Hub : Genes

Naca

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Naca 0.04 0.04 4.2e-03 0.03 0.03 0.04 0.04 6.2e-03 7.3e-03 3.3e-03 3.5e-03
2 NAcc gene expression Naca 0.02 0.01 1.2e-03 0.02 0.02 0.02 0.02 1.5e-04 1.5e-03 7.8e-04 2.8e-04
3 Brain gene expression Naca 0.1 0.06 7.5e-09 0.08 0.09 0.09 0.08 3.9e-08 1.7e-08 2.7e-08 6.6e-08
4 PL gene expression Naca 0.07 0.05 3.4e-08 0.06 0.07 0.07 0.07 1.7e-07 2.0e-08 5.9e-08 5.7e-08
5 Liver gene expression Naca 0.1 0.06 3.7e-10 0.04 0.08 0.08 0.08 2.6e-05 3.2e-09 3.7e-09 9.0e-09
6 pVTA gene expression Naca 0.04 0.04 9.2e-04 0.02 0.03 0 0.02 1.0e-02 2.0e-03 2.0e-01 7.1e-03
7 IC gene expression Naca 0.11 0.08 6.9e-04 0.04 0.06 0.03 0.05 1.1e-02 2.1e-03 1.7e-02 3.8e-03
8 BLA alternative TSS NM_001198580.1 0.1 0.08 9.5e-03 0.02 0 0 0.01 1.9e-02 1.6e-01 1.9e-01 8.9e-02
9 BLA alternative TSS NM_001198562.2 0.11 0.08 5.8e-03 0.03 0.01 0.01 0.02 9.1e-03 1.2e-01 8.4e-02 3.1e-02
10 BLA alternative TSS NM_001198580.1 0.1 0.08 8.2e-03 0.03 0.01 0 0.02 1.3e-02 1.5e-01 2.3e-01 4.8e-02
11 BLA alternative TSS NM_001198562.2 0.11 0.08 5.6e-03 0.03 0.01 0.01 0.02 1.1e-02 1.2e-01 7.7e-02 4.0e-02
12 Liver alternative TSS NM_001198580.1 0.03 0.02 9.2e-03 0.02 0.01 0.01 0.01 2.9e-03 4.2e-02 1.1e-02 1.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density2.54.26.7-0.2-0.5-1.2-1.5-2.0-2.1-2.3-2.62.6-2.62.62.5
Area under the delay curve0.00.10.1-0.3-0.4-0.1-0.1-0.1-0.1-0.2-0.30.3-0.30.30.2
BMI with tail3.010.530.95.65.34.64.23.22.92.20.8-0.80.8-0.8-1.1
BMI without tail0.82.46.52.52.42.22.01.61.51.20.6-0.60.6-0.6-0.7
Body weight0.62.64.82.22.12.22.11.81.71.51.0-1.01.0-1.0-1.1
Weight adjusted by age0.00.10.1-0.2-0.20.00.10.20.20.30.4-0.40.4-0.4-0.3
Bone surface5.39.713.9-0.9-1.3-2.2-2.6-3.2-3.3-3.5-3.73.7-3.73.73.7
Bone volume5.49.714.3-0.7-1.2-2.1-2.5-3.1-3.2-3.5-3.83.8-3.83.83.7
Breakpoint value in progressive ratio session0.20.20.7-0.8-0.6-0.8-0.7-0.5-0.5-0.3-0.10.1-0.10.10.1
Number of licking bursts2.74.35.22.22.32.32.32.12.01.92.1-2.12.1-2.1-1.4
Context. condit. distance diff. score0.30.30.60.70.80.60.60.50.50.40.6-0.60.6-0.6-0.2
Locomotion velocity, session 11.31.42.3-0.2-0.4-0.7-0.8-1.1-1.2-1.3-1.51.5-1.51.51.4
Locomotion distance, session 12.43.04.7-0.7-0.9-1.3-1.5-1.7-1.7-1.8-2.22.2-2.22.21.8
Locomotion velocity, session 24.35.06.1-1.7-1.9-2.1-2.2-2.3-2.3-2.3-2.52.5-2.52.52.1
Locomotion distance, session 25.17.18.1-2.6-2.8-2.8-2.8-2.8-2.7-2.6-2.72.7-2.72.72.1
Locomotion velocity, session 31.41.65.4-2.3-2.1-1.9-1.7-1.2-1.1-0.7-0.00.0-0.00.00.2
Locomotion distance, session 30.00.00.1-0.3-0.2-0.2-0.1-0.0-0.00.1-0.00.0-0.00.0-0.2
Stereotopy head waving bouts, day 32.83.37.5-2.7-2.7-2.4-2.3-1.9-1.7-1.4-1.11.1-1.11.11.0
Stereotopy head waving duration, day 31.72.04.4-2.1-2.1-1.8-1.7-1.5-1.3-1.1-0.90.9-0.90.90.8
Locomotion velocity, session 70.10.10.3-0.2-0.2-0.4-0.4-0.5-0.5-0.5-0.30.3-0.30.30.6
Locomotion distance, session 70.81.01.60.50.60.80.91.01.01.01.3-1.31.3-1.3-0.9
Stereotopy head waving bouts, day 71.82.12.4-1.1-1.1-1.5-1.5-1.6-1.5-1.5-1.51.5-1.51.51.4
Stereotopy head waving duration, day 72.42.93.4-1.2-1.3-1.7-1.8-1.8-1.8-1.8-1.81.8-1.81.81.7
