Hub : Genes

Nab1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Nab1 0.16 0.11 1.5e-05 0.04 0.05 0.05 0.05 4.0e-03 9.1e-04 1.8e-03 1.0e-03
2 LHb gene expression Nab1 0.33 0.18 1.2e-04 0.01 -0 -0.01 -0.01 1.5e-01 4.4e-01 8.0e-01 6.3e-01
3 NAcc gene expression Nab1 0.1 0.05 4.4e-16 0.13 0.12 0.11 0.12 1.7e-14 6.8e-14 4.8e-13 1.7e-13
4 OFC gene expression Nab1 0.34 0.16 1.6e-05 0.14 0.11 0.11 0.12 4.4e-04 1.3e-03 1.6e-03 7.6e-04
5 Adipose mRNA stability Nab1 0.08 0.05 2.9e-09 0.06 0.05 0.06 0.06 8.6e-07 1.6e-06 9.1e-07 3.0e-07
6 pVTA gene expression Nab1 0.28 0.14 1.4e-11 0.22 0.2 0.16 0.2 5.9e-10 4.1e-09 1.3e-07 3.1e-09
7 Brain gene expression Nab1 0.18 0.1 0.0e+00 0.19 0.18 0.18 0.19 4.3e-17 6.2e-17 5.8e-17 1.0e-17
8 PL gene expression Nab1 0.08 0.05 3.1e-09 0.08 0.08 0.06 0.07 4.6e-09 7.7e-09 1.7e-07 1.4e-08
9 OFC alternative polyA XM_039084185.1 0.22 0.15 3.3e-03 0 0.01 -0.01 -0 3.0e-01 1.6e-01 9.6e-01 4.2e-01
10 OFC alternative polyA NM_022856.5 0.23 0.18 4.7e-03 -0 0.02 -0.01 -0.01 4.5e-01 1.4e-01 6.2e-01 5.8e-01
11 OFC alternative polyA NM_022856.5 0.23 0.17 4.8e-03 -0 0.01 -0.01 -0.01 4.1e-01 1.4e-01 5.0e-01 6.2e-01
12 Adipose gene expression Nab1 0.25 0.09 0.0e+00 0.23 0.24 0.24 0.23 3.7e-25 6.6e-26 7.3e-26 1.9e-25
13 Eye gene expression Nab1 0.43 0.24 7.5e-03 0.05 0.17 0.14 0.15 6.5e-02 1.6e-03 3.3e-03 2.9e-03
14 OFC isoform ratio NM_022856.5 0.27 0.18 2.8e-03 -0 0 0.02 -0 3.8e-01 2.9e-01 9.5e-02 3.6e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density2.44.16.7-2.22.02.02.0-2.02.0-2.02.0-2.22.22.2-1.6-1.3-2.6
Area under the delay curve0.00.00.2-0.10.00.00.0-0.00.00.0-0.10.1-0.2-0.20.10.00.4
BMI with tail6.119.922.24.6-4.7-4.7-4.74.7-4.54.6-4.44.6-4.6-4.64.44.22.9
BMI without tail1.73.54.91.6-1.8-1.8-1.81.8-1.81.8-1.71.9-1.9-1.91.91.92.2
Body weight0.10.55.00.5-0.2-0.2-0.20.2-0.30.2-0.20.5-0.5-0.4-0.0-0.22.2
Weight adjusted by age0.50.61.3-0.20.90.90.9-0.90.8-0.70.6-0.80.80.8-1.1-1.1-0.1
Bone surface0.91.62.8-0.91.21.21.2-1.21.2-1.21.2-1.41.51.5-1.3-1.1-1.7
Bone volume2.44.15.2-1.92.02.02.0-2.02.0-2.02.0-2.22.22.2-1.9-1.7-2.3
Breakpoint value in progressive ratio session0.91.03.0-1.10.90.90.9-0.91.0-1.00.9-0.70.70.7-0.9-1.01.7
Number of licking bursts0.30.30.8-0.1-0.5-0.5-0.50.5-0.50.5-0.50.5-0.5-0.60.90.9-0.3
Context. condit. distance diff. score1.51.82.80.6-1.3-1.3-1.31.3-1.31.3-1.21.5-1.6-1.61.71.60.4
Locomotion velocity, session 10.10.10.30.1-0.3-0.3-0.30.2-0.20.2-0.10.4-0.4-0.40.20.10.5
Locomotion distance, session 10.20.30.40.6-0.6-0.6-0.60.5-0.50.5-0.30.6-0.6-0.60.40.30.5
Locomotion velocity, session 21.41.72.71.7-1.4-1.4-1.41.4-1.41.4-1.21.3-1.3-1.31.11.00.7
Locomotion distance, session 20.50.71.41.2-0.9-0.9-0.90.9-0.90.9-0.60.8-0.8-0.80.50.50.8
Locomotion velocity, session 30.20.20.30.4-0.5-0.5-0.50.5-0.50.5-0.40.5-0.5-0.50.50.50.1
Locomotion distance, session 30.50.61.00.5-0.8-0.8-0.80.8-0.70.8-0.70.7-0.7-0.70.91.0-0.7
Stereotopy head waving bouts, day 30.60.72.10.9-0.8-0.8-0.80.8-0.70.8-0.80.9-0.9-0.80.70.61.5
Stereotopy head waving duration, day 30.10.10.90.2-0.2-0.2-0.20.2-0.20.2-0.20.3-0.4-0.30.20.11.0
Locomotion velocity, session 70.10.10.50.7-0.2-0.2-0.20.2-0.20.2-0.10.2-0.2-0.1-0.2-0.30.2
Locomotion distance, session 70.10.20.50.7-0.3-0.3-0.30.3-0.40.3-0.30.4-0.4-0.4-0.1-0.20.7
Stereotopy head waving bouts, day 70.10.10.3-0.60.40.40.4-0.40.4-0.40.3-0.30.30.3-0.3-0.3-0.1
