Hub : Genes

Myof

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 LHb isoform ratio XM_006231325.5 0.15 0.09 5.2e-03 0.04 0.07 0.03 0.03 3.3e-02 8.9e-03 5.4e-02 6.4e-02
2 PL gene expression Myof 0.21 0.07 0.0e+00 0.27 0.28 0.28 0.27 6.2e-29 2.9e-30 1.5e-30 5.6e-30
3 pVTA gene expression Myof 0.08 0.04 2.2e-05 0.03 0.05 0.05 0.05 1.1e-03 3.9e-05 5.5e-05 4.0e-05
4 Brain gene expression Myof 0.13 0.05 2.2e-16 0.17 0.16 0.16 0.17 2.9e-15 8.7e-15 1.8e-14 2.1e-15
5 Liver gene expression Myof 0.04 0.03 1.2e-03 0.01 0.01 0 0 4.9e-02 9.0e-03 1.7e-01 7.8e-02
6 BLA gene expression Myof 0.08 0.04 2.1e-04 0.06 0.07 0.06 0.06 6.7e-04 1.7e-04 4.3e-04 3.9e-04
7 Adipose mRNA stability Myof 0.08 0.03 1.5e-08 0.07 0.06 0.06 0.06 5.9e-08 1.8e-07 2.0e-07 4.9e-07
8 IL gene expression Myof 0.56 0.15 4.0e-09 0.27 0.29 0.26 0.28 3.9e-07 1.2e-07 6.0e-07 2.1e-07
9 NAcc gene expression Myof 0.06 0.03 6.8e-10 0.07 0.06 0.05 0.07 3.5e-11 1.6e-09 1.3e-08 1.9e-10
10 Brain mRNA stability Myof 0.06 0.04 1.1e-05 0.06 0.06 0.04 0.06 3.2e-06 3.9e-06 1.4e-04 6.4e-06
11 PL mRNA stability Myof 0.03 0.02 3.2e-03 0.02 0.02 0.02 0.02 1.0e-03 5.5e-03 2.1e-03 1.2e-03
12 Adipose gene expression Myof 0.28 0.09 0.0e+00 0.18 0.2 0.2 0.2 1.8e-19 1.7e-21 1.3e-21 1.1e-21
13 NAcc mRNA stability Myof 0.03 0.02 3.6e-04 0.01 0.01 0.01 0.01 4.5e-03 2.4e-03 3.7e-02 2.8e-02
14 IC gene expression Myof 0.11 0.06 2.6e-03 0 0.04 0.02 0.01 3.0e-01 6.8e-03 6.8e-02 1.2e-01
15 OFC gene expression Myof 0.28 0.11 4.2e-04 0.09 0.13 0.12 0.1 4.0e-03 5.1e-04 8.3e-04 2.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density4.07.311.33.2-3.43.12.82.82.8-2.72.8-2.8-2.3-2.42.42.22.52.2
Area under the delay curve0.30.41.0-0.9-0.1-0.5-0.6-1.0-0.60.4-0.30.30.50.5-0.9-0.90.30.8
BMI with tail0.20.81.90.8-0.80.80.80.60.5-0.71.2-0.8-1.4-1.40.50.70.60.9
BMI without tail0.00.10.3-0.20.4-0.3-0.5-0.1-0.20.4-0.30.40.20.1-0.0-0.1-0.4-0.5
Body weight0.10.41.10.8-0.81.10.60.30.9-0.3-0.1-0.3-0.6-0.70.60.50.6-0.5
Weight adjusted by age0.10.42.7-0.0-0.60.60.2-0.8-0.0-0.40.5-0.3-0.2-0.2-0.7-0.51.01.6
Bone surface3.26.310.03.2-3.12.62.43.02.6-2.42.5-2.4-2.5-2.62.42.11.81.5
Bone volume3.26.49.93.2-3.02.92.62.72.8-2.52.4-2.6-2.2-2.32.42.22.11.5
Breakpoint value in progressive ratio session0.10.20.9-0.90.4-0.5-0.2-0.8-0.20.3-0.60.20.50.5-0.6-0.50.40.2
Number of licking bursts0.41.12.5-1.40.4-1.6-1.3-1.2-1.21.1-0.71.10.80.7-1.1-1.1-0.50.2
Context. condit. distance diff. score1.72.13.31.1-1.81.61.80.81.6-1.31.3-1.4-1.4-1.41.41.71.80.9
Locomotion velocity, session 11.41.53.9-1.00.9-2.0-1.5-0.3-1.51.1-0.61.21.31.3-1.3-1.3-1.7-0.3
Locomotion distance, session 10.50.71.3-0.80.4-1.1-0.8-0.8-0.91.0-0.60.90.80.8-1.1-1.0-0.7-0.2
Locomotion velocity, session 20.70.93.60.5-1.0-0.70.41.90.5-0.71.1-0.8-1.1-1.11.31.0-0.10.7
Locomotion distance, session 20.10.10.8-0.40.0-0.9-0.10.1-0.20.30.10.2-0.3-0.30.10.2-0.1-0.0
Locomotion velocity, session 30.30.30.80.5-0.70.40.70.70.6-0.60.5-0.7-0.1-0.10.60.90.4-0.0
Locomotion distance, session 30.40.52.20.5-0.40.50.70.70.9-0.50.2-0.60.00.00.91.50.3-1.0
Stereotopy head waving bouts, day 30.30.30.90.7-1.00.40.30.70.3-0.50.9-0.6-0.2-0.20.10.10.20.9
Stereotopy head waving duration, day 30.40.52.70.6-1.10.60.30.30.4-0.50.9-0.5-0.6-0.60.2-0.20.71.6
Locomotion velocity, session 72.93.14.61.4-1.21.82.01.22.1-1.81.4-1.9-2.1-2.12.02.01.91.1
Locomotion distance, session 71.72.23.81.3-0.91.41.61.21.9-1.31.0-1.5-1.9-1.91.91.81.30.5
Stereotopy head waving bouts, day 70.20.21.00.1-1.0-0.20.10.5-0.1-0.40.7-0.40.30.3-0.20.00.20.8
