Mzf1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	alternative TSS	XM_006228116.5	0.04	0.03	5.1e-03	0.01	0.01	0.02	0.01	4.0e-02	1.1e-02	7.0e-03	2.5e-02
2	PL	alternative TSS	NM_001108470.1	0.03	0.03	6.3e-03	0.01	0.01	0.01	0.01	4.5e-02	1.5e-02	2.4e-02	3.1e-02
3	PL	isoform ratio	NM_001108470.1	0.04	0.03	8.6e-03	0.02	0.01	0.01	0.01	5.3e-03	2.9e-02	1.5e-02	4.3e-02
4	Liver	gene expression	Mzf1	0.06	0.04	4.2e-06	0.04	0.04	0.04	0.04	1.6e-05	6.7e-05	8.5e-05	2.9e-05
5	PL	isoform ratio	XM_006228116.5	0.04	0.03	7.9e-03	0.01	0.01	0.01	0.01	3.3e-02	2.8e-02	1.5e-02	5.3e-02
6	NAcc	gene expression	Mzf1	0.08	0.06	1.5e-04	0.03	0.02	0.04	0.03	1.5e-05	1.3e-04	1.8e-06	3.3e-05
7	Brain	gene expression	Mzf1	0.27	0.16	7.3e-05	0.05	0.04	0.07	0.04	3.5e-05	7.4e-05	5.6e-07	5.4e-05
8	Adipose	gene expression	Mzf1	0.21	0.1	1.7e-11	0.09	0.07	0.07	0.08	5.3e-10	2.8e-08	1.5e-08	2.9e-09
9	pVTA	gene expression	Mzf1	0.13	0.08	1.7e-04	0.04	0.05	0.03	0.04	4.2e-04	1.2e-04	3.5e-03	8.1e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	0.2	0.4	1.2	-0.5	-0.6	0.1	-0.1	-0.8	-0.5	-0.8	-0.8	1.1
Area under the delay curve	0.8	1.2	1.9	1.3	1.2	-1.0	0.9	1.0	1.4	1.1	1.1	-1.0
BMI with tail	0.4	1.6	3.9	0.3	0.7	1.2	1.6	-0.2	2.0	1.0	1.2	-1.7
BMI without tail	0.2	1.1	4.5	-0.9	-0.4	2.1	-0.0	-0.5	0.9	0.3	0.4	-1.7
Body weight	1.1	4.8	13.5	-3.0	-2.5	3.7	-2.0	-2.2	-1.0	-1.5	-1.4	-0.2
Weight adjusted by age	0.3	0.9	1.9	-1.2	-1.2	1.3	-0.7	-1.4	-0.6	-0.6	-0.6	0.5
Bone surface	3.5	7.0	8.6	-2.8	-2.9	1.9	-2.3	-2.8	-2.5	-2.9	-2.9	2.6
Bone volume	2.8	5.6	7.9	-2.4	-2.5	1.4	-2.1	-2.4	-2.1	-2.8	-2.7	2.5
Breakpoint value in progressive ratio session	2.1	3.9	9.3	2.2	2.2	-2.0	0.7	3.1	1.0	1.9	1.5	-2.1
Number of licking bursts	0.1	0.3	1.4	-0.6	-0.3	1.2	-0.1	-0.7	0.4	-0.0	0.1	-0.7
Context. condit. distance diff. score	0.1	0.1	0.2	-0.3	-0.2	0.5	0.4	-0.4	-0.5	0.2	0.0	0.1
Locomotion velocity, session 1	0.2	0.2	0.9	-0.2	-0.4	-0.4	-0.6	-0.4	-1.0	0.0	-0.2	0.7
Locomotion distance, session 1	1.6	2.0	3.7	-1.5	-1.8	0.8	-1.9	-1.2	-1.7	-1.0	-1.1	1.3
Locomotion velocity, session 2	0.5	0.6	1.6	-1.0	-0.8	1.2	-0.1	-1.2	-0.5	-0.2	-0.2	0.4
Locomotion distance, session 2	2.0	2.9	4.4	-2.1	-2.0	1.7	-1.8	-1.7	-1.5	-1.5	-1.5	1.3
Locomotion velocity, session 3	0.2	0.2	0.4	-0.5	-0.4	0.4	-0.1	-0.7	-0.4	-0.4	-0.4	0.4
Locomotion distance, session 3	1.3	1.5	3.7	-1.0	-1.1	0.4	-0.3	-1.5	-1.6	-1.1	-1.2	1.9
Stereotopy head waving bouts, day 3	0.5	0.6	2.3	0.4	0.6	0.0	0.1	0.6	0.8	1.0	0.9	-1.5
Stereotopy head waving duration, day 3	0.8	1.0	2.7	0.7	0.8	-0.2	0.0	1.1	0.9	1.2	1.2	-1.7
Locomotion velocity, session 7	0.3	0.3	1.1	0.3	0.0	-1.0	-0.6	0.8	-0.6	-0.1	-0.3	0.6
Locomotion distance, session 7	0.0	0.0	0.1	-0.0	-0.2	-0.2	-0.3	0.1	-0.3	-0.2	-0.3	0.2
Stereotopy head waving bouts, day 7	0.4	0.5	1.0	-1.0	-0.8	0.8	-0.4	-0.7	-0.9	-0.5	-0.5	0.6
Stereotopy head waving duration, day 7	0.2	0.3	0.6	-0.8	-0.6	0.7	-0.4	-0.5	-0.5	-0.3	-0.3	0.2
Locomotion velocity, session 8	0.0	0.0	0.1	-0.0	-0.2	-0.0	-0.2	0.3	-0.4	-0.0	-0.1	0.1
Locomotion distance, session 8	0.5	0.8	1.2	-1.1	-1.0	0.9	-0.5	-1.0	-1.1	-0.5	-0.6	0.8
Degree of sensitization distance	0.6	0.7	1.9	0.6	0.7	-0.3	-0.1	1.1	0.9	0.8	0.8	-1.4
