Hub : Genes

Narf

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Narf 0.54 0.07 0.0e+00 0.39 0.41 0.39 0.42 3.4e-22 4.0e-23 5.4e-22 2.8e-24
2 Eye gene expression Narf 0.3 0.16 6.7e-03 0.02 0.06 0.04 0.02 1.8e-01 3.8e-02 9.5e-02 1.4e-01
3 Brain mRNA stability Narf 0.04 0.03 6.0e-04 0.02 0.03 0.03 0.03 1.0e-02 5.2e-04 1.6e-03 9.2e-04
4 pVTA gene expression Narf 0.24 0.1 9.9e-13 0.14 0.16 0.17 0.17 2.9e-11 5.8e-13 2.3e-13 7.1e-14
5 Adipose gene expression Narf 0.04 0.03 9.5e-05 0.01 0.03 0.03 0.02 1.2e-02 3.0e-04 7.2e-04 3.1e-03
6 LHb gene expression Narf 0.34 0.13 4.6e-05 0.17 0.12 0.1 0.14 9.6e-05 9.6e-04 2.1e-03 3.2e-04
7 PL gene expression Narf 0.52 0.1 0.0e+00 0.39 0.41 0.41 0.41 2.1e-45 1.9e-48 1.6e-48 9.2e-49
8 Brain gene expression Narf 0.59 0.08 0.0e+00 0.48 0.48 0.49 0.48 2.5e-50 1.4e-49 1.6e-51 5.6e-51
9 IL gene expression Narf 0.52 0.13 7.5e-11 0.41 0.33 0.34 0.32 4.5e-11 1.1e-08 6.9e-09 1.5e-08
10 NAcc gene expression Narf 0.45 0.04 0.0e+00 0.51 0.51 0.52 0.53 2.1e-90 9.1e-90 8.3e-94 1.3e-94
11 IC gene expression Narf 0.48 0.12 2.8e-15 0.34 0.3 0.33 0.32 8.1e-15 4.0e-13 2.2e-14 5.2e-14
12 Liver gene expression Narf 0.12 0.06 4.2e-09 0.07 0.08 0.07 0.07 1.0e-08 2.1e-09 3.4e-08 1.7e-08
13 OFC gene expression Narf 0.49 0.14 1.8e-09 0.26 0.28 0.24 0.27 8.5e-07 2.8e-07 1.6e-06 4.6e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.10.10.40.6-0.3-0.4-0.20.60.00.1-0.00.5-0.00.0-0.20.0
Area under the delay curve1.72.02.7-1.7-0.61.5-1.2-1.4-1.4-1.6-1.5-1.5-1.5-1.5-1.2-1.2
BMI with tail0.20.82.51.60.7-0.91.20.70.80.80.91.20.80.7-0.4-0.3
BMI without tail0.51.46.11.20.1-2.10.42.51.01.10.80.90.80.70.80.6
Body weight1.14.88.22.61.9-2.92.22.82.22.32.02.22.02.01.51.4
Weight adjusted by age1.72.64.12.01.1-1.91.31.81.71.91.61.91.61.50.91.3
Bone surface0.10.30.60.60.0-0.70.10.80.50.50.40.40.50.50.30.7
Bone volume0.10.20.60.7-0.1-0.6-0.00.80.40.40.30.60.40.40.30.5
Breakpoint value in progressive ratio session1.21.53.1-0.01.7-0.41.50.61.31.11.30.11.51.51.71.2
Number of licking bursts0.10.20.7-0.1-0.80.0-0.70.1-0.4-0.4-0.6-0.2-0.5-0.5-0.4-0.4
Context. condit. distance diff. score0.70.92.8-0.6-1.70.1-1.30.4-1.0-0.8-1.1-0.7-0.9-1.0-0.6-0.8
Locomotion velocity, session 10.40.41.30.31.00.61.0-1.20.60.40.60.60.50.40.10.2
Locomotion distance, session 12.53.26.4-1.0-1.31.8-1.3-2.0-2.0-1.9-1.7-1.1-1.9-1.9-2.5-2.2
Locomotion velocity, session 21.92.25.2-1.8-0.42.1-0.7-2.3-1.2-1.4-1.1-1.7-1.3-1.3-1.5-1.3
Locomotion distance, session 21.01.42.9-1.0-0.90.8-0.9-0.8-1.4-1.3-1.2-1.1-1.3-1.3-1.7-1.5
Locomotion velocity, session 30.80.92.3-1.40.41.40.1-1.5-0.6-0.8-0.4-1.4-0.6-0.7-0.9-0.6
Locomotion distance, session 32.52.75.1-2.0-0.42.2-0.7-2.2-1.5-1.7-1.3-1.9-1.5-1.5-1.7-1.6
Stereotopy head waving bouts, day 30.20.20.60.30.60.20.8-0.70.40.30.50.20.30.4-0.4-0.0
Stereotopy head waving duration, day 30.10.10.50.10.20.30.5-0.70.10.10.3-0.00.10.2-0.7-0.3
Locomotion velocity, session 71.01.11.3-1.1-0.91.1-1.1-1.0-1.1-1.1-1.0-1.0-1.1-1.1-0.9-0.8
Locomotion distance, session 74.55.77.3-2.7-2.22.5-2.2-2.2-2.4-2.4-2.3-2.6-2.4-2.4-2.1-2.4
Stereotopy head waving bouts, day 70.30.30.60.70.4-0.80.40.50.60.70.50.50.60.60.10.4
Stereotopy head waving duration, day 70.20.30.60.70.4-0.70.30.60.50.60.40.40.50.5-0.00.4