Stereotopy head waving duration, day 70.20.31.30.7-1.10.30.20.80.1-0.60.8-0.50.00.00.10.10.10.6
Locomotion velocity, session 80.30.31.00.5-1.00.50.70.60.7-0.40.5-0.5-0.3-0.30.50.60.60.6
Locomotion distance, session 80.91.42.60.4-1.50.61.50.61.1-1.01.3-1.0-1.3-1.31.01.41.61.2
Degree of sensitization distance0.40.52.0-0.1-0.20.30.4-0.20.5-0.30.3-0.4-1.2-1.20.4-0.10.91.4
Degree of sensitization stereotypy0.10.20.4-0.3-0.6-0.5-0.30.2-0.50.1-0.00.10.60.6-0.5-0.3-0.30.0
Conditioned locomotion0.10.10.80.30.10.90.2-0.50.0-0.1-0.1-0.1-0.1-0.00.00.20.2-0.4
Cocaine response after cond. corrected0.10.20.5-0.40.1-0.6-0.7-0.2-0.50.5-0.50.5-0.2-0.3-0.2-0.4-0.6-0.6
Cocaine response after cond. not corrected0.10.10.3-0.5-0.1-0.4-0.5-0.3-0.20.3-0.50.2-0.2-0.4-0.1-0.2-0.1-0.3
Cocaine response before conditioning0.10.10.4-0.4-0.2-0.10.2-0.20.2-0.20.0-0.20.30.2-0.20.10.60.6
Saline control response2.12.97.0-2.31.5-1.2-1.1-2.6-1.51.6-1.61.62.02.0-2.2-1.80.10.1
Bone: connectivity density5.48.712.13.5-3.32.92.93.33.0-3.03.3-3.0-2.7-2.82.82.52.32.4
Bone: cortical apparent density0.30.50.9-0.80.4-0.9-0.7-0.6-0.70.7-0.30.70.70.7-0.6-1.0-0.40.8
Bone: cortical area0.71.22.71.4-1.21.61.41.01.5-0.90.4-0.9-0.5-0.51.11.21.1-0.3
Bone: cortical porosity1.51.73.40.8-1.00.81.20.91.2-1.21.4-1.1-1.8-1.81.21.01.41.7
Bone: cortical porosity1.61.73.11.0-1.10.91.21.31.4-1.31.3-1.2-1.7-1.71.51.21.21.2
Bone: cortical thickness1.01.63.2-1.21.0-0.7-0.9-1.5-0.91.4-1.71.41.81.7-1.3-1.0-0.6-1.4
Bone: cortical thickness1.61.93.6-1.61.1-1.4-1.2-1.6-1.21.4-1.41.41.91.8-1.5-1.4-0.6-0.5
Bone: cortical tissue density0.30.50.9-0.80.3-0.9-0.7-0.6-0.70.6-0.20.60.70.6-0.6-0.9-0.40.9
Condit. Reinf. active minus inactive responses0.10.20.7-0.40.3-0.9-0.30.2-0.20.2-0.40.00.20.20.20.3-0.6-0.7
Condit. Reinf. active-inactive response ratio0.20.31.1-0.10.4-0.8-0.50.5-0.40.3-0.30.00.30.30.10.1-1.0-0.9
Condit. Reinf. active responses0.10.10.5-0.50.6-0.4-0.2-0.4-0.10.3-0.70.20.20.2-0.10.1-0.1-0.7
Condit. Reinf. inactive responses0.10.10.8-0.40.50.40.1-0.90.00.3-0.40.3-0.0-0.0-0.4-0.30.60.1
Incentive salience index mean0.91.12.1-1.41.2-1.4-1.0-0.9-0.91.0-1.30.81.01.0-0.8-0.4-0.9-1.4
Condit. Reinf. lever presses2.43.75.5-2.32.3-1.9-1.8-2.3-1.92.0-2.11.81.81.8-1.9-1.6-1.4-1.5
Condit. Reinf. active minus inactive responses2.03.13.91.6-1.82.01.91.11.9-1.81.7-1.9-1.7-1.81.61.92.01.3
Condit. Reinf. active-inactive response ratio1.11.82.31.2-1.51.51.30.71.2-1.31.5-1.4-1.4-1.41.11.31.51.3
Condit. Reinf. active responses0.40.62.50.9-0.71.61.10.00.9-0.70.4-0.7-0.1-0.20.40.71.10.2
Condit. Reinf. inactive responses1.01.53.6-0.71.2-0.2-0.8-1.1-0.71.2-1.51.21.91.8-1.2-1.1-0.8-1.6
Condit. Reinf. lever presses0.30.41.5-0.50.1-0.4-0.5-0.6-0.60.6-0.50.61.21.2-0.7-0.7-0.3-0.3
Condit. Reinf. lever reinforcers received0.20.31.40.5-0.41.20.7-0.30.6-0.40.2-0.40.20.1-0.00.40.90.2
Conditioned reinforcement - actives0.10.62.50.9-1.20.30.51.60.8-0.60.6-0.8-0.1-0.10.80.70.2-0.0
Conditioned reinforcement - inactives0.82.35.31.5-2.00.81.32.31.7-1.51.5-1.6-1.3-1.31.71.61.00.9
Conditioned locomotion0.10.10.70.7-0.00.40.10.80.5-0.10.0-0.10.20.20.3-0.2-0.1-0.0
Patch foraging indifference point 0 sec0.51.53.0-0.61.0-1.1-1.3-0.3-1.01.2-1.31.01.71.7-0.9-0.9-1.6-1.6
Patch foraging indifference point AUC1.94.67.2-2.41.9-2.1-2.1-2.3-1.92.2-2.42.22.72.5-2.3-2.4-1.2-0.9
Delay disc. indifference point, 0s delay1.71.95.10.6-1.21.21.20.31.1-1.81.5-1.7-0.9-0.90.71.12.22.3