Degree of sensitization stereotypy	1.1	1.3	2.3	-1.4	-1.1	1.3	0.1	-1.5	-1.1	-0.9	-0.9	1.2
Conditioned locomotion	0.1	0.1	0.2	-0.1	-0.1	0.4	-0.0	0.0	-0.1	0.5	0.3	-0.4
Cocaine response after cond. corrected	0.4	0.6	1.2	0.7	1.0	-0.5	0.5	1.1	0.9	0.6	0.7	-0.9
Cocaine response after cond. not corrected	0.2	0.2	0.5	-0.7	-0.5	0.7	-0.7	-0.2	-0.2	-0.5	-0.4	-0.0
Cocaine response before conditioning	5.6	6.8	10.3	-3.1	-3.2	2.8	-2.3	-3.1	-2.1	-2.4	-2.2	1.7
Saline control response	1.4	2.0	4.2	-1.7	-1.6	1.8	-0.5	-2.0	-0.8	-1.1	-1.0	1.2
Bone: connectivity density	0.2	0.4	1.2	-0.4	-0.4	0.3	0.5	-1.0	-0.4	-0.3	-0.4	1.1
Bone: cortical apparent density	0.3	0.5	1.3	0.7	0.6	-0.8	-0.4	1.2	0.8	0.3	0.3	-0.8
Bone: cortical area	1.0	1.6	3.4	-1.5	-1.5	1.5	-1.0	-1.8	-0.6	-1.0	-0.9	0.8
Bone: cortical porosity	0.3	0.3	0.5	0.5	0.5	-0.2	0.7	0.5	0.3	0.6	0.5	-0.7
Bone: cortical porosity	0.1	0.1	0.2	0.0	0.2	0.2	0.4	0.1	0.1	0.2	0.3	-0.5
Bone: cortical thickness	0.3	0.6	1.4	0.7	0.7	-0.2	0.6	0.4	1.2	0.8	0.8	-0.9
Bone: cortical thickness	0.2	0.2	0.4	-0.6	-0.6	0.7	-0.5	-0.4	-0.1	-0.5	-0.5	0.1
Bone: cortical tissue density	0.3	0.5	1.4	0.7	0.7	-0.8	-0.4	1.2	0.8	0.2	0.3	-0.7
Condit. Reinf. active minus inactive responses	0.2	0.2	1.0	-0.0	0.1	0.5	-0.0	0.3	0.5	0.2	0.3	-1.0
Condit. Reinf. active-inactive response ratio	0.9	1.0	2.3	0.6	0.8	0.3	1.1	0.5	1.3	1.0	1.1	-1.5
Condit. Reinf. active responses	0.2	0.3	0.6	-0.7	-0.6	0.6	-0.8	-0.2	-0.5	-0.6	-0.6	-0.0
Condit. Reinf. inactive responses	1.7	2.3	4.1	-1.3	-1.5	0.2	-1.9	-0.7	-2.0	-1.6	-1.7	1.7
Incentive salience index mean	0.2	0.2	0.6	-0.5	-0.5	0.8	-0.6	-0.1	-0.0	-0.3	-0.3	-0.5
Condit. Reinf. lever presses	0.3	0.5	1.1	-0.8	-0.9	0.8	-1.0	-0.4	-0.5	-0.7	-0.7	-0.0
Condit. Reinf. active minus inactive responses	2.3	3.5	4.7	-1.8	-2.0	0.9	-2.0	-1.6	-2.2	-2.0	-2.0	2.1
Condit. Reinf. active-inactive response ratio	2.0	3.2	4.3	-1.8	-2.0	0.8	-1.9	-1.4	-2.1	-1.9	-1.8	2.0
Condit. Reinf. active responses	2.3	3.3	4.5	-1.7	-2.0	0.8	-1.9	-1.6	-2.1	-1.9	-1.9	2.0
Condit. Reinf. inactive responses	0.0	0.0	0.1	0.1	-0.2	0.0	-0.1	-0.2	-0.3	-0.2	-0.3	0.1
Condit. Reinf. lever presses	0.2	0.4	1.2	-0.7	-0.6	0.9	-0.0	-1.1	-0.4	-0.3	-0.2	0.3
Condit. Reinf. lever reinforcers received	3.3	4.7	6.2	-2.0	-2.4	1.1	-2.1	-2.0	-2.5	-2.3	-2.3	2.4
Conditioned reinforcement - actives	0.1	0.5	1.7	-0.7	-0.3	1.0	-0.7	0.6	-0.2	0.1	0.1	-1.3
Conditioned reinforcement - inactives	0.4	1.0	3.1	-1.1	-1.1	0.8	-1.8	0.3	-1.2	-0.7	-0.9	-0.4
Conditioned locomotion	0.2	0.3	1.4	-0.0	0.2	0.1	-0.3	0.8	0.1	0.2	0.3	-1.2
Patch foraging indifference point 0 sec	0.3	0.9	1.9	0.8	0.8	-0.3	1.0	0.4	0.8	1.4	1.2	-1.2
Patch foraging indifference point AUC	0.4	0.9	3.0	-0.8	-0.2	1.7	0.9	-1.1	1.2	0.4	0.8	-0.7
Delay disc. indifference point, 0s delay	0.2	0.2	0.9	0.0	-0.4	-0.1	0.3	-1.0	0.1	-0.2	-0.1	0.9
Delay disc. indifference point, 16s delay	1.2	1.7	2.7	1.4	1.6	-1.3	0.8	1.6	1.6	0.7	0.9	-1.2
Delay disc. indifference point, 2s delay	0.7	0.8	1.6	1.1	0.9	-0.8	0.5	1.3	0.8	0.9	0.8	-0.9
Delay disc. indifference point, 24s delay	0.6	0.9	1.7	0.8	1.0	-0.3	0.7	1.0	1.3	0.8	0.9	-1.3
Delay disc. indifference point, 4s delay	0.1	0.1	0.3	-0.4	-0.4	0.3	-0.2	-0.5	0.2	-0.5	-0.4	0.2