Locomotion velocity, session 81.51.83.7-0.9-1.11.0-1.0-0.7-1.5-1.5-1.4-1.0-1.5-1.5-1.9-1.6
Locomotion distance, session 82.53.65.8-1.5-2.40.7-2.0-0.2-2.2-1.9-2.1-1.7-2.1-2.1-2.2-2.2
Degree of sensitization distance0.20.20.9-0.1-0.9-0.5-0.60.8-0.10.1-0.20.0-0.0-0.00.40.0
Degree of sensitization stereotypy0.10.10.40.50.2-0.60.10.60.30.40.10.20.30.20.00.2
Conditioned locomotion0.81.04.71.1-0.4-1.80.12.20.40.70.40.90.70.70.80.7
Cocaine response after cond. corrected0.10.10.5-0.00.70.20.4-0.20.10.00.20.10.10.10.50.2
Cocaine response after cond. not corrected0.20.30.6-0.60.30.8-0.1-0.8-0.5-0.6-0.4-0.5-0.5-0.6-0.1-0.3
Cocaine response before conditioning1.92.32.9-1.5-1.31.3-1.4-1.3-1.7-1.6-1.5-1.6-1.6-1.6-1.6-1.5
Saline control response0.50.73.50.4-0.1-1.30.01.90.40.50.30.40.50.51.00.8
Bone: connectivity density0.30.41.1-0.2-1.10.2-0.90.1-0.7-0.6-0.7-0.4-0.6-0.6-0.8-0.6
Bone: cortical apparent density1.21.74.1-1.7-0.51.9-0.6-2.0-1.1-1.2-0.9-1.4-1.1-1.1-1.1-1.2
Bone: cortical area4.26.49.83.12.7-3.03.12.62.42.52.62.72.42.40.61.6
Bone: cortical porosity3.33.65.51.62.3-1.42.30.71.92.02.21.72.02.01.92.0
Bone: cortical porosity3.63.95.21.72.2-1.62.31.12.02.12.21.92.12.11.92.0
Bone: cortical thickness5.69.216.83.63.6-3.24.12.52.83.03.33.33.03.01.01.9
Bone: cortical thickness1.92.24.32.01.7-1.42.11.01.31.51.62.01.41.40.40.7
Bone: cortical tissue density1.31.74.5-1.7-0.62.0-0.7-2.1-1.1-1.2-1.0-1.4-1.1-1.1-1.0-1.2
Condit. Reinf. active minus inactive responses1.21.43.11.50.5-1.60.91.81.01.11.01.31.01.10.90.9
Condit. Reinf. active-inactive response ratio0.50.51.21.00.6-0.90.51.10.50.60.60.90.50.60.10.5
Condit. Reinf. active responses1.92.35.81.70.4-2.21.02.41.41.61.21.61.41.41.51.2
Condit. Reinf. inactive responses0.60.71.60.7-0.1-1.10.41.20.80.90.50.70.80.71.30.7
Incentive salience index mean0.60.82.31.20.2-1.30.41.50.70.80.61.10.70.80.70.6
Condit. Reinf. lever presses0.30.41.0-0.3-1.00.4-1.0-0.2-0.7-0.6-0.9-0.3-0.7-0.7-0.3-0.7
Condit. Reinf. active minus inactive responses0.40.51.61.30.6-1.00.61.00.40.50.41.00.30.4-0.30.2
Condit. Reinf. active-inactive response ratio2.63.15.42.31.5-2.01.71.81.71.81.72.01.61.71.11.4
Condit. Reinf. active responses0.10.10.40.40.0-0.2-0.10.4-0.3-0.2-0.30.2-0.3-0.3-0.6-0.3
Condit. Reinf. inactive responses1.21.51.9-1.2-0.81.3-1.1-1.0-1.3-1.4-1.3-1.3-1.4-1.4-1.3-1.2
Condit. Reinf. lever presses0.10.20.4-0.4-0.6-0.1-0.40.4-0.6-0.4-0.4-0.5-0.5-0.4-0.3-0.4
Condit. Reinf. lever reinforcers received0.10.10.50.3-0.2-0.2-0.30.4-0.4-0.3-0.40.0-0.4-0.4-0.7-0.4
Conditioned reinforcement - actives0.50.92.0-1.4-0.70.7-0.9-0.7-1.1-1.0-1.0-1.3-1.1-1.0-0.5-0.8
Conditioned reinforcement - inactives0.20.20.7-0.80.2-0.10.50.40.40.40.3-0.70.50.50.80.2
Conditioned locomotion0.40.52.2-1.5-0.40.3-0.4-0.2-0.5-0.5-0.5-1.5-0.4-0.4-0.6-0.4
Patch foraging indifference point 0 sec0.00.00.1-0.1-0.1-0.0-0.30.3-0.2-0.2-0.2-0.2-0.2-0.10.20.2
Patch foraging indifference point AUC0.00.00.20.1-0.4-0.2-0.10.2-0.00.1-0.10.20.00.10.3-0.0
Delay disc. indifference point, 0s delay0.10.10.40.20.10.1-0.1-0.2-0.3-0.3-0.30.3-0.3-0.4-0.6-0.3
Delay disc. indifference point, 16s delay4.04.45.5-2.3-1.71.9-2.0-1.5-2.2-2.3-2.4-2.2-2.3-2.2-1.8-2.0
