Hub : Genes

Narf

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Eye gene expression Narf 0.32 0.19 7.1e-03 0.04 0.05 0.09 0.06 7.8e-02 5.7e-02 1.6e-02 4.5e-02
2 OFC gene expression Narf 0.47 0.13 9.4e-09 0.26 0.24 0.22 0.26 7.3e-07 1.8e-06 4.8e-06 6.4e-07
3 LHb gene expression Narf 0.24 0.12 2.2e-03 -0 0.04 0.03 0.01 3.4e-01 3.9e-02 7.7e-02 1.4e-01
4 NAcc gene expression Narf 0.52 0.09 0.0e+00 0.44 0.45 0.45 0.46 3.3e-56 3.1e-57 3.3e-57 1.2e-59
5 IL gene expression Narf 0.48 0.13 3.3e-10 0.35 0.28 0.29 0.3 3.0e-09 1.5e-07 9.8e-08 6.6e-08
6 Brain mRNA stability Narf 0.05 0.03 1.8e-04 0.06 0.04 0.03 0.04 2.9e-06 2.2e-04 4.8e-04 5.2e-05
7 Brain gene expression Narf 0.7 0.11 0.0e+00 0.45 0.46 0.47 0.46 7.7e-46 7.9e-48 2.2e-48 2.8e-47
8 PL gene expression Narf 0.46 0.11 0.0e+00 0.38 0.38 0.39 0.39 5.2e-44 2.0e-43 5.1e-45 3.1e-45
9 BLA gene expression Narf 0.54 0.11 0.0e+00 0.39 0.4 0.42 0.4 2.4e-22 1.2e-22 6.0e-24 4.3e-23
10 pVTA gene expression Narf 0.28 0.11 2.7e-07 0.12 0.15 0.11 0.12 6.2e-06 3.8e-07 2.6e-05 1.0e-05
11 Liver gene expression Narf 0.1 0.05 9.6e-08 0.06 0.07 0.06 0.05 3.5e-07 6.0e-08 9.3e-07 1.5e-06
12 Adipose gene expression Narf 0.03 0.02 9.2e-04 0 0.02 0.02 0.01 1.3e-01 5.4e-03 1.9e-03 6.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.10.21.1-0.5-0.0-0.4-0.0-0.50.60.30.0-0.0-0.3-0.4-1.1
Area under the delay curve1.31.42.40.6-1.2-0.6-1.31.5-1.51.3-1.31.4-0.9-1.01.2
BMI with tail0.20.72.3-1.40.30.70.7-1.51.2-0.90.4-0.60.40.10.2
BMI without tail0.40.84.90.70.7-0.70.5-0.30.1-0.70.5-0.4-0.51.2-2.2
Body weight1.04.25.5-2.32.42.22.0-2.32.1-2.11.9-2.01.61.8-1.8
Weight adjusted by age3.03.44.6-1.71.81.42.1-2.02.0-2.02.1-2.11.51.2-1.7
Bone surface0.20.32.1-0.20.50.00.4-0.50.7-0.30.4-0.40.20.1-1.5
Bone volume0.20.31.7-0.50.3-0.10.4-0.60.7-0.20.4-0.40.00.1-1.3
Breakpoint value in progressive ratio session0.70.82.0-1.01.41.30.70.4-0.3-0.70.6-0.60.81.30.2
Number of licking bursts0.10.20.50.4-0.5-0.7-0.40.1-0.10.4-0.30.4-0.5-0.3-0.2
Context. condit. distance diff. score0.60.71.71.2-0.7-1.3-0.80.5-0.50.8-0.70.7-1.1-0.5-0.6
Locomotion velocity, session 10.40.51.3-1.00.10.80.5-0.70.6-0.50.5-0.60.90.21.1
Locomotion distance, session 12.22.95.70.9-2.1-1.6-1.91.1-1.31.8-1.81.6-1.7-2.41.5
Locomotion velocity, session 21.82.14.90.4-1.4-0.7-1.41.7-1.81.5-1.41.4-1.0-1.62.2
Locomotion distance, session 21.11.62.60.5-1.3-1.2-1.31.2-1.41.4-1.31.3-1.3-1.61.1
Locomotion velocity, session 30.50.61.5-0.4-0.40.1-0.61.2-1.10.7-0.70.7-0.3-0.91.1
Locomotion distance, session 32.12.33.90.2-1.3-0.7-1.51.9-1.91.7-1.61.6-1.2-1.72.0
Stereotopy head waving bouts, day 30.10.10.4-0.7-0.20.40.2-0.30.4-0.20.2-0.30.4-0.30.5
Stereotopy head waving duration, day 30.10.10.3-0.3-0.60.20.0-0.10.1-0.10.1-0.20.2-0.60.5
Locomotion velocity, session 70.70.81.20.5-0.8-0.8-1.00.9-1.01.1-1.01.0-0.9-1.00.7
Locomotion distance, session 74.05.16.21.6-2.3-2.2-2.42.5-2.42.4-2.42.4-2.3-2.11.8
Stereotopy head waving bouts, day 70.10.10.2-0.5-0.10.30.4-0.50.3-0.40.4-0.40.4-0.1-0.0
Stereotopy head waving duration, day 70.20.20.5-0.50.10.50.5-0.70.5-0.50.5-0.50.60.1-0.4