Delay disc. indifference point, 8s delay	1.1	1.9	2.6	1.6	1.4	-1.3	0.9	1.6	1.1	1.6	1.3	-1.3
Indifference point function ln k	1.1	3.4	9.4	-0.8	-1.6	-0.7	-3.1	0.4	-2.8	-1.5	-2.1	1.6
Indifference point function log k	1.1	3.4	9.4	-0.8	-1.6	-0.7	-3.1	0.4	-2.8	-1.5	-2.1	1.6
Patch foraging total patch changes 0 sec	0.3	1.0	2.0	0.8	0.9	-0.2	1.0	0.5	0.9	1.4	1.2	-1.4
Patch foraging total patch changes 12 sec	0.4	0.5	1.1	-0.4	0.0	1.0	0.9	-0.9	0.9	0.3	0.6	-0.5
Patch foraging total patch changes 18 sec	0.4	0.8	1.5	-0.4	0.1	1.2	1.2	-1.2	1.0	0.7	1.0	-0.6
Patch foraging total patch changes 24 sec	0.3	0.9	2.3	-1.3	-0.7	1.4	0.3	-1.5	0.1	-0.8	-0.3	0.5
Patch foraging total patch changes 6 sec	0.7	1.2	2.4	0.6	0.9	0.4	1.3	0.1	1.5	1.2	1.3	-1.6
Patch foraging time to switch 0 sec	1.1	4.1	7.1	2.5	2.7	-2.6	1.8	2.6	1.8	1.0	1.2	-0.9
Patch foraging water rate 0 sec	0.5	1.9	4.5	-1.8	-1.7	2.1	-0.7	-2.1	-0.8	-0.4	-0.5	0.4
Patch foraging water rate 12 sec	0.2	0.9	2.7	-0.7	-1.3	0.5	-1.7	-0.5	-1.4	-0.3	-0.7	0.4
Patch foraging water rate 18 sec	0.1	0.3	0.8	0.0	-0.4	-0.1	-0.9	0.5	-0.9	0.4	-0.1	-0.3
Patch foraging water rate 24 sec	0.4	0.6	1.7	-0.6	-0.9	0.0	-1.0	-0.5	-1.3	-0.4	-0.7	0.9
Patch foraging water rate 6 sec	6.3	9.2	13.6	-3.7	-3.6	3.1	-3.2	-3.1	-2.9	-2.7	-2.7	2.0
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.5	0.6	0.0	-0.7	0.3	0.1	-0.5	0.6	0.2	0.7
Distance traveled before self-admin	0.3	0.7	1.5	-0.8	-1.2	0.6	-1.1	-1.0	-1.2	-0.2	-0.6	0.4
Distance traveled after self-admin	0.3	0.5	1.3	0.8	0.4	-0.5	0.9	-0.2	0.3	1.2	0.9	0.1
Extensor digitorum longus weight	0.6	2.2	7.3	-2.0	-1.6	2.7	-0.6	-2.0	-0.3	-1.0	-0.8	-0.0
Bone: elastic displacement	1.7	2.2	3.9	2.0	1.7	-1.9	1.0	1.3	0.9	1.7	1.4	-1.0
Bone: elastic work	0.0	0.0	0.1	0.3	0.0	-0.2	-0.2	-0.3	-0.1	0.2	0.0	-0.1
Bone: endosteal estimation	2.8	6.8	8.8	-2.8	-2.9	1.6	-2.2	-2.3	-3.0	-2.8	-2.8	2.7
Bone: endosteal perimeter	1.4	3.4	4.3	-1.9	-2.1	1.0	-1.8	-1.9	-2.1	-1.9	-1.9	2.0
Epididymis fat weight	0.1	0.4	1.4	0.7	0.7	-1.2	0.2	1.0	0.2	-0.1	-0.2	0.2
Delta time in closed arm before/after self-admin	0.1	0.1	0.5	-0.1	-0.2	0.0	0.3	-0.1	0.4	-0.4	-0.1	0.7
Delta time in open arm before/after self-admin	0.4	0.5	1.7	-0.7	-0.7	0.6	-1.3	-0.4	-1.0	-0.2	-0.5	-0.5
Diff in mean of infusions in LGA sessions	0.5	0.9	2.4	1.1	0.8	-1.0	-0.0	1.6	0.2	1.1	0.7	-1.1
Delay discount exponential model param	0.8	1.1	1.6	-1.2	-1.1	0.8	-0.8	-1.0	-1.3	-1.0	-1.0	1.1
Extinction: sum of active levers before priming	0.2	0.2	0.9	-0.3	-0.4	0.4	0.3	-0.9	0.1	-0.4	-0.2	0.7
Active lever presses in extinction session 6	0.3	0.3	1.0	-0.7	-0.2	1.0	0.0	-0.2	0.5	-0.5	-0.2	-0.5
Bone: final force	2.4	3.9	5.5	-2.3	-2.3	2.1	-1.9	-2.2	-1.3	-2.1	-1.9	1.3
Bone: final moment	3.1	5.0	6.9	-2.6	-2.6	2.3	-2.1	-2.5	-1.7	-2.3	-2.1	1.6
Food consumed during 24 hour testing period	0.4	0.8	2.7	0.9	0.3	-1.7	-1.1	1.4	-0.4	0.0	-0.3	0.1
Glucose	2.8	4.4	7.1	2.7	2.3	-2.3	1.7	2.6	1.8	2.0	1.8	-1.6
Heart weight	0.3	0.4	1.3	-0.5	-0.5	0.8	-1.2	0.1	0.4	-0.4	-0.3	-0.8
Delay discount hyperbolic model param	0.9	1.2	1.8	-1.2	-1.1	0.7	-0.9	-1.0	-1.4	-1.1	-1.1	1.2
Intermittent access intake day 1-15 change	0.1	0.4	1.3	-0.6	-0.5	0.7	-1.1	0.5	-0.5	-0.3	-0.4	-0.6
