Hub : Genes

Mtus2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Mtus2	0.06	0.04	2.6e-06	0.05	0.04	0.02	0.04	4.4e-06	3.5e-05	4.5e-03	8.2e-06
2	Brain	alternative TSS	XM_017598434.2	0.03	0.02	1.5e-03	0.03	0.02	0.03	0.03	6.5e-04	2.2e-03	9.6e-04	4.8e-04
3	Brain	gene expression	Mtus2	0.26	0.1	2.0e-11	0.12	0.13	0.14	0.13	1.3e-11	9.2e-12	7.1e-13	2.6e-12
4	Brain	alternative TSS	XM_017598434.2	0.02	0.02	5.6e-03	0.02	0.02	0.02	0.02	3.5e-03	5.6e-03	1.2e-02	5.6e-03
5	Brain	isoform ratio	XM_017598434.2	0.02	0.02	2.0e-03	0.03	0.03	0.03	0.03	6.7e-04	1.3e-03	1.5e-03	1.4e-03
6	PL	gene expression	Mtus2	0.04	0.03	2.7e-05	0.02	0.04	0.03	0.03	2.1e-03	3.6e-05	2.4e-04	3.5e-04
7	Eye	isoform ratio	XM_017598434.2	0.33	0.22	6.4e-03	0.05	0.03	-0.01	0.02	5.4e-02	1.0e-01	4.8e-01	1.6e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bone: apparent density	1.8	3.1	3.6	1.6	1.9	-1.7	-1.9	-1.9	1.7	1.7
Area under the delay curve	0.8	0.9	2.8	-0.5	-0.6	0.4	0.7	0.7	-1.3	-1.7
BMI with tail	0.7	2.4	3.3	1.4	1.6	-1.2	-1.7	-1.7	1.1	1.8
BMI without tail	0.5	0.9	2.5	-1.1	-0.7	0.9	0.6	0.6	-1.6	-0.9
Body weight	1.5	6.4	8.5	-2.9	-2.5	2.8	2.4	2.4	-2.5	-2.1
Weight adjusted by age	1.3	1.5	2.5	-0.9	-1.4	1.6	1.5	1.5	-0.2	0.5
Bone surface	0.6	1.1	1.5	0.7	1.2	-1.2	-1.2	-1.2	0.8	1.0
Bone volume	1.5	2.6	3.4	1.1	1.7	-1.5	-1.7	-1.7	1.4	1.8
Breakpoint value in progressive ratio session	0.2	0.2	0.4	-0.7	-0.5	0.5	0.4	0.4	-0.5	-0.3
Number of licking bursts	0.9	1.1	1.9	-1.4	-1.1	1.0	1.0	1.0	-0.9	-0.8
Context. condit. distance diff. score	0.2	0.3	0.6	-0.8	-0.4	0.3	0.3	0.3	-0.6	-0.7
Locomotion velocity, session 1	1.6	1.7	3.0	-1.3	-1.3	1.0	1.2	1.2	-1.1	-1.7
Locomotion distance, session 1	0.1	0.1	0.3	0.0	-0.1	0.1	0.2	0.2	0.2	-0.6
Locomotion velocity, session 2	0.3	0.3	1.8	-0.4	-0.3	0.1	0.3	0.3	-0.2	-1.3
Locomotion distance, session 2	0.6	0.8	1.5	-1.0	-0.9	0.8	0.9	0.9	-0.6	-1.2
Locomotion velocity, session 3	1.0	1.2	2.2	-1.1	-1.3	1.5	1.3	1.3	-0.6	-0.3
Locomotion distance, session 3	1.8	1.9	3.1	-1.0	-1.6	1.8	1.6	1.6	-1.0	-0.9
Stereotopy head waving bouts, day 3	0.2	0.2	0.4	0.0	0.5	-0.6	-0.6	-0.6	-0.3	-0.6
Stereotopy head waving duration, day 3	0.5	0.6	1.1	0.3	0.9	-0.9	-1.0	-1.0	0.3	0.4
Locomotion velocity, session 7	0.2	0.2	0.8	-0.6	-0.0	-0.1	-0.1	-0.1	-0.9	-0.4
Locomotion distance, session 7	0.3	0.3	0.7	-0.0	0.6	-0.8	-0.7	-0.7	-0.1	-0.3
Stereotopy head waving bouts, day 7	2.1	2.4	2.9	-1.6	-1.6	1.7	1.6	1.6	-1.5	-1.1
Stereotopy head waving duration, day 7	1.6	1.9	2.7	-1.3	-1.5	1.6	1.5	1.5	-1.4	-0.8
Locomotion velocity, session 8	1.6	2.0	2.1	-1.4	-1.5	1.3	1.5	1.5	-1.4	-1.3
Locomotion distance, session 8	0.4	0.6	1.6	-1.0	-0.7	0.6	0.6	0.6	-0.5	-1.3
Degree of sensitization distance	2.3	2.3	4.7	0.9	1.8	-2.2	-1.9	-1.9	0.7	0.1
Degree of sensitization stereotypy	1.1	1.2	2.3	-1.0	-1.2	1.5	1.2	1.2	-0.8	-0.0
