Hub : Genes

Nck2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Nck2 0.83 0.06 0.0e+00 0.38 0.39 0.38 0.37 3.1e-44 1.3e-45 4.2e-44 2.2e-43
2 Brain mRNA stability Nck2 0.1 0.06 4.7e-10 0.1 0.1 0.1 0.1 6.6e-10 1.9e-09 5.6e-10 5.6e-10
3 Liver mRNA stability Nck2 0.31 0.16 5.9e-13 0.08 0.08 0.08 0.08 1.5e-09 2.2e-09 6.6e-09 1.4e-09
4 Liver alternative TSS NM_001108216.1 0.07 0.04 6.0e-04 0.03 0.02 0.02 0.02 7.4e-04 2.2e-03 1.1e-03 9.1e-04
5 Liver alternative TSS XM_006244825.5 0.08 0.05 2.1e-04 0.03 0.02 0.02 0.02 4.1e-04 2.5e-03 2.8e-03 1.1e-03
6 IL mRNA stability Nck2 0.23 0.14 1.3e-03 0.11 0.08 0.09 0.03 1.6e-03 5.9e-03 4.5e-03 5.5e-02
7 pVTA gene expression Nck2 0.12 0.07 2.4e-06 0.06 0.06 0.04 0.06 5.6e-06 1.1e-05 1.6e-04 3.0e-05
8 Liver alternative TSS XM_063267164.1 0.07 0.05 3.8e-04 0.02 0.02 0.02 0.02 1.2e-03 3.1e-03 3.7e-03 1.7e-03
9 Liver alternative TSS XM_063267164.1 0.09 0.06 4.7e-05 0.03 0.03 0.02 0.03 4.5e-04 6.0e-04 1.0e-03 6.1e-04
10 Brain gene expression Nck2 0.21 0.14 2.7e-06 0.06 0.06 0.06 0.06 1.8e-06 3.0e-06 7.3e-06 4.2e-06
11 BLA mRNA stability Nck2 0.12 0.1 2.7e-04 0.09 0.07 0.06 0.04 2.7e-05 1.4e-04 4.3e-04 3.6e-03
12 Adipose gene expression Nck2 0.05 0.03 5.4e-06 0.03 0.03 0.01 0.03 3.2e-04 2.8e-04 6.8e-03 4.2e-04
13 IL intron excision ratio chr9_53295118_53316117 0.17 0.12 6.5e-03 -0.01 0.03 0.01 -0.01 7.7e-01 6.9e-02 2.2e-01 6.0e-01
14 PL mRNA stability Nck2 0.07 0.04 5.6e-09 0.06 0.07 0.06 0.04 1.4e-07 9.8e-08 3.5e-07 9.2e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density3.87.110.1-1.9-3.0-1.91.81.82.9-3.1-2.1-2.1-3.23.23.13.1-3.1
Area under the delay curve0.30.51.1-0.40.4-0.60.70.7-0.50.7-0.8-0.80.6-0.7-0.7-1.01.0
BMI with tail1.03.45.32.22.11.5-1.8-1.8-2.22.30.80.82.3-2.2-1.5-1.51.9
BMI without tail0.10.51.6-0.60.3-0.40.80.8-0.50.5-1.3-1.30.5-0.4-0.2-0.40.6
Body weight0.10.20.60.10.5-0.10.20.2-0.70.7-0.8-0.80.6-0.60.1-0.00.4
Weight adjusted by age0.61.84.71.61.12.2-1.6-1.6-1.00.52.12.10.3-0.4-0.9-0.60.4
Bone surface0.30.60.9-0.5-0.8-0.60.40.40.8-0.8-0.7-0.7-0.80.80.90.9-0.8
Bone volume1.63.34.9-1.3-2.1-1.31.21.22.0-2.0-1.5-1.5-2.12.12.22.2-2.1
Breakpoint value in progressive ratio session1.01.73.4-1.8-1.1-1.81.71.71.0-0.8-1.6-1.6-0.90.81.00.9-0.7
Number of licking bursts0.20.51.9-1.4-0.3-0.81.31.30.3-0.4-0.6-0.6-0.40.40.10.1-0.1
Context. condit. distance diff. score0.80.92.0-0.1-1.2-0.30.20.21.2-1.2-0.7-0.7-1.01.01.41.4-1.3
Locomotion velocity, session 10.00.00.1-0.30.0-0.30.40.4-0.00.1-0.2-0.20.1-0.10.0-0.00.1
Locomotion distance, session 11.41.82.61.61.31.6-1.5-1.5-1.21.11.51.51.3-1.2-1.1-1.00.9
Locomotion velocity, session 23.64.35.51.92.41.8-1.9-1.9-2.32.22.02.02.1-2.1-2.3-2.22.1
Locomotion distance, session 23.24.46.12.12.41.8-1.9-1.9-2.52.31.51.52.4-2.4-2.2-2.22.2
Locomotion velocity, session 30.10.10.2-0.1-0.40.1-0.1-0.10.3-0.40.10.1-0.20.30.30.4-0.4
Locomotion distance, session 30.20.20.4-0.4-0.6-0.50.30.30.5-0.4-0.3-0.3-0.30.40.40.5-0.4
Stereotopy head waving bouts, day 30.30.30.6-0.3-0.8-0.20.40.40.7-0.6-0.7-0.7-0.60.50.60.5-0.5
Stereotopy head waving duration, day 30.20.30.4-0.5-0.6-0.20.50.50.5-0.6-0.6-0.6-0.60.50.40.3-0.4
Locomotion velocity, session 71.71.93.91.81.01.9-1.9-1.9-0.80.52.02.00.6-0.5-1.1-0.80.5
Locomotion distance, session 70.81.01.51.21.01.0-1.2-1.2-1.00.91.01.00.8-0.8-1.1-1.00.9
Stereotopy head waving bouts, day 70.10.20.5-0.1-0.6-0.20.10.10.7-0.5-0.3-0.3-0.40.40.50.5-0.5