Locomotion velocity, session 81.31.63.10.9-1.1-1.2-1.40.9-0.91.5-1.61.3-1.6-1.80.1
Locomotion distance, session 82.23.25.11.3-1.8-2.2-1.81.6-1.81.9-1.71.8-2.3-2.00.1
Degree of sensitization distance0.20.20.70.90.0-0.7-0.0-0.10.1-0.00.0-0.0-0.40.4-0.9
Degree of sensitization stereotypy0.10.10.2-0.50.10.30.4-0.50.2-0.40.3-0.30.30.1-0.1
Conditioned locomotion0.60.74.20.40.70.10.5-1.00.9-0.60.6-0.60.20.8-2.1
Cocaine response after cond. corrected0.10.10.3-0.50.60.50.10.00.20.00.1-0.00.30.40.1
Cocaine response after cond. not corrected0.10.20.3-0.10.20.1-0.50.6-0.40.6-0.60.5-0.2-0.10.5
Cocaine response before conditioning1.51.92.51.1-1.1-1.2-1.51.5-1.61.3-1.51.5-1.2-1.51.2
Saline control response0.60.83.80.31.20.50.8-0.50.5-0.80.7-0.70.41.2-1.9
Bone: connectivity density0.40.71.30.8-0.7-1.1-0.80.4-0.20.9-0.70.7-1.1-1.0-0.9
Bone: cortical apparent density0.70.92.00.4-1.2-0.5-0.81.1-1.30.8-0.90.9-0.6-0.91.4
Bone: cortical area4.46.617.1-4.12.72.82.5-2.82.9-2.12.4-2.52.11.0-1.8
Bone: cortical porosity4.14.56.4-2.52.12.52.3-1.71.5-2.42.3-2.22.52.1-0.1
Bone: cortical porosity3.74.05.4-2.32.02.32.2-1.61.5-2.32.2-2.12.32.0-0.4
Bone: cortical thickness6.09.928.3-5.33.13.73.0-3.33.4-2.62.9-3.12.81.4-1.1
Bone: cortical thickness2.63.09.0-3.01.42.01.5-2.02.0-1.51.5-1.61.60.80.4
Bone: cortical tissue density0.71.02.30.6-1.3-0.6-0.91.1-1.30.8-0.90.9-0.6-0.91.5
Condit. Reinf. active minus inactive responses0.91.02.9-0.71.20.61.1-1.10.8-1.01.0-1.00.61.0-1.7
Condit. Reinf. active-inactive response ratio0.50.52.9-0.70.70.50.6-0.60.4-0.40.5-0.60.20.2-1.7
Condit. Reinf. active responses1.31.63.2-0.51.40.61.3-1.31.1-1.41.3-1.20.81.6-1.8
Condit. Reinf. inactive responses0.40.51.60.30.70.10.6-0.70.7-0.80.7-0.60.41.3-0.4
Incentive salience index mean0.40.52.0-0.20.80.20.6-0.80.4-0.70.6-0.50.30.7-1.4
Condit. Reinf. lever presses0.40.51.01.0-0.6-1.0-0.80.4-0.70.7-0.80.9-0.8-0.40.3
Condit. Reinf. active minus inactive responses0.70.93.5-0.80.70.70.7-1.41.3-0.40.7-0.80.40.1-1.9
Condit. Reinf. active-inactive response ratio2.93.05.2-1.61.61.51.7-2.32.1-1.51.7-1.81.51.2-2.1
Condit. Reinf. active responses0.20.21.7-0.20.20.20.1-0.60.70.10.1-0.2-0.1-0.2-1.3
Condit. Reinf. inactive responses0.70.81.20.7-0.8-0.6-1.01.1-0.91.0-1.10.9-1.0-1.00.3
Condit. Reinf. lever presses0.10.20.30.4-0.2-0.5-0.40.5-0.50.4-0.40.4-0.5-0.2-0.3
Condit. Reinf. lever reinforcers received0.10.21.30.10.1-0.1-0.1-0.40.40.2-0.1-0.0-0.3-0.3-1.1
Conditioned reinforcement - actives0.60.60.90.8-0.8-0.8-0.90.9-0.60.9-0.60.8-0.7-0.50.5
Conditioned reinforcement - inactives0.50.62.4-0.51.50.70.60.7-0.6-0.60.6-0.40.41.4-0.2
Conditioned locomotion0.20.21.20.4-0.2-0.4-0.41.1-0.70.5-0.20.3-0.3-0.20.0
Patch foraging indifference point 0 sec0.00.10.40.4-0.0-0.0-0.10.2-0.00.1-0.10.1-0.10.2-0.6
Patch foraging indifference point AUC0.10.10.2-0.3-0.1-0.20.3-0.10.2-0.50.3-0.10.10.40.2
Delay disc. indifference point, 0s delay0.10.20.5-0.4-0.70.1-0.2-0.40.70.4-0.30.2-0.0-0.60.2
Delay disc. indifference point, 16s delay4.24.36.01.7-2.2-1.8-2.22.4-2.42.2-2.22.3-2.0-1.81.5
Delay disc. indifference point, 2s delay0.10.10.5-0.2-0.70.0-0.20.4-0.20.2-0.20.2-0.1-0.30.7
