Hub : Genes

Nck2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Nck2 0.83 0.06 0.0e+00 0.38 0.39 0.38 0.37 3.1e-44 1.3e-45 4.1e-44 2.1e-43
2 Brain mRNA stability Nck2 0.1 0.06 4.7e-10 0.1 0.1 0.1 0.1 6.6e-10 1.9e-09 6.0e-10 5.3e-10
3 Liver mRNA stability Nck2 0.31 0.16 5.9e-13 0.08 0.08 0.08 0.08 1.5e-09 2.2e-09 6.6e-09 1.4e-09
4 Liver alternative TSS NM_001108216.1 0.07 0.04 6.0e-04 0.03 0.02 0.02 0.03 7.4e-04 2.2e-03 1.1e-03 8.5e-04
5 Liver alternative TSS XM_006244825.5 0.08 0.05 2.1e-04 0.03 0.02 0.02 0.02 4.1e-04 2.5e-03 2.8e-03 9.4e-04
6 IL mRNA stability Nck2 0.23 0.14 1.3e-03 0.11 0.08 0.09 0.03 1.6e-03 5.9e-03 4.5e-03 5.3e-02
7 pVTA gene expression Nck2 0.12 0.07 2.4e-06 0.06 0.06 0.04 0.05 5.6e-06 1.1e-05 1.5e-04 3.8e-05
8 Liver alternative TSS XM_063267164.1 0.07 0.05 3.8e-04 0.02 0.02 0.02 0.02 1.2e-03 3.1e-03 3.7e-03 1.8e-03
9 Brain gene expression Nck2 0.21 0.14 2.7e-06 0.06 0.06 0.06 0.06 1.8e-06 3.0e-06 7.3e-06 4.0e-06
10 BLA mRNA stability Nck2 0.12 0.1 2.7e-04 0.09 0.07 0.06 0.04 2.7e-05 1.4e-04 4.3e-04 3.8e-03
11 Adipose gene expression Nck2 0.05 0.03 5.4e-06 0.03 0.03 0.01 0.03 3.2e-04 2.8e-04 6.8e-03 4.2e-04
12 IL intron excision ratio chr9_53295118_53316117 0.17 0.12 6.5e-03 -0.01 0.03 0.01 -0.01 7.7e-01 6.9e-02 2.2e-01 6.1e-01
13 PL mRNA stability Nck2 0.07 0.04 5.6e-09 0.06 0.07 0.06 0.04 1.4e-07 9.8e-08 3.5e-07 1.0e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density4.27.310.1-1.9-3.0-1.9-1.8-1.8-2.93.12.13.2-3.23.13.1-3.1
Area under the delay curve0.40.51.1-0.40.4-0.6-0.7-0.70.5-0.70.8-0.60.7-0.7-1.01.0
BMI with tail1.03.65.32.22.11.51.81.82.2-2.3-0.8-2.32.2-1.5-1.51.9
BMI without tail0.10.41.6-0.60.3-0.4-0.8-0.80.5-0.51.3-0.50.4-0.2-0.40.6
Body weight0.10.20.60.10.5-0.1-0.2-0.20.7-0.70.8-0.60.60.1-0.00.4
Weight adjusted by age1.01.64.71.61.12.21.61.61.0-0.5-2.1-0.30.4-0.9-0.60.4
Bone surface0.30.60.9-0.5-0.8-0.6-0.4-0.4-0.80.80.70.8-0.80.90.9-0.8
Bone volume1.93.34.9-1.3-2.1-1.3-1.2-1.2-2.02.01.52.1-2.12.22.2-2.1
Breakpoint value in progressive ratio session1.41.73.4-1.8-1.1-1.8-1.7-1.7-1.00.81.60.9-0.81.00.9-0.7
Number of licking bursts0.30.51.9-1.4-0.3-0.8-1.3-1.3-0.30.40.60.4-0.40.10.1-0.1
Context. condit. distance diff. score0.81.02.0-0.1-1.2-0.3-0.2-0.2-1.21.20.71.0-1.01.41.4-1.3
Locomotion velocity, session 10.00.00.1-0.30.0-0.3-0.4-0.40.0-0.10.2-0.10.10.0-0.00.1
Locomotion distance, session 11.41.72.61.61.31.61.51.51.2-1.1-1.5-1.31.2-1.1-1.00.9
Locomotion velocity, session 23.74.35.51.92.41.81.91.92.3-2.2-2.0-2.12.1-2.3-2.22.1
Locomotion distance, session 23.34.66.12.12.41.81.91.92.5-2.3-1.5-2.42.4-2.2-2.22.2
Locomotion velocity, session 30.10.10.2-0.1-0.40.10.10.1-0.30.4-0.10.2-0.30.30.4-0.4
Locomotion distance, session 30.20.20.4-0.4-0.6-0.5-0.3-0.3-0.50.40.30.3-0.40.40.5-0.4
Stereotopy head waving bouts, day 30.30.30.6-0.3-0.8-0.2-0.4-0.4-0.70.60.70.6-0.50.60.5-0.5
Stereotopy head waving duration, day 30.20.20.4-0.5-0.6-0.2-0.5-0.5-0.50.60.60.6-0.50.40.3-0.4
Locomotion velocity, session 71.61.83.91.81.01.91.91.90.8-0.5-2.0-0.60.5-1.1-0.80.5
Locomotion distance, session 70.81.01.51.21.01.01.21.21.0-0.9-1.0-0.80.8-1.1-1.00.9
Stereotopy head waving bouts, day 70.20.20.5-0.1-0.6-0.2-0.1-0.1-0.70.50.30.4-0.40.50.5-0.5