Locomotion velocity, session 83.64.34.8-1.6-1.7-2.0-2.1-2.2-2.2-2.1-2.22.2-2.22.22.0
Locomotion distance, session 80.50.71.0-0.9-0.9-1.0-1.0-0.9-0.9-0.9-0.70.7-0.70.70.7
Degree of sensitization distance0.40.40.80.90.90.80.70.50.50.40.6-0.60.6-0.6-0.0
Degree of sensitization stereotypy0.60.61.10.20.1-0.3-0.5-0.7-0.7-0.8-1.01.0-1.01.01.0
Conditioned locomotion2.12.43.21.11.21.61.71.81.81.81.4-1.41.4-1.4-1.7
Cocaine response after cond. corrected3.33.95.42.12.32.32.32.22.22.11.5-1.51.5-1.5-1.7
Cocaine response after cond. not corrected3.33.95.42.22.32.32.32.32.22.11.5-1.51.5-1.5-1.8
Cocaine response before conditioning0.70.81.1-0.8-1.0-1.1-1.0-1.0-0.9-0.9-0.80.8-0.80.80.6
Saline control response0.40.50.80.70.60.90.90.90.80.80.6-0.60.6-0.6-0.9
Bone: connectivity density1.62.54.4-0.1-0.3-0.9-1.1-1.4-1.5-1.6-2.12.1-2.12.11.8
Bone: cortical apparent density0.30.41.41.21.01.00.90.60.50.3-0.30.3-0.30.3-0.0
Bone: cortical area0.91.32.60.90.7-0.0-0.3-0.8-0.9-1.2-1.51.5-1.51.51.6
Bone: cortical porosity0.40.50.80.20.2-0.4-0.5-0.7-0.7-0.8-0.90.9-0.90.90.8
Bone: cortical porosity0.80.91.50.40.3-0.4-0.6-0.9-0.9-1.1-1.21.2-1.21.21.2
Bone: cortical thickness0.50.81.91.41.10.60.4-0.1-0.3-0.6-1.01.0-1.01.00.9
Bone: cortical thickness0.50.61.11.01.11.01.00.90.90.80.4-0.40.4-0.4-0.7
Bone: cortical tissue density0.20.30.91.00.80.80.70.50.40.2-0.30.3-0.30.3-0.0
Condit. Reinf. active minus inactive responses0.70.71.5-1.2-0.9-1.2-1.2-1.0-0.9-0.7-0.60.6-0.60.60.4
Condit. Reinf. active-inactive response ratio0.10.10.20.20.40.10.20.30.40.40.2-0.20.2-0.2-0.5
Condit. Reinf. active responses2.22.74.3-1.9-1.8-2.1-2.0-1.9-1.8-1.6-1.21.2-1.21.21.3
Condit. Reinf. inactive responses2.42.94.2-2.0-2.1-2.1-2.1-2.0-2.0-1.8-1.11.1-1.11.11.6
Incentive salience index mean1.51.82.3-1.2-1.1-1.5-1.5-1.5-1.4-1.3-1.41.4-1.41.41.1
Condit. Reinf. lever presses2.33.34.2-1.0-1.1-1.6-1.7-1.9-1.9-2.0-2.12.1-2.12.11.9
Condit. Reinf. active minus inactive responses0.60.72.1-1.4-1.2-0.7-0.50.00.20.50.9-0.90.9-0.9-0.8
Condit. Reinf. active-inactive response ratio1.31.52.6-0.4-0.10.40.61.11.21.41.5-1.51.5-1.5-1.6
Condit. Reinf. active responses0.40.52.0-1.4-1.2-1.1-0.9-0.6-0.5-0.30.3-0.30.3-0.30.0
Condit. Reinf. inactive responses0.40.50.9-0.7-0.7-0.9-0.9-0.9-0.9-0.9-0.40.4-0.40.40.8
Condit. Reinf. lever presses0.60.93.5-1.9-1.6-1.1-0.9-0.4-0.20.10.7-0.70.7-0.7-0.5
Condit. Reinf. lever reinforcers received0.30.41.3-1.1-0.9-0.7-0.6-0.2-0.10.10.6-0.60.6-0.6-0.3
Conditioned reinforcement - actives0.10.10.70.70.80.20.20.20.10.1-0.00.0-0.00.0-0.1
Conditioned reinforcement - inactives0.60.91.21.01.01.11.11.11.01.00.7-0.70.7-0.7-0.8
Conditioned locomotion1.01.32.3-1.3-1.2-1.5-1.5-1.3-1.3-1.1-0.90.9-0.90.90.8
Patch foraging indifference point 0 sec0.81.56.22.52.21.81.50.90.70.3-0.20.2-0.20.20.3
Patch foraging indifference point AUC0.10.20.4-0.7-0.4-0.5-0.3-0.1-0.00.10.5-0.50.5-0.5-0.2
Delay disc. indifference point, 0s delay1.11.22.40.60.4-0.0-0.3-0.8-0.9-1.2-1.51.5-1.51.51.5
Delay disc. indifference point, 16s delay0.20.30.8-0.7-0.9-0.6-0.5-0.5-0.5-0.4-0.40.4-0.40.40.3
