Hub : Genes

Nab1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Nab1 0.18 0.12 4.9e-06 0.06 0.07 0.07 0.07 3.6e-04 1.1e-04 1.1e-04 1.2e-04
2 NAcc gene expression Nab1 0.09 0.05 8.6e-14 0.06 0.05 0.04 0.05 1.6e-09 4.0e-08 2.2e-07 2.0e-08
3 OFC gene expression Nab1 0.39 0.16 2.2e-07 0.22 0.21 0.2 0.21 6.5e-06 1.0e-05 2.1e-05 8.4e-06
4 LHb gene expression Nab1 0.29 0.18 3.6e-04 0.01 -0.01 -0 0.03 1.7e-01 8.0e-01 3.6e-01 5.6e-02
5 Adipose mRNA stability Nab1 0.08 0.05 3.8e-09 0.06 0.05 0.05 0.06 3.6e-07 1.6e-06 3.1e-06 4.2e-07
6 OFC alternative polyA XM_039084185.2 0.17 0.11 2.8e-03 0 0.02 0.01 0 3.0e-01 1.0e-01 2.2e-01 2.8e-01
7 pVTA gene expression Nab1 0.19 0.09 0.0e+00 0.25 0.25 0.24 0.25 9.0e-20 2.6e-20 2.3e-19 1.0e-19
8 Brain gene expression Nab1 0.18 0.09 0.0e+00 0.22 0.22 0.22 0.23 4.9e-20 1.1e-20 1.1e-20 5.2e-21
9 PL gene expression Nab1 0.08 0.05 1.9e-09 0.09 0.08 0.08 0.08 7.5e-10 3.7e-09 9.3e-09 2.3e-09
10 OFC alternative polyA XM_039084185.2 0.37 0.18 3.9e-05 0.02 0.08 0.04 0.08 9.3e-02 6.3e-03 3.9e-02 6.3e-03
11 OFC isoform ratio NM_022856.5 0.24 0.15 9.3e-04 0.01 0.04 0.02 0.03 1.5e-01 4.1e-02 9.9e-02 7.4e-02
12 OFC alternative polyA NM_022856.5 0.31 0.19 4.0e-04 0.02 0.04 0.02 0.04 1.2e-01 3.4e-02 1.3e-01 3.5e-02
13 IC gene expression Nab1 0.18 0.11 2.8e-06 0.12 0.12 0.11 0.11 9.6e-06 7.4e-06 2.8e-05 2.3e-05
14 OFC alternative polyA NM_022856.5 0.33 0.19 3.3e-04 0.02 0.05 0.02 0.04 1.0e-01 2.9e-02 1.3e-01 3.3e-02
15 Adipose gene expression Nab1 0.25 0.1 0.0e+00 0.23 0.24 0.23 0.23 5.8e-25 7.8e-26 5.5e-25 4.0e-25

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density2.54.25.4-2.2-2.0-2.0-2.0-2.0-2.1-2.1-1.9-1.9-2.12.32.2-2.22.2-1.6
Area under the delay curve0.00.00.10.10.00.00.00.00.10.10.10.10.1-0.2-0.20.2-0.20.2
BMI with tail6.221.322.74.54.74.74.74.74.64.64.74.84.7-4.5-4.64.5-4.54.5
BMI without tail1.23.64.61.41.91.91.91.91.91.92.02.01.9-1.8-1.91.9-1.92.1
Body weight0.00.00.1-0.1-0.3-0.3-0.3-0.2-0.1-0.1-0.2-0.1-0.0-0.10.0-0.0-0.0-0.4
Weight adjusted by age0.91.42.3-0.7-1.2-1.2-1.2-1.3-1.1-1.1-1.2-1.2-1.11.01.2-1.21.1-1.5
Bone surface0.71.21.5-0.8-1.1-1.1-1.1-1.1-1.1-1.1-1.0-1.0-1.01.21.2-1.21.2-1.2
Bone volume2.34.14.6-1.9-2.0-2.0-2.0-2.0-2.0-2.0-1.9-1.9-2.02.22.1-2.12.1-1.9
Breakpoint value in progressive ratio session1.01.21.9-1.4-1.1-1.1-1.1-1.1-1.1-1.1-1.2-1.2-1.10.90.9-0.90.9-0.9
Number of licking bursts0.10.20.7-0.10.50.50.50.50.30.30.40.50.4-0.2-0.40.4-0.40.8
Context. condit. distance diff. score1.51.82.80.61.31.31.31.31.31.31.31.41.3-1.4-1.51.5-1.51.7
Locomotion velocity, session 10.00.10.10.10.20.20.20.20.20.20.20.20.2-0.3-0.30.3-0.30.3
Locomotion distance, session 10.30.30.60.60.50.50.50.50.60.60.60.50.6-0.7-0.70.7-0.70.4
Locomotion velocity, session 21.82.12.91.71.41.41.41.41.51.51.51.41.5-1.5-1.51.4-1.51.2
Locomotion distance, session 20.60.91.41.20.90.90.90.91.01.00.90.91.0-1.1-1.00.9-1.00.5
Locomotion velocity, session 30.20.20.30.40.50.50.50.50.50.50.50.50.5-0.5-0.50.5-0.50.5
Locomotion distance, session 30.30.40.70.40.60.60.60.60.50.60.70.70.6-0.4-0.50.5-0.50.8
Stereotopy head waving bouts, day 30.60.70.80.90.80.80.80.80.90.90.80.80.8-0.9-0.90.9-0.90.7
Stereotopy head waving duration, day 30.00.00.10.10.20.20.20.20.20.20.10.10.1-0.3-0.30.3-0.30.2
Locomotion velocity, session 70.10.10.40.60.10.10.10.10.20.20.10.10.2-0.4-0.20.2-0.2-0.3
Locomotion distance, session 70.10.10.40.60.10.10.10.10.30.30.20.20.4-0.5-0.40.3-0.4-0.2
Stereotopy head waving bouts, day 70.20.20.4-0.6-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.50.40.4-0.40.4-0.3
