Hub : Genes

Mtfr1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Mtfr1 0.29 0.11 0.0e+00 0.18 0.2 0.2 0.2 3.7e-20 5.0e-22 5.0e-22 2.8e-22
2 Adipose alternative polyA XM_006232179.5 0.03 0.02 4.6e-03 0.01 0.01 0.01 0 5.9e-02 5.3e-02 6.6e-02 1.0e-01
3 Adipose mRNA stability Mtfr1 0.08 0.05 6.9e-06 0.04 0.03 0.02 0.03 5.4e-05 1.5e-04 5.2e-03 1.8e-04
4 NAcc gene expression Mtfr1 0.08 0.04 4.7e-12 0.08 0.05 0.06 0.06 1.3e-11 3.4e-08 5.1e-09 9.6e-10
5 Liver alternative polyA XM_006232179.5 0.04 0.03 1.6e-04 0.02 0.02 0.01 0.01 6.0e-03 2.6e-03 1.2e-02 9.4e-03
6 NAcc mRNA stability Mtfr1 0.03 0.02 5.6e-05 0.03 0.02 0.02 0.02 9.9e-05 1.5e-04 4.1e-04 6.2e-04
7 pVTA gene expression Mtfr1 0.05 0.03 3.2e-04 0.04 0.04 0.04 0.04 3.9e-04 5.7e-04 2.4e-04 2.1e-04
8 pVTA alternative polyA XM_006232179.5 0.04 0.02 2.7e-03 0.02 0.01 0.02 0.01 9.9e-03 2.1e-02 7.5e-03 3.1e-02
9 pVTA alternative polyA NM_001100977.2 0.04 0.02 2.9e-03 0.02 0.01 0.02 0.01 1.1e-02 2.5e-02 8.1e-03 3.3e-02
10 Liver alternative polyA NM_001100977.2 0.04 0.03 3.1e-04 0.02 0.02 0.01 0.01 5.3e-03 3.9e-03 6.8e-03 9.6e-03
11 pVTA alternative polyA NM_001100977.2 0.03 0.02 7.8e-03 0.02 0.01 0.02 0.01 7.4e-03 3.5e-02 7.5e-03 3.0e-02
12 pVTA alternative polyA XM_006232179.5 0.03 0.02 8.0e-03 0.02 0.01 0.02 0.01 5.8e-03 2.9e-02 6.3e-03 2.1e-02
13 PL gene expression Mtfr1 0.09 0.07 3.9e-04 0.03 0.02 0.02 0.03 2.5e-04 1.4e-03 1.2e-03 5.5e-04
14 Liver alternative polyA NM_001100977.2 0.03 0.02 8.4e-04 0.01 0.01 0.01 0.01 4.8e-02 1.7e-02 6.8e-02 5.7e-02
15 Liver alternative polyA XM_006232179.5 0.04 0.03 2.3e-04 0.01 0.02 0.02 0.01 6.9e-03 2.4e-03 3.0e-03 7.5e-03
16 Liver isoform ratio NM_001100977.2 0.07 0.04 5.1e-05 0.03 0.02 0.02 0.02 5.2e-04 1.7e-03 2.4e-03 2.7e-03
17 Liver mRNA stability Mtfr1 0.11 0.06 1.2e-07 0.05 0.04 0.04 0.05 1.1e-06 4.1e-05 1.8e-05 5.9e-06
18 Liver isoform ratio XM_063281998.1 0.05 0.04 1.8e-03 0 0.01 0 0 2.6e-01 3.3e-02 3.1e-01 9.4e-02
19 Adipose gene expression Mtfr1 0.09 0.05 2.3e-08 0.06 0.05 0.04 0.05 4.9e-07 1.3e-06 1.2e-05 1.2e-06
20 IC alternative TSS XM_063281993.1 0.08 0.05 4.1e-03 0.02 0.02 0.01 0.01 3.4e-02 4.1e-02 1.2e-01 1.1e-01
21 Adipose alternative polyA NM_001100977.2 0.03 0.02 6.0e-03 0.01 0.01 0.01 0 3.6e-02 5.0e-02 5.8e-02 9.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
Bone: apparent density0.71.22.01.21.11.11.11.01.01.01.3-1.3-0.9-1.11.11.3-1.21.0-1.01.00.11.2-1.4-0.4
Area under the delay curve0.20.20.6-0.6-0.5-0.7-0.8-0.5-0.5-0.50.1-0.10.5-0.00.0-0.60.4-0.50.1-0.1-0.40.0-0.30.5
BMI with tail1.75.79.7-2.9-2.4-3.1-3.1-2.4-2.8-2.8-2.82.82.22.4-2.4-2.82.5-2.21.7-1.7-1.0-1.82.10.9
BMI without tail2.06.18.5-2.9-2.6-2.9-2.9-2.6-2.7-2.7-2.62.62.52.5-2.5-2.72.7-2.52.1-2.1-1.2-2.12.21.7
Body weight1.46.09.2-3.0-2.4-3.0-2.9-2.4-2.7-2.7-3.03.02.22.2-2.2-2.72.9-2.31.8-1.8-0.1-2.03.01.0
Weight adjusted by age0.10.10.6-0.5-0.2-0.3-0.3-0.3-0.0-0.0-0.50.50.30.4-0.4-0.10.6-0.40.1-0.10.8-0.20.40.2
Bone surface0.00.00.10.00.1-0.00.00.10.00.00.3-0.3-0.1-0.40.40.1-0.20.1-0.10.1-0.20.2-0.3-0.1
Bone volume0.00.00.0-0.00.0-0.00.10.00.10.10.1-0.1-0.0-0.10.10.1-0.10.00.0-0.0-0.10.1-0.10.1
Breakpoint value in progressive ratio session0.91.12.5-0.7-1.0-0.6-0.8-1.0-1.2-1.2-1.21.21.01.6-1.6-0.60.7-0.91.1-1.1-1.1-1.10.81.0
Number of licking bursts0.71.12.3-1.1-1.0-1.0-1.0-1.0-0.9-0.9-1.51.51.01.1-1.1-0.91.3-1.01.0-1.00.1-1.01.40.6
Context. condit. distance diff. score0.20.21.9-0.00.20.10.10.2-0.0-0.0-0.00.0-0.1-0.40.40.10.20.0-0.60.61.40.80.6-0.2
Locomotion velocity, session 10.20.30.7-0.8-0.7-0.9-0.8-0.7-0.4-0.4-0.10.10.70.1-0.1-0.50.6-0.70.3-0.3-0.4-0.20.10.6
Locomotion distance, session 10.10.10.5-0.10.1-0.5-0.40.2-0.0-0.00.3-0.3-0.3-0.20.2-0.1-0.40.4-0.30.3-0.70.3-0.6-0.7
Locomotion velocity, session 22.32.74.6-2.0-1.9-2.2-2.1-1.9-1.8-1.8-1.11.11.81.2-1.2-1.91.7-1.81.4-1.4-1.6-1.51.01.4
Locomotion distance, session 20.20.21.00.10.3-0.3-0.30.40.20.20.3-0.3-0.6-0.30.30.1-0.50.6-0.70.7-0.40.4-0.6-1.0
Locomotion velocity, session 30.91.01.8-1.2-1.0-1.3-1.3-1.0-1.3-1.3-1.01.01.00.8-0.8-1.21.1-1.00.6-0.6-0.4-0.71.00.6
Locomotion distance, session 30.80.91.2-1.1-1.0-1.0-1.0-1.0-1.0-1.0-1.01.01.10.9-0.9-1.01.1-1.10.5-0.5-0.2-0.70.80.8
Stereotopy head waving bouts, day 30.40.51.30.60.70.60.60.71.11.10.7-0.7-0.6-0.80.81.0-0.50.6-0.50.50.80.6-0.5-0.4
