Hub : Genes

Naca

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Naca 0.05 0.04 2.2e-03 0.05 0.05 0.05 0.05 8.6e-04 1.4e-03 1.1e-03 1.5e-03
2 pVTA gene expression Naca 0.05 0.04 9.9e-03 0.05 0.03 0.02 0.03 4.5e-03 1.5e-02 3.6e-02 1.4e-02
3 Brain gene expression Naca 0.11 0.07 1.5e-09 0.09 0.09 0.08 0.09 1.2e-08 5.4e-09 4.2e-08 1.4e-08
4 PL gene expression Naca 0.07 0.05 6.5e-08 0.04 0.06 0.06 0.06 3.8e-05 1.0e-07 2.1e-07 3.2e-07
5 Liver gene expression Naca 0.11 0.07 2.1e-10 0.04 0.08 0.08 0.08 1.6e-05 1.9e-09 4.8e-09 4.6e-09
6 BLA alternative TSS NM_001198562.2 0.1 0.08 5.8e-03 0.02 0.03 0.01 0.02 2.9e-02 6.0e-03 7.5e-02 2.4e-02
7 BLA alternative TSS NM_001198562.2 0.1 0.08 7.4e-03 0.02 0.03 0.01 0.02 4.1e-02 8.8e-03 1.1e-01 3.9e-02
8 BLA alternative TSS NM_001198580.1 0.1 0.08 7.3e-03 0.02 0.03 0.01 0.02 3.2e-02 7.7e-03 6.5e-02 3.3e-02
9 BLA alternative TSS NM_001198580.1 0.1 0.08 7.9e-03 0.02 0.02 0.01 0.02 3.9e-02 4.4e-02 8.4e-02 3.2e-02
10 Liver alternative TSS NM_001198580.1 0.04 0.03 1.2e-03 0.03 0.01 0.02 0.02 6.4e-04 1.0e-02 1.7e-03 2.5e-03
11 Liver alternative TSS NM_001198580.1 0.02 0.02 8.5e-03 0.01 0.01 0.01 0.01 9.0e-03 6.7e-02 1.0e-02 4.9e-02
12 Adipose gene expression Naca 0.03 0.03 5.7e-03 0.02 0 0 0.01 6.0e-03 1.8e-01 3.5e-01 3.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density3.25.47.70.90.9-1.5-2.1-2.42.82.8-2.8-2.6-2.7-2.72.7
Area under the delay curve0.10.10.20.10.1-0.2-0.3-0.40.40.4-0.4-0.5-0.4-0.40.5
BMI with tail2.58.028.5-5.3-5.24.43.32.50.40.4-0.90.80.70.7-0.7
BMI without tail0.71.43.4-1.7-1.51.81.61.4-0.4-0.40.31.10.80.8-0.8
Body weight0.31.44.2-2.1-2.02.01.51.20.10.1-0.30.50.40.4-0.4
Weight adjusted by age0.40.40.6-0.3-0.10.40.60.7-0.7-0.70.70.80.70.7-0.7
Bone surface6.812.016.01.61.6-2.4-3.3-3.74.04.0-3.9-3.8-3.9-3.93.9
Bone volume7.011.916.41.51.5-2.3-3.2-3.64.04.0-4.0-3.8-3.9-3.93.9
Breakpoint value in progressive ratio session0.60.62.61.61.3-1.1-0.6-0.3-0.6-0.60.70.20.20.2-0.3
Number of licking bursts2.52.95.9-2.4-2.32.32.11.9-1.0-1.00.81.41.41.4-1.4
Context. condit. distance diff. score0.10.10.3-0.3-0.50.50.50.4-0.1-0.10.10.30.20.2-0.2
Locomotion velocity, session 11.41.62.30.60.8-0.7-1.1-1.21.51.4-1.5-1.5-1.4-1.41.4
Locomotion distance, session 12.12.73.41.00.9-1.3-1.7-1.81.81.8-1.7-1.8-1.8-1.81.8
Locomotion velocity, session 23.64.25.12.02.0-2.0-2.2-2.31.91.9-1.8-2.1-2.1-2.12.1
Locomotion distance, session 23.55.07.32.32.3-2.7-2.7-2.61.81.8-1.6-2.2-2.1-2.12.1
Locomotion velocity, session 31.51.86.52.52.5-2.1-1.5-1.1-0.3-0.40.5-0.3-0.2-0.20.2
Locomotion distance, session 30.00.10.10.30.2-0.10.00.1-0.3-0.30.30.00.20.2-0.2
Stereotopy head waving bouts, day 32.22.66.82.52.6-2.6-2.1-1.80.40.4-0.2-0.9-1.0-1.01.0
Stereotopy head waving duration, day 31.41.64.52.02.1-2.0-1.7-1.40.30.3-0.1-0.7-0.8-0.80.8
Locomotion velocity, session 70.30.30.40.30.2-0.5-0.6-0.60.60.6-0.6-0.6-0.6-0.60.6
Locomotion distance, session 70.60.70.8-0.5-0.90.70.90.9-0.8-0.80.80.90.90.9-0.9
Stereotopy head waving bouts, day 71.71.92.71.31.4-1.6-1.6-1.61.21.2-1.1-1.4-1.4-1.41.4
Stereotopy head waving duration, day 72.12.53.21.51.6-1.6-1.8-1.81.51.4-1.4-1.6-1.7-1.71.7