Stereotopy head waving duration, day 70.60.80.9-1.0-0.9-0.9-0.9-0.9-0.9-0.9-0.9-0.9-0.90.90.9-0.90.9-0.7
Locomotion velocity, session 80.30.40.70.40.70.70.70.70.60.60.70.60.6-0.5-0.60.6-0.60.8
Locomotion distance, session 81.82.52.71.31.61.61.61.61.61.61.61.61.6-1.6-1.71.7-1.71.7
Degree of sensitization distance0.30.31.1-0.1-0.7-0.7-0.7-0.7-0.4-0.5-0.7-0.6-0.50.20.4-0.50.4-1.1
Degree of sensitization stereotypy0.20.20.4-0.7-0.5-0.5-0.5-0.5-0.5-0.5-0.4-0.4-0.50.50.5-0.40.5-0.2
Conditioned locomotion0.00.00.1-0.1-0.1-0.1-0.1-0.10.00.0-0.1-0.1-0.0-0.3-0.20.2-0.2-0.2
Cocaine response after cond. corrected0.00.00.20.4-0.1-0.1-0.1-0.10.10.1-0.1-0.10.0-0.3-0.20.1-0.2-0.5
Cocaine response after cond. not corrected0.80.92.3-0.4-1.1-1.1-1.1-1.1-0.8-0.8-1.0-1.1-0.90.60.8-0.90.8-1.5
Cocaine response before conditioning1.21.41.9-0.9-1.2-1.2-1.2-1.2-1.2-1.2-1.2-1.1-1.21.21.2-1.31.2-1.4
Saline control response0.00.00.1-0.00.20.20.20.20.10.10.20.20.20.0-0.10.1-0.10.4
Bone: connectivity density0.20.40.6-0.6-0.5-0.5-0.5-0.5-0.6-0.6-0.5-0.5-0.60.80.7-0.70.7-0.4
Bone: cortical apparent density7.310.010.93.33.13.13.13.13.23.23.13.13.2-3.3-3.23.2-3.22.8
Bone: cortical area0.10.10.30.50.10.10.10.10.30.30.10.10.3-0.5-0.40.3-0.4-0.2
Bone: cortical porosity1.71.82.7-1.5-1.3-1.3-1.3-1.3-1.4-1.4-1.2-1.1-1.31.61.5-1.51.5-1.0
Bone: cortical porosity3.13.34.4-1.8-1.8-1.8-1.8-1.7-1.9-1.9-1.7-1.6-1.82.12.0-2.02.0-1.6
Bone: cortical thickness2.03.34.11.81.81.81.81.71.91.91.81.71.8-2.0-1.92.0-2.01.6
Bone: cortical thickness0.00.00.10.30.20.20.20.10.10.10.0-0.10.0-0.2-0.10.1-0.1-0.1
Bone: cortical tissue density6.99.410.33.23.03.03.03.13.13.13.03.03.1-3.2-3.13.1-3.12.7
Condit. Reinf. active minus inactive responses5.15.76.6-2.6-2.5-2.5-2.5-2.5-2.4-2.4-2.5-2.5-2.42.12.2-2.22.2-2.3
Condit. Reinf. active-inactive response ratio2.93.13.7-1.9-1.9-1.9-1.9-1.9-1.7-1.8-1.8-1.8-1.81.51.6-1.61.6-1.7
Condit. Reinf. active responses4.25.26.0-2.3-2.4-2.4-2.4-2.4-2.2-2.3-2.4-2.5-2.32.02.1-2.12.1-2.4
Condit. Reinf. inactive responses0.10.10.3-0.2-0.4-0.4-0.4-0.4-0.2-0.2-0.4-0.4-0.30.00.2-0.20.1-0.6
Incentive salience index mean3.74.65.7-2.4-2.2-2.2-2.2-2.2-2.2-2.2-2.2-2.2-2.22.02.0-2.02.0-1.9
Condit. Reinf. lever presses0.50.71.5-1.2-0.9-0.9-0.9-0.9-0.9-0.9-0.8-0.8-0.90.90.8-0.80.8-0.5
Condit. Reinf. active minus inactive responses3.95.15.5-2.2-2.3-2.3-2.3-2.3-2.2-2.3-2.3-2.3-2.32.12.2-2.22.2-2.3
Condit. Reinf. active-inactive response ratio3.23.84.1-2.0-1.9-1.9-1.9-1.9-2.0-2.0-1.9-1.9-2.01.91.9-1.91.9-1.8
Condit. Reinf. active responses1.21.62.1-1.1-1.4-1.4-1.4-1.4-1.2-1.2-1.3-1.3-1.21.01.1-1.21.1-1.5
Condit. Reinf. inactive responses0.00.00.10.3-0.1-0.1-0.1-0.10.10.1-0.00.00.1-0.2-0.10.0-0.1-0.3
Condit. Reinf. lever presses0.10.20.2-0.3-0.5-0.5-0.5-0.4-0.4-0.4-0.3-0.3-0.40.50.5-0.50.5-0.4
Condit. Reinf. lever reinforcers received1.01.42.0-0.9-1.3-1.3-1.3-1.3-1.1-1.1-1.2-1.2-1.10.91.0-1.11.0-1.4
Conditioned reinforcement - actives0.10.10.10.40.20.20.20.20.30.30.30.40.4-0.3-0.30.3-0.30.2
Conditioned reinforcement - inactives0.10.10.1-0.1-0.3-0.3-0.3-0.3-0.2-0.2-0.3-0.3-0.40.10.2-0.20.2-0.4
Conditioned locomotion0.91.22.81.70.90.90.90.91.21.21.21.11.1-1.1-1.01.0-1.00.7
Patch foraging indifference point 0 sec3.36.17.52.72.72.72.72.72.42.42.62.62.5-2.0-2.22.1-2.12.5
Patch foraging indifference point AUC0.00.10.40.60.20.20.20.20.20.20.30.30.30.10.1-0.10.1-0.0
Delay disc. indifference point, 0s delay0.00.00.00.10.10.10.10.10.00.00.10.20.00.10.1-0.10.10.1
