Nckap5l

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Nckap5l 0.02 0.02 8.5e-03 0.01 0 0.01 0 5.8e-02 1.1e-01 5.1e-02 1.3e-01
2 Brain gene expression Nckap5l 0.05 0.06 3.3e-04 0.04 0.03 0.03 0.03 2.0e-04 1.4e-03 1.0e-03 7.2e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density7.613.115.3-3.93.3
Area under the delay curve1.21.41.9-0.91.4
BMI with tail7.124.624.7-4.95.0
BMI without tail1.85.45.7-2.32.4
Body weight7.331.833.1-5.85.5
Weight adjusted by age1.01.51.6-1.21.2
Bone surface9.817.819.7-4.44.0
Bone volume8.515.217.8-4.23.6
Breakpoint value in progressive ratio session1.31.61.9-1.11.4
Number of licking bursts1.32.02.51.3-1.6
Context. condit. distance diff. score0.10.10.2-0.40.2
Locomotion velocity, session 13.33.63.92.0-1.8
Locomotion distance, session 13.13.94.22.0-1.9
Locomotion velocity, session 20.20.30.40.6-0.4
Locomotion distance, session 22.63.64.22.1-1.7
Locomotion velocity, session 35.86.66.92.6-2.5
Locomotion distance, session 34.14.44.92.2-2.0
Stereotopy head waving bouts, day 30.10.10.1-0.30.4
Stereotopy head waving duration, day 30.00.00.0-0.10.2
Locomotion velocity, session 72.22.42.41.6-1.5
Locomotion distance, session 73.54.54.72.2-2.1
Stereotopy head waving bouts, day 70.80.81.0-1.00.8
Stereotopy head waving duration, day 71.01.21.4-1.21.0
Locomotion velocity, session 80.30.40.60.5-0.7
Locomotion distance, session 81.42.02.01.4-1.4
Degree of sensitization distance0.10.10.1-0.40.3
Degree of sensitization stereotypy0.30.40.4-0.70.5
Conditioned locomotion0.10.10.20.1-0.4
Cocaine response after cond. corrected0.00.00.0-0.00.0
Cocaine response after cond. not corrected0.30.40.40.7-0.6
Cocaine response before conditioning3.23.84.12.0-1.9
Saline control response0.00.00.10.1-0.3
Bone: connectivity density4.26.57.7-2.82.3
Bone: cortical apparent density0.10.10.20.2-0.4
Bone: cortical area7.811.913.1-3.63.3
Bone: cortical porosity0.00.00.00.1-0.2
Bone: cortical porosity0.10.10.10.3-0.3
Bone: cortical thickness2.33.94.7-2.21.7
Bone: cortical thickness0.00.00.10.3-0.0
Bone: cortical tissue density0.10.20.30.3-0.5
Condit. Reinf. active minus inactive responses0.10.10.20.2-0.4
Condit. Reinf. active-inactive response ratio0.20.20.3-0.50.3
Condit. Reinf. active responses0.70.90.90.9-1.0
Condit. Reinf. inactive responses2.93.64.22.1-1.7
Incentive salience index mean0.00.00.0-0.1-0.1
Condit. Reinf. lever presses0.30.40.5-0.70.6
Condit. Reinf. active minus inactive responses0.30.40.5-0.70.5
Condit. Reinf. active-inactive response ratio0.20.20.3-0.50.3
Condit. Reinf. active responses0.00.00.0-0.00.0
Condit. Reinf. inactive responses0.70.91.11.1-0.8
Condit. Reinf. lever presses0.00.00.00.0-0.0
Condit. Reinf. lever reinforcers received0.10.10.20.4-0.4
Conditioned reinforcement - actives0.61.01.91.4-0.4
Conditioned reinforcement - inactives4.46.58.42.9-2.2
Conditioned locomotion0.30.40.50.7-0.6
Patch foraging indifference point 0 sec5.39.910.83.0-3.3
Patch foraging indifference point AUC0.60.81.00.8-1.0
Delay disc. indifference point, 0s delay2.12.32.3-1.51.5
Delay disc. indifference point, 16s delay1.11.21.8-0.81.3
Delay disc. indifference point, 2s delay1.71.92.0-1.31.4
Delay disc. indifference point, 24s delay0.60.70.7-0.80.8
Delay disc. indifference point, 4s delay1.41.52.0-0.91.4
Delay disc. indifference point, 8s delay1.61.82.3-1.21.5
Indifference point function ln k3.96.97.6-2.72.5
Indifference point function log k3.96.97.6-2.72.5
Patch foraging total patch changes 0 sec4.99.210.32.8-3.2