Stereotopy head waving duration, day 70.20.20.60.2-0.60.20.20.2-0.80.6-0.20.4-0.50.50.7-0.7
Locomotion velocity, session 80.40.41.31.00.21.01.01.00.00.0-1.2-0.10.10.10.4-0.4
Locomotion distance, session 80.91.43.61.90.91.41.71.70.9-0.8-1.2-1.11.0-0.5-0.30.4
Degree of sensitization distance1.31.32.21.11.30.90.90.91.3-1.2-0.7-1.01.2-1.4-1.51.4
Degree of sensitization stereotypy0.10.10.20.3-0.30.00.20.2-0.40.2-0.10.1-0.10.30.4-0.3
Conditioned locomotion0.40.41.4-0.8-0.4-0.9-0.9-0.9-0.0-0.21.2-0.20.20.70.5-0.1
Cocaine response after cond. corrected0.50.71.3-0.30.6-0.8-0.5-0.51.0-0.90.6-1.01.0-0.8-1.01.2
Cocaine response after cond. not corrected0.40.51.0-0.10.7-0.5-0.2-0.20.9-0.90.3-0.90.9-0.7-0.81.0
Cocaine response before conditioning0.30.41.30.80.21.00.80.8-0.00.1-1.10.2-0.10.00.2-0.3
Saline control response0.71.01.91.40.71.31.41.40.5-0.7-1.3-0.80.8-0.6-0.40.4
Bone: connectivity density0.91.41.8-1.0-1.2-0.9-0.9-0.9-1.21.31.11.3-1.31.31.3-1.2
Bone: cortical apparent density3.95.39.22.82.12.93.03.01.7-1.7-3.0-1.71.7-2.0-1.71.4
Bone: cortical area0.10.20.60.80.40.50.70.70.2-0.4-0.4-0.30.30.00.10.1
Bone: cortical porosity1.61.72.4-1.3-1.3-1.1-1.1-1.1-1.51.50.81.5-1.51.31.3-1.4
Bone: cortical porosity1.82.02.8-1.1-1.5-1.0-1.0-1.0-1.71.70.81.7-1.71.51.5-1.6
Bone: cortical thickness0.10.20.50.70.40.40.60.60.2-0.4-0.5-0.40.40.10.10.0
Bone: cortical thickness0.10.10.30.50.20.30.40.40.2-0.4-0.2-0.40.4-0.0-0.00.2
Bone: cortical tissue density3.64.98.92.72.02.93.03.01.6-1.5-3.0-1.61.6-1.8-1.51.3
Condit. Reinf. active minus inactive responses0.20.20.3-0.10.4-0.6-0.5-0.50.5-0.30.4-0.40.3-0.4-0.50.6
Condit. Reinf. active-inactive response ratio0.20.20.8-0.3-0.1-0.9-0.7-0.7-0.1-0.00.6-0.20.1-0.0-0.20.3
Condit. Reinf. active responses0.10.20.50.30.6-0.1-0.1-0.10.7-0.30.1-0.50.4-0.4-0.50.5
Condit. Reinf. inactive responses0.70.81.60.91.10.80.80.81.2-0.9-0.7-1.00.9-0.9-0.90.9
Incentive salience index mean0.00.00.10.00.1-0.3-0.4-0.40.00.00.2-0.10.00.1-0.00.1
Condit. Reinf. lever presses0.20.20.60.2-0.40.30.00.0-0.70.5-0.10.4-0.40.70.8-0.7
Condit. Reinf. active minus inactive responses0.50.71.6-1.2-0.6-1.2-1.2-1.2-0.50.61.10.6-0.60.40.3-0.3
Condit. Reinf. active-inactive response ratio1.72.03.0-1.7-1.5-1.7-1.7-1.7-1.31.11.61.1-1.11.31.1-1.0
Condit. Reinf. active responses0.20.20.4-0.40.5-0.5-0.5-0.50.6-0.30.5-0.30.3-0.5-0.60.6
Condit. Reinf. inactive responses1.41.82.91.41.71.41.41.41.5-1.1-1.3-1.01.0-1.4-1.41.2
Condit. Reinf. lever presses0.30.50.9-0.9-0.6-0.9-0.8-0.8-0.60.70.70.7-0.70.40.3-0.4
Condit. Reinf. lever reinforcers received0.20.30.7-0.30.6-0.4-0.4-0.40.8-0.50.3-0.50.5-0.7-0.80.8
Conditioned reinforcement - actives0.10.10.5-0.2-0.1-0.70.10.10.1-0.40.5-0.40.4-0.2-0.30.4
Conditioned reinforcement - inactives0.20.31.31.10.10.11.21.20.0-0.3-0.4-0.30.20.10.1-0.1
Conditioned locomotion1.31.64.42.10.71.02.12.10.8-1.2-0.9-1.11.2-0.7-0.60.7
Patch foraging indifference point 0 sec0.50.92.41.20.51.41.51.50.3-0.4-1.5-0.30.4-0.5-0.30.1
Patch foraging indifference point AUC0.40.61.30.70.70.10.50.50.8-1.1-0.2-1.11.1-0.8-0.91.0
Delay disc. indifference point, 0s delay0.80.92.11.30.81.31.11.10.3-0.6-1.4-0.60.6-0.9-0.70.5
Delay disc. indifference point, 16s delay1.11.23.6-1.4-0.8-1.9-1.6-1.6-0.30.41.80.4-0.30.50.2-0.1