Delay disc. indifference point, 2s delay0.40.40.8-0.0-0.2-0.1-0.3-0.5-0.6-0.7-0.90.9-0.90.90.8
Delay disc. indifference point, 24s delay0.00.00.10.40.20.30.20.20.20.1-0.10.1-0.10.1-0.0
Delay disc. indifference point, 4s delay1.21.31.5-0.9-1.1-1.0-1.1-1.2-1.2-1.2-1.21.2-1.21.21.1
Delay disc. indifference point, 8s delay0.40.50.60.20.30.60.70.70.80.80.7-0.70.7-0.7-0.8
Indifference point function ln k0.00.10.10.20.10.30.30.20.20.1-0.30.3-0.30.3-0.1
Indifference point function log k0.00.10.10.20.10.30.30.20.20.1-0.30.3-0.30.3-0.1
Patch foraging total patch changes 0 sec0.71.45.72.42.21.71.40.80.70.3-0.20.2-0.20.20.3
Patch foraging total patch changes 12 sec1.31.73.41.81.81.61.61.41.31.11.0-1.01.0-1.0-0.8
Patch foraging total patch changes 18 sec0.00.00.10.20.2-0.1-0.1-0.2-0.2-0.2-0.20.2-0.20.20.3
Patch foraging total patch changes 24 sec0.10.20.70.80.80.30.1-0.1-0.2-0.3-0.20.2-0.20.20.5
Patch foraging total patch changes 6 sec0.61.03.81.91.91.31.10.70.60.30.3-0.30.3-0.30.1
Patch foraging time to switch 0 sec0.20.40.80.30.1-0.1-0.3-0.5-0.6-0.7-0.90.9-0.90.90.8
Patch foraging water rate 0 sec0.71.51.91.11.31.31.41.41.31.31.2-1.21.2-1.2-1.2
Patch foraging water rate 12 sec0.81.62.21.41.51.51.51.41.41.30.9-0.90.9-0.9-1.2
Patch foraging water rate 18 sec2.53.95.60.71.11.41.62.02.12.22.4-2.42.4-2.4-2.3
Patch foraging water rate 24 sec5.17.28.81.92.22.62.72.92.93.02.7-2.72.7-2.7-2.8
Patch foraging water rate 6 sec0.91.32.2-0.10.20.50.71.01.11.31.4-1.41.4-1.4-1.5
Seeking ratio, delayed vs. immediate footshock1.21.52.2-1.4-1.5-1.5-1.5-1.4-1.3-1.2-0.90.9-0.90.91.0
Distance traveled before self-admin0.60.71.7-1.3-1.2-1.2-1.1-0.9-0.8-0.7-0.40.4-0.40.40.4
Distance traveled after self-admin0.00.00.1-0.3-0.2-0.1-0.1-0.0-0.0-0.00.0-0.00.0-0.0-0.0
Extensor digitorum longus weight2.911.623.24.84.64.64.43.73.53.01.9-1.91.9-1.9-2.2
Bone: elastic displacement0.00.10.1-0.1-0.2-0.2-0.2-0.2-0.3-0.3-0.30.3-0.30.30.1
Bone: elastic work0.20.30.60.80.50.30.1-0.2-0.3-0.5-0.60.6-0.60.60.6
Bone: endosteal estimation0.10.31.01.00.90.60.50.10.0-0.2-0.10.1-0.10.10.8
Bone: endosteal perimeter0.81.72.2-0.9-1.0-1.1-1.2-1.4-1.3-1.3-1.51.5-1.51.51.4
Epididymis fat weight0.20.91.50.30.60.40.60.91.01.11.1-1.11.1-1.1-1.2
Delta time in closed arm before/after self-admin5.04.75.81.51.72.22.32.42.42.42.2-2.22.2-2.2-2.2
Delta time in open arm before/after self-admin0.20.20.60.80.70.60.60.50.40.30.1-0.10.1-0.1-0.2
Diff in mean of infusions in LGA sessions0.40.51.5-1.2-1.1-1.1-1.0-0.7-0.6-0.3-0.00.0-0.00.00.0
Delay discount exponential model param0.10.10.20.40.50.20.20.20.20.20.3-0.30.3-0.3-0.2
Extinction: sum of active levers before priming0.30.40.7-0.7-0.3-0.5-0.30.20.30.50.8-0.80.8-0.8-0.8
Active lever presses in extinction session 60.20.20.3-0.2-0.1-0.6-0.6-0.6-0.6-0.5-0.50.5-0.50.50.5
Bone: final force0.71.13.61.91.70.90.5-0.1-0.3-0.7-0.90.9-0.90.91.4
Bone: final moment0.71.13.41.91.60.80.5-0.2-0.3-0.7-1.01.0-1.01.01.4
Food consumed during 24 hour testing period0.00.10.20.40.10.50.40.30.30.20.0-0.00.0-0.0-0.1
Glucose0.50.82.61.61.61.21.10.90.80.60.2-0.20.2-0.2-0.4
