Hub : Genes

Myof

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 LHb isoform ratio XM_006231325.5 0.15 0.09 5.2e-03 0.04 0.07 0.03 0.03 3.3e-02 8.9e-03 5.5e-02 6.4e-02
2 PL gene expression Myof 0.21 0.07 0.0e+00 0.27 0.28 0.28 0.27 6.2e-29 2.9e-30 1.5e-30 5.9e-30
3 pVTA gene expression Myof 0.08 0.04 2.2e-05 0.03 0.05 0.05 0.05 1.1e-03 3.9e-05 5.5e-05 4.0e-05
4 Brain gene expression Myof 0.13 0.05 2.2e-16 0.17 0.16 0.16 0.17 2.9e-15 8.7e-15 1.8e-14 2.1e-15
5 Liver gene expression Myof 0.04 0.03 1.2e-03 0.01 0.01 0 0 4.9e-02 9.0e-03 1.7e-01 8.2e-02
6 BLA gene expression Myof 0.08 0.04 2.1e-04 0.06 0.07 0.06 0.06 6.7e-04 1.7e-04 4.3e-04 4.5e-04
7 Adipose mRNA stability Myof 0.08 0.03 1.5e-08 0.07 0.06 0.06 0.06 5.9e-08 1.8e-07 2.0e-07 4.4e-07
8 IL gene expression Myof 0.56 0.15 4.0e-09 0.27 0.29 0.26 0.28 3.9e-07 1.2e-07 6.1e-07 2.3e-07
9 NAcc gene expression Myof 0.06 0.03 6.8e-10 0.07 0.06 0.05 0.07 3.5e-11 1.6e-09 1.3e-08 2.0e-10
10 Brain mRNA stability Myof 0.06 0.04 1.1e-05 0.06 0.06 0.04 0.06 3.2e-06 3.9e-06 1.3e-04 6.3e-06
11 PL mRNA stability Myof 0.03 0.02 3.2e-03 0.02 0.02 0.02 0.02 1.0e-03 5.5e-03 2.1e-03 9.8e-04
12 Adipose gene expression Myof 0.28 0.09 0.0e+00 0.18 0.2 0.2 0.2 1.8e-19 1.7e-21 1.3e-21 1.1e-21
13 NAcc mRNA stability Myof 0.03 0.02 3.6e-04 0.01 0.01 0.01 0.01 4.5e-03 2.4e-03 3.7e-02 2.8e-02
14 IC gene expression Myof 0.11 0.06 2.6e-03 0 0.04 0.02 0.01 3.0e-01 6.8e-03 6.7e-02 1.3e-01
15 OFC gene expression Myof 0.28 0.11 4.2e-04 0.09 0.13 0.12 0.11 4.0e-03 5.1e-04 8.3e-04 1.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density4.37.411.33.23.43.12.82.82.82.72.82.82.32.52.42.22.52.2
Area under the delay curve0.30.41.0-0.90.1-0.5-0.6-1.0-0.6-0.4-0.3-0.3-0.5-0.1-0.9-0.90.30.8
BMI with tail0.20.82.10.80.80.80.80.60.50.71.20.81.41.50.50.70.60.9
BMI without tail0.00.10.3-0.2-0.4-0.3-0.5-0.1-0.2-0.4-0.3-0.4-0.2-0.0-0.0-0.1-0.4-0.5
Body weight0.10.41.10.80.81.10.60.30.90.3-0.10.30.60.50.60.50.6-0.5
Weight adjusted by age0.30.52.7-0.00.60.60.2-0.8-0.00.40.50.30.20.8-0.7-0.51.01.6
Bone surface3.56.310.03.23.12.62.43.02.62.42.52.42.52.52.42.11.81.5
Bone volume3.56.39.93.23.02.92.62.72.82.52.42.62.22.22.42.22.11.5
Breakpoint value in progressive ratio session0.20.20.9-0.9-0.4-0.5-0.2-0.8-0.2-0.3-0.6-0.2-0.5-0.4-0.6-0.50.40.2
Number of licking bursts0.71.12.5-1.4-0.4-1.6-1.3-1.2-1.2-1.1-0.7-1.1-0.8-0.3-1.1-1.1-0.50.2
Context. condit. distance diff. score1.72.13.31.11.81.61.80.81.61.31.31.41.41.31.41.71.80.9
Locomotion velocity, session 11.41.53.9-1.0-0.9-2.0-1.5-0.3-1.5-1.1-0.6-1.2-1.3-0.9-1.3-1.3-1.7-0.3
Locomotion distance, session 10.50.71.3-0.8-0.4-1.1-0.8-0.8-0.9-1.0-0.6-0.9-0.8-0.5-1.1-1.0-0.7-0.2
Locomotion velocity, session 20.80.93.60.51.0-0.70.41.90.50.71.10.81.11.41.31.0-0.10.7
Locomotion distance, session 20.10.10.8-0.4-0.0-0.9-0.10.1-0.2-0.30.1-0.20.30.40.10.2-0.1-0.0
Locomotion velocity, session 30.30.30.80.50.70.40.70.70.60.60.50.70.10.10.60.90.4-0.0
Locomotion distance, session 30.50.52.20.50.40.50.70.70.90.50.20.6-0.0-0.40.91.50.3-1.0
Stereotopy head waving bouts, day 30.30.30.90.71.00.40.30.70.30.50.90.60.20.60.10.10.20.9
Stereotopy head waving duration, day 30.50.62.70.61.10.60.30.30.40.50.90.50.61.10.2-0.20.71.6
Locomotion velocity, session 72.83.04.61.41.21.81.91.22.11.81.41.92.11.82.02.01.91.1
Locomotion distance, session 71.72.13.81.30.91.41.61.21.91.31.01.51.91.41.91.81.30.5
Stereotopy head waving bouts, day 70.20.21.00.11.0-0.20.10.5-0.10.40.70.4-0.30.2-0.20.00.20.8