Delay disc. indifference point, 2s delay0.10.20.5-0.70.10.6-0.1-0.7-0.1-0.3-0.2-0.5-0.2-0.2-0.3-0.3
Delay disc. indifference point, 24s delay1.41.65.2-1.50.12.0-0.3-2.3-0.9-1.2-0.8-1.6-0.8-0.8-1.2-1.0
Delay disc. indifference point, 4s delay0.30.30.6-0.7-0.00.6-0.4-0.4-0.6-0.8-0.7-0.7-0.6-0.7-0.6-0.4
Delay disc. indifference point, 8s delay0.30.40.8-0.50.30.8-0.3-0.8-0.7-0.9-0.7-0.4-0.7-0.7-0.3-0.3
Indifference point function ln k0.81.33.2-0.6-0.51.2-0.8-1.2-1.3-1.4-1.2-0.7-1.3-1.3-1.8-1.2
Indifference point function log k0.81.33.2-0.6-0.51.2-0.8-1.2-1.3-1.4-1.2-0.7-1.3-1.3-1.8-1.2
Patch foraging total patch changes 0 sec0.00.10.1-0.2-0.1-0.0-0.40.3-0.3-0.3-0.3-0.3-0.3-0.30.10.0
Patch foraging total patch changes 12 sec0.30.41.40.40.2-0.40.50.40.70.70.60.50.70.71.20.6
Patch foraging total patch changes 18 sec0.30.50.8-0.9-0.80.4-0.8-0.1-0.6-0.7-0.8-0.9-0.7-0.7-0.6-0.7
Patch foraging total patch changes 24 sec0.10.30.90.20.2-0.60.40.90.50.50.40.20.50.50.60.4
Patch foraging total patch changes 6 sec0.30.50.90.70.4-0.90.40.80.60.70.60.70.60.71.00.8
Patch foraging time to switch 0 sec0.10.20.7-0.4-0.40.7-0.4-0.9-0.4-0.4-0.4-0.3-0.3-0.3-0.4-0.4
Patch foraging water rate 0 sec0.20.42.7-0.20.2-1.00.21.60.30.30.1-0.30.30.31.10.5
Patch foraging water rate 12 sec0.10.10.5-0.2-0.30.0-0.00.3-0.3-0.2-0.3-0.2-0.4-0.3-0.4-0.7
Patch foraging water rate 18 sec0.10.20.6-0.2-0.5-0.2-0.30.5-0.3-0.3-0.4-0.4-0.5-0.4-0.8-0.7
Patch foraging water rate 24 sec0.20.21.6-0.4-0.4-0.60.11.30.10.0-0.0-0.7-0.0-0.0-0.3-0.5
Patch foraging water rate 6 sec0.20.20.7-0.70.10.40.2-0.2-0.5-0.4-0.2-0.8-0.4-0.4-0.5-0.9
Seeking ratio, delayed vs. immediate footshock0.70.81.91.40.2-1.10.51.30.60.60.61.40.80.80.70.6
Distance traveled before self-admin0.91.11.6-0.01.3-1.01.11.11.31.11.2-0.31.21.21.11.3
Distance traveled after self-admin0.40.52.0-1.4-0.8-0.3-0.90.7-0.1-0.2-0.5-1.4-0.2-0.20.80.3
Extensor digitorum longus weight0.20.71.70.4-1.3-0.1-0.90.1-0.8-0.6-0.90.1-0.9-0.9-1.1-1.0
Bone: elastic displacement1.41.62.21.01.1-1.41.51.21.21.41.51.11.41.50.91.1
Bone: elastic work10.213.216.24.03.6-3.83.93.23.73.83.84.03.73.72.73.3
Bone: endosteal estimation0.40.82.0-0.8-1.20.5-1.4-0.2-0.7-0.7-1.0-1.0-0.9-0.9-0.8-0.7
Bone: endosteal perimeter0.30.71.61.10.4-1.10.31.30.90.80.70.80.80.80.51.0
Epididymis fat weight0.10.31.90.4-0.2-1.10.21.40.10.40.10.20.20.20.70.1
Delta time in closed arm before/after self-admin2.11.93.5-0.2-1.50.8-1.9-0.4-1.8-1.6-1.8-0.3-1.8-1.8-0.9-1.2
Delta time in open arm before/after self-admin0.30.30.6-0.80.10.40.5-0.40.60.50.6-0.60.60.70.40.1
Diff in mean of infusions in LGA sessions0.10.10.70.30.4-0.1-0.20.30.20.00.00.30.20.10.90.8
Delay discount exponential model param1.71.93.21.80.4-1.71.01.61.41.61.41.61.41.41.11.1
Extinction: sum of active levers before priming0.80.92.10.90.80.41.5-0.90.90.81.21.21.01.1-0.1-0.0
Active lever presses in extinction session 61.61.65.2-0.02.30.42.1-0.81.41.01.50.11.41.30.80.8
Bone: final force3.55.69.42.72.3-3.12.62.82.32.52.42.32.22.30.91.5
Bone: final moment4.87.711.83.22.7-3.43.03.12.72.92.82.82.72.71.22.0
Food consumed during 24 hour testing period0.20.20.60.8-0.2-0.6-0.20.80.10.20.10.60.20.20.60.5
Glucose1.52.38.40.32.91.32.2-2.41.00.71.60.71.11.20.61.0
Heart weight2.13.35.61.81.7-1.72.41.12.12.12.11.72.12.11.01.1