Heart weight0.10.20.5-0.3-0.20.10.20.40.40.60.6-0.60.6-0.6-0.7
Delay discount hyperbolic model param0.10.10.30.10.30.10.10.30.30.30.5-0.50.5-0.5-0.4
Intermittent access intake day 1-15 change0.10.20.4-0.10.2-0.10.10.30.40.50.6-0.60.6-0.6-0.7
Intermittent access intake escalation0.10.30.5-0.10.10.00.10.40.40.60.7-0.70.7-0.7-0.7
Intermittent access intake escalation 20.10.10.3-0.5-0.3-0.4-0.3-0.1-0.00.10.3-0.30.3-0.3-0.3
Intermitt. access day 1 inactive lever presses0.41.52.4-0.10.30.50.71.11.21.51.5-1.51.5-1.5-1.5
Intermitt. access day 15 inactive lever presses0.10.31.0-1.0-0.9-0.7-0.6-0.3-0.2-0.00.3-0.30.3-0.3-0.2
Intermitt. access escalation Index0.40.60.8-0.3-0.6-0.4-0.6-0.7-0.8-0.9-0.90.9-0.90.90.9
Intermittent access day 1 total infusions0.20.30.40.40.30.70.70.60.60.50.5-0.50.5-0.5-0.4
Intermittent access day 15 total infusions0.00.00.00.20.10.10.10.10.00.00.0-0.00.0-0.00.0
Intermittent access terminal intake (last 3 days)0.20.20.4-0.1-0.2-0.4-0.4-0.5-0.6-0.6-0.50.5-0.50.50.6
Intermittent access total infusions0.00.00.20.50.40.30.20.10.0-0.1-0.10.1-0.10.10.1
Intermittent access day 1 locomotion0.60.81.10.40.50.80.91.01.01.01.0-1.01.0-1.0-1.0
Intermittent access day 15 total locomotion0.10.20.3-0.2-0.10.10.20.40.40.50.5-0.50.5-0.5-0.5
Intermittent access total locomotion0.10.10.1-0.10.00.10.10.20.20.30.3-0.30.3-0.3-0.4
Intermittent access standard deviation0.30.61.1-1.0-1.0-0.9-0.9-0.9-0.8-0.8-0.50.5-0.50.50.6
Left kidney weight0.00.20.3-0.2-0.30.20.20.40.40.40.5-0.50.5-0.5-0.5
Right kidney weight0.10.40.6-0.8-0.7-0.3-0.10.30.30.50.8-0.80.8-0.8-0.7
Cocaine induced anxiety2.02.94.0-1.3-1.2-2.0-2.0-2.0-2.0-1.9-1.61.6-1.61.61.6
Post-drug Anxiety3.74.05.3-0.9-1.0-1.9-2.0-2.2-2.3-2.3-2.22.2-2.22.22.2
Baseline Anxiety0.00.00.00.0-0.10.10.0-0.0-0.0-0.1-0.10.1-0.10.10.1
Tail length1.14.115.4-3.9-3.6-2.9-2.5-1.7-1.4-0.90.3-0.30.3-0.3-0.0
Length with tail0.41.87.0-2.6-2.5-1.7-1.3-0.6-0.40.00.9-0.90.9-0.9-0.6
Length without tail0.30.91.30.90.81.11.11.11.11.00.9-0.90.9-0.9-0.8
Times rat made contact with spout1.31.52.01.41.41.41.41.31.21.21.1-1.11.1-1.1-0.9
Lifetime Intake0.20.21.01.00.80.60.50.20.1-0.1-0.20.2-0.20.20.3
Liver weight, left0.20.30.60.80.70.70.70.60.50.50.2-0.20.2-0.2-0.4
Liver weight, right0.20.30.7-0.3-0.2-0.00.10.30.40.50.9-0.90.9-0.9-0.6
Locomotor activity2.94.57.3-2.6-2.7-2.7-2.6-2.3-2.3-2.0-1.51.5-1.51.51.4
Locomotor testing distance1.32.43.6-1.7-1.8-1.9-1.9-1.7-1.7-1.5-1.21.2-1.21.21.1
Locomotor testing rearing0.10.10.3-0.00.00.10.10.30.30.40.5-0.50.5-0.5-0.4
Locomotion in novel chamber0.10.10.30.50.60.30.20.20.10.10.3-0.30.3-0.30.0
Locomotion in novel chamber post-restriction1.11.95.4-2.3-2.1-2.1-1.9-1.4-1.2-0.9-0.10.1-0.10.10.4
Fecal boli incidents, locomotor time 10.91.31.61.11.21.21.31.31.31.21.0-1.01.0-1.0-1.0
Change in fecal boli incidents, locomotor task2.02.02.5-1.2-1.3-1.4-1.5-1.6-1.6-1.6-1.31.3-1.31.31.5
Time >=10cm from walls, locomotor time 10.60.71.40.2-0.1-0.2-0.3-0.7-0.7-0.9-1.11.1-1.11.11.2
Bouts of movement, locomotor time 10.20.31.1-1.0-1.0-0.6-0.5-0.2-0.2-0.00.3-0.30.3-0.3-0.2
Total resting periods, locomotor time 10.50.52.0-1.4-1.4-1.0-0.9-0.6-0.5-0.30.1-0.10.1-0.10.0