Stereotopy head waving duration, day 30.40.51.00.80.80.70.80.81.01.00.7-0.7-0.8-0.60.60.9-0.80.8-0.10.10.00.4-0.6-0.6
Locomotion velocity, session 73.84.25.42.22.32.12.22.32.32.31.8-1.8-2.3-1.81.82.3-2.12.2-1.91.91.61.8-1.6-2.0
Locomotion distance, session 72.83.65.72.22.12.32.32.12.32.31.5-1.5-2.0-1.41.42.4-2.02.0-1.71.71.51.5-1.3-1.5
Stereotopy head waving bouts, day 70.40.50.9-0.9-0.8-0.9-0.9-0.8-0.5-0.5-0.70.70.80.6-0.6-0.60.9-0.80.4-0.4-0.1-0.20.70.6
Stereotopy head waving duration, day 70.50.50.8-0.9-0.9-0.8-0.8-0.9-0.5-0.5-0.70.70.90.8-0.8-0.70.8-0.90.7-0.7-0.4-0.50.60.8
Locomotion velocity, session 80.70.82.0-1.2-1.0-1.4-1.4-1.0-1.2-1.2-0.70.70.90.6-0.6-1.21.0-0.90.3-0.3-0.4-0.20.70.5
Locomotion distance, session 80.50.71.6-1.1-0.8-1.2-1.2-0.7-1.0-1.0-1.00.90.70.6-0.6-1.01.0-0.70.2-0.20.2-0.01.10.1
Degree of sensitization distance3.83.95.82.42.22.42.42.22.42.41.9-1.9-2.2-1.41.42.4-2.42.2-1.31.30.61.3-1.7-1.6
Degree of sensitization stereotypy1.71.82.9-1.7-1.5-1.7-1.7-1.5-1.3-1.3-1.51.51.51.2-1.2-1.41.7-1.60.8-0.8-0.1-0.71.51.1
Conditioned locomotion2.42.74.21.61.61.41.31.61.51.51.9-1.9-1.6-1.81.81.5-1.71.6-1.81.80.71.9-2.0-1.4
Cocaine response after cond. corrected0.20.20.90.10.10.40.50.00.90.9-0.30.30.10.4-0.40.80.0-0.10.5-0.50.2-0.50.50.5
Cocaine response after cond. not corrected0.20.20.70.20.10.40.50.10.80.8-0.40.40.00.5-0.50.80.0-0.10.5-0.50.3-0.60.60.4
Cocaine response before conditioning0.20.30.50.60.60.50.50.70.10.10.5-0.5-0.7-0.50.50.2-0.70.7-0.50.50.10.5-0.6-0.7
Saline control response0.30.40.9-0.6-0.5-0.8-0.7-0.5-1.0-1.0-0.70.70.30.7-0.7-0.80.5-0.30.6-0.6-0.4-0.60.7-0.1
Bone: connectivity density0.60.93.31.00.70.90.80.70.60.61.4-1.4-0.6-0.80.81.0-1.20.7-0.60.6-1.00.7-1.80.1
Bone: cortical apparent density1.01.42.5-1.4-1.4-1.2-1.2-1.4-1.1-1.1-1.01.01.51.0-1.0-1.21.4-1.50.9-0.9-0.5-0.90.91.6
Bone: cortical area0.50.75.30.20.70.30.40.70.60.60.1-0.1-0.8-1.11.10.4-0.00.6-0.90.92.30.80.7-1.3
Bone: cortical porosity1.31.43.31.21.41.01.01.51.01.01.0-1.0-1.6-1.11.10.9-1.41.6-1.11.10.61.2-0.9-1.8
Bone: cortical porosity1.21.32.81.01.30.80.81.30.90.90.9-1.0-1.4-1.31.30.7-1.11.4-1.31.30.91.3-0.9-1.7
Bone: cortical thickness2.64.311.01.52.11.51.72.11.91.91.6-1.6-2.1-2.72.71.7-1.41.9-2.42.43.32.4-0.5-2.4
Bone: cortical thickness0.20.20.7-0.20.2-0.3-0.20.20.10.10.3-0.3-0.3-0.80.8-0.10.00.2-0.60.60.80.40.5-0.7
Bone: cortical tissue density1.42.03.3-1.6-1.6-1.4-1.4-1.7-1.3-1.3-1.21.21.81.3-1.3-1.41.6-1.81.1-1.1-0.8-1.11.01.8
Condit. Reinf. active minus inactive responses0.10.10.40.10.1-0.2-0.20.1-0.1-0.10.1-0.1-0.3-0.10.1-0.1-0.30.30.0-0.0-0.7-0.0-0.3-0.6
Condit. Reinf. active-inactive response ratio0.00.00.50.20.00.00.00.1-0.1-0.10.2-0.2-0.2-0.00.0-0.1-0.30.20.2-0.2-0.7-0.0-0.4-0.2
Condit. Reinf. active responses0.10.10.6-0.3-0.3-0.6-0.6-0.3-0.3-0.30.1-0.10.20.0-0.0-0.40.1-0.10.1-0.1-0.8-0.1-0.2-0.1
Condit. Reinf. inactive responses0.40.51.2-1.0-0.8-1.1-1.1-0.8-0.7-0.7-0.40.40.80.5-0.5-0.80.8-0.70.6-0.6-0.7-0.70.50.5
Incentive salience index mean0.20.20.6-0.4-0.5-0.5-0.6-0.4-0.5-0.5-0.40.40.30.5-0.5-0.60.3-0.30.5-0.5-0.8-0.50.30.0
Condit. Reinf. lever presses1.11.51.9-1.2-1.4-1.1-1.2-1.4-1.1-1.1-1.01.01.41.3-1.3-1.21.2-1.41.3-1.3-1.3-1.20.81.4
Condit. Reinf. active minus inactive responses0.20.20.70.20.40.10.10.40.00.00.0-0.1-0.4-0.40.4-0.1-0.20.4-0.80.80.80.7-0.1-0.7
Condit. Reinf. active-inactive response ratio0.10.10.70.00.1-0.1-0.10.2-0.1-0.10.1-0.1-0.1-0.30.3-0.1-0.10.1-0.80.80.50.7-0.5-0.3
Condit. Reinf. active responses0.40.51.80.70.90.50.50.90.50.50.3-0.3-1.0-0.70.70.3-0.71.0-0.90.90.90.70.1-1.4
Condit. Reinf. inactive responses0.30.31.10.50.70.60.60.70.50.50.1-0.1-0.8-0.40.40.5-0.40.8-0.10.10.90.10.8-1.1
Condit. Reinf. lever presses0.20.30.70.80.70.80.80.70.40.40.1-0.1-0.70.0-0.00.5-0.60.7-0.20.20.40.20.0-0.7
Condit. Reinf. lever reinforcers received0.30.51.60.60.80.50.40.80.40.40.2-0.3-0.9-0.60.60.3-0.60.9-0.80.80.90.70.0-1.3
Conditioned reinforcement - actives0.10.10.30.50.40.40.40.40.40.40.1-0.0-0.50.2-0.20.4-0.60.5-0.30.3-0.30.5-0.5-0.3
Conditioned reinforcement - inactives0.30.40.9-0.4-0.6-0.2-0.2-0.7-0.1-0.1-0.50.60.70.9-0.9-0.10.4-0.70.8-0.8-0.8-0.80.41.0
Conditioned locomotion0.40.51.6-0.8-0.8-0.5-0.5-0.8-0.5-0.5-0.70.70.90.8-0.8-0.50.8-0.90.6-0.6-0.3-0.50.71.3
Patch foraging indifference point 0 sec0.30.51.5-0.7-0.7-0.4-0.4-0.8-0.1-0.1-0.60.60.90.6-0.6-0.21.0-1.00.6-0.60.5-0.81.21.2