Patch foraging total patch changes 12 sec5.77.47.52.7-2.7
Patch foraging total patch changes 18 sec5.48.210.22.5-3.2
Patch foraging total patch changes 24 sec3.25.56.52.1-2.6
Patch foraging total patch changes 6 sec6.810.411.03.1-3.3
Patch foraging time to switch 0 sec1.94.04.62.1-1.8
Patch foraging water rate 0 sec2.85.96.2-2.52.4
Patch foraging water rate 12 sec2.65.45.8-2.42.2
Patch foraging water rate 18 sec0.40.60.7-0.70.8
Patch foraging water rate 24 sec4.46.16.7-2.42.6
Patch foraging water rate 6 sec6.39.29.9-3.12.9
Seeking ratio, delayed vs. immediate footshock0.20.30.4-0.60.4
Distance traveled before self-admin1.92.52.91.7-1.5
Distance traveled after self-admin1.21.51.91.1-1.4
Extensor digitorum longus weight5.120.220.5-4.54.5
Bone: elastic displacement5.86.77.12.7-2.5
Bone: elastic work0.00.00.00.10.0
Bone: endosteal estimation7.817.117.6-4.14.2
Bone: endosteal perimeter7.516.016.6-4.13.9
Epididymis fat weight0.41.41.5-1.21.2
Delta time in closed arm before/after self-admin0.10.10.1-0.3-0.2
Delta time in open arm before/after self-admin1.41.41.61.1-1.3
Diff in mean of infusions in LGA sessions0.91.11.5-0.81.2
Delay discount exponential model param1.21.42.00.9-1.4
Extinction: sum of active levers before priming2.52.73.0-1.61.7
Active lever presses in extinction session 60.30.30.3-0.50.5
Bone: final force12.520.021.2-4.64.3
Bone: final moment14.022.524.0-4.94.6
Food consumed during 24 hour testing period1.11.52.1-1.40.9
Glucose0.20.30.40.6-0.5
Heart weight0.10.20.3-0.40.5
Delay discount hyperbolic model param1.21.41.90.9-1.4
Intermittent access intake day 1-15 change0.10.20.4-0.10.6
Intermittent access intake escalation0.30.60.9-0.50.9
Intermittent access intake escalation 20.00.00.10.00.3
Intermitt. access day 1 inactive lever presses0.10.20.30.4-0.6
Intermitt. access day 15 inactive lever presses0.00.10.10.3-0.2
Intermitt. access escalation Index0.00.10.1-0.30.0
Intermittent access day 1 total infusions1.42.22.31.5-1.5
Intermittent access day 15 total infusions0.50.81.21.1-0.6
Intermittent access terminal intake (last 3 days)0.91.11.51.2-0.9
Intermittent access total infusions1.72.02.51.6-1.2
Intermittent access day 1 locomotion0.71.01.01.0-1.0
Intermittent access day 15 total locomotion0.40.70.70.8-0.8
Intermittent access total locomotion2.32.83.11.7-1.6
Intermittent access standard deviation0.10.20.30.60.2
Left kidney weight1.46.67.3-2.42.7
Right kidney weight4.821.722.7-4.64.8
Cocaine induced anxiety2.33.33.3-1.81.8
Post-drug Anxiety3.94.24.9-1.92.2
Baseline Anxiety0.20.30.3-0.50.5
Tail length0.00.00.0-0.0-0.2
Length with tail1.67.08.0-2.82.4
Length without tail6.019.321.4-4.64.1
Times rat made contact with spout0.10.10.20.2-0.5
Lifetime Intake2.73.23.92.0-1.6
Liver weight, left10.617.518.8-4.34.0
Liver weight, right3.46.06.3-2.52.4
Locomotor activity1.93.03.61.9-1.5
Locomotor testing distance3.86.97.62.8-2.5
Locomotor testing rearing2.44.85.52.3-2.0
Locomotion in novel chamber3.74.75.3-2.32.0
Locomotion in novel chamber post-restriction0.10.10.2-0.40.3
Fecal boli incidents, locomotor time 11.01.42.41.5-0.7
Change in fecal boli incidents, locomotor task0.30.20.5-0.7-0.0
Time >=10cm from walls, locomotor time 10.20.20.40.7-0.1
Bouts of movement, locomotor time 10.00.00.0-0.00.0
Total resting periods, locomotor time 10.30.40.40.6-0.6
Rest time, locomotor task time 10.80.91.30.8-1.1
Distance moved, locomotor task time 10.00.00.1-0.1-0.2
Vertical activity count, locomotor time 10.41.11.1-1.01.1
Time >=10cm from walls, locomotor time 20.30.51.01.0-0.2