Conditioned locomotion	1.6	1.9	3.2	1.4	1.6	-1.8	-1.6	-1.6	1.0	-0.0
Cocaine response after cond. corrected	0.7	0.8	1.1	0.7	1.0	-0.8	-1.0	-1.0	0.8	0.5
Cocaine response after cond. not corrected	0.6	0.7	1.1	0.5	0.9	-0.9	-1.0	-1.0	0.6	0.3
Cocaine response before conditioning	1.2	1.4	2.3	-1.4	-1.1	0.7	1.1	1.1	-1.5	-1.3
Saline control response	2.7	3.5	4.5	-1.5	-2.0	1.9	2.1	2.1	-1.7	-1.6
Bone: connectivity density	0.7	1.1	1.6	0.9	1.2	-1.3	-1.2	-1.2	0.8	0.3
Bone: cortical apparent density	3.3	4.3	5.1	2.3	2.1	-1.8	-2.1	-2.1	2.1	2.1
Bone: cortical area	0.3	0.5	1.5	-1.1	-0.4	0.5	0.2	0.2	-1.2	-0.3
Bone: cortical porosity	0.9	1.0	1.3	-1.1	-1.0	1.0	1.0	1.0	-0.8	-1.0
Bone: cortical porosity	1.2	1.3	1.4	-1.2	-1.2	1.1	1.1	1.1	-1.0	-1.1
Bone: cortical thickness	0.5	0.8	1.6	0.2	1.1	-0.9	-1.2	-1.2	0.2	0.8
Bone: cortical thickness	0.1	0.1	0.2	0.5	0.4	-0.5	-0.3	-0.3	0.3	-0.3
Bone: cortical tissue density	3.8	5.0	6.0	2.4	2.2	-2.0	-2.2	-2.2	2.4	2.2
Condit. Reinf. active minus inactive responses	0.5	0.6	0.9	1.0	0.9	-0.8	-0.8	-0.8	0.5	0.4
Condit. Reinf. active-inactive response ratio	4.0	4.3	5.6	2.4	2.2	-2.0	-2.1	-2.1	2.0	1.8
Condit. Reinf. active responses	0.1	0.1	0.2	0.5	0.3	-0.3	-0.3	-0.3	0.3	0.1
Condit. Reinf. inactive responses	1.6	1.9	2.2	-1.5	-1.4	1.4	1.4	1.4	-1.3	-1.2
Incentive salience index mean	0.2	0.2	0.4	-0.5	-0.4	0.4	0.4	0.4	-0.6	-0.6
Condit. Reinf. lever presses	0.4	0.5	1.2	-1.1	-0.7	0.6	0.6	0.6	-0.7	-0.4
Condit. Reinf. active minus inactive responses	1.4	1.7	2.1	-1.1	-1.3	1.0	1.4	1.4	-1.5	-1.4
Condit. Reinf. active-inactive response ratio	2.4	2.5	2.9	-1.6	-1.7	1.4	1.7	1.7	-1.6	-1.3
Condit. Reinf. active responses	2.4	3.3	3.9	-1.5	-1.9	1.5	2.0	2.0	-1.9	-1.9
Condit. Reinf. inactive responses	1.3	1.6	1.9	-0.9	-1.3	1.2	1.4	1.4	-1.3	-1.2
Condit. Reinf. lever presses	1.1	1.5	2.5	-1.2	-1.2	0.9	1.2	1.2	-1.6	-1.1
Condit. Reinf. lever reinforcers received	2.6	3.7	4.2	-1.6	-2.0	1.6	2.1	2.1	-2.1	-1.9
Conditioned reinforcement - actives	1.7	1.7	2.6	-1.3	-1.4	1.6	1.4	1.4	-1.3	-0.1
Conditioned reinforcement - inactives	0.5	0.6	1.1	-0.3	-0.8	1.0	0.9	0.9	-0.7	-0.4
Conditioned locomotion	4.9	5.8	7.8	-2.8	-2.6	2.6	2.6	2.6	-2.2	-1.2
Patch foraging indifference point 0 sec	0.6	1.0	2.1	-0.8	-1.1	1.4	1.1	1.1	-0.7	-0.2
Patch foraging indifference point AUC	0.3	0.3	0.6	-0.5	-0.5	0.6	0.5	0.5	-0.3	-0.8
Delay disc. indifference point, 0s delay	0.0	0.1	0.2	-0.2	0.1	-0.2	-0.2	-0.2	-0.0	-0.5
Delay disc. indifference point, 16s delay	0.5	0.5	0.7	-0.6	-0.7	0.6	0.7	0.7	-0.6	-0.8
Delay disc. indifference point, 2s delay	0.3	0.3	1.7	0.0	0.1	-0.3	-0.1	-0.1	-0.7	-1.3
Delay disc. indifference point, 24s delay	0.7	0.7	1.5	-0.7	-0.9	1.2	0.9	0.9	-0.4	0.3
Delay disc. indifference point, 4s delay	0.2	0.2	0.4	0.5	0.6	-0.6	-0.5	-0.5	-0.1	-0.3