Delay disc. indifference point, 16s delay0.30.41.0-0.60.2-0.5-0.5-0.6-0.50.7-0.60.40.70.6-0.9-1.0-0.10.2
Delay disc. indifference point, 2s delay0.20.22.10.0-0.40.2-0.1-0.3-0.0-0.20.5-0.10.00.1-0.2-0.50.61.4
Delay disc. indifference point, 24s delay0.71.22.3-1.50.8-1.3-1.1-1.3-0.91.3-1.31.20.90.9-1.0-1.2-0.5-0.3
Delay disc. indifference point, 4s delay0.40.41.1-1.00.1-0.5-0.5-1.1-0.50.3-0.30.20.50.4-0.8-0.70.71.0
Delay disc. indifference point, 8s delay1.22.13.8-1.70.9-1.4-1.6-1.9-1.71.4-1.31.31.31.3-1.8-1.9-0.70.1
Indifference point function ln k1.85.67.42.7-2.22.32.52.62.3-2.42.4-2.5-2.7-2.62.62.71.40.8
Indifference point function log k1.85.67.42.7-2.22.32.52.62.3-2.42.4-2.5-2.7-2.62.62.71.40.8
Patch foraging total patch changes 0 sec0.51.42.9-0.50.9-1.0-1.3-0.3-1.01.1-1.30.91.71.7-0.9-1.0-1.6-1.6
Patch foraging total patch changes 12 sec4.76.29.8-2.42.3-2.5-2.7-2.2-2.52.5-2.52.43.13.0-2.6-2.8-2.1-1.3
Patch foraging total patch changes 18 sec0.71.63.5-1.31.1-1.3-1.4-1.1-1.31.1-1.01.11.91.7-1.4-1.6-0.8-0.2
Patch foraging total patch changes 24 sec0.41.32.8-1.00.8-1.0-1.2-0.9-0.80.9-1.50.91.71.7-0.8-1.0-0.9-1.3
Patch foraging total patch changes 6 sec3.96.711.6-2.21.9-2.8-2.8-1.5-2.42.6-2.82.63.43.3-2.2-2.5-2.7-2.3
Patch foraging time to switch 0 sec0.31.12.0-1.30.8-1.4-1.3-1.1-1.41.1-0.71.20.70.7-1.2-1.0-0.8-0.3
Patch foraging water rate 0 sec0.51.82.71.5-0.91.31.51.71.6-1.51.1-1.6-1.1-1.21.61.50.80.5
Patch foraging water rate 12 sec0.20.82.21.1-0.80.61.01.51.0-0.90.6-0.8-0.7-0.71.31.30.1-0.5
Patch foraging water rate 18 sec0.81.83.21.3-1.01.01.61.71.6-1.31.1-1.5-1.4-1.41.81.70.90.3
Patch foraging water rate 24 sec0.70.91.30.9-1.21.11.10.81.1-0.80.7-0.9-1.1-1.11.11.21.00.2
Patch foraging water rate 6 sec0.10.20.50.7-0.50.30.40.70.4-0.30.3-0.4-0.4-0.50.40.3-0.10.1
Seeking ratio, delayed vs. immediate footshock0.10.20.6-0.50.3-0.4-0.3-0.4-0.30.1-0.60.30.70.7-0.5-0.0-0.2-0.7
Distance traveled before self-admin0.40.81.70.5-1.00.10.81.20.8-1.21.0-1.2-0.6-0.61.11.30.60.7
Distance traveled after self-admin1.73.05.71.6-2.11.11.61.81.6-1.92.1-1.8-1.6-1.61.61.21.52.4
Extensor digitorum longus weight0.31.13.50.3-0.61.31.5-0.21.3-0.90.6-0.7-1.1-1.00.91.21.90.8
Bone: elastic displacement0.20.21.30.30.5-0.1-0.10.2-0.3-0.40.8-0.4-0.2-0.2-0.2-0.4-0.31.2
Bone: elastic work0.70.93.01.0-0.50.40.71.10.6-1.21.6-1.2-0.8-0.70.60.40.41.7
Bone: endosteal estimation4.811.615.74.0-3.83.63.43.83.9-3.43.0-3.4-3.5-3.43.73.12.71.8
Bone: endosteal perimeter4.410.815.33.9-3.93.63.43.63.6-3.43.1-3.3-3.2-3.13.23.02.61.8
Epididymis fat weight0.42.36.41.8-1.42.51.70.61.6-1.61.5-1.6-1.1-1.11.01.01.61.3
Delta time in closed arm before/after self-admin0.60.61.7-0.30.9-0.6-0.9-0.3-0.30.9-1.10.90.30.3-0.3-0.6-1.1-1.3
Delta time in open arm before/after self-admin1.21.44.00.5-1.30.41.21.00.8-1.41.5-1.4-1.1-1.10.90.91.32.0
Diff in mean of infusions in LGA sessions0.91.62.31.3-0.81.31.31.31.5-1.41.2-1.4-1.3-1.31.41.21.21.1
Delay discount exponential model param0.30.41.00.90.10.60.71.00.6-0.50.5-0.4-0.6-0.60.91.0-0.2-0.7
Extinction: sum of active levers before priming0.10.10.8-0.10.2-0.3-0.00.10.40.4-0.70.40.10.10.30.2-0.2-0.9
Active lever presses in extinction session 64.64.67.51.3-2.61.52.31.22.0-2.12.2-2.1-2.6-2.61.72.02.72.5
Bone: final force0.10.20.70.6-0.80.40.40.70.7-0.1-0.2-0.1-0.3-0.30.50.50.2-0.7
Bone: final moment0.20.30.70.8-0.80.50.30.80.7-0.1-0.2-0.1-0.4-0.40.60.4-0.0-0.8
Food consumed during 24 hour testing period0.20.31.6-0.10.2-0.8-0.60.5-0.20.6-0.60.50.20.20.10.0-1.0-1.3
