Mtcl1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	mRNA stability	Mtcl1	0.07	0.05	6.4e-03	0.02	0.03	0.03	0.01	3.3e-02	8.5e-03	9.1e-03	1.0e-01
2	LHb	intron excision ratio	chr9_113798955_113809338	0.24	0.12	8.7e-04	0.14	0.13	0.12	0.11	3.7e-04	5.7e-04	8.8e-04	1.8e-03
3	Eye	gene expression	Mtcl1	0.53	0.19	3.9e-03	-0.01	0.02	-0.01	0	5.9e-01	1.6e-01	4.3e-01	2.8e-01
4	BLA	gene expression	Mtcl1	0.07	0.04	1.1e-03	0.05	0.05	0.05	0.05	8.5e-04	9.3e-04	1.7e-03	8.6e-04
5	PL	intron excision ratio	chr9_113798955_113809338	0.03	0.02	2.0e-03	0.02	0.02	0.02	0.02	2.2e-03	1.4e-03	3.7e-03	2.0e-03
6	Brain	isoform ratio	NM_001427344.1	0.05	0.03	3.5e-04	0.02	0.02	0.02	0.02	3.7e-03	4.7e-03	1.0e-02	5.0e-03
7	LHb	intron excision ratio	chr9_113802073_113809338	0.33	0.15	1.9e-03	0.15	0.07	0.11	0.12	2.1e-04	8.8e-03	1.7e-03	7.7e-04
8	Eye	intron excision ratio	chr9_113798955_113809338	0.37	0.16	8.6e-03	0.09	0.06	0.07	0.09	1.7e-02	4.0e-02	3.3e-02	2.0e-02
9	Brain	intron excision ratio	chr9_113798955_113809338	0.03	0.02	8.2e-03	0	0	0	0	1.6e-01	1.5e-01	1.5e-01	2.2e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	0.9	1.5	5.2	2.3	1.0	1.3	0.6	0.2	0.7	1.8	-1.0	-0.6
Area under the delay curve	0.7	0.8	1.3	-1.2	-1.1	-0.4	-1.1	-1.0	-1.0	-0.1	0.4	-0.9
BMI with tail	1.1	3.9	12.2	-3.5	-2.1	-2.8	-2.0	-1.5	-1.6	-1.0	1.1	0.4
BMI without tail	0.6	1.7	6.1	-2.5	-1.3	-1.7	-0.9	-0.5	-0.7	-1.4	1.0	0.8
Body weight	2.3	9.8	28.7	-5.4	-3.3	-4.2	-3.2	-2.7	-2.4	-2.8	-0.3	0.7
Weight adjusted by age	0.2	0.3	0.7	0.2	-0.1	-0.4	-0.8	-0.5	-0.9	0.9	-0.5	-0.4
Bone surface	0.7	1.3	4.6	1.7	0.3	0.5	-0.2	-0.6	-0.0	2.1	-1.4	-1.1
Bone volume	0.8	1.4	4.7	2.2	0.8	1.1	0.4	0.0	0.4	1.9	-1.0	-0.7
Breakpoint value in progressive ratio session	0.1	0.1	0.4	-0.1	0.3	-0.4	-0.1	0.2	-0.6	-0.4	-0.2	0.4
Number of licking bursts	0.2	0.3	1.6	-0.4	0.1	-1.3	-0.6	-0.5	-0.1	0.2	-0.5	0.4
Context. condit. distance diff. score	0.4	0.5	1.1	0.2	0.6	0.5	0.7	1.0	0.2	-0.9	0.7	0.8
Locomotion velocity, session 1	0.6	0.6	3.8	0.2	0.3	-0.9	-0.5	-0.6	0.1	-0.2	-1.9	0.5
Locomotion distance, session 1	2.2	2.8	5.3	-1.9	-1.8	-2.1	-2.3	-2.2	-1.5	0.8	-0.6	-1.1
Locomotion velocity, session 2	0.4	0.4	1.0	-0.2	-0.7	0.1	-0.5	-1.0	-0.6	0.3	-1.0	-0.9
Locomotion distance, session 2	1.0	1.4	1.9	-1.1	-1.4	-0.8	-1.4	-1.4	-1.3	1.1	0.3	-1.3
Locomotion velocity, session 3	0.9	1.0	4.7	-0.4	0.4	-2.2	-1.1	-0.7	0.2	0.2	-1.2	0.9
Locomotion distance, session 3	0.6	0.6	2.0	-0.8	0.4	-1.4	-0.2	0.2	0.1	-0.9	0.2	1.3
Stereotopy head waving bouts, day 3	0.8	0.9	2.5	1.6	1.2	0.9	1.0	0.9	1.1	0.6	-0.1	0.3
Stereotopy head waving duration, day 3	1.7	2.1	6.2	2.5	1.9	0.8	1.0	0.8	1.7	0.6	-1.8	0.7
Locomotion velocity, session 7	0.4	0.5	1.3	-0.1	0.5	0.2	0.6	1.0	0.0	-0.8	1.1	0.8