Stereotopy head waving duration, day 70.20.31.30.71.10.30.20.80.10.60.80.5-0.00.30.10.10.10.6
Locomotion velocity, session 80.30.31.00.51.00.50.70.60.70.40.50.50.30.50.50.60.60.6
Locomotion distance, session 81.01.42.60.41.50.61.50.61.11.01.31.01.31.61.01.41.61.2
Degree of sensitization distance0.50.52.0-0.10.20.30.4-0.20.50.30.30.41.21.30.4-0.10.91.4
Degree of sensitization stereotypy0.10.10.4-0.30.6-0.5-0.30.2-0.5-0.1-0.0-0.1-0.6-0.3-0.5-0.3-0.30.0
Conditioned locomotion0.10.10.80.3-0.10.90.2-0.50.00.1-0.10.10.1-0.30.00.20.2-0.4
Cocaine response after cond. corrected0.20.20.5-0.4-0.1-0.6-0.7-0.2-0.5-0.5-0.5-0.50.20.2-0.2-0.4-0.6-0.6
Cocaine response after cond. not corrected0.10.10.3-0.50.1-0.4-0.5-0.3-0.2-0.3-0.5-0.20.20.3-0.1-0.2-0.1-0.3
Cocaine response before conditioning0.10.10.4-0.40.2-0.10.2-0.20.20.20.00.2-0.30.1-0.20.10.60.6
Saline control response2.12.87.0-2.3-1.5-1.2-1.1-2.6-1.5-1.6-1.6-1.6-2.0-1.6-2.2-1.80.10.1
Bone: connectivity density5.68.712.13.53.32.92.93.33.03.03.33.02.72.92.82.52.32.4
Bone: cortical apparent density0.30.40.9-0.8-0.4-0.9-0.7-0.6-0.7-0.7-0.3-0.7-0.7-0.2-0.6-1.0-0.40.8
Bone: cortical area0.71.12.71.41.21.61.41.01.50.90.40.90.50.11.11.21.1-0.3
Bone: cortical porosity1.61.73.60.81.00.81.20.91.21.21.41.11.81.91.21.01.41.7
Bone: cortical porosity1.61.73.11.01.10.91.21.31.41.31.31.21.71.71.51.21.21.2
Bone: cortical thickness1.01.63.4-1.2-1.0-0.7-0.9-1.5-0.9-1.4-1.7-1.4-1.8-1.8-1.3-1.0-0.6-1.4
Bone: cortical thickness1.61.83.6-1.6-1.1-1.4-1.2-1.6-1.2-1.4-1.4-1.4-1.9-1.5-1.5-1.4-0.6-0.5
Bone: cortical tissue density0.30.40.9-0.8-0.3-0.9-0.7-0.6-0.7-0.6-0.2-0.6-0.7-0.1-0.6-0.9-0.40.9
Condit. Reinf. active minus inactive responses0.20.20.7-0.4-0.3-0.9-0.30.2-0.2-0.2-0.4-0.0-0.2-0.40.20.3-0.6-0.7
Condit. Reinf. active-inactive response ratio0.30.31.1-0.1-0.4-0.8-0.50.5-0.4-0.3-0.3-0.0-0.3-0.50.10.1-1.0-0.9
Condit. Reinf. active responses0.10.20.5-0.5-0.6-0.4-0.2-0.4-0.1-0.3-0.7-0.2-0.2-0.4-0.10.1-0.1-0.7
Condit. Reinf. inactive responses0.10.10.8-0.4-0.50.40.1-0.90.0-0.3-0.4-0.30.0-0.1-0.4-0.30.60.1
Incentive salience index mean0.91.12.1-1.4-1.2-1.4-1.0-0.9-0.9-1.0-1.3-0.8-1.0-1.2-0.8-0.4-0.9-1.4
Condit. Reinf. lever presses2.63.75.5-2.3-2.3-1.9-1.8-2.3-1.9-2.0-2.1-1.8-1.8-1.9-1.9-1.6-1.4-1.5
Condit. Reinf. active minus inactive responses2.43.13.91.61.82.01.91.11.91.81.71.91.71.71.61.92.01.3
Condit. Reinf. active-inactive response ratio1.51.82.31.21.51.51.40.71.21.31.51.41.41.51.11.31.51.3
Condit. Reinf. active responses0.40.62.50.90.71.61.10.00.90.70.40.70.10.10.40.71.10.2
Condit. Reinf. inactive responses1.21.53.9-0.7-1.2-0.2-0.8-1.1-0.7-1.2-1.5-1.2-1.9-2.0-1.2-1.1-0.8-1.6
Condit. Reinf. lever presses0.30.41.5-0.5-0.1-0.4-0.5-0.6-0.6-0.6-0.5-0.6-1.2-1.0-0.7-0.7-0.3-0.3
Condit. Reinf. lever reinforcers received0.20.31.40.50.41.20.7-0.30.60.40.20.4-0.2-0.1-0.00.40.90.2
Conditioned reinforcement - actives0.30.62.50.91.20.30.51.60.80.60.60.80.10.20.80.70.2-0.0
Conditioned reinforcement - inactives1.62.35.31.52.00.81.32.31.71.51.51.61.31.51.71.61.00.9
Conditioned locomotion0.10.10.70.70.00.40.00.80.50.10.00.1-0.2-0.10.3-0.2-0.1-0.0
Patch foraging indifference point 0 sec0.81.53.3-0.6-1.0-1.1-1.3-0.3-1.0-1.2-1.3-1.0-1.7-1.8-0.9-0.9-1.6-1.6
Patch foraging indifference point AUC3.14.57.2-2.4-1.9-2.1-2.1-2.3-1.9-2.2-2.4-2.2-2.7-2.1-2.3-2.4-1.2-0.9
Delay disc. indifference point, 0s delay1.71.95.10.61.21.21.20.31.11.81.51.70.91.20.71.12.22.3