Glucose0.10.10.50.4-0.10.30.20.50.4-0.2-0.1-0.2-0.1-0.00.50.5-0.2-0.7
Heart weight0.60.93.60.41.1-0.1-1.00.4-0.31.0-1.00.90.60.50.1-1.0-1.9-1.6
Delay discount hyperbolic model param0.30.40.80.80.10.50.70.90.6-0.40.3-0.3-0.5-0.50.80.9-0.2-0.8
Intermittent access intake day 1-15 change0.52.77.92.3-1.91.51.52.81.5-1.81.6-1.7-1.0-1.01.81.90.5-0.1
Intermittent access intake escalation0.74.09.12.6-2.41.92.03.01.9-2.22.1-2.1-1.3-1.32.12.31.00.3
Intermittent access intake escalation 23.15.111.62.6-2.51.72.23.42.0-2.62.5-2.4-1.7-1.72.52.71.20.7
Intermitt. access day 1 inactive lever presses0.00.20.80.40.20.20.20.50.3-0.60.7-0.6-0.5-0.50.40.20.30.9
Intermitt. access day 15 inactive lever presses0.31.53.21.8-0.81.71.11.41.5-1.11.1-1.3-1.1-1.11.20.60.81.0
Intermitt. access escalation Index0.10.20.50.3-0.10.70.40.0-0.0-0.70.5-0.7-0.5-0.50.30.50.20.3
Intermittent access day 1 total infusions0.31.01.81.1-0.71.01.01.01.3-1.01.0-1.0-0.9-0.90.90.81.11.2
Intermittent access day 15 total infusions1.53.67.32.5-1.82.12.02.72.1-1.91.7-2.0-1.4-1.42.02.11.20.2
Intermittent access terminal intake (last 3 days)2.13.77.62.5-1.82.01.92.82.1-2.01.9-2.0-1.5-1.52.02.01.20.7
Intermittent access total infusions1.51.83.11.8-1.01.71.51.71.7-1.31.3-1.4-1.1-1.11.31.31.10.7
Intermittent access day 1 locomotion0.30.50.90.9-0.60.80.60.70.9-0.50.6-0.5-0.9-0.90.70.50.60.5
Intermittent access day 15 total locomotion0.00.10.50.7-0.30.40.30.70.5-0.10.2-0.0-0.1-0.20.1-0.10.20.1
Intermittent access total locomotion0.80.91.41.1-0.91.01.01.01.2-0.71.0-0.7-0.9-1.00.70.61.11.1
Intermittent access standard deviation0.63.410.02.3-1.91.41.73.22.1-1.91.4-1.8-1.3-1.32.42.10.6-0.1
Left kidney weight0.00.41.9-0.2-0.1-0.0-0.5-0.3-0.10.9-1.20.80.30.2-0.2-0.5-0.5-1.4
Right kidney weight0.32.36.0-1.21.2-1.1-1.5-1.2-1.11.8-2.21.81.41.3-1.2-1.3-1.5-2.5
Cocaine induced anxiety0.71.93.11.0-1.11.51.20.61.1-1.61.5-1.6-1.8-1.71.01.31.61.5
Post-drug Anxiety0.10.11.00.30.51.0-0.2-0.6-0.2-0.1-0.1-0.1-0.2-0.2-0.3-0.30.1-0.1
Baseline Anxiety1.22.03.6-0.61.4-0.6-1.4-1.0-1.01.7-1.81.61.51.5-1.1-1.6-1.7-1.9
Tail length0.00.20.8-0.0-0.20.4-0.0-0.10.60.0-0.90.10.50.40.30.20.4-0.9
Length with tail0.10.31.30.1-0.70.70.2-0.20.70.2-1.10.30.40.40.2-0.10.5-1.0
Length without tail0.21.32.70.9-1.61.71.40.41.5-0.70.2-0.7-1.3-1.20.90.61.50.4
Times rat made contact with spout0.40.52.30.1-0.50.30.60.20.6-0.70.8-0.6-0.6-0.70.50.41.01.5
Lifetime Intake1.11.42.61.6-0.91.51.31.41.6-1.11.2-1.2-0.8-0.81.01.01.10.8
Liver weight, left0.20.31.5-0.30.20.1-0.3-0.5-0.20.8-1.00.70.50.4-0.4-0.5-0.4-1.2
Liver weight, right0.50.81.61.1-1.21.20.80.91.1-0.70.5-0.8-0.9-0.91.00.50.80.3
Locomotor activity0.20.31.10.5-0.2-0.30.31.00.3-0.80.8-0.9-0.2-0.20.50.7-0.10.2
Locomotor testing distance0.10.31.50.4-0.2-0.60.11.20.1-0.70.7-0.80.10.10.40.5-0.40.1
Locomotor testing rearing0.41.42.60.9-0.90.71.41.31.2-1.61.4-1.6-0.7-0.71.11.51.31.0
Locomotion in novel chamber3.75.07.32.2-2.22.02.42.12.1-2.12.7-2.2-2.6-2.62.02.32.11.9
Locomotion in novel chamber post-restriction0.10.20.5-0.6-0.2-0.20.1-0.7-0.00.6-0.50.70.20.3-0.4-0.20.5-0.2
Fecal boli incidents, locomotor time 10.61.62.70.8-1.20.91.30.71.4-1.21.3-1.4-1.2-1.41.01.21.61.6
Change in fecal boli incidents, locomotor task1.41.52.2-1.21.2-1.2-1.2-1.1-1.31.0-1.31.21.31.5-1.4-1.0-1.2-1.3
Time >=10cm from walls, locomotor time 10.30.32.7-0.4-0.3-0.10.30.20.40.1-0.90.3-0.0-0.10.60.80.0-1.6
Bouts of movement, locomotor time 10.10.10.5-0.1-0.50.20.2-0.5-0.3-0.10.1-0.30.30.3-0.7-0.20.50.2