Delay discount hyperbolic model param1.41.52.61.60.3-1.60.81.51.21.41.21.41.21.21.01.0
Intermittent access intake day 1-15 change0.40.94.1-1.10.7-0.40.31.00.70.60.5-0.80.70.62.01.3
Intermittent access intake escalation0.30.73.1-1.10.6-0.30.20.90.60.50.4-0.90.60.51.81.1
Intermittent access intake escalation 22.42.76.8-0.51.6-1.11.51.41.91.71.7-0.21.91.92.62.0
Intermitt. access day 1 inactive lever presses0.10.52.7-0.8-0.5-0.9-0.51.6-0.1-0.1-0.2-0.8-0.1-0.01.20.3
Intermitt. access day 15 inactive lever presses0.10.20.7-0.6-0.7-0.4-0.40.90.00.1-0.1-0.70.1-0.0-0.1-0.1
Intermitt. access escalation Index0.40.51.4-0.5-0.90.0-1.20.6-0.8-0.8-0.8-0.6-0.8-0.80.2-0.1
Intermittent access day 1 total infusions0.00.00.20.20.1-0.40.10.1-0.10.10.10.30.10.1-0.1-0.0
Intermittent access day 15 total infusions0.10.20.8-0.30.2-0.50.10.70.30.40.2-0.20.40.40.90.6
Intermittent access terminal intake (last 3 days)0.40.51.7-0.20.4-0.70.31.00.50.70.5-0.00.70.71.30.9
Intermittent access total infusions0.10.10.2-0.3-0.0-0.3-0.30.4-0.3-0.1-0.3-0.2-0.2-0.10.40.2
Intermittent access day 1 locomotion0.50.61.4-1.2-0.20.5-0.6-0.3-0.9-0.9-0.8-1.1-0.8-0.8-0.4-0.6
Intermittent access day 15 total locomotion0.10.20.5-0.20.5-0.50.50.70.40.40.3-0.20.40.50.70.6
Intermittent access total locomotion0.10.20.8-0.90.20.0-0.10.2-0.3-0.3-0.3-0.9-0.2-0.20.30.0
Intermittent access standard deviation0.20.41.6-0.81.30.50.5-0.60.10.20.2-0.50.30.20.90.6
Left kidney weight0.20.92.71.01.4-0.61.60.11.11.01.10.81.01.0-0.20.3
Right kidney weight0.20.82.81.01.2-0.31.7-0.20.90.91.00.70.80.8-0.5-0.1
Cocaine induced anxiety3.04.38.81.53.0-1.22.51.02.42.02.41.52.22.12.22.0
Post-drug Anxiety1.81.96.00.62.5-0.31.90.11.71.21.60.71.41.31.51.3
Baseline Anxiety0.81.01.4-0.9-0.81.2-1.0-1.1-1.1-1.1-1.0-0.7-1.0-1.0-0.9-0.8
Tail length0.93.712.71.20.6-3.00.53.61.61.71.21.11.41.32.72.1
Length with tail0.94.06.31.62.2-2.31.82.41.91.91.71.61.81.82.52.2
Length without tail1.23.89.31.93.0-1.22.80.62.01.82.11.81.91.91.41.6
Times rat made contact with spout3.03.46.21.71.0-1.81.31.61.91.91.91.91.91.92.52.3
Lifetime Intake0.10.10.3-0.5-0.10.2-0.4-0.1-0.5-0.4-0.5-0.4-0.3-0.40.3-0.1
Liver weight, left0.40.72.0-0.90.11.1-0.3-1.4-0.8-0.9-0.7-0.8-0.9-0.9-0.4-0.7
Liver weight, right0.30.52.40.7-0.1-1.30.31.60.60.70.40.30.50.50.50.4
Locomotor activity0.30.51.3-1.0-0.31.0-0.2-1.1-0.5-0.6-0.4-1.0-0.4-0.4-0.6-0.6
Locomotor testing distance1.32.43.2-1.1-1.11.7-1.3-1.8-1.7-1.7-1.6-1.1-1.7-1.7-1.8-1.5
Locomotor testing rearing0.71.42.3-1.5-1.31.3-1.2-1.0-1.3-1.3-1.2-1.3-1.2-1.2-0.6-1.0
Locomotion in novel chamber0.60.81.60.4-0.70.5-1.0-0.6-1.0-0.9-1.20.3-1.1-1.2-1.3-0.8
Locomotion in novel chamber post-restriction1.42.25.91.70.5-2.00.52.41.11.30.81.71.21.21.91.7
Fecal boli incidents, locomotor time 10.30.40.8-0.4-0.90.6-0.6-0.8-0.6-0.5-0.5-0.3-0.5-0.4-0.9-0.8
Change in fecal boli incidents, locomotor task0.30.31.0-0.50.90.80.3-0.90.2-0.10.1-0.10.2-0.01.00.5
Time >=10cm from walls, locomotor time 10.50.51.2-0.6-1.1-0.1-1.10.9-0.7-0.7-0.9-0.9-0.6-0.7-0.3-0.4
Bouts of movement, locomotor time 10.30.31.60.2-0.10.80.0-1.3-0.4-0.4-0.20.3-0.3-0.4-0.9-0.5
Total resting periods, locomotor time 10.30.31.90.1-0.00.90.0-1.4-0.4-0.4-0.20.1-0.4-0.4-0.8-0.5