Delay disc. indifference point, 2s delay0.30.30.80.50.3-0.40.20.20.3-0.70.5-0.60.6-0.6-0.80.9
Delay disc. indifference point, 24s delay0.10.10.3-0.5-0.3-0.6-0.6-0.60.10.30.40.2-0.20.0-0.0-0.1
Delay disc. indifference point, 4s delay0.60.61.11.00.70.80.70.70.5-0.9-0.4-0.80.8-0.8-0.80.8
Delay disc. indifference point, 8s delay0.30.30.9-0.80.0-0.6-0.9-0.90.0-0.20.8-0.10.2-0.4-0.60.6
Indifference point function ln k0.50.91.9-0.01.21.10.30.31.3-0.6-1.3-0.50.5-1.4-1.31.0
Indifference point function log k0.50.91.9-0.01.21.10.30.31.3-0.6-1.3-0.50.5-1.4-1.31.0
Patch foraging total patch changes 0 sec0.50.92.41.30.71.21.51.50.6-0.7-1.2-0.60.7-0.6-0.50.4
Patch foraging total patch changes 12 sec0.30.30.80.8-0.60.30.90.9-0.8-0.1-0.4-0.00.10.50.6-0.5
Patch foraging total patch changes 18 sec0.71.01.70.71.10.60.80.81.1-1.3-0.7-1.31.3-1.0-1.11.1
Patch foraging total patch changes 24 sec0.50.92.81.70.21.01.71.70.1-0.6-0.9-0.70.7-0.1-0.10.1
Patch foraging total patch changes 6 sec0.30.41.61.20.10.51.31.30.0-0.0-0.6-0.10.1-0.1-0.0-0.1
Patch foraging time to switch 0 sec0.51.11.8-0.8-1.3-0.7-0.5-0.5-1.31.20.51.1-1.21.11.2-1.3
Patch foraging water rate 0 sec0.40.71.5-0.10.8-0.1-0.3-0.31.2-1.20.4-1.11.1-0.8-1.01.2
Patch foraging water rate 12 sec0.10.20.60.00.70.2-0.0-0.00.7-0.4-0.2-0.40.4-0.7-0.80.6
Patch foraging water rate 18 sec0.10.20.5-0.7-0.20.3-0.6-0.6-0.40.7-0.10.7-0.7-0.00.0-0.3
Patch foraging water rate 24 sec0.10.10.40.20.40.60.10.10.40.2-0.20.1-0.2-0.5-0.50.3
Patch foraging water rate 6 sec0.20.41.0-0.40.80.4-0.5-0.50.6-0.1-0.4-0.20.1-1.0-1.00.8
Seeking ratio, delayed vs. immediate footshock0.50.71.5-0.6-0.9-0.2-0.7-0.7-0.80.60.70.7-0.71.21.2-0.9
Distance traveled before self-admin1.01.42.3-0.7-1.2-0.6-0.8-0.8-1.01.41.11.4-1.51.51.5-1.4
Distance traveled after self-admin3.84.77.8-1.1-2.6-0.7-1.0-1.0-2.72.51.02.6-2.52.72.8-2.7
Extensor digitorum longus weight7.429.034.95.35.95.65.35.35.5-5.2-5.5-5.15.1-5.7-5.45.1
Bone: elastic displacement1.71.93.7-1.9-1.1-1.9-1.8-1.8-0.81.21.61.3-1.30.90.8-0.8
Bone: elastic work0.91.21.7-1.1-0.9-1.3-1.1-1.1-0.70.91.31.1-1.11.21.1-0.9
Bone: endosteal estimation0.00.00.4-0.1-0.3-0.3-0.1-0.1-0.1-0.00.60.1-0.10.20.1-0.0
Bone: endosteal perimeter0.00.00.2-0.2-0.2-0.4-0.2-0.2-0.10.00.50.1-0.10.20.10.0
Epididymis fat weight0.20.60.90.60.90.30.80.80.9-1.0-0.2-0.70.7-0.8-0.91.0
Delta time in closed arm before/after self-admin0.30.30.8-0.9-0.3-0.7-0.7-0.7-0.30.60.40.7-0.60.10.1-0.3
Delta time in open arm before/after self-admin0.10.10.20.4-0.2-0.1-0.1-0.1-0.10.40.20.4-0.50.30.3-0.3
Diff in mean of infusions in LGA sessions0.60.71.9-1.0-0.5-1.1-1.4-1.4-0.30.41.10.4-0.50.80.7-0.5
Delay discount exponential model param0.40.51.10.4-0.40.60.70.7-0.50.7-0.90.6-0.70.71.0-1.0
Extinction: sum of active levers before priming2.22.46.5-1.0-1.7-2.3-1.3-1.3-1.30.92.50.9-0.72.11.8-1.2
Active lever presses in extinction session 60.50.51.00.40.8-0.6-0.0-0.00.9-1.00.8-0.91.0-0.4-0.71.0
Bone: final force0.20.41.61.20.30.71.11.10.2-0.2-0.4-0.20.20.30.4-0.2
Bone: final moment0.20.31.41.20.30.61.01.00.3-0.2-0.4-0.20.20.20.2-0.1
Food consumed during 24 hour testing period0.40.61.20.60.70.40.40.40.9-1.0-0.1-1.01.1-0.8-0.81.0
Glucose0.40.61.4-1.2-0.7-1.2-1.0-1.0-0.50.41.10.3-0.30.50.3-0.2