Delay disc. indifference point, 16s delay0.40.40.7-0.8-0.8-0.8-0.8-0.8-0.6-0.6-0.7-0.7-0.70.50.5-0.50.5-0.5
Delay disc. indifference point, 2s delay0.00.00.00.10.00.00.00.00.00.00.10.10.00.10.1-0.10.10.1
Delay disc. indifference point, 24s delay0.10.10.30.00.20.20.20.20.30.40.30.20.2-0.5-0.50.6-0.50.5
Delay disc. indifference point, 4s delay0.50.50.70.80.70.70.70.70.70.70.70.80.7-0.7-0.70.7-0.70.7
Delay disc. indifference point, 8s delay0.20.30.5-0.5-0.7-0.7-0.7-0.7-0.5-0.5-0.6-0.6-0.60.30.4-0.30.4-0.6
Indifference point function ln k0.71.22.00.61.11.11.11.11.11.11.11.01.1-1.1-1.21.2-1.21.4
Indifference point function log k0.71.22.00.61.11.11.11.11.11.11.11.01.1-1.1-1.21.2-1.21.4
Patch foraging total patch changes 0 sec3.15.87.12.62.72.72.72.72.32.42.62.62.4-1.9-2.12.0-2.02.4
Patch foraging total patch changes 12 sec0.30.41.01.00.70.70.70.80.60.60.70.80.7-0.3-0.40.3-0.30.5
Patch foraging total patch changes 18 sec1.42.13.01.71.61.61.61.71.41.41.61.61.5-1.0-1.21.1-1.11.5
Patch foraging total patch changes 24 sec0.50.91.51.21.11.11.11.20.90.91.01.11.0-0.5-0.60.6-0.60.9
Patch foraging total patch changes 6 sec3.14.86.32.52.32.32.32.42.12.22.42.42.2-1.7-1.81.8-1.82.2
Patch foraging time to switch 0 sec0.71.41.8-1.3-1.2-1.2-1.2-1.2-1.2-1.2-1.3-1.3-1.31.11.1-1.11.1-1.1
Patch foraging water rate 0 sec0.61.31.91.11.11.11.11.11.11.11.21.31.4-1.1-1.11.1-1.11.0
Patch foraging water rate 12 sec0.30.60.80.50.70.70.70.80.70.70.70.70.8-0.7-0.80.8-0.80.9
Patch foraging water rate 18 sec0.10.10.2-0.10.40.40.40.40.30.30.30.30.4-0.4-0.40.4-0.40.5
Patch foraging water rate 24 sec0.00.00.1-0.1-0.0-0.0-0.0-0.10.00.0-0.0-0.10.1-0.2-0.20.2-0.2-0.1
Patch foraging water rate 6 sec1.42.02.81.01.51.51.51.51.41.41.41.41.4-1.3-1.41.4-1.41.7
Seeking ratio, delayed vs. immediate footshock3.13.83.9-1.8-2.0-2.0-2.0-1.9-1.9-1.9-1.9-2.0-2.01.92.0-2.02.0-1.9
Distance traveled before self-admin5.87.68.1-2.6-2.7-2.7-2.7-2.7-2.8-2.8-2.7-2.7-2.72.82.8-2.82.8-2.6
Distance traveled after self-admin2.32.83.1-1.7-1.7-1.7-1.7-1.6-1.7-1.7-1.7-1.7-1.61.61.7-1.71.7-1.8
Extensor digitorum longus weight4.818.927.65.34.14.14.14.14.54.54.24.34.6-4.8-4.54.3-4.53.0
Bone: elastic displacement0.10.10.5-0.7-0.3-0.3-0.3-0.3-0.4-0.4-0.2-0.2-0.30.50.3-0.30.40.2
Bone: elastic work1.72.22.4-1.5-1.5-1.5-1.5-1.5-1.5-1.5-1.5-1.5-1.51.51.5-1.51.5-1.4
Bone: endosteal estimation4.19.111.0-2.5-3.1-3.1-3.1-3.1-3.0-3.0-3.0-2.9-2.92.93.0-3.13.0-3.3
Bone: endosteal perimeter1.53.24.2-1.5-1.9-1.9-1.9-1.9-1.7-1.7-1.8-1.8-1.71.51.7-1.71.7-2.1
Epididymis fat weight0.31.02.5-0.5-1.1-1.1-1.1-1.1-0.9-0.9-1.2-1.2-0.90.50.8-0.80.7-1.6
Delta time in closed arm before/after self-admin0.70.70.80.90.80.80.80.90.80.80.80.80.8-0.8-0.80.8-0.80.8
Delta time in open arm before/after self-admin5.65.66.3-2.3-2.3-2.3-2.3-2.3-2.4-2.4-2.4-2.3-2.32.52.5-2.52.5-2.2
Diff in mean of infusions in LGA sessions1.01.21.4-1.2-1.1-1.1-1.1-1.1-1.1-1.1-1.1-1.1-1.11.01.0-1.01.0-1.0
Delay discount exponential model param0.00.00.1-0.1-0.1-0.1-0.1-0.1-0.2-0.2-0.2-0.2-0.10.30.3-0.30.3-0.2
Extinction: sum of active levers before priming1.01.11.4-1.2-1.1-1.1-1.1-1.1-1.0-1.0-1.1-1.1-1.00.91.0-0.90.9-1.0
Active lever presses in extinction session 61.00.91.4-1.2-0.9-0.9-0.9-0.9-1.0-1.0-1.0-1.0-1.01.01.0-0.91.0-0.8
Bone: final force0.81.32.4-0.7-1.3-1.3-1.3-1.3-1.0-1.0-1.1-1.1-1.00.91.0-1.11.0-1.6
Bone: final moment0.40.61.3-0.3-0.9-0.9-0.9-0.9-0.7-0.7-0.7-0.7-0.60.50.7-0.80.7-1.1
Food consumed during 24 hour testing period0.60.81.1-0.5-0.9-0.9-0.9-0.9-0.9-0.9-0.9-0.9-0.80.91.0-1.01.0-1.0