Locomotion velocity, session 83.44.15.22.12.1-2.1-2.3-2.31.81.8-1.7-2.0-2.0-2.02.0
Locomotion distance, session 80.40.61.01.00.8-0.9-0.9-0.90.50.5-0.5-0.7-0.7-0.70.7
Degree of sensitization distance0.20.20.9-0.7-0.90.60.40.30.20.2-0.20.20.00.0-0.0
Degree of sensitization stereotypy0.60.71.00.20.2-0.4-0.7-0.81.01.0-1.0-0.9-1.0-1.01.0
Conditioned locomotion2.22.63.3-1.4-1.61.71.81.8-1.5-1.51.41.61.71.7-1.6
Cocaine response after cond. corrected2.93.24.8-1.9-2.02.22.22.1-1.4-1.41.31.71.71.7-1.7
Cocaine response after cond. not corrected3.33.75.2-2.0-2.22.22.32.2-1.5-1.51.41.91.81.8-1.9
Cocaine response before conditioning0.40.50.90.90.8-0.9-0.9-0.80.40.4-0.3-0.5-0.6-0.60.5
Saline control response0.20.30.6-0.4-0.60.80.70.7-0.4-0.40.30.50.50.5-0.5
Bone: connectivity density1.93.14.30.70.7-1.1-1.6-1.82.12.1-2.1-1.9-2.0-2.02.0
Bone: cortical apparent density0.40.51.7-1.2-1.01.31.00.80.00.0-0.20.30.30.3-0.3
Bone: cortical area1.21.83.9-0.5-0.60.1-0.6-1.01.91.9-2.0-1.4-1.5-1.51.5
Bone: cortical porosity0.40.50.70.20.1-0.4-0.6-0.70.80.8-0.8-0.8-0.8-0.80.8
Bone: cortical porosity0.91.01.70.0-0.1-0.3-0.7-0.91.31.3-1.3-1.1-1.1-1.11.1
Bone: cortical thickness0.50.81.7-1.3-1.30.90.3-0.01.11.1-1.2-0.5-0.6-0.60.6
Bone: cortical thickness0.60.71.4-1.2-1.11.21.11.0-0.5-0.50.40.70.70.7-0.7
Bone: cortical tissue density0.30.41.3-1.0-0.81.10.90.7-0.0-0.0-0.10.30.30.3-0.3
Condit. Reinf. active minus inactive responses0.70.82.31.51.4-1.4-1.1-0.90.10.1-0.0-0.4-0.4-0.40.4
Condit. Reinf. active-inactive response ratio0.20.20.30.40.2-0.10.10.2-0.5-0.50.60.40.50.5-0.4
Condit. Reinf. active responses1.92.34.42.02.0-2.1-1.9-1.80.90.9-0.7-1.2-1.3-1.31.3
Condit. Reinf. inactive responses2.02.43.51.51.6-1.8-1.9-1.81.21.2-1.1-1.5-1.5-1.51.5
Incentive salience index mean1.31.62.51.51.5-1.6-1.5-1.40.90.9-0.8-1.1-1.1-1.11.1
Condit. Reinf. lever presses2.63.44.21.31.4-1.6-1.9-2.01.91.9-1.9-2.0-2.0-2.02.0
Condit. Reinf. active minus inactive responses0.70.81.71.01.1-0.7-0.10.2-1.2-1.21.30.80.80.8-0.8
Condit. Reinf. active-inactive response ratio1.81.93.50.00.40.30.91.2-1.8-1.81.91.51.61.6-1.5
Condit. Reinf. active responses0.30.31.11.01.0-1.0-0.7-0.5-0.3-0.30.4-0.0-0.0-0.00.0
Condit. Reinf. inactive responses0.50.60.90.70.4-0.9-1.0-1.00.70.7-0.7-0.8-0.8-0.80.8
Condit. Reinf. lever presses0.60.92.01.41.3-1.2-0.5-0.2-1.0-1.01.20.60.60.6-0.6
Condit. Reinf. lever reinforcers received0.20.30.50.70.7-0.7-0.3-0.1-0.6-0.60.70.30.30.3-0.3
Conditioned reinforcement - actives0.40.40.70.00.2-0.4-0.6-0.70.80.8-0.8-0.7-0.8-0.80.8
Conditioned reinforcement - inactives1.41.62.8-1.5-1.21.71.61.5-0.9-0.90.81.31.21.2-1.2
Conditioned locomotion0.60.82.41.01.3-1.5-1.3-1.10.30.3-0.1-0.6-0.6-0.60.6
Patch foraging indifference point 0 sec1.01.66.2-2.5-2.21.91.20.70.80.8-1.0-0.3-0.2-0.20.3
Patch foraging indifference point AUC0.10.10.40.70.5-0.6-0.4-0.2-0.3-0.30.40.10.10.1-0.1
Delay disc. indifference point, 0s delay1.82.04.0-0.6-0.4-0.1-0.7-1.11.91.9-2.0-1.6-1.6-1.61.6
Delay disc. indifference point, 16s delay0.10.10.30.60.6-0.6-0.5-0.40.10.1-0.0-0.2-0.2-0.20.2