Bouts of movement, locomotor time 22.54.05.5-2.31.6
Total resting periods, locomotor time 22.44.36.2-2.51.5
Rest time, locomotor task time 20.30.40.60.3-0.8
Distance moved, locomotor task time 20.00.00.10.30.1
Vertical activity count, locomotor time 20.10.10.2-0.20.4
Light reinforcement 11.02.42.61.5-1.6
Light reinforcement 20.00.10.1-0.1-0.3
Bone: marrow area7.416.216.5-4.04.1
Bone: maximum diameter2.54.64.7-2.12.2
Bone: maximum force16.429.230.4-5.55.3
Bone: maximum moment18.332.133.7-5.85.5
Mean time between licks in bursts0.00.10.10.3-0.3
Mean num. licks in bursts0.40.70.7-0.80.9
Cd content in liver0.50.50.70.8-0.7
Co content in liver0.30.30.50.7-0.4
Cu content in liver0.10.10.1-0.20.3
Fe content in liver1.82.22.41.6-1.4
K content in liver0.00.00.00.2-0.1
Mg content in liver0.20.20.30.3-0.5
Mn content in liver0.00.00.00.0-0.0
Na content in liver0.00.00.1-0.30.1
Rb content in liver1.51.71.91.2-1.4
Se content in liver3.44.14.22.1-2.0
Sr content in liver0.60.50.8-0.90.5
Zn content in liver1.01.21.31.0-1.1
Bone: minimum diameter9.216.818.2-4.33.9
Time in familiar zone, hab. session 10.00.00.1-0.1-0.2
Time in novel zone, hab. session 10.00.00.0-0.10.1
Total zone transitions, hab. session 10.10.10.10.3-0.3
Total locomotion distance, hab. session 10.10.20.20.4-0.5
Locomotion velocity, hab. session 10.10.10.10.3-0.3
Time in familiar zone, hab. session 21.51.51.8-1.31.1
Time in novel zone, hab. session 21.61.61.81.3-1.2
Total zone transitions, hab. session 20.20.30.30.5-0.5
Total locomotion distance, hab. session 20.30.30.40.5-0.6
Locomotion velocity, hab. session 20.10.20.30.3-0.5
Novel to familiar place preference ratio1.31.42.0-1.40.9
Novelty place preference0.70.81.2-1.10.6
Time in novel zone, NPP test0.50.50.9-0.90.4
Total zone transitions, NPP test2.63.73.71.9-1.9
Total locomotion distance, NPP test3.54.74.82.2-2.2
Locomotion velocity, NPP test2.23.13.21.7-1.8
Intraocular pressure6.39.19.53.0-3.1
Delta distance traveled before/after self-admin0.10.10.1-0.3-0.2
Delta ambulatory time before/after self-admin0.00.10.1-0.0-0.3
Parametrial fat weight0.71.62.01.4-1.1
Pavlov. Cond. lever latency0.00.10.10.1-0.3
Pavlov. Cond. magazine entry latency0.70.91.3-0.81.1
Pavlov. Cond. change in total contacts1.11.11.5-0.91.2
Pavlov. Cond. index score0.60.81.1-0.71.0
Pavlov. Cond. latency score0.50.60.8-0.60.9
Pavlov. Cond. lever contacts0.00.00.10.10.3
Pavlov. Cond. magazine entry number0.40.40.70.4-0.9
Pavlov. Cond. intertrial magazine entries3.54.24.42.1-2.0
Pavlov. Cond. lever-magazine prob. diff.1.01.21.6-0.91.3
Pavlov. Cond. response bias0.20.20.3-0.20.6
Pavlov. Cond. lever latency0.81.11.2-1.11.1
Pavlov. Cond. magazine entry latency0.00.00.00.10.0
Pavlov. Cond. change in total contacts0.50.71.0-1.00.7
Pavlov. Cond. index score0.10.10.10.3-0.3
Pavlov. Cond. latency score0.10.20.20.4-0.4
Pavlov. Cond. lever contacts0.60.80.80.9-0.9
Pavlov. Cond. magazine entry number0.10.20.20.4-0.4
Pavlov. Cond. intertrial magazine entries3.14.75.12.3-2.1
Pavlov. Cond. lever-magazine prob. diff.0.00.00.00.1-0.2
Pavlov. Cond. response bias0.20.30.30.5-0.5
Time in closed arm before self-admin1.82.32.7-1.41.6
Time in closed arm after self-admin0.40.50.5-0.70.7
Time in open arm before self-admin0.30.30.40.5-0.6
Time in open arm after self-admin0.30.30.40.4-0.7
Bone: periosteal estimation11.023.324.1-4.94.7
Bone: periosteal perimeter10.317.818.7-4.34.1
Bone: post-yield work9.013.213.5-3.63.7
Progressive ratio test 1 active lever presses7.79.510.33.2-3.0