Rest time, locomotor task time 10.50.71.1-0.9-0.9-1.1-1.0-1.0-0.9-0.8-0.50.5-0.50.50.7
Distance moved, locomotor task time 10.60.91.50.80.60.0-0.2-0.6-0.7-1.0-1.21.2-1.21.21.2
Vertical activity count, locomotor time 10.30.82.71.61.61.21.10.80.80.60.0-0.00.0-0.0-0.3
Time >=10cm from walls, locomotor time 20.71.01.71.01.01.31.31.11.11.00.8-0.80.8-0.8-0.8
Bouts of movement, locomotor time 20.71.21.3-0.9-1.2-1.0-1.0-1.1-1.1-1.1-1.11.1-1.11.11.1
Total resting periods, locomotor time 20.91.61.8-1.0-1.2-1.1-1.2-1.3-1.3-1.3-1.31.3-1.31.31.3
Rest time, locomotor task time 20.70.81.0-0.8-0.9-0.8-0.9-1.0-1.0-1.0-0.90.9-0.90.91.0
Distance moved, locomotor task time 20.50.60.80.50.60.60.70.80.80.80.9-0.90.9-0.9-0.9
Vertical activity count, locomotor time 21.72.32.91.61.61.71.71.71.71.61.3-1.31.3-1.3-1.4
Light reinforcement 11.94.79.3-2.9-3.1-2.8-2.7-2.3-2.2-1.9-1.51.5-1.51.51.2
Light reinforcement 21.01.53.5-1.7-1.9-1.4-1.4-1.1-1.1-1.0-1.01.0-1.01.00.5
Bone: marrow area0.10.20.91.00.90.60.50.10.0-0.2-0.10.1-0.10.10.7
Bone: maximum diameter1.42.63.5-0.8-0.9-1.4-1.5-1.7-1.7-1.7-1.91.9-1.91.91.7
Bone: maximum force0.71.24.22.01.81.10.70.1-0.1-0.5-0.90.9-0.90.91.1
Bone: maximum moment0.61.14.12.01.81.00.70.1-0.1-0.5-0.90.9-0.90.91.1
Mean time between licks in bursts0.10.20.9-1.0-0.8-0.5-0.4-0.1-0.10.10.1-0.10.1-0.1-0.3
Mean num. licks in bursts0.71.11.3-1.0-1.2-1.1-1.1-1.0-1.0-0.9-1.21.2-1.21.20.6
Cd content in liver0.10.10.1-0.3-0.2-0.4-0.4-0.3-0.3-0.30.0-0.00.0-0.00.1
Co content in liver0.70.93.3-1.8-1.8-1.3-1.1-0.6-0.5-0.2-0.20.2-0.20.2-0.4
Cu content in liver0.50.61.70.40.3-0.1-0.3-0.7-0.8-1.0-0.90.9-0.90.91.3
Fe content in liver0.60.70.90.81.00.80.80.80.70.70.9-0.90.9-0.9-0.5
K content in liver1.31.31.7-1.2-1.3-1.3-1.3-1.3-1.3-1.2-0.90.9-0.90.91.0
Mg content in liver0.90.91.7-1.3-1.3-1.3-1.2-1.1-1.1-0.9-0.40.4-0.40.40.8
Mn content in liver5.76.37.2-1.7-1.9-2.3-2.5-2.7-2.7-2.7-2.72.7-2.72.72.6
Na content in liver0.30.30.90.30.3-0.2-0.3-0.5-0.5-0.6-0.70.7-0.70.70.9
Rb content in liver0.60.71.90.1-0.2-0.3-0.5-0.8-0.9-1.0-0.90.9-0.90.91.4
Se content in liver0.00.00.10.10.30.00.00.00.00.00.2-0.20.2-0.2-0.0
Sr content in liver0.40.30.7-0.10.00.10.20.40.40.50.9-0.90.9-0.9-0.7
Zn content in liver1.51.73.2-1.3-0.9-0.4-0.10.50.71.11.8-1.81.8-1.8-1.6
Bone: minimum diameter0.50.91.70.40.2-0.2-0.4-0.7-0.8-1.0-1.31.3-1.31.31.2
Time in familiar zone, hab. session 11.11.14.3-2.1-1.8-1.5-1.2-0.7-0.5-0.20.5-0.50.5-0.5-0.3
Time in novel zone, hab. session 11.11.12.61.61.30.70.4-0.1-0.3-0.7-1.21.2-1.21.21.1
Total zone transitions, hab. session 11.92.73.5-0.9-1.0-1.5-1.6-1.7-1.7-1.7-1.91.9-1.91.91.7
Total locomotion distance, hab. session 14.66.67.6-2.0-2.1-2.6-2.7-2.8-2.8-2.7-2.62.6-2.62.62.5
Locomotion velocity, hab. session 13.85.46.1-2.0-2.1-2.4-2.5-2.5-2.4-2.4-2.32.3-2.32.32.1
Time in familiar zone, hab. session 21.41.45.4-2.3-2.2-1.4-1.1-0.5-0.30.10.8-0.80.8-0.8-0.8
Time in novel zone, hab. session 21.61.65.62.42.21.41.00.30.2-0.3-1.11.1-1.11.11.0
Total zone transitions, hab. session 22.43.16.00.2-0.1-0.7-0.9-1.4-1.5-1.8-2.52.5-2.52.51.9