Delay disc. indifference point, 8s delay	0.5	0.5	2.4	-0.1	-0.1	-0.1	0.2	0.2	-0.9	-1.5
Indifference point function ln k	0.5	0.7	1.2	-0.5	-0.8	0.8	0.8	0.8	-1.1	-0.9
Indifference point function log k	0.5	0.7	1.2	-0.5	-0.8	0.8	0.8	0.8	-1.1	-0.9
Patch foraging total patch changes 0 sec	0.7	1.1	2.1	-0.9	-1.1	1.5	1.1	1.1	-0.8	-0.5
Patch foraging total patch changes 12 sec	0.6	0.8	1.2	-0.7	-0.9	1.1	1.0	1.0	-0.9	-0.6
Patch foraging total patch changes 18 sec	0.5	0.7	1.3	0.8	0.7	-0.3	-0.8	-0.8	1.2	1.0
Patch foraging total patch changes 24 sec	1.0	1.3	2.0	-1.1	-1.2	1.4	1.2	1.2	-0.9	-0.5
Patch foraging total patch changes 6 sec	1.8	2.6	4.3	-1.4	-1.7	2.1	1.7	1.7	-1.6	-1.1
Patch foraging time to switch 0 sec	0.9	1.4	2.1	0.9	1.2	-1.2	-1.3	-1.3	1.0	1.5
Patch foraging water rate 0 sec	0.1	0.1	0.6	0.0	-0.0	0.1	0.0	0.0	-0.4	-0.8
Patch foraging water rate 12 sec	0.5	0.8	1.2	-0.8	-0.9	1.0	0.9	0.9	-1.1	-0.5
Patch foraging water rate 18 sec	1.7	2.2	2.7	-1.6	-1.5	1.4	1.5	1.5	-1.6	-1.1
Patch foraging water rate 24 sec	0.2	0.2	0.5	0.7	0.6	-0.5	-0.5	-0.5	-0.1	-0.3
Patch foraging water rate 6 sec	0.0	0.0	0.1	-0.0	0.1	-0.0	-0.1	-0.1	-0.3	0.2
Seeking ratio, delayed vs. immediate footshock	0.5	0.6	2.7	0.1	-0.3	0.5	0.3	0.3	-1.0	-1.6
Distance traveled before self-admin	0.5	0.6	1.4	0.2	0.6	-0.4	-0.7	-0.7	1.0	1.2
Distance traveled after self-admin	0.3	0.3	0.7	-0.8	-0.5	0.8	0.4	0.4	-0.4	-0.0
Extensor digitorum longus weight	0.1	0.6	1.7	-1.3	-0.7	1.0	0.5	0.5	-0.5	0.3
Bone: elastic displacement	0.7	0.8	2.1	1.2	0.8	-0.7	-0.8	-0.8	1.5	-0.0
Bone: elastic work	0.1	0.1	0.9	0.1	-0.0	0.2	0.0	0.0	0.3	-0.9
Bone: endosteal estimation	0.9	2.0	2.7	-1.1	-1.4	1.3	1.5	1.5	-1.5	-1.6
Bone: endosteal perimeter	1.6	3.3	4.7	-1.8	-1.8	1.7	1.8	1.8	-2.2	-1.5
Epididymis fat weight	0.5	1.2	1.8	0.7	1.3	-1.2	-1.3	-1.3	1.0	0.9
Delta time in closed arm before/after self-admin	2.0	1.9	4.1	-0.9	-1.3	1.3	1.4	1.4	-2.0	-1.1
Delta time in open arm before/after self-admin	1.0	1.0	2.8	1.0	0.6	-0.6	-0.4	-0.4	1.7	1.5
Diff in mean of infusions in LGA sessions	0.2	0.2	0.8	-0.5	-0.2	0.3	0.1	0.1	0.1	0.9
Delay discount exponential model param	0.6	0.7	2.4	0.4	0.4	-0.3	-0.5	-0.5	1.2	1.5
Extinction: sum of active levers before priming	0.4	0.4	0.7	0.5	0.6	-0.3	-0.7	-0.7	0.8	0.3
Active lever presses in extinction session 6	0.8	0.8	1.7	0.4	0.8	-0.6	-0.8	-0.8	1.3	1.1
Bone: final force	0.5	0.8	1.4	-1.1	-0.8	0.9	0.7	0.7	-1.2	-0.9
Bone: final moment	0.3	0.4	0.8	-0.8	-0.5	0.6	0.4	0.4	-0.9	-0.6
Food consumed during 24 hour testing period	1.0	1.3	1.6	-0.9	-1.3	1.3	1.3	1.3	-0.6	-1.1
Glucose	0.5	0.8	1.2	-0.4	-1.0	1.1	1.1	1.1	-0.7	-0.7
Heart weight	0.7	1.0	3.8	-0.3	-0.7	0.5	0.8	0.8	-1.1	-1.9
Delay discount hyperbolic model param	0.5	0.6	2.3	0.3	0.3	-0.1	-0.3	-0.3	1.1	1.5
Intermittent access intake day 1-15 change	1.5	1.5	1.9	1.1	1.4	-1.4	-1.4	-1.4	1.0	0.7