Stereotopy head waving duration, day 70.60.81.0-1.00.90.90.9-0.90.9-0.90.9-0.90.90.8-0.8-0.8-0.5
Locomotion velocity, session 80.40.50.90.5-0.7-0.7-0.70.7-0.70.7-0.70.7-0.7-0.70.91.0-0.8
Locomotion distance, session 81.52.22.71.3-1.6-1.6-1.61.6-1.61.6-1.31.6-1.6-1.61.61.60.0
Degree of sensitization distance0.50.51.4-0.00.60.60.6-0.60.5-0.60.6-0.50.50.5-1.0-1.21.1
Degree of sensitization stereotypy0.20.21.0-0.70.40.40.4-0.50.5-0.50.3-0.40.40.4-0.2-0.2-1.0
Conditioned locomotion0.10.11.2-0.20.10.10.1-0.10.2-0.10.20.1-0.1-0.1-0.2-0.31.1
Cocaine response after cond. corrected0.20.22.40.40.10.10.1-0.10.1-0.00.20.0-0.0-0.0-0.5-0.71.5
Cocaine response after cond. not corrected1.11.22.7-0.41.01.01.0-1.01.1-1.01.1-0.90.91.0-1.5-1.71.3
Cocaine response before conditioning1.11.31.6-0.91.21.21.2-1.21.2-1.11.2-1.21.21.3-1.3-1.2-0.4
Saline control response0.10.20.50.0-0.4-0.4-0.40.4-0.40.4-0.40.3-0.3-0.30.60.7-0.6
Bone: connectivity density0.40.62.9-0.70.60.60.6-0.60.6-0.60.6-0.80.80.8-0.4-0.2-1.7
Bone: cortical apparent density6.99.110.93.3-3.1-3.1-3.13.1-3.03.1-3.23.2-3.2-3.12.82.52.0
Bone: cortical area0.00.10.30.40.00.00.0-0.00.1-0.10.0-0.10.10.1-0.4-0.50.5
Bone: cortical porosity1.82.03.1-1.51.41.41.4-1.41.3-1.31.6-1.61.61.6-1.1-0.9-1.8
Bone: cortical porosity2.72.93.9-1.71.61.61.6-1.61.6-1.62.0-1.91.91.9-1.5-1.2-1.9
Bone: cortical thickness1.52.43.01.7-1.6-1.6-1.61.6-1.51.6-1.71.6-1.6-1.61.41.30.9
Bone: cortical thickness0.00.00.10.10.10.10.1-0.10.2-0.20.1-0.20.20.2-0.2-0.20.0
Bone: cortical tissue density6.88.910.83.3-3.1-3.1-3.13.1-3.03.0-3.23.1-3.1-3.12.72.52.0
Condit. Reinf. active minus inactive responses4.75.36.4-2.52.52.52.5-2.52.5-2.42.4-2.12.12.1-2.3-2.4-0.4
Condit. Reinf. active-inactive response ratio2.62.83.6-1.91.81.81.8-1.81.8-1.81.7-1.51.51.5-1.7-1.8-0.0
Condit. Reinf. active responses4.15.06.4-2.32.42.42.4-2.42.4-2.42.3-2.12.02.1-2.4-2.5-0.2
Condit. Reinf. inactive responses0.20.20.6-0.10.30.30.3-0.40.3-0.40.4-0.20.20.2-0.6-0.70.8
Incentive salience index mean3.44.25.6-2.42.22.22.2-2.22.2-2.22.1-2.01.91.9-1.9-1.9-0.9
Condit. Reinf. lever presses0.50.61.5-1.20.90.90.9-0.90.9-0.80.8-0.70.70.7-0.5-0.5-0.5
Condit. Reinf. active minus inactive responses4.04.95.6-2.22.32.32.3-2.32.4-2.42.2-2.32.22.2-2.3-2.30.3
Condit. Reinf. active-inactive response ratio3.23.34.0-2.01.91.91.9-1.92.0-1.91.7-1.91.91.9-1.7-1.7-0.6
Condit. Reinf. active responses1.11.62.1-1.11.31.31.3-1.31.3-1.41.2-1.21.21.2-1.4-1.41.1
Condit. Reinf. inactive responses0.10.11.00.3-0.0-0.0-0.00.0-0.1-0.00.10.0-0.0-0.0-0.2-0.21.0
Condit. Reinf. lever presses0.10.10.3-0.20.30.30.3-0.30.4-0.30.3-0.40.40.4-0.4-0.30.5
Condit. Reinf. lever reinforcers received1.01.52.1-0.91.21.21.2-1.21.2-1.31.1-1.11.11.1-1.4-1.51.1
Conditioned reinforcement - actives0.60.60.7-0.70.80.80.8-0.80.8-0.80.8-0.80.70.8-0.8-0.80.5
Conditioned reinforcement - inactives1.21.41.9-1.11.21.21.2-1.21.4-1.21.0-1.21.21.2-1.2-1.20.2
Conditioned locomotion1.31.53.51.9-1.2-1.2-1.21.2-1.21.3-1.51.2-1.1-1.10.90.91.3
Patch foraging indifference point 0 sec3.96.37.62.8-2.7-2.7-2.72.7-2.72.7-2.62.3-2.2-2.22.52.7-0.2
Patch foraging indifference point AUC0.30.41.70.9-0.5-0.5-0.50.5-0.50.5-0.70.2-0.1-0.10.40.5-1.3
Delay disc. indifference point, 0s delay0.10.10.9-0.10.10.10.1-0.10.1-0.1-0.0-0.20.20.20.00.1-0.9
Delay disc. indifference point, 16s delay0.40.40.7-0.80.80.80.8-0.80.8-0.70.6-0.50.50.5-0.6-0.7-0.0