Delay disc. indifference point, 16s delay0.30.31.0-0.6-0.2-0.5-0.5-0.6-0.5-0.7-0.6-0.4-0.7-0.4-0.9-1.0-0.10.2
Delay disc. indifference point, 2s delay0.20.22.10.00.40.2-0.1-0.3-0.00.20.50.1-0.00.5-0.2-0.50.61.4
Delay disc. indifference point, 24s delay1.01.22.3-1.5-0.8-1.3-1.1-1.3-0.9-1.3-1.3-1.2-0.9-0.7-1.0-1.2-0.5-0.3
Delay disc. indifference point, 4s delay0.40.41.1-1.0-0.1-0.5-0.5-1.1-0.5-0.3-0.3-0.2-0.50.0-0.8-0.70.71.0
Delay disc. indifference point, 8s delay1.72.03.8-1.7-0.9-1.4-1.6-1.9-1.7-1.4-1.3-1.3-1.3-0.9-1.9-1.9-0.70.1
Indifference point function ln k3.15.57.42.72.22.32.52.62.32.42.42.52.72.32.62.71.40.8
Indifference point function log k3.15.57.42.72.22.32.52.62.32.42.42.52.72.32.62.71.40.8
Patch foraging total patch changes 0 sec0.81.53.3-0.5-0.9-1.0-1.3-0.3-1.0-1.1-1.3-0.9-1.7-1.8-0.9-1.0-1.6-1.6
Patch foraging total patch changes 12 sec4.76.19.8-2.4-2.3-2.5-2.7-2.2-2.5-2.5-2.5-2.4-3.1-2.8-2.6-2.8-2.1-1.3
Patch foraging total patch changes 18 sec1.01.53.5-1.3-1.1-1.3-1.4-1.1-1.3-1.1-1.0-1.1-1.9-1.3-1.4-1.6-0.8-0.2
Patch foraging total patch changes 24 sec0.81.32.8-1.0-0.8-1.0-1.2-0.9-0.8-0.9-1.5-0.9-1.7-1.7-0.8-1.0-0.9-1.3
Patch foraging total patch changes 6 sec4.36.611.6-2.2-1.9-2.8-2.8-1.5-2.4-2.6-2.8-2.6-3.4-3.1-2.2-2.5-2.7-2.3
Patch foraging time to switch 0 sec0.51.12.0-1.3-0.8-1.4-1.3-1.1-1.4-1.1-0.7-1.2-0.7-0.4-1.2-1.0-0.8-0.3
Patch foraging water rate 0 sec0.81.72.71.50.91.31.51.71.61.51.11.61.10.91.61.50.80.5
Patch foraging water rate 12 sec0.40.82.21.10.80.61.01.51.00.90.60.80.70.51.31.30.1-0.5
Patch foraging water rate 18 sec1.21.83.31.31.01.01.61.71.61.31.11.51.41.21.81.70.90.3
Patch foraging water rate 24 sec0.70.91.30.91.21.11.10.81.10.80.70.91.11.11.11.21.00.2
Patch foraging water rate 6 sec0.10.20.50.70.50.30.40.70.40.30.30.40.40.50.40.3-0.10.1
Seeking ratio, delayed vs. immediate footshock0.20.20.6-0.5-0.3-0.4-0.3-0.4-0.3-0.1-0.6-0.3-0.7-0.6-0.5-0.0-0.2-0.7
Distance traveled before self-admin0.60.81.70.51.00.10.81.20.81.21.01.20.60.71.11.30.60.7
Distance traveled after self-admin2.53.05.71.62.11.11.61.81.61.92.11.81.61.81.61.21.52.4
Extensor digitorum longus weight0.31.13.50.30.61.31.5-0.21.30.90.60.71.10.80.91.21.90.8
Bone: elastic displacement0.20.21.30.3-0.5-0.1-0.10.2-0.30.40.80.40.20.4-0.2-0.4-0.31.2
Bone: elastic work0.70.93.01.00.50.40.71.10.61.21.61.20.81.00.60.40.41.7
Bone: endosteal estimation5.211.515.74.03.83.63.43.83.93.43.03.43.53.13.73.12.71.8
Bone: endosteal perimeter5.010.715.33.93.93.63.43.63.63.43.13.33.22.93.33.02.61.8
Epididymis fat weight0.72.26.41.81.42.51.70.61.61.61.51.61.11.01.01.01.61.3
Delta time in closed arm before/after self-admin0.60.61.7-0.3-0.9-0.6-0.9-0.3-0.3-0.9-1.1-0.9-0.3-0.4-0.3-0.6-1.1-1.3
Delta time in open arm before/after self-admin1.51.54.00.51.30.41.21.00.81.41.51.41.11.40.90.91.32.0
Diff in mean of infusions in LGA sessions1.31.62.31.30.81.31.31.31.51.41.21.41.31.21.41.21.21.1
Delay discount exponential model param0.40.41.00.9-0.10.60.71.00.60.50.50.40.60.10.91.0-0.2-0.7
Extinction: sum of active levers before priming0.10.10.8-0.1-0.2-0.3-0.00.10.4-0.4-0.7-0.4-0.1-0.30.30.2-0.2-0.9
Active lever presses in extinction session 64.84.78.21.32.61.52.31.22.02.12.22.12.62.91.72.02.72.5
Bone: final force0.10.20.70.60.80.40.40.70.70.1-0.20.10.30.10.50.50.2-0.7
Bone: final moment0.20.30.70.80.80.50.30.80.70.1-0.20.10.40.00.60.4-0.0-0.8
Food consumed during 24 hour testing period0.30.31.6-0.1-0.2-0.8-0.60.5-0.2-0.6-0.6-0.5-0.2-0.50.10.0-1.0-1.3
Glucose0.10.10.50.40.10.30.20.50.40.2-0.10.20.1-0.20.50.5-0.2-0.7