Delay disc. indifference point, 24s delay1.41.43.5-0.0-0.8-0.3-0.91.9-1.90.9-0.91.0-0.6-1.31.8
Delay disc. indifference point, 4s delay0.30.40.90.2-0.6-0.2-0.70.6-0.40.9-0.90.7-0.6-0.70.1
Delay disc. indifference point, 8s delay0.30.30.5-0.1-0.10.3-0.60.6-0.70.7-0.70.7-0.1-0.20.7
Indifference point function ln k1.01.43.00.5-0.9-0.6-1.50.6-0.61.7-1.51.3-1.0-1.70.9
Indifference point function log k1.01.43.00.5-0.9-0.6-1.50.6-0.61.7-1.51.3-1.0-1.70.9
Patch foraging total patch changes 0 sec0.10.10.40.4-0.1-0.1-0.20.4-0.10.2-0.30.3-0.30.1-0.7
Patch foraging total patch changes 12 sec0.20.31.0-0.10.30.20.7-0.20.5-0.80.6-0.50.51.00.1
Patch foraging total patch changes 18 sec0.40.51.00.4-0.9-0.9-0.41.0-0.70.4-0.50.7-0.9-0.5-0.5
Patch foraging total patch changes 24 sec0.20.21.0-0.30.60.10.60.00.2-0.40.5-0.30.10.6-1.0
Patch foraging total patch changes 6 sec0.30.51.0-0.40.60.50.8-0.50.7-0.90.8-0.60.71.0-0.6
Patch foraging time to switch 0 sec0.10.20.70.9-0.5-0.4-0.40.2-0.20.5-0.40.3-0.2-0.50.5
Patch foraging water rate 0 sec0.20.41.4-0.61.00.30.30.4-0.4-0.10.3-0.1-0.11.1-1.2
Patch foraging water rate 12 sec0.10.20.7-0.8-0.4-0.2-0.30.2-0.00.4-0.40.3-0.5-0.30.2
Patch foraging water rate 18 sec0.30.40.8-0.2-0.4-0.6-0.60.5-0.40.9-0.60.6-0.9-0.8-0.7
Patch foraging water rate 24 sec0.30.42.6-0.3-0.4-0.4-0.10.6-0.60.4-0.20.2-0.9-0.3-1.6
Patch foraging water rate 6 sec0.30.40.9-0.9-0.1-0.1-0.60.9-0.80.6-0.70.6-0.7-0.50.8
Seeking ratio, delayed vs. immediate footshock0.50.62.0-0.10.70.30.4-1.31.3-0.30.5-0.70.30.7-1.4
Distance traveled before self-admin1.82.03.6-1.41.91.61.7-0.30.1-1.51.5-1.41.31.3-1.6
Distance traveled after self-admin0.40.51.71.30.2-0.7-0.21.1-1.30.1-0.10.4-0.40.6-0.4
Extensor digitorum longus weight0.31.12.11.4-1.2-1.4-1.2-0.30.11.2-1.11.0-1.2-1.2-0.2
Bone: elastic displacement1.21.32.0-1.11.21.21.4-1.00.7-1.31.3-1.31.10.9-1.1
Bone: elastic work9.412.215.1-3.93.63.63.7-3.73.7-3.43.6-3.73.42.8-2.5
Bone: endosteal estimation0.40.81.51.1-0.9-1.2-0.80.9-0.70.7-0.70.8-1.1-0.8-0.7
Bone: endosteal perimeter0.50.95.8-0.11.10.30.8-0.91.0-0.60.7-0.80.30.4-2.4
Epididymis fat weight0.00.10.20.30.4-0.00.1-0.0-0.1-0.30.10.1-0.00.5-0.2
Delta time in closed arm before/after self-admin0.70.61.30.9-0.7-0.8-1.0-0.70.61.1-1.10.9-0.7-0.5-0.3
Delta time in open arm before/after self-admin0.20.21.0-0.1-0.2-0.20.40.9-1.0-0.30.4-0.2-0.10.10.1
Diff in mean of infusions in LGA sessions0.30.30.60.7-0.1-0.1-0.80.4-0.30.8-0.80.6-0.3-0.10.4
Delay discount exponential model param1.31.42.7-0.41.10.51.2-1.61.6-1.31.3-1.30.91.0-1.4
Extinction: sum of active levers before priming0.50.52.0-1.4-0.20.60.8-0.50.6-0.80.6-0.70.6-0.31.0
Active lever presses in extinction session 60.80.82.5-1.60.81.20.51.0-1.0-0.50.3-0.20.50.31.2
Bone: final force3.25.113.6-3.72.22.62.2-2.32.3-2.02.2-2.31.91.2-1.5
Bone: final moment4.26.915.9-4.02.52.92.6-2.72.8-2.32.6-2.72.21.5-1.9
Food consumed during 24 hour testing period0.10.20.60.50.3-0.10.0-0.60.6-0.00.1-0.10.10.5-0.8
Glucose1.72.56.1-2.51.22.31.5-0.60.6-1.61.3-1.22.11.01.9