Locomotion distance, session 7	0.9	1.1	3.7	-0.7	0.1	0.7	0.8	1.2	-0.5	-1.5	1.9	0.7
Stereotopy head waving bouts, day 7	0.1	0.1	0.3	0.2	0.3	-0.2	0.2	0.3	0.6	0.4	0.5	0.2
Stereotopy head waving duration, day 7	0.3	0.4	0.9	0.3	0.5	-0.9	-0.2	-0.2	0.9	0.3	-1.0	0.6
Locomotion velocity, session 8	0.3	0.4	1.5	0.3	-0.1	0.5	0.1	0.2	-0.1	1.0	1.2	-0.6
Locomotion distance, session 8	0.1	0.1	0.3	-0.5	0.0	-0.5	-0.4	0.1	-0.3	-0.2	0.5	0.4
Degree of sensitization distance	1.1	1.1	4.8	0.3	-0.3	2.2	1.1	1.0	-0.4	-0.6	1.4	-0.7
Degree of sensitization stereotypy	0.1	0.1	0.7	-0.5	-0.1	-0.9	-0.4	-0.1	0.1	0.0	0.2	0.2
Conditioned locomotion	1.2	1.3	4.6	-0.3	0.5	0.7	1.2	1.6	0.4	-1.2	2.1	1.0
Cocaine response after cond. corrected	1.3	1.6	4.4	-2.1	-1.6	-1.0	-1.3	-1.1	-1.4	-0.5	0.8	-0.7
Cocaine response after cond. not corrected	1.9	2.2	7.2	-2.7	-1.9	-1.1	-1.4	-1.0	-1.4	-1.1	1.3	-0.5
Cocaine response before conditioning	0.6	0.7	3.1	-0.7	0.0	0.1	0.4	1.0	0.4	-0.9	1.7	0.7
Saline control response	0.9	1.2	2.6	1.6	1.4	1.0	1.3	1.2	1.2	0.1	-0.1	0.8
Bone: connectivity density	1.1	1.7	6.0	2.2	0.6	1.0	0.2	-0.3	0.3	2.4	-1.1	-1.2
Bone: cortical apparent density	0.4	0.6	2.0	-1.4	-0.8	-0.5	-0.5	-0.1	-0.3	-1.1	0.9	0.1
Bone: cortical area	0.5	0.8	1.6	-1.2	-0.7	-1.0	-0.8	-0.7	-0.8	-1.3	-0.8	0.4
Bone: cortical porosity	0.4	0.4	0.9	0.8	0.6	1.0	0.8	0.8	0.4	-0.0	0.4	0.2
Bone: cortical porosity	0.1	0.1	0.5	0.2	0.2	0.5	0.4	0.5	-0.2	0.1	0.7	0.0
Bone: cortical thickness	0.6	1.0	5.1	-1.2	-0.0	-0.9	-0.2	0.1	-0.3	-2.3	-0.4	1.3
Bone: cortical thickness	1.0	1.2	5.3	-1.3	0.1	-1.0	-0.0	0.4	0.2	-2.3	0.1	1.6
Bone: cortical tissue density	0.4	0.6	2.1	-1.5	-0.9	-0.5	-0.5	-0.1	-0.3	-1.0	0.9	0.0
Condit. Reinf. active minus inactive responses	1.7	1.9	5.3	-2.3	-1.1	-1.8	-1.3	-1.0	-1.6	-1.5	-0.2	0.3
Condit. Reinf. active-inactive response ratio	1.8	1.9	4.7	-2.2	-1.5	-1.1	-1.4	-1.2	-2.0	-1.2	-0.1	-0.4
Condit. Reinf. active responses	1.3	1.6	5.1	-2.3	-1.3	-1.4	-1.1	-0.9	-1.4	-1.1	0.7	-0.1
Condit. Reinf. inactive responses	0.3	0.3	1.4	-0.2	-0.5	0.2	0.0	-0.1	-0.1	0.8	1.2	-0.8
Incentive salience index mean	1.6	2.0	5.4	-2.3	-1.5	-1.7	-1.4	-1.3	-1.7	-0.9	-0.1	-0.2
Condit. Reinf. lever presses	0.7	1.0	1.8	-1.0	-1.3	-0.7	-0.9	-1.3	-1.0	0.8	0.0	-1.1
Condit. Reinf. active minus inactive responses	0.8	1.0	2.3	-0.1	0.4	0.8	1.3	1.4	0.6	-1.5	1.1	1.0
Condit. Reinf. active-inactive response ratio	1.1	1.3	4.1	-2.0	-1.6	-0.9	-1.1	-0.9	-0.8	-0.8	0.6	-0.5
Condit. Reinf. active responses	4.0	5.5	10.3	1.8	2.3	2.2	3.2	3.2	2.2	-2.2	0.9	2.3
Condit. Reinf. inactive responses	8.3	10.8	18.5	3.7	4.0	3.1	4.3	4.1	3.2	-1.8	0.1	2.9
Condit. Reinf. lever presses	1.7	2.3	4.2	1.1	1.8	0.7	1.7	1.8	1.4	-1.8	-0.4	2.1