Delay disc. indifference point, 2s delay0.50.50.9-0.2-0.2-0.1-0.5-0.60.90.9-1.0-0.9-0.8-0.80.8
Delay disc. indifference point, 24s delay0.10.10.6-0.5-0.80.30.10.10.20.2-0.2-0.1-0.1-0.10.1
Delay disc. indifference point, 4s delay1.11.11.50.70.6-1.1-1.2-1.21.01.0-1.0-1.2-1.1-1.11.1
Delay disc. indifference point, 8s delay0.40.40.5-0.4-0.20.50.70.7-0.7-0.70.70.70.70.7-0.7
Indifference point function ln k0.00.10.2-0.4-0.30.50.30.30.10.1-0.10.00.10.1-0.0
Indifference point function log k0.00.10.2-0.4-0.30.50.30.30.10.1-0.10.00.10.1-0.0
Patch foraging total patch changes 0 sec1.01.66.6-2.6-2.31.91.30.80.60.7-0.8-0.1-0.1-0.10.1
Patch foraging total patch changes 12 sec1.31.74.2-2.1-1.91.81.61.5-0.7-0.70.51.01.01.0-1.0
Patch foraging total patch changes 18 sec0.00.00.1-0.2-0.10.10.10.10.00.0-0.0-0.00.00.0-0.0
Patch foraging total patch changes 24 sec0.20.20.5-0.7-0.50.40.2-0.00.50.5-0.6-0.3-0.3-0.30.3
Patch foraging total patch changes 6 sec0.60.93.5-1.9-1.81.51.00.70.30.3-0.50.00.10.1-0.1
Patch foraging time to switch 0 sec0.20.40.7-0.0-0.1-0.0-0.3-0.40.80.8-0.8-0.7-0.7-0.70.7
Patch foraging water rate 0 sec0.81.31.9-1.2-1.11.31.41.3-0.9-0.90.81.21.11.1-1.1
Patch foraging water rate 12 sec1.11.72.6-1.6-1.21.61.61.5-1.0-1.00.91.31.21.2-1.2
Patch foraging water rate 18 sec2.73.75.1-0.7-0.41.31.82.0-2.3-2.32.22.32.22.2-2.2
Patch foraging water rate 24 sec4.96.98.9-2.2-1.72.52.93.0-2.6-2.62.52.82.82.8-2.8
Patch foraging water rate 6 sec1.01.52.70.30.20.40.91.1-1.6-1.61.61.51.41.4-1.4
Seeking ratio, delayed vs. immediate footshock1.21.42.11.31.4-1.4-1.4-1.30.80.8-0.7-1.3-1.0-1.01.0
Distance traveled before self-admin0.40.41.10.80.6-1.1-0.9-0.80.30.3-0.2-0.4-0.5-0.50.5
Distance traveled after self-admin0.20.20.30.20.4-0.6-0.6-0.50.30.3-0.3-0.5-0.4-0.40.4
Extensor digitorum longus weight2.59.723.9-4.4-4.54.94.23.7-1.2-1.20.82.12.22.2-2.1
Bone: elastic displacement0.00.10.1-0.2-0.1-0.1-0.2-0.20.30.3-0.3-0.4-0.3-0.30.3
Bone: elastic work0.40.50.9-0.8-0.80.3-0.1-0.30.90.9-1.0-0.7-0.7-0.70.7
Bone: endosteal estimation0.30.71.5-0.9-1.00.50.0-0.31.11.1-1.2-0.7-0.8-0.80.8
Bone: endosteal perimeter0.81.72.20.70.6-1.2-1.4-1.51.41.4-1.4-1.4-1.5-1.51.5
Epididymis fat weight0.00.10.2-0.1-0.2-0.10.10.2-0.5-0.40.50.40.40.4-0.3
Delta time in closed arm before/after self-admin4.84.75.7-1.9-1.82.02.32.4-2.1-2.12.12.32.32.3-2.3
Delta time in open arm before/after self-admin0.20.20.5-0.6-0.70.60.30.10.50.5-0.6-0.2-0.3-0.30.3
Diff in mean of infusions in LGA sessions0.40.51.61.31.2-1.2-0.8-0.6-0.3-0.30.50.0-0.0-0.00.0
Delay discount exponential model param0.10.10.2-0.2-0.10.30.30.4-0.4-0.40.40.40.40.4-0.4
Extinction: sum of active levers before priming1.31.32.71.40.9-0.8-0.10.3-1.5-1.51.71.11.11.1-1.1
Active lever presses in extinction session 60.60.61.41.10.9-1.2-1.0-0.90.30.3-0.2-0.5-0.5-0.50.6
Bone: final force1.01.73.4-1.6-1.61.00.2-0.31.71.7-1.8-1.1-1.2-1.21.2
Bone: final moment1.01.73.4-1.6-1.60.90.1-0.31.71.7-1.8-1.1-1.2-1.21.2
Food consumed during 24 hour testing period0.20.31.7-0.9-1.30.60.40.30.10.1-0.20.00.10.1-0.1
Glucose0.60.93.3-1.7-1.81.51.10.90.10.1-0.30.10.30.3-0.2