Intermittent access intake escalation	0.1	0.6	2.0	-0.9	-0.7	0.9	-1.4	0.4	-0.7	-0.5	-0.6	-0.6
Intermittent access intake escalation 2	0.1	0.1	0.4	0.0	-0.0	0.2	-0.5	0.6	-0.0	0.4	0.2	-0.7
Intermitt. access day 1 inactive lever presses	0.1	0.8	2.5	-0.4	-0.2	0.3	-1.6	1.4	-0.8	-0.1	-0.4	-1.3
Intermitt. access day 15 inactive lever presses	0.3	1.5	3.1	-1.4	-1.3	1.1	-1.8	0.0	-1.4	-1.2	-1.2	0.1
Intermitt. access escalation Index	0.3	0.9	2.0	0.9	1.0	-0.4	0.8	0.5	1.4	0.8	1.0	-1.2
Intermittent access day 1 total infusions	0.1	0.4	0.7	-0.8	-0.6	0.7	-0.7	-0.1	-0.7	-0.5	-0.5	-0.2
Intermittent access day 15 total infusions	0.3	0.7	2.4	-0.3	-0.0	0.3	-1.3	1.6	-0.4	0.1	-0.1	-1.5
Intermittent access terminal intake (last 3 days)	0.3	0.6	2.1	-0.3	-0.2	0.2	-1.2	1.4	-0.7	0.1	-0.2	-1.1
Intermittent access total infusions	0.6	0.7	2.0	-0.9	-0.6	0.7	-1.4	0.8	-1.1	-0.3	-0.6	-0.8
Intermittent access day 1 locomotion	0.3	0.5	1.4	-0.3	-0.3	-0.3	-1.2	0.9	-0.9	-0.6	-0.7	-0.1
Intermittent access day 15 total locomotion	0.2	0.7	2.6	0.2	0.1	-0.3	-1.2	1.6	-0.6	0.6	0.1	-1.4
Intermittent access total locomotion	1.0	1.2	4.0	-0.9	-0.9	0.2	-2.0	0.8	-1.6	-0.8	-1.1	-0.2
Intermittent access standard deviation	0.4	2.2	5.0	1.3	1.3	-0.7	0.4	2.2	0.8	1.7	1.4	-2.1
Left kidney weight	2.6	21.0	38.0	-6.0	-5.5	6.2	-4.8	-4.4	-3.6	-3.8	-3.6	1.3
Right kidney weight	2.5	17.5	29.9	-5.5	-5.0	5.4	-4.7	-3.9	-3.2	-3.6	-3.4	1.2
Cocaine induced anxiety	0.3	0.8	1.9	-0.6	-0.7	-0.2	-1.4	-0.1	-1.1	-1.0	-1.1	0.9
Post-drug Anxiety	0.7	0.8	1.4	-0.6	-0.6	-0.2	-1.1	-0.2	-1.1	-1.2	-1.2	1.1
Baseline Anxiety	0.3	0.4	1.1	0.9	0.8	-1.0	0.9	0.3	0.5	0.3	0.4	0.3
Tail length	1.4	7.5	12.3	-3.5	-3.2	3.3	-3.4	-2.2	-2.7	-2.1	-2.3	0.7
Length with tail	2.2	9.5	14.2	-3.8	-3.6	3.1	-3.7	-2.5	-3.1	-2.9	-2.9	1.7
Length without tail	0.9	4.5	6.4	-2.5	-2.3	1.8	-2.4	-1.8	-1.7	-2.5	-2.2	1.6
Times rat made contact with spout	0.2	0.3	0.8	0.7	0.6	-0.9	0.6	0.4	0.2	0.4	0.2	0.2
Lifetime Intake	0.5	0.6	1.3	-1.0	-0.7	1.0	-1.2	0.4	-0.9	-0.4	-0.6	-0.6
Liver weight, left	2.5	4.3	12.2	-2.8	-2.2	3.5	-1.6	-2.6	-0.7	-1.4	-1.2	-0.2
Liver weight, right	0.4	0.7	3.1	-0.8	-0.5	1.8	0.1	-1.0	0.4	0.1	0.2	-0.9
Locomotor activity	0.3	0.5	1.5	-0.3	-0.1	1.2	0.8	-0.5	0.7	0.3	0.5	-0.8
Locomotor testing distance	0.1	0.3	1.6	-0.7	-0.5	1.2	0.2	-0.7	0.1	-0.3	-0.0	-0.2
Locomotor testing rearing	0.9	3.3	11.3	-2.5	-1.9	3.4	-0.2	-2.6	-0.4	-0.9	-0.5	0.3
Locomotion in novel chamber	1.0	1.3	4.2	1.6	1.4	-2.0	1.0	1.1	0.6	0.6	0.6	0.2
Locomotion in novel chamber post-restriction	0.3	1.0	2.1	1.4	1.1	-1.4	1.0	0.7	1.0	0.8	0.7	0.1
Fecal boli incidents, locomotor time 1	0.0	0.0	0.1	-0.1	-0.2	-0.1	-0.3	-0.0	-0.2	0.2	0.1	0.0
Change in fecal boli incidents, locomotor task	2.3	2.4	3.1	1.8	1.8	-1.2	1.6	1.6	1.6	1.6	1.6	-1.2
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.8	0.6	0.6	-0.5	0.3	0.9	0.3	0.2	0.1	-0.5
Bouts of movement, locomotor time 1	0.1	0.1	0.5	0.5	0.0	-0.7	-0.3	0.4	-0.1	0.5	0.2	0.2
Total resting periods, locomotor time 1	0.5	0.5	2.0	1.0	0.6	-1.4	0.1	1.0	0.2	0.5	0.4	0.2
Rest time, locomotor task time 1	0.6	0.9	2.4	-0.6	-0.9	-0.2	-1.0	-0.6	-0.6	-1.3	-1.1	1.5