Patch foraging indifference point AUC0.30.41.30.30.5-0.00.00.50.10.10.9-0.9-0.5-0.80.80.0-0.70.6-1.01.0-0.20.9-1.2-0.7
Delay disc. indifference point, 0s delay0.40.41.30.30.60.20.30.60.30.30.1-0.1-0.7-0.30.30.2-0.40.7-1.11.11.11.0-0.0-1.1
Delay disc. indifference point, 16s delay0.40.41.30.40.40.2-0.10.40.30.31.1-1.1-0.4-1.01.00.2-0.50.4-0.70.7-0.20.9-1.1-0.3
Delay disc. indifference point, 2s delay0.10.10.2-0.3-0.3-0.2-0.1-0.3-0.1-0.10.0-0.00.4-0.20.2-0.20.4-0.4-0.10.10.40.10.10.5
Delay disc. indifference point, 24s delay1.21.42.91.11.01.10.91.01.21.21.7-1.7-0.9-1.41.41.0-1.00.9-1.11.10.51.3-1.6-0.5
Delay disc. indifference point, 4s delay2.82.94.8-2.0-1.9-2.2-2.1-1.9-2.1-2.1-1.21.21.81.5-1.5-2.21.6-1.71.4-1.4-1.7-1.40.71.5
Delay disc. indifference point, 8s delay0.30.41.1-0.7-0.8-0.8-1.0-0.7-0.6-0.6-0.10.10.80.2-0.2-0.70.6-0.70.5-0.5-0.7-0.3-0.10.8
Indifference point function ln k2.03.45.6-1.6-1.9-1.2-1.3-2.0-1.6-1.6-1.71.82.12.0-2.0-1.41.8-2.12.2-2.2-1.4-2.21.62.4
Indifference point function log k2.03.45.6-1.6-1.9-1.2-1.3-2.0-1.6-1.6-1.71.82.12.0-2.0-1.41.8-2.12.2-2.2-1.4-2.21.62.4
Patch foraging total patch changes 0 sec0.61.22.6-1.1-1.2-0.8-0.8-1.2-0.5-0.5-1.01.01.41.1-1.1-0.51.4-1.41.0-1.00.2-1.21.51.6
Patch foraging total patch changes 12 sec0.20.30.80.20.40.20.20.40.60.60.4-0.4-0.4-0.50.50.4-0.30.4-0.90.90.80.8-0.3-0.4
Patch foraging total patch changes 18 sec0.10.10.4-0.20.0-0.4-0.40.1-0.1-0.10.2-0.2-0.1-0.20.2-0.2-0.00.1-0.60.60.20.3-0.2-0.4
Patch foraging total patch changes 24 sec0.10.10.40.10.1-0.1-0.00.10.40.40.6-0.6-0.0-0.20.20.2-0.30.1-0.30.3-0.40.2-0.5-0.0
Patch foraging total patch changes 6 sec0.71.11.6-1.3-1.2-1.3-1.2-1.2-1.1-1.1-0.70.71.20.9-0.9-1.01.1-1.20.8-0.8-0.8-0.90.81.1
Patch foraging time to switch 0 sec0.00.10.20.10.20.10.10.20.30.3-0.30.3-0.30.3-0.30.4-0.20.30.0-0.00.10.10.2-0.4
Patch foraging water rate 0 sec0.30.71.8-0.9-1.1-0.9-0.9-1.1-1.0-1.0-0.30.31.20.3-0.3-1.01.0-1.20.6-0.6-0.6-0.60.11.4
Patch foraging water rate 12 sec0.30.61.30.80.80.60.60.80.20.21.0-1.0-0.8-1.01.00.3-0.90.8-0.60.60.00.5-1.1-0.8
Patch foraging water rate 18 sec0.10.10.30.30.20.30.30.20.20.20.5-0.5-0.2-0.40.40.3-0.30.2-0.00.0-0.20.2-0.6-0.0
Patch foraging water rate 24 sec0.20.21.10.20.20.10.10.20.10.10.9-0.9-0.1-0.60.60.0-0.30.1-0.50.5-0.10.7-1.10.1
Patch foraging water rate 6 sec0.81.22.2-1.0-1.2-0.7-0.7-1.2-1.1-1.1-0.90.91.30.9-0.9-1.01.3-1.31.3-1.3-0.3-1.31.11.5
Seeking ratio, delayed vs. immediate footshock2.63.25.71.91.72.32.31.62.42.42.0-2.0-1.4-1.91.92.3-1.61.3-1.41.41.41.3-1.1-0.5
Distance traveled before self-admin3.74.87.2-2.5-2.2-2.5-2.5-2.1-2.4-2.4-2.72.72.02.1-2.1-2.42.4-2.01.8-1.8-0.4-1.82.51.3
Distance traveled after self-admin7.08.613.4-3.0-2.9-2.7-2.7-2.9-3.0-3.0-3.53.52.83.1-3.1-2.63.2-2.93.0-3.0-0.8-2.93.72.3
Extensor digitorum longus weight5.722.532.7-5.5-5.1-5.7-5.6-5.0-5.2-5.2-4.84.84.84.7-4.7-5.15.0-4.73.9-3.9-2.8-4.14.23.3
Bone: elastic displacement2.32.74.11.51.61.41.51.51.51.52.0-2.0-1.4-1.81.81.5-1.61.4-2.02.01.11.8-1.8-1.0
Bone: elastic work0.60.81.70.80.80.90.90.71.01.01.3-1.3-0.6-1.21.20.9-0.70.6-0.90.90.80.9-0.9-0.2
Bone: endosteal estimation1.43.24.9-1.7-1.6-1.9-1.9-1.5-2.2-2.2-2.22.21.32.0-2.0-1.91.5-1.21.8-1.8-1.4-1.81.80.5
Bone: endosteal perimeter0.91.94.8-1.3-1.2-1.0-1.0-1.2-1.2-1.2-2.12.11.11.5-1.5-1.01.6-1.21.4-1.40.5-1.42.20.6
Epididymis fat weight1.24.27.4-2.4-2.1-2.3-2.3-2.1-1.9-1.9-2.42.42.11.8-1.8-2.02.6-2.11.8-1.80.2-1.82.71.2
Delta time in closed arm before/after self-admin0.30.30.70.50.40.20.20.4-0.0-0.00.7-0.7-0.5-0.60.60.2-0.60.5-0.50.5-0.50.5-0.8-0.6
Delta time in open arm before/after self-admin0.10.11.50.20.30.40.40.20.30.3-0.10.1-0.1-0.20.20.50.10.1-0.20.21.20.30.2-0.1
Diff in mean of infusions in LGA sessions0.00.10.20.30.10.20.20.1-0.0-0.0-0.10.1-0.10.4-0.40.3-0.30.2-0.00.0-0.5-0.1-0.2-0.1
Delay discount exponential model param0.20.20.60.60.50.60.70.50.50.5-0.10.1-0.60.0-0.00.6-0.50.6-0.20.20.40.10.2-0.5
Extinction: sum of active levers before priming0.10.10.10.30.20.40.30.20.10.10.2-0.2-0.2-0.40.40.3-0.20.2-0.20.20.10.4-0.2-0.2
Active lever presses in extinction session 60.50.51.6-0.5-0.2-0.7-0.7-0.2-0.7-0.7-1.31.2-0.10.8-0.8-0.70.30.10.4-0.4-0.1-0.41.1-1.0
Bone: final force0.20.31.0-0.5-0.2-0.7-0.7-0.1-0.7-0.7-0.60.6-0.1-0.20.2-0.60.50.00.2-0.20.5-0.11.0-0.9
Bone: final moment0.20.21.1-0.4-0.0-0.6-0.6-0.0-0.6-0.6-0.60.5-0.2-0.20.2-0.50.40.20.1-0.10.6-0.11.0-1.0
