Hub : Genes

Nabp2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Eye	alternative TSS	NM_001244819.1	0.3	0.18	4.9e-03	0.06	0.01	-0.02	0.04	3.7e-02	2.2e-01	9.7e-01	9.8e-02
2	PL	gene expression	Nabp2	0.03	0.03	8.8e-04	0.01	0.02	0.02	0.01	2.1e-02	2.2e-03	5.8e-03	7.6e-03
3	NAcc	gene expression	Nabp2	0.04	0.03	1.4e-04	0.03	0.03	0.03	0.03	8.4e-05	2.3e-04	1.7e-04	2.6e-04
4	Liver	gene expression	Nabp2	0.06	0.05	1.0e-04	0.04	0.03	0.03	0.03	8.8e-05	2.7e-04	5.0e-04	2.0e-04
5	Adipose	gene expression	Nabp2	0.07	0.04	7.8e-06	0.05	0.04	0.04	0.04	2.2e-06	1.7e-05	2.2e-05	9.2e-06
6	Brain	gene expression	Nabp2	0.04	0.03	4.2e-03	0.02	0.01	0.01	0.02	2.7e-03	2.3e-02	4.4e-02	7.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	3.5	5.9	7.1	0.9	-2.5	2.7	2.7	2.7	2.7
Area under the delay curve	0.2	0.2	0.4	0.6	-0.4	0.5	0.4	0.4	0.5
BMI with tail	1.7	5.6	27.1	5.2	2.2	-0.7	-0.7	-0.7	-0.6
BMI without tail	0.6	1.2	2.8	1.7	1.3	-0.9	-0.8	-0.8	-0.8
Body weight	0.4	1.5	7.1	2.7	1.1	-0.5	-0.4	-0.4	-0.3
Weight adjusted by age	0.4	0.5	0.7	-0.3	0.7	-0.8	-0.7	-0.7	-0.7
Bone surface	7.1	12.5	15.3	0.5	-3.7	3.9	3.9	3.9	3.9
Bone volume	7.4	12.5	15.3	0.9	-3.7	3.9	3.9	3.9	3.9
Breakpoint value in progressive ratio session	0.7	0.8	4.1	-2.0	-0.2	-0.5	-0.3	-0.2	-0.2
Number of licking bursts	2.0	2.4	3.4	1.8	1.8	-1.4	-1.4	-1.4	-1.4
Context. condit. distance diff. score	0.1	0.1	0.1	0.4	0.4	-0.2	-0.2	-0.2	-0.2
Locomotion velocity, session 1	1.6	1.7	2.0	0.9	-1.2	1.4	1.4	1.4	1.4
Locomotion distance, session 1	2.2	2.8	3.4	0.1	-1.8	1.8	1.8	1.8	1.8
Locomotion velocity, session 2	3.3	3.9	5.0	-0.8	-2.2	2.1	2.1	2.1	2.1
Locomotion distance, session 2	3.1	4.3	6.5	-1.0	-2.6	2.1	2.1	2.1	2.2
Locomotion velocity, session 3	1.0	1.2	5.9	-2.4	-0.9	0.2	0.2	0.2	0.2
Locomotion distance, session 3	0.0	0.1	0.1	-0.2	0.1	-0.2	-0.2	-0.2	-0.2
Stereotopy head waving bouts, day 3	1.9	2.2	6.7	-2.6	-1.7	1.0	1.0	1.0	1.0
Stereotopy head waving duration, day 3	1.4	1.6	5.7	-2.4	-1.3	0.8	0.8	0.8	0.8
Locomotion velocity, session 7	0.3	0.3	0.4	-0.3	-0.6	0.6	0.6	0.6	0.6
Locomotion distance, session 7	0.5	0.7	0.8	-0.0	0.9	-0.9	-0.9	-0.9	-0.9
Stereotopy head waving bouts, day 7	1.6	1.8	2.5	-0.5	-1.6	1.4	1.4	1.4	1.4
Stereotopy head waving duration, day 7	1.9	2.4	3.2	-0.2	-1.8	1.7	1.7	1.7	1.7
Locomotion velocity, session 8	3.0	3.6	5.1	-0.3	-2.3	2.0	2.0	2.0	2.0
Locomotion distance, session 8	0.3	0.5	0.8	-0.3	-0.9	0.7	0.7	0.7	0.7
Degree of sensitization distance	0.1	0.1	0.5	0.7	0.3	-0.0	-0.0	-0.0	-0.0
Degree of sensitization stereotypy	0.8	0.9	1.0	0.8	-0.8	1.0	1.0	1.0	1.0
Conditioned locomotion	2.1	2.4	3.3	0.7	1.8	-1.6	-1.7	-1.7	-1.6