Distance moved, locomotor task time 1	0.3	0.7	1.7	0.4	0.7	0.6	1.0	-0.0	0.9	1.0	1.0	-1.3
Vertical activity count, locomotor time 1	0.4	2.4	4.8	1.3	1.4	0.0	1.8	0.6	1.5	2.2	1.9	-2.0
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.6	0.4	0.6	-0.3	0.8	0.3	0.6	0.1	0.3	-0.1
Bouts of movement, locomotor time 2	0.2	0.6	2.5	0.9	0.4	-1.6	0.1	0.7	-0.2	-0.4	-0.4	1.0
Total resting periods, locomotor time 2	0.2	0.7	2.9	0.8	0.3	-1.7	0.0	0.5	-0.3	-0.5	-0.6	1.3
Rest time, locomotor task time 2	0.2	0.3	1.4	0.5	0.0	-1.1	0.1	0.1	-0.3	-0.1	-0.2	1.2
Distance moved, locomotor task time 2	0.4	0.6	2.4	-0.8	-0.4	1.5	0.3	-1.2	0.3	0.0	0.1	-0.5
Vertical activity count, locomotor time 2	0.2	0.4	1.2	-0.3	-0.2	1.1	0.6	-0.8	0.3	0.5	0.5	-0.7
Light reinforcement 1	0.1	0.5	1.8	-0.7	-0.7	1.0	0.1	-1.3	-0.4	-0.2	-0.2	0.1
Light reinforcement 2	0.2	0.5	1.2	0.2	0.5	0.6	1.0	-0.2	1.0	0.6	0.8	-1.1
Bone: marrow area	2.8	6.9	8.9	-2.8	-2.9	1.7	-2.2	-2.4	-3.0	-2.8	-2.8	2.8
Bone: maximum diameter	1.4	2.8	6.2	-2.2	-1.9	2.5	-1.1	-2.4	-0.7	-1.1	-0.9	0.6
Bone: maximum force	1.8	3.6	5.0	-2.1	-2.2	1.7	-1.9	-2.0	-1.5	-2.1	-2.0	1.4
Bone: maximum moment	2.4	4.5	6.2	-2.3	-2.5	1.9	-2.0	-2.3	-1.8	-2.2	-2.2	1.7
Mean time between licks in bursts	0.1	0.7	1.5	0.8	0.8	-0.1	0.9	0.5	1.0	1.0	0.9	-1.2
Mean num. licks in bursts	0.2	0.7	2.8	1.0	0.5	-1.7	0.3	0.9	-0.3	0.1	-0.1	0.9
Cd content in liver	0.7	0.8	2.1	-0.6	-0.9	-0.2	-1.4	-0.4	-0.9	-1.0	-0.9	1.1
Co content in liver	0.3	0.4	1.8	-0.2	-0.5	-0.4	-1.3	0.4	-0.4	-0.6	-0.5	0.5
Cu content in liver	2.1	2.5	3.8	-2.0	-1.8	1.4	-1.6	-1.4	-1.4	-1.8	-1.6	1.1
Fe content in liver	1.1	1.3	3.8	-1.7	-1.2	2.0	-1.0	-1.3	-0.3	-0.9	-0.7	-0.1
K content in liver	0.5	0.5	1.4	-1.1	-0.8	1.2	-0.3	-1.1	-0.3	-0.2	-0.1	0.2
Mg content in liver	0.3	0.3	1.4	-0.9	-0.5	1.2	-0.0	-0.8	-0.0	-0.0	0.2	-0.1
Mn content in liver	0.0	0.1	0.2	-0.3	-0.0	0.5	0.2	-0.0	-0.0	0.0	0.1	-0.4
Na content in liver	0.4	0.5	1.4	0.4	0.6	0.0	1.2	0.2	0.6	0.9	0.9	-0.6
Rb content in liver	2.6	3.1	5.3	-2.0	-2.0	1.1	-1.8	-1.1	-2.3	-1.7	-1.8	1.6
Se content in liver	1.8	2.1	4.8	-0.4	0.4	2.2	1.7	-0.9	1.5	1.3	1.5	-2.1
Sr content in liver	6.0	5.2	7.5	2.5	2.4	-1.3	2.7	1.5	2.4	2.7	2.6	-2.1
Zn content in liver	0.3	0.4	1.6	-0.6	-0.0	1.3	0.3	-0.6	0.7	0.0	0.4	-0.8
Bone: minimum diameter	3.2	6.1	9.0	-2.8	-2.8	2.0	-2.1	-3.0	-2.3	-2.3	-2.2	2.5
Time in familiar zone, hab. session 1	2.0	2.2	3.2	-1.4	-1.8	0.9	-1.5	-1.5	-1.6	-1.4	-1.6	1.4
Time in novel zone, hab. session 1	0.5	0.6	1.3	0.3	0.8	0.4	0.9	0.3	1.1	0.7	1.0	-1.0
Total zone transitions, hab. session 1	1.8	2.6	3.7	-1.7	-1.9	0.9	-1.3	-1.5	-1.9	-1.4	-1.5	1.9
Total locomotion distance, hab. session 1	0.2	0.2	0.8	-0.2	-0.5	-0.2	-0.4	-0.4	-0.8	-0.0	-0.3	0.9
Locomotion velocity, hab. session 1	0.2	0.3	0.7	0.2	-0.1	-0.8	-0.3	0.2	-0.8	0.1	-0.2	0.8
Time in familiar zone, hab. session 2	1.3	1.4	2.7	-0.9	-1.1	0.1	-1.5	-0.6	-1.3	-1.6	-1.7	1.2
Time in novel zone, hab. session 2	0.4	0.5	1.0	0.4	0.6	0.2	1.0	0.3	0.8	0.8	1.0	-0.6
Total zone transitions, hab. session 2	2.3	2.9	4.7	-2.1	-2.2	1.6	-1.5	-1.9	-1.9	-1.0	-1.1	1.6
Total locomotion distance, hab. session 2	0.1	0.2	0.7	0.4	0.1	-0.4	0.2	-0.1	-0.2	0.8	0.6	0.3
