Hub : Genes

Myof

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Myof 0.2 0.07 0.0e+00 0.25 0.25 0.26 0.25 8.9e-27 3.3e-27 2.1e-28 1.0e-27
2 Liver gene expression Myof 0.04 0.02 9.1e-04 0.01 0.01 0 0 5.4e-02 9.5e-03 2.2e-01 1.4e-01
3 LHb isoform ratio XM_006231325.4 0.23 0.15 1.6e-03 0.03 0.1 0.04 0.05 7.4e-02 1.9e-03 4.8e-02 2.6e-02
4 PL mRNA stability Myof 0.06 0.03 5.9e-07 0.05 0.06 0.06 0.05 8.1e-06 3.5e-07 3.2e-07 5.2e-06
5 BLA mRNA stability Myof 0.08 0.06 4.8e-03 0 0.02 0.02 0 2.7e-01 1.9e-02 1.9e-02 1.9e-01
6 Brain gene expression Myof 0.13 0.05 1.7e-16 0.13 0.16 0.16 0.16 1.9e-12 1.6e-14 8.4e-15 4.1e-15
7 BLA gene expression Myof 0.08 0.04 1.2e-04 0.04 0.07 0.04 0.06 1.9e-03 1.2e-04 2.9e-03 3.1e-04
8 OFC mRNA stability Myof 0.22 0.14 3.7e-03 0.1 0.09 0.02 0.05 2.5e-03 4.0e-03 1.2e-01 2.2e-02
9 NAcc mRNA stability Myof 0.04 0.02 2.1e-04 0.04 0.04 0.03 0.04 3.2e-05 4.7e-05 7.2e-05 3.1e-05
10 NAcc gene expression Myof 0.06 0.03 2.7e-07 0.05 0.05 0.04 0.05 2.6e-06 6.7e-07 2.6e-05 4.2e-06
11 Adipose mRNA stability Myof 0.07 0.03 2.9e-08 0.07 0.06 0.06 0.06 3.3e-08 1.0e-06 3.7e-07 1.9e-07
12 Brain mRNA stability Myof 0.09 0.04 9.8e-08 0.05 0.07 0.05 0.07 1.9e-05 1.7e-07 2.4e-05 6.1e-07
13 IL gene expression Myof 0.62 0.16 1.7e-09 0.34 0.29 0.27 0.33 6.6e-09 8.5e-08 3.9e-07 1.3e-08
14 pVTA gene expression Myof 0.11 0.07 3.0e-03 0 0.05 0.03 0.02 2.9e-01 4.2e-03 2.9e-02 5.2e-02
15 Adipose gene expression Myof 0.28 0.09 0.0e+00 0.19 0.2 0.22 0.2 2.9e-20 2.2e-21 1.9e-23 1.3e-21
16 OFC gene expression Myof 0.26 0.11 9.8e-04 0.1 0.1 0.11 0.12 3.0e-03 3.0e-03 1.5e-03 1.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
Bone: apparent density4.88.112.1-3.53.13.1-3.02.83.12.7-3.12.82.9-2.82.9-3.22.1-1.52.3
Area under the delay curve0.40.41.10.0-1.0-0.90.3-1.1-0.1-0.8-0.3-0.4-0.40.3-0.10.9-0.40.80.7
BMI with tail0.41.43.1-1.11.01.6-0.71.80.71.2-0.91.51.0-1.31.0-1.50.9-0.81.5
BMI without tail1.12.33.7-1.31.71.9-1.51.81.01.7-1.51.71.4-1.81.1-1.21.0-1.91.0
Body weight0.31.32.6-1.20.81.4-1.11.51.31.3-1.00.91.2-0.81.5-0.91.6-0.60.4
Weight adjusted by age0.30.33.2-0.6-0.60.20.20.00.4-0.3-0.50.5-0.0-0.40.4-0.1-0.10.61.8
Bone surface3.66.49.7-3.03.12.9-2.92.42.82.6-2.72.42.5-2.52.4-2.61.8-1.71.6
Bone volume3.96.79.0-2.92.82.9-2.82.53.02.6-3.02.52.6-2.42.7-2.72.2-1.71.6
Breakpoint value in progressive ratio session0.20.31.00.0-0.9-0.80.0-1.00.5-0.4-0.4-0.5-0.20.50.40.20.40.50.2
Number of licking bursts1.01.22.60.7-1.4-1.50.9-1.5-1.0-1.30.4-1.0-0.91.0-0.81.1-1.60.50.7
Context. condit. distance diff. score1.62.03.2-1.61.01.2-1.71.51.81.5-1.21.41.6-1.41.7-1.01.7-0.90.8
Locomotion velocity, session 11.61.75.91.1-0.6-1.40.8-1.7-1.5-1.50.9-1.1-1.41.1-1.71.0-2.41.20.1
Locomotion distance, session 10.60.71.90.7-0.9-0.90.5-1.1-0.7-0.90.6-0.9-0.90.9-0.60.7-1.21.40.4
Locomotion velocity, session 20.70.82.5-1.11.60.2-1.50.10.60.6-1.20.90.8-1.00.1-1.1-0.5-0.90.2
Locomotion distance, session 20.10.10.6-0.3-0.0-0.4-0.5-0.40.3-0.1-0.80.00.2-0.10.2-0.3-0.40.30.0
Locomotion velocity, session 30.40.50.8-0.60.70.6-0.80.60.80.7-0.90.60.7-0.90.6-0.70.6-0.5-0.3
Locomotion distance, session 30.60.61.4-0.20.70.7-0.61.10.81.0-0.30.60.8-0.60.7-0.81.0-0.3-1.2
Stereotopy head waving bouts, day 30.30.31.7-0.60.70.7-0.70.50.20.3-0.40.50.3-0.60.2-0.4-0.30.21.3
Stereotopy head waving duration, day 30.40.54.5-0.80.40.6-0.80.40.30.3-0.50.60.3-0.60.4-0.60.2-0.42.1
Locomotion velocity, session 73.53.86.4-1.81.31.7-2.21.72.12.1-2.12.02.0-1.92.1-1.92.5-2.40.7
Locomotion distance, session 72.12.75.0-1.41.31.4-1.81.51.81.9-1.71.71.7-1.51.7-1.52.2-2.20.0