Intermittent access intake escalation	1.5	1.5	2.1	1.2	1.4	-1.5	-1.4	-1.4	1.0	0.4
Intermittent access intake escalation 2	4.7	4.7	6.4	2.0	2.5	-2.5	-2.5	-2.5	1.8	0.7
Intermitt. access day 1 inactive lever presses	0.6	0.6	1.2	-0.8	-0.9	1.1	0.8	0.8	-0.6	-0.2
Intermitt. access day 15 inactive lever presses	1.7	1.9	3.0	-1.3	-1.4	1.7	1.4	1.4	-1.4	-0.8
Intermitt. access escalation Index	1.5	1.4	1.7	1.3	1.2	-1.0	-1.2	-1.2	1.2	0.9
Intermittent access day 1 total infusions	0.7	0.9	1.4	-1.2	-0.8	1.0	0.7	0.7	-1.1	-0.9
Intermittent access day 15 total infusions	0.1	0.1	0.3	-0.1	0.1	0.0	-0.2	-0.2	-0.4	-0.5
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.1	-0.0	0.2	0.1	-0.3	-0.3	-0.1	0.0
Intermittent access total infusions	0.4	0.4	0.8	-0.8	-0.5	0.8	0.4	0.4	-0.9	-0.6
Intermittent access day 1 locomotion	0.6	0.6	1.0	-0.8	-0.8	0.6	0.8	0.8	-1.0	-0.7
Intermittent access day 15 total locomotion	1.5	1.7	2.5	-1.2	-1.3	1.4	1.3	1.3	-1.6	-0.8
Intermittent access total locomotion	1.3	1.5	2.0	-1.4	-1.3	1.4	1.2	1.2	-1.4	-0.7
Intermittent access standard deviation	0.0	0.0	0.0	-0.2	-0.0	0.1	0.0	0.0	-0.1	0.2
Left kidney weight	2.2	6.1	8.8	-3.0	-2.7	2.8	2.6	2.6	-1.7	-1.5
Right kidney weight	2.9	8.0	11.9	-3.4	-3.1	3.3	3.0	3.0	-2.1	-1.1
Cocaine induced anxiety	0.0	0.0	0.1	0.1	0.1	0.0	-0.1	-0.1	0.0	-0.4
Post-drug Anxiety	0.3	0.4	0.6	0.3	0.7	-0.6	-0.7	-0.7	0.7	0.3
Baseline Anxiety	0.4	0.5	1.1	0.3	0.6	-0.5	-0.6	-0.6	0.8	1.0
Tail length	7.2	21.9	25.7	-5.1	-4.8	4.6	4.6	4.6	-4.6	-4.5
Length with tail	8.6	31.3	35.9	-6.0	-5.8	5.6	5.7	5.7	-4.9	-5.4
Length without tail	2.0	4.5	5.7	-2.2	-2.3	2.3	2.4	2.4	-1.4	-1.5
Times rat made contact with spout	1.0	1.2	2.1	-1.0	-1.0	1.0	1.0	1.0	-1.0	-1.5
Lifetime Intake	0.4	0.5	1.0	-0.7	-0.5	0.8	0.4	0.4	-1.0	-0.7
Liver weight, left	0.2	0.3	0.9	-0.9	-0.2	0.5	0.1	0.1	-0.0	0.9
Liver weight, right	2.1	3.5	5.3	-2.3	-1.9	2.2	1.8	1.8	-2.0	-0.7
Locomotor activity	1.0	1.5	3.0	-1.0	-1.2	1.2	1.2	1.2	-1.7	-0.9
Locomotor testing distance	0.1	0.2	0.6	0.8	0.3	-0.3	-0.3	-0.3	0.3	0.5
Locomotor testing rearing	0.5	0.8	1.3	1.1	0.8	-0.9	-0.7	-0.7	0.8	1.1
Locomotion in novel chamber	2.3	2.8	4.4	-0.8	-1.6	1.6	1.8	1.8	-1.8	-2.1
Locomotion in novel chamber post-restriction	1.1	1.3	2.6	-1.1	-0.9	0.9	0.9	0.9	-1.6	-1.5
Fecal boli incidents, locomotor time 1	2.2	2.5	4.3	-1.5	-1.8	2.1	1.8	1.8	-0.6	0.4
Change in fecal boli incidents, locomotor task	0.7	0.7	1.2	1.1	0.9	-1.1	-0.8	-0.8	0.1	-0.5
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.3	0.5	0.5	-0.3	-0.5	-0.5	0.2	0.3
Bouts of movement, locomotor time 1	0.8	0.8	1.3	-0.8	-1.0	1.1	1.0	1.0	-0.8	-0.4
Total resting periods, locomotor time 1	1.2	1.4	2.2	-0.9	-1.3	1.5	1.4	1.4	-1.0	-0.2
Rest time, locomotor task time 1	1.1	1.2	2.0	-1.1	-1.2	1.4	1.2	1.2	-0.8	-0.3
Distance moved, locomotor task time 1	0.5	0.5	1.0	0.3	0.7	-0.6	-0.7	-0.7	1.0	0.7