Delay disc. indifference point, 2s delay0.00.00.10.00.00.00.0-0.00.00.0-0.1-0.10.10.10.10.10.2
Delay disc. indifference point, 24s delay0.10.10.4-0.0-0.2-0.2-0.20.2-0.20.2-0.30.5-0.5-0.50.50.30.6
Delay disc. indifference point, 4s delay0.40.40.60.7-0.6-0.6-0.60.6-0.60.7-0.80.7-0.7-0.70.70.6-0.1
Delay disc. indifference point, 8s delay0.40.40.8-0.60.70.70.7-0.70.7-0.60.6-0.40.40.4-0.6-0.70.9
Indifference point function ln k1.01.32.10.6-1.1-1.1-1.11.1-1.21.2-1.11.3-1.3-1.31.41.40.3
Indifference point function log k1.01.32.10.6-1.1-1.1-1.11.1-1.21.2-1.11.3-1.3-1.31.41.40.3
Patch foraging total patch changes 0 sec3.86.27.62.7-2.7-2.7-2.72.7-2.72.7-2.62.2-2.1-2.22.52.8-0.6
Patch foraging total patch changes 12 sec0.50.71.41.2-1.0-1.0-1.01.0-0.80.9-0.80.6-0.5-0.50.70.9-0.2
Patch foraging total patch changes 18 sec2.02.53.31.8-1.7-1.7-1.71.7-1.61.6-1.71.3-1.2-1.21.61.8-1.0
Patch foraging total patch changes 24 sec1.21.42.01.4-1.4-1.4-1.41.4-1.21.3-1.20.9-0.8-0.81.21.4-0.5
Patch foraging total patch changes 6 sec3.45.06.52.6-2.5-2.5-2.52.5-2.32.4-2.42.0-1.9-1.92.32.5-0.5
Patch foraging time to switch 0 sec1.01.52.1-1.41.31.31.3-1.31.4-1.21.3-1.11.11.1-1.2-1.21.1
Patch foraging water rate 0 sec0.81.42.51.3-1.2-1.2-1.21.2-1.61.2-1.21.2-1.2-1.21.11.1-0.2
Patch foraging water rate 12 sec0.40.60.90.5-0.8-0.8-0.80.8-0.90.8-0.70.8-0.8-0.80.90.9-0.6
Patch foraging water rate 18 sec0.10.10.2-0.2-0.2-0.2-0.20.2-0.40.2-0.10.4-0.4-0.40.40.40.1
Patch foraging water rate 24 sec0.10.10.9-0.10.20.20.2-0.2-0.1-0.10.20.1-0.1-0.1-0.2-0.40.9
Patch foraging water rate 6 sec1.31.92.71.0-1.4-1.4-1.41.4-1.51.4-1.31.4-1.5-1.51.61.6-0.5
Seeking ratio, delayed vs. immediate footshock2.83.23.4-1.71.81.81.8-1.81.8-1.81.8-1.81.81.8-1.8-1.7-1.7
Distance traveled before self-admin7.07.48.5-2.42.82.82.8-2.82.7-2.82.7-2.92.92.9-2.8-2.7-2.1
Distance traveled after self-admin1.71.82.5-1.21.31.31.3-1.31.3-1.51.5-1.41.41.4-1.6-1.6-0.3
Extensor digitorum longus weight3.815.127.35.2-4.0-4.0-4.04.0-4.14.0-3.94.0-4.0-3.92.82.43.3
Bone: elastic displacement0.10.10.8-0.50.00.00.0-0.00.0-0.00.0-0.10.10.10.40.5-0.9
Bone: elastic work1.62.12.4-1.51.51.51.5-1.51.5-1.51.6-1.51.61.5-1.4-1.3-0.9
Bone: endosteal estimation4.39.411.7-2.53.13.13.1-3.13.1-3.13.3-3.33.33.3-3.4-3.3-1.2
Bone: endosteal perimeter1.83.75.2-1.62.02.02.0-2.02.0-2.02.0-2.01.92.0-2.2-2.30.1
Epididymis fat weight0.40.91.8-0.70.90.90.9-0.90.9-1.11.0-0.70.70.8-1.2-1.30.9
Delta time in closed arm before/after self-admin1.11.02.61.2-1.0-1.0-1.01.0-0.91.0-1.00.9-0.9-0.90.80.81.6
Delta time in open arm before/after self-admin4.54.47.7-2.22.12.12.1-2.12.0-2.12.1-2.12.12.1-1.7-1.6-2.8
Diff in mean of infusions in LGA sessions1.51.72.2-1.51.41.41.4-1.41.4-1.41.2-1.31.21.2-1.2-1.21.1
Delay discount exponential model param0.00.00.10.10.00.00.0-0.00.0-0.10.2-0.20.20.2-0.2-0.1-0.3
Extinction: sum of active levers before priming1.91.92.3-1.41.41.41.4-1.41.4-1.51.5-1.31.31.3-1.4-1.5-0.4
Active lever presses in extinction session 60.40.41.5-0.90.60.60.6-0.60.6-0.60.6-0.50.50.5-0.4-0.5-1.2
Bone: final force0.91.42.8-0.51.21.21.2-1.21.2-1.21.2-1.21.21.3-1.6-1.70.3
Bone: final moment0.40.71.6-0.20.80.80.8-0.80.8-0.80.8-0.90.90.9-1.2-1.30.3
Food consumed during 24 hour testing period0.60.81.0-0.40.80.80.8-0.80.8-0.80.8-0.91.01.0-1.0-1.0-1.0
Glucose0.81.22.20.5-1.0-1.0-1.01.0-1.01.0-0.91.1-1.1-1.21.31.31.5