Stereotopy head waving bouts, day 70.20.21.4-0.70.50.1-0.30.20.1-0.1-0.00.40.2-0.4-0.1-0.1-0.60.21.2
Stereotopy head waving duration, day 70.20.20.7-0.60.80.6-0.20.70.10.10.10.50.2-0.5-0.2-0.3-0.40.00.8
Locomotion velocity, session 80.30.40.6-0.80.60.6-0.70.70.60.6-0.40.70.7-0.70.6-0.70.6-0.20.6
Locomotion distance, session 80.91.32.4-1.50.60.5-1.60.81.40.9-1.41.21.3-1.21.4-0.81.0-0.40.9
Degree of sensitization distance0.50.51.8-0.8-0.2-0.1-0.9-0.40.60.3-1.10.50.4-0.30.7-0.20.8-1.21.3
Degree of sensitization stereotypy0.20.20.8-0.30.3-0.30.3-0.1-0.4-0.50.7-0.2-0.20.1-0.60.3-0.90.80.1
Conditioned locomotion0.10.10.60.0-0.30.50.30.70.40.2-0.20.30.2-0.10.5-0.20.80.2-0.1
Cocaine response after cond. corrected0.20.20.50.1-0.2-0.40.3-0.4-0.4-0.40.6-0.6-0.40.5-0.50.7-0.60.2-0.6
Cocaine response after cond. not corrected0.10.10.4-0.2-0.2-0.50.0-0.3-0.1-0.20.3-0.4-0.00.3-0.20.6-0.2-0.1-0.5
Cocaine response before conditioning0.10.10.3-0.3-0.1-0.3-0.5-0.10.30.1-0.30.10.3-0.10.3-0.20.4-0.50.5
Saline control response2.22.97.01.7-2.6-2.31.7-2.4-1.3-2.11.2-1.7-1.61.6-0.91.2-0.72.00.5
Bone: connectivity density6.19.613.3-3.53.63.4-3.33.13.03.0-3.33.23.1-3.32.8-3.62.1-2.42.5
Bone: cortical apparent density1.01.32.10.8-1.0-1.11.2-1.0-1.4-1.21.5-0.8-1.10.8-1.31.3-1.30.31.2
Bone: cortical area0.91.42.8-1.01.11.2-1.61.11.61.4-1.20.71.2-0.71.5-0.71.7-0.9-0.5
Bone: cortical porosity0.80.91.9-1.20.60.5-1.20.40.80.7-1.21.00.8-1.00.8-1.20.6-0.81.4
Bone: cortical porosity1.21.42.3-1.41.20.9-1.50.71.11.1-1.41.21.2-1.31.0-1.30.9-1.30.8
Bone: cortical thickness0.91.52.41.3-1.5-1.30.9-1.2-1.0-1.21.1-1.6-1.11.5-0.81.5-0.61.3-1.2
Bone: cortical thickness1.61.82.81.2-1.7-1.71.1-1.6-1.3-1.51.3-1.5-1.21.6-1.01.5-1.41.2-0.2
Bone: cortical tissue density0.91.21.90.8-0.9-1.01.2-1.0-1.4-1.21.4-0.8-1.00.8-1.31.2-1.30.31.3
Condit. Reinf. active minus inactive responses0.20.21.30.60.0-0.50.4-0.4-0.3-0.10.0-0.2-0.10.4-0.30.4-0.5-0.4-1.1
Condit. Reinf. active-inactive response ratio0.30.41.50.70.2-0.30.9-0.2-0.5-0.30.6-0.3-0.40.6-0.80.6-0.8-0.1-1.2
Condit. Reinf. active responses0.10.10.80.5-0.3-0.40.2-0.3-0.00.0-0.1-0.30.00.20.10.10.2-0.2-0.9
Condit. Reinf. inactive responses0.10.10.4-0.1-0.7-0.3-0.2-0.20.1-0.1-0.3-0.30.1-0.10.5-0.30.50.20.4
Incentive salience index mean0.80.92.11.3-1.0-1.30.9-1.1-0.8-0.80.7-1.0-0.71.1-0.70.9-0.70.3-1.5
Condit. Reinf. lever presses2.33.05.12.2-2.3-2.21.9-2.0-1.6-1.81.6-1.9-1.71.8-1.41.4-1.11.4-1.0
Condit. Reinf. active minus inactive responses2.63.24.2-1.71.11.7-1.82.01.91.9-1.71.81.9-1.62.1-1.92.0-1.91.3
Condit. Reinf. active-inactive response ratio1.41.52.4-1.40.71.2-1.01.61.11.1-0.91.21.3-1.31.3-1.51.0-1.31.5
Condit. Reinf. active responses0.60.82.6-0.60.31.0-0.91.11.21.0-0.70.60.9-0.41.3-1.01.6-0.50.3
Condit. Reinf. inactive responses0.60.81.81.2-0.8-0.50.5-0.7-0.4-0.60.9-1.1-0.91.3-0.40.90.11.2-1.3
Condit. Reinf. lever presses0.20.20.60.4-0.5-0.50.4-0.6-0.5-0.60.5-0.6-0.50.8-0.40.3-0.40.3-0.0
Condit. Reinf. lever reinforcers received0.30.41.5-0.4-0.00.6-0.60.70.80.6-0.50.40.6-0.21.0-0.71.2-0.30.3
Conditioned reinforcement - actives0.90.92.6-1.61.40.7-1.10.81.00.8-1.10.81.2-0.90.8-0.90.5-0.1-0.4
Conditioned reinforcement - inactives3.33.77.3-2.62.71.7-2.61.82.02.0-1.62.02.3-1.81.7-1.71.2-1.20.4
Conditioned locomotion0.10.10.8-0.30.90.5-0.50.20.30.4-0.00.10.2-0.00.1-0.30.20.1-0.1
Patch foraging indifference point 0 sec0.60.91.71.2-0.4-0.80.8-1.0-0.9-0.90.4-1.1-0.90.9-1.01.1-1.20.8-1.3
Patch foraging indifference point AUC3.33.87.81.7-2.1-2.61.3-2.8-1.6-2.11.9-2.3-1.92.3-1.62.2-1.51.6-0.5
Delay disc. indifference point, 0s delay1.51.62.9-1.50.40.8-1.10.91.41.0-1.51.71.4-1.41.6-0.81.5-1.01.6