Vertical activity count, locomotor time 1	0.9	1.0	1.7	0.7	1.1	-1.3	-1.1	-1.1	0.7	0.6
Time >=10cm from walls, locomotor time 2	0.5	0.5	1.1	-1.0	-0.7	0.9	0.6	0.6	-0.3	-0.3
Bouts of movement, locomotor time 2	0.8	0.8	1.2	-1.0	-0.9	0.8	0.8	0.8	-1.1	-0.8
Total resting periods, locomotor time 2	0.8	0.9	1.0	-1.0	-1.0	0.9	1.0	1.0	-0.9	-0.9
Rest time, locomotor task time 2	2.4	2.7	3.9	-1.0	-1.8	1.7	2.0	2.0	-1.5	-1.3
Distance moved, locomotor task time 2	1.6	1.9	4.4	0.1	1.2	-0.8	-1.4	-1.4	1.7	2.1
Vertical activity count, locomotor time 2	4.2	4.5	8.5	1.0	2.1	-2.0	-2.2	-2.2	2.1	2.9
Light reinforcement 1	0.1	0.3	0.6	-0.8	-0.5	0.6	0.5	0.5	0.0	0.4
Light reinforcement 2	0.3	0.4	1.4	-0.2	-0.1	0.3	0.2	0.2	0.9	1.2
Bone: marrow area	0.9	1.9	2.7	-1.0	-1.4	1.2	1.4	1.4	-1.5	-1.6
Bone: maximum diameter	0.5	0.9	1.8	-1.2	-0.8	0.8	0.8	0.8	-1.4	-0.6
Bone: maximum force	0.8	1.5	2.4	-1.6	-1.1	1.2	1.0	1.0	-1.5	-0.9
Bone: maximum moment	0.5	0.9	1.7	-1.3	-0.8	1.0	0.7	0.7	-1.2	-0.7
Mean time between licks in bursts	1.8	2.5	3.8	1.5	1.8	-2.0	-1.8	-1.8	1.0	0.7
Mean num. licks in bursts	0.4	0.5	1.0	1.0	0.8	-0.7	-0.7	-0.7	0.6	-0.0
Cd content in liver	1.2	1.3	1.8	1.3	1.2	-1.1	-1.1	-1.1	1.3	0.9
Co content in liver	0.1	0.1	0.5	-0.1	0.1	0.1	-0.1	-0.1	0.7	0.0
Cu content in liver	0.6	0.8	2.3	0.7	0.5	-0.1	-0.5	-0.5	1.3	1.5
Fe content in liver	3.9	4.6	9.4	1.7	2.1	-1.7	-2.2	-2.2	1.8	3.1
K content in liver	0.8	0.8	2.0	-1.4	-0.9	1.0	0.8	0.8	-0.2	-0.2
Mg content in liver	1.3	1.4	2.8	-1.7	-1.3	1.4	1.2	1.2	-0.3	-0.2
Mn content in liver	0.4	0.5	0.7	-0.7	-0.7	0.5	0.8	0.8	-0.5	-0.8
Na content in liver	2.1	2.2	2.7	-1.4	-1.6	1.6	1.6	1.6	-1.2	-1.2
Rb content in liver	3.4	4.2	5.1	1.8	2.2	-2.2	-2.3	-2.3	1.9	1.6
Se content in liver	1.3	1.6	2.7	1.1	1.3	-0.9	-1.3	-1.3	1.6	1.3
Sr content in liver	1.0	0.9	2.1	-1.4	-1.0	0.8	0.9	0.9	-0.9	-0.8
Zn content in liver	1.5	1.7	3.2	-1.1	-1.5	1.8	1.5	1.5	-0.7	-0.4
Bone: minimum diameter	0.5	1.0	2.1	-1.1	-0.7	0.6	0.7	0.7	-1.5	-1.3
Time in familiar zone, hab. session 1	0.3	0.3	0.5	0.7	0.5	-0.7	-0.5	-0.5	0.4	0.2
Time in novel zone, hab. session 1	0.1	0.1	0.2	-0.1	0.0	0.1	-0.0	-0.0	-0.4	0.5
Total zone transitions, hab. session 1	3.3	4.6	5.9	-2.2	-2.1	1.8	2.0	2.0	-2.4	-2.4
Total locomotion distance, hab. session 1	0.1	0.1	0.6	-0.4	-0.1	-0.1	0.0	0.0	-0.3	-0.8
Locomotion velocity, hab. session 1	0.2	0.2	0.7	-0.7	-0.4	0.3	0.3	0.3	-0.2	-0.8
Time in familiar zone, hab. session 2	1.9	2.0	2.6	1.4	1.6	-1.6	-1.6	-1.6	1.1	0.7
Time in novel zone, hab. session 2	0.8	0.8	1.1	-0.8	-1.0	0.8	1.0	1.0	-1.0	-0.5
Total zone transitions, hab. session 2	0.2	0.3	0.5	-0.6	-0.6	0.5	0.7	0.7	0.4	-0.2
Total locomotion distance, hab. session 2	0.2	0.3	1.7	0.2	0.1	-0.3	-0.1	-0.1	1.3	0.1
Locomotion velocity, hab. session 2	0.2	0.3	1.8	0.2	0.1	-0.2	-0.1	-0.1	1.4	0.1