Food consumed during 24 hour testing period3.75.16.5-2.5-2.3-2.5-2.5-2.3-2.5-2.5-2.42.42.12.3-2.3-2.52.3-2.12.2-2.2-1.5-2.12.11.4
Glucose0.10.20.7-0.5-0.3-0.6-0.6-0.2-0.5-0.5-0.80.80.10.5-0.5-0.40.4-0.10.1-0.10.1-0.30.8-0.5
Heart weight0.71.22.1-1.2-1.3-1.2-1.1-1.3-1.1-1.1-0.40.41.40.6-0.6-1.11.2-1.41.1-1.1-0.9-0.90.51.4
Delay discount hyperbolic model param0.20.30.70.70.60.80.80.60.60.60.1-0.1-0.6-0.10.10.7-0.60.6-0.20.20.40.20.1-0.5
Intermittent access intake day 1-15 change0.20.31.3-0.6-0.6-0.8-0.8-0.6-0.9-0.9-0.20.20.50.3-0.3-0.90.4-0.40.3-0.3-1.1-0.3-0.10.1
Intermittent access intake escalation0.20.31.1-0.6-0.7-0.8-0.8-0.6-0.9-0.9-0.20.20.50.3-0.3-0.90.4-0.50.3-0.3-1.1-0.4-0.00.2
Intermittent access intake escalation 20.20.20.6-0.4-0.4-0.6-0.6-0.4-0.7-0.7-0.10.10.30.0-0.0-0.70.3-0.30.2-0.2-0.8-0.2-0.1-0.0
Intermitt. access day 1 inactive lever presses0.20.93.4-0.9-1.1-1.1-1.1-1.0-1.0-1.0-0.50.50.90.7-0.7-1.00.7-0.81.3-1.3-1.9-1.00.40.4
Intermitt. access day 15 inactive lever presses0.10.22.40.3-0.1-0.1-0.1-0.0-0.1-0.10.1-0.1-0.10.2-0.2-0.1-0.50.20.1-0.1-1.6-0.1-0.6-0.5
Intermitt. access escalation Index0.20.31.20.3-0.10.50.5-0.10.60.60.2-0.10.10.2-0.20.6-0.2-0.01.0-1.0-1.1-0.90.20.2
Intermittent access day 1 total infusions0.10.11.4-0.1-0.3-0.2-0.2-0.2-0.1-0.10.4-0.30.20.1-0.1-0.1-0.1-0.10.0-0.0-1.2-0.1-0.50.2
Intermittent access day 15 total infusions0.20.33.20.1-0.1-0.3-0.3-0.0-0.4-0.40.7-0.7-0.1-0.20.2-0.4-0.50.2-0.40.4-1.80.2-1.1-0.4
Intermittent access terminal intake (last 3 days)0.50.76.4-0.5-0.8-1.1-1.1-0.6-1.1-1.10.1-0.10.40.4-0.4-1.1-0.0-0.20.1-0.1-2.5-0.2-0.7-0.2
Intermittent access total infusions0.30.45.00.1-0.3-0.4-0.4-0.2-0.4-0.40.7-0.70.1-0.00.0-0.4-0.50.1-0.20.2-2.20.1-1.1-0.3
Intermittent access day 1 locomotion0.10.10.2-0.3-0.2-0.4-0.4-0.2-0.3-0.3-0.20.20.20.2-0.2-0.30.2-0.2-0.40.40.20.30.20.3
Intermittent access day 15 total locomotion0.30.50.8-0.8-0.7-0.7-0.7-0.7-0.7-0.7-0.90.90.70.9-0.9-0.70.7-0.70.3-0.3-0.4-0.40.60.9
Intermittent access total locomotion0.30.30.6-0.6-0.6-0.6-0.6-0.6-0.6-0.6-0.60.60.60.7-0.7-0.60.5-0.60.1-0.1-0.3-0.30.50.8
Intermittent access standard deviation0.20.51.9-0.6-0.7-0.9-0.9-0.7-1.0-1.0-0.30.30.50.4-0.4-1.00.4-0.40.4-0.4-1.4-0.50.2-0.1
Left kidney weight0.20.81.6-1.1-1.0-0.9-0.8-1.0-0.8-0.8-0.90.91.10.8-0.8-0.71.3-1.20.5-0.50.5-0.51.11.1
Right kidney weight0.31.32.7-1.5-1.1-1.3-1.2-1.1-1.1-1.1-1.41.41.20.9-0.9-0.91.6-1.30.6-0.61.0-0.61.60.7
Cocaine induced anxiety0.30.41.00.50.70.40.40.70.40.40.1-0.1-0.8-0.30.30.4-0.60.8-0.90.90.70.9-0.3-1.0
Post-drug Anxiety0.70.82.10.91.00.60.61.10.60.60.5-0.5-1.2-0.60.60.6-1.01.2-0.90.90.41.0-0.7-1.5
Baseline Anxiety0.40.41.0-0.6-0.7-0.6-0.6-0.7-0.6-0.6-0.30.30.70.5-0.5-0.60.5-0.70.9-0.9-1.0-0.90.30.6
Tail length0.20.71.9-1.0-0.8-0.7-0.6-0.8-0.6-0.6-0.80.70.90.6-0.6-0.61.1-1.00.9-0.90.5-0.91.40.9
Length with tail0.31.55.0-1.4-1.1-1.2-1.1-1.1-1.0-1.0-1.61.61.01.0-1.0-1.01.5-1.11.1-1.10.6-1.32.20.5
Length without tail0.30.92.9-1.2-0.8-1.2-1.0-0.8-0.9-0.9-1.41.40.70.6-0.6-0.81.3-0.80.5-0.50.7-0.71.70.1
Times rat made contact with spout2.22.56.6-1.5-1.3-1.1-1.2-1.4-1.4-1.4-2.32.31.31.6-1.6-1.31.8-1.41.7-1.70.5-1.82.60.8
Lifetime Intake0.30.44.00.1-0.2-0.3-0.3-0.1-0.3-0.30.8-0.8-0.0-0.20.2-0.3-0.50.2-0.30.3-2.00.2-1.1-0.3
Liver weight, left0.40.71.3-0.9-0.7-1.1-1.1-0.6-0.7-0.7-1.21.20.40.9-0.9-0.70.7-0.40.7-0.7-0.5-0.71.2-0.4
Liver weight, right4.27.311.1-2.7-2.6-2.5-2.6-2.6-2.4-2.4-3.33.32.43.1-3.1-2.42.7-2.42.9-2.9-1.5-3.03.31.7
Locomotor activity0.30.50.9-0.6-0.6-0.7-0.8-0.6-1.0-1.0-0.90.90.50.8-0.8-0.80.7-0.50.6-0.6-0.2-0.60.90.0
Locomotor testing distance0.20.41.2-0.5-0.3-0.6-0.6-0.3-0.6-0.6-1.01.00.20.7-0.7-0.50.6-0.20.3-0.30.5-0.41.1-0.4
Locomotor testing rearing0.40.82.90.91.10.90.81.20.80.80.1-0.2-1.3-0.40.40.7-0.91.2-0.70.71.10.70.3-1.7
Locomotion in novel chamber0.00.10.5-0.1-0.0-0.1-0.1-0.0-0.2-0.2-0.40.40.0-0.00.0-0.10.3-0.1-0.20.20.70.00.5-0.2
Locomotion in novel chamber post-restriction0.30.51.30.70.70.30.50.70.30.30.9-0.9-0.8-0.80.80.4-1.00.9-0.50.5-0.60.5-1.2-0.8
Fecal boli incidents, locomotor time 10.40.53.20.60.7-0.0-0.00.80.20.20.4-0.4-1.1-0.40.40.1-1.11.2-0.20.2-1.00.4-0.8-1.8
Change in fecal boli incidents, locomotor task3.63.68.91.81.72.22.01.62.12.11.7-1.7-1.4-2.32.32.1-1.11.3-2.12.13.02.0-0.7-1.0