Cocaine response after cond. corrected	2.5	2.9	4.0	1.2	2.0	-1.7	-1.7	-1.7	-1.7
Cocaine response after cond. not corrected	2.9	3.2	4.6	1.1	2.1	-1.8	-1.8	-1.8	-1.9
Cocaine response before conditioning	0.3	0.4	0.7	-0.8	-0.7	0.5	0.6	0.6	0.5
Saline control response	0.3	0.4	0.7	0.8	0.7	-0.5	-0.5	-0.5	-0.5
Bone: connectivity density	2.1	3.3	4.0	0.6	-1.8	2.0	2.0	2.0	2.0
Bone: cortical apparent density	0.3	0.4	1.7	1.3	0.7	-0.3	-0.3	-0.3	-0.4
Bone: cortical area	1.3	2.0	2.3	1.3	-1.1	1.5	1.5	1.5	1.5
Bone: cortical porosity	0.4	0.5	0.6	-0.2	-0.7	0.8	0.8	0.8	0.7
Bone: cortical porosity	0.9	1.0	1.3	0.4	-0.9	1.1	1.1	1.1	1.1
Bone: cortical thickness	0.4	0.7	2.4	1.5	-0.1	0.6	0.6	0.6	0.6
Bone: cortical thickness	0.5	0.6	0.9	0.8	0.9	-0.7	-0.7	-0.7	-0.7
Bone: cortical tissue density	0.3	0.3	1.2	1.1	0.6	-0.3	-0.3	-0.3	-0.4
Condit. Reinf. active minus inactive responses	0.7	0.7	2.9	-1.7	-0.9	0.4	0.4	0.4	0.4
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.9	-1.0	0.3	-0.5	-0.5	-0.5	-0.4
Condit. Reinf. active responses	1.7	2.1	3.2	-1.8	-1.7	1.3	1.3	1.3	1.3
Condit. Reinf. inactive responses	1.9	2.2	3.3	-0.9	-1.8	1.5	1.5	1.5	1.5
Incentive salience index mean	1.1	1.4	2.0	-1.1	-1.4	1.1	1.1	1.1	1.1
Condit. Reinf. lever presses	2.6	3.5	4.2	0.3	-2.1	2.0	2.0	2.0	2.0
Condit. Reinf. active minus inactive responses	1.0	1.2	4.7	-2.2	0.3	-0.8	-0.8	-0.8	-0.8
Condit. Reinf. active-inactive response ratio	2.1	2.2	2.6	-1.3	1.3	-1.6	-1.6	-1.6	-1.5
Condit. Reinf. active responses	0.4	0.6	3.2	-1.8	-0.4	-0.1	0.0	0.0	0.0
Condit. Reinf. inactive responses	0.5	0.6	0.9	-0.5	-0.9	0.8	0.8	0.8	0.8
Condit. Reinf. lever presses	0.8	1.1	4.9	-2.2	-0.0	-0.7	-0.6	-0.6	-0.6
Condit. Reinf. lever reinforcers received	0.4	0.5	2.7	-1.6	-0.0	-0.4	-0.3	-0.3	-0.3
Conditioned reinforcement - actives	0.5	0.5	0.7	-0.3	-0.7	0.8	0.8	0.8	0.8
Conditioned reinforcement - inactives	1.2	1.3	2.4	0.1	1.5	-1.2	-1.2	-1.2	-1.1
Conditioned locomotion	1.2	1.5	6.1	-2.5	-1.0	0.7	0.6	0.6	0.6
Patch foraging indifference point 0 sec	0.6	1.0	5.7	2.4	0.6	0.1	0.2	0.2	0.3
Patch foraging indifference point AUC	0.1	0.1	0.4	-0.6	-0.2	0.0	-0.1	-0.1	-0.1
Delay disc. indifference point, 0s delay	2.6	2.9	4.4	2.1	-1.2	1.8	1.6	1.6	1.6
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	-0.4	-0.4	0.3	0.2	0.2	0.2
Delay disc. indifference point, 2s delay	0.6	0.7	1.1	1.0	-0.7	0.7	0.8	0.8	0.7
Delay disc. indifference point, 24s delay	0.2	0.1	0.8	0.9	0.0	0.2	0.1	0.1	0.2
Delay disc. indifference point, 4s delay	1.1	1.1	1.6	0.0	-1.3	1.2	1.1	1.1	1.1
Delay disc. indifference point, 8s delay	0.4	0.4	0.5	0.5	0.7	-0.7	-0.7	-0.7	-0.6