Total locomotion distance, hab. session 21.92.52.9-1.2-1.4-1.4-1.5-1.6-1.6-1.6-1.71.7-1.71.71.4
Locomotion velocity, hab. session 22.83.74.7-1.3-1.6-1.7-1.8-1.9-2.0-2.0-2.22.2-2.22.21.8
Novel to familiar place preference ratio0.91.02.41.51.40.60.3-0.3-0.4-0.8-1.11.1-1.11.11.3
Novelty place preference0.80.81.61.21.10.40.1-0.4-0.5-0.8-1.01.0-1.01.01.3
Time in novel zone, NPP test0.80.82.21.51.30.60.4-0.2-0.3-0.6-0.90.9-0.90.91.2
Total zone transitions, NPP test0.71.02.10.20.0-0.2-0.4-0.7-0.8-0.9-1.41.4-1.41.41.0
Total locomotion distance, NPP test1.21.72.8-0.4-0.7-0.8-1.0-1.2-1.3-1.4-1.71.7-1.71.71.4
Locomotion velocity, NPP test1.31.82.7-0.8-1.0-1.0-1.1-1.3-1.3-1.4-1.61.6-1.61.61.3
Intraocular pressure0.60.82.1-0.4-0.30.30.50.91.01.21.0-1.01.0-1.0-1.4
Delta distance traveled before/after self-admin0.30.40.70.70.70.80.80.70.70.60.4-0.40.4-0.4-0.4
Delta ambulatory time before/after self-admin0.10.10.30.60.50.50.40.20.20.0-0.10.1-0.10.10.1
Parametrial fat weight0.10.20.80.90.80.60.50.30.20.0-0.20.2-0.20.20.2
Pavlov. Cond. lever latency1.72.13.20.50.61.11.21.51.51.61.8-1.81.8-1.8-1.6
Pavlov. Cond. magazine entry latency0.50.72.1-1.4-1.3-1.2-1.1-0.8-0.8-0.6-0.30.3-0.30.30.2
Pavlov. Cond. change in total contacts0.10.10.30.50.50.30.20.10.1-0.00.0-0.00.0-0.00.2
Pavlov. Cond. index score0.91.11.3-0.9-1.0-1.1-1.2-1.1-1.2-1.1-1.11.1-1.11.10.9
Pavlov. Cond. latency score1.51.92.2-1.0-1.1-1.3-1.4-1.5-1.5-1.5-1.51.5-1.51.51.3
Pavlov. Cond. lever contacts1.51.72.9-0.3-0.4-0.9-1.0-1.3-1.3-1.4-1.71.7-1.71.71.4
Pavlov. Cond. magazine entry number0.20.20.70.80.70.70.60.40.40.2-0.10.1-0.10.1-0.0
Pavlov. Cond. intertrial magazine entries0.60.81.30.00.20.40.60.80.80.91.1-1.11.1-1.1-1.0
Pavlov. Cond. lever-magazine prob. diff.0.80.91.2-0.9-0.9-1.1-1.1-1.1-1.1-1.0-0.90.9-0.90.90.8
Pavlov. Cond. response bias0.20.20.6-0.8-0.7-0.7-0.6-0.5-0.5-0.4-0.10.1-0.10.10.2
Pavlov. Cond. lever latency0.70.93.21.81.71.31.20.90.80.5-0.10.1-0.10.1-0.2
Pavlov. Cond. magazine entry latency1.11.34.0-2.0-1.9-1.6-1.4-1.1-1.0-0.8-0.10.1-0.10.10.4
Pavlov. Cond. change in total contacts0.20.31.3-1.1-1.0-0.8-0.6-0.4-0.3-0.10.2-0.20.2-0.2-0.1
Pavlov. Cond. index score0.71.03.6-1.9-1.8-1.3-1.2-0.8-0.7-0.50.1-0.10.1-0.10.1
Pavlov. Cond. latency score1.01.34.1-2.0-1.9-1.6-1.4-1.1-1.0-0.7-0.10.1-0.10.10.4
Pavlov. Cond. lever contacts0.50.72.7-1.6-1.5-1.1-0.9-0.6-0.4-0.20.4-0.40.4-0.4-0.1
Pavlov. Cond. magazine entry number1.11.34.12.01.91.61.51.21.10.80.1-0.10.1-0.1-0.5
Pavlov. Cond. intertrial magazine entries0.91.32.21.51.51.41.41.21.21.10.8-0.80.8-0.8-0.8
Pavlov. Cond. lever-magazine prob. diff.0.91.23.9-2.0-1.9-1.5-1.4-1.0-0.9-0.7-0.00.0-0.00.00.3
Pavlov. Cond. response bias0.71.03.9-2.0-1.8-1.3-1.1-0.6-0.5-0.20.5-0.50.5-0.5-0.2
Time in closed arm before self-admin0.60.81.2-0.2-0.5-0.5-0.6-0.9-0.9-1.0-1.11.1-1.11.11.1
Time in closed arm after self-admin0.20.20.60.50.30.80.70.60.60.40.3-0.30.3-0.3-0.3
Time in open arm before self-admin0.00.10.20.30.40.20.20.20.20.20.2-0.20.2-0.2-0.1
Time in open arm after self-admin1.11.22.21.51.51.41.31.21.11.00.7-0.70.7-0.7-0.7
Bone: periosteal estimation0.51.12.81.10.90.2-0.0-0.6-0.7-1.0-1.21.2-1.21.21.7