Condit. Reinf. lever reinforcers received	4.6	6.5	11.9	2.0	2.6	2.4	3.4	3.4	2.4	-2.4	0.8	2.5
Conditioned reinforcement - actives	0.4	0.8	2.0	0.3	1.0	-0.2	0.7	0.8	0.7	-1.4	-0.5	1.4
Conditioned reinforcement - inactives	1.5	2.3	8.0	-2.0	-0.6	-1.5	-0.9	-0.6	-0.7	-2.8	-1.7	1.1
Conditioned locomotion	0.6	0.8	1.7	1.3	1.0	0.7	0.8	0.7	1.2	-0.2	-1.1	0.3
Patch foraging indifference point 0 sec	0.1	0.3	1.0	0.7	0.3	1.0	0.3	0.3	-0.7	0.0	-0.1	-0.3
Patch foraging indifference point AUC	0.9	1.2	2.8	-0.8	-1.3	-1.0	-1.3	-1.7	-0.8	0.5	-1.3	-0.8
Delay disc. indifference point, 0s delay	0.9	1.0	2.9	-0.1	-0.7	-1.1	-0.8	-1.5	-0.4	0.8	-1.7	-0.9
Delay disc. indifference point, 16s delay	0.4	0.4	0.8	-0.9	-0.5	-0.5	-0.8	-0.4	-0.8	-0.2	0.8	-0.2
Delay disc. indifference point, 2s delay	1.4	1.6	3.1	-1.1	-1.5	-0.9	-1.4	-1.8	-1.3	0.5	-0.8	-1.4
Delay disc. indifference point, 24s delay	1.2	1.3	3.5	1.9	1.4	1.1	0.8	0.8	1.0	-0.0	-1.6	0.3
Delay disc. indifference point, 4s delay	2.3	2.5	4.4	-1.9	-2.1	-0.9	-1.9	-2.0	-1.8	0.1	0.0	-1.6
Delay disc. indifference point, 8s delay	0.2	0.2	1.0	-0.6	-0.4	0.1	-0.2	-0.1	0.0	-0.2	1.0	-0.3
Indifference point function ln k	1.5	2.6	4.4	1.9	2.1	1.2	1.9	2.1	1.7	0.1	1.0	1.3
Indifference point function log k	1.5	2.6	4.4	1.9	2.1	1.2	1.9	2.1	1.7	0.1	1.0	1.3
Patch foraging total patch changes 0 sec	0.1	0.2	0.9	0.7	0.3	0.9	0.3	0.3	-0.6	0.1	-0.1	-0.2
Patch foraging total patch changes 12 sec	0.6	0.8	1.6	-0.4	-0.9	-0.3	-1.2	-1.1	-1.3	0.7	-0.4	-1.0
Patch foraging total patch changes 18 sec	1.3	1.9	4.0	-0.6	-1.5	-0.2	-1.5	-1.9	-2.0	0.5	-1.7	-1.5
Patch foraging total patch changes 24 sec	1.1	1.8	4.6	-1.2	-1.8	0.3	-1.0	-1.1	-2.1	0.7	1.1	-1.8
Patch foraging total patch changes 6 sec	0.5	0.8	1.9	-0.1	-0.9	-0.1	-0.9	-1.2	-1.4	0.9	-0.8	-1.1
Patch foraging time to switch 0 sec	0.1	0.1	0.4	-0.2	-0.4	0.6	-0.0	-0.1	-0.2	-0.6	-0.1	-0.5
Patch foraging water rate 0 sec	0.4	0.9	1.8	-1.2	-0.9	-0.9	-0.8	-0.6	-1.2	0.6	1.3	-0.5
Patch foraging water rate 12 sec	0.2	0.3	1.3	-0.3	-0.1	0.7	0.5	0.6	-0.5	-0.5	1.2	0.1
Patch foraging water rate 18 sec	1.2	1.9	3.6	-1.9	-1.6	-1.2	-1.5	-1.2	-1.8	0.5	1.2	-0.9
Patch foraging water rate 24 sec	0.3	0.4	2.1	-0.8	-0.8	0.2	-0.1	-0.1	-0.3	0.3	1.5	-0.5
Patch foraging water rate 6 sec	0.5	0.7	3.0	-0.4	-0.3	1.1	0.9	0.8	-0.5	-0.7	1.7	0.1
Seeking ratio, delayed vs. immediate footshock	1.1	1.3	2.1	0.9	1.2	0.5	1.4	1.1	1.2	-1.3	-1.2	1.3
Distance traveled before self-admin	0.2	0.3	0.6	-0.2	-0.5	0.1	-0.5	-0.3	0.1	0.7	0.8	-0.7
Distance traveled after self-admin	0.1	0.2	0.5	-0.1	-0.1	0.1	-0.5	-0.3	-0.7	-0.2	-0.7	-0.4
Extensor digitorum longus weight	0.4	1.6	3.5	-1.3	-1.9	0.3	-0.9	-1.1	-1.7	0.4	0.9	-1.7