Indifference point function ln k	0.0	0.0	0.1	0.0	0.3	-0.3	-0.1	-0.1	-0.0
Indifference point function log k	0.0	0.0	0.1	0.0	0.3	-0.3	-0.1	-0.1	-0.0
Patch foraging total patch changes 0 sec	0.6	0.9	4.8	2.2	0.8	-0.1	0.1	0.1	0.1
Patch foraging total patch changes 12 sec	1.0	1.3	1.9	1.4	1.4	-0.9	-1.0	-1.0	-1.0
Patch foraging total patch changes 18 sec	0.0	0.0	0.0	0.2	0.1	0.1	-0.0	-0.0	-0.0
Patch foraging total patch changes 24 sec	0.2	0.3	1.2	1.1	-0.1	0.4	0.3	0.3	0.3
Patch foraging total patch changes 6 sec	0.3	0.5	2.6	1.6	0.6	-0.1	-0.1	-0.1	-0.1
Patch foraging time to switch 0 sec	0.4	0.6	1.1	1.1	-0.5	0.9	0.7	0.7	0.6
Patch foraging water rate 0 sec	0.8	1.2	1.8	0.3	1.3	-1.3	-1.1	-1.1	-1.1
Patch foraging water rate 12 sec	1.0	1.5	2.3	0.4	1.5	-1.5	-1.2	-1.2	-1.2
Patch foraging water rate 18 sec	3.2	4.4	6.1	-0.9	2.1	-2.5	-2.2	-2.2	-2.2
Patch foraging water rate 24 sec	5.1	7.1	9.5	0.3	3.0	-3.1	-2.8	-2.8	-2.8
Patch foraging water rate 6 sec	1.5	2.1	2.7	-1.6	1.2	-1.6	-1.4	-1.4	-1.4
Seeking ratio, delayed vs. immediate footshock	1.1	1.2	1.8	-1.3	-1.3	0.9	1.0	1.0	1.0
Distance traveled before self-admin	0.3	0.3	0.8	-0.9	-0.7	0.3	0.5	0.5	0.3
Distance traveled after self-admin	0.2	0.2	0.3	-0.4	-0.5	0.5	0.4	0.4	0.5
Extensor digitorum longus weight	2.2	8.8	21.0	4.6	3.5	-2.2	-2.2	-2.2	-2.2
Bone: elastic displacement	0.1	0.1	0.1	-0.2	-0.2	0.3	0.3	0.3	0.2
Bone: elastic work	0.4	0.5	1.2	1.1	-0.3	0.7	0.7	0.7	0.6
Bone: endosteal estimation	0.3	0.7	1.1	1.1	-0.4	0.8	0.8	0.8	0.8
Bone: endosteal perimeter	0.9	1.8	2.2	-0.5	-1.5	1.5	1.5	1.5	1.5
Epididymis fat weight	0.1	0.1	0.2	-0.4	0.2	-0.5	-0.3	-0.4	-0.3
Delta time in closed arm before/after self-admin	4.6	4.5	5.8	-0.1	2.4	-2.3	-2.3	-2.3	-2.3
Delta time in open arm before/after self-admin	0.6	0.6	3.1	1.8	0.0	0.2	0.3	0.3	0.3
Diff in mean of infusions in LGA sessions	0.6	0.6	3.5	-1.9	-0.5	0.0	0.0	0.0	0.0
Delay discount exponential model param	0.2	0.2	0.3	-0.5	0.4	-0.4	-0.4	-0.4	-0.5
Extinction: sum of active levers before priming	1.4	1.4	3.8	-1.9	0.4	-1.0	-1.1	-1.1	-1.1
Active lever presses in extinction session 6	0.4	0.4	0.7	-0.8	-0.9	0.5	0.6	0.5	0.5
Bone: final force	1.2	2.0	6.5	2.5	-0.4	1.2	1.2	1.2	1.1
Bone: final moment	1.2	1.9	6.1	2.5	-0.4	1.2	1.2	1.2	1.1
Food consumed during 24 hour testing period	0.1	0.1	0.7	0.8	0.3	-0.1	-0.1	-0.1	-0.1
Glucose	0.4	0.6	2.8	1.7	0.8	-0.4	-0.2	-0.3	-0.2
Heart weight	0.2	0.2	0.3	-0.2	0.5	-0.5	-0.5	-0.5	-0.5
Delay discount hyperbolic model param	0.3	0.3	0.6	-0.7	0.4	-0.5	-0.5	-0.4	-0.5
Intermittent access intake day 1-15 change	0.4	0.4	2.1	-1.5	0.2	-0.5	-0.2	-0.2	-0.2