Total resting periods, locomotor time 10.10.20.5-0.4-0.50.00.1-0.6-0.3-0.0-0.0-0.30.40.3-0.7-0.30.50.3
Rest time, locomotor task time 10.30.52.1-0.0-1.20.20.4-0.20.0-0.80.7-1.2-0.1-0.2-0.2-0.20.91.4
Distance moved, locomotor task time 10.41.13.2-0.71.6-0.9-0.9-0.4-0.31.1-1.41.40.81.0-0.2-0.2-1.1-1.8
Vertical activity count, locomotor time 10.11.04.5-0.40.6-0.8-1.0-0.0-0.71.0-1.31.30.60.6-0.2-0.3-1.5-2.1
Time >=10cm from walls, locomotor time 20.10.20.7-0.4-0.6-0.10.40.10.3-0.6-0.2-0.5-0.2-0.10.50.80.5-0.3
Bouts of movement, locomotor time 20.41.43.5-1.70.8-1.9-1.2-1.1-1.40.9-0.60.91.61.4-1.4-1.0-0.50.3
Total resting periods, locomotor time 20.31.43.5-1.70.7-1.9-1.1-1.1-1.40.8-0.60.91.61.4-1.4-0.9-0.40.3
Rest time, locomotor task time 20.20.41.2-1.0-0.8-0.5-0.2-1.1-0.60.3-0.30.20.50.3-0.9-0.50.60.4
Distance moved, locomotor task time 20.30.30.90.60.60.50.40.70.8-0.5-0.0-0.2-0.5-0.31.00.9-0.1-0.6
Vertical activity count, locomotor time 20.10.21.00.50.1-0.1-0.21.00.3-0.3-0.1-0.3-0.5-0.40.70.4-0.8-0.6
Light reinforcement 10.10.30.7-0.30.0-0.2-0.4-0.7-0.50.7-0.10.60.70.8-0.8-0.80.10.5
Light reinforcement 20.51.02.5-1.10.6-1.0-1.0-1.3-1.31.0-0.41.10.60.7-1.3-1.6-0.60.9
Bone: marrow area5.012.116.34.0-3.93.73.53.83.9-3.53.1-3.5-3.5-3.53.73.12.82.0
Bone: maximum diameter6.112.217.14.0-4.14.13.93.43.8-3.63.2-3.5-3.2-3.23.33.33.21.9
Bone: maximum force1.02.04.11.8-2.01.51.51.71.7-1.11.1-1.1-1.1-1.11.41.31.10.4
Bone: maximum moment1.01.94.02.0-1.91.61.41.91.7-1.11.1-1.1-1.1-1.11.51.10.90.3
Mean time between licks in bursts0.20.92.7-0.31.1-0.6-0.9-0.1-0.80.7-0.90.61.21.2-0.6-0.6-1.7-1.5
Mean num. licks in bursts0.92.33.61.6-0.81.91.81.51.8-1.71.4-1.7-1.4-1.41.61.51.30.9
Cd content in liver1.21.33.0-0.61.3-1.2-1.3-0.2-1.21.1-0.81.11.11.4-0.9-0.9-1.7-1.3
Co content in liver2.12.54.8-0.62.0-0.9-1.6-0.7-1.41.5-1.51.61.92.1-1.2-1.4-2.2-1.8
Cu content in liver3.84.59.1-2.01.5-2.4-2.5-1.7-2.42.2-2.02.12.02.2-2.3-3.0-2.0-0.5
Fe content in liver2.22.73.7-1.81.9-1.9-1.9-1.5-1.91.7-1.61.61.41.4-1.7-1.7-1.6-1.2
K content in liver0.30.31.4-1.20.4-0.9-0.1-0.8-0.40.2-0.20.0-0.2-0.2-0.4-0.20.50.6
Mg content in liver0.30.31.2-1.00.7-1.1-0.5-0.6-0.70.6-0.40.3-0.1-0.1-0.4-0.5-0.3-0.0
Mn content in liver1.21.32.6-1.60.7-1.5-1.0-1.4-1.51.3-0.51.40.50.5-1.3-1.6-0.40.7
Na content in liver1.11.23.3-1.81.3-1.5-1.0-1.5-1.21.1-1.00.90.60.6-1.2-0.9-0.4-0.1
Rb content in liver0.20.20.50.4-0.40.40.30.50.5-0.30.0-0.5-0.7-0.60.70.30.1-0.2
Se content in liver18.722.135.1-5.34.6-5.9-5.4-4.2-5.44.9-4.24.94.14.1-4.7-4.9-4.6-2.4
Sr content in liver0.30.20.9-0.10.3-0.8-0.50.5-0.50.4-0.10.40.50.4-0.2-0.4-0.9-0.3
Zn content in liver2.32.66.6-2.21.8-2.6-1.9-1.5-1.81.6-1.51.31.01.2-1.3-1.5-1.5-0.6
Bone: minimum diameter6.312.217.54.2-3.64.13.83.94.1-3.52.9-3.5-3.2-3.13.83.72.81.0
Time in familiar zone, hab. session 10.40.41.01.0-1.00.60.20.70.5-0.60.7-0.4-0.7-0.70.40.10.30.8
Time in novel zone, hab. session 10.30.41.1-1.00.9-0.8-0.4-0.7-0.50.6-0.60.50.70.7-0.5-0.3-0.1-0.2
Total zone transitions, hab. session 10.00.00.1-0.1-0.4-0.20.20.0-0.00.10.2-0.1-0.1-0.1-0.2-0.10.20.3
Total locomotion distance, hab. session 10.91.32.1-1.40.9-1.5-1.1-1.3-1.31.2-0.91.01.21.2-1.4-1.1-0.7-0.4
Locomotion velocity, hab. session 12.02.84.2-2.11.5-2.0-1.6-2.0-1.81.8-1.51.61.81.8-2.0-1.6-1.0-0.9
Time in familiar zone, hab. session 20.20.30.80.10.4-0.1-0.5-0.1-0.40.3-0.30.40.90.9-0.5-0.6-0.8-0.3
Time in novel zone, hab. session 20.00.00.1-0.2-0.0-0.10.00.10.10.0-0.0-0.0-0.3-0.30.20.10.20.0