Heart weight0.10.10.3-0.50.40.2-0.3-0.30.4-0.3-0.1-0.30.1-0.5-0.60.5
Delay discount hyperbolic model param0.40.51.20.2-0.50.40.50.5-0.50.7-0.80.7-0.70.81.0-1.1
Intermittent access intake day 1-15 change0.30.61.2-0.4-1.0-0.1-0.2-0.2-1.11.00.01.0-1.00.80.8-0.9
Intermittent access intake escalation0.30.71.4-0.3-1.1-0.0-0.1-0.1-1.21.1-0.11.1-1.10.80.9-1.0
Intermittent access intake escalation 21.31.52.6-1.2-1.3-0.5-1.1-1.1-1.31.60.61.6-1.51.11.1-1.3
Intermitt. access day 1 inactive lever presses0.10.51.40.4-1.0-1.20.30.3-0.70.20.70.3-0.20.90.9-0.6
Intermitt. access day 15 inactive lever presses0.20.41.51.1-0.10.51.21.2-0.2-0.1-1.0-0.10.0-0.10.1-0.2
Intermitt. access escalation Index0.10.20.50.40.60.70.20.20.40.4-0.50.4-0.4-0.3-0.1-0.1
Intermittent access day 1 total infusions0.71.15.3-0.7-0.2-2.3-1.1-1.10.3-0.72.2-0.70.60.3-0.10.5
Intermittent access day 15 total infusions0.40.51.5-0.6-0.9-1.2-0.6-0.6-0.80.61.00.6-0.60.70.5-0.5
Intermittent access terminal intake (last 3 days)0.20.31.7-0.3-0.3-1.3-0.5-0.5-0.10.01.20.1-0.00.40.2-0.1
Intermittent access total infusions0.50.62.9-0.8-0.7-1.7-0.9-0.9-0.40.01.40.1-0.10.40.2-0.0
Intermittent access day 1 locomotion0.30.40.90.50.6-0.70.10.10.8-0.90.6-0.90.9-0.3-0.50.7
Intermittent access day 15 total locomotion0.20.30.40.60.50.30.50.50.5-0.6-0.6-0.60.6-0.7-0.60.6
Intermittent access total locomotion0.30.40.80.50.5-0.20.30.30.6-0.9-0.2-0.90.9-0.6-0.70.7
Intermittent access standard deviation0.40.92.0-0.8-1.4-1.1-0.5-0.5-1.10.71.20.7-0.61.11.0-0.8
Left kidney weight0.10.51.0-1.0-0.7-0.0-0.7-0.7-0.80.60.30.6-0.60.90.9-0.9
Right kidney weight0.10.51.61.00.31.31.01.0-0.1-0.3-1.0-0.30.30.20.4-0.3
Cocaine induced anxiety0.50.71.81.20.61.11.31.30.4-0.2-1.4-0.20.2-0.6-0.40.1
Post-drug Anxiety1.41.53.61.90.91.41.81.80.7-1.1-1.2-1.11.0-0.8-0.70.7
Baseline Anxiety0.40.51.50.40.3-0.30.20.20.5-1.20.8-1.21.1-0.4-0.60.9
Tail length1.14.39.2-3.0-1.8-2.4-2.9-2.9-1.51.32.71.4-1.41.61.3-1.1
Length with tail0.62.74.2-2.0-1.6-1.9-2.0-2.0-1.21.22.11.3-1.31.71.5-1.3
Length without tail0.00.10.40.70.20.10.60.60.1-0.4-0.1-0.30.30.10.10.0
Times rat made contact with spout1.31.53.6-1.8-0.8-1.6-1.9-1.9-0.50.61.90.5-0.50.70.4-0.2
Lifetime Intake0.30.31.9-0.3-0.4-1.4-0.3-0.3-0.2-0.41.1-0.40.40.2-0.10.3
Liver weight, left0.40.72.4-1.1-0.1-1.5-1.3-1.30.1-0.11.50.1-0.00.3-0.00.2
Liver weight, right0.50.83.5-0.9-0.7-1.2-1.2-1.2-0.40.31.90.4-0.30.90.7-0.4
Locomotor activity0.20.40.6-0.6-0.4-0.6-0.6-0.6-0.20.80.70.8-0.80.60.5-0.5
Locomotor testing distance1.12.03.0-1.1-1.4-1.1-1.2-1.2-1.31.71.11.7-1.71.51.5-1.6
Locomotor testing rearing1.32.74.5-1.0-1.9-0.8-1.0-1.0-2.12.10.72.0-2.11.71.8-1.9
Locomotion in novel chamber5.87.410.62.53.12.42.22.23.3-3.1-1.9-3.03.0-2.7-2.72.8
Locomotion in novel chamber post-restriction1.83.04.31.91.91.51.71.71.9-2.1-0.9-2.02.0-1.5-1.51.7
Fecal boli incidents, locomotor time 10.91.32.20.51.20.40.50.51.4-1.4-0.4-1.41.4-1.3-1.41.5
Change in fecal boli incidents, locomotor task0.10.10.4-0.0-0.4-0.6-0.1-0.1-0.50.20.30.2-0.20.50.5-0.4
Time >=10cm from walls, locomotor time 12.52.64.50.91.81.81.31.31.7-1.3-1.9-1.31.4-2.1-2.01.6
Bouts of movement, locomotor time 16.06.811.81.33.10.61.11.13.3-3.3-0.8-3.23.2-3.1-3.33.4