Heart weight0.20.20.40.1-0.00.50.50.6-0.5-0.50.40.60.50.5-0.5
Delay discount hyperbolic model param0.10.10.20.00.10.10.30.3-0.5-0.50.50.50.40.4-0.5
Intermittent access intake day 1-15 change0.10.10.1-0.30.2-0.10.00.1-0.3-0.30.40.30.20.2-0.2
Intermittent access intake escalation1.31.31.9-0.8-0.30.61.01.1-1.4-1.41.41.41.21.2-1.2
Intermittent access intake escalation 20.80.81.6-0.00.20.10.50.7-1.2-1.21.31.01.01.0-1.0
Intermitt. access day 1 inactive lever presses1.21.31.9-0.3-0.50.71.01.2-1.4-1.41.41.31.31.3-1.3
Intermitt. access day 15 inactive lever presses0.50.51.20.40.7-0.20.20.4-1.0-1.01.10.70.80.8-0.8
Intermitt. access escalation Index1.81.62.01.20.6-0.8-1.2-1.31.41.4-1.4-1.4-1.3-1.31.3
Intermittent access day 1 total infusions0.10.10.2-0.5-0.40.40.10.00.40.4-0.5-0.3-0.2-0.20.2
Intermittent access day 15 total infusions0.20.31.0-1.0-0.60.60.60.5-0.3-0.30.20.30.40.4-0.4
Intermittent access terminal intake (last 3 days)0.20.20.4-0.5-0.20.2-0.1-0.20.60.6-0.6-0.5-0.4-0.40.4
Intermittent access total infusions0.20.20.9-0.9-0.60.60.50.40.10.1-0.10.10.10.1-0.1
Intermittent access day 1 locomotion0.00.00.1-0.00.00.10.20.2-0.2-0.20.20.20.20.2-0.2
Intermittent access day 15 total locomotion0.10.10.70.10.8-0.3-0.10.0-0.3-0.30.40.30.20.2-0.2
Intermittent access total locomotion0.10.10.60.20.7-0.5-0.4-0.30.10.1-0.0-0.1-0.2-0.20.2
Intermittent access standard deviation0.20.20.3-0.50.00.10.30.3-0.5-0.50.50.50.40.4-0.4
Left kidney weight0.71.93.00.60.6-0.6-1.1-1.31.71.7-1.7-1.6-1.6-1.61.6
Right kidney weight0.30.91.51.21.1-1.0-1.1-1.10.80.8-0.7-0.9-0.9-0.90.9
Cocaine induced anxiety1.92.23.41.61.7-1.8-1.8-1.81.11.1-1.0-1.5-1.4-1.41.4
Post-drug Anxiety2.83.13.81.21.2-1.5-1.8-1.91.81.8-1.8-1.9-1.9-1.91.9
Baseline Anxiety0.10.10.3-0.0-0.20.30.40.4-0.4-0.40.40.50.40.4-0.4
Tail length1.44.115.13.93.9-2.9-1.8-1.1-1.3-1.31.60.50.40.4-0.5
Length with tail0.72.59.13.03.0-2.4-1.8-1.4-0.0-0.00.2-0.5-0.6-0.60.5
Length without tail0.40.81.4-0.10.0-0.3-0.6-0.81.21.2-1.2-1.1-1.0-1.01.1
Times rat made contact with spout0.91.01.8-1.3-1.31.31.31.2-0.6-0.60.50.80.90.9-0.9
Lifetime Intake0.30.41.4-1.2-0.80.70.30.10.60.6-0.7-0.3-0.3-0.30.3
Liver weight, left1.01.64.2-2.0-1.91.81.61.4-0.5-0.50.41.00.90.9-0.9
Liver weight, right0.20.31.0-0.9-0.61.00.70.50.20.2-0.30.2-0.0-0.0-0.1
Locomotor activity2.43.810.33.23.0-2.6-2.4-2.10.90.8-0.7-1.3-1.3-1.31.4
Locomotor testing distance0.91.53.81.91.9-1.6-1.5-1.30.60.6-0.4-0.9-0.9-0.90.9
Locomotor testing rearing0.10.20.30.20.10.20.30.4-0.5-0.50.50.50.50.5-0.5
Locomotion in novel chamber0.10.20.8-0.7-0.90.60.40.30.00.0-0.10.20.10.1-0.1
Locomotion in novel chamber post-restriction0.81.03.21.81.6-1.8-1.3-1.0-0.2-0.20.3-0.4-0.3-0.30.3
Fecal boli incidents, locomotor time 11.31.51.9-0.9-1.21.31.41.4-1.1-1.11.01.21.21.2-1.3
Change in fecal boli incidents, locomotor task2.12.02.50.91.3-1.3-1.5-1.61.41.4-1.3-1.5-1.5-1.51.5
Time >=10cm from walls, locomotor time 10.80.81.6-0.6-0.40.0-0.4-0.61.21.2-1.3-1.0-1.0-1.01.0
Bouts of movement, locomotor time 10.10.20.60.70.8-0.5-0.3-0.1-0.3-0.30.40.20.20.2-0.2
Total resting periods, locomotor time 10.40.41.71.31.3-0.9-0.7-0.5-0.2-0.20.3-0.1-0.1-0.10.1