Delay disc. indifference point, 16s delay0.30.31.30.0-0.5-0.80.1-1.1-0.1-0.7-0.3-0.6-0.40.4-0.20.5-0.51.10.5
Delay disc. indifference point, 2s delay0.20.22.6-0.4-0.30.1-0.2-0.20.2-0.2-0.10.30.0-0.20.20.4-0.2-0.11.6
Delay disc. indifference point, 24s delay0.90.92.60.7-1.1-1.50.4-1.6-0.7-1.00.6-1.2-0.80.9-0.71.2-0.70.8-0.1
Delay disc. indifference point, 4s delay0.30.41.1-0.0-1.0-1.00.2-1.0-0.2-0.7-0.4-0.3-0.20.20.10.7-0.30.51.1
Delay disc. indifference point, 8s delay2.12.24.31.0-2.0-1.81.6-2.1-1.2-1.80.6-1.3-1.51.3-1.11.9-1.41.40.3
Indifference point function ln k4.15.79.5-2.02.62.9-2.13.12.22.6-2.42.52.4-2.82.1-2.72.0-2.00.1
Indifference point function log k4.15.79.5-2.02.62.9-2.13.12.22.6-2.42.52.4-2.82.1-2.72.0-2.00.1
Patch foraging total patch changes 0 sec0.50.81.91.1-0.3-0.70.8-0.9-0.8-0.80.2-1.1-0.90.7-0.91.0-1.00.6-1.4
Patch foraging total patch changes 12 sec4.25.47.12.3-2.2-2.52.4-2.7-2.5-2.52.3-2.5-2.42.4-2.32.6-2.42.0-0.6
Patch foraging total patch changes 18 sec0.70.91.90.7-0.9-1.20.6-1.4-1.0-1.20.4-1.0-0.90.9-0.91.2-1.20.50.4
Patch foraging total patch changes 24 sec0.50.61.90.9-0.7-1.00.3-1.3-0.4-0.70.1-0.9-0.70.9-0.51.1-0.40.4-1.4
Patch foraging total patch changes 6 sec3.55.27.72.3-1.5-2.41.9-2.7-2.3-2.32.1-2.7-2.22.5-2.32.8-2.51.6-1.7
Patch foraging time to switch 0 sec1.01.62.70.8-1.4-1.21.5-1.0-1.2-1.41.3-1.1-1.11.3-1.01.3-1.61.60.5
Patch foraging water rate 0 sec1.32.13.5-1.11.71.4-1.71.31.41.6-1.61.41.4-1.71.2-1.51.5-1.9-0.4
Patch foraging water rate 12 sec0.61.02.2-0.81.51.0-1.31.00.91.2-1.00.91.0-0.70.7-0.90.8-0.9-1.0
Patch foraging water rate 18 sec1.82.43.7-1.41.71.3-1.91.21.61.7-1.91.41.6-1.51.4-1.41.5-1.7-0.7
Patch foraging water rate 24 sec0.91.22.2-1.00.91.0-1.21.01.31.1-1.51.01.2-0.91.4-1.01.3-0.9-0.1
Patch foraging water rate 6 sec0.10.10.4-0.30.70.6-0.50.40.10.4-0.20.30.2-0.40.1-0.40.1-0.4-0.3
Seeking ratio, delayed vs. immediate footshock0.10.10.40.3-0.4-0.4-0.1-0.3-0.1-0.20.2-0.5-0.20.5-0.1-0.10.10.5-0.6
Distance traveled before self-admin1.01.02.6-0.91.10.5-0.80.61.30.9-1.61.21.1-1.10.8-1.20.7-1.2-0.1
Distance traveled after self-admin3.43.85.4-2.22.11.7-2.11.42.21.9-2.32.22.0-2.01.7-1.61.2-2.12.1
Extensor digitorum longus weight0.31.45.4-0.8-0.20.5-1.30.81.41.1-1.10.91.1-1.11.7-1.02.3-0.91.0
Bone: elastic displacement0.30.32.80.30.00.40.60.2-0.7-0.1-0.10.4-0.4-0.5-0.5-0.4-0.7-0.31.7
Bone: elastic work0.70.93.6-0.70.91.0-0.50.70.30.7-1.01.20.5-1.20.3-1.0-0.1-1.01.9
Bone: endosteal estimation5.712.517.9-3.83.93.8-4.23.24.13.9-3.73.33.5-3.23.6-3.23.6-3.11.3
Bone: endosteal perimeter5.411.215.3-3.73.83.7-3.93.13.83.6-3.73.33.4-3.13.5-2.83.1-2.71.3
Epididymis fat weight0.41.02.0-0.60.11.3-0.61.41.01.1-1.11.00.8-0.81.3-0.61.4-1.10.6
Delta time in closed arm before/after self-admin0.50.52.30.9-0.4-0.50.2-0.6-0.3-0.20.5-0.9-0.61.0-0.41.0-0.30.3-1.5
Delta time in open arm before/after self-admin1.31.22.4-1.60.90.6-1.10.71.00.8-1.31.41.2-1.40.9-1.10.7-1.11.4
Diff in mean of infusions in LGA sessions1.82.04.9-1.41.51.3-1.51.31.31.6-1.41.61.5-1.21.3-0.91.6-2.20.2
Delay discount exponential model param0.40.41.3-0.11.01.0-0.41.20.20.80.20.50.4-0.40.2-1.00.6-0.8-0.6
Extinction: sum of active levers before priming0.20.20.7-0.10.1-0.0-0.9-0.30.80.4-0.5-0.20.20.20.5-0.30.6-0.5-0.4
Active lever presses in extinction session 64.13.97.4-2.71.31.4-2.21.52.61.7-2.52.02.2-1.82.5-1.71.7-1.21.9
Bone: final force0.20.31.3-0.60.60.3-1.10.10.80.5-0.5-0.10.40.20.6-0.10.5-0.0-0.5
Bone: final moment0.10.21.0-0.50.60.4-1.00.10.70.5-0.5-0.10.30.20.50.00.4-0.1-0.5
Food consumed during 24 hour testing period0.20.21.00.50.3-0.2-0.0-0.2-0.3-0.10.5-0.5-0.30.5-0.60.2-0.6-0.1-1.0