Bone: elastic displacement	0.9	1.0	2.5	-0.3	0.8	-0.1	0.8	1.3	0.6	-1.6	0.7	1.6
Bone: elastic work	0.2	0.2	0.8	-0.3	0.4	-0.5	-0.1	0.3	-0.3	-0.8	-0.0	0.9
Bone: endosteal estimation	0.1	0.3	1.0	0.8	0.0	0.3	-0.0	-0.4	-0.1	1.0	-0.8	-0.5
Bone: endosteal perimeter	0.2	0.5	1.1	0.1	-0.7	0.0	-0.6	-1.0	-0.4	1.0	-0.7	-1.0
Epididymis fat weight	0.9	3.0	5.7	-2.4	-2.3	-1.4	-2.1	-2.1	-1.8	-0.6	-0.7	-1.0
Delta time in closed arm before/after self-admin	1.2	1.1	2.2	-0.7	-1.1	-0.2	-0.9	-0.9	-1.1	1.3	1.5	-1.4
Delta time in open arm before/after self-admin	0.3	0.3	0.7	-0.8	-0.6	-0.8	-0.5	-0.5	0.8	-0.2	-0.2	-0.1
Diff in mean of infusions in LGA sessions	0.4	0.5	3.9	0.7	0.2	0.1	0.3	-0.3	0.0	0.4	-2.0	0.0
Delay discount exponential model param	0.7	0.8	1.4	1.2	1.1	0.3	1.1	0.9	1.0	0.1	-0.5	0.9
Extinction: sum of active levers before priming	1.1	1.2	2.3	-1.2	-1.4	-1.0	-1.3	-1.5	-0.9	0.3	-0.6	-1.0
Active lever presses in extinction session 6	0.9	0.9	3.6	-1.1	-0.7	-0.7	-0.8	-0.8	-1.9	-0.7	-0.3	-0.3
Bone: final force	0.6	0.9	3.0	-0.6	-0.2	-1.7	-1.2	-1.0	-0.4	-0.1	-1.4	0.4
Bone: final moment	0.5	0.8	2.5	-0.5	-0.1	-1.6	-1.0	-0.9	-0.4	-0.1	-1.4	0.5
Food consumed during 24 hour testing period	0.7	0.9	3.6	-0.7	-0.1	-1.9	-1.3	-1.0	0.1	0.2	-1.1	0.4
Glucose	0.3	0.4	1.0	0.5	1.0	0.1	0.5	0.7	1.0	-0.7	-0.2	0.8
Heart weight	1.1	1.7	4.2	-2.1	-1.8	-1.2	-1.4	-1.3	-1.4	-0.7	0.0	-0.5
Delay discount hyperbolic model param	0.8	0.9	1.6	1.3	1.2	0.3	1.1	1.0	1.0	0.1	-0.5	1.0
Intermittent access intake day 1-15 change	0.5	1.0	4.3	1.0	0.7	1.4	0.6	0.3	0.7	-0.6	-2.1	-0.0
Intermittent access intake escalation	0.4	0.9	5.0	0.9	0.5	1.2	0.3	0.1	0.4	-0.5	-2.2	-0.3
Intermittent access intake escalation 2	1.4	1.6	4.9	-0.7	-1.3	0.1	-1.4	-1.6	-1.1	-0.0	-2.2	-1.4
Intermitt. access day 1 inactive lever presses	0.1	0.4	1.3	-0.4	-0.2	-0.9	0.1	-0.3	0.5	-0.9	-1.2	0.8
Intermitt. access day 15 inactive lever presses	0.6	1.2	5.7	-0.7	0.2	1.5	0.6	1.0	-0.7	-2.4	-0.1	0.9
Intermitt. access escalation Index	1.0	1.5	4.3	-0.7	-0.8	-0.8	-1.0	-0.7	-0.9	1.7	2.1	-1.3
Intermittent access day 1 total infusions	0.5	0.9	1.9	-0.2	1.0	-0.3	0.6	1.1	0.9	-1.3	0.9	1.4
Intermittent access day 15 total infusions	0.4	0.5	1.8	0.1	0.8	0.4	0.5	0.7	0.8	-1.4	-0.4	0.8
Intermittent access terminal intake (last 3 days)	0.2	0.3	0.8	0.1	0.6	0.2	0.5	0.5	0.9	-0.9	-0.3	0.7
Intermittent access total infusions	0.4	0.4	1.1	-0.3	0.8	-0.4	0.2	0.7	0.6	-1.0	0.7	0.8
Intermittent access day 1 locomotion	0.7	0.9	2.9	-0.4	0.7	-0.9	0.4	0.7	1.1	-1.7	-0.0	1.4
Intermittent access day 15 total locomotion	1.3	2.3	5.2	0.5	1.5	0.1	1.3	1.3	2.2	-2.3	-1.3	1.8
Intermittent access total locomotion	1.0	1.2	3.2	0.3	1.2	-0.2	0.8	0.9	1.4	-1.8	-0.9	1.3