Locomotion velocity, hab. session 2	0.2	0.2	1.0	0.4	0.2	-0.3	0.3	-0.1	-0.1	1.0	0.8	0.1
Novel to familiar place preference ratio	0.2	0.3	1.1	-0.5	-0.3	1.0	0.3	-0.8	0.1	0.3	0.3	-0.3
Novelty place preference	0.2	0.3	1.1	-0.7	-0.6	1.0	-0.0	-0.8	-0.2	-0.1	-0.0	-0.1
Time in novel zone, NPP test	0.3	0.3	1.2	-0.8	-0.6	1.1	-0.1	-0.8	-0.2	-0.2	-0.1	-0.0
Total zone transitions, NPP test	0.1	0.2	0.4	-0.5	-0.6	0.6	-0.3	-0.6	-0.3	-0.2	-0.2	0.2
Total locomotion distance, NPP test	0.1	0.2	0.7	0.1	0.0	0.2	0.2	-0.4	0.3	0.8	0.7	-0.3
Locomotion velocity, NPP test	0.1	0.2	0.5	-0.1	-0.1	0.3	0.1	-0.6	0.1	0.7	0.6	-0.2
Intraocular pressure	0.1	0.1	0.3	-0.2	-0.1	-0.3	-0.2	0.1	-0.4	-0.4	-0.4	0.6
Delta distance traveled before/after self-admin	1.8	2.0	2.9	1.6	1.6	-0.9	1.7	1.2	1.3	1.7	1.6	-1.1
Delta ambulatory time before/after self-admin	1.3	2.2	3.0	1.6	1.6	-0.9	1.5	1.3	1.5	1.7	1.6	-1.4
Parametrial fat weight	2.7	6.2	8.1	2.7	2.7	-1.8	2.4	2.3	2.6	2.8	2.6	-2.3
Pavlov. Cond. lever latency	0.2	0.2	1.0	0.6	0.4	-1.0	0.0	0.5	-0.1	0.1	-0.0	0.4
Pavlov. Cond. magazine entry latency	0.5	0.6	1.4	0.1	0.4	0.8	1.2	-0.3	1.1	0.8	1.0	-0.8
Pavlov. Cond. change in total contacts	0.1	0.2	0.2	0.4	0.4	-0.2	0.5	0.4	0.4	0.5	0.5	-0.4
Pavlov. Cond. index score	0.3	0.4	1.1	-0.2	0.0	1.1	0.7	-0.4	0.7	0.5	0.6	-0.8
Pavlov. Cond. latency score	0.3	0.3	0.6	0.0	0.2	0.7	0.7	-0.1	0.8	0.6	0.7	-0.8
Pavlov. Cond. lever contacts	0.1	0.2	0.8	-0.5	-0.4	0.9	0.0	-0.4	0.0	-0.1	-0.1	-0.3
Pavlov. Cond. magazine entry number	0.2	0.3	1.0	0.3	0.1	-1.0	-0.8	0.6	-0.4	-0.4	-0.4	0.2
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.4	0.0	-0.2	-0.4	-0.4	-0.2	-0.6	-0.2	-0.3	0.4
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	1.1	-0.2	0.0	1.1	0.7	-0.4	0.7	0.6	0.7	-0.8
Pavlov. Cond. response bias	0.5	0.6	2.6	-0.9	-0.5	1.6	0.5	-1.0	0.2	-0.1	0.1	-0.3
Pavlov. Cond. lever latency	0.5	0.7	1.9	-0.7	-0.6	-0.1	-1.4	0.3	-0.7	-1.2	-1.2	0.6
Pavlov. Cond. magazine entry latency	1.0	1.4	2.5	1.1	1.2	-0.3	1.6	0.5	1.2	1.5	1.4	-1.1
Pavlov. Cond. change in total contacts	0.0	0.1	0.4	0.2	-0.1	-0.4	0.2	-0.3	-0.4	-0.0	-0.2	0.7
Pavlov. Cond. index score	0.2	0.3	1.0	0.5	0.4	0.0	1.0	-0.3	0.4	0.8	0.7	-0.3
Pavlov. Cond. latency score	0.6	1.0	2.0	1.1	1.0	-0.4	1.4	0.3	0.8	1.3	1.2	-0.8
Pavlov. Cond. lever contacts	0.3	0.4	1.1	0.2	0.3	0.4	1.1	-0.7	0.4	0.9	0.9	-0.4
Pavlov. Cond. magazine entry number	0.5	0.7	1.5	-1.0	-1.0	0.7	-1.2	-0.4	-0.7	-0.9	-0.7	0.4
Pavlov. Cond. intertrial magazine entries	2.3	5.0	6.6	-2.3	-2.5	1.2	-2.6	-1.9	-2.3	-2.5	-2.3	2.2
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	1.1	0.4	0.4	0.1	1.1	-0.3	0.5	0.8	0.7	-0.4
Pavlov. Cond. response bias	0.1	0.2	1.0	-0.3	-0.3	0.5	0.5	-1.0	-0.2	0.1	0.1	0.3
Time in closed arm before self-admin	0.2	0.4	1.4	-0.0	-0.0	-0.0	-1.0	0.8	-0.7	0.4	0.0	-1.2
Time in closed arm after self-admin	0.1	0.1	0.4	0.2	0.1	-0.6	-0.4	0.6	-0.4	-0.1	-0.3	0.2
Time in open arm before self-admin	0.5	0.6	2.5	0.6	0.5	-0.3	1.6	-0.6	1.1	0.1	0.5	0.9
Time in open arm after self-admin	0.1	0.1	0.8	0.0	-0.0	0.2	0.5	-0.9	0.2	-0.0	0.1	0.4
Bone: periosteal estimation	2.4	5.8	7.7	-2.7	-2.8	2.0	-1.9	-2.8	-2.2	-2.4	-2.3	2.4
Bone: periosteal perimeter	2.8	5.5	8.5	-2.5	-2.6	1.7	-1.7	-2.9	-2.0	-2.5	-2.3	2.6