Glucose0.10.10.50.10.40.4-0.10.40.30.40.20.10.2-0.40.1-0.30.7-0.2-0.7
Heart weight0.71.03.51.00.3-0.20.3-0.5-1.1-0.41.1-1.2-1.01.1-1.51.5-0.9-0.1-1.9
Delay discount hyperbolic model param0.30.31.0-0.00.90.8-0.31.00.20.70.20.30.4-0.30.1-0.90.5-0.6-0.8
Intermittent access intake day 1-15 change3.73.79.1-2.13.02.3-1.92.12.02.0-1.82.02.0-2.01.5-2.01.2-1.2-0.4
Intermittent access intake escalation2.92.98.3-1.92.92.1-1.62.01.71.7-1.41.81.8-1.71.1-1.70.8-0.9-0.8
Intermittent access intake escalation 24.24.110.5-2.33.22.4-1.92.42.02.1-1.72.42.2-2.21.4-2.11.0-1.5-0.4
Intermitt. access day 1 inactive lever presses0.20.20.5-0.30.60.6-0.40.30.20.5-0.30.50.3-0.40.2-0.30.2-0.70.4
Intermitt. access day 15 inactive lever presses0.60.71.5-0.71.21.1-1.10.60.80.9-0.70.80.7-0.60.7-0.60.8-1.00.9
Intermitt. access escalation Index1.00.81.8-0.60.71.1-0.31.30.51.0-0.51.30.9-1.30.6-0.51.4-1.10.3
Intermittent access day 1 total infusions0.70.81.5-0.60.80.9-1.01.00.81.1-0.50.81.0-0.81.1-1.01.2-0.90.4
Intermittent access day 15 total infusions2.93.37.6-1.72.82.3-1.82.51.62.1-0.91.71.9-1.71.4-1.91.6-1.1-0.9
Intermittent access terminal intake (last 3 days)2.83.06.9-1.82.62.1-1.82.21.41.9-0.91.81.9-1.81.3-1.81.4-1.2-0.2
Intermittent access total infusions1.82.03.8-1.21.81.7-1.52.01.11.6-0.61.41.5-1.41.3-1.61.5-1.00.0
Intermittent access day 1 locomotion0.10.10.60.10.30.4-0.40.4-0.10.50.30.00.3-0.00.3-0.30.7-0.8-0.3
Intermittent access day 15 total locomotion0.10.20.70.40.3-0.10.0-0.4-0.2-0.20.6-0.6-0.20.5-0.2-0.1-0.40.8-0.4
Intermittent access total locomotion0.00.00.10.0-0.0-0.2-0.3-0.20.00.00.2-0.20.10.20.2-0.40.10.10.3
Intermittent access standard deviation3.53.79.6-1.93.12.2-2.02.21.82.2-1.32.02.1-1.81.3-1.71.4-1.8-0.9
Left kidney weight0.20.42.40.4-0.3-0.20.10.1-0.3-0.31.0-0.9-0.40.9-0.40.60.10.8-1.6
Right kidney weight0.92.65.61.6-1.3-1.41.1-1.2-1.3-1.31.9-2.2-1.52.0-1.41.8-0.91.7-2.4
Cocaine induced anxiety0.30.30.9-0.6-0.00.3-0.00.60.30.3-0.51.00.7-0.90.6-0.40.7-0.80.7
Post-drug Anxiety0.80.92.70.8-1.7-0.81.2-0.9-1.0-1.20.8-0.6-1.00.7-0.50.9-0.41.01.3
Baseline Anxiety1.01.01.81.0-1.2-0.80.8-1.3-0.8-1.00.9-1.3-1.31.3-0.81.2-0.70.90.3
Tail length0.30.92.4-0.50.70.5-1.50.31.31.1-1.00.30.8-0.41.0-0.01.4-1.4-1.1
Length with tail0.10.31.6-0.2-0.2-0.3-0.6-0.40.90.1-0.1-0.60.30.70.60.60.90.2-1.3
Length without tail0.20.51.6-0.0-0.8-0.80.2-0.60.4-0.40.5-0.8-0.01.00.40.40.61.3-1.0
Times rat made contact with spout0.60.72.1-0.90.10.3-1.00.20.70.5-1.30.80.7-1.00.8-0.50.7-1.41.3
Lifetime Intake0.91.02.1-0.81.31.3-1.11.40.71.2-0.20.91.1-0.91.0-1.21.0-0.50.2
Liver weight, left0.30.42.1-0.2-0.20.3-0.50.40.80.5-0.4-0.10.50.01.0-0.31.50.2-1.3
Liver weight, right0.10.21.70.1-0.7-0.2-0.1-0.10.50.10.1-0.30.10.30.50.21.3-0.2-0.7
Locomotor activity0.20.31.2-0.30.70.4-0.40.20.40.4-1.10.70.5-0.80.3-0.3-0.3-0.1-0.2
Locomotor testing distance0.30.41.8-0.61.10.4-0.60.30.60.5-1.30.80.6-0.90.2-0.3-0.4-0.5-0.4
Locomotor testing rearing1.21.84.3-1.41.30.9-1.50.91.71.2-2.11.51.5-1.61.5-1.50.9-0.80.4
Locomotion in novel chamber3.54.36.6-2.62.12.2-2.32.32.32.0-2.22.02.1-2.12.1-2.41.3-0.91.5
Locomotion in novel chamber post-restriction0.20.20.7-0.6-0.3-0.5-0.7-0.30.6-0.1-0.1-0.50.30.40.6-0.60.20.80.2
Fecal boli incidents, locomotor time 11.31.42.3-1.40.60.8-1.40.91.11.1-1.51.21.2-1.31.3-1.31.2-1.11.5
Change in fecal boli incidents, locomotor task1.31.22.31.0-0.8-1.11.0-1.1-0.9-1.11.4-1.1-1.01.1-1.00.8-1.11.5-1.1
Time >=10cm from walls, locomotor time 10.70.75.9-0.20.7-0.1-0.50.30.80.7-0.00.00.70.00.4-0.51.3-0.5-2.4
Bouts of movement, locomotor time 10.20.21.4-0.6-0.20.1-0.20.10.5-0.1-1.00.10.2-0.30.6-0.20.01.20.6