Intermittent access standard deviation	0.4	0.8	2.6	-1.2	-0.2	-1.1	-0.4	-0.4	0.1	-1.6	-0.9	0.8
Left kidney weight	1.1	5.2	16.6	-4.1	-2.2	-3.0	-2.1	-1.6	-1.9	-2.4	0.5	0.5
Right kidney weight	2.2	9.9	28.8	-5.4	-3.1	-4.6	-3.2	-2.6	-2.2	-2.6	-0.1	0.6
Cocaine induced anxiety	0.6	0.9	2.1	-0.9	-1.4	-0.4	-1.0	-1.2	-1.0	0.7	0.2	-1.1
Post-drug Anxiety	1.1	1.2	2.1	-1.1	-1.4	-0.3	-1.0	-1.0	-1.3	0.8	1.1	-1.2
Baseline Anxiety	0.2	0.2	0.7	0.2	0.8	-0.2	0.2	0.6	0.3	-0.1	0.8	0.5
Tail length	0.9	3.4	8.4	-2.9	-1.9	-2.2	-2.1	-1.8	-1.8	-1.4	-0.6	-0.2
Length with tail	1.3	5.8	10.8	-3.3	-2.0	-3.2	-2.5	-2.5	-1.7	-2.3	-2.4	0.4
Length without tail	2.1	6.6	12.1	-3.5	-2.4	-3.4	-3.0	-2.9	-2.3	-1.7	-2.2	-0.1
Times rat made contact with spout	0.2	0.2	0.6	0.1	0.6	-0.7	-0.0	0.2	-0.7	-0.1	-0.3	0.8
Lifetime Intake	0.4	0.5	1.3	-0.0	1.0	-0.4	0.3	0.8	0.8	-1.1	0.2	1.0
Liver weight, left	0.3	0.5	1.7	-1.1	-0.7	-0.4	-0.2	-0.4	-0.4	-1.3	-0.5	0.3
Liver weight, right	0.6	1.1	6.8	-0.6	0.2	0.5	0.7	0.8	0.2	-2.6	-0.2	1.0
Locomotor activity	0.6	0.9	2.1	0.4	0.9	0.5	1.2	1.1	0.8	-1.3	-0.0	1.4
Locomotor testing distance	0.8	1.4	2.5	1.0	1.3	0.7	1.5	1.3	1.2	-1.2	-0.6	1.6
Locomotor testing rearing	2.0	4.1	6.1	2.3	2.4	1.4	2.5	2.2	2.2	-1.2	-0.8	2.3
Locomotion in novel chamber	1.0	1.3	2.3	-1.5	-1.0	-1.5	-1.0	-1.2	-0.4	-1.0	-1.5	-0.3
Locomotion in novel chamber post-restriction	0.3	0.5	2.7	-0.9	-0.4	-1.6	-0.4	-0.7	-0.4	-0.2	-0.4	0.1
Fecal boli incidents, locomotor time 1	1.1	1.6	3.4	-1.3	-1.4	-1.1	-1.8	-1.7	-1.0	0.6	-0.6	-1.3
Change in fecal boli incidents, locomotor task	2.4	2.4	4.4	1.4	1.1	2.0	2.1	1.7	1.9	-1.2	-0.4	1.3
Time >=10cm from walls, locomotor time 1	0.3	0.4	0.9	-0.3	-0.7	0.0	-0.8	-0.7	-0.6	0.6	-0.1	-0.9
Bouts of movement, locomotor time 1	0.4	0.4	2.0	-0.1	0.6	0.1	0.2	0.6	0.2	-1.4	-0.4	0.9
Total resting periods, locomotor time 1	0.4	0.4	1.9	-0.2	0.6	0.0	0.3	0.6	0.1	-1.4	-0.2	0.9
Rest time, locomotor task time 1	0.1	0.1	0.3	-0.4	-0.0	0.4	0.5	0.4	0.1	-0.5	0.3	0.4
Distance moved, locomotor task time 1	0.1	0.2	0.7	0.6	0.2	0.0	-0.4	-0.1	0.1	0.9	-0.0	-0.6
Vertical activity count, locomotor time 1	0.3	0.8	4.6	0.6	0.4	-1.1	-0.5	-0.6	0.4	0.2	-2.1	0.0
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.4	0.2	-0.2	0.3	-0.6	-0.3	-0.2	0.3	-0.5	-0.6
Bouts of movement, locomotor time 2	0.3	0.4	1.0	1.0	0.9	-0.0	0.3	0.6	0.4	1.0	0.6	0.2
Total resting periods, locomotor time 2	0.2	0.3	0.6	0.5	0.7	-0.5	0.2	0.5	0.3	0.6	0.6	0.5
Rest time, locomotor task time 2	0.7	0.9	2.6	-1.6	-1.3	-0.4	-0.6	-0.8	-0.9	-0.1	1.3	-0.7
Distance moved, locomotor task time 2	1.4	1.7	4.0	1.8	2.0	0.4	0.9	1.4	1.6	-0.3	-0.9	1.3
Vertical activity count, locomotor time 2	0.7	1.0	4.6	1.4	1.1	-0.2	-0.2	0.2	0.7	-0.0	-2.1	0.6