Progressive ratio test 1 breakpoint7.49.19.73.1-2.9
Progressive ratio test 1 inactive lever presses0.71.11.51.2-0.8
Progressive ratio test 2 active lever presses1.92.23.21.8-1.1
Progressive ratio test 2 breakpoint1.72.02.91.7-1.0
Progressive ratio test 2 inactive lever presses0.61.01.51.2-0.6
Incentive Sensitization - Responses0.40.61.0-0.51.0
Incentive Sensitization - Breakpoint0.40.50.8-0.40.9
Sum of active levers in priming session hrs 5-60.00.00.0-0.0-0.2
Progressive ratio1.21.82.01.4-1.3
Food seeking constrained by brief footshock2.32.83.41.8-1.5
Seeking ratio, punishment vs. effort0.10.10.1-0.30.3
Retroperitoneal fat weight0.72.93.82.0-1.4
Reaction time number correct1.42.63.4-1.81.4
Reaction time mean minus median3.99.810.63.3-3.0
Reaction time mean minus median AUC2.66.67.32.7-2.4
Reaction time num false alarms1.72.32.51.5-1.6
Reaction time num false alarms AUC1.82.92.91.7-1.7
Reaction time trials correct on left1.42.63.4-1.81.4
Reaction time trials on left1.12.12.7-1.71.2
Reaction time mean0.81.31.31.1-1.2
Reaction time mean AUC0.50.80.80.9-0.9
Median of all reaction times0.00.00.10.2-0.2
Reaction time omissions8.812.814.43.8-3.4
Reaction time false alarm rate2.63.64.02.0-1.8
Reaction time premature initiation rate4.46.18.52.9-1.9
Reaction time premature initiations1.32.23.41.8-1.0
Std. dev. reaction times4.99.09.63.1-2.9
Reaction time trials completed1.12.12.7-1.71.2
Reaction time trials AUC1.83.34.3-2.11.5
Run reversals in cocaine runway, females0.60.60.7-0.90.6
Run reversals in cocaine runway, males1.01.01.30.8-1.2
Latency to leave start box in cocaine runway0.10.10.10.20.3
Latency to leave start box in cocaine runway, F0.91.11.71.3-0.6
Latency to leave start box in cocaine runway, M2.11.92.1-1.41.3
Std. dev. time between licks in bursts1.41.92.11.3-1.4
Total sessions with >9 infusions3.03.74.12.0-1.8
Short access day 1 total inactive lever presses1.82.42.71.6-1.5
Short access day 10 total inactive lever presses0.10.20.2-0.4-0.4
Short access day 1 total infusions1.62.12.11.4-1.4
Short access day 10 total infusions2.22.83.11.6-1.8
Short access total infusions4.15.35.62.4-2.2
Short access day 1 locomotion0.60.70.90.7-1.0
Short access day 10 total locomotion0.30.50.50.7-0.7
Short access total locomotion1.41.72.01.1-1.4
One hour access (0.3 mA shock)0.20.20.3-0.00.6
Compulsive drug intake0.30.30.3-0.60.5
One hour access (shock baseline)0.10.10.3-0.10.5
Social response proportion0.50.50.80.9-0.6
Social responses7.810.012.13.5-2.8
Social time0.20.30.6-0.20.8
Soleus weight1.23.63.7-1.91.9
Bone: stiffness21.234.436.5-6.05.7
Tibialis anterior weight2.48.29.0-2.73.0
Time to tail flick, vehicle, before self-admin1.31.41.41.2-1.2
Time to tail flick, vehicle, after self-admin0.40.50.7-0.50.9
Time to tail flick, test, before self-admin0.20.20.20.4-0.4
Time to tail flick, test, after self-admin1.31.31.5-1.21.1
Delta time to tail flick, vehicle, before/after SA0.80.70.9-0.80.9
Delta time to tail flick, test, before/after SA0.50.50.7-0.80.5
Tibia length4.913.415.2-3.93.4
Ambulatory time before self-admin2.43.74.22.0-1.8
Ambulatory time after self-admin2.12.53.01.4-1.7
Bone: tissue strength1.41.51.5-1.21.2
Total heroin consumption0.70.80.9-0.90.9
Bone: trabecular number4.47.38.9-3.02.4
Bone: trabecular spacing1.52.02.41.5-1.3
Bone: trabecular thickness0.20.20.4-0.60.3
Bone: trabecular tissue density0.40.50.8-0.90.5
Water consumed over 24 hours0.00.10.1-0.1-0.3
Number of responses in last shaping day0.10.10.1-0.1-0.4