Heart weight1.52.14.6-2.10.61.31.7-1.41.6-1.81.8-1.71.40.50.0
Delay discount hyperbolic model param1.31.32.4-0.41.20.51.2-1.61.4-1.31.3-1.30.91.0-1.3
Intermittent access intake day 1-15 change0.50.51.70.41.00.20.40.7-0.6-0.10.5-0.30.11.3-1.1
Intermittent access intake escalation0.50.51.60.80.6-0.1-0.11.3-1.20.20.10.1-0.21.1-0.7
Intermittent access intake escalation 22.22.15.0-1.11.71.31.80.3-0.1-1.71.9-1.61.22.2-0.7
Intermitt. access day 1 inactive lever presses0.50.62.9-0.31.70.90.50.10.1-0.40.4-0.30.61.3-0.6
Intermitt. access day 15 inactive lever presses0.40.41.90.20.3-0.20.11.3-0.80.2-0.00.1-0.50.0-1.4
Intermitt. access escalation Index0.80.72.31.5-0.3-1.0-0.7-0.40.30.6-0.80.7-0.7-0.2-1.5
Intermittent access day 1 total infusions0.10.10.30.00.20.1-0.1-0.50.6-0.00.1-0.10.20.2-0.0
Intermittent access day 15 total infusions0.10.10.40.50.3-0.2-0.10.3-0.30.20.1-0.0-0.10.6-0.7
Intermittent access terminal intake (last 3 days)0.30.31.40.40.60.20.3-0.10.1-0.30.5-0.40.21.2-1.0
Intermittent access total infusions0.10.10.30.60.3-0.1-0.40.2-0.10.5-0.20.2-0.10.3-0.5
Intermittent access day 1 locomotion0.40.41.10.5-0.0-0.3-1.00.7-0.71.0-0.90.9-0.6-0.2-0.1
Intermittent access day 15 total locomotion0.20.20.9-0.00.60.30.00.4-0.40.10.2-0.20.10.5-1.0
Intermittent access total locomotion0.20.30.80.20.50.0-0.50.9-0.90.6-0.40.4-0.30.2-0.3
Intermittent access standard deviation0.70.72.1-1.00.81.10.31.4-0.9-0.20.5-0.30.60.81.5
Left kidney weight0.51.45.1-2.30.61.30.9-1.61.7-0.80.9-1.11.1-0.3-0.0
Right kidney weight0.20.52.2-1.5-0.10.7-0.0-0.80.80.00.0-0.20.4-0.90.7
Cocaine induced anxiety7.99.116.3-3.24.03.13.4-2.52.4-2.93.3-3.22.73.2-1.5
Post-drug Anxiety1.92.15.9-1.92.41.71.6-0.70.7-1.11.5-1.41.21.5-0.7
Baseline Anxiety6.67.010.71.9-2.8-2.3-3.02.7-2.62.9-3.02.9-2.4-3.31.6
Tail length0.72.212.31.01.9-0.11.1-0.20.2-1.11.2-0.90.12.2-3.5
Length with tail0.72.45.4-1.12.31.81.4-1.31.4-1.41.4-1.41.41.8-1.7
Length without tail1.12.37.1-2.71.12.50.9-1.41.6-0.80.8-1.01.80.21.7
Times rat made contact with spout2.93.45.7-0.41.71.22.0-1.81.9-2.32.1-2.11.92.4-1.4
Lifetime Intake0.10.10.30.60.1-0.2-0.50.1-0.00.5-0.30.3-0.20.2-0.2
Liver weight, left0.60.91.8-1.10.61.30.7-0.30.5-1.00.9-0.91.30.71.3
Liver weight, right0.50.92.1-0.51.41.00.9-0.70.8-1.11.0-1.10.91.0-0.5
Locomotor activity0.40.62.10.3-0.9-0.4-0.51.2-1.10.4-0.50.5-0.4-0.71.5
Locomotor testing distance0.91.52.61.1-1.4-1.0-1.41.0-0.91.3-1.41.2-1.0-1.61.0
Locomotor testing rearing0.71.01.91.3-1.0-1.1-0.91.4-1.20.8-1.01.0-1.0-0.60.6
Locomotion in novel chamber0.40.41.00.5-0.6-0.5-0.8-0.20.21.0-0.90.8-0.6-0.9-0.3
Locomotion in novel chamber post-restriction1.11.33.0-0.11.60.60.9-1.41.4-0.80.9-1.00.71.4-1.7
Fecal boli incidents, locomotor time 10.40.41.40.3-0.7-0.8-0.40.8-0.70.3-0.40.6-0.4-0.81.2
Change in fecal boli incidents, locomotor task0.30.32.0-0.30.20.6-0.10.00.00.1-0.10.00.50.61.4
Time >=10cm from walls, locomotor time 11.01.03.91.5-0.6-1.1-0.70.4-0.71.0-0.80.7-1.2-0.4-2.0
Bouts of movement, locomotor time 10.30.31.9-0.1-0.5-0.3-0.4-0.20.30.3-0.40.4-0.0-0.91.4
Total resting periods, locomotor time 10.30.32.3-0.2-0.3-0.1-0.4-0.10.10.2-0.30.30.1-0.81.5