Stereotopy head waving duration, day 70.20.20.60.2-0.60.2-0.2-0.20.8-0.60.20.2-0.40.50.50.7-0.7
Locomotion velocity, session 80.40.51.31.00.21.0-1.0-1.0-0.0-0.01.21.20.1-0.10.10.4-0.4
Locomotion distance, session 80.91.43.61.90.91.4-1.7-1.7-0.90.81.21.21.1-1.0-0.5-0.30.4
Degree of sensitization distance1.21.32.21.11.30.9-0.9-0.9-1.31.20.70.71.0-1.2-1.4-1.51.4
Degree of sensitization stereotypy0.10.10.20.3-0.30.0-0.2-0.20.4-0.20.10.1-0.10.10.30.4-0.3
Conditioned locomotion0.40.51.4-0.8-0.4-0.90.90.90.00.2-1.2-1.20.2-0.20.70.5-0.1
Cocaine response after cond. corrected0.40.61.3-0.30.6-0.80.50.5-1.00.9-0.6-0.61.0-1.0-0.8-1.01.2
Cocaine response after cond. not corrected0.30.41.0-0.10.7-0.50.20.2-0.90.9-0.3-0.30.9-0.9-0.7-0.81.0
Cocaine response before conditioning0.40.41.30.80.21.0-0.8-0.80.0-0.11.11.1-0.20.10.00.2-0.3
Saline control response0.71.01.91.40.71.3-1.4-1.4-0.50.71.31.30.8-0.8-0.6-0.40.4
Bone: connectivity density0.81.41.8-1.0-1.2-0.90.90.91.2-1.3-1.1-1.1-1.31.31.31.3-1.2
Bone: cortical apparent density3.55.69.22.82.12.9-3.0-3.0-1.71.73.03.01.7-1.7-2.0-1.71.4
Bone: cortical area0.10.20.60.80.40.5-0.7-0.7-0.20.40.40.40.3-0.30.00.10.1
Bone: cortical porosity1.51.62.4-1.3-1.3-1.11.11.11.5-1.5-0.8-0.8-1.51.51.31.3-1.4
Bone: cortical porosity1.71.92.8-1.1-1.5-1.01.01.01.7-1.7-0.8-0.8-1.71.71.51.5-1.6
Bone: cortical thickness0.10.20.50.70.40.4-0.6-0.6-0.20.40.50.50.4-0.40.10.10.0
Bone: cortical thickness0.10.10.30.50.20.3-0.4-0.4-0.20.40.20.20.4-0.4-0.0-0.00.2
Bone: cortical tissue density3.25.28.92.72.02.9-3.0-3.0-1.61.53.03.01.6-1.6-1.8-1.51.3
Condit. Reinf. active minus inactive responses0.20.20.3-0.10.4-0.60.50.5-0.50.3-0.4-0.40.4-0.3-0.4-0.50.6
Condit. Reinf. active-inactive response ratio0.20.20.8-0.3-0.1-0.90.70.70.10.0-0.6-0.60.2-0.1-0.0-0.20.3
Condit. Reinf. active responses0.10.10.50.30.6-0.10.10.1-0.70.3-0.1-0.10.5-0.4-0.4-0.50.5
Condit. Reinf. inactive responses0.60.81.60.91.10.8-0.8-0.8-1.20.90.70.71.0-0.9-0.9-0.90.9
Incentive salience index mean0.00.00.10.00.1-0.30.40.4-0.0-0.0-0.2-0.20.1-0.00.1-0.00.1
Condit. Reinf. lever presses0.10.20.60.2-0.40.3-0.0-0.00.7-0.50.10.1-0.40.40.70.8-0.7
Condit. Reinf. active minus inactive responses0.50.71.6-1.2-0.6-1.21.21.20.5-0.6-1.1-1.1-0.60.60.40.3-0.3
Condit. Reinf. active-inactive response ratio1.32.03.0-1.7-1.5-1.71.71.71.3-1.1-1.6-1.6-1.11.11.31.1-1.0
Condit. Reinf. active responses0.20.20.4-0.40.5-0.50.50.5-0.60.3-0.5-0.50.3-0.3-0.5-0.60.6
Condit. Reinf. inactive responses1.21.82.91.41.71.4-1.4-1.4-1.51.11.31.31.0-1.0-1.4-1.41.2
Condit. Reinf. lever presses0.30.50.9-0.9-0.6-0.90.80.80.6-0.7-0.7-0.7-0.70.70.40.3-0.4
Condit. Reinf. lever reinforcers received0.20.30.7-0.30.6-0.40.40.4-0.80.5-0.3-0.30.5-0.5-0.7-0.80.8
Conditioned reinforcement - actives0.00.10.5-0.2-0.1-0.7-0.1-0.1-0.10.4-0.5-0.50.4-0.4-0.2-0.30.4
Conditioned reinforcement - inactives0.10.31.31.10.10.1-1.2-1.2-0.00.30.40.40.3-0.20.10.1-0.1
Conditioned locomotion1.11.64.42.10.71.0-2.1-2.1-0.81.20.90.91.1-1.2-0.7-0.60.7
Patch foraging indifference point 0 sec0.31.02.41.20.51.4-1.5-1.5-0.30.41.51.50.3-0.4-0.5-0.30.1
Patch foraging indifference point AUC0.20.61.30.70.70.1-0.5-0.5-0.81.10.20.21.1-1.1-0.8-0.91.0
Delay disc. indifference point, 0s delay0.81.02.11.30.81.3-1.1-1.1-0.30.61.41.40.6-0.6-0.9-0.70.5