Total zone transitions, hab. session 20.70.91.3-0.80.7-1.0-0.8-0.7-1.01.1-0.91.11.01.0-1.1-1.0-1.0-0.9
Total locomotion distance, hab. session 21.21.62.1-1.11.1-1.2-1.1-1.2-1.21.4-1.21.41.41.4-1.4-1.2-1.2-1.1
Locomotion velocity, hab. session 21.31.72.6-1.31.2-1.4-1.2-1.4-1.31.5-1.21.51.41.4-1.6-1.3-1.0-0.9
Novel to familiar place preference ratio4.15.410.11.6-3.21.42.12.02.1-2.42.4-2.4-2.6-2.62.42.12.42.6
Novelty place preference4.45.610.41.7-3.21.52.12.12.2-2.42.5-2.4-2.6-2.62.52.12.52.7
Time in novel zone, NPP test4.75.710.11.7-3.21.52.22.12.2-2.52.5-2.5-2.6-2.62.52.22.42.6
Total zone transitions, NPP test1.01.42.1-1.41.3-1.3-1.1-1.3-1.11.4-1.41.30.90.9-1.1-1.0-1.0-1.2
Total locomotion distance, NPP test2.23.14.3-2.01.6-2.1-1.8-1.9-1.81.9-1.81.91.81.8-1.9-1.6-1.4-1.2
Locomotion velocity, NPP test2.23.24.6-2.11.7-2.1-1.7-2.0-1.81.9-1.81.91.81.8-1.8-1.6-1.3-1.2
Intraocular pressure0.20.20.6-0.00.1-0.0-0.6-0.5-0.30.7-0.30.70.60.7-0.6-0.8-0.20.1
Delta distance traveled before/after self-admin1.61.73.01.5-1.41.71.21.01.4-1.21.3-1.0-1.4-1.41.10.51.41.7
Delta ambulatory time before/after self-admin1.52.64.51.8-1.62.11.71.21.7-1.51.6-1.3-1.7-1.71.40.91.71.9
Parametrial fat weight0.71.62.6-1.51.5-1.1-1.1-1.4-1.01.3-1.61.21.41.4-1.2-0.9-0.9-1.3
Pavlov. Cond. lever latency0.10.10.80.9-0.30.60.00.60.0-0.20.40.10.20.20.0-0.4-0.30.3
Pavlov. Cond. magazine entry latency1.11.44.3-1.01.1-1.7-1.3-0.2-0.91.1-1.51.00.70.7-0.4-0.3-1.7-2.1
Pavlov. Cond. change in total contacts0.40.42.3-0.20.4-0.9-0.50.6-0.20.5-0.50.1-0.0-0.00.50.5-1.1-1.5
Pavlov. Cond. index score0.60.72.0-1.20.7-1.4-0.8-0.5-0.60.9-1.10.60.40.4-0.30.0-0.7-1.4
Pavlov. Cond. latency score0.40.61.6-1.20.6-1.3-0.6-0.7-0.50.8-1.00.50.30.3-0.30.1-0.4-1.2
Pavlov. Cond. lever contacts0.50.71.7-1.30.8-1.1-0.7-1.0-0.70.9-1.10.60.40.4-0.6-0.2-0.4-1.0
Pavlov. Cond. magazine entry number0.40.52.80.2-0.51.00.7-0.40.3-0.50.8-0.5-0.0-0.0-0.2-0.21.31.7
Pavlov. Cond. intertrial magazine entries0.10.10.5-0.30.20.40.1-0.7-0.10.2-0.10.00.30.3-0.3-0.10.50.0
Pavlov. Cond. lever-magazine prob. diff.0.60.72.2-1.20.8-1.5-0.8-0.5-0.70.8-1.10.60.40.4-0.30.0-0.8-1.4
Pavlov. Cond. response bias0.60.73.0-0.50.7-1.4-0.90.3-0.60.8-1.00.50.20.20.00.0-1.5-1.7
Pavlov. Cond. lever latency1.41.92.71.0-1.01.11.60.91.2-1.61.6-1.6-1.6-1.61.11.61.51.4
Pavlov. Cond. magazine entry latency0.40.62.0-0.50.8-0.9-1.00.0-0.50.7-0.90.70.30.30.1-0.1-1.2-1.4
Pavlov. Cond. change in total contacts0.41.01.8-1.01.0-0.9-1.1-1.0-0.81.0-1.41.01.11.2-0.9-0.9-0.8-1.0
Pavlov. Cond. index score0.81.32.4-0.90.8-1.0-1.4-0.7-0.91.2-1.51.31.21.2-0.6-0.9-1.2-1.4
Pavlov. Cond. latency score0.50.91.9-0.70.6-0.8-1.2-0.5-0.71.0-1.31.10.91.0-0.4-0.7-1.0-1.4
Pavlov. Cond. lever contacts1.62.33.5-1.11.2-1.1-1.7-1.2-1.31.7-1.81.71.81.9-1.3-1.8-1.5-1.4
Pavlov. Cond. magazine entry number2.12.74.41.6-2.01.81.91.11.4-1.72.1-1.6-1.4-1.41.11.21.82.1
Pavlov. Cond. intertrial magazine entries0.92.03.51.1-1.31.51.70.71.4-1.51.5-1.5-1.3-1.41.11.51.91.5
Pavlov. Cond. lever-magazine prob. diff.0.71.02.0-0.90.7-1.0-1.2-0.6-0.81.1-1.41.11.01.1-0.5-0.8-1.1-1.3
Pavlov. Cond. response bias1.62.33.5-1.21.4-1.4-1.8-1.0-1.31.6-1.91.61.71.7-1.0-1.5-1.7-1.6
Time in closed arm before self-admin0.71.32.20.7-1.50.51.20.90.9-1.31.5-1.2-1.0-1.01.01.21.21.4
Time in closed arm after self-admin0.10.10.6-0.60.3-0.5-0.2-0.8-0.20.3-0.30.40.30.3-0.4-0.20.10.1
Time in open arm before self-admin0.20.20.90.11.00.2-0.4-0.4-0.40.5-0.30.40.30.3-0.5-0.6-0.6-0.5
Time in open arm after self-admin0.10.10.40.2-0.5-0.10.10.5-0.0-0.30.5-0.4-0.1-0.10.0-0.10.20.7