Rest time, locomotor task time 10.30.30.9-0.60.60.40.5-0.20.3-0.60.7-0.60.60.20.9
Distance moved, locomotor task time 10.70.81.31.0-0.4-0.4-0.90.9-1.11.1-1.11.0-0.90.2-0.7
Vertical activity count, locomotor time 10.50.50.90.8-0.8-0.5-0.60.6-0.70.7-0.70.6-0.8-0.1-1.0
Time >=10cm from walls, locomotor time 20.20.21.1-0.5-0.50.10.2-1.00.8-0.00.2-0.30.1-0.5-0.5
Bouts of movement, locomotor time 21.41.53.21.1-0.8-0.8-1.80.5-0.61.7-1.81.6-1.0-1.11.1
Total resting periods, locomotor time 21.81.93.91.4-0.9-1.1-2.00.6-0.71.8-1.91.8-1.2-1.20.9
Rest time, locomotor task time 20.20.20.90.9-0.0-0.4-0.5-0.30.20.4-0.40.4-0.1-0.00.4
Distance moved, locomotor task time 20.10.10.5-0.3-0.70.1-0.40.2-0.40.5-0.40.3-0.2-0.20.4
Vertical activity count, locomotor time 20.40.51.4-0.2-1.2-0.4-0.50.8-0.90.5-0.60.6-0.7-0.80.5
Light reinforcement 10.40.72.61.1-0.1-0.7-0.2-1.51.60.0-0.1-0.1-0.30.3-1.2
Light reinforcement 20.40.51.5-0.10.50.10.6-1.21.2-0.60.6-0.50.30.8-0.9
Bone: marrow area0.40.81.41.0-0.9-1.2-0.80.9-0.80.7-0.70.8-1.1-0.8-0.7
Bone: maximum diameter0.81.43.8-1.91.21.11.1-1.31.4-0.91.0-1.10.70.1-1.6
Bone: maximum force3.15.313.0-3.62.32.52.2-2.42.6-1.92.2-2.31.91.2-1.7
Bone: maximum moment4.17.115.1-3.92.62.82.6-2.93.0-2.32.6-2.72.21.5-2.1
Mean time between licks in bursts1.11.52.50.5-1.6-1.1-1.11.2-1.31.4-1.31.4-1.2-1.21.0
Mean num. licks in bursts1.21.42.2-0.31.31.11.3-1.01.1-1.51.3-1.51.31.5-0.6
Cd content in liver1.11.22.90.0-1.4-0.7-1.01.1-1.21.1-1.11.1-0.9-1.21.7
Co content in liver0.20.20.30.3-0.4-0.6-0.40.5-0.40.5-0.50.5-0.6-0.50.0
Cu content in liver0.91.01.9-1.11.41.31.1-0.50.6-1.11.0-1.01.11.00.0
Fe content in liver1.21.42.91.1-1.2-1.0-1.01.6-1.71.1-1.11.1-1.1-1.10.5
K content in liver0.20.21.10.10.4-0.8-0.10.3-0.20.2-0.00.3-0.60.4-1.0
Mg content in liver1.71.83.61.3-1.0-1.9-1.31.6-1.51.2-1.21.5-1.7-0.6-0.1
Mn content in liver0.20.31.4-1.20.50.50.40.10.1-0.40.5-0.30.40.50.3
Na content in liver0.10.10.20.10.3-0.2-0.30.4-0.30.3-0.30.3-0.3-0.0-0.1
Rb content in liver0.00.10.3-0.10.0-0.30.20.3-0.2-0.10.2-0.2-0.30.0-0.5
Se content in liver0.20.31.60.80.4-0.40.10.1-0.1-0.10.2-0.0-0.10.7-1.3
Sr content in liver1.41.32.2-1.31.01.51.2-1.10.9-1.21.1-1.21.51.0-0.3
Zn content in liver0.10.10.30.20.1-0.2-0.30.5-0.40.4-0.30.3-0.3-0.20.2
Bone: minimum diameter2.03.76.5-2.12.11.61.9-2.22.3-1.61.8-2.01.41.0-2.5
Time in familiar zone, hab. session 10.50.50.7-0.80.70.70.7-0.60.6-0.70.6-0.70.70.70.5
Time in novel zone, hab. session 10.20.20.70.8-0.4-0.5-0.50.1-0.20.5-0.50.4-0.4-0.3-0.1
Total zone transitions, hab. session 10.30.41.50.1-0.6-0.5-0.60.5-0.40.4-0.50.5-0.5-0.81.2
Total locomotion distance, hab. session 10.10.10.40.3-0.4-0.5-0.30.0-0.00.1-0.30.2-0.3-0.60.7
Locomotion velocity, hab. session 10.10.20.50.2-0.4-0.6-0.30.2-0.20.1-0.20.3-0.4-0.70.6
Time in familiar zone, hab. session 20.30.30.70.6-0.7-0.7-0.60.2-0.40.5-0.60.6-0.5-0.30.8
Time in novel zone, hab. session 20.00.00.1-0.3-0.10.2-0.00.2-0.10.1-0.00.0-0.1-0.3-0.2
Total zone transitions, hab. session 20.91.22.40.6-1.5-1.5-1.20.4-0.51.1-1.11.1-1.3-1.50.4