Intermittent access intake escalation	1.8	1.8	2.2	-1.5	1.2	-1.5	-1.2	-1.2	-1.2
Intermittent access intake escalation 2	1.4	1.4	3.2	-1.8	0.9	-1.3	-1.0	-1.0	-1.0
Intermitt. access day 1 inactive lever presses	1.5	1.6	1.8	-1.2	1.3	-1.4	-1.3	-1.3	-1.3
Intermitt. access day 15 inactive lever presses	0.9	1.0	3.1	-1.7	0.6	-1.1	-0.8	-0.8	-0.7
Intermitt. access escalation Index	1.7	1.5	1.8	-0.1	-1.3	1.3	1.3	1.3	1.3
Intermittent access day 1 total infusions	0.1	0.2	0.7	0.8	-0.1	0.4	0.2	0.2	0.2
Intermittent access day 15 total infusions	0.2	0.2	0.3	-0.2	0.6	-0.5	-0.4	-0.4	-0.4
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.2	0.0	-0.2	0.3	0.4	0.4	0.5
Intermittent access total infusions	0.1	0.1	0.2	0.4	0.3	-0.2	-0.1	-0.1	-0.1
Intermittent access day 1 locomotion	0.0	0.0	0.0	0.1	0.1	-0.0	-0.2	-0.2	-0.1
Intermittent access day 15 total locomotion	0.3	0.4	2.0	-1.4	0.1	-0.3	-0.2	-0.2	-0.2
Intermittent access total locomotion	0.1	0.1	0.4	-0.6	-0.3	0.2	0.2	0.2	0.2
Intermittent access standard deviation	0.4	0.4	1.6	-1.3	0.4	-0.5	-0.4	-0.4	-0.4
Left kidney weight	0.7	2.1	2.6	0.8	-1.4	1.5	1.6	1.6	1.6
Right kidney weight	0.3	0.9	1.1	-0.8	-1.1	1.0	0.9	0.9	0.9
Cocaine induced anxiety	1.7	1.9	3.0	-0.8	-1.7	1.4	1.4	1.4	1.4
Post-drug Anxiety	2.8	3.1	3.9	0.2	-2.0	1.9	1.9	1.9	1.9
Baseline Anxiety	0.2	0.2	0.3	-0.0	0.4	-0.6	-0.4	-0.4	-0.4
Tail length	0.9	2.9	15.9	-4.0	-0.8	-0.4	-0.4	-0.4	-0.4
Length with tail	0.4	1.3	5.1	-2.3	-1.3	0.5	0.5	0.5	0.5
Length without tail	0.4	1.0	1.1	0.8	-0.9	1.1	1.1	1.1	1.0
Times rat made contact with spout	0.8	0.9	1.3	1.0	1.1	-0.9	-0.9	-0.9	-0.9
Lifetime Intake	0.1	0.2	0.7	0.8	0.1	0.2	0.3	0.3	0.3
Liver weight, left	0.6	1.0	1.7	1.3	1.3	-0.8	-0.9	-0.9	-0.9
Liver weight, right	0.1	0.2	1.1	1.0	0.4	0.1	-0.0	0.0	-0.1
Locomotor activity	1.6	2.5	3.8	-1.9	-2.0	1.4	1.3	1.3	1.4
Locomotor testing distance	0.6	1.0	1.7	-1.3	-1.2	0.9	0.9	0.9	0.9
Locomotor testing rearing	0.1	0.2	0.2	-0.1	0.4	-0.4	-0.5	-0.5	-0.5
Locomotion in novel chamber	0.0	0.0	0.1	0.2	0.3	-0.2	-0.1	-0.1	-0.1
Locomotion in novel chamber post-restriction	0.8	0.9	4.5	-2.1	-0.9	0.2	0.3	0.3	0.4
Fecal boli incidents, locomotor time 1	1.3	1.5	1.9	0.7	1.4	-1.2	-1.2	-1.2	-1.4
Change in fecal boli incidents, locomotor task	2.0	1.9	2.5	-0.3	-1.6	1.5	1.5	1.5	1.5
Time >=10cm from walls, locomotor time 1	1.0	1.0	1.2	1.1	-0.7	1.0	1.0	1.0	1.1
Bouts of movement, locomotor time 1	0.1	0.1	0.7	-0.8	-0.1	-0.1	-0.2	-0.2	-0.1
Total resting periods, locomotor time 1	0.2	0.2	1.3	-1.1	-0.4	0.1	0.1	0.1	0.1
Rest time, locomotor task time 1	0.2	0.3	0.5	-0.4	-0.7	0.5	0.5	0.5	0.5
Distance moved, locomotor task time 1	0.9	1.0	1.2	0.9	-0.7	1.0	1.0	1.0	1.1