Bone: periosteal estimation3.27.711.23.4-3.33.33.03.03.3-2.72.3-2.7-2.5-2.42.92.52.41.2
Bone: periosteal perimeter3.06.08.92.9-2.83.02.82.42.8-2.52.1-2.5-2.1-2.12.32.42.31.1
Bone: post-yield work1.42.55.42.0-2.31.71.61.91.9-1.11.2-1.2-1.3-1.31.81.61.20.3
Progressive ratio test 1 active lever presses0.30.50.91.0-0.60.90.80.80.9-0.50.8-0.6-0.3-0.30.30.20.70.7
Progressive ratio test 1 breakpoint0.10.30.50.7-0.40.70.60.60.7-0.30.6-0.4-0.1-0.10.10.10.60.6
Progressive ratio test 1 inactive lever presses0.71.82.61.6-1.11.31.41.61.6-1.31.5-1.4-1.1-1.21.31.01.21.3
Progressive ratio test 2 active lever presses2.63.65.62.4-2.22.01.92.42.2-2.02.0-2.0-1.5-1.51.61.51.71.4
Progressive ratio test 2 breakpoint3.03.86.02.4-2.22.12.02.42.2-2.12.0-2.1-1.4-1.51.71.61.71.4
Progressive ratio test 2 inactive lever presses0.72.23.41.8-1.41.41.51.81.6-1.61.8-1.7-1.1-1.21.21.11.31.6
Incentive Sensitization - Responses1.74.78.02.5-2.51.92.02.82.3-2.42.2-2.3-1.9-1.92.12.01.71.4
Incentive Sensitization - Breakpoint1.94.47.72.5-2.51.91.92.82.3-2.32.1-2.2-1.8-1.82.12.01.61.2
Sum of active levers in priming session hrs 5-60.40.31.2-0.20.8-0.9-0.90.1-0.60.4-0.40.40.40.4-0.3-0.6-1.1-0.4
Progressive ratio0.20.62.4-0.71.5-0.0-0.5-1.3-0.60.6-0.80.70.50.6-0.9-0.4-0.2-1.0
Food seeking constrained by brief footshock0.30.32.60.1-0.1-0.3-0.00.60.20.2-0.50.30.60.70.20.7-0.2-1.6
Seeking ratio, punishment vs. effort0.10.21.20.1-0.7-0.8-0.21.10.30.1-0.20.10.40.40.50.2-0.4-0.4
Retroperitoneal fat weight0.10.31.1-0.10.30.6-0.2-1.0-0.10.5-0.60.50.60.6-0.4-0.8-0.1-0.1
Reaction time number correct1.14.06.11.7-2.12.02.21.41.6-2.12.1-2.1-2.5-2.41.61.82.11.7
Reaction time mean minus median0.10.83.21.2-0.30.2-0.11.80.5-0.30.1-0.3-0.5-0.41.00.9-1.2-1.6
Reaction time mean minus median AUC0.10.62.41.0-0.10.1-0.31.40.1-0.30.0-0.2-0.5-0.50.80.6-1.4-1.6
Reaction time num false alarms0.20.31.0-0.60.40.1-0.2-1.0-0.00.6-0.80.40.80.7-0.4-0.30.4-0.5
Reaction time num false alarms AUC0.10.30.9-0.60.5-0.1-0.3-0.8-0.10.6-1.00.40.80.7-0.3-0.20.1-0.8
Reaction time trials correct on left1.14.06.11.7-2.12.02.21.41.6-2.12.1-2.1-2.5-2.41.61.82.11.7
Reaction time trials on left1.13.85.91.7-2.02.02.21.31.6-2.12.1-2.1-2.4-2.41.61.82.01.6
Reaction time mean0.81.74.6-0.61.6-1.4-1.50.1-0.81.3-1.41.11.21.3-0.4-0.6-2.2-2.1
Reaction time mean AUC0.92.35.6-0.81.8-1.7-1.8-0.2-1.11.6-1.61.51.41.5-0.7-0.9-2.4-2.2
Median of all reaction times1.21.93.8-0.91.8-1.6-1.6-0.4-0.91.4-1.41.31.41.5-0.7-0.9-2.0-1.7
Reaction time omissions0.40.62.30.80.20.40.21.00.5-0.50.1-0.5-0.8-0.71.11.2-0.6-1.5
Reaction time false alarm rate1.41.93.5-1.31.3-1.0-1.3-1.4-0.81.5-1.81.41.91.7-1.1-1.1-0.8-1.4
Reaction time premature initiation rate0.71.13.3-0.90.6-0.7-0.9-0.8-0.71.1-1.61.11.41.2-0.7-0.6-0.9-1.8
Reaction time premature initiations0.10.21.00.1-0.50.50.4-0.10.2-0.0-0.4-0.10.1-0.10.20.50.3-1.0
Std. dev. reaction times0.31.26.80.60.7-0.6-1.01.2-0.20.5-0.90.50.40.50.40.2-2.2-2.6
Reaction time trials completed1.13.85.91.7-2.02.02.21.31.6-2.12.1-2.1-2.4-2.41.61.82.01.6
Reaction time trials AUC1.03.55.71.5-1.91.92.11.21.5-2.02.0-2.0-2.4-2.31.51.72.01.6
Run reversals in cocaine runway, females0.20.20.6-0.30.1-0.8-0.6-0.1-0.40.5-0.10.60.40.4-0.4-0.7-0.40.4
Run reversals in cocaine runway, males3.03.44.6-1.91.8-1.6-1.7-1.7-1.82.1-2.02.12.12.1-1.7-1.6-1.4-1.6
Latency to leave start box in cocaine runway1.42.03.21.8-0.61.81.61.31.5-1.51.6-1.4-1.3-1.31.41.71.10.5
Latency to leave start box in cocaine runway, F2.53.14.41.9-1.01.92.11.61.9-2.02.0-1.9-1.5-1.51.72.11.51.1