Rest time, locomotor task time 10.40.41.01.01.0-0.9-0.8-0.70.30.3-0.3-0.5-0.5-0.50.5
Distance moved, locomotor task time 10.80.91.7-0.5-0.40.1-0.3-0.61.31.3-1.3-1.0-1.0-1.01.0
Vertical activity count, locomotor time 10.60.62.0-1.4-1.01.21.00.8-0.2-0.20.00.40.40.4-0.4
Time >=10cm from walls, locomotor time 20.91.02.9-1.4-1.71.31.21.1-0.5-0.50.40.70.70.7-0.7
Bouts of movement, locomotor time 21.11.21.50.91.0-1.1-1.2-1.21.11.1-1.0-1.2-1.2-1.21.2
Total resting periods, locomotor time 21.51.61.91.01.1-1.1-1.3-1.41.31.2-1.2-1.3-1.3-1.31.3
Rest time, locomotor task time 20.70.81.00.80.6-0.7-0.9-1.00.90.9-0.9-1.0-1.0-1.01.0
Distance moved, locomotor task time 20.70.80.9-0.6-0.70.70.90.9-0.9-0.90.91.01.01.0-1.0
Vertical activity count, locomotor time 22.12.33.3-1.5-1.61.81.81.8-1.2-1.21.11.51.51.5-1.5
Light reinforcement 11.32.36.52.52.4-2.4-2.0-1.70.30.3-0.1-0.8-0.8-0.80.9
Light reinforcement 20.30.31.10.90.7-1.0-0.8-0.70.10.10.0-0.4-0.3-0.30.4
Bone: marrow area0.30.61.3-0.8-0.90.5-0.0-0.31.11.1-1.2-0.7-0.8-0.80.8
Bone: maximum diameter1.52.83.41.31.2-1.4-1.7-1.91.81.8-1.7-1.8-1.8-1.81.8
Bone: maximum force0.91.63.4-1.7-1.81.20.4-0.11.51.5-1.7-0.9-1.0-1.01.0
Bone: maximum moment0.91.63.3-1.7-1.81.20.4-0.11.61.6-1.7-0.9-1.0-1.01.0
Mean time between licks in bursts0.20.30.70.40.5-0.5-0.10.1-0.8-0.80.80.60.60.6-0.6
Mean num. licks in bursts0.50.61.41.21.1-1.1-1.0-0.90.40.4-0.3-0.6-0.6-0.60.6
Cd content in liver0.20.31.2-1.0-1.10.60.50.40.00.0-0.1-0.00.10.1-0.2
Co content in liver0.50.61.41.21.1-0.6-0.10.1-0.9-0.91.00.40.70.7-0.6
Cu content in liver1.21.53.3-0.6-0.70.3-0.4-0.71.61.6-1.7-1.8-1.3-1.31.5
Fe content in liver0.60.81.2-1.1-1.11.01.01.0-0.6-0.60.50.90.70.7-0.9
K content in liver1.21.21.51.10.8-1.1-1.2-1.21.01.0-0.9-1.1-1.1-1.11.1
Mg content in liver1.61.62.10.90.7-1.2-1.4-1.41.31.3-1.2-1.3-1.4-1.41.4
Mn content in liver5.15.87.71.11.1-1.9-2.5-2.62.72.7-2.6-2.6-2.8-2.82.8
Na content in liver0.40.40.60.20.0-0.3-0.5-0.60.80.8-0.8-0.7-0.8-0.80.6
Rb content in liver1.01.32.5-0.6-0.50.0-0.5-0.81.51.5-1.6-1.4-1.3-1.31.3
Se content in liver0.10.10.30.40.2-0.3-0.3-0.30.20.2-0.2-0.6-0.2-0.20.4
Sr content in liver1.41.32.3-0.2-0.10.50.91.0-1.4-1.41.41.51.31.3-1.3
Zn content in liver2.32.54.91.10.8-0.20.61.0-2.1-2.12.21.81.81.8-1.9
Bone: minimum diameter0.61.12.20.0-0.2-0.1-0.6-0.91.51.5-1.5-1.2-1.2-1.21.2
Time in familiar zone, hab. session 11.11.03.31.81.5-1.6-1.0-0.6-0.8-0.81.00.30.30.3-0.3
Time in novel zone, hab. session 11.41.43.0-1.2-1.10.90.1-0.31.61.6-1.7-1.2-1.2-1.21.2
Total zone transitions, hab. session 11.62.33.11.11.1-1.5-1.7-1.71.51.5-1.4-1.8-1.6-1.61.6
Total locomotion distance, hab. session 14.25.97.72.02.1-2.5-2.8-2.82.22.2-2.1-2.6-2.5-2.52.5
Locomotion velocity, hab. session 13.14.36.02.02.2-2.4-2.5-2.41.81.8-1.6-2.1-2.1-2.12.1
Time in familiar zone, hab. session 21.31.43.31.81.7-1.3-0.6-0.1-1.3-1.31.50.70.80.8-0.8
Time in novel zone, hab. session 21.71.73.1-1.8-1.71.30.4-0.01.51.6-1.7-1.0-1.0-1.01.0
Total zone transitions, hab. session 21.92.44.20.10.2-0.5-1.1-1.42.02.0-2.1-1.8-1.8-1.81.8