Glucose0.30.51.30.20.80.80.80.90.60.60.80.80.7-0.5-0.70.7-0.61.1
Heart weight0.20.30.4-0.5-0.6-0.6-0.6-0.6-0.5-0.5-0.5-0.6-0.60.50.5-0.50.5-0.6
Delay discount hyperbolic model param0.10.10.1-0.2-0.2-0.2-0.2-0.2-0.3-0.3-0.2-0.3-0.20.30.3-0.30.3-0.3
Intermittent access intake day 1-15 change0.61.31.51.21.11.11.11.11.21.21.11.21.2-1.2-1.21.2-1.21.0
Intermittent access intake escalation1.12.22.31.51.51.51.51.51.51.51.51.51.5-1.5-1.51.5-1.51.4
Intermittent access intake escalation 20.60.70.80.70.90.90.90.90.80.80.80.80.9-0.8-0.80.8-0.80.9
Intermitt. access day 1 inactive lever presses1.24.65.21.92.32.32.32.32.12.12.22.32.3-1.9-2.02.0-2.02.3
Intermitt. access day 15 inactive lever presses0.10.20.30.30.50.50.50.50.50.50.40.50.5-0.5-0.50.5-0.50.5
Intermitt. access escalation Index0.50.71.00.50.80.80.80.80.80.80.60.60.8-1.0-0.91.0-0.90.9
Intermittent access day 1 total infusions0.10.20.3-0.6-0.5-0.5-0.5-0.5-0.4-0.4-0.3-0.3-0.50.40.3-0.30.3-0.1
Intermittent access day 15 total infusions1.62.42.71.31.51.51.51.51.61.61.61.61.4-1.6-1.61.6-1.61.6
Intermittent access terminal intake (last 3 days)2.43.23.71.61.81.81.81.81.81.81.81.81.6-1.8-1.81.8-1.81.9
Intermittent access total infusions0.30.40.60.50.50.50.50.50.60.60.70.60.4-0.6-0.70.7-0.70.8
Intermittent access day 1 locomotion0.00.00.00.0-0.1-0.1-0.1-0.10.00.00.00.0-0.2-0.0-0.00.0-0.00.0
Intermittent access day 15 total locomotion0.10.20.50.70.20.20.20.20.50.50.50.60.4-0.6-0.50.4-0.50.1
Intermittent access total locomotion0.60.81.20.90.70.70.70.70.90.91.01.10.8-0.9-0.90.9-0.90.8
Intermittent access standard deviation0.40.81.11.00.90.90.90.90.90.90.91.00.9-0.9-0.90.8-0.90.8
Left kidney weight0.00.20.3-0.5-0.5-0.5-0.5-0.5-0.4-0.4-0.5-0.4-0.20.40.4-0.40.4-0.4
Right kidney weight0.10.20.50.70.40.40.40.40.50.50.40.50.6-0.6-0.50.5-0.50.2
Cocaine induced anxiety1.52.12.41.51.41.41.41.41.51.51.41.41.5-1.5-1.51.5-1.51.3
Post-drug Anxiety1.51.72.11.41.21.21.21.21.31.31.21.21.3-1.4-1.41.3-1.41.0
Baseline Anxiety1.41.61.7-1.2-1.3-1.3-1.3-1.3-1.3-1.3-1.3-1.3-1.31.21.3-1.31.3-1.3
Tail length4.919.221.5-4.5-4.6-4.6-4.6-4.6-4.4-4.4-4.4-4.4-4.34.14.2-4.24.1-4.3
Length with tail6.226.830.3-4.9-5.5-5.5-5.5-5.5-5.1-5.1-5.3-5.3-5.04.74.9-5.04.9-5.4
Length without tail2.37.310.4-2.0-2.8-2.8-2.8-2.8-2.6-2.6-2.8-2.8-2.52.42.6-2.72.6-3.2
Times rat made contact with spout0.00.10.4-0.40.20.20.20.2-0.0-0.00.20.20.10.20.00.00.00.6
Lifetime Intake0.60.71.00.80.80.80.80.80.90.90.90.80.6-0.9-0.90.9-0.91.0
Liver weight, left1.11.92.8-1.1-1.4-1.4-1.4-1.5-1.3-1.4-1.5-1.3-1.21.21.3-1.41.3-1.7
Liver weight, right0.50.81.0-0.7-0.9-0.9-0.9-0.9-0.9-0.9-1.0-1.0-0.90.80.9-0.80.9-1.0
Locomotor activity0.00.10.10.20.30.30.30.30.20.20.10.20.2-0.2-0.20.2-0.20.2
Locomotor testing distance0.00.00.1-0.20.10.10.10.1-0.1-0.1-0.1-0.1-0.20.30.2-0.10.20.2
Locomotor testing rearing0.30.71.20.40.90.90.90.90.80.80.80.80.7-0.7-0.80.9-0.81.1
Locomotion in novel chamber0.70.92.71.60.90.90.90.81.01.01.00.91.0-1.0-0.90.8-0.90.4
Locomotion in novel chamber post-restriction0.50.81.91.40.90.90.90.81.01.00.90.91.0-1.0-0.90.8-0.90.5
Fecal boli incidents, locomotor time 10.00.00.1-0.1-0.1-0.1-0.1-0.1-0.1-0.10.0-0.1-0.10.20.2-0.10.20.1
Change in fecal boli incidents, locomotor task0.20.20.20.20.40.40.40.40.40.40.40.50.4-0.4-0.40.4-0.40.4
Time >=10cm from walls, locomotor time 10.00.10.30.60.10.10.10.10.20.20.10.10.2-0.3-0.20.2-0.2-0.2
Bouts of movement, locomotor time 11.21.31.41.21.11.11.11.11.21.21.21.21.2-1.1-1.21.2-1.21.1