Vertical activity count, locomotor time 1	0.3	0.3	0.6	0.7	0.8	-0.4	-0.4	-0.4	-0.4
Time >=10cm from walls, locomotor time 2	0.6	0.6	1.0	0.8	1.0	-0.7	-0.7	-0.7	-0.6
Bouts of movement, locomotor time 2	1.0	1.1	1.5	-0.2	-1.2	1.1	1.2	1.2	1.0
Total resting periods, locomotor time 2	1.3	1.4	1.9	-0.1	-1.4	1.3	1.3	1.3	1.2
Rest time, locomotor task time 2	0.7	0.8	1.0	0.2	-1.0	1.0	1.0	1.0	1.0
Distance moved, locomotor task time 2	0.7	0.8	0.9	-0.2	1.0	-1.0	-1.0	-1.0	-0.9
Vertical activity count, locomotor time 2	1.9	2.0	3.0	0.8	1.7	-1.5	-1.5	-1.5	-1.4
Light reinforcement 1	1.2	2.2	8.6	-2.9	-1.5	0.6	0.8	0.8	0.9
Light reinforcement 2	0.3	0.4	1.9	-1.4	-0.6	0.3	0.3	0.3	0.4
Bone: marrow area	0.3	0.6	1.0	1.0	-0.4	0.8	0.8	0.8	0.8
Bone: maximum diameter	1.5	2.8	3.5	-0.5	-1.9	1.8	1.8	1.8	1.8
Bone: maximum force	1.0	1.7	6.7	2.6	-0.2	1.0	1.0	1.0	0.9
Bone: maximum moment	1.0	1.7	6.3	2.5	-0.2	1.0	1.0	1.0	1.0
Mean time between licks in bursts	0.4	0.6	2.1	-1.4	0.1	-0.6	-0.6	-0.6	-0.5
Mean num. licks in bursts	0.4	0.5	0.8	-0.9	-0.8	0.6	0.6	0.6	0.6
Cd content in liver	0.1	0.1	0.5	0.7	0.2	0.1	-0.1	-0.1	-0.2
Co content in liver	0.5	0.6	2.0	-1.4	0.2	-0.6	-0.7	-0.7	-0.5
Cu content in liver	1.1	1.4	2.2	1.0	-0.8	1.2	1.3	1.3	1.5
Fe content in liver	0.5	0.6	0.8	0.6	0.9	-0.7	-0.8	-0.7	-0.9
K content in liver	1.1	1.1	1.5	-0.5	-1.2	1.1	1.0	1.1	1.1
Mg content in liver	1.6	1.7	2.1	0.1	-1.5	1.4	1.3	1.4	1.4
Mn content in liver	5.4	6.1	7.7	0.0	-2.7	2.6	2.7	2.8	2.7
Na content in liver	0.4	0.4	0.6	0.5	-0.6	0.6	0.6	0.8	0.6
Rb content in liver	1.1	1.4	1.9	0.7	-0.9	1.4	1.3	1.3	1.3
Se content in liver	0.1	0.1	0.1	0.0	-0.3	0.3	0.2	0.2	0.4
Sr content in liver	1.7	1.6	1.8	-1.0	1.1	-1.3	-1.3	-1.3	-1.3
Zn content in liver	2.7	3.0	3.6	-1.8	1.2	-1.7	-1.9	-1.8	-1.9
Bone: minimum diameter	0.7	1.2	1.6	0.7	-0.9	1.2	1.2	1.2	1.2
Time in familiar zone, hab. session 1	1.1	1.0	5.3	-2.3	-0.4	-0.3	-0.3	-0.3	-0.3
Time in novel zone, hab. session 1	1.7	1.7	4.7	2.2	-0.5	1.2	1.2	1.2	1.1
Total zone transitions, hab. session 1	1.6	2.2	3.0	-0.1	-1.7	1.6	1.6	1.6	1.6
Total locomotion distance, hab. session 1	4.0	5.6	7.7	-0.8	-2.8	2.5	2.5	2.5	2.5
Locomotion velocity, hab. session 1	2.8	4.0	5.7	-1.0	-2.4	2.1	2.1	2.1	2.1
Time in familiar zone, hab. session 2	1.6	1.6	7.2	-2.7	0.0	-0.8	-0.8	-0.8	-0.8
Time in novel zone, hab. session 2	2.0	2.0	7.5	2.7	-0.2	1.0	1.0	1.0	1.0
Total zone transitions, hab. session 2	2.2	2.8	3.4	1.2	-1.5	1.8	1.8	1.8	1.8
Total locomotion distance, hab. session 2	1.3	1.8	2.3	-0.1	-1.5	1.4	1.4	1.4	1.4
Locomotion velocity, hab. session 2	2.0	2.7	3.5	0.0	-1.9	1.8	1.8	1.8	1.8