Delay disc. indifference point, 16s delay0.91.33.6-1.4-0.8-1.91.61.60.3-0.4-1.8-1.8-0.40.30.50.2-0.1
Delay disc. indifference point, 2s delay0.30.30.80.50.3-0.4-0.2-0.2-0.30.7-0.5-0.50.6-0.6-0.6-0.80.9
Delay disc. indifference point, 24s delay0.10.10.3-0.5-0.3-0.60.60.6-0.1-0.3-0.4-0.4-0.20.20.0-0.0-0.1
Delay disc. indifference point, 4s delay0.50.61.11.00.70.8-0.7-0.7-0.50.90.40.40.8-0.8-0.8-0.80.8
Delay disc. indifference point, 8s delay0.20.30.9-0.80.0-0.60.90.9-0.00.2-0.8-0.80.1-0.2-0.4-0.60.6
Indifference point function ln k0.30.91.9-0.01.21.1-0.3-0.3-1.30.61.31.30.5-0.5-1.4-1.31.0
Indifference point function log k0.30.91.9-0.01.21.1-0.3-0.3-1.30.61.31.30.5-0.5-1.4-1.31.0
Patch foraging total patch changes 0 sec0.31.02.41.30.71.2-1.5-1.5-0.60.71.21.20.6-0.7-0.6-0.50.4
Patch foraging total patch changes 12 sec0.20.30.80.8-0.60.3-0.9-0.90.80.10.40.40.0-0.10.50.6-0.5
Patch foraging total patch changes 18 sec0.41.01.70.71.10.6-0.8-0.8-1.11.30.70.71.3-1.3-1.0-1.11.1
Patch foraging total patch changes 24 sec0.30.92.81.70.21.0-1.7-1.7-0.10.60.90.90.7-0.7-0.1-0.10.1
Patch foraging total patch changes 6 sec0.30.41.61.20.10.5-1.3-1.3-0.00.00.60.60.1-0.1-0.1-0.0-0.1
Patch foraging time to switch 0 sec0.31.01.8-0.8-1.3-0.70.50.51.3-1.2-0.5-0.5-1.11.21.11.2-1.3
Patch foraging water rate 0 sec0.20.71.5-0.10.8-0.10.30.3-1.21.2-0.4-0.41.1-1.1-0.8-1.01.2
Patch foraging water rate 12 sec0.10.20.60.00.70.20.00.0-0.70.40.20.20.4-0.4-0.7-0.80.6
Patch foraging water rate 18 sec0.10.20.5-0.7-0.20.30.60.60.4-0.70.10.1-0.70.7-0.00.0-0.3
Patch foraging water rate 24 sec0.10.10.40.20.40.6-0.1-0.1-0.4-0.20.20.2-0.10.2-0.5-0.50.3
Patch foraging water rate 6 sec0.20.31.0-0.40.80.40.50.5-0.60.10.40.40.2-0.1-1.0-1.00.8
Seeking ratio, delayed vs. immediate footshock0.50.61.5-0.6-0.9-0.20.70.70.8-0.6-0.7-0.7-0.70.71.21.2-0.9
Distance traveled before self-admin0.61.42.3-0.7-1.2-0.60.80.81.0-1.4-1.1-1.1-1.41.51.51.5-1.4
Distance traveled after self-admin2.54.47.8-1.1-2.6-0.71.01.02.7-2.5-1.0-1.0-2.62.52.72.8-2.7
Extensor digitorum longus weight7.329.134.95.35.95.6-5.3-5.3-5.55.25.55.55.1-5.1-5.7-5.45.1
Bone: elastic displacement1.52.03.7-1.9-1.1-1.91.81.80.8-1.2-1.6-1.6-1.31.30.90.8-0.8
Bone: elastic work0.91.21.7-1.1-0.9-1.31.11.10.7-0.9-1.3-1.3-1.11.11.21.1-0.9
Bone: endosteal estimation0.00.10.4-0.1-0.3-0.30.10.10.10.0-0.6-0.6-0.10.10.20.1-0.0
Bone: endosteal perimeter0.00.10.2-0.2-0.2-0.40.20.20.1-0.0-0.5-0.5-0.10.10.20.10.0
Epididymis fat weight0.10.50.90.60.90.3-0.8-0.8-0.91.00.20.20.7-0.7-0.8-0.91.0
Delta time in closed arm before/after self-admin0.30.30.8-0.9-0.3-0.70.70.70.3-0.6-0.4-0.4-0.70.60.10.1-0.3
Delta time in open arm before/after self-admin0.10.10.20.4-0.2-0.10.10.10.1-0.4-0.2-0.2-0.40.50.30.3-0.3
Diff in mean of infusions in LGA sessions0.40.81.9-1.0-0.5-1.11.41.40.3-0.4-1.1-1.1-0.40.50.80.7-0.5
Delay discount exponential model param0.40.51.10.4-0.40.6-0.7-0.70.5-0.70.90.9-0.60.70.71.0-1.0
Extinction: sum of active levers before priming1.82.76.5-1.0-1.7-2.31.31.31.3-0.9-2.5-2.5-0.90.72.11.8-1.2
Active lever presses in extinction session 60.50.51.00.40.8-0.60.00.0-0.91.0-0.8-0.80.9-1.0-0.4-0.71.0
Bone: final force0.20.41.61.20.30.7-1.1-1.1-0.20.20.40.40.2-0.20.30.4-0.2
Bone: final moment0.20.31.41.20.30.6-1.0-1.0-0.30.20.40.40.2-0.20.20.2-0.1
Food consumed during 24 hour testing period0.30.51.20.60.70.4-0.4-0.4-0.91.00.10.11.0-1.1-0.8-0.81.0