Rest time, locomotor task time 10.20.20.40.00.50.10.5-0.50.60.50.70.10.50.50.40.4
Distance moved, locomotor task time 10.30.40.8-0.8-0.20.4-0.80.3-0.8-0.8-0.9-0.8-0.7-0.70.5-0.2
Vertical activity count, locomotor time 10.10.20.5-0.3-0.4-0.1-0.50.7-0.4-0.4-0.6-0.5-0.4-0.40.1-0.2
Time >=10cm from walls, locomotor time 20.20.20.70.80.3-0.70.50.40.40.40.40.60.40.3-0.60.1
Bouts of movement, locomotor time 21.11.83.2-0.7-0.81.3-1.3-1.2-1.8-1.7-1.6-0.7-1.7-1.8-0.9-1.1
Total resting periods, locomotor time 21.22.13.8-0.8-1.11.1-1.6-1.0-2.0-1.8-1.7-0.8-1.8-1.9-1.1-1.2
Rest time, locomotor task time 20.20.20.9-0.0-0.50.1-1.0-0.1-0.6-0.5-0.6-0.1-0.7-0.70.10.1
Distance moved, locomotor task time 20.10.10.2-0.40.20.30.1-0.2-0.2-0.2-0.2-0.4-0.1-0.2-0.2-0.4
Vertical activity count, locomotor time 20.20.20.7-0.6-0.20.30.1-0.2-0.3-0.3-0.2-0.7-0.2-0.3-0.8-0.9
Light reinforcement 10.30.71.91.3-1.2-0.8-0.91.1-0.3-0.1-0.51.4-0.4-0.40.2-0.1
Light reinforcement 20.40.61.81.3-0.3-1.2-0.01.40.30.50.31.30.30.40.70.4
Bone: marrow area0.40.82.0-0.8-1.20.5-1.4-0.2-0.7-0.7-1.0-1.0-0.9-0.9-0.8-0.8
Bone: maximum diameter0.91.62.71.61.3-1.51.41.41.21.21.31.31.21.20.10.8
Bone: maximum force3.15.59.82.92.2-3.12.52.92.32.52.32.42.12.10.81.4
Bone: maximum moment4.37.612.13.42.6-3.52.93.22.72.92.72.92.62.61.21.9
Mean time between licks in bursts0.71.73.0-1.3-0.81.7-1.1-1.6-1.3-1.4-1.3-1.3-1.3-1.3-1.1-1.3
Mean num. licks in bursts1.11.72.61.01.1-1.11.30.91.31.31.51.21.41.41.61.6
Cd content in liver1.31.42.2-1.5-1.41.0-1.3-0.7-1.0-1.2-1.2-1.5-1.2-1.2-0.9-1.3
Co content in liver0.00.00.10.1-0.20.0-0.10.10.20.20.20.10.20.20.20.2
Cu content in liver1.01.22.10.81.1-1.10.91.11.11.11.10.81.11.11.41.4
Fe content in liver1.41.72.2-1.5-1.01.2-1.4-1.0-1.4-1.4-1.4-1.5-1.4-1.5-1.1-1.1
K content in liver1.00.92.4-0.8-1.60.1-1.50.7-1.0-0.9-1.1-0.8-1.0-1.0-0.0-0.6
Mg content in liver2.32.35.6-1.7-2.40.8-2.10.1-1.6-1.5-1.7-1.6-1.5-1.5-0.6-1.4
Mn content in liver0.00.00.1-0.3-0.0-0.10.10.10.00.00.1-0.30.00.00.0-0.2
Na content in liver0.90.91.3-1.1-1.00.8-1.1-0.4-1.1-1.1-1.0-1.1-1.0-1.0-0.6-0.8
Rb content in liver0.30.32.20.3-0.7-1.0-0.31.50.30.40.20.10.30.30.00.0
Se content in liver0.10.10.4-0.4-0.5-0.2-0.30.60.1-0.0-0.1-0.30.0-0.00.60.2
Sr content in liver0.80.71.60.71.3-0.41.0-0.00.80.70.90.90.90.90.81.0
Zn content in liver0.30.41.60.3-0.4-0.9-0.31.30.40.50.20.30.40.41.00.5
Bone: minimum diameter2.13.85.72.41.6-2.41.82.42.02.11.92.11.91.91.11.7
Time in familiar zone, hab. session 10.40.40.70.40.7-0.30.90.10.80.80.80.40.70.70.60.5
Time in novel zone, hab. session 10.10.10.3-0.1-0.50.2-0.5-0.1-0.5-0.5-0.50.0-0.5-0.4-0.3-0.3
Total zone transitions, hab. session 10.20.30.7-0.4-0.30.5-0.0-0.7-0.5-0.5-0.3-0.4-0.5-0.4-0.8-0.8
Total locomotion distance, hab. session 10.10.10.50.2-0.4-0.20.1-0.1-0.2-0.0-0.10.1-0.1-0.1-0.7-0.6
Locomotion velocity, hab. session 10.10.10.50.0-0.5-0.20.0-0.1-0.2-0.0-0.1-0.1-0.2-0.1-0.7-0.6
Time in familiar zone, hab. session 20.20.20.4-0.5-0.60.7-0.5-0.7-0.2-0.4-0.5-0.4-0.4-0.5-0.2-0.6
Time in novel zone, hab. session 20.00.00.2-0.00.10.00.1-0.0-0.3-0.2-0.1-0.1-0.2-0.1-0.5-0.2
Total zone transitions, hab. session 21.31.62.8-0.3-1.70.5-1.3-0.5-1.6-1.3-1.4-0.4-1.5-1.4-1.7-1.6