Heart weight0.71.03.8-0.70.90.90.9-0.90.9-0.90.9-0.90.90.9-0.8-0.8-1.9
Delay discount hyperbolic model param0.10.10.1-0.10.20.20.2-0.20.2-0.20.3-0.30.30.3-0.3-0.2-0.3
Intermittent access intake day 1-15 change1.01.01.20.9-1.1-1.1-1.11.1-0.81.0-1.11.0-1.0-1.01.11.0-0.0
Intermittent access intake escalation0.40.40.50.5-0.7-0.7-0.70.7-0.40.6-0.70.7-0.7-0.70.70.60.2
Intermittent access intake escalation 20.10.10.20.0-0.3-0.3-0.30.3-0.10.2-0.30.4-0.4-0.40.40.40.0
Intermitt. access day 1 inactive lever presses0.10.10.40.3-0.3-0.3-0.30.3-0.50.4-0.20.2-0.2-0.20.30.40.6
Intermitt. access day 15 inactive lever presses0.91.01.4-1.21.11.11.1-1.11.0-1.11.1-1.01.01.0-0.9-0.9-0.1
Intermitt. access escalation Index1.31.23.50.7-1.0-1.0-1.01.0-1.00.9-0.91.2-1.2-1.20.90.81.9
Intermittent access day 1 total infusions0.40.51.0-1.00.80.80.8-0.80.8-0.70.4-0.60.60.6-0.4-0.30.9
Intermittent access day 15 total infusions0.20.20.8-0.1-0.3-0.3-0.30.3-0.10.3-0.60.5-0.5-0.50.60.60.9
Intermittent access terminal intake (last 3 days)0.40.50.90.3-0.6-0.6-0.60.6-0.30.6-0.90.7-0.7-0.70.90.90.6
Intermittent access total infusions0.10.10.3-0.50.30.30.3-0.30.5-0.2-0.1-0.10.10.10.10.20.5
Intermittent access day 1 locomotion0.10.10.3-0.20.30.30.3-0.30.4-0.2-0.1-0.20.20.2-0.1-0.00.6
Intermittent access day 15 total locomotion0.10.10.6-0.10.40.40.4-0.40.3-0.10.0-0.10.10.1-0.2-0.20.8
Intermittent access total locomotion0.10.10.50.2-0.2-0.2-0.20.2-0.10.4-0.50.3-0.4-0.40.40.40.7
Intermittent access standard deviation0.20.20.40.5-0.5-0.5-0.50.5-0.50.6-0.60.4-0.4-0.40.50.6-0.5
Left kidney weight0.00.10.60.10.20.20.2-0.3-0.0-0.20.3-0.20.10.2-0.5-0.60.8
Right kidney weight0.10.21.11.0-0.4-0.4-0.40.4-0.50.5-0.30.4-0.5-0.4-0.1-0.2-0.5
Cocaine induced anxiety3.84.45.92.4-2.1-2.1-2.12.1-2.12.1-2.22.2-2.2-2.21.61.42.4
Post-drug Anxiety2.12.35.71.6-1.4-1.4-1.41.4-1.41.4-1.41.6-1.7-1.61.10.92.4
Baseline Anxiety2.42.64.2-2.11.71.71.7-1.71.7-1.71.7-1.61.61.6-1.3-1.2-1.1
Tail length4.312.915.1-3.63.93.93.9-3.93.7-3.83.8-3.53.53.5-3.8-3.80.3
Length with tail4.416.220.5-3.64.34.34.3-4.34.1-4.24.0-4.04.04.0-4.4-4.5-0.5
Length without tail0.30.72.1-0.10.80.80.8-0.90.7-0.80.7-0.80.80.8-1.3-1.5-0.3
Times rat made contact with spout0.10.20.8-0.4-0.2-0.2-0.20.2-0.30.20.10.2-0.2-0.20.60.7-0.9
Lifetime Intake0.10.10.7-0.10.10.10.1-0.10.3-0.0-0.40.1-0.1-0.10.30.30.8
Liver weight, left0.10.20.90.50.30.30.3-0.30.1-0.30.3-0.50.60.6-0.7-0.6-0.9
Liver weight, right0.10.10.40.20.20.20.2-0.20.4-0.40.3-0.30.30.4-0.5-0.6-0.1
Locomotor activity0.10.11.10.3-0.3-0.3-0.30.3-0.30.3-0.20.2-0.2-0.20.20.21.1
Locomotor testing distance0.00.10.4-0.2-0.1-0.1-0.10.10.10.10.1-0.20.20.20.20.4-0.6
Locomotor testing rearing0.60.91.30.4-0.9-0.9-0.90.9-0.80.9-0.90.9-1.0-1.01.11.10.9
Locomotion in novel chamber0.81.03.11.8-1.0-1.0-1.01.0-1.11.1-1.11.0-1.0-0.90.60.5-0.2
Locomotion in novel chamber post-restriction0.40.51.51.2-0.7-0.7-0.70.7-0.80.7-0.70.7-0.7-0.70.40.3-0.6
Fecal boli incidents, locomotor time 10.10.10.30.2-0.3-0.3-0.30.3-0.30.3-0.30.2-0.2-0.20.40.4-0.6
Change in fecal boli incidents, locomotor task0.10.10.4-0.1-0.2-0.2-0.20.2-0.20.1-0.20.2-0.3-0.30.30.20.6
Time >=10cm from walls, locomotor time 10.00.00.30.50.00.00.0-0.00.00.10.00.1-0.1-0.0-0.3-0.40.1
Bouts of movement, locomotor time 11.21.31.41.1-1.2-1.2-1.21.2-1.21.2-1.21.1-1.1-1.11.11.10.8