Glucose0.40.61.4-1.2-0.7-1.21.01.00.5-0.4-1.1-1.1-0.30.30.50.3-0.2
Heart weight0.10.10.3-0.50.40.20.30.3-0.40.30.10.10.3-0.1-0.5-0.60.5
Delay discount hyperbolic model param0.40.51.20.2-0.50.4-0.5-0.50.5-0.70.80.8-0.70.70.81.0-1.1
Intermittent access intake day 1-15 change0.10.51.2-0.4-1.0-0.10.20.21.1-1.0-0.0-0.0-1.01.00.80.8-0.9
Intermittent access intake escalation0.10.61.4-0.3-1.1-0.00.10.11.2-1.10.10.1-1.11.10.80.9-1.0
Intermittent access intake escalation 20.81.42.6-1.2-1.3-0.51.11.11.3-1.6-0.6-0.6-1.61.51.11.1-1.3
Intermitt. access day 1 inactive lever presses0.00.51.40.4-1.0-1.2-0.3-0.30.7-0.2-0.7-0.7-0.30.20.90.9-0.6
Intermitt. access day 15 inactive lever presses0.10.51.51.1-0.10.5-1.2-1.20.20.11.01.00.1-0.0-0.10.1-0.2
Intermitt. access escalation Index0.10.20.50.40.60.7-0.2-0.2-0.4-0.40.50.5-0.40.4-0.3-0.1-0.1
Intermittent access day 1 total infusions0.51.45.3-0.7-0.2-2.31.11.1-0.30.7-2.2-2.20.7-0.60.3-0.10.5
Intermittent access day 15 total infusions0.20.61.5-0.6-0.9-1.20.60.60.8-0.6-1.0-1.0-0.60.60.70.5-0.5
Intermittent access terminal intake (last 3 days)0.20.41.7-0.3-0.3-1.30.50.50.1-0.0-1.2-1.2-0.10.00.40.2-0.1
Intermittent access total infusions0.60.72.9-0.8-0.7-1.70.90.90.4-0.0-1.4-1.4-0.10.10.40.2-0.0
Intermittent access day 1 locomotion0.20.40.90.50.6-0.7-0.1-0.1-0.80.9-0.6-0.60.9-0.9-0.3-0.50.7
Intermittent access day 15 total locomotion0.10.30.40.60.50.3-0.5-0.5-0.50.60.60.60.6-0.6-0.7-0.60.6
Intermittent access total locomotion0.30.30.80.50.5-0.2-0.3-0.3-0.60.90.20.20.9-0.9-0.6-0.70.7
Intermittent access standard deviation0.20.92.0-0.8-1.4-1.10.50.51.1-0.7-1.2-1.2-0.70.61.11.0-0.8
Left kidney weight0.10.51.0-1.0-0.7-0.00.70.70.8-0.6-0.3-0.3-0.60.60.90.9-0.9
Right kidney weight0.10.51.61.00.31.3-1.0-1.00.10.31.01.00.3-0.30.20.4-0.3
Cocaine induced anxiety0.30.81.81.20.61.1-1.3-1.3-0.40.21.41.40.2-0.2-0.6-0.40.1
Post-drug Anxiety1.31.53.61.90.91.4-1.8-1.8-0.71.11.21.21.1-1.0-0.8-0.70.7
Baseline Anxiety0.30.51.50.40.3-0.3-0.2-0.2-0.51.2-0.8-0.81.2-1.1-0.4-0.60.9
Tail length0.84.59.2-3.0-1.8-2.42.92.91.5-1.3-2.7-2.7-1.41.41.61.3-1.1
Length with tail0.62.84.2-2.0-1.6-1.92.02.01.2-1.2-2.1-2.1-1.31.31.71.5-1.3
Length without tail0.00.10.40.70.20.1-0.6-0.6-0.10.40.10.10.3-0.30.10.10.0
Times rat made contact with spout1.41.63.6-1.8-0.8-1.61.91.90.5-0.6-1.9-1.9-0.50.50.70.4-0.2
Lifetime Intake0.30.41.9-0.3-0.4-1.40.30.30.20.4-1.1-1.10.4-0.40.2-0.10.3
Liver weight, left0.50.82.4-1.1-0.1-1.51.31.3-0.10.1-1.5-1.5-0.10.00.3-0.00.2
Liver weight, right0.61.03.5-0.9-0.7-1.21.21.20.4-0.3-1.9-1.9-0.40.30.90.7-0.4
Locomotor activity0.30.40.6-0.6-0.4-0.60.60.60.2-0.8-0.7-0.7-0.80.80.60.5-0.5
Locomotor testing distance0.81.93.0-1.1-1.4-1.11.21.21.3-1.7-1.1-1.1-1.71.71.51.5-1.6
Locomotor testing rearing0.72.54.5-1.0-1.9-0.81.01.02.1-2.1-0.7-0.7-2.02.11.71.8-1.9
Locomotion in novel chamber5.37.110.62.53.12.4-2.2-2.2-3.33.11.91.93.0-3.0-2.7-2.72.8
Locomotion in novel chamber post-restriction0.92.84.31.91.91.5-1.7-1.7-1.92.10.90.92.0-2.0-1.5-1.51.7
Fecal boli incidents, locomotor time 10.51.22.20.51.20.4-0.5-0.5-1.41.40.40.41.4-1.4-1.3-1.41.5
Change in fecal boli incidents, locomotor task0.10.10.4-0.0-0.4-0.60.10.10.5-0.2-0.3-0.3-0.20.20.50.5-0.4
Time >=10cm from walls, locomotor time 12.22.74.50.91.81.8-1.3-1.3-1.71.31.91.91.3-1.4-2.1-2.01.6
Bouts of movement, locomotor time 14.96.411.81.33.10.6-1.1-1.1-3.33.30.80.83.2-3.2-3.1-3.33.4