Total resting periods, locomotor time 16.67.411.91.63.20.91.41.43.4-3.4-1.1-3.33.3-3.2-3.33.4
Rest time, locomotor task time 10.70.82.6-0.70.2-1.3-1.0-1.00.3-0.91.6-0.90.9-0.3-0.71.0
Distance moved, locomotor task time 10.10.10.4-0.50.00.4-0.4-0.40.10.5-0.60.5-0.5-0.1-0.0-0.3
Vertical activity count, locomotor time 10.41.01.9-0.7-0.90.4-0.5-0.5-1.21.4-0.61.3-1.40.91.1-1.4
Time >=10cm from walls, locomotor time 20.10.10.4-0.5-0.0-0.4-0.6-0.6-0.00.10.20.00.1-0.0-0.00.0
Bouts of movement, locomotor time 21.82.84.81.51.91.11.31.32.2-2.0-0.8-2.01.9-1.6-1.71.8
Total resting periods, locomotor time 21.32.43.81.51.70.91.31.32.0-1.8-0.7-1.91.8-1.4-1.51.6
Rest time, locomotor task time 20.20.20.5-0.7-0.6-0.7-0.5-0.5-0.70.30.60.3-0.30.30.2-0.2
Distance moved, locomotor task time 20.50.61.30.21.10.8-0.0-0.01.0-0.7-0.8-0.60.6-1.1-1.00.9
Vertical activity count, locomotor time 20.40.51.30.90.91.10.60.60.6-0.6-1.0-0.60.6-0.5-0.40.4
Light reinforcement 12.97.112.23.52.42.53.43.42.0-2.8-2.2-2.62.7-2.3-2.22.3
Light reinforcement 21.21.83.51.91.31.21.71.71.0-1.5-0.5-1.41.5-1.0-1.11.2
Bone: marrow area0.00.00.3-0.0-0.2-0.2-0.0-0.00.0-0.10.50.0-0.00.10.00.1
Bone: maximum diameter0.10.20.4-0.2-0.4-0.3-0.1-0.1-0.40.20.50.3-0.30.60.6-0.4
Bone: maximum force0.30.51.81.30.50.71.11.10.4-0.4-0.5-0.40.40.10.20.0
Bone: maximum moment0.30.51.71.30.60.71.11.10.6-0.5-0.5-0.50.5-0.1-0.00.2
Mean time between licks in bursts0.81.92.21.31.41.51.51.51.2-1.3-1.5-1.31.3-1.4-1.31.2
Mean num. licks in bursts0.10.20.40.60.30.20.50.50.4-0.50.2-0.50.5-0.2-0.30.4
Cd content in liver3.64.07.2-2.2-1.9-2.6-2.5-2.5-1.61.62.71.6-1.61.81.6-1.4
Co content in liver1.21.42.7-1.4-1.0-1.6-1.5-1.5-0.70.91.60.9-0.91.00.8-0.7
Cu content in liver0.20.20.3-0.4-0.5-0.4-0.4-0.4-0.50.50.50.5-0.40.50.4-0.4
Fe content in liver2.83.44.6-1.6-2.1-1.6-1.6-1.6-2.11.81.71.8-1.82.12.1-2.0
K content in liver1.71.72.51.41.31.61.61.61.1-1.0-1.5-1.01.1-1.2-1.11.0
Mg content in liver0.30.30.70.60.30.80.80.80.2-0.1-0.8-0.00.1-0.4-0.30.2
Mn content in liver0.80.82.01.30.61.41.31.30.5-0.4-1.4-0.40.4-0.5-0.40.3
Na content in liver1.01.12.2-0.3-1.1-0.0-0.1-0.1-1.31.50.11.4-1.41.21.3-1.5
Rb content in liver5.66.57.82.82.62.42.42.42.5-2.7-2.3-2.82.8-2.4-2.42.4
Se content in liver0.50.61.30.50.80.40.30.30.9-1.1-0.2-1.11.1-0.6-0.70.9
Sr content in liver0.10.10.3-0.6-0.0-0.5-0.5-0.50.20.10.50.1-0.1-0.2-0.30.3
Zn content in liver0.10.20.3-0.4-0.5-0.3-0.4-0.4-0.40.50.40.5-0.40.30.3-0.3
Bone: minimum diameter0.50.91.91.41.01.01.21.20.9-1.0-0.6-0.90.9-0.6-0.60.7
Time in familiar zone, hab. session 10.80.82.7-1.0-0.4-1.6-1.2-1.20.0-0.01.60.1-0.10.50.20.1
Time in novel zone, hab. session 10.70.71.1-0.9-0.9-0.5-0.8-0.8-1.01.10.40.9-1.00.70.7-0.8
Total zone transitions, hab. session 10.50.72.01.1-0.01.41.31.3-0.30.3-1.40.3-0.30.00.3-0.6
Total locomotion distance, hab. session 11.01.42.21.31.11.51.31.31.2-1.0-1.2-1.01.1-1.1-1.00.9
Locomotion velocity, hab. session 11.01.42.91.41.01.71.51.51.0-0.9-1.4-0.91.0-1.0-0.80.7
Time in familiar zone, hab. session 20.60.61.0-1.0-0.8-0.7-1.0-1.0-0.70.80.70.7-0.70.60.6-0.6
Time in novel zone, hab. session 20.00.00.20.40.2-0.10.30.30.2-0.10.0-0.10.10.00.00.0
Total zone transitions, hab. session 20.30.40.80.60.80.60.40.40.9-0.8-0.3-0.80.9-0.5-0.50.6