Total locomotion distance, hab. session 20.70.92.60.3-1.6-0.2-1.10.3-1.0-0.7-1.00.2-1.0-1.0-1.1-1.2
Locomotion velocity, hab. session 20.50.62.00.4-1.4-0.4-0.80.5-0.8-0.5-0.80.3-0.8-0.8-1.0-1.0
Novel to familiar place preference ratio3.53.84.82.22.0-2.11.91.91.81.91.92.21.91.71.82.0
Novelty place preference3.63.95.32.32.0-2.11.91.91.91.91.92.31.91.71.82.0
Time in novel zone, NPP test2.83.04.22.11.7-1.91.71.71.61.71.72.11.71.51.61.8
Total zone transitions, NPP test2.53.65.3-1.3-2.31.2-2.1-0.9-2.2-2.0-2.1-1.5-2.1-2.0-2.2-2.2
Total locomotion distance, NPP test1.72.34.9-1.0-2.20.6-1.7-0.3-1.7-1.4-1.6-1.1-1.6-1.6-1.7-1.9
Locomotion velocity, NPP test0.91.23.1-0.6-1.80.2-1.3-0.0-1.3-1.0-1.2-0.7-1.2-1.2-1.3-1.4
Intraocular pressure0.20.21.5-0.3-0.2-0.9-0.11.20.30.40.1-0.30.30.30.40.4
Delta distance traveled before/after self-admin1.01.11.9-1.2-1.40.9-1.3-0.6-1.0-1.0-1.2-0.8-1.1-1.1-0.3-0.8
Delta ambulatory time before/after self-admin2.02.44.0-1.3-2.01.4-2.0-1.2-1.7-1.7-1.8-1.0-1.8-1.7-0.8-1.3
Parametrial fat weight0.10.30.80.5-0.6-0.8-0.40.9-0.00.2-0.10.60.00.00.80.2
Pavlov. Cond. lever latency2.22.84.7-1.9-1.81.5-1.5-1.1-1.6-1.6-1.6-2.2-1.6-1.5-1.9-1.8
Pavlov. Cond. magazine entry latency3.14.05.62.02.1-1.92.01.81.91.91.92.02.01.92.42.2
Pavlov. Cond. change in total contacts1.61.72.71.01.7-0.81.60.41.41.31.41.31.41.41.61.3
Pavlov. Cond. index score3.34.15.72.31.8-2.11.82.01.91.91.82.41.91.92.32.2
Pavlov. Cond. latency score3.24.15.92.31.9-2.01.81.81.91.91.82.41.91.92.32.2
Pavlov. Cond. lever contacts0.91.12.11.31.0-1.10.80.80.91.00.91.40.90.91.31.2
Pavlov. Cond. magazine entry number4.75.97.8-2.3-2.72.2-2.6-1.8-2.5-2.4-2.5-2.4-2.5-2.5-2.8-2.7
Pavlov. Cond. intertrial magazine entries0.10.21.0-0.1-1.0-0.2-0.60.4-0.2-0.1-0.4-0.1-0.3-0.3-0.2-0.5
Pavlov. Cond. lever-magazine prob. diff.3.03.74.72.11.8-2.01.71.91.81.81.72.21.81.82.22.0
Pavlov. Cond. response bias3.34.15.72.02.2-1.82.11.52.02.02.02.22.02.02.42.2
Pavlov. Cond. lever latency0.10.21.0-0.20.80.70.3-1.00.2-0.00.10.10.0-0.10.00.1
Pavlov. Cond. magazine entry latency2.83.44.4-2.1-1.91.9-1.7-1.7-1.9-1.9-1.7-2.0-1.8-1.8-1.5-1.9
Pavlov. Cond. change in total contacts0.40.60.9-0.8-0.90.6-0.7-0.4-0.9-0.9-0.8-0.9-0.8-0.7-0.9-0.8
Pavlov. Cond. index score0.50.71.1-1.0-1.10.6-0.8-0.4-1.0-0.9-0.8-1.0-0.8-0.8-0.6-0.9
Pavlov. Cond. latency score0.60.81.6-1.0-1.30.6-0.9-0.4-1.0-0.9-0.9-1.0-0.9-0.8-0.8-1.0
Pavlov. Cond. lever contacts0.10.20.80.0-0.9-0.5-0.50.8-0.3-0.1-0.2-0.2-0.2-0.1-0.2-0.2
Pavlov. Cond. magazine entry number2.43.04.22.11.6-1.71.71.41.91.91.71.91.81.81.21.7
Pavlov. Cond. intertrial magazine entries0.60.92.91.00.4-1.50.61.70.90.90.70.70.90.90.60.8
Pavlov. Cond. lever-magazine prob. diff.0.70.91.3-1.2-1.10.8-0.9-0.6-1.1-1.0-0.9-1.1-0.9-0.9-0.7-1.0
Pavlov. Cond. response bias0.30.40.9-0.6-0.90.3-0.7-0.0-0.8-0.7-0.7-0.8-0.7-0.6-0.4-0.7
Time in closed arm before self-admin0.30.31.3-0.01.1-0.11.0-0.30.60.40.8-0.00.60.60.00.5
Time in closed arm after self-admin0.40.40.7-0.80.40.6-0.5-0.7-0.8-0.8-0.6-0.6-0.7-0.70.20.0
Time in open arm before self-admin0.80.81.71.3-1.3-0.1-1.10.1-0.8-0.5-1.01.0-0.9-0.9-1.1-0.7
Time in open arm after self-admin0.10.10.30.1-0.50.3-0.1-0.20.10.1-0.1-0.00.00.1-0.6-0.6
Bone: periosteal estimation0.71.52.91.61.0-1.71.11.61.31.31.11.21.11.10.00.7