Time >=10cm from walls, locomotor time 10.70.71.21.00.91.00.70.91.11.10.7-0.7-0.9-1.01.01.1-0.80.9-0.50.50.60.8-0.5-1.0
Bouts of movement, locomotor time 10.10.10.7-0.2-0.2-0.3-0.1-0.2-0.2-0.20.4-0.40.2-0.10.1-0.1-0.1-0.2-0.20.2-0.80.1-0.60.6
Total resting periods, locomotor time 10.10.10.9-0.2-0.2-0.3-0.2-0.2-0.2-0.20.4-0.40.3-0.10.1-0.2-0.1-0.2-0.20.2-0.90.0-0.60.7
Rest time, locomotor task time 10.60.73.5-0.7-0.6-1.2-1.4-0.5-1.2-1.2-0.60.60.30.8-0.8-1.30.1-0.10.3-0.3-1.9-0.5-0.2-0.4
Distance moved, locomotor task time 10.30.52.40.30.20.91.10.10.80.8-0.40.40.1-0.00.00.90.4-0.20.6-0.61.5-0.61.40.6
Vertical activity count, locomotor time 10.41.13.2-0.6-0.80.10.2-0.90.10.1-1.11.01.00.7-0.70.41.2-1.21.6-1.60.8-1.51.81.4
Time >=10cm from walls, locomotor time 21.52.23.51.51.61.51.11.61.51.51.0-1.1-1.6-1.61.61.5-1.31.6-1.61.61.71.6-0.9-1.9
Bouts of movement, locomotor time 20.10.20.7-0.3-0.3-0.5-0.6-0.3-0.4-0.40.4-0.30.40.1-0.1-0.4-0.0-0.3-0.30.3-0.80.2-0.70.5
Total resting periods, locomotor time 20.20.31.2-0.5-0.5-0.8-0.8-0.5-0.5-0.50.2-0.20.60.3-0.3-0.60.1-0.5-0.10.1-1.10.0-0.70.7
Rest time, locomotor task time 20.60.86.3-0.5-0.5-1.1-1.1-0.4-1.2-1.2-0.20.20.20.9-0.9-1.4-0.2-0.10.5-0.5-2.5-0.5-0.70.1
Distance moved, locomotor task time 20.60.72.20.90.81.31.40.81.31.30.2-0.2-0.7-0.60.61.5-0.40.6-0.10.11.40.10.4-0.4
Vertical activity count, locomotor time 21.52.04.8-1.2-1.3-0.9-0.9-1.3-0.9-0.9-1.61.61.31.5-1.5-0.61.3-1.32.2-2.2-1.0-2.21.61.2
Light reinforcement 10.20.61.3-1.0-0.8-0.9-0.8-0.8-0.4-0.4-0.90.90.80.7-0.7-0.61.0-0.90.5-0.50.4-0.41.10.5
Light reinforcement 22.33.58.3-2.0-1.8-1.3-1.1-1.9-1.1-1.1-2.12.12.11.7-1.7-1.12.6-2.31.9-1.91.2-1.82.92.3
Bone: marrow area1.63.45.1-1.8-1.7-2.0-1.9-1.6-2.3-2.3-2.22.21.32.1-2.1-2.01.5-1.31.9-1.9-1.6-1.91.80.6
Bone: maximum diameter0.20.32.4-0.4-0.0-0.3-0.1-0.0-0.1-0.1-0.80.7-0.0-0.10.1-0.10.6-0.10.1-0.11.5-0.11.2-0.6
Bone: maximum force0.30.61.5-0.8-0.5-1.1-1.0-0.4-1.1-1.1-1.11.10.10.4-0.4-0.90.6-0.10.6-0.6-0.1-0.51.2-0.8
Bone: maximum moment0.30.51.2-0.7-0.3-0.9-0.9-0.2-1.0-0.9-1.01.0-0.10.4-0.4-0.80.40.10.4-0.40.0-0.41.1-1.0
Mean time between licks in bursts0.92.34.6-1.4-1.5-1.5-1.4-1.5-1.7-1.7-1.31.31.41.6-1.6-1.71.1-1.31.7-1.7-2.1-1.50.61.4
Mean num. licks in bursts0.10.10.20.40.40.50.40.40.10.10.1-0.1-0.5-0.30.30.2-0.30.5-0.20.20.40.10.1-0.5
Cd content in liver1.11.22.1-1.1-0.9-1.5-1.4-0.8-1.5-1.5-1.31.30.61.3-1.3-1.50.7-0.50.6-0.6-1.3-0.90.7-0.2
Co content in liver0.80.92.3-0.8-0.6-0.7-0.6-0.7-0.8-0.8-1.51.50.51.1-1.1-0.80.9-0.61.2-1.2-0.0-1.11.50.2
Cu content in liver0.30.40.70.70.80.80.80.80.70.70.0-0.1-0.7-0.30.30.7-0.60.7-0.50.50.90.4-0.2-0.7
Fe content in liver0.91.02.21.01.20.91.01.20.90.90.4-0.5-1.3-0.80.80.9-0.91.2-1.01.01.51.2-0.2-1.5
K content in liver0.50.51.10.90.71.11.00.60.90.90.9-0.9-0.5-0.70.70.9-0.60.5-0.30.30.40.4-0.6-0.0
Mg content in liver0.20.20.60.60.30.80.70.30.60.60.3-0.3-0.1-0.10.10.6-0.40.1-0.20.20.20.0-0.30.3
Mn content in liver0.10.10.2-0.2-0.3-0.2-0.3-0.3-0.3-0.3-0.00.00.40.1-0.1-0.30.2-0.40.2-0.2-0.40.1-0.20.4
Na content in liver0.20.21.0-0.4-0.3-0.2-0.1-0.4-0.2-0.2-0.30.30.5-0.10.1-0.20.7-0.60.2-0.21.00.00.60.5
Rb content in liver2.42.85.01.82.01.71.72.01.51.51.0-1.1-2.1-1.31.31.5-1.82.1-1.71.71.51.5-0.9-2.2
Se content in liver0.40.51.20.70.80.60.60.80.60.60.4-0.4-0.8-0.80.80.6-0.50.7-0.70.71.10.9-0.4-0.9
Sr content in liver0.30.31.50.50.00.40.40.00.40.40.8-0.80.0-0.50.50.4-0.50.0-0.10.1-1.20.2-1.10.2
Zn content in liver0.10.10.30.1-0.20.20.2-0.20.00.0-0.20.20.20.4-0.40.00.0-0.20.4-0.4-0.5-0.5-0.20.6
Bone: minimum diameter0.30.52.0-0.6-0.4-0.4-0.4-0.4-0.5-0.5-1.21.20.30.8-0.8-0.50.7-0.40.7-0.70.5-0.61.4-0.0
Time in familiar zone, hab. session 10.20.20.60.20.00.20.30.00.30.3-0.30.3-0.10.6-0.60.1-0.20.10.8-0.8-0.7-0.50.30.0
Time in novel zone, hab. session 10.10.10.3-0.5-0.4-0.5-0.5-0.4-0.4-0.4-0.10.10.50.0-0.0-0.40.5-0.5-0.30.30.3-0.10.20.4
Total zone transitions, hab. session 10.10.10.5-0.2-0.1-0.3-0.2-0.10.10.10.5-0.50.1-0.50.5-0.10.0-0.1-0.50.50.00.7-0.50.2
Total locomotion distance, hab. session 10.10.10.7-0.00.1-0.10.00.10.30.30.3-0.4-0.0-0.50.50.0-0.00.0-0.70.70.50.8-0.2-0.0
Locomotion velocity, hab. session 10.10.10.2-0.3-0.2-0.3-0.2-0.2-0.1-0.10.1-0.10.3-0.20.2-0.20.3-0.3-0.40.40.30.50.00.3
Time in familiar zone, hab. session 20.20.20.60.50.30.70.70.30.50.5-0.10.1-0.30.4-0.40.6-0.40.30.5-0.5-0.2-0.60.20.1