Total resting periods, locomotor time 11.51.72.01.4-1.4-1.4-1.41.4-1.41.4-1.41.3-1.3-1.31.31.20.6
Rest time, locomotor task time 10.70.81.30.7-0.9-0.9-0.90.9-0.90.9-0.90.9-0.8-0.91.11.10.3
Distance moved, locomotor task time 10.20.20.8-0.40.40.40.4-0.40.5-0.40.5-0.10.10.1-0.5-0.70.9
Vertical activity count, locomotor time 10.00.00.1-0.00.10.10.1-0.10.1-0.10.10.0-0.0-0.0-0.2-0.30.3
Time >=10cm from walls, locomotor time 21.61.74.3-1.41.21.21.2-1.21.2-1.31.2-1.31.21.2-1.1-1.0-2.1
Bouts of movement, locomotor time 23.53.84.62.0-2.0-2.0-2.02.0-2.01.9-2.02.1-2.1-2.11.81.61.5
Total resting periods, locomotor time 23.63.84.52.1-2.0-2.0-2.02.0-2.12.0-2.12.1-2.1-2.11.91.81.0
Rest time, locomotor task time 21.41.62.51.1-1.3-1.3-1.31.3-1.31.3-1.31.1-1.1-1.11.41.6-0.8
Distance moved, locomotor task time 20.80.91.7-0.90.90.90.9-0.91.0-0.91.0-0.80.70.7-1.1-1.21.3
Vertical activity count, locomotor time 20.00.10.3-0.0-0.1-0.1-0.10.1-0.10.1-0.10.3-0.3-0.30.1-0.00.5
Light reinforcement 13.87.010.63.3-2.9-2.9-2.92.9-2.72.8-2.62.6-2.6-2.62.32.21.4
Light reinforcement 20.60.91.41.2-1.0-1.0-1.01.0-0.91.0-0.90.8-0.8-0.80.80.9-0.5
Bone: marrow area4.18.811.0-2.43.03.03.0-3.03.0-3.03.2-3.23.23.2-3.3-3.2-1.2
Bone: maximum diameter0.00.00.20.10.10.10.1-0.10.1-0.10.1-0.10.10.1-0.3-0.40.4
Bone: maximum force2.23.85.8-1.11.91.91.9-1.92.0-1.92.0-2.12.12.2-2.4-2.4-0.5
Bone: maximum moment1.42.43.8-0.81.51.51.5-1.51.5-1.51.6-1.71.71.8-1.9-1.9-0.5
Mean time between licks in bursts1.11.53.31.8-1.3-1.3-1.31.3-1.21.4-1.41.1-1.1-1.10.90.90.1
Mean num. licks in bursts0.00.00.10.10.10.10.1-0.10.0-0.10.2-0.20.20.2-0.3-0.2-0.2
Cd content in liver0.91.01.7-0.61.01.01.0-1.01.0-1.01.0-1.01.01.0-1.2-1.30.1
Co content in liver0.20.20.8-0.90.50.50.5-0.50.5-0.50.5-0.30.30.3-0.1-0.20.0
Cu content in liver1.72.13.2-1.81.51.51.5-1.51.7-1.51.5-1.41.41.4-1.3-1.3-0.3
Fe content in liver3.13.74.8-2.22.02.02.0-2.02.0-2.02.0-1.91.91.9-1.7-1.7-1.4
K content in liver1.01.01.91.4-1.1-1.1-1.11.1-1.01.1-1.00.7-0.7-0.70.91.0-0.8
Mg content in liver1.01.01.31.1-1.1-1.1-1.11.1-1.01.1-1.10.8-0.8-0.81.01.1-0.4
Mn content in liver0.50.61.40.5-0.8-0.8-0.80.8-0.80.8-0.80.6-0.5-0.61.01.2-0.7
Na content in liver0.10.20.50.4-0.4-0.4-0.40.4-0.30.4-0.40.2-0.1-0.20.40.5-0.7
Rb content in liver0.70.93.41.3-0.8-0.8-0.80.8-0.90.8-0.71.0-1.0-0.90.40.21.8
Se content in liver0.10.10.10.4-0.3-0.3-0.30.3-0.30.3-0.20.2-0.1-0.10.20.3-0.3
Sr content in liver0.30.20.60.3-0.4-0.4-0.40.4-0.40.4-0.40.6-0.6-0.60.50.40.7
Zn content in liver0.80.91.21.0-1.0-1.0-1.01.0-0.91.0-1.11.0-1.0-1.00.80.81.1
Bone: minimum diameter0.61.22.1-0.41.11.11.1-1.11.0-1.11.0-1.21.21.2-1.5-1.4-0.2
Time in familiar zone, hab. session 10.70.60.90.5-0.8-0.8-0.80.8-0.70.8-0.90.9-0.9-0.90.90.80.6
Time in novel zone, hab. session 13.83.74.8-2.22.02.02.0-2.02.0-2.02.0-2.02.02.0-1.7-1.6-1.1
Total zone transitions, hab. session 10.20.30.6-0.10.50.50.5-0.50.5-0.50.8-0.60.60.6-0.8-0.8-0.1
Total locomotion distance, hab. session 11.31.93.5-0.61.31.31.3-1.41.3-1.41.5-1.41.41.5-1.8-1.9-0.0
Locomotion velocity, hab. session 10.30.41.20.20.50.50.5-0.60.5-0.60.7-0.70.70.7-1.1-1.10.1
Time in familiar zone, hab. session 20.00.00.1-0.2-0.0-0.0-0.00.0-0.00.0-0.00.0-0.0-0.00.10.2-0.3
Time in novel zone, hab. session 20.00.00.2-0.1-0.1-0.1-0.10.1-0.10.1-0.00.1-0.2-0.20.20.20.4
Total zone transitions, hab. session 20.00.00.20.1-0.2-0.2-0.20.2-0.20.20.00.2-0.2-0.20.20.20.4