Total locomotion distance, hab. session 21.21.62.90.71.50.90.60.61.7-1.4-0.5-1.41.4-1.5-1.61.6
Locomotion velocity, hab. session 21.11.52.60.81.51.10.80.81.6-1.3-0.8-1.31.3-1.4-1.51.4
Novel to familiar place preference ratio0.60.72.1-1.1-0.1-1.5-1.3-1.30.1-0.31.4-0.30.30.0-0.30.5
Novelty place preference0.70.72.2-1.2-0.2-1.5-1.3-1.30.0-0.21.4-0.20.20.1-0.20.4
Time in novel zone, NPP test0.91.03.1-1.4-0.4-1.8-1.6-1.6-0.2-0.01.7-0.00.00.3-0.00.2
Total zone transitions, NPP test0.40.61.00.61.00.90.60.60.9-0.7-1.0-0.70.8-0.9-0.80.7
Total locomotion distance, NPP test0.70.91.70.61.20.90.60.61.3-0.9-0.8-0.90.9-1.2-1.21.1
Locomotion velocity, NPP test1.21.72.41.11.51.41.21.21.5-1.1-1.4-1.21.2-1.5-1.41.2
Intraocular pressure2.02.84.51.31.81.11.31.31.7-2.1-1.0-2.12.1-1.8-1.81.9
Delta distance traveled before/after self-admin0.40.41.5-0.3-0.9-0.1-0.1-0.1-1.20.7-0.30.7-0.50.50.7-0.7
Delta ambulatory time before/after self-admin0.10.20.90.1-0.60.10.30.3-0.90.3-0.40.4-0.20.30.4-0.5
Parametrial fat weight0.20.40.91.00.7-0.10.70.70.8-0.80.4-0.80.8-0.2-0.30.6
Pavlov. Cond. lever latency0.50.71.50.20.8-0.10.30.31.0-0.9-0.2-0.90.9-1.1-1.21.2
Pavlov. Cond. magazine entry latency0.10.10.3-0.1-0.3-0.0-0.2-0.2-0.50.40.30.4-0.50.40.4-0.4
Pavlov. Cond. change in total contacts0.10.10.30.20.30.20.00.00.3-0.60.1-0.60.5-0.2-0.30.5
Pavlov. Cond. index score0.30.40.7-0.4-0.6-0.3-0.6-0.6-0.80.60.50.6-0.70.80.8-0.7
Pavlov. Cond. latency score0.40.51.0-0.4-0.7-0.3-0.6-0.6-0.90.70.50.8-0.81.01.0-0.9
Pavlov. Cond. lever contacts0.20.30.7-0.1-0.50.2-0.2-0.2-0.70.60.00.6-0.60.80.9-0.8
Pavlov. Cond. magazine entry number0.60.81.30.50.90.50.60.61.1-1.0-0.6-1.01.1-1.0-1.01.0
Pavlov. Cond. intertrial magazine entries0.40.51.2-0.30.8-0.4-0.5-0.51.1-0.70.2-0.60.7-0.7-0.80.9
Pavlov. Cond. lever-magazine prob. diff.0.10.10.2-0.3-0.3-0.2-0.5-0.5-0.40.20.50.2-0.30.50.4-0.3
Pavlov. Cond. response bias0.20.20.4-0.2-0.4-0.1-0.3-0.3-0.50.40.40.4-0.50.70.6-0.5
Pavlov. Cond. lever latency0.50.61.40.40.90.40.30.31.0-1.2-0.3-1.11.2-0.7-0.81.0
Pavlov. Cond. magazine entry latency0.60.71.30.4-0.80.40.60.6-1.01.1-0.51.0-1.10.70.9-1.2
Pavlov. Cond. change in total contacts0.50.81.0-0.8-0.9-1.0-0.7-0.7-1.01.00.81.0-1.00.80.7-0.8
Pavlov. Cond. index score0.40.51.0-0.2-0.9-0.4-0.2-0.2-1.01.00.30.9-0.90.80.9-0.9
Pavlov. Cond. latency score0.20.30.6-0.0-0.7-0.10.00.0-0.80.70.10.7-0.70.60.6-0.7
Pavlov. Cond. lever contacts1.01.42.3-0.9-1.3-1.0-0.8-0.8-1.41.50.81.5-1.51.11.1-1.2
Pavlov. Cond. magazine entry number0.70.81.70.01.10.1-0.2-0.21.3-1.20.0-1.21.2-0.9-1.01.2
Pavlov. Cond. intertrial magazine entries2.23.35.01.22.10.91.01.02.1-2.2-1.1-2.22.2-2.1-2.12.2
Pavlov. Cond. lever-magazine prob. diff.0.20.30.6-0.0-0.7-0.20.00.0-0.80.80.20.7-0.70.60.7-0.8
Pavlov. Cond. response bias1.41.93.7-0.5-1.5-0.6-0.4-0.4-1.71.90.41.9-1.91.41.5-1.8
Time in closed arm before self-admin0.81.02.3-1.4-0.8-1.2-1.5-1.5-0.70.21.50.2-0.30.90.7-0.4
Time in closed arm after self-admin1.11.21.7-1.1-1.2-0.7-1.0-1.0-1.31.01.01.0-1.01.31.3-1.2
Time in open arm before self-admin0.91.01.30.71.00.70.90.91.1-1.2-1.0-1.11.1-1.1-1.11.0
Time in open arm after self-admin0.00.00.10.2-0.20.20.10.1-0.20.3-0.40.3-0.30.10.1-0.2