Total locomotion distance, hab. session 20.60.82.21.0-1.2-1.5-0.9-0.1-0.10.8-0.80.8-1.1-1.0-0.2
Locomotion velocity, hab. session 20.40.51.60.8-0.9-1.3-0.7-0.20.00.6-0.60.6-1.0-0.9-0.4
Novel to familiar place preference ratio3.63.74.7-1.72.22.11.9-2.12.0-1.81.9-2.02.01.9-1.4
Novelty place preference3.83.85.0-1.82.22.11.9-2.22.1-1.81.9-2.02.01.8-1.5
Time in novel zone, NPP test2.93.04.0-1.52.01.91.7-2.01.9-1.61.7-1.81.71.6-1.4
Total zone transitions, NPP test2.63.85.42.0-2.1-2.3-2.11.6-1.72.1-1.91.9-2.3-2.20.4
Total locomotion distance, NPP test2.12.84.82.2-1.8-2.2-1.81.3-1.41.6-1.61.6-1.9-1.60.5
Locomotion velocity, NPP test1.21.73.21.8-1.3-1.7-1.40.8-1.01.3-1.21.2-1.5-1.20.4
Intraocular pressure0.20.21.00.70.4-0.2-0.10.6-0.90.1-0.10.2-0.30.2-1.0
Delta distance traveled before/after self-admin1.92.14.42.1-1.5-1.8-1.61.2-1.31.5-1.31.5-1.5-0.60.9
Delta ambulatory time before/after self-admin2.93.26.42.5-1.9-2.1-2.11.3-1.41.9-1.81.9-1.7-1.01.4
Parametrial fat weight0.71.33.8-0.01.10.71.0-1.21.2-1.51.1-1.11.22.00.3
Pavlov. Cond. lever latency2.22.84.01.1-1.7-1.8-1.62.0-1.71.9-1.71.6-2.0-1.90.8
Pavlov. Cond. magazine entry latency3.54.56.8-1.52.62.12.2-2.01.9-2.22.1-2.12.12.5-1.7
Pavlov. Cond. change in total contacts1.51.62.6-1.11.31.61.3-1.01.0-1.61.3-1.21.61.50.1
Pavlov. Cond. index score3.24.15.5-1.32.31.92.0-2.22.1-2.22.1-2.02.02.4-1.6
Pavlov. Cond. latency score3.24.15.5-1.32.21.92.0-2.32.0-2.22.1-2.02.12.3-1.5
Pavlov. Cond. lever contacts0.91.01.6-0.41.21.00.9-1.21.1-1.21.0-0.91.11.3-0.5
Pavlov. Cond. magazine entry number4.75.97.72.0-2.7-2.6-2.62.1-2.12.8-2.62.5-2.6-2.81.3
Pavlov. Cond. intertrial magazine entries0.10.20.60.5-0.6-0.8-0.30.0-0.00.2-0.30.3-0.6-0.2-0.4
Pavlov. Cond. lever-magazine prob. diff.3.34.15.3-1.52.32.02.1-2.12.0-2.22.0-2.02.02.3-1.7
Pavlov. Cond. response bias3.34.05.8-1.52.42.22.0-1.91.9-2.22.0-2.02.22.4-1.1
Pavlov. Cond. lever latency0.10.10.6-0.60.30.60.2-0.00.0-0.20.1-0.20.50.10.8
Pavlov. Cond. magazine entry latency2.83.34.31.7-1.8-1.9-1.82.1-2.11.6-1.71.9-1.8-1.51.7
Pavlov. Cond. change in total contacts0.71.01.31.1-1.0-1.1-1.01.0-0.91.1-1.01.0-1.1-1.00.0
Pavlov. Cond. index score0.81.01.51.1-0.9-1.2-1.01.2-1.20.9-0.91.0-1.1-0.70.6
Pavlov. Cond. latency score0.81.01.71.2-0.9-1.3-1.01.1-1.10.9-0.91.0-1.1-0.80.4
Pavlov. Cond. lever contacts0.20.31.20.8-0.4-0.8-0.20.1-0.20.2-0.10.2-0.6-0.1-1.1
Pavlov. Cond. magazine entry number3.03.75.1-2.01.61.92.0-2.32.2-1.91.9-2.11.91.5-1.7
Pavlov. Cond. intertrial magazine entries0.81.13.5-0.70.90.81.0-1.01.2-0.81.0-1.00.60.8-1.9
Pavlov. Cond. lever-magazine prob. diff.1.01.21.81.3-0.9-1.3-1.11.3-1.31.0-1.01.2-1.1-0.80.7
Pavlov. Cond. response bias0.50.61.11.1-0.8-1.0-0.80.8-0.80.8-0.70.8-0.9-0.40.1
Time in closed arm before self-admin0.50.51.3-1.10.81.00.70.6-0.6-0.70.6-0.50.70.30.6
Time in closed arm after self-admin0.30.30.9-0.70.81.00.10.2-0.30.0-0.10.10.60.50.9
Time in open arm before self-admin0.80.82.60.7-1.0-0.8-0.7-1.51.60.7-0.60.4-0.4-1.0-0.3
Time in open arm after self-admin0.20.21.00.0-1.0-0.7-0.1-0.30.40.1-0.1-0.0-0.5-0.8-0.1
Bone: periosteal estimation0.81.63.9-2.01.21.11.2-1.31.5-1.01.1-1.20.70.2-1.8