Total resting periods, locomotor time 16.06.911.91.63.20.9-1.4-1.4-3.43.41.11.13.3-3.3-3.2-3.33.4
Rest time, locomotor task time 10.61.02.6-0.70.2-1.31.01.0-0.30.9-1.6-1.60.9-0.9-0.3-0.71.0
Distance moved, locomotor task time 10.10.20.4-0.50.00.40.40.4-0.1-0.50.60.6-0.50.5-0.1-0.0-0.3
Vertical activity count, locomotor time 10.11.01.9-0.7-0.90.40.50.51.2-1.40.60.6-1.31.40.91.1-1.4
Time >=10cm from walls, locomotor time 20.00.10.4-0.5-0.0-0.40.60.60.0-0.1-0.2-0.2-0.0-0.1-0.0-0.00.0
Bouts of movement, locomotor time 20.82.74.81.51.91.1-1.3-1.3-2.22.00.80.82.0-1.9-1.6-1.71.8
Total resting periods, locomotor time 20.62.23.81.51.70.9-1.3-1.3-2.01.80.70.71.9-1.8-1.4-1.51.6
Rest time, locomotor task time 20.10.20.5-0.7-0.6-0.70.50.50.7-0.3-0.6-0.6-0.30.30.30.2-0.2
Distance moved, locomotor task time 20.50.61.30.21.10.80.00.0-1.00.70.80.80.6-0.6-1.1-1.00.9
Vertical activity count, locomotor time 20.20.51.30.90.91.1-0.6-0.6-0.60.61.01.00.6-0.6-0.5-0.40.4
Light reinforcement 11.56.912.23.52.42.5-3.4-3.4-2.02.82.22.22.6-2.7-2.3-2.22.3
Light reinforcement 20.81.73.51.91.31.2-1.7-1.7-1.01.50.50.51.4-1.5-1.0-1.11.2
Bone: marrow area0.00.00.3-0.0-0.2-0.20.00.0-0.00.1-0.5-0.5-0.00.00.10.00.1
Bone: maximum diameter0.10.20.4-0.2-0.4-0.30.10.10.4-0.2-0.5-0.5-0.30.30.60.6-0.4
Bone: maximum force0.20.41.81.30.50.7-1.1-1.1-0.40.40.50.50.4-0.40.10.20.0
Bone: maximum moment0.20.51.71.30.60.7-1.1-1.1-0.60.50.50.50.5-0.5-0.1-0.00.2
Mean time between licks in bursts0.31.92.21.31.41.5-1.5-1.5-1.21.31.51.51.3-1.3-1.4-1.31.2
Mean num. licks in bursts0.10.20.40.60.30.2-0.5-0.5-0.40.5-0.2-0.20.5-0.5-0.2-0.30.4
Cd content in liver3.84.37.2-2.2-1.9-2.62.52.51.6-1.6-2.7-2.7-1.61.61.81.6-1.4
Co content in liver1.21.52.7-1.4-1.0-1.61.51.50.7-0.9-1.6-1.6-0.90.91.00.8-0.7
Cu content in liver0.20.20.3-0.4-0.5-0.40.40.40.5-0.5-0.5-0.5-0.50.40.50.4-0.4
Fe content in liver2.83.44.6-1.6-2.1-1.61.61.62.1-1.8-1.7-1.7-1.81.82.12.1-2.0
K content in liver1.81.72.51.41.31.6-1.6-1.6-1.11.01.51.51.0-1.1-1.2-1.11.0
Mg content in liver0.30.30.70.60.30.8-0.8-0.8-0.20.10.80.80.0-0.1-0.4-0.30.2
Mn content in liver0.80.92.01.30.61.4-1.3-1.3-0.50.41.41.40.4-0.4-0.5-0.40.3
Na content in liver0.91.02.2-0.3-1.1-0.00.10.11.3-1.5-0.1-0.1-1.41.41.21.3-1.5
Rb content in liver5.56.47.82.82.62.4-2.4-2.4-2.52.72.32.32.8-2.8-2.4-2.42.4
Se content in liver0.50.51.30.50.80.4-0.3-0.3-0.91.10.20.21.1-1.1-0.6-0.70.9
Sr content in liver0.10.10.3-0.6-0.0-0.50.50.5-0.2-0.1-0.5-0.5-0.10.1-0.2-0.30.3
Zn content in liver0.10.20.3-0.4-0.5-0.30.40.40.4-0.5-0.4-0.4-0.50.40.30.3-0.3
Bone: minimum diameter0.50.91.91.41.01.0-1.2-1.2-0.91.00.60.60.9-0.9-0.6-0.60.7
Time in familiar zone, hab. session 10.80.92.7-1.0-0.4-1.61.21.2-0.00.0-1.6-1.6-0.10.10.50.20.1
Time in novel zone, hab. session 10.60.61.1-0.9-0.9-0.50.80.81.0-1.1-0.4-0.4-0.91.00.70.7-0.8
Total zone transitions, hab. session 10.60.82.01.1-0.01.4-1.3-1.30.3-0.31.41.4-0.30.30.00.3-0.6
Total locomotion distance, hab. session 11.01.42.21.31.11.5-1.3-1.3-1.21.01.21.21.0-1.1-1.1-1.00.9
Locomotion velocity, hab. session 11.01.52.91.41.01.7-1.5-1.5-1.00.91.41.40.9-1.0-1.0-0.80.7
Time in familiar zone, hab. session 20.50.61.0-1.0-0.8-0.71.01.00.7-0.8-0.7-0.7-0.70.70.60.6-0.6
Time in novel zone, hab. session 20.00.00.20.40.2-0.1-0.3-0.3-0.20.1-0.0-0.00.1-0.10.00.00.0
Total zone transitions, hab. session 20.30.40.80.60.80.6-0.4-0.4-0.90.80.30.30.8-0.9-0.5-0.50.6