Heart weight0.61.03.60.4-1.1-0.1-1.00.4-0.3-1.0-1.0-0.9-0.6-1.10.1-1.0-1.9-1.6
Delay discount hyperbolic model param0.30.30.80.8-0.10.50.70.90.60.40.30.30.50.10.80.9-0.2-0.8
Intermittent access intake day 1-15 change1.32.77.92.31.91.51.52.81.51.81.61.71.00.71.81.90.5-0.1
Intermittent access intake escalation1.94.09.12.62.41.92.03.01.92.22.12.11.31.02.12.31.00.3
Intermittent access intake escalation 24.55.111.62.62.51.72.23.42.02.62.52.41.71.52.52.71.20.7
Intermitt. access day 1 inactive lever presses0.10.20.80.4-0.20.20.20.50.30.60.70.60.50.70.40.20.30.9
Intermitt. access day 15 inactive lever presses0.71.53.21.80.81.71.11.41.51.11.11.31.11.01.20.60.81.0
Intermitt. access escalation Index0.10.20.50.30.10.70.40.0-0.00.70.50.70.50.30.30.50.20.3
Intermittent access day 1 total infusions0.61.01.81.10.71.01.01.01.31.01.01.00.91.10.90.81.11.2
Intermittent access day 15 total infusions2.43.67.32.51.82.12.02.72.11.91.72.01.41.02.02.11.20.2
Intermittent access terminal intake (last 3 days)2.83.67.62.51.82.01.92.82.12.01.92.01.51.32.02.01.20.7
Intermittent access total infusions1.51.83.11.81.01.71.51.71.71.31.31.41.11.01.31.31.10.7
Intermittent access day 1 locomotion0.40.50.90.90.60.80.60.70.90.50.60.50.90.90.70.50.60.5
Intermittent access day 15 total locomotion0.10.10.50.70.30.40.30.70.50.10.20.00.10.20.1-0.10.20.1
Intermittent access total locomotion0.80.91.51.10.91.01.01.01.20.71.00.70.91.20.70.61.11.1
Intermittent access standard deviation1.63.310.02.31.91.41.73.22.11.91.41.81.31.02.42.10.6-0.1
Left kidney weight0.10.41.9-0.20.1-0.0-0.5-0.3-0.1-0.9-1.2-0.8-0.3-0.4-0.2-0.5-0.5-1.4
Right kidney weight0.52.46.0-1.2-1.2-1.1-1.6-1.2-1.1-1.8-2.2-1.8-1.4-1.6-1.2-1.3-1.5-2.5
Cocaine induced anxiety1.31.93.11.01.11.51.20.61.11.61.51.61.81.71.01.31.61.5
Post-drug Anxiety0.10.11.00.3-0.51.0-0.2-0.6-0.20.1-0.10.10.2-0.2-0.3-0.30.1-0.1
Baseline Anxiety1.82.13.7-0.6-1.4-0.6-1.4-1.0-1.0-1.7-1.8-1.6-1.5-1.9-1.1-1.6-1.7-1.9
Tail length0.10.20.8-0.00.20.4-0.0-0.10.6-0.0-0.9-0.1-0.5-0.60.30.20.4-0.9
Length with tail0.10.31.30.10.70.70.2-0.20.7-0.2-1.1-0.3-0.4-0.50.2-0.10.5-1.0
Length without tail0.41.22.70.91.61.71.40.41.50.70.20.71.31.10.90.61.50.4
Times rat made contact with spout0.40.52.30.10.50.30.60.20.60.70.80.60.61.00.50.41.01.5
Lifetime Intake1.11.42.61.60.91.51.31.41.61.11.21.20.80.91.01.01.10.8
Liver weight, left0.20.31.5-0.3-0.20.1-0.3-0.5-0.2-0.8-1.0-0.7-0.5-0.5-0.4-0.5-0.4-1.2
Liver weight, right0.50.81.61.11.21.20.80.91.10.70.50.80.90.91.00.50.80.3
Locomotor activity0.20.31.10.50.2-0.30.31.00.30.80.80.90.20.40.50.7-0.10.2
Locomotor testing distance0.20.31.50.40.2-0.60.11.20.10.70.70.8-0.10.10.40.5-0.40.1
Locomotor testing rearing0.71.42.60.90.90.71.41.31.21.61.41.60.70.81.11.51.31.0
Locomotion in novel chamber3.95.07.32.22.22.02.42.12.12.12.72.22.62.62.02.32.11.9
Locomotion in novel chamber post-restriction0.10.20.5-0.60.2-0.20.1-0.7-0.0-0.6-0.5-0.7-0.2-0.1-0.4-0.20.5-0.2
Fecal boli incidents, locomotor time 11.11.73.10.81.20.91.30.71.41.21.31.41.21.81.01.21.61.6
Change in fecal boli incidents, locomotor task1.61.52.3-1.2-1.2-1.2-1.2-1.1-1.3-1.0-1.3-1.2-1.3-1.5-1.4-1.0-1.2-1.3
Time >=10cm from walls, locomotor time 10.30.42.7-0.40.3-0.10.30.20.4-0.1-0.9-0.30.0-0.60.60.80.0-1.6
Bouts of movement, locomotor time 10.10.10.5-0.10.50.20.2-0.5-0.30.10.10.3-0.3-0.1-0.7-0.20.50.2
Total resting periods, locomotor time 10.10.10.5-0.40.50.00.1-0.6-0.30.0-0.00.3-0.4-0.0-0.7-0.30.50.3