Total locomotion distance, hab. session 20.50.61.2-0.50.70.70.7-0.80.8-0.81.0-0.70.70.7-1.0-1.10.9
Locomotion velocity, hab. session 20.40.51.1-0.30.60.60.6-0.70.6-0.70.9-0.60.60.6-0.9-1.01.0
Novel to familiar place preference ratio1.51.62.0-1.41.31.31.3-1.31.3-1.31.3-1.41.41.3-1.1-1.0-0.5
Novelty place preference1.01.01.6-1.31.01.01.0-1.01.0-1.01.1-1.11.11.1-0.8-0.7-0.5
Time in novel zone, NPP test1.11.21.9-1.41.11.11.1-1.11.1-1.11.2-1.11.11.1-0.8-0.7-0.6
Total zone transitions, NPP test0.40.61.50.8-0.8-0.8-0.80.7-0.70.7-0.40.9-0.9-0.90.60.41.2
Total locomotion distance, NPP test0.20.30.5-0.10.40.40.4-0.50.5-0.50.7-0.60.60.6-0.7-0.7-0.5
Locomotion velocity, NPP test0.00.10.30.3-0.0-0.0-0.0-0.00.1-0.00.3-0.20.20.2-0.3-0.3-0.6
Intraocular pressure0.50.73.90.4-0.6-0.6-0.60.6-0.70.6-0.70.7-0.7-0.70.70.72.0
Delta distance traveled before/after self-admin1.11.23.70.8-1.0-1.0-1.01.0-1.11.0-0.81.1-1.1-1.10.80.71.9
Delta ambulatory time before/after self-admin1.41.54.71.0-1.2-1.2-1.21.2-1.21.1-0.91.3-1.3-1.30.90.82.2
Parametrial fat weight0.10.11.00.1-0.2-0.2-0.20.2-0.20.1-0.10.3-0.4-0.40.10.01.0
Pavlov. Cond. lever latency2.12.74.32.1-1.7-1.7-1.71.7-1.71.7-1.81.6-1.6-1.61.31.21.2
Pavlov. Cond. magazine entry latency2.53.34.3-2.11.91.91.9-1.91.9-1.91.9-1.81.81.8-1.7-1.7-0.7
Pavlov. Cond. change in total contacts1.61.72.8-1.71.41.41.4-1.41.4-1.41.4-1.21.21.2-1.2-1.2-0.1
Pavlov. Cond. index score1.92.44.4-2.11.61.61.6-1.61.6-1.61.6-1.51.51.5-1.2-1.1-1.1
Pavlov. Cond. latency score2.12.74.6-2.11.71.71.7-1.71.7-1.71.8-1.61.61.6-1.3-1.2-1.2
Pavlov. Cond. lever contacts0.80.92.2-1.51.01.01.0-0.90.9-0.91.1-0.90.90.8-0.5-0.4-1.2
Pavlov. Cond. magazine entry number3.94.97.22.7-2.3-2.3-2.32.3-2.42.3-2.32.2-2.2-2.12.01.91.1
Pavlov. Cond. intertrial magazine entries0.20.21.70.3-0.2-0.2-0.20.2-0.10.2-0.30.4-0.4-0.40.1-0.01.3
Pavlov. Cond. lever-magazine prob. diff.1.51.93.4-1.91.51.51.5-1.41.5-1.41.4-1.41.31.3-1.1-1.0-1.0
Pavlov. Cond. response bias1.62.03.7-1.91.51.51.5-1.51.5-1.51.4-1.41.31.3-1.0-1.0-1.1
Pavlov. Cond. lever latency0.30.40.60.6-0.7-0.7-0.70.7-0.70.6-0.60.8-0.8-0.80.70.60.3
Pavlov. Cond. magazine entry latency0.40.50.6-0.50.70.70.7-0.70.7-0.60.6-0.80.80.8-0.7-0.6-0.7
Pavlov. Cond. change in total contacts1.11.62.1-1.21.31.31.3-1.31.3-1.21.1-1.41.51.4-1.2-1.0-0.8
Pavlov. Cond. index score0.91.11.5-0.81.11.11.1-1.11.1-1.00.9-1.21.21.2-1.1-1.0-0.8
Pavlov. Cond. latency score0.91.11.5-0.81.01.01.0-1.01.1-1.00.9-1.21.21.2-1.1-1.0-0.8
Pavlov. Cond. lever contacts0.60.91.3-0.80.90.90.9-0.90.9-0.90.9-1.11.11.1-0.9-0.7-0.8
Pavlov. Cond. magazine entry number1.01.22.21.0-1.1-1.1-1.11.1-1.11.0-0.91.2-1.2-1.21.00.91.5
Pavlov. Cond. intertrial magazine entries1.01.31.61.0-1.2-1.2-1.21.2-1.21.0-1.11.3-1.3-1.31.11.01.0
Pavlov. Cond. lever-magazine prob. diff.0.50.60.9-0.50.80.80.8-0.80.8-0.70.6-0.91.01.0-0.8-0.7-0.6
Pavlov. Cond. response bias1.31.72.5-1.11.31.31.3-1.31.3-1.31.2-1.51.61.6-1.4-1.2-1.0
Time in closed arm before self-admin3.03.43.9-1.81.91.91.9-1.91.9-1.91.8-2.02.02.0-1.7-1.5-1.8
Time in closed arm after self-admin0.20.30.9-0.20.30.30.3-0.30.5-0.50.5-0.50.60.6-0.5-0.50.9
Time in open arm before self-admin3.74.013.11.9-1.8-1.8-1.81.8-1.71.8-1.92.1-2.1-2.11.51.23.6
Time in open arm after self-admin2.73.03.5-1.91.91.91.9-1.91.8-1.81.8-1.71.71.7-1.6-1.6-0.7