Total locomotion distance, hab. session 21.11.52.90.71.50.9-0.6-0.6-1.71.40.50.51.4-1.4-1.5-1.61.6
Locomotion velocity, hab. session 21.11.42.60.81.51.1-0.8-0.8-1.61.30.80.81.3-1.3-1.4-1.51.4
Novel to familiar place preference ratio0.60.82.1-1.1-0.1-1.51.31.3-0.10.3-1.4-1.40.3-0.30.0-0.30.5
Novelty place preference0.60.82.2-1.2-0.2-1.51.31.3-0.00.2-1.4-1.40.2-0.20.1-0.20.4
Time in novel zone, NPP test0.91.13.1-1.4-0.4-1.81.61.60.20.0-1.7-1.70.0-0.00.3-0.00.2
Total zone transitions, NPP test0.40.61.00.61.00.9-0.6-0.6-0.90.71.01.00.7-0.8-0.9-0.80.7
Total locomotion distance, NPP test0.70.91.70.61.20.9-0.6-0.6-1.30.90.80.80.9-0.9-1.2-1.21.1
Locomotion velocity, NPP test1.21.72.41.11.51.4-1.2-1.2-1.51.11.41.41.2-1.2-1.5-1.41.2
Intraocular pressure1.62.74.51.31.81.1-1.3-1.3-1.72.11.01.02.1-2.1-1.8-1.81.9
Delta distance traveled before/after self-admin0.30.41.5-0.3-0.9-0.10.10.11.2-0.70.30.3-0.70.50.50.7-0.7
Delta ambulatory time before/after self-admin0.10.20.90.1-0.60.1-0.3-0.30.9-0.30.40.4-0.40.20.30.4-0.5
Parametrial fat weight0.20.40.91.00.7-0.1-0.7-0.7-0.80.8-0.4-0.40.8-0.8-0.2-0.30.6
Pavlov. Cond. lever latency0.50.61.50.20.8-0.1-0.3-0.3-1.00.90.20.20.9-0.9-1.1-1.21.2
Pavlov. Cond. magazine entry latency0.10.10.3-0.1-0.3-0.00.20.20.5-0.4-0.3-0.3-0.40.50.40.4-0.4
Pavlov. Cond. change in total contacts0.10.10.30.20.30.2-0.0-0.0-0.30.6-0.1-0.10.6-0.5-0.2-0.30.5
Pavlov. Cond. index score0.30.40.7-0.4-0.6-0.30.60.60.8-0.6-0.5-0.5-0.60.70.80.8-0.7
Pavlov. Cond. latency score0.40.51.0-0.4-0.7-0.30.60.60.9-0.7-0.5-0.5-0.80.81.01.0-0.9
Pavlov. Cond. lever contacts0.20.30.7-0.1-0.50.20.20.20.7-0.6-0.0-0.0-0.60.60.80.9-0.8
Pavlov. Cond. magazine entry number0.60.71.30.50.90.5-0.6-0.6-1.11.00.60.61.0-1.1-1.0-1.01.0
Pavlov. Cond. intertrial magazine entries0.40.41.2-0.30.8-0.40.50.5-1.10.7-0.2-0.20.6-0.7-0.7-0.80.9
Pavlov. Cond. lever-magazine prob. diff.0.10.10.2-0.3-0.3-0.20.50.50.4-0.2-0.5-0.5-0.20.30.50.4-0.3
Pavlov. Cond. response bias0.20.20.4-0.2-0.4-0.10.30.30.5-0.4-0.4-0.4-0.40.50.70.6-0.5
Pavlov. Cond. lever latency0.40.61.40.40.90.4-0.3-0.3-1.01.20.30.31.1-1.2-0.7-0.81.0
Pavlov. Cond. magazine entry latency0.50.71.30.4-0.80.4-0.6-0.61.0-1.10.50.5-1.01.10.70.9-1.2
Pavlov. Cond. change in total contacts0.30.81.0-0.8-0.9-1.00.70.71.0-1.0-0.8-0.8-1.01.00.80.7-0.8
Pavlov. Cond. index score0.30.51.0-0.2-0.9-0.40.20.21.0-1.0-0.3-0.3-0.90.90.80.9-0.9
Pavlov. Cond. latency score0.20.30.6-0.0-0.7-0.1-0.0-0.00.8-0.7-0.1-0.1-0.70.70.60.6-0.7
Pavlov. Cond. lever contacts0.91.32.3-0.9-1.3-1.00.80.81.4-1.5-0.8-0.8-1.51.51.11.1-1.2
Pavlov. Cond. magazine entry number0.60.81.70.01.10.10.20.2-1.31.2-0.0-0.01.2-1.2-0.9-1.01.2
Pavlov. Cond. intertrial magazine entries1.53.25.01.22.10.9-1.0-1.0-2.12.21.11.12.2-2.2-2.1-2.12.2
Pavlov. Cond. lever-magazine prob. diff.0.20.30.6-0.0-0.7-0.2-0.0-0.00.8-0.8-0.2-0.2-0.70.70.60.7-0.8
Pavlov. Cond. response bias1.31.83.7-0.5-1.5-0.60.40.41.7-1.9-0.4-0.4-1.91.91.41.5-1.8
Time in closed arm before self-admin0.61.12.3-1.4-0.8-1.21.51.50.7-0.2-1.5-1.5-0.20.30.90.7-0.4
Time in closed arm after self-admin1.01.21.7-1.1-1.2-0.71.01.01.3-1.0-1.0-1.0-1.01.01.31.3-1.2
Time in open arm before self-admin0.81.01.30.71.00.7-0.9-0.9-1.11.21.01.01.1-1.1-1.1-1.11.0
Time in open arm after self-admin0.00.10.10.2-0.20.2-0.1-0.10.2-0.30.40.4-0.30.30.10.1-0.2