Novel to familiar place preference ratio	1.9	2.0	4.4	2.1	-0.7	1.3	1.3	1.3	1.3
Novelty place preference	1.6	1.7	2.8	1.7	-0.7	1.3	1.3	1.3	1.3
Time in novel zone, NPP test	1.5	1.5	3.5	1.9	-0.6	1.2	1.2	1.2	1.2
Total zone transitions, NPP test	0.6	0.9	1.4	1.2	-0.7	0.9	0.9	0.9	0.9
Total locomotion distance, NPP test	1.2	1.6	1.9	0.7	-1.2	1.4	1.4	1.4	1.4
Locomotion velocity, NPP test	1.1	1.5	1.8	0.4	-1.3	1.3	1.3	1.3	1.3
Intraocular pressure	1.0	1.4	2.2	-0.8	1.0	-1.5	-1.3	-1.3	-1.1
Delta distance traveled before/after self-admin	0.1	0.1	0.2	0.2	-0.1	0.3	0.2	0.1	0.4
Delta ambulatory time before/after self-admin	0.4	0.4	0.6	0.3	-0.5	0.8	0.6	0.6	0.8
Parametrial fat weight	0.1	0.1	0.2	-0.4	0.3	-0.4	-0.4	-0.3	-0.4
Pavlov. Cond. lever latency	1.2	1.5	1.8	-0.2	1.3	-1.3	-1.3	-1.3	-1.3
Pavlov. Cond. magazine entry latency	0.3	0.4	2.5	-1.6	-0.4	-0.1	-0.1	-0.1	-0.1
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	0.4	-0.0	0.2	0.2	0.2	0.2
Pavlov. Cond. index score	0.6	0.8	1.2	-0.5	-1.1	0.9	0.9	0.9	0.9
Pavlov. Cond. latency score	1.2	1.5	2.1	-0.4	-1.5	1.3	1.3	1.3	1.3
Pavlov. Cond. lever contacts	1.9	2.2	2.6	0.5	-1.5	1.6	1.6	1.6	1.6
Pavlov. Cond. magazine entry number	0.1	0.1	0.6	0.8	0.4	-0.1	-0.1	-0.1	-0.2
Pavlov. Cond. intertrial magazine entries	0.7	0.8	1.0	-0.6	0.8	-1.0	-1.0	-1.0	-1.0
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	1.2	-0.6	-1.1	0.9	0.9	0.9	0.9
Pavlov. Cond. response bias	0.2	0.2	0.7	-0.9	-0.6	0.3	0.3	0.3	0.3
Pavlov. Cond. lever latency	0.3	0.4	1.7	1.3	0.7	-0.2	-0.2	-0.2	-0.3
Pavlov. Cond. magazine entry latency	0.6	0.7	2.4	-1.5	-1.0	0.5	0.5	0.5	0.4
Pavlov. Cond. change in total contacts	0.2	0.2	1.2	-1.1	-0.3	-0.0	-0.0	-0.0	0.0
Pavlov. Cond. index score	0.4	0.5	2.7	-1.6	-0.7	0.2	0.2	0.2	0.2
Pavlov. Cond. latency score	0.5	0.6	2.3	-1.5	-0.9	0.4	0.4	0.4	0.4
Pavlov. Cond. lever contacts	0.3	0.4	2.0	-1.4	-0.3	-0.2	-0.2	-0.2	-0.1
Pavlov. Cond. magazine entry number	0.6	0.7	2.6	1.6	1.0	-0.5	-0.5	-0.5	-0.4
Pavlov. Cond. intertrial magazine entries	0.7	0.9	1.3	0.9	1.1	-0.9	-0.9	-0.9	-0.9
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	2.8	-1.7	-0.8	0.3	0.3	0.3	0.3
Pavlov. Cond. response bias	0.5	0.6	3.4	-1.8	-0.4	-0.2	-0.2	-0.2	-0.2
Time in closed arm before self-admin	1.3	1.4	1.7	1.0	-1.1	1.2	1.3	1.3	1.3
Time in closed arm after self-admin	0.0	0.0	0.0	0.2	0.2	-0.2	0.0	0.0	-0.0
Time in open arm before self-admin	0.5	0.6	2.0	-1.4	0.4	-0.5	-0.6	-0.5	-0.6
Time in open arm after self-admin	0.5	0.6	1.2	1.1	0.9	-0.6	-0.7	-0.7	-0.5
Bone: periosteal estimation	1.2	2.4	2.7	1.5	-1.1	1.6	1.6	1.6	1.6
Bone: periosteal perimeter	1.5	2.5	3.1	0.3	-1.5	1.8	1.8	1.8	1.7