Bone: periosteal estimation0.00.10.20.2-0.3-0.10.10.1-0.20.10.40.1-0.10.50.5-0.3
Bone: periosteal perimeter0.10.20.7-0.5-0.3-0.8-0.6-0.6-0.20.10.80.3-0.30.50.3-0.1
Bone: post-yield work0.20.20.80.90.10.80.70.7-0.00.1-0.70.0-0.00.20.3-0.4
Progressive ratio test 1 active lever presses0.81.01.71.11.1-0.20.80.81.2-1.30.1-1.31.3-0.8-0.91.1
Progressive ratio test 1 breakpoint0.70.91.51.01.1-0.40.60.61.2-1.20.2-1.21.2-0.7-0.91.0
Progressive ratio test 1 inactive lever presses0.30.52.31.50.1-0.21.31.30.2-0.50.0-0.40.50.30.4-0.1
Progressive ratio test 2 active lever presses0.20.20.40.30.50.10.40.40.4-0.4-0.5-0.50.5-0.6-0.60.4
Progressive ratio test 2 breakpoint0.20.30.50.40.60.10.40.40.5-0.5-0.6-0.60.5-0.7-0.70.5
Progressive ratio test 2 inactive lever presses0.10.20.90.9-0.1-0.00.90.9-0.30.1-0.30.1-0.10.40.4-0.4
Incentive Sensitization - Responses0.20.30.6-0.7-0.30.3-0.3-0.3-0.70.6-0.70.6-0.6-0.00.1-0.5
Incentive Sensitization - Breakpoint0.20.20.7-0.6-0.30.4-0.2-0.2-0.60.5-0.80.5-0.5-0.10.1-0.4
Sum of active levers in priming session hrs 5-62.62.45.4-2.2-1.2-2.0-2.3-2.3-0.91.12.01.2-1.11.00.8-0.7
Progressive ratio1.72.64.70.22.00.80.20.22.0-2.0-0.6-2.02.2-1.9-2.02.1
Food seeking constrained by brief footshock0.10.10.20.00.30.40.20.20.0-0.1-0.5-0.10.2-0.4-0.40.3
Seeking ratio, punishment vs. effort0.60.91.80.2-1.2-0.20.30.3-1.31.10.11.1-1.31.11.2-1.3
Retroperitoneal fat weight0.62.77.12.71.71.12.32.31.7-1.6-0.9-1.51.4-1.0-1.11.3
Reaction time number correct1.01.92.71.41.51.71.31.31.5-1.4-1.2-1.31.2-1.4-1.41.3
Reaction time mean minus median0.92.43.9-2.0-1.4-1.4-1.8-1.8-1.31.71.21.7-1.61.31.2-1.3
Reaction time mean minus median AUC0.82.03.0-1.7-1.3-1.2-1.6-1.6-1.31.71.11.6-1.71.11.1-1.2
Reaction time num false alarms1.62.33.91.91.62.01.51.51.6-1.4-1.3-1.31.4-1.4-1.41.3
Reaction time num false alarms AUC2.23.45.52.41.92.32.02.01.8-1.7-1.6-1.61.7-1.7-1.61.6
Reaction time trials correct on left1.01.92.71.41.51.71.31.31.5-1.4-1.2-1.31.2-1.4-1.41.3
Reaction time trials on left0.91.72.51.41.51.61.21.21.4-1.3-1.2-1.21.1-1.4-1.31.2
Reaction time mean2.54.05.6-2.3-2.1-2.4-2.2-2.2-1.72.02.21.8-1.91.91.7-1.6
Reaction time mean AUC1.82.84.3-1.9-1.7-2.1-1.9-1.9-1.31.72.01.5-1.51.51.4-1.3
Median of all reaction times2.43.45.8-2.1-2.0-2.4-2.0-2.0-1.51.72.21.5-1.61.81.6-1.5
Reaction time omissions1.11.62.8-1.5-1.5-1.0-1.1-1.1-1.71.40.71.3-1.31.11.1-1.2
Reaction time false alarm rate0.70.91.81.30.91.41.11.10.9-0.8-0.9-0.70.8-0.8-0.80.7
Reaction time premature initiation rate0.10.20.40.1-0.4-0.2-0.0-0.0-0.60.60.10.5-0.60.60.6-0.5
Reaction time premature initiations0.10.10.60.80.30.50.60.60.0-0.1-0.4-0.2-0.0-0.1-0.10.1
Std. dev. reaction times2.24.06.7-2.6-2.0-1.8-2.2-2.2-1.82.31.52.2-2.21.61.6-1.7
Reaction time trials completed0.91.72.51.41.51.61.21.21.4-1.3-1.2-1.21.1-1.4-1.31.2
Reaction time trials AUC0.81.62.31.31.41.51.11.11.4-1.3-1.1-1.21.1-1.3-1.31.2
Run reversals in cocaine runway, females0.50.50.80.80.80.70.60.60.7-0.6-0.9-0.70.7-0.8-0.80.7
Run reversals in cocaine runway, males0.20.20.50.20.3-0.30.20.20.3-0.70.4-0.70.6-0.2-0.30.5
Latency to leave start box in cocaine runway2.42.86.62.61.61.92.32.31.3-1.4-1.7-1.51.5-0.9-0.70.8
Latency to leave start box in cocaine runway, F0.70.82.31.50.51.21.51.50.3-0.3-1.3-0.30.4-0.10.1-0.1