Novel to familiar place preference ratio	0.0	0.0	0.1	0.4	0.1	-0.1	-0.0	-0.0	-0.0	-0.0
Novelty place preference	0.0	0.0	0.2	0.4	0.1	-0.2	-0.0	-0.0	-0.0	0.1
Time in novel zone, NPP test	0.0	0.0	0.1	0.4	-0.0	-0.1	0.1	0.1	-0.2	-0.1
Total zone transitions, NPP test	1.4	2.0	2.9	-1.7	-1.5	1.4	1.4	1.4	-0.9	-1.3
Total locomotion distance, NPP test	0.8	1.1	1.9	-1.4	-1.1	1.0	1.0	1.0	-0.4	-1.0
Locomotion velocity, NPP test	0.6	0.9	1.9	-1.4	-1.0	0.9	0.9	0.9	-0.3	-0.9
Intraocular pressure	1.4	2.0	4.8	0.8	1.3	-1.1	-1.4	-1.4	1.3	2.2
Delta distance traveled before/after self-admin	0.6	0.6	1.2	-0.5	-0.7	0.7	0.7	0.7	-1.1	-1.0
Delta ambulatory time before/after self-admin	0.2	0.3	0.7	-0.4	-0.4	0.5	0.4	0.4	-0.8	-0.6
Parametrial fat weight	0.1	0.1	0.4	-0.7	0.2	0.1	-0.4	-0.4	0.1	-0.1
Pavlov. Cond. lever latency	0.7	0.9	2.1	1.5	0.9	-1.0	-0.8	-0.8	0.9	0.7
Pavlov. Cond. magazine entry latency	2.7	3.5	4.0	-2.0	-1.9	1.7	1.8	1.8	-1.9	-2.0
Pavlov. Cond. change in total contacts	2.5	2.7	4.1	-2.0	-1.7	1.6	1.6	1.6	-1.6	-1.2
Pavlov. Cond. index score	2.5	3.2	4.8	-2.2	-1.8	1.7	1.7	1.7	-1.7	-1.6
Pavlov. Cond. latency score	2.2	2.8	4.0	-2.0	-1.7	1.7	1.6	1.6	-1.5	-1.4
Pavlov. Cond. lever contacts	1.1	1.3	2.6	-1.6	-1.1	1.1	1.0	1.0	-1.1	-0.8
Pavlov. Cond. magazine entry number	3.8	4.7	6.1	2.5	2.2	-2.0	-2.1	-2.1	2.2	2.3
Pavlov. Cond. intertrial magazine entries	0.5	0.7	1.3	1.1	0.7	-0.5	-0.6	-0.6	1.0	1.0
Pavlov. Cond. lever-magazine prob. diff.	1.8	2.2	3.7	-1.9	-1.5	1.4	1.4	1.4	-1.5	-1.4
Pavlov. Cond. response bias	2.5	3.0	4.8	-2.2	-1.7	1.5	1.6	1.6	-1.8	-1.7
Pavlov. Cond. lever latency	0.3	0.3	1.1	0.4	0.3	0.0	-0.3	-0.3	0.9	1.0
Pavlov. Cond. magazine entry latency	0.5	0.5	1.2	0.5	0.8	-1.1	-0.9	-0.9	-0.1	0.0
Pavlov. Cond. change in total contacts	0.3	0.4	1.7	-0.4	-0.5	0.3	0.5	0.5	-1.3	-0.7
Pavlov. Cond. index score	0.3	0.4	1.3	-0.4	-0.3	0.0	0.3	0.3	-1.1	-1.0
Pavlov. Cond. latency score	0.2	0.3	1.0	-0.4	-0.3	0.0	0.3	0.3	-1.0	-0.9
Pavlov. Cond. lever contacts	0.1	0.1	0.4	-0.1	-0.1	-0.2	0.1	0.1	-0.6	-0.6
Pavlov. Cond. magazine entry number	0.1	0.2	0.3	-0.2	-0.5	0.5	0.5	0.5	0.3	-0.2
Pavlov. Cond. intertrial magazine entries	1.6	2.1	3.0	-1.0	-1.5	1.3	1.6	1.6	-1.3	-1.7
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	1.1	-0.5	-0.3	0.1	0.3	0.3	-1.0	-0.8
Pavlov. Cond. response bias	0.1	0.2	0.6	0.0	0.1	-0.4	-0.1	-0.1	-0.8	-0.6
Time in closed arm before self-admin	0.2	0.2	0.7	-0.2	0.1	-0.1	-0.2	-0.2	0.8	0.9
Time in closed arm after self-admin	1.7	1.7	3.1	-1.7	-1.4	1.4	1.3	1.3	-1.3	-0.1
Time in open arm before self-admin	0.9	0.9	1.6	1.1	1.2	-0.8	-1.3	-1.3	0.1	-0.5
Time in open arm after self-admin	1.1	1.2	2.2	1.2	1.0	-0.7	-0.9	-0.9	1.3	1.5
Bone: periosteal estimation	0.6	1.3	2.6	-1.3	-1.0	0.9	0.9	0.9	-1.6	-1.2
Bone: periosteal perimeter	1.1	1.9	3.1	-1.7	-1.3	1.2	1.2	1.2	-1.8	-1.2