Total resting periods, locomotor time 11.71.92.21.51.41.41.41.41.41.41.41.41.4-1.4-1.41.4-1.41.3
Rest time, locomotor task time 10.50.71.00.60.90.90.90.90.80.80.90.80.8-0.7-0.80.8-0.81.0
Distance moved, locomotor task time 10.10.20.3-0.6-0.5-0.5-0.5-0.5-0.4-0.4-0.5-0.5-0.40.20.2-0.20.2-0.4
Vertical activity count, locomotor time 10.00.00.0-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.0-0.1-0.00.0-0.00.0-0.2
Time >=10cm from walls, locomotor time 20.91.41.8-1.4-1.2-1.2-1.2-1.2-1.2-1.2-1.1-1.0-1.21.21.2-1.21.2-1.0
Bouts of movement, locomotor time 22.94.65.42.22.02.02.02.02.22.22.12.22.2-2.3-2.22.2-2.31.9
Total resting periods, locomotor time 22.64.55.02.22.02.02.02.02.22.22.12.22.2-2.2-2.22.2-2.22.0
Rest time, locomotor task time 21.11.42.11.21.21.21.21.21.21.21.41.31.2-0.9-1.01.0-1.01.4
Distance moved, locomotor task time 20.60.71.0-0.9-0.8-0.8-0.8-0.8-0.8-0.8-1.0-1.0-0.90.60.7-0.70.6-1.0
Vertical activity count, locomotor time 20.10.10.10.00.30.30.30.30.20.20.20.20.2-0.4-0.40.4-0.40.2
Light reinforcement 13.48.311.23.43.03.03.03.03.02.92.82.82.8-2.8-2.82.7-2.82.4
Light reinforcement 20.71.11.51.21.11.11.11.21.01.01.11.00.9-0.9-0.90.9-0.91.0
Bone: marrow area3.88.310.2-2.4-3.0-3.0-3.0-3.0-2.8-2.8-2.9-2.8-2.72.82.9-3.02.9-3.2
Bone: maximum diameter0.00.00.10.2-0.0-0.0-0.0-0.00.20.10.10.10.2-0.3-0.20.2-0.2-0.1
Bone: maximum force1.93.45.4-1.2-2.0-2.0-2.0-2.0-1.7-1.7-1.8-1.7-1.61.61.8-1.91.8-2.3
Bone: maximum moment1.11.93.3-0.8-1.5-1.5-1.5-1.5-1.3-1.3-1.3-1.3-1.21.21.4-1.51.4-1.8
Mean time between licks in bursts0.92.23.61.91.51.51.51.51.51.51.51.61.5-1.4-1.41.3-1.41.1
Mean num. licks in bursts0.00.00.00.1-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.00.10.1-0.10.1-0.2
Cd content in liver2.02.33.4-1.8-1.6-1.6-1.6-1.6-1.5-1.5-1.4-1.6-1.61.31.3-1.31.3-1.3
Co content in liver0.20.21.0-1.0-0.5-0.5-0.5-0.5-0.5-0.5-0.4-0.5-0.50.40.3-0.30.3-0.1
Cu content in liver1.11.32.0-1.4-1.1-1.1-1.1-1.1-1.2-1.2-1.2-1.2-1.21.11.1-1.01.1-0.9
Fe content in liver1.41.73.0-1.7-1.2-1.2-1.2-1.2-1.4-1.4-1.2-1.2-1.41.61.4-1.31.4-0.7
K content in liver1.11.12.11.51.21.21.21.21.01.01.11.11.0-0.7-0.80.8-0.70.9
Mg content in liver0.40.40.60.80.70.70.70.70.60.60.70.70.5-0.3-0.40.4-0.40.7
Mn content in liver0.60.61.00.70.90.90.90.90.70.80.90.90.8-0.5-0.70.7-0.61.0
Na content in liver0.00.00.2-0.10.00.00.00.0-0.2-0.2-0.1-0.1-0.20.40.3-0.30.30.1
Rb content in liver1.92.23.51.91.31.31.31.31.61.51.31.41.6-1.8-1.61.6-1.60.8
Se content in liver0.20.20.30.50.50.50.50.50.40.40.30.50.5-0.4-0.40.4-0.40.5
Sr content in liver0.30.30.30.40.50.50.50.50.50.50.50.50.5-0.5-0.50.5-0.50.5
Zn content in liver0.00.00.10.20.20.20.20.20.20.20.20.10.1-0.2-0.20.2-0.20.2
Bone: minimum diameter0.50.91.7-0.4-1.1-1.1-1.1-1.0-0.8-0.8-0.9-0.9-0.80.70.9-0.90.9-1.3
Time in familiar zone, hab. session 10.60.60.80.50.70.70.70.70.70.70.80.70.7-0.8-0.80.8-0.80.9
Time in novel zone, hab. session 14.24.24.7-2.2-2.0-2.0-2.0-2.0-2.1-2.1-2.0-1.9-2.02.12.1-2.12.1-1.8
Total zone transitions, hab. session 10.20.30.8-0.1-0.6-0.6-0.6-0.6-0.4-0.5-0.5-0.5-0.40.30.5-0.50.5-0.9
Total locomotion distance, hab. session 11.11.63.2-0.6-1.3-1.3-1.3-1.3-1.2-1.2-1.3-1.3-1.11.11.2-1.31.2-1.8
Locomotion velocity, hab. session 10.20.31.10.2-0.5-0.5-0.5-0.5-0.4-0.4-0.5-0.5-0.30.30.5-0.60.5-1.0
Time in familiar zone, hab. session 20.00.00.0-0.10.00.00.00.0-0.00.00.0-0.0-0.00.0-0.00.0-0.00.2
Time in novel zone, hab. session 20.00.00.0-0.10.00.00.00.00.00.00.00.10.1-0.0-0.10.1-0.10.1
Total zone transitions, hab. session 20.00.00.00.00.10.10.10.10.10.10.20.10.2-0.2-0.20.2-0.20.2