Rest time, locomotor task time 10.40.52.1-0.01.20.20.4-0.20.00.80.71.20.10.7-0.2-0.20.91.4
Distance moved, locomotor task time 10.81.23.2-0.7-1.6-0.9-0.9-0.4-0.3-1.1-1.4-1.4-0.8-1.5-0.2-0.2-1.1-1.8
Vertical activity count, locomotor time 10.41.04.5-0.4-0.6-0.8-1.0-0.0-0.7-1.0-1.3-1.3-0.6-1.1-0.2-0.3-1.5-2.1
Time >=10cm from walls, locomotor time 20.10.20.7-0.40.6-0.10.40.10.30.6-0.20.50.2-0.30.50.80.5-0.3
Bouts of movement, locomotor time 20.81.33.5-1.7-0.8-1.9-1.2-1.1-1.4-0.9-0.6-0.9-1.6-0.7-1.4-1.0-0.50.3
Total resting periods, locomotor time 20.71.33.5-1.7-0.7-1.9-1.1-1.1-1.4-0.8-0.6-0.9-1.6-0.7-1.4-0.9-0.40.3
Rest time, locomotor task time 20.30.41.2-1.00.8-0.5-0.2-1.1-0.6-0.3-0.3-0.2-0.50.2-0.9-0.50.60.4
Distance moved, locomotor task time 20.30.30.90.6-0.60.50.40.70.80.5-0.00.20.5-0.31.00.9-0.1-0.6
Vertical activity count, locomotor time 20.20.21.00.5-0.1-0.1-0.21.00.30.3-0.10.30.5-0.10.70.4-0.8-0.6
Light reinforcement 10.10.30.7-0.3-0.0-0.2-0.4-0.7-0.5-0.7-0.1-0.6-0.7-0.4-0.8-0.80.10.5
Light reinforcement 20.71.02.5-1.1-0.6-1.0-1.0-1.3-1.3-1.0-0.4-1.1-0.6-0.1-1.3-1.6-0.60.9
Bone: marrow area5.512.016.34.03.93.73.53.83.93.53.13.53.53.23.73.12.82.0
Bone: maximum diameter6.512.117.14.04.14.13.93.43.83.63.23.53.22.93.33.33.21.9
Bone: maximum force1.11.94.11.82.01.51.51.71.71.11.11.11.11.01.41.31.10.4
Bone: maximum moment1.11.94.02.01.91.61.41.91.71.11.11.11.11.01.51.10.90.3
Mean time between licks in bursts0.41.02.7-0.3-1.1-0.6-0.9-0.1-0.8-0.7-0.9-0.6-1.2-1.5-0.6-0.6-1.7-1.5
Mean num. licks in bursts1.42.33.61.60.81.91.81.51.81.71.41.71.41.11.61.51.30.9
Cd content in liver1.21.33.0-0.6-1.3-1.2-1.3-0.2-1.2-1.1-0.8-1.1-1.1-1.4-0.9-0.9-1.7-1.3
Co content in liver2.22.65.5-0.6-2.0-0.9-1.6-0.7-1.4-1.5-1.5-1.6-1.9-2.3-1.2-1.4-2.2-1.8
Cu content in liver3.74.49.1-2.0-1.5-2.4-2.5-1.7-2.4-2.2-2.0-2.1-2.0-1.7-2.3-3.0-2.0-0.5
Fe content in liver2.32.73.7-1.8-1.9-1.9-1.9-1.5-1.9-1.7-1.6-1.6-1.4-1.3-1.7-1.7-1.6-1.2
K content in liver0.30.31.4-1.2-0.4-0.9-0.1-0.8-0.4-0.2-0.2-0.00.20.5-0.4-0.20.50.6
Mg content in liver0.30.31.2-1.0-0.7-1.1-0.5-0.6-0.7-0.6-0.4-0.30.10.2-0.4-0.5-0.3-0.0
Mn content in liver1.21.32.6-1.6-0.7-1.5-1.0-1.4-1.5-1.3-0.5-1.4-0.50.1-1.3-1.6-0.40.7
Na content in liver1.11.23.3-1.8-1.3-1.5-1.0-1.5-1.2-1.1-1.0-0.9-0.6-0.4-1.2-0.9-0.4-0.1
Rb content in liver0.10.20.50.40.40.40.30.50.50.30.00.50.70.40.70.30.1-0.2
Se content in liver18.421.835.1-5.3-4.6-5.9-5.4-4.2-5.4-4.9-4.2-4.9-4.1-3.5-4.7-4.9-4.6-2.4
Sr content in liver0.20.20.9-0.1-0.3-0.8-0.50.5-0.5-0.4-0.1-0.4-0.5-0.3-0.2-0.4-0.9-0.3
Zn content in liver2.32.66.6-2.2-1.8-2.6-1.9-1.5-1.8-1.6-1.5-1.3-1.0-0.9-1.3-1.5-1.5-0.6
Bone: minimum diameter6.511.917.54.23.64.13.83.94.13.52.93.53.22.53.83.72.81.0
Time in familiar zone, hab. session 10.40.41.01.01.00.60.20.70.50.60.70.40.70.80.40.10.30.8
Time in novel zone, hab. session 10.40.41.1-1.0-0.9-0.8-0.4-0.7-0.5-0.6-0.6-0.5-0.7-0.6-0.5-0.3-0.1-0.2
Total zone transitions, hab. session 10.00.00.1-0.10.4-0.20.20.0-0.0-0.10.20.10.10.3-0.2-0.10.20.3
Total locomotion distance, hab. session 10.91.32.1-1.4-0.9-1.5-1.1-1.3-1.3-1.2-0.9-1.0-1.2-0.9-1.4-1.1-0.7-0.4
Locomotion velocity, hab. session 12.02.84.2-2.1-1.5-2.0-1.6-2.0-1.8-1.8-1.5-1.6-1.8-1.4-2.0-1.6-1.0-0.9
Time in familiar zone, hab. session 20.20.20.80.1-0.4-0.1-0.5-0.1-0.4-0.3-0.3-0.4-0.9-0.9-0.5-0.6-0.8-0.3
Time in novel zone, hab. session 20.00.00.1-0.20.0-0.10.00.10.1-0.0-0.00.00.30.30.20.10.20.0
Total zone transitions, hab. session 20.70.91.3-0.8-0.7-1.0-0.8-0.7-1.0-1.1-0.9-1.1-1.0-1.0-1.1-1.0-1.0-0.9