Bone: post-yield work	0.3	0.4	1.9	-0.0	0.4	-0.3	-0.5	-0.5	0.3	1.4
Progressive ratio test 1 active lever presses	3.2	3.3	6.4	-2.1	-1.6	1.7	1.5	1.5	-2.5	-1.5
Progressive ratio test 1 breakpoint	2.6	2.7	5.3	-2.0	-1.4	1.5	1.3	1.3	-2.3	-1.4
Progressive ratio test 1 inactive lever presses	1.8	1.9	3.8	-1.5	-1.2	1.2	1.1	1.1	-2.0	-1.5
Progressive ratio test 2 active lever presses	0.4	0.4	1.4	-0.4	-0.3	0.5	0.2	0.2	-1.2	-1.0
Progressive ratio test 2 breakpoint	0.4	0.5	1.5	-0.5	-0.3	0.4	0.2	0.2	-1.2	-1.0
Progressive ratio test 2 inactive lever presses	1.6	1.9	3.7	-0.9	-1.1	1.3	1.1	1.1	-1.9	-1.8
Incentive Sensitization - Responses	0.2	0.2	0.5	0.7	-0.0	0.3	0.1	0.1	-0.5	-0.5
Incentive Sensitization - Breakpoint	0.1	0.1	0.5	0.7	0.0	0.2	0.0	0.0	-0.5	-0.5
Sum of active levers in priming session hrs 5-6	0.3	0.3	1.1	0.4	0.4	-0.3	-0.4	-0.4	0.1	-1.0
Progressive ratio	2.3	2.6	3.9	-2.0	-1.7	1.8	1.6	1.6	-1.3	-1.4
Food seeking constrained by brief footshock	0.0	0.0	0.1	0.3	0.2	-0.2	-0.2	-0.2	0.2	0.2
Seeking ratio, punishment vs. effort	1.5	1.8	2.8	1.7	1.4	-1.5	-1.3	-1.3	1.1	1.1
Retroperitoneal fat weight	0.0	0.1	0.5	-0.7	0.0	0.2	-0.2	-0.2	-0.3	0.3
Reaction time number correct	0.4	0.6	0.8	-0.7	-0.8	0.9	0.9	0.9	-0.4	-0.5
Reaction time mean minus median	0.5	0.7	1.7	-1.3	-0.5	0.2	0.4	0.4	-0.9	-1.2
Reaction time mean minus median AUC	0.6	0.8	1.9	-1.4	-0.8	0.6	0.7	0.7	-0.7	-1.0
Reaction time num false alarms	1.8	2.4	3.2	-1.8	-1.7	1.6	1.7	1.7	-1.1	-1.1
Reaction time num false alarms AUC	1.5	2.1	3.3	-1.8	-1.6	1.5	1.5	1.5	-1.0	-1.0
Reaction time trials correct on left	0.4	0.6	0.8	-0.7	-0.8	0.9	0.9	0.9	-0.4	-0.5
Reaction time trials on left	0.4	0.5	0.7	-0.7	-0.8	0.8	0.9	0.9	-0.5	-0.6
Reaction time mean	1.4	1.9	3.3	1.4	1.5	-1.8	-1.5	-1.5	1.1	0.6
Reaction time mean AUC	2.2	3.0	5.0	1.7	1.9	-2.2	-1.9	-1.9	1.4	0.6
Median of all reaction times	3.1	4.2	5.9	2.3	2.2	-2.4	-2.1	-2.1	1.8	1.3
Reaction time omissions	0.4	0.6	1.2	0.8	0.8	-1.1	-0.8	-0.8	0.6	0.1
Reaction time false alarm rate	0.7	0.9	1.7	-1.3	-1.0	1.0	0.9	0.9	-0.7	-0.6
Reaction time premature initiation rate	2.8	3.7	5.0	-1.6	-2.1	1.9	2.2	2.2	-1.6	-1.7
Reaction time premature initiations	3.1	4.3	5.7	-1.7	-2.3	1.9	2.4	2.4	-1.7	-2.0
Std. dev. reaction times	0.1	0.1	0.2	-0.5	0.0	-0.3	-0.1	-0.1	-0.3	-0.5
Reaction time trials completed	0.4	0.5	0.7	-0.7	-0.8	0.8	0.9	0.9	-0.5	-0.6
Reaction time trials AUC	0.3	0.5	0.7	-0.6	-0.8	0.8	0.8	0.8	-0.5	-0.4
Run reversals in cocaine runway, females	1.2	1.2	2.3	1.2	1.2	-1.5	-1.1	-1.1	0.7	-0.5
Run reversals in cocaine runway, males	0.1	0.1	0.2	0.2	0.3	0.1	-0.3	-0.3	0.0	0.5
Latency to leave start box in cocaine runway	0.1	0.1	0.2	-0.3	0.3	-0.2	-0.5	-0.5	0.3	0.1
Latency to leave start box in cocaine runway, F	0.3	0.3	0.6	0.0	0.6	-0.6	-0.8	-0.8	0.3	0.3