Bone: post-yield work	0.1	0.1	0.4	0.6	0.3	-0.0	-0.0	-0.0	-0.0
Progressive ratio test 1 active lever presses	0.3	0.3	1.2	1.1	0.7	-0.3	-0.3	-0.3	-0.3
Progressive ratio test 1 breakpoint	0.3	0.3	1.4	1.2	0.6	-0.2	-0.2	-0.2	-0.2
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.6	-0.8	-0.1	0.1	0.3	0.3	0.3
Progressive ratio test 2 active lever presses	0.0	0.0	0.2	0.5	0.2	-0.1	0.1	0.1	0.1
Progressive ratio test 2 breakpoint	0.3	0.3	0.5	0.2	-0.4	0.5	0.6	0.6	0.7
Progressive ratio test 2 inactive lever presses	0.2	0.2	0.3	0.2	-0.3	0.3	0.5	0.5	0.6
Incentive Sensitization - Responses	0.1	0.1	0.4	-0.6	-0.2	0.0	0.1	0.1	0.2
Incentive Sensitization - Breakpoint	0.2	0.2	0.4	-0.7	-0.4	0.3	0.4	0.4	0.4
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.4	-0.6	-0.1	-0.2	-0.1	-0.1	-0.1
Progressive ratio	0.4	0.5	0.8	0.9	0.9	-0.5	-0.6	-0.5	-0.6
Food seeking constrained by brief footshock	0.2	0.3	1.3	-1.1	-0.6	0.0	0.1	0.1	0.1
Seeking ratio, punishment vs. effort	0.4	0.5	1.9	-1.4	-0.8	0.2	0.3	0.3	0.3
Retroperitoneal fat weight	0.7	2.3	7.4	2.7	1.8	-1.0	-0.9	-0.9	-0.8
Reaction time number correct	1.0	1.5	2.2	0.9	1.5	-1.2	-1.3	-1.3	-1.2
Reaction time mean minus median	0.3	0.5	1.4	-1.2	-0.8	0.4	0.4	0.4	0.4
Reaction time mean minus median AUC	2.2	2.9	4.4	-0.7	-2.1	1.8	1.7	1.7	1.8
Reaction time num false alarms	0.3	0.4	0.8	0.9	0.7	-0.5	-0.5	-0.5	-0.5
Reaction time num false alarms AUC	0.6	0.8	1.3	0.8	1.1	-1.0	-0.8	-0.8	-0.9
Reaction time trials correct on left	1.0	1.5	2.2	0.9	1.5	-1.2	-1.3	-1.3	-1.2
Reaction time trials on left	0.9	1.3	1.9	0.9	1.4	-1.1	-1.2	-1.2	-1.1
Reaction time mean	1.0	1.4	2.3	-0.7	-1.5	1.3	1.2	1.2	1.1
Reaction time mean AUC	0.9	1.1	1.7	-0.3	-1.3	1.2	1.1	1.1	1.1
Median of all reaction times	0.8	1.1	1.7	-0.4	-1.3	1.2	1.1	1.1	1.0
Reaction time omissions	0.1	0.2	0.3	-0.1	-0.4	0.5	0.5	0.5	0.4
Reaction time false alarm rate	0.0	0.1	0.3	0.5	0.0	0.0	0.1	0.1	0.1
Reaction time premature initiation rate	0.8	1.1	3.0	-1.7	0.5	-0.9	-1.0	-1.0	-1.0
Reaction time premature initiations	1.7	2.4	2.8	-1.3	1.3	-1.6	-1.7	-1.7	-1.7
Std. dev. reaction times	0.6	0.8	1.4	-0.7	-1.2	0.9	0.9	0.9	0.9
Reaction time trials completed	0.9	1.3	1.9	0.9	1.4	-1.1	-1.2	-1.2	-1.1
Reaction time trials AUC	1.3	1.8	2.7	0.9	1.6	-1.3	-1.4	-1.4	-1.3
Run reversals in cocaine runway, females	0.9	0.9	1.4	-1.0	-1.2	1.0	0.7	0.8	0.8
Run reversals in cocaine runway, males	1.3	1.2	2.4	-1.6	-1.3	0.9	0.9	0.9	0.8
Latency to leave start box in cocaine runway	1.9	2.1	2.5	1.0	-1.4	1.5	1.6	1.5	1.6
Latency to leave start box in cocaine runway, F	3.7	4.0	4.8	1.3	-2.0	2.2	2.2	2.2	2.1