Total locomotion distance, hab. session 21.21.62.1-1.1-1.1-1.2-1.2-1.2-1.2-1.4-1.2-1.4-1.4-1.4-1.4-1.2-1.2-1.1
Locomotion velocity, hab. session 21.31.72.6-1.3-1.2-1.4-1.2-1.4-1.3-1.5-1.2-1.5-1.4-1.2-1.6-1.3-1.0-0.9
Novel to familiar place preference ratio5.15.510.11.63.21.42.12.02.12.42.42.42.63.02.42.12.42.6
Novelty place preference5.45.810.41.73.21.52.12.12.22.42.52.42.63.12.52.12.52.7
Time in novel zone, NPP test5.55.810.11.73.21.52.22.12.22.52.52.52.63.12.52.22.42.6
Total zone transitions, NPP test1.01.42.1-1.4-1.3-1.3-1.1-1.3-1.1-1.4-1.4-1.3-0.9-1.1-1.1-1.0-1.0-1.2
Total locomotion distance, NPP test2.33.14.3-2.0-1.6-2.1-1.8-1.9-1.8-1.9-1.8-1.9-1.8-1.6-1.9-1.6-1.4-1.2
Locomotion velocity, NPP test2.23.14.6-2.1-1.7-2.1-1.7-2.0-1.8-1.9-1.8-1.9-1.8-1.6-1.8-1.6-1.3-1.2
Intraocular pressure0.20.20.6-0.0-0.1-0.0-0.6-0.5-0.3-0.7-0.3-0.7-0.6-0.5-0.6-0.8-0.20.1
Delta distance traveled before/after self-admin1.61.73.01.51.41.71.21.01.41.21.31.01.41.41.10.51.41.7
Delta ambulatory time before/after self-admin2.12.64.51.81.62.11.71.21.71.51.61.31.71.71.40.91.71.9
Parametrial fat weight0.71.62.6-1.5-1.5-1.1-1.1-1.4-1.0-1.3-1.6-1.2-1.4-1.5-1.2-0.9-0.9-1.3
Pavlov. Cond. lever latency0.10.10.80.90.30.60.00.60.00.20.4-0.1-0.20.00.0-0.4-0.30.3
Pavlov. Cond. magazine entry latency1.11.44.3-1.0-1.1-1.7-1.3-0.2-0.9-1.1-1.5-1.0-0.7-1.1-0.4-0.3-1.7-2.1
Pavlov. Cond. change in total contacts0.40.42.3-0.2-0.4-0.9-0.60.6-0.2-0.5-0.5-0.10.0-0.40.50.5-1.1-1.5
Pavlov. Cond. index score0.60.72.0-1.2-0.7-1.4-0.8-0.5-0.6-0.9-1.1-0.6-0.4-0.7-0.40.0-0.7-1.4
Pavlov. Cond. latency score0.50.61.6-1.2-0.6-1.3-0.6-0.7-0.5-0.8-1.0-0.5-0.3-0.6-0.40.1-0.4-1.2
Pavlov. Cond. lever contacts0.60.71.7-1.3-0.8-1.1-0.7-1.0-0.7-0.9-1.1-0.6-0.4-0.6-0.6-0.2-0.4-1.0
Pavlov. Cond. magazine entry number0.40.52.80.20.51.00.7-0.40.30.50.80.50.00.5-0.2-0.21.31.7
Pavlov. Cond. intertrial magazine entries0.10.10.5-0.3-0.20.40.1-0.7-0.1-0.2-0.1-0.0-0.3-0.3-0.3-0.10.50.0
Pavlov. Cond. lever-magazine prob. diff.0.60.82.2-1.2-0.8-1.5-0.8-0.5-0.7-0.8-1.1-0.6-0.4-0.7-0.30.0-0.8-1.4
Pavlov. Cond. response bias0.60.83.0-0.5-0.7-1.4-0.90.3-0.6-0.8-1.0-0.5-0.2-0.70.00.0-1.5-1.7
Pavlov. Cond. lever latency1.41.92.71.01.01.11.60.91.21.61.61.61.61.61.11.61.51.4
Pavlov. Cond. magazine entry latency0.50.62.0-0.5-0.8-0.9-1.00.0-0.5-0.7-0.9-0.7-0.3-0.70.1-0.1-1.2-1.4
Pavlov. Cond. change in total contacts0.61.01.8-1.0-1.0-0.9-1.1-1.0-0.8-1.0-1.4-1.0-1.1-1.3-0.9-0.9-0.8-1.0
Pavlov. Cond. index score1.01.32.4-0.9-0.8-1.0-1.4-0.7-0.9-1.2-1.5-1.3-1.2-1.4-0.6-0.9-1.2-1.4
Pavlov. Cond. latency score0.70.91.9-0.7-0.6-0.8-1.2-0.5-0.7-1.0-1.3-1.1-0.9-1.1-0.4-0.7-1.0-1.4
Pavlov. Cond. lever contacts1.72.33.4-1.1-1.2-1.1-1.7-1.2-1.3-1.7-1.8-1.7-1.8-1.8-1.3-1.8-1.5-1.4
Pavlov. Cond. magazine entry number2.32.84.41.62.01.81.91.11.41.72.11.61.41.81.11.21.82.1
Pavlov. Cond. intertrial magazine entries1.32.03.51.11.31.51.70.71.41.51.51.51.31.51.11.51.91.5
Pavlov. Cond. lever-magazine prob. diff.0.81.02.0-0.9-0.7-1.0-1.3-0.6-0.8-1.1-1.4-1.1-1.0-1.2-0.5-0.8-1.1-1.3
Pavlov. Cond. response bias1.72.33.5-1.2-1.4-1.4-1.8-1.0-1.3-1.6-1.9-1.6-1.7-1.8-1.0-1.5-1.7-1.6
Time in closed arm before self-admin1.01.32.20.71.50.51.20.90.91.31.51.21.01.11.01.21.21.4
Time in closed arm after self-admin0.10.10.6-0.6-0.3-0.5-0.2-0.8-0.2-0.3-0.3-0.4-0.3-0.2-0.4-0.20.10.1
Time in open arm before self-admin0.20.20.90.1-1.00.2-0.4-0.4-0.4-0.5-0.3-0.4-0.3-0.3-0.5-0.6-0.6-0.5