Time in novel zone, hab. session 20.40.41.00.30.40.10.10.50.20.20.8-0.8-0.5-0.80.80.1-0.60.6-0.90.9-0.10.9-1.0-0.7
Total zone transitions, hab. session 20.20.20.7-0.7-0.5-0.8-0.8-0.5-0.3-0.3-0.50.50.50.5-0.5-0.20.5-0.50.0-0.0-0.00.10.40.3
Total locomotion distance, hab. session 20.00.00.3-0.10.1-0.2-0.10.10.10.10.0-0.0-0.1-0.10.10.1-0.00.1-0.40.40.30.6-0.1-0.1
Locomotion velocity, hab. session 20.00.10.3-0.2-0.0-0.3-0.2-0.00.10.1-0.10.10.1-0.10.10.10.2-0.1-0.40.40.50.60.10.1
Novel to familiar place preference ratio2.22.43.51.61.61.41.31.61.41.41.6-1.6-1.5-1.51.51.3-1.71.6-1.91.90.71.7-1.8-1.3
Novelty place preference1.82.03.01.41.41.31.21.41.21.21.6-1.6-1.3-1.41.41.2-1.51.4-1.71.70.61.6-1.7-1.1
Time in novel zone, NPP test1.41.52.31.31.31.11.01.31.11.11.3-1.3-1.2-1.21.21.1-1.31.3-1.51.50.51.4-1.5-1.0
Total zone transitions, NPP test0.10.10.5-0.00.2-0.4-0.20.30.30.30.2-0.2-0.4-0.20.20.3-0.40.4-0.60.6-0.20.7-0.5-0.6
Total locomotion distance, NPP test0.10.20.50.10.4-0.00.10.40.60.60.0-0.0-0.4-0.20.20.5-0.30.4-0.60.60.40.7-0.1-0.6
Locomotion velocity, NPP test0.50.71.30.60.90.40.60.91.11.10.6-0.6-0.9-0.70.71.0-0.80.9-1.11.10.61.2-0.7-0.9
Intraocular pressure0.60.91.9-1.2-1.0-1.4-1.3-1.0-1.1-1.1-0.90.91.01.0-1.0-1.10.9-0.90.6-0.6-0.8-0.60.60.6
Delta distance traveled before/after self-admin0.10.10.3-0.1-0.20.10.0-0.2-0.2-0.2-0.20.20.30.3-0.30.00.3-0.30.3-0.30.1-0.30.40.5
Delta ambulatory time before/after self-admin0.10.20.40.50.30.60.60.20.40.40.5-0.5-0.0-0.40.40.6-0.2-0.0-0.30.30.60.3-0.20.2
Parametrial fat weight1.84.36.9-2.5-2.1-2.4-2.3-2.1-2.4-2.4-2.42.32.01.5-1.5-2.32.5-2.11.9-1.90.1-1.72.61.2
Pavlov. Cond. lever latency1.11.43.10.91.30.91.01.21.01.00.9-0.9-1.2-1.31.31.1-0.91.1-1.51.51.81.4-0.5-1.3
Pavlov. Cond. magazine entry latency2.43.17.5-1.5-1.9-1.5-1.6-1.9-1.8-1.8-1.01.01.91.8-1.8-1.81.3-1.82.0-2.0-2.7-2.00.42.0
Pavlov. Cond. change in total contacts4.34.55.5-2.1-2.4-2.2-2.3-2.3-2.1-2.1-1.91.92.22.1-2.1-2.22.0-2.22.3-2.3-2.3-2.11.41.9
Pavlov. Cond. index score3.74.77.9-2.0-2.4-2.0-2.1-2.4-2.1-2.1-1.61.72.32.3-2.3-2.21.9-2.22.4-2.4-2.8-2.41.02.3
Pavlov. Cond. latency score2.43.16.1-1.6-1.9-1.6-1.7-1.9-1.8-1.8-1.31.41.81.8-1.8-1.81.4-1.72.0-2.0-2.5-1.90.81.6
Pavlov. Cond. lever contacts2.53.05.8-1.5-1.9-1.4-1.6-1.9-1.6-1.6-1.11.11.91.8-1.8-1.71.4-1.82.0-2.0-2.4-1.90.72.1
Pavlov. Cond. magazine entry number4.65.99.12.32.72.22.32.72.42.41.6-1.7-2.7-2.42.42.4-2.12.6-2.82.83.02.7-1.0-2.7
Pavlov. Cond. intertrial magazine entries1.01.22.10.80.90.80.90.91.21.21.3-1.3-0.8-1.41.41.1-0.70.7-1.41.41.41.1-0.7-0.7
Pavlov. Cond. lever-magazine prob. diff.5.06.18.8-2.3-2.7-2.3-2.4-2.7-2.4-2.4-2.02.02.72.6-2.6-2.52.2-2.62.8-2.8-3.0-2.71.42.6
Pavlov. Cond. response bias5.16.49.3-2.4-2.9-2.3-2.4-2.9-2.5-2.5-1.71.72.92.5-2.5-2.52.3-2.82.8-2.8-3.0-2.71.13.0
Pavlov. Cond. lever latency0.50.73.2-0.9-1.0-1.2-1.1-0.9-0.7-0.70.1-0.10.90.3-0.3-0.80.5-0.80.6-0.6-1.8-0.5-0.61.0
Pavlov. Cond. magazine entry latency0.40.51.0-0.5-0.6-0.3-0.4-0.7-0.6-0.6-0.80.80.61.0-1.0-0.60.6-0.61.0-1.0-0.5-0.90.70.7
Pavlov. Cond. change in total contacts0.50.92.61.01.11.11.01.10.70.70.3-0.3-1.1-0.60.60.8-0.71.1-1.01.01.60.9-0.1-1.3
Pavlov. Cond. index score0.10.20.70.00.00.30.2-0.0-0.1-0.1-0.70.70.00.6-0.6-0.10.3-0.10.3-0.30.7-0.30.8-0.1
Pavlov. Cond. latency score0.10.10.60.10.00.30.20.0-0.1-0.1-0.70.6-0.00.5-0.5-0.10.2-0.00.2-0.20.7-0.30.8-0.1
Pavlov. Cond. lever contacts0.50.73.60.91.01.21.20.90.80.8-0.10.1-0.9-0.30.30.9-0.50.8-0.60.61.90.50.7-1.0
Pavlov. Cond. magazine entry number0.10.10.4-0.00.0-0.1-0.10.00.10.10.6-0.60.0-0.50.50.1-0.2-0.0-0.30.3-0.30.3-0.60.2
Pavlov. Cond. intertrial magazine entries0.30.41.10.50.50.40.40.50.70.71.0-1.0-0.4-1.01.00.5-0.60.4-0.60.6-0.10.6-0.8-0.2
Pavlov. Cond. lever-magazine prob. diff.0.20.20.9-0.2-0.20.10.0-0.2-0.3-0.3-0.80.80.20.7-0.7-0.20.5-0.30.4-0.40.6-0.51.00.1
Pavlov. Cond. response bias0.20.31.90.50.60.80.70.50.40.4-0.40.4-0.50.1-0.10.5-0.10.4-0.20.21.40.20.7-0.6
Time in closed arm before self-admin0.40.61.9-0.6-0.8-0.4-0.5-0.8-0.7-0.7-0.40.40.90.9-0.9-0.40.6-0.90.8-0.8-0.9-0.80.21.4
Time in closed arm after self-admin0.40.41.9-0.2-0.6-0.1-0.1-0.6-0.5-0.5-0.20.20.60.8-0.8-0.10.2-0.51.1-1.1-1.4-1.00.00.9
Time in open arm before self-admin0.10.10.7-0.3-0.2-0.3-0.3-0.2-0.1-0.1-0.50.50.10.4-0.4-0.40.4-0.20.4-0.40.2-0.50.9-0.1