Bone: periosteal estimation0.00.10.20.2-0.3-0.1-0.1-0.10.2-0.1-0.4-0.4-0.10.10.50.5-0.3
Bone: periosteal perimeter0.10.30.7-0.5-0.3-0.80.60.60.2-0.1-0.8-0.8-0.30.30.50.3-0.1
Bone: post-yield work0.10.30.80.90.10.8-0.7-0.70.0-0.10.70.7-0.00.00.20.3-0.4
Progressive ratio test 1 active lever presses0.50.91.71.11.1-0.2-0.8-0.8-1.21.3-0.1-0.11.3-1.3-0.8-0.91.1
Progressive ratio test 1 breakpoint0.50.81.51.01.1-0.4-0.6-0.6-1.21.2-0.2-0.21.2-1.2-0.7-0.91.0
Progressive ratio test 1 inactive lever presses0.20.52.31.50.1-0.2-1.3-1.3-0.20.5-0.0-0.00.4-0.50.30.4-0.1
Progressive ratio test 2 active lever presses0.10.20.40.30.50.1-0.4-0.4-0.40.40.50.50.5-0.5-0.6-0.60.4
Progressive ratio test 2 breakpoint0.20.30.50.40.60.1-0.4-0.4-0.50.50.60.60.6-0.5-0.7-0.70.5
Progressive ratio test 2 inactive lever presses0.10.20.90.9-0.1-0.0-0.9-0.90.3-0.10.30.3-0.10.10.40.4-0.4
Incentive Sensitization - Responses0.10.30.6-0.7-0.30.30.30.30.7-0.60.70.7-0.60.6-0.00.1-0.5
Incentive Sensitization - Breakpoint0.10.30.7-0.6-0.30.40.20.20.6-0.50.80.8-0.50.5-0.10.1-0.4
Sum of active levers in priming session hrs 5-62.72.55.4-2.2-1.2-2.02.32.30.9-1.1-2.0-2.0-1.21.11.00.8-0.7
Progressive ratio0.82.44.70.22.00.8-0.2-0.2-2.02.00.60.62.0-2.2-1.9-2.02.1
Food seeking constrained by brief footshock0.10.10.20.00.30.4-0.2-0.2-0.00.10.50.50.1-0.2-0.4-0.40.3
Seeking ratio, punishment vs. effort0.40.91.80.2-1.2-0.2-0.3-0.31.3-1.1-0.1-0.1-1.11.31.11.2-1.3
Retroperitoneal fat weight0.62.67.12.71.71.1-2.3-2.3-1.71.60.90.91.5-1.4-1.0-1.11.3
Reaction time number correct0.51.92.71.41.51.7-1.3-1.3-1.51.41.21.21.3-1.2-1.4-1.41.3
Reaction time mean minus median0.42.33.9-2.0-1.4-1.41.81.81.3-1.7-1.2-1.2-1.71.61.31.2-1.3
Reaction time mean minus median AUC0.32.03.0-1.7-1.3-1.21.61.61.3-1.7-1.1-1.1-1.61.71.11.1-1.2
Reaction time num false alarms1.32.23.91.91.62.0-1.5-1.5-1.61.41.31.31.3-1.4-1.4-1.41.3
Reaction time num false alarms AUC1.53.45.52.41.92.3-2.0-2.0-1.81.71.61.61.6-1.7-1.7-1.61.6
Reaction time trials correct on left0.51.92.71.41.51.7-1.3-1.3-1.51.41.21.21.3-1.2-1.4-1.41.3
Reaction time trials on left0.51.72.51.41.51.6-1.2-1.2-1.41.31.21.21.2-1.1-1.4-1.31.2
Reaction time mean1.84.15.6-2.3-2.1-2.42.22.21.7-2.0-2.2-2.2-1.81.91.91.7-1.6
Reaction time mean AUC1.22.94.3-1.9-1.7-2.11.91.91.3-1.7-2.0-2.0-1.51.51.51.4-1.3
Median of all reaction times2.33.55.8-2.1-2.0-2.42.02.01.5-1.7-2.2-2.2-1.51.61.81.6-1.5
Reaction time omissions0.91.52.8-1.5-1.5-1.01.11.11.7-1.4-0.7-0.7-1.31.31.11.1-1.2
Reaction time false alarm rate0.70.91.81.30.91.4-1.1-1.1-0.90.80.90.90.7-0.8-0.8-0.80.7
Reaction time premature initiation rate0.10.20.40.1-0.4-0.20.00.00.6-0.6-0.1-0.1-0.50.60.60.6-0.5
Reaction time premature initiations0.00.10.60.80.30.5-0.6-0.6-0.00.10.40.40.20.0-0.1-0.10.1
Std. dev. reaction times1.23.96.7-2.6-2.0-1.82.22.21.8-2.3-1.5-1.5-2.22.21.61.6-1.7
Reaction time trials completed0.51.72.51.41.51.6-1.2-1.2-1.41.31.21.21.2-1.1-1.4-1.31.2
Reaction time trials AUC0.51.62.31.31.41.5-1.1-1.1-1.41.31.11.11.2-1.1-1.3-1.31.2
Run reversals in cocaine runway, females0.50.60.80.80.80.7-0.6-0.6-0.70.60.90.90.7-0.7-0.8-0.80.7
Run reversals in cocaine runway, males0.20.20.50.20.3-0.3-0.2-0.2-0.30.7-0.4-0.40.7-0.6-0.2-0.30.5
Latency to leave start box in cocaine runway2.02.86.62.61.61.9-2.3-2.3-1.31.41.71.71.5-1.5-0.9-0.70.8
Latency to leave start box in cocaine runway, F0.70.92.31.50.51.2-1.5-1.5-0.30.31.31.30.3-0.4-0.10.1-0.1