Time in open arm after self-admin0.10.10.40.20.5-0.10.10.5-0.00.30.50.40.10.4-0.0-0.10.20.7
Bone: periosteal estimation3.67.611.23.43.33.33.03.03.32.72.32.72.52.12.92.52.41.2
Bone: periosteal perimeter3.45.98.92.92.83.02.82.42.82.52.12.52.11.82.32.42.31.1
Bone: post-yield work1.72.45.42.02.31.71.61.91.91.11.21.21.31.21.81.61.20.3
Progressive ratio test 1 active lever presses0.40.50.91.00.60.90.80.80.90.50.80.60.30.60.30.20.70.7
Progressive ratio test 1 breakpoint0.20.30.50.70.40.70.60.60.70.30.60.40.10.30.10.10.60.6
Progressive ratio test 1 inactive lever presses1.21.82.61.61.11.31.41.61.61.31.51.41.11.31.31.01.21.3
Progressive ratio test 2 active lever presses3.13.75.62.42.22.01.92.42.22.02.02.01.51.61.61.51.71.4
Progressive ratio test 2 breakpoint3.43.86.02.42.22.12.02.42.22.12.02.11.41.61.71.61.71.4
Progressive ratio test 2 inactive lever presses1.42.23.41.81.41.41.51.81.61.61.81.71.11.31.21.11.31.6
Incentive Sensitization - Responses3.34.78.02.52.51.92.02.82.32.42.22.31.91.92.12.01.71.4
Incentive Sensitization - Breakpoint3.44.47.72.52.51.91.92.82.32.32.12.21.81.82.12.01.61.2
Sum of active levers in priming session hrs 5-60.40.31.2-0.2-0.8-0.9-0.90.1-0.6-0.4-0.4-0.4-0.4-0.4-0.3-0.6-1.1-0.4
Progressive ratio0.40.62.4-0.7-1.5-0.0-0.5-1.3-0.6-0.6-0.8-0.7-0.5-0.9-0.9-0.4-0.2-1.0
Food seeking constrained by brief footshock0.30.42.60.10.1-0.3-0.00.60.2-0.2-0.5-0.3-0.6-0.90.20.7-0.2-1.6
Seeking ratio, punishment vs. effort0.20.21.20.10.7-0.8-0.21.10.3-0.1-0.2-0.1-0.4-0.30.50.2-0.4-0.4
Retroperitoneal fat weight0.10.31.1-0.1-0.30.6-0.2-1.0-0.1-0.5-0.6-0.5-0.6-0.4-0.4-0.8-0.1-0.1
Reaction time number correct2.14.06.51.72.12.02.21.41.62.12.12.12.52.61.61.82.11.7
Reaction time mean minus median0.30.83.21.20.30.2-0.11.80.50.30.10.30.5-0.11.00.9-1.2-1.6
Reaction time mean minus median AUC0.20.62.41.00.10.1-0.31.40.10.30.00.20.50.00.80.6-1.4-1.6
Reaction time num false alarms0.20.31.0-0.6-0.40.1-0.2-1.0-0.0-0.6-0.8-0.4-0.8-0.7-0.4-0.30.4-0.5
Reaction time num false alarms AUC0.20.30.9-0.6-0.5-0.1-0.3-0.8-0.1-0.6-1.0-0.4-0.8-0.7-0.3-0.20.1-0.8
Reaction time trials correct on left2.14.06.51.72.12.02.21.41.62.12.12.12.52.61.61.82.11.7
Reaction time trials on left2.03.86.21.72.02.02.21.31.62.12.12.12.42.51.61.82.01.6
Reaction time mean1.11.84.6-0.6-1.6-1.4-1.50.1-0.8-1.3-1.4-1.1-1.2-1.7-0.5-0.6-2.2-2.1
Reaction time mean AUC1.52.45.6-0.8-1.8-1.7-1.8-0.2-1.1-1.6-1.6-1.5-1.4-1.9-0.7-0.9-2.4-2.2
Median of all reaction times1.41.93.8-0.9-1.8-1.6-1.6-0.4-0.9-1.4-1.4-1.3-1.4-1.8-0.7-0.9-2.0-1.7
Reaction time omissions0.40.62.30.8-0.20.40.21.00.50.50.10.50.80.01.11.2-0.6-1.5
Reaction time false alarm rate1.41.93.5-1.3-1.3-1.0-1.3-1.4-0.8-1.5-1.8-1.4-1.9-1.8-1.1-1.1-0.8-1.4
Reaction time premature initiation rate0.81.13.3-0.9-0.6-0.7-0.9-0.8-0.7-1.1-1.6-1.1-1.4-1.2-0.7-0.6-0.9-1.8
Reaction time premature initiations0.10.21.00.10.50.50.4-0.10.20.0-0.40.1-0.10.00.20.50.3-1.0
Std. dev. reaction times0.71.26.80.6-0.7-0.6-1.01.2-0.2-0.5-0.9-0.5-0.4-1.20.40.2-2.2-2.6
Reaction time trials completed2.03.86.21.72.02.02.21.31.62.12.12.12.42.51.61.82.01.6
Reaction time trials AUC1.83.56.01.51.91.92.11.21.52.02.02.02.42.41.51.72.01.6
Run reversals in cocaine runway, females0.20.20.6-0.3-0.1-0.8-0.6-0.1-0.4-0.5-0.1-0.6-0.40.0-0.4-0.7-0.40.4
Run reversals in cocaine runway, males3.33.44.6-1.9-1.8-1.6-1.7-1.7-1.8-2.1-2.0-2.1-2.1-2.1-1.7-1.6-1.4-1.6
Latency to leave start box in cocaine runway1.71.93.21.80.61.81.61.31.51.51.61.41.30.91.41.71.10.5