Light reinforcement 1	0.2	0.6	1.8	1.0	0.8	-0.7	0.2	0.1	0.8	1.3	-0.4	0.5
Light reinforcement 2	0.6	0.9	4.1	0.2	0.4	-1.4	-0.4	-0.2	0.6	2.0	1.0	-0.0
Bone: marrow area	0.2	0.4	1.2	0.7	-0.1	0.2	-0.2	-0.6	-0.2	1.1	-0.9	-0.7
Bone: maximum diameter	0.5	0.9	1.9	-0.9	-1.4	-0.3	-1.1	-1.2	-1.1	0.2	-0.3	-1.1
Bone: maximum force	0.7	1.3	3.2	-1.5	-0.7	-1.8	-1.4	-1.1	-1.0	-0.8	-1.0	0.4
Bone: maximum moment	0.7	1.1	2.8	-1.4	-0.6	-1.7	-1.2	-1.0	-0.9	-0.9	-1.0	0.5
Mean time between licks in bursts	1.0	2.5	5.2	1.1	1.9	0.3	1.5	1.6	1.8	-2.0	-1.0	2.3
Mean num. licks in bursts	0.3	0.4	1.2	0.5	0.4	1.1	0.9	0.9	-0.1	-0.6	0.6	0.2
Cd content in liver	0.5	0.5	1.8	-0.5	0.4	-0.8	0.1	0.5	0.5	-1.2	-0.1	1.3
Co content in liver	0.9	1.0	3.7	-0.4	0.9	-1.4	0.2	0.6	0.9	-1.2	-0.2	1.9
Cu content in liver	1.7	2.0	7.4	-2.2	-0.8	-2.7	-1.3	-0.8	-1.0	-0.6	0.5	1.2
Fe content in liver	0.9	1.1	2.5	1.3	1.1	1.4	1.6	1.3	0.4	-0.6	0.0	0.6
K content in liver	0.1	0.1	0.4	-0.3	-0.0	-0.6	-0.2	-0.2	0.1	-0.1	-0.2	0.3
Mg content in liver	0.4	0.4	1.3	-0.1	0.6	-0.5	0.4	0.4	-0.1	-1.1	-0.6	1.1
Mn content in liver	1.5	1.7	3.7	1.7	1.9	0.6	1.5	1.5	1.4	-0.3	-0.5	1.2
Na content in liver	0.8	0.9	2.5	0.7	1.3	-0.8	0.7	0.7	1.2	-0.1	-0.5	1.6
Rb content in liver	1.1	1.3	4.8	-0.7	-0.9	-0.2	-0.5	-0.3	-2.2	1.3	1.7	-1.0
Se content in liver	1.0	1.2	2.5	0.8	0.9	1.1	1.4	1.6	1.3	-0.1	1.4	0.6
Sr content in liver	0.7	0.6	2.6	1.1	0.6	0.5	0.6	0.4	1.6	0.7	-0.1	0.2
Zn content in liver	0.4	0.5	1.7	-0.9	-0.6	-0.8	-0.6	-0.4	-1.3	-0.0	0.4	-0.1
Bone: minimum diameter	0.2	0.3	0.8	-0.3	-0.5	0.1	-0.3	-0.5	-0.9	-0.5	-0.9	-0.3
Time in familiar zone, hab. session 1	0.5	0.5	1.6	0.8	0.5	-0.6	-0.1	-0.1	1.2	1.2	-0.5	0.1
Time in novel zone, hab. session 1	0.3	0.3	1.2	-0.7	-0.6	0.1	-0.3	-0.3	-1.1	-0.5	0.2	-0.2
Total zone transitions, hab. session 1	0.4	0.6	2.5	-0.1	-0.4	-0.1	-0.1	-0.1	-0.0	1.5	1.6	-0.7
Total locomotion distance, hab. session 1	1.1	1.6	5.8	-2.0	-1.2	-1.2	-0.8	-0.3	-1.0	0.3	2.4	-0.3
Locomotion velocity, hab. session 1	0.8	1.1	5.1	-1.4	-0.9	-0.8	-0.5	-0.1	-0.8	0.6	2.3	-0.3
Time in familiar zone, hab. session 2	0.5	0.5	1.7	0.9	0.3	1.3	0.7	0.3	0.5	-0.6	-1.0	-0.1
Time in novel zone, hab. session 2	0.6	0.6	2.2	-0.6	-0.2	-1.5	-1.1	-0.7	-0.5	0.9	0.0	0.0
Total zone transitions, hab. session 2	0.1	0.2	0.6	0.2	0.3	-0.3	0.3	0.3	0.3	0.7	0.8	0.3
Total locomotion distance, hab. session 2	0.4	0.6	2.7	-1.2	-0.5	-0.7	-0.2	0.1	-0.3	-0.0	1.7	0.2
Locomotion velocity, hab. session 2	0.5	0.6	3.0	-1.2	-0.5	-0.7	-0.0	0.2	-0.2	-0.2	1.7	0.3
Novel to familiar place preference ratio	0.2	0.2	1.0	-0.5	-0.3	0.1	-0.1	-0.1	-1.0	-0.6	0.0	0.0
Novelty place preference	0.1	0.1	0.9	-0.3	-0.2	0.1	-0.1	-0.0	-0.9	-0.4	0.0	0.0
Time in novel zone, NPP test	0.1	0.1	0.7	-0.3	-0.2	0.3	0.0	0.1	-0.8	-0.6	0.2	0.0