Total resting periods, locomotor time 10.20.31.6-0.7-0.3-0.2-0.3-0.20.4-0.3-0.9-0.10.2-0.20.6-0.1-0.01.30.6
Rest time, locomotor task time 11.11.23.9-1.90.40.4-1.30.30.80.4-1.90.80.8-1.21.0-0.80.4-0.12.0
Distance moved, locomotor task time 11.01.14.31.7-0.6-0.80.9-0.7-0.7-0.41.6-1.0-0.81.2-0.90.9-0.2-0.1-2.1
Vertical activity count, locomotor time 11.21.35.61.2-0.2-0.61.1-0.4-0.9-0.61.9-0.9-0.81.2-1.21.2-0.80.4-2.4
Time >=10cm from walls, locomotor time 20.50.51.4-0.50.5-0.0-0.30.30.80.6-0.80.70.9-0.70.5-0.71.0-1.1-1.2
Bouts of movement, locomotor time 21.41.53.40.8-1.4-1.80.9-1.8-1.0-1.60.0-0.9-1.11.0-1.11.2-1.71.20.3
Total resting periods, locomotor time 21.21.33.50.5-1.3-1.90.7-1.8-0.8-1.6-0.3-0.8-0.90.9-1.01.1-1.61.20.3
Rest time, locomotor task time 20.40.52.1-0.7-0.9-0.9-0.2-0.80.1-0.8-0.8-0.5-0.10.40.30.4-0.41.50.5
Distance moved, locomotor task time 20.50.62.60.30.80.7-0.30.80.61.10.30.60.5-0.40.3-0.51.2-1.6-1.1
Vertical activity count, locomotor time 20.30.42.20.21.00.50.10.4-0.10.60.40.50.2-0.3-0.40.20.2-1.5-1.0
Light reinforcement 10.10.20.8-0.1-0.5-0.10.2-0.2-0.1-0.40.3-0.3-0.30.40.10.1-0.40.90.8
Light reinforcement 20.91.32.20.6-1.3-1.01.2-1.1-1.3-1.31.3-0.9-1.20.9-1.11.0-1.50.81.3
Bone: marrow area5.912.818.1-3.94.03.9-4.33.24.13.9-3.83.43.6-3.33.6-3.23.6-3.11.4
Bone: maximum diameter6.612.217.1-3.93.73.9-3.93.64.13.7-3.53.43.6-3.33.7-3.13.4-2.51.3
Bone: maximum force1.01.84.1-1.71.61.4-2.01.11.71.4-1.40.91.3-0.81.4-1.11.2-0.60.5
Bone: maximum moment0.91.63.5-1.51.61.6-1.91.11.61.4-1.30.91.2-0.81.3-0.91.1-0.70.5
Mean time between licks in bursts0.40.61.91.10.0-0.31.1-0.4-0.8-0.60.6-0.5-0.90.4-1.30.4-0.80.0-1.4
Mean num. licks in bursts2.22.74.6-1.41.61.9-1.71.81.61.8-1.41.71.5-1.81.4-1.62.2-1.60.2
Cd content in liver1.71.93.41.7-0.8-0.81.7-0.8-1.4-1.21.5-1.5-1.41.5-1.61.1-1.41.1-1.8
Co content in liver0.70.82.41.2-0.4-0.11.5-0.4-1.2-0.71.1-0.6-1.10.7-1.20.9-1.20.2-0.6
Cu content in liver4.65.69.31.9-2.1-2.52.5-3.0-2.5-2.71.8-2.3-2.52.3-2.42.6-2.82.20.0
Fe content in liver2.53.04.81.7-1.5-1.82.1-1.6-2.1-1.91.5-1.5-1.71.4-2.02.0-2.21.5-0.8
K content in liver0.20.20.9-0.1-0.9-0.90.2-0.8-0.1-0.6-0.3-0.0-0.10.10.1-0.1-0.10.80.4
Mg content in liver0.90.92.10.6-1.2-1.50.8-1.4-0.8-1.20.2-0.8-0.80.7-0.70.7-1.01.2-0.3
Mn content in liver2.32.64.40.9-1.9-2.11.5-1.8-1.7-2.01.6-1.6-1.51.6-1.41.0-2.01.90.2
Na content in liver1.51.64.01.0-2.0-1.91.3-1.4-1.3-1.61.1-1.2-1.11.1-0.90.5-1.11.30.3
Rb content in liver0.20.20.6-0.60.20.1-0.50.00.60.4-0.70.40.5-0.30.6-0.40.8-0.3-0.1
Se content in liver19.223.533.14.6-4.7-5.55.2-5.6-5.4-5.54.4-4.7-5.14.5-5.24.5-5.83.8-1.5
Sr content in liver0.10.10.60.00.80.40.00.2-0.10.10.50.0-0.10.2-0.50.2-0.30.1-0.4
Zn content in liver2.32.53.81.9-1.6-1.91.8-1.9-1.9-1.61.1-1.3-1.61.3-1.81.8-1.70.2-0.4
Bone: minimum diameter7.514.018.2-3.74.24.2-4.24.04.34.3-3.63.53.9-3.43.8-3.54.1-3.20.5
Time in familiar zone, hab. session 10.30.21.5-0.50.50.8-0.20.70.20.4-0.00.50.3-0.10.3-0.3-0.2-0.21.2
Time in novel zone, hab. session 10.20.20.80.6-0.5-0.90.3-0.9-0.3-0.50.2-0.3-0.30.3-0.40.3-0.1-0.0-0.6
Total zone transitions, hab. session 10.10.10.7-0.2-0.0-0.1-0.2-0.20.3-0.1-0.20.20.10.20.3-0.4-0.10.80.2
Total locomotion distance, hab. session 10.91.22.91.0-1.5-1.40.9-1.5-0.9-1.30.6-1.0-1.01.2-0.60.8-1.21.7-0.2
Locomotion velocity, hab. session 11.82.54.71.5-2.1-2.01.5-2.0-1.3-1.81.2-1.5-1.51.6-1.01.4-1.52.2-0.6
Time in familiar zone, hab. session 20.20.20.40.7-0.20.10.6-0.2-0.4-0.30.4-0.2-0.60.3-0.60.5-0.50.0-0.2
Time in novel zone, hab. session 20.00.00.0-0.10.1-0.2-0.1-0.1-0.1-0.00.1-0.10.1-0.1-0.0-0.10.00.10.1