Bone: post-yield work	2.1	3.6	6.1	-1.7	-1.9	0.6	-1.8	-1.1	-2.0	-2.5	-2.4	2.3
Progressive ratio test 1 active lever presses	0.5	0.9	1.5	-1.2	-1.2	1.2	-0.8	-1.1	-0.8	-0.7	-0.7	0.3
Progressive ratio test 1 breakpoint	0.4	0.7	1.2	-1.1	-1.1	1.1	-0.8	-1.0	-0.7	-0.6	-0.6	0.3
Progressive ratio test 1 inactive lever presses	0.9	2.3	3.8	-2.0	-1.8	1.7	-2.0	-0.8	-1.6	-1.3	-1.4	0.2
Progressive ratio test 2 active lever presses	0.3	0.5	1.7	-0.6	-0.3	0.9	-0.8	0.7	-0.2	0.1	0.0	-1.3
Progressive ratio test 2 breakpoint	0.4	0.5	1.5	-0.8	-0.4	1.0	-0.9	0.6	-0.3	-0.0	-0.1	-1.2
Progressive ratio test 2 inactive lever presses	0.7	2.2	4.9	-1.9	-1.7	1.6	-2.2	-0.2	-1.8	-1.0	-1.3	-0.1
Incentive Sensitization - Responses	0.2	0.6	2.0	-0.7	-0.4	0.7	-1.4	1.0	-0.4	-0.3	-0.3	-1.2
Incentive Sensitization - Breakpoint	0.2	0.6	1.7	-0.6	-0.2	0.6	-1.2	1.0	-0.3	-0.1	-0.1	-1.3
Sum of active levers in priming session hrs 5-6	0.8	0.7	1.2	1.0	0.9	-0.7	0.2	0.9	0.6	1.1	0.8	-1.1
Progressive ratio	0.0	0.1	0.2	0.1	-0.0	0.0	0.3	-0.5	-0.0	0.3	0.2	0.2
Food seeking constrained by brief footshock	0.4	0.5	2.0	0.9	0.0	-0.7	0.6	-0.4	0.1	1.4	0.9	0.3
Seeking ratio, punishment vs. effort	0.0	0.1	0.3	0.0	-0.4	-0.3	-0.5	0.1	-0.5	-0.1	-0.3	0.4
Retroperitoneal fat weight	3.6	16.3	22.3	4.3	4.7	-2.8	4.4	3.5	4.6	3.9	4.0	-3.7
Reaction time number correct	0.2	0.7	2.8	-0.5	-0.3	1.4	0.9	-1.7	0.2	0.6	0.5	-0.3
Reaction time mean minus median	0.0	0.1	0.5	0.1	0.2	-0.6	-0.1	0.7	-0.3	-0.1	-0.2	0.4
Reaction time mean minus median AUC	0.0	0.2	0.5	-0.4	-0.2	0.0	-0.0	-0.3	-0.3	-0.5	-0.4	0.7
Reaction time num false alarms	0.7	1.2	5.6	-1.2	-0.6	2.4	0.1	-1.1	0.4	0.3	0.6	-1.4
Reaction time num false alarms AUC	0.5	1.1	4.3	-0.9	-0.4	2.1	0.5	-1.0	0.6	0.6	0.8	-1.4
Reaction time trials correct on left	0.2	0.7	2.8	-0.5	-0.3	1.4	0.9	-1.7	0.2	0.6	0.5	-0.3
Reaction time trials on left	0.2	0.7	2.8	-0.5	-0.3	1.4	0.9	-1.7	0.2	0.6	0.6	-0.3
Reaction time mean	0.4	1.0	3.1	0.1	0.0	-1.1	-1.2	1.8	-1.2	-0.7	-0.9	0.5
Reaction time mean AUC	0.3	0.8	4.1	0.4	0.4	-1.2	-0.8	2.0	-0.8	-0.3	-0.5	0.1
Median of all reaction times	0.6	1.0	3.4	0.1	0.1	-1.1	-1.2	1.8	-1.1	-0.6	-0.9	0.3
Reaction time omissions	0.1	0.1	0.2	0.1	0.2	0.1	0.0	0.4	0.0	0.5	0.4	-0.4
Reaction time false alarm rate	0.2	0.3	1.3	-0.2	0.0	0.8	0.0	0.2	0.4	0.4	0.5	-1.1
Reaction time premature initiation rate	1.0	1.5	4.5	1.6	1.2	-2.0	0.2	2.1	0.3	0.9	0.6	-0.3
Reaction time premature initiations	0.3	1.0	1.8	1.3	1.1	-1.2	0.7	1.2	0.5	1.1	0.9	-0.4
Std. dev. reaction times	0.1	0.4	2.0	0.1	0.2	-0.8	-0.7	1.4	-0.8	-0.2	-0.3	0.1
Reaction time trials completed	0.2	0.7	2.8	-0.5	-0.3	1.4	0.9	-1.7	0.2	0.6	0.6	-0.3
Reaction time trials AUC	0.2	0.8	3.1	-0.6	-0.3	1.5	0.9	-1.7	0.3	0.6	0.6	-0.4
Run reversals in cocaine runway, females	1.2	1.3	4.7	1.3	1.2	-1.8	-0.4	2.2	0.1	0.4	0.2	-0.8
Run reversals in cocaine runway, males	0.6	0.7	1.4	-1.0	-0.8	1.1	-0.3	-1.2	-0.2	-1.0	-0.7	0.6
Latency to leave start box in cocaine runway	0.2	0.3	0.8	0.4	0.2	-0.8	-0.9	0.7	0.4	-0.2	-0.0	-0.5
Latency to leave start box in cocaine runway, F	0.4	0.6	1.1	0.8	0.6	-0.8	-0.3	0.8	1.0	0.2	0.5	-1.1