Total zone transitions, NPP test	0.1	0.2	1.2	-0.4	-0.2	-0.3	0.1	0.1	0.1	0.4	1.1	-0.0
Total locomotion distance, NPP test	0.3	0.4	0.9	-0.9	-0.1	-0.7	0.1	0.2	0.1	-0.9	0.8	0.7
Locomotion velocity, NPP test	0.3	0.4	1.1	-1.0	-0.2	-0.6	0.0	0.2	-0.1	-0.7	1.1	0.5
Intraocular pressure	0.9	1.2	5.3	1.5	0.1	2.3	1.3	0.4	0.6	0.4	-0.5	-0.9
Delta distance traveled before/after self-admin	0.9	1.0	2.1	0.6	1.4	0.1	0.7	1.0	0.1	-1.4	-1.2	1.3
Delta ambulatory time before/after self-admin	0.9	1.1	2.3	0.6	1.5	0.1	0.8	1.1	0.2	-1.5	-1.0	1.4
Parametrial fat weight	0.3	0.8	3.6	-0.6	0.3	0.1	0.7	0.8	0.4	-1.9	0.5	1.3
Pavlov. Cond. lever latency	1.3	1.6	3.1	1.6	1.8	1.0	1.3	1.7	1.4	-0.2	0.3	1.1
Pavlov. Cond. magazine entry latency	0.3	0.3	1.1	-0.5	-0.1	-0.9	-0.3	-0.5	-0.0	-0.6	-1.0	0.5
Pavlov. Cond. change in total contacts	2.6	2.8	5.0	-2.2	-1.9	-2.2	-1.9	-2.1	-1.7	0.6	-0.3	-0.9
Pavlov. Cond. index score	0.8	1.0	2.1	-1.4	-1.1	-1.3	-1.0	-1.2	-0.9	-0.3	-0.5	-0.2
Pavlov. Cond. latency score	1.0	1.3	2.7	-1.6	-1.3	-1.4	-1.2	-1.4	-1.0	-0.4	-0.6	-0.3
Pavlov. Cond. lever contacts	1.2	1.5	2.9	-1.7	-1.7	-1.1	-1.1	-1.5	-1.3	0.1	-0.1	-0.9
Pavlov. Cond. magazine entry number	0.2	0.2	0.7	0.5	0.2	0.9	0.3	0.5	0.2	0.3	0.7	-0.3
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.6	-0.7	-0.1	-0.6	-0.2	0.0	-0.5	-0.5	0.6	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	1.9	-1.4	-1.2	-1.2	-1.1	-1.3	-1.0	-0.0	-0.4	-0.5
Pavlov. Cond. response bias	0.3	0.4	0.8	-0.7	-0.7	-0.8	-0.7	-0.9	-0.6	0.2	-0.4	-0.3
Pavlov. Cond. lever latency	1.9	2.6	7.8	-0.8	-2.1	0.9	-1.1	-1.4	-1.9	1.4	0.9	-2.8
Pavlov. Cond. magazine entry latency	3.3	3.9	7.6	-2.0	-1.8	-2.6	-2.8	-2.6	-2.1	0.6	-1.4	-0.9
Pavlov. Cond. change in total contacts	1.4	2.3	6.1	1.0	2.1	-0.4	1.3	1.6	1.7	-1.2	-0.4	2.5
Pavlov. Cond. index score	0.8	1.0	3.0	-0.3	0.8	-1.6	-0.3	0.0	0.4	-1.1	-1.3	1.7
Pavlov. Cond. latency score	0.9	1.2	4.3	-0.6	0.5	-2.1	-0.8	-0.5	0.2	-0.7	-1.5	1.5
Pavlov. Cond. lever contacts	1.8	2.5	7.9	0.7	2.0	-1.0	1.0	1.4	1.7	-1.6	-1.0	2.8
Pavlov. Cond. magazine entry number	1.4	1.7	3.2	1.2	1.0	1.8	1.8	1.7	1.5	-0.2	1.3	0.3
Pavlov. Cond. intertrial magazine entries	1.9	2.8	5.5	1.5	1.5	2.0	2.4	2.2	1.7	-1.2	0.9	1.1
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.1	3.0	-0.4	0.7	-1.7	-0.5	-0.2	0.3	-1.1	-1.5	1.7
Pavlov. Cond. response bias	1.2	1.7	5.0	0.7	1.7	-0.5	0.9	1.2	1.2	-1.4	-0.9	2.2
Time in closed arm before self-admin	0.1	0.1	0.3	0.5	0.1	0.5	0.4	0.1	-0.0	0.5	-0.1	-0.3
Time in closed arm after self-admin	0.4	0.4	1.1	-0.2	-0.5	-0.0	-0.3	-0.4	-0.4	1.0	1.1	-0.8
Time in open arm before self-admin	0.6	0.7	1.6	1.3	0.7	1.2	1.2	0.7	0.1	0.1	-0.7	0.2