Latency to leave start box in cocaine runway, M0.10.10.40.6-0.00.50.10.20.2-0.20.2-0.2-0.3-0.40.20.3-0.1-0.4
Std. dev. time between licks in bursts1.83.34.3-1.41.8-1.4-2.0-1.7-1.92.1-1.82.01.91.9-1.8-2.1-2.0-1.4
Total sessions with >9 infusions0.20.20.9-0.20.2-0.1-0.4-0.4-0.10.4-0.20.40.70.7-0.6-0.90.00.6
Short access day 1 total inactive lever presses1.83.58.42.0-1.61.91.91.41.8-1.72.5-1.8-1.8-1.81.31.12.02.9
Short access day 10 total inactive lever presses0.00.10.3-0.30.00.10.0-0.2-0.0-0.50.1-0.4-0.1-0.10.10.30.40.4
Short access day 1 total infusions0.10.20.9-0.20.1-0.1-0.4-0.5-0.20.5-0.10.30.50.5-0.7-0.90.00.7
Short access day 10 total infusions0.40.61.4-0.41.2-0.5-0.7-0.5-0.40.8-0.60.71.11.1-0.8-1.0-0.6-0.2
Short access total infusions0.20.31.10.7-0.50.70.50.50.8-0.40.7-0.5-0.1-0.10.30.00.71.1
Short access day 1 locomotion0.20.33.20.1-0.20.30.2-0.20.3-0.20.7-0.3-0.3-0.2-0.2-0.50.81.8
Short access day 10 total locomotion0.00.20.7-0.50.1-0.8-0.5-0.3-0.30.5-0.20.5-0.1-0.2-0.3-0.3-0.30.2
Short access total locomotion0.10.21.3-0.20.3-0.4-0.3-0.2-0.10.20.20.20.10.1-0.3-0.80.01.1
One hour access (0.3 mA shock)5.46.410.73.1-3.12.62.53.32.8-2.62.4-2.6-2.2-2.22.52.31.91.2
Compulsive drug intake0.91.42.21.0-1.51.41.10.91.1-1.41.0-1.4-1.0-1.01.41.31.00.7
One hour access (shock baseline)0.20.61.71.2-0.60.80.71.31.1-0.60.5-0.6-0.6-0.60.60.60.5-0.0
Social response proportion2.63.34.71.8-1.61.71.91.71.7-1.92.2-2.0-2.2-2.11.61.41.52.0
Social responses0.70.91.91.4-0.91.21.01.11.0-0.61.1-0.9-0.6-0.70.70.30.71.0
Social time0.50.81.7-1.11.3-0.8-0.7-1.0-0.81.1-0.90.90.70.8-0.8-0.9-0.5-0.4
Soleus weight1.44.26.52.5-2.12.42.02.02.2-1.81.8-1.8-2.4-2.62.11.61.51.1
Bone: stiffness1.12.03.61.4-1.81.71.81.11.9-1.20.9-1.2-1.1-1.11.51.61.80.5
Tibialis anterior weight0.82.77.50.6-1.41.72.00.11.8-1.71.2-1.6-1.9-1.91.31.82.71.6
Time to tail flick, vehicle, before self-admin0.30.42.4-0.5-0.0-0.4-0.5-0.7-0.60.30.30.30.20.2-0.7-1.10.21.5
Time to tail flick, vehicle, after self-admin0.20.41.9-0.3-0.40.30.5-0.40.7-0.50.1-0.6-0.5-0.50.40.71.40.5
Time to tail flick, test, before self-admin0.91.12.11.1-1.40.81.01.11.4-0.80.8-0.9-1.1-1.11.21.00.90.7
Time to tail flick, test, after self-admin0.30.32.5-0.3-0.10.00.0-0.4-0.0-0.50.4-0.4-0.2-0.2-0.0-0.30.71.6
Delta time to tail flick, vehicle, before/after SA0.91.02.90.2-0.60.91.20.11.3-0.90.2-0.9-0.9-0.91.01.61.7-0.1
Delta time to tail flick, test, before/after SA0.20.20.6-0.60.4-0.3-0.4-0.8-0.70.0-0.00.20.50.5-0.6-0.60.10.7
Tibia length0.10.41.1-0.30.5-0.4-0.7-0.1-0.40.7-0.90.70.40.4-0.4-0.6-0.8-1.0
Ambulatory time before self-admin0.20.61.20.4-0.7-0.10.71.10.5-1.11.0-1.1-0.4-0.40.91.10.40.6
Ambulatory time after self-admin3.65.88.82.1-2.81.72.42.42.3-2.72.9-2.5-2.3-2.32.32.02.23.0
Bone: tissue strength0.10.10.30.60.10.40.00.60.3-0.1-0.1-0.1-0.5-0.50.5-0.1-0.5-0.5
Total heroin consumption0.00.00.1-0.10.1-0.00.2-0.20.30.1-0.20.1-0.1-0.1-0.1-0.10.30.1
Bone: trabecular number2.85.38.73.0-2.82.52.22.82.4-2.32.4-2.4-1.9-2.02.21.91.71.6
Bone: trabecular spacing1.62.33.7-1.71.9-1.5-1.6-1.5-1.41.4-1.81.51.61.6-1.2-1.0-1.3-1.6
Bone: trabecular thickness2.43.35.52.3-2.12.12.02.12.0-1.91.8-2.0-1.4-1.41.71.71.40.9
Bone: trabecular tissue density0.61.11.81.0-1.21.31.30.71.1-1.11.1-1.0-0.8-0.71.00.91.31.2
Water consumed over 24 hours0.61.22.30.4-1.30.31.00.81.1-1.21.2-1.2-1.0-1.11.11.21.41.5
Number of responses in last shaping day0.10.21.00.50.10.6-0.3-0.0-0.40.10.20.10.20.2-0.6-1.0-0.30.5