Total locomotion distance, hab. session 20.40.50.9-0.5-0.7-0.7-0.7-0.7-0.6-0.6-0.7-0.8-0.60.40.6-0.60.5-1.0
Locomotion velocity, hab. session 20.20.30.8-0.3-0.6-0.6-0.6-0.6-0.5-0.5-0.6-0.6-0.50.30.4-0.50.4-0.9
Novel to familiar place preference ratio1.71.82.0-1.4-1.3-1.3-1.3-1.3-1.4-1.4-1.4-1.3-1.31.41.4-1.41.4-1.2
Novelty place preference1.11.21.6-1.2-1.0-1.0-1.0-1.0-1.1-1.1-1.1-1.0-1.11.21.1-1.11.1-0.8
Time in novel zone, NPP test1.31.41.9-1.4-1.1-1.1-1.1-1.1-1.2-1.2-1.2-1.1-1.21.21.2-1.21.2-0.9
Total zone transitions, NPP test0.40.61.00.70.70.70.70.70.80.80.70.60.8-1.0-0.90.9-0.90.5
Total locomotion distance, NPP test0.20.20.5-0.2-0.4-0.4-0.4-0.4-0.4-0.4-0.4-0.5-0.50.40.5-0.50.5-0.7
Locomotion velocity, NPP test0.00.00.10.3-0.0-0.0-0.0-0.00.0-0.0-0.0-0.1-0.00.00.1-0.10.1-0.3
Intraocular pressure0.40.60.80.60.80.80.80.80.80.80.80.70.8-0.8-0.80.9-0.90.8
Delta distance traveled before/after self-admin0.50.50.70.50.70.70.70.70.70.70.60.70.8-0.9-0.80.8-0.80.5
Delta ambulatory time before/after self-admin0.70.81.10.80.90.90.90.90.90.90.80.91.0-1.1-1.01.0-1.00.6
Parametrial fat weight0.61.41.60.91.31.31.31.31.21.21.11.21.3-1.2-1.21.2-1.21.2
Pavlov. Cond. lever latency1.92.43.71.91.51.51.51.51.61.61.51.41.5-1.7-1.61.5-1.61.1
Pavlov. Cond. magazine entry latency3.54.55.4-2.3-2.1-2.1-2.1-2.1-2.2-2.2-2.1-2.1-2.12.22.1-2.12.1-1.9
Pavlov. Cond. change in total contacts2.12.23.1-1.8-1.5-1.5-1.5-1.5-1.5-1.5-1.5-1.4-1.41.41.4-1.41.4-1.3
Pavlov. Cond. index score2.43.14.6-2.2-1.7-1.7-1.7-1.7-1.8-1.8-1.7-1.6-1.71.91.8-1.71.8-1.3
Pavlov. Cond. latency score2.73.55.0-2.2-1.8-1.8-1.8-1.8-1.9-1.9-1.8-1.7-1.82.01.9-1.91.9-1.4
Pavlov. Cond. lever contacts1.51.83.1-1.8-1.3-1.3-1.3-1.3-1.4-1.4-1.3-1.2-1.31.51.4-1.31.4-0.9
Pavlov. Cond. magazine entry number4.25.36.92.62.32.32.32.32.42.42.32.32.3-2.3-2.32.2-2.31.9
Pavlov. Cond. intertrial magazine entries0.10.10.30.30.20.20.20.20.30.30.20.00.2-0.5-0.40.5-0.40.2
Pavlov. Cond. lever-magazine prob. diff.2.32.94.2-2.0-1.7-1.7-1.7-1.7-1.8-1.8-1.6-1.6-1.71.81.7-1.71.7-1.3
Pavlov. Cond. response bias3.03.75.3-2.3-1.9-1.9-1.9-1.9-2.0-2.0-1.9-1.9-1.92.01.9-1.91.9-1.5
Pavlov. Cond. lever latency0.40.60.70.60.70.70.70.70.80.80.70.70.7-0.8-0.80.9-0.80.8
Pavlov. Cond. magazine entry latency0.50.60.7-0.7-0.7-0.7-0.7-0.7-0.8-0.8-0.7-0.7-0.80.80.8-0.80.8-0.7
Pavlov. Cond. change in total contacts1.11.82.1-1.3-1.3-1.3-1.3-1.3-1.4-1.4-1.3-1.3-1.41.51.4-1.41.4-1.3
Pavlov. Cond. index score0.91.21.4-0.9-1.1-1.1-1.1-1.1-1.1-1.1-1.0-1.0-1.11.21.2-1.21.2-1.1
Pavlov. Cond. latency score0.91.21.4-0.8-1.1-1.1-1.1-1.0-1.1-1.1-1.0-1.0-1.11.11.1-1.21.1-1.2
Pavlov. Cond. lever contacts0.81.11.4-1.0-1.0-1.0-1.0-1.0-1.1-1.1-1.0-0.9-1.01.21.1-1.21.1-1.0
Pavlov. Cond. magazine entry number0.70.91.20.90.90.90.90.91.01.00.90.91.0-1.1-1.01.1-1.10.8
Pavlov. Cond. intertrial magazine entries0.91.41.61.01.11.11.11.11.21.21.11.11.2-1.3-1.21.3-1.21.1
Pavlov. Cond. lever-magazine prob. diff.0.50.70.9-0.6-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.90.90.9-1.00.9-0.9
Pavlov. Cond. response bias1.62.22.5-1.3-1.4-1.4-1.4-1.4-1.5-1.5-1.4-1.4-1.51.61.6-1.61.6-1.4
Time in closed arm before self-admin2.63.33.8-1.8-1.7-1.7-1.7-1.8-1.9-1.8-1.8-1.8-1.92.01.9-1.91.9-1.6
Time in closed arm after self-admin0.30.30.4-0.5-0.5-0.5-0.5-0.5-0.6-0.6-0.6-0.6-0.60.60.6-0.60.6-0.6
Time in open arm before self-admin3.23.55.11.91.71.71.71.72.01.91.81.71.9-2.3-2.12.1-2.11.5
Time in open arm after self-admin3.74.14.4-1.9-2.1-2.1-2.1-2.1-2.0-2.0-2.1-2.1-2.02.02.0-2.02.0-2.0