Total locomotion distance, hab. session 21.41.92.31.21.4-1.3-1.5-1.51.31.3-1.3-1.4-1.4-1.41.4
Locomotion velocity, hab. session 22.12.83.41.31.5-1.5-1.8-1.91.71.7-1.6-1.8-1.8-1.81.8
Novel to familiar place preference ratio1.61.63.4-1.1-1.00.6-0.2-0.61.71.7-1.8-1.3-1.3-1.31.3
Novelty place preference1.31.42.9-0.9-0.80.4-0.3-0.61.61.6-1.7-1.3-1.3-1.31.3
Time in novel zone, NPP test1.31.32.7-1.1-1.00.6-0.1-0.41.51.5-1.6-1.2-1.2-1.21.2
Total zone transitions, NPP test0.50.71.2-0.3-0.2-0.1-0.5-0.61.11.1-1.1-0.9-0.9-0.90.9
Total locomotion distance, NPP test1.01.42.00.30.5-0.7-1.0-1.21.41.4-1.4-1.4-1.4-1.41.4
Locomotion velocity, NPP test1.01.41.80.60.8-0.9-1.2-1.31.31.3-1.3-1.3-1.3-1.31.3
Intraocular pressure0.81.12.20.40.30.10.60.8-1.4-1.41.51.01.31.3-1.3
Delta distance traveled before/after self-admin0.00.00.1-0.00.20.1-0.0-0.10.20.2-0.2-0.3-0.1-0.10.2
Delta ambulatory time before/after self-admin0.30.30.6-0.00.2-0.2-0.4-0.50.70.7-0.7-0.8-0.6-0.60.6
Parametrial fat weight0.10.10.5-0.1-0.30.00.20.3-0.4-0.40.50.70.30.3-0.4
Pavlov. Cond. lever latency1.11.41.8-0.7-1.00.91.21.3-1.3-1.31.31.31.31.3-1.3
Pavlov. Cond. magazine entry latency0.40.51.91.31.4-1.1-0.7-0.4-0.4-0.40.50.20.10.1-0.1
Pavlov. Cond. change in total contacts0.10.10.1-0.4-0.30.30.10.00.30.3-0.3-0.1-0.2-0.20.2
Pavlov. Cond. index score0.70.91.51.11.2-1.1-1.1-1.10.80.8-0.7-0.9-0.9-0.90.9
Pavlov. Cond. latency score1.31.62.11.31.4-1.3-1.4-1.41.21.1-1.1-1.2-1.3-1.31.3
Pavlov. Cond. lever contacts1.72.02.60.80.9-1.0-1.3-1.51.61.6-1.6-1.6-1.6-1.61.6
Pavlov. Cond. magazine entry number0.20.20.8-0.9-0.90.70.50.40.00.0-0.10.10.10.1-0.2
Pavlov. Cond. intertrial magazine entries0.60.71.0-0.2-0.20.40.70.8-1.0-1.01.01.01.01.0-1.0
Pavlov. Cond. lever-magazine prob. diff.0.80.91.51.21.2-1.1-1.1-1.10.70.7-0.6-0.9-0.9-0.90.9
Pavlov. Cond. response bias0.30.41.31.11.0-0.9-0.7-0.60.10.10.0-0.3-0.3-0.30.3
Pavlov. Cond. lever latency0.50.62.2-1.5-1.21.31.00.80.10.1-0.20.30.20.2-0.3
Pavlov. Cond. magazine entry latency0.80.93.01.71.5-1.6-1.3-1.00.10.10.0-0.4-0.5-0.50.4
Pavlov. Cond. change in total contacts0.10.20.70.90.8-0.8-0.5-0.3-0.2-0.20.3-0.00.00.00.0
Pavlov. Cond. index score0.50.72.51.61.3-1.4-1.0-0.8-0.2-0.20.3-0.2-0.2-0.20.2
Pavlov. Cond. latency score0.70.92.91.71.4-1.6-1.2-1.00.10.10.1-0.4-0.4-0.40.4
Pavlov. Cond. lever contacts0.30.41.31.20.9-1.0-0.6-0.4-0.5-0.50.60.10.20.2-0.1
Pavlov. Cond. magazine entry number0.70.92.7-1.7-1.31.51.21.0-0.1-0.10.00.40.50.5-0.4
Pavlov. Cond. intertrial magazine entries0.60.81.7-0.8-0.81.31.21.2-0.7-0.70.60.90.90.9-0.9
Pavlov. Cond. lever-magazine prob. diff.0.60.82.81.71.3-1.5-1.1-0.9-0.0-0.00.2-0.3-0.3-0.30.3
Pavlov. Cond. response bias0.50.62.31.51.3-1.3-0.8-0.5-0.6-0.60.70.10.20.2-0.2
Time in closed arm before self-admin1.11.21.90.40.4-0.5-0.9-1.01.41.4-1.4-1.3-1.3-1.31.3
Time in closed arm after self-admin0.10.10.6-0.7-0.40.50.30.20.20.2-0.2-0.1-0.0-0.00.0
Time in open arm before self-admin0.20.30.5-0.4-0.10.10.30.4-0.6-0.60.70.60.50.5-0.6
Time in open arm after self-admin0.80.82.1-1.4-1.51.21.11.0-0.4-0.40.30.70.70.7-0.7
Bone: periosteal estimation1.12.24.7-0.7-0.80.3-0.5-1.02.12.1-2.2-1.5-1.6-1.61.6