Bone: periosteal perimeter3.76.19.1-3.02.62.52.5-2.72.8-2.22.4-2.52.21.5-2.4
Bone: post-yield work0.30.40.80.3-0.5-0.6-0.70.3-0.30.8-0.70.6-0.8-0.9-0.4
Progressive ratio test 1 active lever presses0.20.21.80.70.6-0.1-0.10.1-0.10.2-0.10.1-0.20.5-1.4
Progressive ratio test 1 breakpoint0.30.32.50.60.80.00.1-0.30.3-0.10.2-0.20.10.6-1.6
Progressive ratio test 1 inactive lever presses0.20.31.70.00.80.30.20.1-0.0-0.10.2-0.20.00.8-1.3
Progressive ratio test 2 active lever presses0.10.10.50.10.60.10.2-0.10.2-0.20.4-0.30.10.6-0.7
Progressive ratio test 2 breakpoint0.10.10.70.50.3-0.2-0.1-0.00.00.00.1-0.0-0.20.4-0.8
Progressive ratio test 2 inactive lever presses0.30.30.9-0.50.70.50.4-0.30.5-0.30.5-0.50.30.7-0.9
Incentive Sensitization - Responses0.30.30.60.00.60.10.6-0.70.6-0.70.8-0.70.40.7-0.6
Incentive Sensitization - Breakpoint0.40.40.7-0.10.60.10.7-0.70.6-0.70.8-0.80.40.7-0.6
Sum of active levers in priming session hrs 5-61.61.53.7-1.01.51.31.3-0.50.7-1.51.3-1.21.21.90.3
Progressive ratio0.30.30.90.0-0.6-0.3-0.41.0-0.90.4-0.40.5-0.3-0.70.8
Food seeking constrained by brief footshock0.10.10.2-0.20.30.40.3-0.00.1-0.30.2-0.30.50.3-0.0
Seeking ratio, punishment vs. effort0.10.20.90.30.3-0.00.1-0.70.7-0.10.1-0.20.10.3-0.9
Retroperitoneal fat weight0.93.05.5-0.02.21.11.9-1.31.1-2.12.0-1.71.42.4-2.1
Reaction time number correct2.94.16.81.8-2.4-2.6-2.01.6-1.52.2-2.02.1-2.6-2.1-0.4
Reaction time mean minus median0.30.41.1-0.20.40.60.70.2-0.4-0.70.6-0.50.70.81.1
Reaction time mean minus median AUC0.10.10.20.10.10.30.30.1-0.3-0.30.3-0.20.30.30.5
Reaction time num false alarms0.00.10.3-0.1-0.3-0.20.1-0.50.3-0.20.1-0.10.0-0.4-0.1
Reaction time num false alarms AUC0.20.20.70.4-0.8-0.6-0.4-0.1-0.20.3-0.40.3-0.4-0.80.4
Reaction time trials correct on left2.94.16.81.8-2.4-2.6-2.01.6-1.52.2-2.02.1-2.6-2.1-0.4
Reaction time trials on left3.04.37.11.8-2.5-2.6-2.11.7-1.62.2-2.12.1-2.7-2.2-0.3
Reaction time mean0.20.20.6-0.10.10.20.7-0.50.2-0.80.7-0.60.40.60.0
Reaction time mean AUC0.00.10.10.3-0.4-0.30.3-0.0-0.2-0.40.3-0.2-0.00.10.2
Median of all reaction times0.10.10.3-0.0-0.1-0.00.4-0.50.2-0.60.5-0.40.20.3-0.1
Reaction time omissions0.20.30.80.6-0.7-0.7-0.20.8-0.90.3-0.20.4-0.6-0.10.3
Reaction time false alarm rate0.40.50.9-0.60.50.70.7-1.00.6-0.90.7-0.81.00.40.4
Reaction time premature initiation rate0.30.41.20.3-0.8-0.6-0.70.4-0.40.6-0.60.5-0.4-0.51.1
Reaction time premature initiations1.82.54.11.3-2.0-1.9-1.71.3-1.31.8-1.61.6-1.8-1.60.8
Std. dev. reaction times0.20.21.00.3-0.7-0.30.00.5-0.8-0.00.00.1-0.1-0.21.0
Reaction time trials completed3.04.37.11.8-2.5-2.6-2.11.7-1.62.2-2.12.1-2.7-2.2-0.3
Reaction time trials AUC2.84.06.71.7-2.5-2.5-1.91.6-1.42.1-2.02.0-2.6-2.1-0.5
Run reversals in cocaine runway, females0.50.51.30.7-1.1-1.0-0.50.7-0.60.5-0.50.5-0.8-0.90.1
Run reversals in cocaine runway, males2.82.74.2-1.21.81.62.0-1.21.2-2.02.0-1.81.71.9-0.5
Latency to leave start box in cocaine runway0.60.71.10.9-0.9-0.9-0.71.0-1.00.4-0.70.7-0.6-0.71.0
Latency to leave start box in cocaine runway, F1.31.42.41.1-1.5-1.5-1.01.3-1.30.7-0.91.0-1.2-1.50.8