Bone: periosteal estimation1.93.95.6-1.5-2.1-2.1-2.1-2.1-1.9-1.9-2.0-2.0-1.81.81.9-2.01.9-2.4
Bone: periosteal perimeter0.71.21.6-1.0-1.2-1.2-1.2-1.2-1.0-1.0-1.2-1.1-1.00.80.9-1.00.9-1.3
Bone: post-yield work1.21.82.6-1.0-1.4-1.4-1.4-1.4-1.3-1.3-1.4-1.3-1.31.21.3-1.41.3-1.6
Progressive ratio test 1 active lever presses1.11.41.61.21.11.11.11.11.21.21.21.21.1-1.3-1.21.2-1.21.1
Progressive ratio test 1 breakpoint0.70.81.00.90.80.80.80.80.90.90.90.90.8-1.0-1.01.0-1.00.8
Progressive ratio test 1 inactive lever presses2.23.23.51.91.71.71.71.71.81.81.81.81.6-1.9-1.81.8-1.81.7
Progressive ratio test 2 active lever presses0.60.71.00.80.70.70.70.70.90.90.80.80.8-1.0-0.91.0-1.00.8
Progressive ratio test 2 breakpoint0.80.91.20.80.80.80.80.81.01.01.01.00.9-1.1-1.11.1-1.10.9
Progressive ratio test 2 inactive lever presses0.40.60.80.70.70.70.70.70.80.80.70.80.8-0.9-0.80.8-0.80.6
Incentive Sensitization - Responses0.00.00.1-0.3-0.3-0.3-0.3-0.3-0.1-0.2-0.2-0.2-0.2-0.00.0-0.00.0-0.2
Incentive Sensitization - Breakpoint0.00.00.0-0.1-0.1-0.1-0.1-0.10.00.0-0.0-0.00.0-0.2-0.20.2-0.20.0
Sum of active levers in priming session hrs 5-64.23.94.5-2.1-2.0-2.0-2.0-2.0-2.0-2.0-2.1-2.0-1.91.81.8-1.91.8-2.0
Progressive ratio0.20.30.80.70.30.30.30.30.60.50.30.30.5-0.9-0.70.6-0.7-0.0
Food seeking constrained by brief footshock0.00.00.20.40.10.10.10.10.10.1-0.00.00.1-0.2-0.10.1-0.1-0.4
Seeking ratio, punishment vs. effort0.10.10.3-0.1-0.2-0.2-0.2-0.2-0.4-0.4-0.3-0.2-0.30.50.5-0.50.5-0.4
Retroperitoneal fat weight0.20.81.31.00.90.90.90.80.90.90.70.81.0-1.2-1.01.0-1.00.5
Reaction time number correct1.22.32.61.51.51.51.51.51.61.61.51.51.6-1.6-1.61.6-1.61.4
Reaction time mean minus median1.84.65.5-2.2-2.1-2.1-2.1-2.0-2.2-2.2-2.1-2.0-2.22.42.3-2.32.3-1.9
Reaction time mean minus median AUC1.33.44.1-2.0-1.8-1.8-1.8-1.7-1.9-1.9-1.8-1.7-1.92.01.9-1.91.9-1.5
Reaction time num false alarms3.85.36.52.52.22.22.22.22.42.42.22.22.3-2.5-2.42.4-2.41.8
Reaction time num false alarms AUC3.55.46.82.62.32.32.32.32.42.42.22.22.3-2.5-2.42.3-2.41.8
Reaction time trials correct on left1.22.32.61.51.51.51.51.51.61.61.51.51.6-1.6-1.61.6-1.61.4
Reaction time trials on left1.22.22.41.51.51.51.51.41.51.51.51.41.5-1.5-1.51.5-1.51.3
Reaction time mean7.712.314.3-3.8-3.6-3.6-3.6-3.6-3.5-3.5-3.6-3.5-3.53.33.4-3.33.4-3.2
Reaction time mean AUC6.610.512.6-3.5-3.3-3.3-3.3-3.3-3.3-3.3-3.3-3.2-3.23.13.1-3.13.1-2.9
Median of all reaction times8.111.413.9-3.7-3.5-3.5-3.5-3.6-3.4-3.4-3.5-3.4-3.43.13.2-3.13.1-3.1
Reaction time omissions0.10.20.6-0.8-0.4-0.4-0.4-0.4-0.5-0.5-0.5-0.5-0.50.40.4-0.40.4-0.4
Reaction time false alarm rate1.42.02.61.61.41.41.41.41.41.41.31.31.4-1.5-1.41.4-1.41.1
Reaction time premature initiation rate0.00.00.0-0.10.00.00.0-0.0-0.0-0.0-0.0-0.1-0.00.10.0-0.00.00.1
Reaction time premature initiations0.30.50.50.60.70.70.70.70.70.70.70.60.7-0.7-0.70.7-0.70.7
Std. dev. reaction times6.111.312.4-3.5-3.3-3.3-3.3-3.3-3.4-3.4-3.4-3.3-3.43.53.4-3.43.4-3.0
Reaction time trials completed1.22.22.41.51.51.51.51.41.51.51.51.41.5-1.5-1.51.5-1.51.3
Reaction time trials AUC1.12.12.31.51.51.51.51.41.51.51.41.41.5-1.5-1.51.5-1.51.3
Run reversals in cocaine runway, females0.10.10.5-0.0-0.5-0.5-0.5-0.5-0.3-0.3-0.4-0.5-0.30.10.3-0.30.2-0.7
Run reversals in cocaine runway, males0.80.81.21.10.80.80.80.80.90.90.80.80.9-1.1-1.00.9-1.00.5
Latency to leave start box in cocaine runway5.25.96.62.52.52.52.52.62.42.42.52.52.5-2.3-2.32.3-2.32.3