Latency to leave start box in cocaine runway, M4.64.35.82.42.32.31.91.92.1-2.2-1.7-2.42.3-1.8-1.71.8
Std. dev. time between licks in bursts0.70.91.40.61.10.90.50.51.2-1.0-0.4-1.21.1-1.1-1.21.2
Total sessions with >9 infusions1.01.22.11.41.00.21.21.21.1-1.4-0.1-1.41.4-0.8-0.91.2
Short access day 1 total inactive lever presses0.81.03.51.80.50.61.91.90.3-0.6-1.0-0.70.5-0.4-0.30.3
Short access day 10 total inactive lever presses0.20.41.1-0.1-1.0-0.30.10.1-1.00.5-0.10.6-0.60.70.8-0.8
Short access day 1 total infusions1.01.31.91.31.00.61.41.40.9-1.3-0.6-1.41.3-1.0-1.01.1
Short access day 10 total infusions0.60.82.1-0.10.5-1.4-0.3-0.30.9-1.01.4-1.00.9-0.5-0.91.1
Short access total infusions0.60.81.80.40.7-0.60.40.40.9-1.30.7-1.41.3-0.6-0.91.1
Short access day 1 locomotion1.61.93.31.81.41.11.71.71.3-1.5-0.9-1.51.5-1.2-1.21.2
Short access day 10 total locomotion0.00.00.10.1-0.1-0.3-0.1-0.10.0-0.00.0-0.0-0.0-0.0-0.10.1
Short access total locomotion1.61.93.31.81.41.11.51.51.4-1.4-1.1-1.41.3-1.3-1.31.3
One hour access (0.3 mA shock)1.51.87.4-1.5-0.5-2.7-1.8-1.80.1-0.42.4-0.40.40.50.00.4
Compulsive drug intake0.10.10.50.20.30.50.40.40.10.2-0.70.2-0.3-0.4-0.3-0.1
One hour access (shock baseline)0.81.24.9-1.1-0.8-2.2-1.3-1.3-0.4-0.02.10.00.10.60.20.1
Social response proportion0.30.40.8-0.7-0.5-0.8-0.9-0.9-0.60.10.6-0.2-0.10.80.7-0.5
Social responses1.11.42.3-1.1-1.2-1.5-1.4-1.4-1.20.91.50.8-1.01.31.2-1.0
Social time4.66.38.2-2.5-2.7-2.2-2.5-2.5-2.72.42.32.3-2.42.92.7-2.6
Soleus weight1.33.75.92.02.32.42.12.11.9-1.6-2.1-1.61.5-1.9-1.81.5
Bone: stiffness0.71.13.41.90.61.51.71.70.4-0.6-1.2-0.70.7-0.10.10.0
Tibialis anterior weight3.110.413.62.93.43.53.23.23.0-2.9-3.7-2.92.8-3.7-3.53.0
Time to tail flick, vehicle, before self-admin0.40.41.5-0.6-0.3-1.2-0.8-0.8-0.20.11.10.2-0.10.60.4-0.2
Time to tail flick, vehicle, after self-admin0.30.41.1-1.1-0.6-0.4-0.9-0.9-0.50.40.50.4-0.30.50.5-0.4
Time to tail flick, test, before self-admin2.12.24.30.62.01.61.11.11.7-1.0-1.7-1.01.0-2.1-2.01.6
Time to tail flick, test, after self-admin2.72.85.92.41.70.92.02.01.8-1.8-0.4-1.81.8-1.2-1.31.6
Delta time to tail flick, vehicle, before/after SA0.00.00.3-0.10.00.60.10.10.00.0-0.4-0.00.1-0.2-0.1-0.0
Delta time to tail flick, test, before/after SA0.40.51.51.0-0.5-1.00.40.4-0.0-0.31.2-0.30.30.90.8-0.3
Tibia length0.20.61.70.0-0.8-0.3-0.1-0.1-0.90.80.40.8-0.81.31.3-1.1
Ambulatory time before self-admin0.81.21.9-0.8-1.1-0.7-1.0-1.0-0.81.31.01.3-1.41.31.3-1.2
Ambulatory time after self-admin2.02.34.0-0.7-1.9-0.4-0.7-0.7-2.01.80.51.8-1.81.82.0-2.0
Bone: tissue strength0.20.20.40.60.60.10.50.50.7-0.4-0.3-0.30.3-0.3-0.30.3
Total heroin consumption1.51.76.6-1.5-0.5-2.6-1.9-1.9-0.1-0.32.3-0.20.20.50.10.4
Bone: trabecular number3.55.88.7-1.4-2.7-1.5-1.3-1.3-2.62.81.82.9-2.92.93.0-2.9
Bone: trabecular spacing2.33.14.41.31.91.71.11.11.7-2.1-1.7-2.12.1-1.9-1.81.9
Bone: trabecular thickness5.67.09.0-2.2-2.9-2.4-2.1-2.1-2.63.02.53.0-3.02.92.8-2.8
Bone: trabecular tissue density0.20.31.20.3-0.20.70.50.5-0.50.5-1.10.4-0.4-0.00.2-0.5
Water consumed over 24 hours0.10.10.3-0.30.1-0.3-0.5-0.50.3-0.30.5-0.40.30.0-0.10.2
Number of responses in last shaping day0.10.10.20.2-0.5-0.20.20.2-0.40.10.1-0.1-0.20.30.3-0.2