Bone: periosteal estimation2.24.66.4-1.52.22.22.2-2.22.2-2.22.2-2.32.32.3-2.5-2.5-0.6
Bone: periosteal perimeter0.91.62.4-0.91.31.31.3-1.31.3-1.31.3-1.31.31.3-1.5-1.50.1
Bone: post-yield work1.62.23.0-1.11.51.51.5-1.51.5-1.51.5-1.51.51.6-1.7-1.7-0.1
Progressive ratio test 1 active lever presses0.10.11.10.3-0.2-0.2-0.20.2-0.10.3-0.30.2-0.2-0.20.20.11.1
Progressive ratio test 1 breakpoint0.10.10.90.4-0.2-0.2-0.20.2-0.20.3-0.40.2-0.2-0.20.20.20.9
Progressive ratio test 1 inactive lever presses0.00.00.30.20.10.10.1-0.10.10.0-0.1-0.00.10.1-0.1-0.10.6
Progressive ratio test 2 active lever presses0.10.10.4-0.50.40.40.4-0.40.6-0.40.2-0.20.20.2-0.3-0.30.4
Progressive ratio test 2 breakpoint0.10.10.6-0.20.10.10.1-0.10.20.0-0.20.2-0.2-0.20.20.10.8
Progressive ratio test 2 inactive lever presses0.20.20.3-0.50.50.50.5-0.50.6-0.50.3-0.50.50.5-0.4-0.4-0.1
Incentive Sensitization - Responses0.40.40.7-0.70.70.70.7-0.70.8-0.70.5-0.50.50.5-0.6-0.6-0.5
Incentive Sensitization - Breakpoint0.20.20.4-0.60.50.50.5-0.50.6-0.50.4-0.30.30.3-0.4-0.5-0.4
Sum of active levers in priming session hrs 5-62.52.43.4-1.71.61.61.6-1.61.6-1.71.8-1.41.41.4-1.7-1.80.3
Progressive ratio0.10.20.90.4-0.3-0.3-0.30.3-0.20.2-0.20.4-0.5-0.4-0.0-0.30.9
Food seeking constrained by brief footshock0.00.10.30.4-0.1-0.1-0.10.10.0-0.10.20.0-0.00.0-0.4-0.50.2
Seeking ratio, punishment vs. effort0.10.10.6-0.00.20.20.2-0.20.2-0.20.3-0.40.40.4-0.3-0.1-0.8
Retroperitoneal fat weight0.10.21.10.6-0.4-0.4-0.40.4-0.20.2-0.30.4-0.4-0.4-0.0-0.21.1
Reaction time number correct1.42.12.51.6-1.5-1.5-1.51.5-1.51.5-1.31.6-1.6-1.61.31.20.2
Reaction time mean minus median3.14.14.8-2.22.12.12.1-2.12.0-2.02.0-2.22.22.2-1.9-1.7-1.7
Reaction time mean minus median AUC2.12.73.8-2.01.71.71.7-1.71.7-1.71.7-1.81.71.7-1.5-1.4-1.0
Reaction time num false alarms3.75.08.92.5-2.2-2.2-2.22.2-2.22.1-2.22.3-2.3-2.31.71.53.0
Reaction time num false alarms AUC3.54.87.12.7-2.2-2.2-2.22.2-2.22.2-2.22.2-2.2-2.21.71.52.4
Reaction time trials correct on left1.42.12.51.6-1.5-1.5-1.51.5-1.51.5-1.31.6-1.6-1.61.31.20.2
Reaction time trials on left1.31.92.31.5-1.5-1.5-1.51.5-1.51.4-1.21.5-1.5-1.51.31.20.2
Reaction time mean7.911.113.9-3.73.63.63.6-3.63.5-3.43.5-3.33.23.2-3.2-3.3-0.7
Reaction time mean AUC6.99.312.3-3.53.33.33.3-3.33.2-3.23.2-3.03.03.0-3.0-3.0-0.4
Median of all reaction times7.410.113.1-3.63.43.43.4-3.43.4-3.33.4-3.03.03.0-3.1-3.20.1
Reaction time omissions0.30.41.0-1.00.70.70.7-0.70.6-0.70.8-0.50.50.5-0.5-0.50.4
Reaction time false alarm rate1.41.94.61.6-1.3-1.3-1.31.3-1.31.3-1.41.3-1.3-1.31.00.92.1
Reaction time premature initiation rate0.00.00.3-0.1-0.0-0.0-0.00.00.00.0-0.10.0-0.0-0.00.10.10.6
Reaction time premature initiations0.40.60.70.7-0.8-0.8-0.80.8-0.70.8-0.70.8-0.8-0.80.70.70.6
Std. dev. reaction times7.310.212.2-3.53.33.33.3-3.33.3-3.23.3-3.43.33.3-3.0-2.9-1.8
Reaction time trials completed1.31.92.31.5-1.5-1.5-1.51.5-1.51.4-1.21.5-1.5-1.51.31.20.2
Reaction time trials AUC1.31.92.31.5-1.5-1.5-1.51.4-1.51.4-1.21.5-1.5-1.51.31.20.1
Run reversals in cocaine runway, females0.40.34.20.5-0.1-0.1-0.10.1-0.10.1-0.20.2-0.2-0.2-0.2-0.32.1
Run reversals in cocaine runway, males1.00.95.41.1-0.8-0.8-0.80.8-0.80.8-0.80.8-0.8-0.80.40.32.3
Latency to leave start box in cocaine runway6.16.67.72.7-2.8-2.8-2.82.8-2.72.7-2.72.6-2.6-2.62.52.5-0.0
Latency to leave start box in cocaine runway, F4.04.45.72.1-2.3-2.3-2.32.3-2.22.2-2.21.9-1.8-1.92.22.4-1.1