Bone: periosteal perimeter1.22.13.5-0.2-0.4-0.9-1.0-1.4-1.4-1.6-1.91.9-1.91.91.7
Bone: post-yield work0.20.40.90.91.00.80.70.60.50.40.4-0.40.4-0.40.0
Progressive ratio test 1 active lever presses0.30.41.01.01.00.80.70.60.60.50.4-0.40.4-0.4-0.4
Progressive ratio test 1 breakpoint0.40.51.11.01.00.80.80.70.60.50.4-0.40.4-0.4-0.4
Progressive ratio test 1 inactive lever presses0.00.00.1-0.2-0.2-0.3-0.2-0.2-0.2-0.1-0.10.1-0.10.10.0
Progressive ratio test 2 active lever presses0.00.00.00.10.1-0.1-0.1-0.1-0.1-0.1-0.10.1-0.10.10.1
Progressive ratio test 2 breakpoint0.00.00.1-0.1-0.0-0.3-0.3-0.2-0.2-0.2-0.10.1-0.10.10.1
Progressive ratio test 2 inactive lever presses0.20.30.40.60.5-0.1-0.2-0.4-0.5-0.6-0.70.7-0.70.70.6
Incentive Sensitization - Responses0.10.10.4-0.6-0.5-0.5-0.4-0.3-0.2-0.10.0-0.00.0-0.0-0.0
Incentive Sensitization - Breakpoint0.20.20.7-0.8-0.8-0.7-0.6-0.5-0.5-0.3-0.20.2-0.20.20.2
Sum of active levers in priming session hrs 5-60.00.00.0-0.10.0-0.2-0.1-0.00.00.10.1-0.10.1-0.1-0.1
Progressive ratio0.81.32.21.31.31.51.41.31.21.10.8-0.80.8-0.8-0.8
Food seeking constrained by brief footshock0.50.62.1-1.5-1.3-1.2-1.1-0.7-0.6-0.4-0.10.1-0.10.10.0
Seeking ratio, punishment vs. effort1.01.43.6-1.9-1.7-1.7-1.6-1.2-1.1-0.8-0.50.5-0.50.50.4
Retroperitoneal fat weight1.87.712.83.53.63.43.43.12.92.62.0-2.02.0-2.0-2.0
Reaction time number correct1.32.52.81.31.41.61.61.61.61.61.7-1.71.7-1.7-1.3
Reaction time mean minus median0.30.82.2-1.5-1.4-1.3-1.2-1.0-0.9-0.7-0.20.2-0.20.20.4
Reaction time mean minus median AUC1.23.04.2-1.8-1.9-2.0-2.1-2.0-2.0-1.9-1.31.3-1.31.31.7
Reaction time num false alarms0.20.30.80.70.50.90.80.70.60.50.2-0.20.2-0.2-0.4
Reaction time num false alarms AUC0.30.51.00.80.61.01.00.90.90.80.3-0.30.3-0.3-0.7
Reaction time trials correct on left1.32.52.81.31.41.61.61.61.61.61.7-1.71.7-1.7-1.3
Reaction time trials on left1.22.22.61.21.41.51.61.51.51.51.6-1.61.6-1.6-1.2
Reaction time mean1.32.12.7-1.5-1.6-1.6-1.6-1.6-1.6-1.5-1.21.2-1.21.21.2
Reaction time mean AUC0.81.31.7-1.0-1.0-1.2-1.3-1.3-1.3-1.3-1.11.1-1.11.11.1
Median of all reaction times1.21.61.9-1.2-1.2-1.3-1.4-1.4-1.4-1.3-1.21.2-1.21.21.2
Reaction time omissions0.30.40.7-0.2-0.2-0.4-0.5-0.7-0.7-0.8-0.70.7-0.70.70.8
Reaction time false alarm rate0.10.20.40.1-0.20.10.0-0.1-0.2-0.2-0.70.7-0.70.70.2
Reaction time premature initiation rate0.40.51.5-1.2-1.1-0.7-0.40.00.10.40.7-0.70.7-0.7-0.9
Reaction time premature initiations0.81.52.8-0.5-0.20.30.51.01.01.31.7-1.71.7-1.7-1.6
Std. dev. reaction times0.61.01.5-1.2-1.2-1.2-1.2-1.2-1.1-1.1-0.70.7-0.70.70.9
Reaction time trials completed1.22.22.61.21.41.51.61.51.51.51.6-1.61.6-1.6-1.2
Reaction time trials AUC1.52.93.31.31.51.71.81.81.81.71.8-1.81.8-1.8-1.4
Run reversals in cocaine runway, females2.42.43.9-2.0-1.9-1.9-1.8-1.6-1.6-1.4-1.21.2-1.21.21.1
Run reversals in cocaine runway, males2.12.23.3-1.6-1.6-1.8-1.8-1.7-1.6-1.5-1.21.2-1.21.21.2
Latency to leave start box in cocaine runway1.11.32.0-0.3-0.5-0.8-0.9-1.2-1.3-1.4-1.31.3-1.31.31.4
Latency to leave start box in cocaine runway, F2.02.23.4-0.4-0.6-1.0-1.2-1.6-1.6-1.8-1.71.7-1.71.71.8