Latency to leave start box in cocaine runway, M	0.8	0.7	1.0	-0.2	1.0	-1.0	-1.0	-1.0	-0.8
Std. dev. time between licks in bursts	1.3	1.5	1.9	-0.8	-1.4	1.3	1.3	1.3	1.3
Total sessions with >9 infusions	1.5	1.7	2.3	0.3	-1.2	1.3	1.5	1.5	1.5
Short access day 1 total inactive lever presses	0.0	0.0	0.1	-0.3	-0.1	0.0	0.2	0.2	0.2
Short access day 10 total inactive lever presses	0.8	0.9	1.0	-0.9	1.0	-1.0	-0.9	-0.9	-0.9
Short access day 1 total infusions	1.5	1.6	2.2	0.7	-1.0	1.3	1.5	1.5	1.5
Short access day 10 total infusions	0.1	0.1	0.5	0.7	0.2	0.1	0.1	0.1	0.1
Short access total infusions	0.9	1.1	1.4	1.2	-0.6	0.9	1.1	1.1	1.1
Short access day 1 locomotion	0.5	0.5	0.8	-0.2	-0.7	0.9	0.7	0.7	0.8
Short access day 10 total locomotion	0.9	1.1	5.3	-2.3	0.2	-0.5	-0.5	-0.5	-0.5
Short access total locomotion	0.2	0.2	0.4	-0.7	-0.5	0.4	0.4	0.4	0.4
One hour access (0.3 mA shock)	0.1	0.1	0.3	0.6	0.3	-0.2	-0.0	-0.0	-0.0
Compulsive drug intake	0.1	0.1	0.7	0.8	0.0	0.0	0.1	0.1	0.1
One hour access (shock baseline)	0.4	0.4	0.6	-0.4	0.8	-0.7	-0.7	-0.7	-0.7
Social response proportion	0.5	0.6	1.0	-0.6	-1.0	0.7	0.7	0.7	0.7
Social responses	3.0	3.9	8.7	-2.9	-2.5	1.5	1.5	1.5	1.5
Social time	0.4	0.6	1.4	1.2	0.9	-0.5	-0.6	-0.6	-0.6
Soleus weight	1.6	4.7	21.3	4.6	2.1	-0.7	-0.8	-0.8	-0.8
Bone: stiffness	1.0	1.6	8.5	2.9	0.3	0.5	0.5	0.5	0.5
Tibialis anterior weight	0.3	1.2	5.6	2.4	1.0	-0.3	-0.4	-0.4	-0.3
Time to tail flick, vehicle, before self-admin	3.5	3.6	4.6	-1.3	-2.1	1.8	2.0	2.0	2.1
Time to tail flick, vehicle, after self-admin	0.7	0.8	1.0	-0.6	0.7	-0.9	-1.0	-1.0	-1.0
Time to tail flick, test, before self-admin	1.9	1.9	2.6	-0.5	-1.6	1.5	1.4	1.4	1.4
Time to tail flick, test, after self-admin	1.2	1.3	1.7	0.0	-1.2	1.2	1.2	1.2	1.3
Delta time to tail flick, vehicle, before/after SA	3.5	3.4	4.1	1.1	2.0	-1.8	-2.0	-2.0	-2.0
Delta time to tail flick, test, before/after SA	0.5	0.4	0.7	-0.4	0.6	-0.8	-0.7	-0.7	-0.6
Tibia length	0.2	0.5	2.7	-1.6	-0.4	-0.2	-0.2	-0.2	-0.1
Ambulatory time before self-admin	0.1	0.1	0.4	-0.6	-0.3	0.0	0.2	0.2	0.2
Ambulatory time after self-admin	0.1	0.1	0.2	-0.2	-0.3	0.3	0.3	0.3	0.4
Bone: tissue strength	0.8	0.8	4.4	2.1	0.4	0.2	0.2	0.2	0.3
Total heroin consumption	0.8	0.9	2.1	-1.5	-1.2	0.7	0.7	0.7	0.7
Bone: trabecular number	2.1	3.2	4.3	-0.2	-2.1	1.9	1.9	1.9	1.9
Bone: trabecular spacing	4.5	5.8	7.0	-0.5	2.6	-2.6	-2.6	-2.6	-2.6
Bone: trabecular thickness	8.4	10.1	12.1	1.2	-3.2	3.5	3.5	3.5	3.5
Bone: trabecular tissue density	2.3	3.2	6.8	2.6	2.2	-1.4	-1.4	-1.4	-1.3
Water consumed over 24 hours	0.9	1.1	1.3	1.1	-0.7	1.1	1.1	1.1	1.1
Number of responses in last shaping day	0.5	0.5	2.7	-1.7	-0.4	0.2	0.2	0.2	0.2