Total zone transitions, hab. session 20.81.02.51.0-0.8-1.00.8-1.1-0.7-1.10.9-1.1-1.11.1-0.90.9-1.21.6-0.7
Total locomotion distance, hab. session 21.01.32.81.3-1.2-1.10.9-1.2-0.9-1.10.9-1.3-1.21.2-0.81.3-1.21.7-0.6
Locomotion velocity, hab. session 21.11.53.51.2-1.5-1.30.9-1.4-0.9-1.21.0-1.4-1.21.3-0.71.4-1.31.9-0.6
Novel to familiar place preference ratio4.44.58.7-2.92.01.5-2.71.62.01.8-2.52.12.3-2.32.0-2.11.3-2.12.0
Novelty place preference4.84.99.0-3.02.11.6-2.81.62.11.9-2.62.22.4-2.42.0-2.11.4-2.12.1
Time in novel zone, NPP test4.84.98.6-2.92.21.6-2.81.72.12.0-2.62.32.4-2.52.0-2.21.4-2.32.0
Total zone transitions, NPP test1.01.42.31.4-1.4-1.40.9-1.5-0.7-1.11.0-1.3-1.21.4-0.81.1-0.81.3-1.1
Total locomotion distance, NPP test2.02.74.51.6-2.0-2.11.3-2.1-1.4-1.71.3-1.8-1.61.8-1.21.9-1.61.8-0.6
Locomotion velocity, NPP test1.92.64.51.6-2.0-2.11.2-2.1-1.3-1.71.3-1.8-1.51.8-1.21.8-1.41.7-0.7
Intraocular pressure0.20.20.60.2-0.4-0.10.1-0.2-0.6-0.40.3-0.6-0.40.6-0.20.6-0.70.70.8
Delta distance traveled before/after self-admin1.61.84.4-1.61.11.5-1.41.21.11.3-1.11.31.2-1.21.4-0.81.2-1.32.1
Delta ambulatory time before/after self-admin2.83.04.6-2.01.41.9-1.91.71.61.7-1.51.71.7-1.71.8-1.31.8-1.72.2
Parametrial fat weight0.20.41.30.8-0.6-0.10.90.0-0.5-0.21.0-0.7-0.51.0-0.40.30.50.3-1.2
Pavlov. Cond. lever latency0.10.10.40.10.40.50.40.3-0.3-0.10.3-0.1-0.30.2-0.40.3-0.50.60.5
Pavlov. Cond. magazine entry latency1.01.36.31.2-0.5-1.20.8-1.1-1.0-0.81.0-1.1-0.91.1-1.21.2-1.10.3-2.5
Pavlov. Cond. change in total contacts0.40.43.80.50.4-0.20.20.0-0.50.10.6-0.2-0.10.3-0.70.3-0.5-0.7-2.0
Pavlov. Cond. index score0.40.63.10.7-0.7-1.20.4-0.9-0.5-0.50.6-0.7-0.30.7-0.40.6-0.40.1-1.8
Pavlov. Cond. latency score0.30.42.50.6-0.8-1.10.2-0.9-0.3-0.40.4-0.6-0.20.5-0.20.4-0.10.0-1.6
Pavlov. Cond. lever contacts0.50.61.80.9-1.2-1.30.5-1.2-0.5-0.70.6-0.9-0.50.8-0.30.7-0.10.4-1.2
Pavlov. Cond. magazine entry number0.30.44.0-0.6-0.20.2-0.30.20.50.0-0.60.40.3-0.40.6-0.50.50.32.0
Pavlov. Cond. intertrial magazine entries0.00.00.20.0-0.4-0.1-0.10.00.2-0.1-0.2-0.10.10.20.40.00.40.10.4
Pavlov. Cond. lever-magazine prob. diff.0.50.73.30.8-0.8-1.20.6-0.9-0.7-0.60.7-0.7-0.40.7-0.60.7-0.50.1-1.8
Pavlov. Cond. response bias0.60.75.30.9-0.2-0.80.5-0.8-0.7-0.40.7-0.7-0.50.7-0.80.7-0.8-0.0-2.3
Pavlov. Cond. lever latency1.31.83.1-1.41.01.3-1.21.71.41.3-1.21.71.4-1.81.3-1.21.2-1.11.0
Pavlov. Cond. magazine entry latency0.20.22.10.50.2-0.30.2-0.3-0.40.1-0.1-0.3-0.10.3-0.40.2-0.2-0.7-1.4
Pavlov. Cond. change in total contacts0.40.61.20.9-0.9-1.00.6-1.1-0.8-0.70.6-1.0-0.71.1-0.50.4-0.30.1-0.8
Pavlov. Cond. index score0.60.71.50.8-0.6-0.90.6-1.1-0.9-0.70.6-1.1-0.71.2-0.70.8-0.50.1-1.2
Pavlov. Cond. latency score0.40.51.30.6-0.4-0.80.4-0.9-0.7-0.50.5-0.9-0.51.0-0.50.7-0.40.0-1.1
Pavlov. Cond. lever contacts1.11.52.81.2-1.1-1.21.0-1.7-1.2-1.20.9-1.6-1.21.6-1.01.2-0.91.0-0.8
Pavlov. Cond. magazine entry number1.72.14.2-1.81.21.7-1.41.71.61.2-1.21.61.3-1.61.4-1.51.0-0.62.1
Pavlov. Cond. intertrial magazine entries1.11.52.1-1.10.61.1-1.11.41.41.1-1.31.31.3-1.41.5-1.21.3-0.81.1
Pavlov. Cond. lever-magazine prob. diff.0.40.51.40.7-0.5-0.90.5-1.1-0.8-0.60.4-0.9-0.51.0-0.60.7-0.5-0.1-1.2
Pavlov. Cond. response bias1.11.53.01.3-1.0-1.41.0-1.7-1.3-1.10.8-1.5-1.11.5-1.01.2-0.90.5-1.4
Time in closed arm before self-admin1.92.23.4-1.81.31.1-1.71.21.41.3-1.81.81.5-1.71.3-1.50.8-1.41.5
Time in closed arm after self-admin0.20.20.60.0-0.8-0.6-0.4-0.60.6-0.1-0.7-0.2-0.00.10.4-0.00.10.30.1
Time in open arm before self-admin0.30.31.10.8-0.6-0.11.0-0.2-0.6-0.50.5-0.5-0.70.5-0.40.6-0.40.5-0.3
Time in open arm after self-admin0.10.10.5-0.70.50.30.00.20.40.0-0.40.50.4-0.40.2-0.2-0.20.00.4