Latency to leave start box in cocaine runway, M0.20.20.30.20.30.30.30.40.40.40.5-0.50.5-0.5-0.5
Std. dev. time between licks in bursts1.11.51.8-1.1-1.1-1.3-1.3-1.3-1.3-1.3-1.21.2-1.21.21.2
Total sessions with >9 infusions0.20.20.80.90.70.50.40.10.0-0.2-0.30.3-0.30.30.3
Short access day 1 total inactive lever presses0.10.20.5-0.7-0.7-0.1-0.00.20.30.40.4-0.40.4-0.4-0.5
Short access day 10 total inactive lever presses0.71.72.50.10.30.81.01.31.41.61.5-1.51.5-1.5-1.6
Short access day 1 total infusions0.10.20.80.90.70.60.40.10.1-0.1-0.30.3-0.30.30.3
Short access day 10 total infusions0.10.10.30.50.40.60.50.40.40.30.2-0.20.2-0.2-0.2
Short access total infusions0.20.20.91.00.70.70.50.20.1-0.1-0.30.3-0.30.30.4
Short access day 1 locomotion0.10.10.2-0.4-0.4-0.1-0.00.10.20.20.3-0.30.3-0.3-0.4
Short access day 10 total locomotion0.50.91.7-0.7-0.4-0.10.20.70.81.11.2-1.21.2-1.2-1.3
Short access total locomotion0.10.10.3-0.2-0.10.00.10.30.30.40.5-0.50.5-0.5-0.5
One hour access (0.3 mA shock)0.30.30.90.81.00.60.60.50.50.50.4-0.40.4-0.4-0.4
Compulsive drug intake0.10.20.3-0.4-0.5-0.4-0.4-0.4-0.4-0.4-0.40.4-0.40.40.4
One hour access (shock baseline)0.10.10.30.40.50.20.20.30.30.30.4-0.40.4-0.4-0.3
Social response proportion0.80.92.0-1.4-1.4-1.2-1.2-1.0-1.0-0.8-0.30.3-0.30.30.6
Social responses5.36.814.7-3.8-3.8-3.5-3.3-2.8-2.6-2.2-1.41.4-1.41.41.4
Social time0.81.01.81.31.31.31.31.11.10.90.7-0.70.7-0.7-0.7
Soleus weight1.95.518.04.23.83.43.12.32.01.40.1-0.10.1-0.1-0.7
Bone: stiffness1.01.66.72.62.51.71.40.70.60.2-0.10.1-0.10.10.7
Tibialis anterior weight0.51.65.12.32.11.91.71.21.10.80.2-0.20.2-0.2-0.4
Time to tail flick, vehicle, before self-admin1.71.82.4-1.4-1.5-1.4-1.5-1.4-1.4-1.4-1.11.1-1.11.11.2
Time to tail flick, vehicle, after self-admin0.71.01.7-0.4-0.10.30.50.90.91.11.3-1.31.3-1.3-1.3
Time to tail flick, test, before self-admin1.81.92.3-1.2-1.4-1.4-1.4-1.5-1.5-1.5-1.31.3-1.31.31.3
Time to tail flick, test, after self-admin0.20.20.4-0.2-0.3-0.3-0.4-0.5-0.5-0.6-0.60.6-0.60.60.6
Delta time to tail flick, vehicle, before/after SA3.23.03.71.31.51.71.81.91.91.91.7-1.71.7-1.7-1.7
Delta time to tail flick, test, before/after SA1.11.11.50.40.50.80.91.11.21.21.2-1.21.2-1.2-1.2
Tibia length0.30.72.7-1.6-1.5-1.1-0.9-0.5-0.4-0.10.4-0.40.4-0.4-0.2
Ambulatory time before self-admin0.10.10.4-0.5-0.4-0.6-0.6-0.4-0.4-0.3-0.20.2-0.20.20.1
Ambulatory time after self-admin0.00.00.0-0.00.0-0.1-0.1-0.1-0.1-0.1-0.10.1-0.10.10.1
Bone: tissue strength1.41.56.12.52.31.71.40.80.70.3-0.10.1-0.10.10.3
Total heroin consumption1.31.62.9-1.7-1.6-1.7-1.6-1.4-1.3-1.1-0.80.8-0.80.80.8
Bone: trabecular number1.93.14.3-1.0-1.1-1.6-1.7-1.8-1.8-1.8-2.12.1-2.12.11.7
Bone: trabecular spacing3.14.16.20.70.91.71.92.22.32.42.2-2.22.2-2.2-2.5
Bone: trabecular thickness5.46.811.4-0.4-0.7-1.8-2.1-2.7-2.9-3.1-3.03.0-3.03.03.4
Bone: trabecular tissue density3.14.58.42.92.82.82.72.32.21.91.4-1.41.4-1.4-1.2
Water consumed over 24 hours0.30.40.70.60.30.2-0.0-0.3-0.4-0.6-0.80.8-0.80.80.8
Number of responses in last shaping day0.20.20.4-0.7-0.3-0.7-0.5-0.1-0.00.20.4-0.40.4-0.4-0.5