Bone: periosteal perimeter1.42.33.50.30.3-0.8-1.3-1.51.91.9-1.9-1.7-1.8-1.81.8
Bone: post-yield work0.10.10.3-0.3-0.40.60.40.30.10.1-0.20.10.00.0-0.0
Progressive ratio test 1 active lever presses0.40.51.4-1.0-1.11.20.90.7-0.0-0.0-0.10.50.30.3-0.3
Progressive ratio test 1 breakpoint0.40.41.4-1.0-1.21.10.80.60.10.1-0.20.40.20.2-0.2
Progressive ratio test 1 inactive lever presses0.10.10.10.30.20.0-0.1-0.20.30.3-0.4-0.1-0.3-0.30.3
Progressive ratio test 2 active lever presses0.10.10.4-0.6-0.40.60.40.20.30.3-0.30.0-0.1-0.10.1
Progressive ratio test 2 breakpoint0.30.30.7-0.00.2-0.0-0.3-0.40.80.8-0.8-0.6-0.6-0.60.6
Progressive ratio test 2 inactive lever presses0.20.30.6-0.5-0.20.2-0.1-0.30.70.7-0.8-0.5-0.5-0.50.5
Incentive Sensitization - Responses0.10.10.30.30.6-0.3-0.2-0.20.10.1-0.1-0.1-0.1-0.10.1
Incentive Sensitization - Breakpoint0.20.20.50.40.7-0.5-0.5-0.50.30.3-0.3-0.4-0.4-0.40.4
Sum of active levers in priming session hrs 5-60.00.00.20.3-0.0-0.4-0.2-0.2-0.2-0.20.20.10.10.1-0.1
Progressive ratio0.50.61.6-1.2-1.11.31.10.9-0.3-0.30.20.50.50.5-0.6
Food seeking constrained by brief footshock0.40.51.71.21.2-1.3-0.9-0.7-0.2-0.30.4-0.2-0.1-0.10.1
Seeking ratio, punishment vs. effort0.70.82.51.61.5-1.6-1.2-0.9-0.1-0.10.3-0.2-0.3-0.30.3
Retroperitoneal fat weight0.82.77.8-2.5-2.52.82.31.9-0.3-0.30.00.80.90.9-0.8
Reaction time number correct1.31.93.6-1.9-1.71.61.61.5-1.0-1.00.91.31.31.3-1.2
Reaction time mean minus median0.91.25.42.22.3-1.4-1.1-0.90.10.10.0-0.5-0.4-0.40.4
Reaction time mean minus median AUC2.93.87.82.32.8-2.1-2.2-2.11.51.5-1.4-1.7-1.7-1.71.8
Reaction time num false alarms0.30.41.0-1.0-0.61.00.80.8-0.3-0.30.20.50.50.5-0.5
Reaction time num false alarms AUC0.60.81.5-1.1-0.71.21.21.1-0.7-0.70.60.90.80.8-0.9
Reaction time trials correct on left1.31.93.6-1.9-1.71.61.61.5-1.0-1.00.91.31.31.3-1.2
Reaction time trials on left1.21.73.4-1.9-1.71.51.51.4-0.9-0.90.81.21.21.2-1.1
Reaction time mean1.41.94.12.01.8-1.7-1.6-1.50.90.9-0.8-1.2-1.2-1.21.1
Reaction time mean AUC1.01.42.41.61.4-1.3-1.3-1.31.01.0-0.9-1.1-1.1-1.11.0
Median of all reaction times0.91.22.11.41.1-1.3-1.3-1.30.90.9-0.8-1.0-1.1-1.11.0
Reaction time omissions0.10.20.20.10.3-0.2-0.3-0.40.50.5-0.5-0.4-0.5-0.50.4
Reaction time false alarm rate0.00.00.0-0.00.20.20.10.00.20.2-0.2-0.1-0.1-0.10.1
Reaction time premature initiation rate0.81.02.01.41.1-0.60.00.3-1.3-1.31.40.91.01.0-1.0
Reaction time premature initiations1.52.13.90.30.10.30.91.2-1.9-1.92.01.71.71.7-1.7
Std. dev. reaction times1.01.33.61.81.9-1.4-1.3-1.20.60.6-0.5-0.9-0.9-0.90.9
Reaction time trials completed1.21.73.4-1.9-1.71.51.51.4-0.9-0.90.81.21.21.2-1.1
Reaction time trials AUC1.62.34.1-2.0-1.91.71.71.7-1.2-1.21.11.41.41.4-1.3
Run reversals in cocaine runway, females1.01.02.31.11.5-1.5-1.3-1.20.50.5-0.3-0.8-0.8-0.80.7
Run reversals in cocaine runway, males1.51.53.01.71.7-1.7-1.6-1.40.60.6-0.5-0.9-0.9-0.90.9
Latency to leave start box in cocaine runway1.71.82.90.50.5-0.7-1.1-1.31.71.7-1.7-1.7-1.5-1.51.5
Latency to leave start box in cocaine runway, F3.23.55.50.50.5-1.0-1.6-1.92.32.3-2.3-2.2-2.1-2.12.2