Bone: periosteal perimeter4.47.610.73.32.9-2.83.02.52.82.82.93.02.82.81.72.5
Bone: post-yield work0.10.20.60.0-0.30.3-0.4-0.1-0.3-0.4-0.5-0.1-0.5-0.5-0.8-0.5
Progressive ratio test 1 active lever presses0.30.31.0-1.0-0.10.2-0.60.3-0.6-0.6-0.6-1.0-0.4-0.40.6-0.0
Progressive ratio test 1 breakpoint0.20.30.8-0.9-0.10.1-0.50.4-0.5-0.5-0.5-0.9-0.3-0.30.70.1
Progressive ratio test 1 inactive lever presses0.30.42.4-0.5-0.5-0.9-0.41.50.00.2-0.0-0.50.20.21.00.3
Progressive ratio test 2 active lever presses0.10.10.3-0.4-0.2-0.1-0.10.40.00.1-0.1-0.40.10.10.60.1
Progressive ratio test 2 breakpoint0.10.10.4-0.5-0.1-0.1-0.00.50.00.1-0.1-0.50.10.10.60.1
Progressive ratio test 2 inactive lever presses0.20.30.70.10.5-0.30.70.50.40.40.50.00.60.70.80.4
Incentive Sensitization - Responses0.20.20.50.2-0.3-0.60.20.70.50.60.40.20.40.50.60.3
Incentive Sensitization - Breakpoint0.20.20.40.2-0.2-0.50.30.60.60.70.50.20.50.60.70.3
Sum of active levers in priming session hrs 5-62.52.34.61.01.5-0.71.70.71.81.61.61.11.81.82.11.4
Progressive ratio0.40.61.5-0.6-0.10.8-0.4-1.1-0.7-0.7-0.5-0.8-0.7-0.7-1.2-0.8
Food seeking constrained by brief footshock0.20.20.60.20.7-0.00.3-0.20.40.30.50.20.50.40.70.8
Seeking ratio, punishment vs. effort0.10.10.30.5-0.2-0.4-0.10.50.10.20.10.50.10.10.30.3
Retroperitoneal fat weight0.51.99.30.5-0.2-2.50.23.01.01.30.80.11.11.11.51.1
Reaction time number correct1.93.67.2-1.4-2.71.0-2.1-0.2-2.1-1.9-2.1-1.7-1.9-1.9-2.1-2.2
Reaction time mean minus median0.10.30.7-0.40.60.10.4-0.40.70.60.5-0.20.60.60.80.6
Reaction time mean minus median AUC0.00.10.2-0.20.3-0.00.1-0.10.40.30.20.00.30.30.30.3
Reaction time num false alarms0.00.10.20.4-0.10.20.1-0.40.00.00.20.50.10.1-0.3-0.0
Reaction time num false alarms AUC0.10.20.6-0.0-0.50.6-0.3-0.8-0.4-0.4-0.30.1-0.3-0.4-0.7-0.5
Reaction time trials correct on left1.93.67.2-1.4-2.71.0-2.1-0.2-2.1-1.9-2.1-1.7-1.9-1.9-2.1-2.2
Reaction time trials on left2.03.77.5-1.4-2.71.0-2.2-0.2-2.2-1.9-2.1-1.7-2.0-1.9-2.1-2.3
Reaction time mean0.20.30.60.40.1-0.60.30.40.80.80.50.50.60.50.50.4
Reaction time mean AUC0.00.10.10.1-0.3-0.4-0.10.20.30.40.10.10.20.1-0.1-0.1
Median of all reaction times0.10.20.40.6-0.1-0.60.20.50.50.60.40.60.40.30.20.2
Reaction time omissions0.10.10.3-0.5-0.50.2-0.50.0-0.1-0.2-0.3-0.5-0.2-0.3-0.1-0.2
Reaction time false alarm rate0.40.50.90.70.90.00.9-0.50.80.70.90.90.80.70.50.8
Reaction time premature initiation rate0.30.41.4-0.5-0.51.1-0.5-1.2-0.6-0.6-0.6-0.3-0.6-0.5-0.4-0.7
Reaction time premature initiations1.32.33.8-1.2-1.91.4-1.6-1.1-1.7-1.6-1.7-1.2-1.6-1.5-1.4-1.7
Std. dev. reaction times0.10.10.4-0.6-0.20.5-0.2-0.70.10.0-0.0-0.40.0-0.0-0.2-0.2
Reaction time trials completed2.03.77.5-1.4-2.71.0-2.2-0.2-2.2-1.9-2.1-1.7-2.0-1.9-2.1-2.3
Reaction time trials AUC1.83.57.2-1.3-2.70.9-2.1-0.2-2.1-1.9-2.1-1.6-1.9-1.8-2.1-2.2
Run reversals in cocaine runway, females0.50.51.1-0.4-1.10.7-0.6-0.7-0.5-0.6-0.7-0.5-0.6-0.7-1.0-0.9
Run reversals in cocaine runway, males2.82.84.01.21.3-1.61.71.41.81.81.71.21.91.92.01.8
Latency to leave start box in cocaine runway0.50.61.1-1.0-0.90.7-0.6-0.7-0.8-0.7-0.5-0.9-0.7-0.6-0.7-0.8
Latency to leave start box in cocaine runway, F1.41.73.5-1.3-1.90.8-1.2-0.8-1.2-1.0-1.1-1.4-1.2-1.1-1.7-1.6