Latency to leave start box in cocaine runway, F3.94.55.72.12.32.32.32.42.02.12.32.32.1-1.7-1.91.9-1.82.2
Latency to leave start box in cocaine runway, M1.81.72.51.51.21.21.21.21.41.41.21.21.3-1.6-1.41.4-1.40.8
Std. dev. time between licks in bursts5.87.98.22.92.82.82.82.82.92.92.82.82.8-2.8-2.82.8-2.82.6
Total sessions with >9 infusions2.02.43.82.01.61.61.61.61.61.61.61.51.3-1.6-1.51.5-1.51.4
Short access day 1 total inactive lever presses0.50.61.31.10.60.60.60.60.80.80.70.81.0-0.9-0.80.7-0.80.3
Short access day 10 total inactive lever presses0.10.20.30.40.50.50.50.50.40.40.40.40.6-0.4-0.40.4-0.40.4
Short access day 1 total infusions0.50.71.71.30.90.90.90.90.90.90.80.70.6-0.8-0.70.7-0.70.6
Short access day 10 total infusions1.92.43.41.21.41.41.41.41.61.61.71.51.3-1.6-1.71.7-1.71.8
Short access total infusions0.70.91.11.00.90.90.90.91.01.01.00.90.7-1.0-1.01.0-1.01.0
Short access day 1 locomotion0.81.02.21.50.90.90.90.91.11.11.01.00.8-1.1-1.00.9-1.00.6
Short access day 10 total locomotion0.40.70.80.90.80.80.80.80.80.80.80.80.7-0.9-0.90.9-0.90.7
Short access total locomotion1.61.92.91.71.31.31.31.31.51.41.31.31.2-1.6-1.41.4-1.41.0
One hour access (0.3 mA shock)0.30.30.50.30.50.50.50.50.60.60.50.60.5-0.7-0.70.7-0.70.5
Compulsive drug intake0.70.81.10.90.90.90.90.90.90.90.70.71.0-1.1-1.01.0-1.00.5
One hour access (shock baseline)0.00.00.0-0.1-0.1-0.1-0.1-0.10.00.00.10.1-0.10.0-0.00.0-0.00.2
Social response proportion0.91.01.3-1.1-1.1-1.1-1.1-1.0-1.0-1.0-1.1-1.0-1.00.90.9-0.90.9-1.0
Social responses0.00.00.10.1-0.1-0.1-0.10.00.10.10.00.10.1-0.2-0.20.1-0.2-0.1
Social time0.50.71.5-1.2-0.9-0.9-0.9-0.8-0.9-0.9-0.8-0.8-0.80.90.8-0.80.8-0.5
Soleus weight0.30.92.11.40.80.80.80.81.01.00.91.01.1-1.1-0.90.9-0.90.4
Bone: stiffness1.42.24.3-0.8-1.7-1.7-1.7-1.7-1.4-1.4-1.5-1.5-1.31.21.4-1.51.4-2.1
Tibialis anterior weight3.311.114.33.83.23.23.23.23.43.43.43.43.5-3.4-3.33.2-3.32.7
Time to tail flick, vehicle, before self-admin0.40.40.50.50.50.50.50.60.60.60.60.60.6-0.7-0.70.7-0.70.6
Time to tail flick, vehicle, after self-admin0.00.00.2-0.5-0.2-0.2-0.2-0.1-0.2-0.2-0.2-0.2-0.20.20.1-0.10.10.1
Time to tail flick, test, before self-admin1.41.52.31.41.11.11.11.11.31.21.11.11.3-1.5-1.31.3-1.40.7
Time to tail flick, test, after self-admin0.80.82.01.40.80.80.80.91.01.00.90.91.0-0.9-0.80.8-0.80.5
Delta time to tail flick, vehicle, before/after SA0.20.20.4-0.6-0.4-0.4-0.4-0.4-0.5-0.5-0.4-0.4-0.50.60.5-0.50.5-0.2
Delta time to tail flick, test, before/after SA0.20.20.6-0.2-0.3-0.3-0.3-0.3-0.4-0.4-0.3-0.3-0.40.80.7-0.60.7-0.1
Tibia length5.114.016.5-3.1-3.8-3.8-3.8-3.8-3.7-3.7-3.8-3.8-3.73.63.8-3.83.8-4.1
Ambulatory time before self-admin4.66.97.1-2.5-2.6-2.6-2.6-2.6-2.6-2.6-2.6-2.6-2.62.62.7-2.62.7-2.5
Ambulatory time after self-admin1.01.21.3-1.1-1.1-1.1-1.1-1.1-1.1-1.1-1.1-1.1-1.01.11.1-1.11.1-1.1
Bone: tissue strength0.10.10.1-0.2-0.3-0.3-0.3-0.3-0.3-0.3-0.2-0.2-0.20.30.3-0.30.3-0.2
Total heroin consumption0.81.01.8-1.4-0.9-0.9-0.9-0.9-1.1-1.0-1.0-0.9-1.01.11.0-1.01.0-0.6
Bone: trabecular number1.42.42.8-1.6-1.5-1.5-1.5-1.5-1.6-1.6-1.5-1.5-1.61.71.6-1.61.6-1.3
Bone: trabecular spacing0.20.20.50.70.30.30.30.30.50.50.30.30.5-0.7-0.60.5-0.60.0
Bone: trabecular thickness3.24.05.7-2.4-1.9-1.9-1.9-1.9-2.1-2.1-1.9-1.9-2.02.32.1-2.02.1-1.4
Bone: trabecular tissue density0.20.30.7-0.4-0.6-0.6-0.6-0.6-0.5-0.5-0.6-0.6-0.50.30.4-0.40.4-0.8
Water consumed over 24 hours0.40.50.70.60.80.80.80.70.70.70.70.70.7-0.6-0.60.7-0.60.9
Number of responses in last shaping day0.20.20.30.40.50.50.50.50.40.40.40.30.1-0.4-0.40.5-0.40.6