Latency to leave start box in cocaine runway, M0.70.71.0-0.1-0.10.60.80.9-1.0-1.01.00.61.01.0-1.0
Std. dev. time between licks in bursts1.21.41.90.71.1-1.2-1.3-1.41.21.2-1.1-1.3-1.3-1.31.3
Total sessions with >9 infusions1.61.83.3-0.7-0.1-0.3-0.9-1.21.81.8-1.8-1.5-1.5-1.51.5
Short access day 1 total inactive lever presses0.00.10.2-0.4-0.00.0-0.1-0.10.30.3-0.3-0.2-0.2-0.20.2
Short access day 10 total inactive lever presses0.60.70.9-0.0-0.10.60.80.9-0.9-0.90.91.00.90.9-0.9
Short access day 1 total infusions1.61.73.7-0.6-0.10.0-0.7-1.01.81.8-1.9-1.4-1.5-1.51.5
Short access day 10 total infusions0.20.30.9-1.0-0.80.70.40.20.40.4-0.5-0.2-0.1-0.10.1
Short access total infusions1.11.22.8-1.0-0.80.5-0.2-0.51.61.6-1.7-1.0-1.1-1.11.1
Short access day 1 locomotion0.40.40.50.40.7-0.5-0.6-0.70.70.7-0.7-0.7-0.7-0.70.7
Short access day 10 total locomotion0.40.41.00.51.0-0.6-0.10.1-0.9-0.91.00.50.50.5-0.5
Short access total locomotion0.20.20.30.30.6-0.5-0.5-0.50.30.3-0.3-0.3-0.4-0.40.4
One hour access (0.3 mA shock)0.20.21.0-1.0-0.60.60.40.30.10.1-0.2-0.00.00.0-0.0
Compulsive drug intake0.00.00.1-0.2-0.20.20.10.00.30.3-0.3-0.3-0.1-0.10.1
One hour access (shock baseline)0.50.61.5-1.2-0.90.70.80.8-0.6-0.60.60.70.70.7-0.7
Social response proportion0.80.92.01.31.4-1.3-1.2-1.00.50.5-0.4-0.7-0.7-0.70.7
Social responses4.55.815.73.84.0-3.6-3.1-2.60.70.7-0.4-1.4-1.5-1.51.5
Social time0.40.51.5-1.0-0.41.21.10.9-0.4-0.40.20.60.60.6-0.6
Soleus weight1.64.814.7-3.7-3.53.82.92.30.10.1-0.50.90.80.8-0.8
Bone: stiffness1.11.74.8-2.2-2.21.81.00.51.21.2-1.4-0.4-0.5-0.50.5
Tibialis anterior weight0.31.13.3-1.7-1.81.81.41.10.10.1-0.20.50.40.4-0.3
Time to tail flick, vehicle, before self-admin3.83.94.91.81.9-2.0-2.2-2.21.81.8-1.7-2.1-2.0-2.02.0
Time to tail flick, vehicle, after self-admin0.70.71.30.30.10.10.50.7-1.1-1.11.11.01.01.0-1.0
Time to tail flick, test, before self-admin2.22.23.31.51.8-1.5-1.6-1.61.31.2-1.2-1.4-1.4-1.41.4
Time to tail flick, test, after self-admin1.11.21.50.40.0-0.9-1.1-1.21.21.2-1.2-1.2-1.2-1.21.2
Delta time to tail flick, vehicle, before/after SA3.53.54.2-1.4-1.61.72.02.1-1.9-1.91.82.02.02.0-2.0
Delta time to tail flick, test, before/after SA0.50.40.7-0.2-0.80.20.50.6-0.8-0.80.80.70.70.7-0.7
Tibia length0.30.83.31.61.8-1.3-0.8-0.5-0.6-0.60.70.10.20.2-0.1
Ambulatory time before self-admin0.10.10.30.3-0.0-0.5-0.4-0.40.10.1-0.1-0.2-0.2-0.20.2
Ambulatory time after self-admin0.10.10.2-0.00.1-0.3-0.3-0.30.30.3-0.3-0.4-0.3-0.30.3
Bone: tissue strength1.21.24.6-2.1-2.21.50.90.60.70.7-0.9-0.2-0.2-0.20.2
Total heroin consumption1.01.13.11.71.3-1.8-1.5-1.30.30.3-0.2-0.7-0.7-0.70.7
Bone: trabecular number2.23.54.51.61.5-1.9-2.1-2.11.81.8-1.7-2.0-1.9-1.91.9
Bone: trabecular spacing4.45.77.3-1.4-1.41.92.42.6-2.6-2.62.62.72.62.6-2.6
Bone: trabecular thickness7.89.413.71.31.1-1.8-2.7-3.13.73.7-3.7-3.5-3.5-3.53.5
Bone: trabecular tissue density2.84.09.6-2.9-2.83.12.72.3-0.8-0.80.51.41.41.4-1.4
Water consumed over 24 hours0.91.02.1-0.6-0.70.2-0.4-0.61.41.4-1.4-1.1-1.1-1.11.1
Number of responses in last shaping day0.20.31.30.61.1-0.8-0.6-0.50.00.00.0-0.2-0.2-0.20.2