Latency to leave start box in cocaine runway, M1.81.72.91.7-1.3-1.3-1.31.3-1.31.3-1.31.5-1.5-1.40.90.61.3
Std. dev. time between licks in bursts6.17.38.52.8-2.8-2.8-2.82.8-2.72.8-2.92.8-2.8-2.82.62.51.3
Total sessions with >9 infusions0.40.51.61.3-0.6-0.6-0.60.6-0.40.6-0.90.6-0.6-0.60.30.21.1
Short access day 1 total inactive lever presses0.00.00.10.30.00.00.0-0.0-0.30.1-0.0-0.00.00.1-0.2-0.10.2
Short access day 10 total inactive lever presses0.60.70.9-0.70.90.90.9-0.90.7-0.90.9-0.90.90.9-1.0-1.0-0.2
Short access day 1 total infusions0.10.10.70.4-0.1-0.1-0.10.10.10.0-0.3-0.10.20.10.10.2-0.8
Short access day 10 total infusions0.10.11.0-0.40.10.10.1-0.10.10.1-0.40.3-0.3-0.30.50.41.0
Short access total infusions0.20.20.60.4-0.3-0.3-0.30.3-0.20.3-0.80.4-0.4-0.40.50.50.6
Short access day 1 locomotion0.10.10.40.5-0.1-0.1-0.10.10.10.2-0.40.00.00.0-0.00.00.6
Short access day 10 total locomotion0.20.20.4-0.20.50.50.5-0.50.6-0.50.3-0.40.40.5-0.6-0.7-0.3
Short access total locomotion0.10.10.60.7-0.2-0.2-0.20.2-0.00.2-0.50.2-0.2-0.1-0.1-0.10.5
One hour access (0.3 mA shock)0.20.21.4-0.70.30.30.3-0.30.6-0.40.3-0.20.10.1-0.1-0.11.2
Compulsive drug intake0.20.20.30.2-0.5-0.5-0.50.5-0.40.3-0.10.5-0.5-0.50.40.30.2
One hour access (shock baseline)0.20.30.6-0.80.60.60.6-0.60.7-0.50.3-0.40.40.4-0.3-0.30.3
Social response proportion0.91.01.2-1.11.11.11.1-1.11.0-1.11.1-0.90.90.9-1.0-1.10.6
Social responses0.10.22.20.00.10.10.1-0.1-0.1-0.10.10.1-0.1-0.1-0.2-0.31.5
Social time0.50.71.5-1.20.90.90.9-0.90.7-0.90.9-0.80.70.7-0.6-0.6-0.0
Soleus weight0.20.52.01.4-0.6-0.6-0.60.6-0.80.7-0.80.6-0.6-0.50.20.10.8
Bone: stiffness1.72.64.8-0.81.61.61.6-1.61.7-1.61.6-1.71.71.7-2.1-2.20.3
Tibialis anterior weight2.69.013.43.7-3.1-3.1-3.13.1-3.23.2-3.13.1-3.1-3.02.62.41.6
Time to tail flick, vehicle, before self-admin0.70.70.80.8-0.9-0.9-0.90.9-0.90.9-0.90.9-0.9-0.90.90.9-0.3
Time to tail flick, vehicle, after self-admin0.10.10.2-0.50.40.40.4-0.40.4-0.40.4-0.30.20.2-0.3-0.30.2
Time to tail flick, test, before self-admin1.31.24.71.2-1.0-1.0-1.01.0-1.01.0-0.91.1-1.1-1.10.60.52.2
Time to tail flick, test, after self-admin1.61.72.81.7-1.3-1.3-1.31.3-1.41.4-1.31.3-1.2-1.21.11.11.0
Delta time to tail flick, vehicle, before/after SA0.90.91.1-0.91.01.01.0-1.01.0-1.01.0-1.01.01.0-1.0-0.9-0.3
Delta time to tail flick, test, before/after SA0.30.22.00.3-0.3-0.3-0.30.3-0.30.3-0.3-0.00.10.10.50.7-1.4
Tibia length4.813.416.5-2.93.73.73.7-3.73.8-3.83.7-3.93.93.9-4.1-4.0-1.8
Ambulatory time before self-admin5.55.76.3-2.12.52.52.5-2.52.4-2.42.3-2.52.52.5-2.5-2.4-2.1
Ambulatory time after self-admin0.20.30.6-0.30.50.50.5-0.50.4-0.50.6-0.50.50.5-0.7-0.80.2
Bone: tissue strength0.00.00.10.10.00.00.0-0.0-0.00.0-0.2-0.10.10.1-0.1-0.1-0.4
Total heroin consumption0.60.71.3-1.10.80.80.8-0.80.8-1.01.0-1.01.00.9-0.6-0.5-0.3
Bone: trabecular number1.32.13.2-1.41.41.41.4-1.41.4-1.41.4-1.61.61.6-1.2-1.1-1.8
Bone: trabecular spacing0.50.65.90.7-0.4-0.4-0.40.4-0.40.4-0.30.7-0.7-0.70.1-0.12.4
Bone: trabecular thickness3.33.98.4-2.31.91.91.9-1.92.0-1.91.8-2.12.12.1-1.4-1.2-2.9
Bone: trabecular tissue density0.30.41.6-0.40.50.50.5-0.50.6-0.60.6-0.40.40.4-0.8-0.91.3
Water consumed over 24 hours0.80.91.20.9-1.0-1.0-1.01.0-1.11.0-0.71.0-1.0-1.01.11.1-0.3
Number of responses in last shaping day0.20.20.40.6-0.4-0.4-0.40.4-0.50.5-0.60.5-0.5-0.50.40.40.6