Latency to leave start box in cocaine runway, F2.63.04.41.91.01.92.11.61.92.02.01.91.51.21.72.11.51.1
Latency to leave start box in cocaine runway, M0.10.10.40.60.00.50.10.20.20.20.20.20.30.20.20.3-0.1-0.4
Std. dev. time between licks in bursts2.53.34.3-1.4-1.8-1.4-2.0-1.7-1.9-2.1-1.8-2.0-1.9-2.0-1.8-2.1-2.0-1.4
Total sessions with >9 infusions0.20.20.9-0.2-0.2-0.1-0.4-0.4-0.1-0.4-0.2-0.4-0.7-0.3-0.6-0.90.00.6
Short access day 1 total inactive lever presses2.83.78.42.01.61.91.91.41.81.72.51.81.82.31.31.12.02.9
Short access day 10 total inactive lever presses0.00.10.3-0.3-0.00.10.0-0.2-0.00.50.10.40.10.10.10.30.40.4
Short access day 1 total infusions0.10.20.9-0.2-0.1-0.1-0.4-0.5-0.2-0.5-0.1-0.3-0.5-0.1-0.7-0.90.00.7
Short access day 10 total infusions0.40.61.4-0.4-1.2-0.5-0.7-0.5-0.4-0.8-0.6-0.7-1.1-1.0-0.8-1.0-0.6-0.2
Short access total infusions0.30.41.10.70.50.70.50.50.80.40.70.50.10.50.30.00.71.1
Short access day 1 locomotion0.30.43.20.10.20.30.2-0.20.30.20.70.30.30.7-0.2-0.50.81.8
Short access day 10 total locomotion0.10.20.7-0.5-0.1-0.8-0.5-0.3-0.3-0.5-0.2-0.50.10.5-0.3-0.3-0.30.2
Short access total locomotion0.10.21.3-0.2-0.3-0.4-0.3-0.2-0.1-0.20.2-0.2-0.10.4-0.3-0.80.01.1
One hour access (0.3 mA shock)5.56.410.73.13.12.62.53.32.82.62.42.62.22.22.52.31.91.2
Compulsive drug intake1.11.32.21.01.51.41.10.91.11.41.01.41.00.81.41.31.00.7
One hour access (shock baseline)0.40.61.71.20.60.80.71.31.10.60.50.60.60.50.60.60.5-0.0
Social response proportion2.93.34.71.81.61.71.91.71.71.92.22.02.22.01.61.41.52.0
Social responses0.70.91.91.40.91.21.01.11.00.61.10.90.60.70.70.30.71.0
Social time0.60.81.7-1.1-1.3-0.8-0.7-1.0-0.8-1.1-0.9-0.9-0.7-0.9-0.8-0.9-0.5-0.4
Soleus weight1.44.16.52.52.12.42.02.02.21.81.81.82.42.22.11.61.51.1
Bone: stiffness1.22.03.61.41.81.71.81.11.91.20.91.21.10.91.51.61.80.5
Tibialis anterior weight0.82.77.50.61.41.72.00.11.81.71.21.61.91.81.31.82.71.6
Time to tail flick, vehicle, before self-admin0.40.42.4-0.50.0-0.4-0.5-0.7-0.6-0.30.3-0.3-0.20.5-0.7-1.10.21.5
Time to tail flick, vehicle, after self-admin0.30.41.9-0.30.40.30.5-0.40.70.50.10.60.50.60.40.71.40.5
Time to tail flick, test, before self-admin1.11.12.11.11.40.81.01.11.40.80.80.91.11.11.21.00.90.7
Time to tail flick, test, after self-admin0.30.32.5-0.30.10.00.0-0.4-0.00.50.40.40.20.7-0.0-0.30.71.6
Delta time to tail flick, vehicle, before/after SA1.00.92.90.20.60.91.20.11.30.90.20.90.90.61.01.61.7-0.1
Delta time to tail flick, test, before/after SA0.20.20.6-0.6-0.4-0.3-0.4-0.8-0.7-0.0-0.0-0.2-0.5-0.1-0.6-0.60.10.7
Tibia length0.10.41.1-0.3-0.5-0.4-0.7-0.1-0.4-0.7-0.9-0.7-0.4-0.7-0.4-0.6-0.8-1.0
Ambulatory time before self-admin0.40.61.20.40.7-0.10.71.10.51.11.01.10.40.50.91.10.40.6
Ambulatory time after self-admin5.05.98.82.12.81.72.42.42.32.72.92.52.32.52.32.02.23.0
Bone: tissue strength0.10.10.30.6-0.10.40.00.60.30.1-0.10.10.50.20.5-0.1-0.5-0.5
Total heroin consumption0.00.00.1-0.1-0.1-0.00.2-0.20.3-0.1-0.2-0.10.10.1-0.1-0.10.30.1
Bone: trabecular number3.25.38.73.02.82.52.22.82.42.32.42.41.92.02.21.91.71.6
Bone: trabecular spacing1.82.43.7-1.7-1.9-1.5-1.6-1.5-1.4-1.4-1.8-1.5-1.6-1.8-1.2-1.0-1.3-1.6
Bone: trabecular thickness2.63.35.52.32.12.12.02.12.01.91.82.01.41.31.71.71.40.9
Bone: trabecular tissue density0.81.11.81.01.21.31.30.71.11.11.11.00.80.91.00.91.31.2
Water consumed over 24 hours0.91.32.30.41.30.31.00.81.11.21.21.21.01.41.11.21.41.5
Number of responses in last shaping day0.20.21.00.5-0.10.6-0.3-0.0-0.4-0.10.2-0.1-0.2-0.1-0.6-1.0-0.30.5