Time in open arm after self-admin0.20.21.7-0.4-0.2-0.3-0.3-0.2-0.1-0.1-0.70.70.20.0-0.0-0.40.6-0.3-0.10.11.30.10.9-0.1
Bone: periosteal estimation0.40.82.7-1.0-0.6-1.0-0.9-0.6-1.0-1.0-1.41.40.40.7-0.7-0.91.0-0.50.8-0.80.5-0.81.7-0.4
Bone: periosteal perimeter0.30.53.5-0.5-0.1-0.2-0.1-0.1-0.1-0.1-1.11.10.10.2-0.2-0.10.8-0.20.2-0.21.9-0.21.7-0.5
Bone: post-yield work1.42.13.3-1.1-1.1-1.4-1.4-1.0-1.7-1.7-1.81.80.71.8-1.8-1.50.9-0.61.7-1.7-1.8-1.61.4-0.1
Progressive ratio test 1 active lever presses0.20.30.8-0.6-0.4-0.9-0.9-0.4-0.8-0.8-0.10.10.30.3-0.3-0.80.2-0.2-0.30.3-0.70.2-0.1-0.0
Progressive ratio test 1 breakpoint0.20.20.8-0.5-0.4-0.9-0.9-0.3-0.8-0.8-0.10.10.20.3-0.3-0.80.2-0.2-0.30.3-0.70.2-0.1-0.1
Progressive ratio test 1 inactive lever presses0.20.30.80.60.40.50.50.50.60.60.9-0.9-0.4-0.50.50.6-0.70.5-0.50.5-0.50.5-0.8-0.2
Progressive ratio test 2 active lever presses0.20.21.0-0.1-0.1-0.2-0.2-0.1-0.2-0.20.7-0.70.1-0.40.4-0.2-0.2-0.0-0.70.7-0.50.7-1.00.2
Progressive ratio test 2 breakpoint0.10.20.7-0.2-0.2-0.3-0.3-0.2-0.3-0.30.5-0.50.2-0.30.3-0.3-0.0-0.2-0.50.5-0.60.5-0.80.3
Progressive ratio test 2 inactive lever presses0.10.22.80.0-0.2-0.3-0.3-0.2-0.3-0.30.3-0.20.10.2-0.2-0.3-0.30.1-0.00.0-1.7-0.0-0.7-0.2
Incentive Sensitization - Responses0.10.10.90.0-0.3-0.0-0.0-0.3-0.0-0.00.2-0.20.30.1-0.1-0.0-0.0-0.30.0-0.0-1.0-0.0-0.70.4
Incentive Sensitization - Breakpoint0.10.11.1-0.1-0.4-0.1-0.1-0.4-0.1-0.10.1-0.10.50.2-0.2-0.10.1-0.40.2-0.2-1.0-0.2-0.50.6
Sum of active levers in priming session hrs 5-60.80.71.5-0.7-0.7-0.6-0.7-0.7-0.7-0.7-1.21.20.71.2-1.2-0.50.8-0.70.8-0.8-0.2-1.01.20.5
Progressive ratio0.50.71.90.71.00.40.61.00.50.50.9-0.9-1.2-0.80.80.6-1.11.2-0.80.80.10.7-1.0-1.4
Food seeking constrained by brief footshock0.10.10.70.2-0.00.20.3-0.0-0.2-0.2-0.10.10.10.4-0.4-0.1-0.2-0.00.6-0.6-0.9-0.4-0.50.4
Seeking ratio, punishment vs. effort0.40.52.1-0.3-0.80.0-0.2-0.8-0.4-0.4-0.70.71.00.8-0.8-0.40.8-1.00.8-0.8-0.3-0.70.51.5
Retroperitoneal fat weight0.83.46.3-2.4-2.1-2.5-2.4-2.1-2.1-2.1-1.61.62.01.3-1.3-2.02.2-2.01.4-1.4-0.8-1.51.51.3
Reaction time number correct1.73.24.11.92.01.92.02.01.91.91.6-1.6-2.0-2.02.01.8-1.71.9-1.51.51.91.3-0.7-1.8
Reaction time mean minus median5.112.714.6-3.7-3.8-3.7-3.6-3.8-3.8-3.8-3.53.53.73.8-3.8-3.63.3-3.63.5-3.5-3.5-3.62.53.2
Reaction time mean minus median AUC4.511.514.7-3.6-3.6-3.7-3.6-3.6-3.8-3.8-3.13.13.53.4-3.4-3.73.1-3.33.3-3.3-3.5-3.42.22.9
Reaction time num false alarms5.27.38.82.62.92.52.52.92.92.92.4-2.4-3.0-2.92.92.8-2.62.9-2.72.72.42.7-1.8-2.9
Reaction time num false alarms AUC4.36.78.02.52.82.52.52.82.82.82.3-2.3-2.8-2.82.82.7-2.32.7-2.52.52.72.6-1.6-2.7
Reaction time trials correct on left1.73.24.11.92.01.92.02.01.91.91.6-1.6-2.0-2.02.01.8-1.71.9-1.51.51.91.3-0.7-1.8
Reaction time trials on left1.73.24.21.92.01.91.92.01.91.91.6-1.6-2.0-2.02.01.8-1.72.0-1.51.51.91.3-0.6-1.9
Reaction time mean1.72.74.3-1.5-1.6-1.7-1.6-1.6-1.7-1.7-1.91.91.42.1-2.1-1.61.3-1.31.8-1.8-2.0-1.81.21.0
Reaction time mean AUC1.42.34.0-1.3-1.5-1.5-1.4-1.4-1.5-1.5-1.71.71.31.9-1.9-1.41.1-1.21.7-1.7-2.0-1.71.01.0
Median of all reaction times0.40.61.5-0.5-0.6-0.7-0.6-0.6-0.7-0.7-1.01.00.41.2-1.2-0.60.4-0.40.9-0.9-1.2-0.90.50.1
Reaction time omissions0.60.91.6-1.0-0.8-1.3-1.1-0.8-0.8-0.8-1.21.20.61.1-1.1-0.80.7-0.61.0-1.0-0.9-0.90.90.1
Reaction time false alarm rate1.52.12.91.31.51.31.31.51.61.61.3-1.3-1.4-1.61.61.6-1.21.4-1.51.51.61.7-1.0-1.4
Reaction time premature initiation rate0.10.10.9-0.3-0.4-0.4-0.3-0.40.00.00.2-0.20.50.4-0.4-0.00.0-0.40.0-0.0-0.9-0.1-0.70.8
Reaction time premature initiations0.10.20.50.40.40.30.40.40.70.70.7-0.7-0.3-0.30.30.6-0.50.3-0.40.4-0.20.3-0.70.1
Std. dev. reaction times3.76.98.1-2.7-2.7-2.8-2.7-2.7-2.9-2.9-2.72.72.52.8-2.8-2.72.3-2.42.7-2.7-2.6-2.82.01.9
Reaction time trials completed1.73.24.21.92.01.91.92.01.91.91.6-1.6-2.0-2.02.01.8-1.72.0-1.51.51.91.3-0.6-1.9
Reaction time trials AUC1.52.83.81.71.91.81.81.91.81.81.4-1.4-1.9-1.91.91.7-1.61.9-1.41.41.91.2-0.5-1.8
Run reversals in cocaine runway, females5.45.47.0-2.5-2.4-2.2-2.2-2.5-2.3-2.3-2.52.52.52.2-2.2-2.22.6-2.52.4-2.4-0.7-2.32.52.2
Run reversals in cocaine runway, males1.41.43.4-0.8-1.0-1.0-1.3-1.0-1.5-1.5-1.21.20.81.5-1.5-1.50.7-0.71.2-1.2-1.8-1.20.50.3
Latency to leave start box in cocaine runway0.80.92.4-0.6-1.0-0.4-0.5-1.0-0.5-0.5-0.60.61.10.7-0.7-0.60.9-1.01.5-1.5-1.0-1.31.21.2