Latency to leave start box in cocaine runway, M0.20.20.8-0.00.5-0.00.4-0.00.10.10.40.30.30.30.90.5
Std. dev. time between licks in bursts1.82.54.2-1.4-2.00.6-2.00.1-1.6-1.5-1.8-1.6-1.7-1.7-1.5-1.7
Total sessions with >9 infusions0.50.60.9-0.8-0.30.9-0.6-0.9-0.9-0.8-0.9-0.7-0.8-0.8-0.6-0.6
Short access day 1 total inactive lever presses0.71.01.6-0.7-0.80.7-0.9-0.6-1.1-1.1-1.3-0.7-1.2-1.3-0.9-1.2
Short access day 10 total inactive lever presses0.20.63.80.3-0.0-1.30.02.00.40.50.20.20.40.31.00.6
Short access day 1 total infusions0.91.22.8-0.9-0.51.6-0.6-1.7-1.2-1.1-1.0-0.8-1.0-1.0-1.2-1.2
Short access day 10 total infusions0.30.42.2-0.30.5-0.7-0.11.00.40.50.2-0.20.50.41.51.0
Short access total infusions0.20.20.7-0.8-0.10.6-0.4-0.5-0.5-0.4-0.5-0.7-0.3-0.40.3-0.2
Short access day 1 locomotion0.10.10.5-0.10.70.60.5-0.60.10.10.20.00.10.1-0.1-0.1
Short access day 10 total locomotion0.20.41.3-0.11.1-0.00.9-0.20.50.50.60.10.70.70.90.7
Short access total locomotion0.20.21.0-0.11.00.20.7-0.30.30.20.30.00.40.40.70.4
One hour access (0.3 mA shock)0.10.10.2-0.1-0.4-0.4-0.10.50.10.30.1-0.00.20.20.40.1
Compulsive drug intake0.20.30.9-0.1-0.9-0.5-0.70.7-0.6-0.3-0.5-0.3-0.5-0.5-0.2-0.3
One hour access (shock baseline)0.10.10.30.1-0.4-0.0-0.50.0-0.4-0.2-0.30.3-0.3-0.30.2-0.1
Social response proportion1.01.11.5-1.2-0.51.1-1.0-0.8-1.2-1.2-1.1-1.2-1.2-1.2-0.9-1.0
Social responses1.11.42.6-0.4-0.60.9-1.3-0.8-1.4-1.4-1.4-0.6-1.6-1.6-1.3-1.1
Social time0.20.31.10.1-0.20.5-0.2-0.5-0.5-0.4-0.4-0.1-0.5-0.5-1.1-0.8
Soleus weight0.72.04.61.90.4-2.00.62.21.21.30.91.71.11.01.31.4
Bone: stiffness0.20.30.70.70.8-0.80.80.60.50.50.50.40.30.3-0.6-0.3
Tibialis anterior weight0.00.20.60.6-0.8-0.2-0.50.1-0.3-0.1-0.40.5-0.3-0.3-0.3-0.3
Time to tail flick, vehicle, before self-admin0.10.10.5-0.7-0.20.30.1-0.40.1-0.00.1-0.70.10.1-0.5-0.2
Time to tail flick, vehicle, after self-admin1.41.93.3-0.4-0.81.4-1.1-1.7-1.6-1.6-1.3-0.5-1.6-1.6-1.8-1.5
Time to tail flick, test, before self-admin0.80.93.2-1.8-0.30.4-0.8-0.3-0.9-1.0-0.8-1.7-0.8-0.90.2-0.2
Time to tail flick, test, after self-admin1.01.13.6-1.80.31.2-0.5-1.1-0.8-1.1-0.8-1.9-0.9-0.9-0.1-0.3
Delta time to tail flick, vehicle, before/after SA0.80.81.60.2-1.00.4-1.3-0.4-1.0-0.9-1.2-0.1-1.2-1.2-0.6-0.8
Delta time to tail flick, test, before/after SA0.40.41.01.01.00.30.9-0.60.50.40.60.90.40.5-0.10.2
Tibia length9.024.935.15.84.6-5.95.05.44.85.15.05.15.05.03.24.4
Ambulatory time before self-admin1.52.33.20.31.6-1.51.61.71.81.61.70.01.81.71.51.5
Ambulatory time after self-admin0.10.20.5-0.7-0.3-0.2-0.10.60.30.20.1-0.70.20.20.60.3
Bone: tissue strength0.40.41.40.70.2-1.10.51.20.50.60.50.30.50.5-0.30.0
Total heroin consumption0.91.13.10.41.8-0.21.7-0.21.20.91.20.31.21.20.40.8
Bone: trabecular number0.10.20.60.80.0-0.30.10.30.20.20.20.80.20.20.40.4
Bone: trabecular spacing2.02.63.8-1.6-1.90.7-1.9-0.2-1.6-1.4-1.8-1.9-1.7-1.7-1.7-1.8
Bone: trabecular thickness3.54.46.72.42.0-1.52.11.32.22.12.22.62.22.22.02.2
Bone: trabecular tissue density0.81.22.9-1.7-0.51.3-0.6-1.3-0.8-1.0-0.9-1.6-1.0-1.0-1.1-1.0
Water consumed over 24 hours0.40.51.21.10.7-0.40.60.20.60.60.71.10.60.60.71.0
Number of responses in last shaping day0.20.20.4-0.30.10.7-0.1-0.7-0.6-0.6-0.4-0.2-0.6-0.6-0.2-0.6