.01.21.0-1.11.41.21.20.9-0.5
Ambulatory time after self-admin0.10.10.10.20.20.20.30.3-0.30.20.20.20.2-0.3
Bone: tissue strength3.13.24.3-1.9-1.6-1.7-1.7-2.11.9-1.4-1.6-1.7-2.11.8
Total heroin consumption2.12.43.4-1.7-1.4-1.6-1.4-1.81.7-1.1-1.3-1.6-1.71.6
Bone: trabecular number1.11.83.81.31.01.01.01.7-1.50.70.91.21.9-1.8
Bone: trabecular spacing2.12.85.2-1.7-1.4-1.4-1.4-2.11.9-1.0-1.3-1.6-2.32.1
Bone: trabecular thickness0.20.20.6-0.1-0.3-0.3-0.40.4-0.2-0.7-0.3-0.10.6-0.8
Bone: trabecular tissue density0.50.70.9-0.9-0.9-0.9-0.9-0.70.9-0.9-0.9-0.9-0.80.4
Water consumed over 24 hours0.20.20.9-0.3-0.0-0.3-0.3-0.70.50.0-0.1-0.2-0.70.9
Number of responses in last shaping day0.20.20.50.40.60.50.7-0.1-0.20.70.60.4-0.10.5