Latency to leave start box in cocaine runway, F0.30.41.2-0.4-0.6-0.4-0.4-0.6-0.2-0.2-0.30.30.60.4-0.4-0.40.4-0.51.0-1.0-1.1-1.00.70.6
Latency to leave start box in cocaine runway, M0.40.40.9-0.3-0.6-0.1-0.3-0.6-0.4-0.4-0.60.60.70.5-0.5-0.40.7-0.71.0-1.0-0.2-0.80.90.8
Std. dev. time between licks in bursts0.20.30.60.50.40.40.50.40.40.40.8-0.7-0.3-0.70.70.2-0.50.4-0.60.60.30.7-0.7-0.1
Total sessions with >9 infusions0.70.91.20.81.00.70.71.00.80.81.0-1.0-1.1-1.01.00.8-0.91.0-1.11.10.81.0-0.5-0.8
Short access day 1 total inactive lever presses0.60.81.40.70.71.01.00.61.11.11.2-1.2-0.4-1.21.21.1-0.50.4-0.60.61.10.8-0.70.4
Short access day 10 total inactive lever presses0.00.10.10.30.20.30.30.20.20.20.1-0.1-0.3-0.30.30.2-0.20.30.1-0.10.10.1-0.0-0.2
Short access day 1 total infusions0.10.10.2-0.4-0.3-0.3-0.3-0.3-0.2-0.2-0.00.00.3-0.00.0-0.20.4-0.4-0.00.00.4-0.10.40.4
Short access day 10 total infusions0.10.11.00.20.1-0.1-0.10.20.10.10.6-0.5-0.3-0.20.20.1-0.50.4-0.30.3-1.00.1-0.5-0.4
Short access total infusions0.10.20.60.10.1-0.1-0.10.20.00.00.8-0.8-0.3-0.60.60.0-0.40.3-0.50.5-0.60.4-0.6-0.3
Short access day 1 locomotion0.30.43.10.00.30.20.20.30.30.30.6-0.5-0.1-0.80.80.30.10.0-1.01.01.80.90.00.1
Short access day 10 total locomotion0.10.20.60.10.5-0.1-0.10.50.10.1-0.00.0-0.7-0.30.30.1-0.30.6-0.80.80.80.60.2-0.8
Short access total locomotion0.10.21.4-0.20.2-0.2-0.20.1-0.0-0.00.3-0.3-0.1-0.50.5-0.00.20.1-0.70.71.20.60.30.1
One hour access (0.3 mA shock)0.70.86.0-0.4-0.9-0.4-0.4-0.9-0.5-0.5-0.40.40.91.1-1.1-0.50.2-0.80.9-0.9-2.5-0.9-0.30.8
Compulsive drug intake0.20.21.40.1-0.30.20.2-0.30.20.2-0.10.20.30.5-0.50.2-0.1-0.20.7-0.7-1.2-0.9-0.00.2
One hour access (shock baseline)0.30.52.10.60.30.30.30.30.30.31.0-0.9-0.4-0.50.50.3-0.90.5-0.60.6-1.40.7-1.5-0.4
Social response proportion0.00.10.20.20.20.10.10.20.10.1-0.40.4-0.30.2-0.20.1-0.20.3-0.10.1-0.10.00.0-0.5
Social responses0.40.51.4-0.6-0.5-0.5-0.5-0.6-0.5-0.5-1.11.10.50.8-0.8-0.40.7-0.50.8-0.80.0-0.81.20.3
Social time0.50.72.80.90.90.40.41.00.30.30.5-0.5-1.3-0.40.40.2-1.31.4-0.40.4-0.80.5-0.8-1.7
Soleus weight0.30.82.1-1.3-1.1-1.1-1.0-1.1-0.6-0.6-0.50.51.30.7-0.7-0.61.3-1.40.2-0.20.4-0.30.91.4
Bone: stiffness0.50.81.8-1.0-0.5-1.3-1.3-0.5-1.1-1.1-1.31.30.20.6-0.6-0.90.7-0.20.7-0.7-0.2-0.61.3-0.9
Tibialis anterior weight6.221.129.0-5.3-5.0-5.4-5.3-5.0-5.0-5.0-4.64.64.94.5-4.5-5.05.0-4.83.7-3.7-2.6-3.84.03.6
Time to tail flick, vehicle, before self-admin0.40.42.80.30.6-0.1-0.10.7-0.2-0.2-0.0-0.0-0.9-0.60.6-0.2-0.61.0-0.60.60.10.6-0.2-1.7
Time to tail flick, vehicle, after self-admin4.25.69.22.42.51.92.02.61.71.72.2-2.2-2.6-2.12.12.0-2.72.7-3.03.01.02.8-2.8-2.5
Time to tail flick, test, before self-admin0.91.02.2-0.9-1.1-0.8-0.9-1.1-0.8-0.8-0.90.91.31.2-1.2-0.71.0-1.20.8-0.8-0.8-0.80.31.5
Time to tail flick, test, after self-admin1.11.12.41.00.90.80.91.01.31.31.4-1.4-0.9-1.01.00.8-1.21.0-1.11.1-0.11.1-1.6-0.5
Delta time to tail flick, vehicle, before/after SA5.55.37.42.42.32.32.42.32.22.22.5-2.5-2.2-2.02.02.4-2.52.2-2.62.61.22.5-2.7-1.5
Delta time to tail flick, test, before/after SA0.90.91.50.80.90.60.70.91.01.01.2-1.2-0.9-1.11.10.6-1.00.9-1.11.10.41.1-0.9-0.8
Tibia length0.10.21.30.20.50.00.10.5-0.1-0.10.0-0.1-0.7-0.50.5-0.0-0.30.6-0.60.60.80.5-0.1-1.1
Ambulatory time before self-admin3.04.57.2-2.4-2.0-2.2-2.2-2.0-2.3-2.3-2.72.71.92.2-2.2-2.22.3-1.91.9-1.9-0.5-1.92.51.3
Ambulatory time after self-admin3.54.26.1-2.1-2.0-1.8-1.9-2.0-2.2-2.2-2.42.42.02.2-2.2-1.82.2-2.12.0-2.0-0.6-2.02.51.6
Bone: tissue strength0.20.21.10.50.60.20.20.6-0.0-0.00.1-0.1-0.8-0.30.30.1-0.60.8-0.30.3-0.10.5-0.6-1.0
Total heroin consumption0.60.71.7-0.6-0.6-0.6-0.8-0.6-1.0-1.0-1.31.30.51.2-1.2-0.60.6-0.50.6-0.6-0.5-0.70.80.2
Bone: trabecular number0.91.53.51.31.21.01.01.20.80.81.4-1.4-1.2-1.21.21.2-1.51.3-1.31.3-0.31.4-1.9-0.9
Bone: trabecular spacing0.10.10.60.10.30.10.00.30.30.30.0-0.0-0.3-0.20.2-0.1-0.00.3-0.40.40.80.40.2-0.6
Bone: trabecular thickness0.10.10.40.30.10.40.50.00.40.40.3-0.30.10.1-0.10.6-0.3-0.00.5-0.5-0.6-0.3-0.40.6
Bone: trabecular tissue density0.71.04.7-0.9-0.6-0.7-0.7-0.6-1.0-1.0-1.61.50.50.7-0.7-1.01.1-0.61.0-1.00.8-1.22.2-0.1
Water consumed over 24 hours0.20.30.9-0.3-0.3-0.4-0.4-0.2-0.4-0.4-0.90.90.10.8-0.8-0.30.2-0.10.4-0.4-0.4-0.50.6-0.2
Number of responses in last shaping day0.10.10.7-0.10.1-0.0-0.00.00.10.10.2-0.20.1-0.40.40.10.2-0.1-0.50.50.90.50.00.3