Latency to leave start box in cocaine runway, M	0.2	0.2	0.2	-0.5	-0.4	0.4	0.4	0.4	0.1	-0.4
Std. dev. time between licks in bursts	0.3	0.3	0.8	-0.3	-0.5	0.4	0.6	0.6	-0.1	-0.9
Total sessions with >9 infusions	1.1	1.2	2.4	-1.3	-0.9	1.0	0.8	0.8	-1.6	-1.1
Short access day 1 total inactive lever presses	5.1	5.7	6.2	-2.0	-2.5	2.4	2.5	2.5	-2.4	-2.5
Short access day 10 total inactive lever presses	0.5	0.6	1.2	-0.8	-0.7	0.6	0.7	0.7	-0.5	-1.1
Short access day 1 total infusions	0.1	0.1	0.2	-0.3	0.2	-0.1	-0.3	-0.3	-0.3	-0.5
Short access day 10 total infusions	2.1	2.3	3.3	-1.7	-1.4	1.7	1.3	1.3	-1.8	-1.3
Short access total infusions	0.6	0.7	1.4	-0.8	-0.7	1.0	0.6	0.6	-1.2	-0.7
Short access day 1 locomotion	0.4	0.4	1.2	-1.1	-0.5	0.6	0.4	0.4	-0.6	-0.4
Short access day 10 total locomotion	0.4	0.4	1.2	-0.6	-0.6	0.3	0.6	0.6	-0.7	-1.1
Short access total locomotion	1.1	1.2	1.8	-1.3	-1.0	1.0	0.9	0.9	-1.4	-0.9
One hour access (0.3 mA shock)	0.3	0.3	0.8	-0.0	-0.4	0.4	0.5	0.5	-0.8	-0.9
Compulsive drug intake	0.5	0.5	1.7	1.3	0.4	-0.7	-0.2	-0.2	0.6	0.6
One hour access (shock baseline)	0.7	0.8	1.3	-1.0	-0.7	1.1	0.6	0.6	-1.2	-1.1
Social response proportion	0.2	0.2	0.7	0.2	0.4	-0.5	-0.4	-0.4	-0.5	-0.8
Social responses	3.6	4.6	6.2	-2.1	-2.1	1.8	2.1	2.1	-2.5	-2.2
Social time	0.3	0.3	0.5	0.5	0.6	-0.6	-0.6	-0.6	0.0	0.7
Soleus weight	0.2	0.4	1.7	-1.3	-0.3	0.0	0.1	0.1	-1.0	-0.5
Bone: stiffness	3.0	4.8	6.6	-2.3	-2.2	2.1	2.2	2.2	-2.6	-1.8
Tibialis anterior weight	0.1	0.3	0.9	-1.0	-0.5	0.7	0.4	0.4	-0.5	-0.3
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	0.0	0.2	0.4	-0.3	-0.3	0.2	0.4
Time to tail flick, vehicle, after self-admin	1.1	1.1	2.5	-1.6	-1.1	1.5	1.0	1.0	-0.1	0.1
Time to tail flick, test, before self-admin	1.7	1.6	3.3	-1.6	-1.4	1.8	1.3	1.3	-0.5	-0.3
Time to tail flick, test, after self-admin	0.2	0.2	0.8	0.1	-0.3	0.3	0.4	0.4	0.9	0.5
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.5	-0.6	-0.4	0.5	0.4	0.4	0.7	0.4
Delta time to tail flick, test, before/after SA	0.3	0.3	0.6	0.8	0.3	-0.6	-0.2	-0.2	0.7	0.4
Tibia length	0.6	1.6	2.4	-1.2	-1.1	1.0	1.1	1.1	-1.6	-1.6
Ambulatory time before self-admin	0.3	0.3	1.2	-0.6	0.1	0.2	-0.2	-0.2	0.6	1.1
Ambulatory time after self-admin	0.6	0.6	1.8	-1.4	-0.7	1.0	0.6	0.6	-0.5	0.0
Bone: tissue strength	0.7	0.6	1.0	0.7	0.9	-0.7	-1.0	-1.0	0.2	0.7
Total heroin consumption	0.3	0.3	0.5	-0.2	0.5	-0.2	-0.7	-0.7	0.7	0.7
Bone: trabecular number	1.1	1.7	2.4	1.2	1.5	-1.5	-1.6	-1.6	0.9	0.6
Bone: trabecular spacing	0.1	0.2	0.4	-0.5	-0.5	0.6	0.4	0.4	0.3	0.1
Bone: trabecular thickness	0.7	0.9	1.3	0.8	0.9	-0.8	-0.9	-0.9	1.0	1.2
Bone: trabecular tissue density	3.1	4.4	5.6	-2.1	-2.3	2.4	2.3	2.3	-1.6	-1.6
Water consumed over 24 hours	1.8	2.2	4.6	-1.4	-1.4	1.1	1.4	1.4	-1.4	-2.2
Number of responses in last shaping day	0.2	0.2	0.4	-0.1	0.4	-0.3	-0.6	-0.6	0.2	0.6