Bone: periosteal estimation3.98.012.9-3.13.03.1-3.62.53.53.1-3.02.52.9-2.43.1-2.33.0-2.10.9
Bone: periosteal perimeter4.16.99.8-2.82.62.8-3.12.63.12.9-2.82.42.7-2.33.0-2.12.8-2.01.0
Bone: post-yield work1.41.93.7-1.51.81.6-1.91.61.61.6-1.30.91.5-0.91.5-0.91.2-0.90.3
Progressive ratio test 1 active lever presses0.91.01.9-0.90.91.1-0.91.10.81.0-0.70.91.0-1.01.1-1.41.1-0.71.1
Progressive ratio test 1 breakpoint1.01.01.8-1.00.91.1-1.01.10.81.0-0.71.01.0-1.11.0-1.31.1-0.81.1
Progressive ratio test 1 inactive lever presses3.53.94.6-1.92.02.1-2.11.92.12.1-1.82.02.0-1.82.1-1.92.0-2.01.5
Progressive ratio test 2 active lever presses2.83.04.9-1.92.22.0-1.71.91.91.8-1.51.71.9-1.71.9-1.91.5-0.70.6
Progressive ratio test 2 breakpoint3.64.15.9-2.22.42.3-2.12.12.22.1-1.92.02.2-2.02.2-2.21.9-0.91.0
Progressive ratio test 2 inactive lever presses2.22.64.1-1.82.01.8-1.61.81.51.6-1.31.71.8-1.61.7-1.81.1-0.61.3
Incentive Sensitization - Responses4.64.78.3-2.52.92.5-2.12.42.22.3-2.22.42.4-2.22.1-2.01.7-1.10.5
Incentive Sensitization - Breakpoint4.14.27.6-2.42.82.4-2.12.32.12.2-2.12.22.2-2.02.0-1.81.6-1.00.4
Sum of active levers in priming session hrs 5-60.10.10.3-0.10.40.30.00.0-0.20.1-0.00.1-0.10.1-0.20.5-0.5-0.20.0
Progressive ratio0.20.20.90.8-0.9-0.00.80.2-0.2-0.20.1-0.5-0.30.40.30.20.50.3-0.7
Food seeking constrained by brief footshock0.40.54.2-0.10.90.1-0.80.10.90.5-0.8-0.20.60.20.6-0.10.20.7-2.0
Seeking ratio, punishment vs. effort0.30.31.2-0.61.1-0.2-1.0-0.50.80.3-0.80.10.4-0.00.00.1-0.4-0.0-0.8
Retroperitoneal fat weight0.10.20.60.6-0.60.40.30.30.10.20.5-0.2-0.30.80.20.60.8-0.0-0.1
Reaction time number correct2.23.25.8-2.41.41.8-1.71.91.91.6-2.22.11.9-1.72.0-1.61.7-1.10.9
Reaction time mean minus median0.40.63.70.21.51.00.01.0-0.10.70.40.30.2-0.3-0.40.1-0.2-0.2-1.9
Reaction time mean minus median AUC0.40.53.20.41.10.80.50.8-0.40.30.50.2-0.1-0.3-0.60.3-0.50.2-1.8
Reaction time num false alarms0.20.31.00.4-0.9-0.6-0.2-0.60.4-0.20.1-0.5-0.11.00.40.50.70.3-0.5
Reaction time num false alarms AUC0.20.31.20.5-0.7-0.6-0.2-0.60.3-0.20.0-0.5-0.21.10.20.70.50.2-0.8
Reaction time trials correct on left2.23.25.8-2.41.41.8-1.71.91.91.6-2.22.11.9-1.72.0-1.61.7-1.10.9
Reaction time trials on left2.13.05.5-2.31.31.8-1.61.91.91.6-2.12.01.9-1.62.0-1.61.7-1.10.7
Reaction time mean1.01.44.01.9-0.2-0.81.1-0.9-1.3-0.61.4-1.1-1.20.8-1.61.1-1.10.3-2.0
Reaction time mean AUC1.52.14.62.2-0.5-1.11.4-1.2-1.7-0.91.7-1.3-1.51.1-1.91.4-1.40.6-2.0
Median of all reaction times1.11.54.12.0-0.7-1.11.2-1.3-1.4-0.91.3-1.2-1.40.9-1.71.1-1.10.3-1.5
Reaction time omissions0.70.95.30.21.31.2-0.11.40.21.1-0.20.60.6-0.50.1-0.00.6-1.1-2.3
Reaction time false alarm rate0.91.33.01.5-1.4-1.40.6-1.4-0.5-0.91.0-1.5-1.01.7-0.61.3-0.30.9-1.0
Reaction time premature initiation rate0.60.73.20.9-0.8-0.80.7-0.7-0.6-0.61.2-1.0-0.61.0-0.50.60.00.8-1.8
Reaction time premature initiations0.20.31.9-0.40.10.3-0.20.50.50.30.00.20.40.10.6-0.31.00.2-1.4
Std. dev. reaction times0.71.07.61.30.90.30.80.2-0.90.11.1-0.4-0.60.4-1.21.0-0.70.0-2.8
Reaction time trials completed2.13.05.5-2.31.31.8-1.61.91.91.6-2.12.01.9-1.62.0-1.61.7-1.10.7
Reaction time trials AUC1.92.75.0-2.21.21.6-1.51.71.71.5-2.11.91.7-1.51.9-1.51.6-1.20.8
Run reversals in cocaine runway, females0.10.10.6-0.1-0.1-0.2-0.1-0.5-0.2-0.3-0.2-0.1-0.20.4-0.20.5-0.80.10.7
Run reversals in cocaine runway, males2.92.94.31.7-1.5-1.81.6-1.6-1.9-1.72.0-1.9-1.61.9-1.51.3-1.42.1-0.9
Latency to leave start box in cocaine runway2.32.44.0-1.01.42.0-1.42.01.71.8-1.51.71.4-1.81.5-1.81.5-1.40.8
Latency to leave start box in cocaine runway, F3.63.95.1-1.51.92.2-2.02.32.12.2-2.12.11.9-2.21.8-2.21.8-1.71.2