Latency to leave start box in cocaine runway, M4.44.25.82.42.32.3-1.9-1.9-2.12.21.71.72.4-2.3-1.8-1.71.8
Std. dev. time between licks in bursts0.50.91.40.61.10.9-0.5-0.5-1.21.00.40.41.2-1.1-1.1-1.21.2
Total sessions with >9 infusions0.91.12.11.41.00.2-1.2-1.2-1.11.40.10.11.4-1.4-0.8-0.91.2
Short access day 1 total inactive lever presses0.51.03.51.80.50.6-1.9-1.9-0.30.61.01.00.7-0.5-0.4-0.30.3
Short access day 10 total inactive lever presses0.10.31.1-0.1-1.0-0.3-0.1-0.11.0-0.50.10.1-0.60.60.70.8-0.8
Short access day 1 total infusions0.61.21.91.31.00.6-1.4-1.4-0.91.30.60.61.4-1.3-1.0-1.01.1
Short access day 10 total infusions0.50.92.1-0.10.5-1.40.30.3-0.91.0-1.4-1.41.0-0.9-0.5-0.91.1
Short access total infusions0.50.81.80.40.7-0.6-0.4-0.4-0.91.3-0.7-0.71.4-1.3-0.6-0.91.1
Short access day 1 locomotion1.11.93.31.81.41.1-1.7-1.7-1.31.50.90.91.5-1.5-1.2-1.21.2
Short access day 10 total locomotion0.00.00.10.1-0.1-0.30.10.1-0.00.0-0.0-0.00.00.0-0.0-0.10.1
Short access total locomotion1.21.93.31.81.41.1-1.5-1.5-1.41.41.11.11.4-1.3-1.3-1.31.3
One hour access (0.3 mA shock)1.82.17.4-1.5-0.5-2.71.81.8-0.10.4-2.4-2.40.4-0.40.50.00.4
Compulsive drug intake0.10.20.50.20.30.5-0.4-0.4-0.1-0.20.70.7-0.20.3-0.4-0.3-0.1
One hour access (shock baseline)0.51.44.9-1.1-0.8-2.21.31.30.40.0-2.1-2.1-0.0-0.10.60.20.1
Social response proportion0.30.40.8-0.7-0.5-0.80.90.90.6-0.1-0.6-0.60.20.10.80.7-0.5
Social responses1.11.52.3-1.1-1.2-1.51.41.41.2-0.9-1.5-1.5-0.81.01.31.2-1.0
Social time4.06.28.2-2.5-2.7-2.22.52.52.7-2.4-2.3-2.3-2.32.42.92.7-2.6
Soleus weight1.33.85.92.02.32.4-2.1-2.1-1.91.62.12.11.6-1.5-1.9-1.81.5
Bone: stiffness0.61.23.41.90.61.5-1.7-1.7-0.40.61.21.20.7-0.7-0.10.10.0
Tibialis anterior weight3.110.613.62.93.43.5-3.2-3.2-3.02.93.73.72.9-2.8-3.7-3.53.0
Time to tail flick, vehicle, before self-admin0.40.41.5-0.6-0.3-1.20.80.80.2-0.1-1.1-1.1-0.20.10.60.4-0.2
Time to tail flick, vehicle, after self-admin0.20.41.1-1.1-0.6-0.40.90.90.5-0.4-0.5-0.5-0.40.30.50.5-0.4
Time to tail flick, test, before self-admin2.02.34.30.62.01.6-1.1-1.1-1.71.01.71.71.0-1.0-2.1-2.01.6
Time to tail flick, test, after self-admin2.52.65.92.41.70.9-2.0-2.0-1.81.80.40.41.8-1.8-1.2-1.31.6
Delta time to tail flick, vehicle, before/after SA0.10.10.3-0.10.00.6-0.1-0.1-0.0-0.00.40.40.0-0.1-0.2-0.1-0.0
Delta time to tail flick, test, before/after SA0.40.51.51.0-0.5-1.0-0.4-0.40.00.3-1.2-1.20.3-0.30.90.8-0.3
Tibia length0.20.61.70.0-0.8-0.30.10.10.9-0.8-0.4-0.4-0.80.81.31.3-1.1
Ambulatory time before self-admin0.41.21.9-0.8-1.1-0.71.01.00.8-1.3-1.0-1.0-1.31.41.31.3-1.2
Ambulatory time after self-admin1.42.24.0-0.7-1.9-0.40.70.72.0-1.8-0.5-0.5-1.81.81.82.0-2.0
Bone: tissue strength0.20.20.40.60.60.1-0.5-0.5-0.70.40.30.30.3-0.3-0.3-0.30.3
Total heroin consumption1.72.06.6-1.5-0.5-2.61.91.90.10.3-2.3-2.30.2-0.20.50.10.4
Bone: trabecular number3.05.68.7-1.4-2.7-1.51.31.32.6-2.8-1.8-1.8-2.92.92.93.0-2.9
Bone: trabecular spacing2.13.14.41.31.91.7-1.1-1.1-1.72.11.71.72.1-2.1-1.9-1.81.9
Bone: trabecular thickness5.06.99.0-2.2-2.9-2.42.12.12.6-3.0-2.5-2.5-3.03.02.92.8-2.8
Bone: trabecular tissue density0.20.31.20.3-0.20.7-0.5-0.50.5-0.51.11.1-0.40.4-0.00.2-0.5
Water consumed over 24 hours0.10.10.3-0.30.1-0.30.50.5-0.30.3-0.5-0.50.4-0.30.0-0.10.2
Number of responses in last shaping day0.00.10.20.2-0.5-0.2-0.2-0.20.4-0.1-0.1-0.10.10.20.30.3-0.2