Latency to leave start box in cocaine runway, M0.10.10.80.40.40.2-0.10.00.0-0.2-0.00.00.30.90.3
Std. dev. time between licks in bursts2.02.44.11.5-1.4-1.8-1.51.5-1.41.8-1.61.7-2.0-1.4-0.6
Total sessions with >9 infusions0.50.61.10.6-0.6-0.6-1.00.7-0.71.0-1.00.9-0.6-0.80.5
Short access day 1 total inactive lever presses0.80.91.41.0-1.1-1.1-1.20.4-0.31.1-1.11.1-1.0-0.80.6
Short access day 10 total inactive lever presses1.41.63.9-0.92.01.21.2-0.70.9-1.01.2-1.10.91.9-1.1
Short access day 1 total infusions0.60.61.10.3-1.0-0.5-0.90.4-0.20.9-1.00.9-0.6-0.91.0
Short access day 10 total infusions0.20.30.90.10.90.40.2-0.20.2-0.10.4-0.40.40.9-0.8
Short access total infusions0.00.00.10.30.1-0.1-0.3-0.00.20.2-0.20.1-0.00.20.1
Short access day 1 locomotion0.20.20.8-0.9-0.30.40.4-0.50.8-0.20.3-0.50.3-0.10.0
Short access day 10 total locomotion0.20.20.6-0.70.50.80.10.1-0.1-0.00.1-0.20.50.60.5
Short access total locomotion0.10.10.3-0.5-0.00.4-0.2-0.20.20.3-0.20.10.2-0.10.3
One hour access (0.3 mA shock)0.30.31.30.30.9-0.10.4-0.30.4-0.30.6-0.40.20.9-1.1
Compulsive drug intake0.10.10.3-0.20.30.20.30.2-0.5-0.40.2-0.10.20.1-0.1
One hour access (shock baseline)0.30.31.01.0-0.0-0.6-0.7-0.50.70.6-0.40.3-0.3-0.0-0.4
Social response proportion1.21.32.40.6-0.9-0.6-1.31.2-1.31.6-1.31.3-1.1-1.00.8
Social responses1.11.43.21.0-1.0-0.6-1.60.3-0.61.8-1.61.3-1.0-1.20.7
Social time0.30.41.10.2-0.8-0.4-0.70.0-0.30.6-0.70.5-0.6-1.00.5
Soleus weight0.51.43.9-0.21.10.51.0-1.61.7-1.01.0-1.00.71.1-2.0
Bone: stiffness0.40.74.6-2.20.51.10.5-0.50.7-0.40.5-0.50.5-0.10.6
Tibialis anterior weight0.10.42.11.4-0.4-0.9-0.5-0.60.50.3-0.40.4-0.5-0.3-0.5
Time to tail flick, vehicle, before self-admin0.20.20.4-0.1-0.0-0.10.60.6-0.4-0.50.5-0.4-0.1-0.1-0.6
Time to tail flick, vehicle, after self-admin1.01.12.80.2-1.4-0.8-1.10.4-0.21.1-1.21.1-0.7-1.71.3
Time to tail flick, test, before self-admin0.90.93.80.60.60.1-0.51.7-1.90.5-0.60.8-0.20.70.9
Time to tail flick, test, after self-admin0.80.82.40.2-0.4-0.3-0.81.5-1.50.9-0.91.0-0.6-0.31.1
Delta time to tail flick, vehicle, before/after SA1.01.01.91.1-1.1-1.0-1.4-0.10.11.2-1.21.1-0.7-0.81.1
Delta time to tail flick, test, before/after SA0.60.51.8-1.3-0.20.60.5-1.11.3-0.40.5-0.60.5-0.20.6
Tibia length8.223.227.6-5.35.25.04.9-5.25.2-4.64.9-5.04.53.6-4.2
Ambulatory time before self-admin2.62.74.7-1.72.21.82.0-0.40.4-1.81.8-1.71.41.5-1.8
Ambulatory time after self-admin0.20.20.80.60.2-0.30.20.7-0.9-0.20.2-0.0-0.20.5-0.6
Bone: tissue strength0.10.10.6-0.7-0.0-0.00.00.1-0.10.1-0.0-0.0-0.3-0.5-0.8
Total heroin consumption1.21.45.4-2.30.91.81.3-0.30.3-1.21.1-1.11.20.40.6
Bone: trabecular number0.10.10.6-0.20.1-0.20.1-0.60.8-0.00.1-0.1-0.00.0-0.6
Bone: trabecular spacing2.22.94.42.1-1.5-1.8-1.71.8-2.01.6-1.71.8-2.0-1.4-0.1
Bone: trabecular thickness3.44.16.4-2.31.91.92.0-2.52.4-1.92.1-2.12.11.8-1.0
Bone: trabecular tissue density0.71.02.80.7-0.9-0.5-0.81.6-1.70.9-0.80.8-0.7-0.91.1
Water consumed over 24 hours0.40.51.2-0.60.60.60.6-1.11.0-0.60.6-0.60.80.6-0.2
Number of responses in last shaping day0.10.10.4-0.60.30.30.1-0.50.6-0.10.1-0.20.10.2-0.4