Latency to leave start box in cocaine runway, M0.10.10.30.10.20.60.10.60.20.3-0.10.20.1-0.20.20.00.2-0.2-0.6
Std. dev. time between licks in bursts2.83.35.52.3-1.8-1.42.3-1.6-2.0-1.81.9-1.9-2.11.7-2.01.8-1.71.3-1.0
Total sessions with >9 infusions0.10.10.40.00.1-0.1-0.4-0.3-0.0-0.00.3-0.4-0.10.30.2-0.0-0.20.40.7
Short access day 1 total inactive lever presses2.32.68.5-1.51.62.2-1.32.10.91.4-0.51.81.4-1.81.3-1.80.8-0.72.9
Short access day 10 total inactive lever presses0.10.10.60.1-0.3-0.00.3-0.1-0.1-0.2-0.20.4-0.1-0.4-0.20.10.2-0.70.8
Short access day 1 total infusions0.30.31.50.4-0.5-0.20.5-0.2-0.7-0.41.2-0.5-0.40.5-0.20.2-0.50.90.7
Short access day 10 total infusions0.20.31.11.0-0.1-0.10.3-0.1-0.7-0.11.0-0.5-0.40.6-0.40.4-0.10.1-0.5
Short access total infusions0.10.10.4-0.10.40.4-0.50.40.20.40.20.10.4-0.10.6-0.50.40.20.6
Short access day 1 locomotion0.10.11.3-0.3-0.20.1-0.10.00.10.0-0.00.10.1-0.10.3-0.30.10.01.1
Short access day 10 total locomotion0.10.10.40.0-0.1-0.1-0.10.0-0.60.00.6-0.2-0.10.3-0.20.2-0.2-0.30.0
Short access total locomotion0.20.20.60.4-0.5-0.50.3-0.6-0.5-0.40.3-0.3-0.40.3-0.30.3-0.3-0.10.8
One hour access (0.3 mA shock)6.88.012.7-3.43.63.1-3.23.22.83.0-2.42.83.1-2.82.8-2.92.5-1.60.5
Compulsive drug intake3.03.05.5-1.51.71.8-1.52.01.61.9-1.91.91.7-1.81.3-1.52.3-2.30.0
One hour access (shock baseline)0.91.12.5-1.31.61.2-1.41.20.91.1-0.60.91.2-0.91.1-1.00.6-0.2-0.1
Social response proportion2.52.74.2-1.91.71.8-1.31.81.31.6-1.51.81.6-2.01.4-1.81.1-1.51.8
Social responses0.60.81.8-0.91.11.2-0.70.90.70.9-0.40.80.7-1.00.8-1.10.7-0.41.4
Social time0.60.81.41.0-1.0-1.11.0-1.2-1.0-1.00.9-1.0-0.90.9-0.80.8-0.60.6-0.3
Soleus weight1.33.75.2-2.02.02.3-2.21.72.22.1-1.81.91.7-1.91.9-2.12.1-1.31.1
Bone: stiffness1.42.24.8-1.71.11.2-2.21.32.11.6-1.31.11.6-1.01.8-1.12.1-0.90.2
Tibialis anterior weight0.93.28.0-1.70.30.8-2.11.12.11.6-2.01.61.9-1.72.4-1.82.8-1.51.5
Time to tail flick, vehicle, before self-admin0.60.63.60.2-0.8-0.50.6-0.7-0.9-0.80.6-0.3-0.70.4-0.50.5-0.80.61.9
Time to tail flick, vehicle, after self-admin1.11.23.3-1.00.00.2-1.30.21.70.9-1.80.81.1-0.61.6-0.71.6-1.00.4
Time to tail flick, test, before self-admin3.33.36.1-1.91.51.3-2.51.22.21.9-2.11.61.9-1.62.0-1.81.9-1.81.2
Time to tail flick, test, after self-admin1.41.53.9-1.10.70.9-0.80.61.10.9-1.81.51.1-1.31.0-0.71.1-2.01.7
Delta time to tail flick, vehicle, before/after SA2.72.75.7-1.50.80.9-1.91.12.41.7-2.21.31.9-1.12.3-1.32.2-1.4-0.6
Delta time to tail flick, test, before/after SA0.10.10.3-0.1-0.10.20.30.0-0.1-0.1-0.30.40.0-0.20.10.10.1-0.30.5
Tibia length0.10.21.20.3-0.1-0.40.3-0.6-0.2-0.40.3-0.6-0.40.6-0.4-0.0-0.30.5-1.1
Ambulatory time before self-admin0.50.51.9-0.60.90.3-0.50.30.90.6-1.41.00.8-0.80.4-0.80.3-1.0-0.0
Ambulatory time after self-admin6.16.78.9-3.02.72.2-2.92.12.82.5-2.92.92.7-2.72.3-2.21.7-2.82.6
Bone: tissue strength0.10.10.20.10.50.5-0.20.2-0.00.3-0.2-0.0-0.1-0.1-0.2-0.40.3-0.3-0.3
Total heroin consumption0.10.10.20.0-0.3-0.3-0.2-0.40.2-0.1-0.0-0.4-0.10.50.3-0.10.20.50.0
Bone: trabecular number4.16.410.1-3.03.22.9-2.72.72.52.5-2.62.52.6-2.62.3-2.91.6-1.91.7
Bone: trabecular spacing2.22.94.72.2-1.9-1.82.0-1.5-1.8-1.51.9-1.7-1.61.7-1.71.9-1.00.6-1.9
Bone: trabecular thickness3.23.85.4-2.12.22.3-2.12.12.22.0-2.21.91.9-1.91.9-2.21.6-1.11.0
Bone: trabecular tissue density0.71.01.8-1.20.60.9-1.00.91.30.9-0.91.01.0-1.01.2-1.11.2-0.50.8
Water consumed over 24 hours1.31.63.6-1.00.70.6-1.50.71.21.2-1.71.31.3-1.51.2-1.31.0-1.91.2
Number of responses in last shaping day0.40.41.8-0.40.41.10.01.3-0.10.30.70.50.3-0.50.5-0.60.50.41.3