Latency to leave start box in cocaine runway, M	1.1	1.1	2.1	-1.1	-1.1	0.5	-1.5	-0.6	-0.9	-1.3	-1.2	0.8
Std. dev. time between licks in bursts	0.2	0.3	1.0	-0.5	-0.4	1.0	-0.1	-0.9	0.0	0.2	0.1	-0.5
Total sessions with >9 infusions	1.8	2.3	4.0	-2.0	-1.8	1.8	-1.2	-1.6	-1.4	-1.4	-1.3	0.9
Short access day 1 total inactive lever presses	0.5	1.1	2.3	-1.5	-1.1	1.4	-1.2	-0.5	-0.6	-1.1	-0.9	0.0
Short access day 10 total inactive lever presses	0.1	0.4	1.8	0.5	0.3	-0.9	-0.5	1.3	-0.3	0.1	-0.1	-0.1
Short access day 1 total infusions	0.3	0.6	1.3	-1.1	-0.8	1.1	-0.2	-1.2	-0.2	-0.7	-0.5	0.3
Short access day 10 total infusions	0.3	0.5	2.4	-1.0	-0.5	1.6	0.0	-0.7	-0.0	0.1	0.1	-0.7
Short access total infusions	0.2	0.3	1.4	-0.8	-0.5	1.2	0.2	-0.6	0.1	-0.0	0.0	-0.3
Short access day 1 locomotion	1.0	1.6	3.4	-1.9	-1.4	1.6	-0.9	-1.1	-0.8	-1.5	-1.1	0.6
Short access day 10 total locomotion	0.1	0.5	1.5	-0.1	-0.4	-0.5	-1.2	0.8	-1.2	-0.2	-0.6	0.2
Short access total locomotion	0.1	0.2	0.6	-0.5	-0.6	0.5	-0.5	-0.3	-0.8	-0.1	-0.3	0.1
One hour access (0.3 mA shock)	1.5	1.8	5.8	-0.9	-0.9	0.1	-2.4	1.4	-1.9	-0.9	-1.4	-0.4
Compulsive drug intake	0.9	1.3	2.7	-1.2	-1.1	0.6	-1.6	-0.4	-1.3	-1.4	-1.4	0.4
One hour access (shock baseline)	0.2	0.4	2.0	-0.2	0.1	0.2	-0.7	1.4	-0.3	0.3	0.1	-1.1
Social response proportion	0.4	0.5	2.0	-0.8	-0.5	0.8	-1.4	0.3	-0.0	-0.7	-0.6	-0.7
Social responses	2.7	3.6	5.7	-2.3	-2.1	1.9	-2.4	-1.5	-1.6	-2.0	-1.9	0.8
Social time	1.5	2.4	4.4	-1.5	-1.9	0.8	-2.1	-1.3	-1.9	-1.3	-1.5	1.3
Soleus weight	0.1	0.2	1.0	-0.4	-0.3	1.0	0.1	-0.7	0.5	-0.1	-0.1	-0.5
Bone: stiffness	2.2	4.1	6.4	-2.5	-2.4	2.4	-2.0	-2.0	-1.4	-2.0	-1.9	1.0
Tibialis anterior weight	0.8	2.8	5.4	-0.1	0.5	2.2	2.3	-1.2	2.1	1.3	1.6	-2.1
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.4	0.1	-0.0	0.1	-0.3	0.6	0.3	0.3	0.2	-0.6
Time to tail flick, vehicle, after self-admin	0.2	0.5	1.1	-0.2	-0.2	-0.6	-0.9	0.9	-0.2	-1.1	-0.9	0.6
Time to tail flick, test, before self-admin	0.1	0.2	0.4	0.6	0.1	-0.6	0.2	-0.3	0.1	0.5	0.3	0.4
Time to tail flick, test, after self-admin	0.3	0.3	0.5	0.7	0.6	-0.7	0.5	0.4	0.6	0.3	0.5	-0.2
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	1.1	-0.3	-0.2	-0.3	-0.4	-0.0	0.0	-1.0	-0.7	0.8
Delta time to tail flick, test, before/after SA	0.0	0.0	0.1	-0.3	0.1	0.1	-0.2	0.3	0.0	-0.4	-0.1	-0.3
Tibia length	3.6	10.0	15.2	-3.9	-3.8	3.4	-2.9	-3.6	-2.9	-2.8	-2.8	2.1
Ambulatory time before self-admin	0.5	1.4	2.5	-1.1	-1.5	0.7	-1.1	-1.5	-1.6	-0.7	-1.0	1.2
Ambulatory time after self-admin	0.1	0.2	0.8	0.5	0.1	-0.4	0.3	-0.1	-0.1	0.9	0.5	0.0
Bone: tissue strength	0.2	0.3	0.5	0.7	0.3	-0.4	-0.0	0.4	0.5	0.7	0.5	-0.7
Total heroin consumption	0.1	0.1	0.3	0.2	0.2	0.1	0.3	0.0	0.2	0.5	0.5	-0.4
Bone: trabecular number	0.2	0.3	1.2	-0.1	-0.2	0.0	0.6	-0.9	-0.1	-0.4	-0.4	1.1
Bone: trabecular spacing	0.0	0.0	0.1	0.1	0.1	0.0	0.1	-0.1	0.1	0.2	0.2	-0.2
Bone: trabecular thickness	0.1	0.2	0.4	-0.5	-0.3	0.6	-0.1	-0.7	0.3	-0.4	-0.2	0.1
Bone: trabecular tissue density	0.9	1.7	2.9	1.2	1.4	-0.8	0.9	1.7	1.5	0.9	1.2	-1.7
Water consumed over 24 hours	0.3	0.5	1.0	-0.2	-0.6	-0.3	-1.0	-0.2	-0.9	-0.7	-1.0	0.8
Number of responses in last shaping day	0.2	0.3	1.0	-0.8	-0.3	1.0	-0.5	-0.0	0.1	-0.3	-0.2	-0.7