Time in open arm after self-admin	0.5	0.6	1.6	-1.3	-0.8	-0.8	-0.5	-0.6	-0.2	-1.0	-0.6	0.1
Bone: periosteal estimation	0.1	0.3	0.9	-0.2	-0.4	-0.5	-0.6	-0.7	-0.6	0.1	-1.0	-0.2
Bone: periosteal perimeter	0.1	0.1	0.6	0.0	-0.2	-0.3	-0.4	-0.5	-0.2	0.1	-0.8	-0.1
Bone: post-yield work	0.1	0.1	0.2	0.2	0.3	-0.4	-0.1	-0.0	0.5	0.2	-0.3	0.3
Progressive ratio test 1 active lever presses	1.4	1.7	4.4	-0.4	1.1	-0.8	1.0	1.2	1.4	-1.9	0.7	2.1
Progressive ratio test 1 breakpoint	1.4	1.7	4.3	-0.4	1.1	-0.8	1.0	1.3	1.4	-1.8	0.8	2.1
Progressive ratio test 1 inactive lever presses	1.9	2.8	4.8	1.0	1.7	0.8	2.2	1.9	2.0	-1.7	-0.2	2.2
Progressive ratio test 2 active lever presses	0.4	0.4	1.2	0.0	0.7	-0.3	0.5	0.5	0.7	-1.1	-0.4	1.1
Progressive ratio test 2 breakpoint	0.3	0.4	1.0	-0.1	0.6	-0.3	0.4	0.5	0.6	-1.0	-0.2	1.0
Progressive ratio test 2 inactive lever presses	0.7	1.2	6.6	-1.0	0.3	0.5	0.5	0.9	-0.0	-2.6	0.0	1.3
Incentive Sensitization - Responses	0.0	0.0	0.1	0.4	0.1	0.2	0.1	-0.0	0.1	0.3	-0.4	-0.0
Incentive Sensitization - Breakpoint	0.0	0.0	0.1	0.4	0.0	0.3	0.2	-0.0	0.0	0.4	-0.2	-0.1
Sum of active levers in priming session hrs 5-6	0.5	0.5	1.4	-0.4	-0.0	-1.0	-0.7	-0.6	-1.2	0.0	-0.9	-0.1
Progressive ratio	1.0	1.5	4.9	2.0	0.6	1.0	0.7	-0.0	0.9	1.3	-2.2	-0.7
Food seeking constrained by brief footshock	0.6	0.7	4.9	0.9	0.4	0.0	0.2	-0.2	0.8	0.0	-2.2	0.2
Seeking ratio, punishment vs. effort	0.3	0.5	1.3	-1.2	-0.3	-0.9	-0.7	-0.2	-0.3	-0.8	0.7	0.6
Retroperitoneal fat weight	1.6	6.9	16.5	-4.1	-2.8	-3.3	-2.8	-2.7	-2.2	-2.1	-1.4	0.0
Reaction time number correct	0.8	1.5	5.3	1.9	1.2	0.3	0.8	0.2	1.1	0.5	-2.3	0.5
Reaction time mean minus median	0.3	0.7	1.4	-1.0	-0.9	-1.0	-1.2	-1.1	-0.6	0.5	-0.1	-0.6
Reaction time mean minus median AUC	0.3	0.9	1.7	-0.7	-0.8	-1.1	-1.3	-1.3	-0.6	0.8	-0.7	-0.8
Reaction time num false alarms	4.3	6.0	9.6	-2.5	-2.8	-2.7	-3.0	-3.1	-2.4	2.0	0.1	-2.0
Reaction time num false alarms AUC	4.0	6.2	9.6	-2.5	-2.8	-2.6	-3.0	-3.1	-2.6	2.1	0.3	-2.2
Reaction time trials correct on left	0.8	1.5	5.3	1.9	1.2	0.3	0.8	0.2	1.1	0.5	-2.3	0.5
Reaction time trials on left	0.7	1.4	5.3	1.9	1.2	0.3	0.7	0.1	1.0	0.5	-2.3	0.5
Reaction time mean	0.4	0.7	1.2	-1.0	-0.9	-0.6	-1.1	-0.9	-1.1	0.2	-0.0	-0.7
Reaction time mean AUC	0.5	0.7	1.3	-0.7	-0.9	-0.6	-1.2	-1.1	-1.0	0.8	-0.2	-1.0
Median of all reaction times	0.4	0.5	1.2	-0.8	-0.8	-0.5	-1.0	-0.8	-1.1	0.2	-0.1	-0.7
Reaction time omissions	0.1	0.1	0.3	-0.5	-0.1	-0.5	-0.4	-0.1	-0.3	-0.3	0.3	0.2
Reaction time false alarm rate	5.1	7.1	12.3	-3.5	-3.2	-2.7	-3.2	-2.9	-2.9	1.1	1.3	-2.0
Reaction time premature initiation rate	0.6	0.8	1.7	0.9	1.1	1.0	1.1	1.3	0.7	-0.3	0.7	0.6
Reaction time premature initiations	0.8	1.4	3.6	1.9	1.4	1.3	1.4	1.1	1.1	0.2	-0.7	0.5
Std. dev. reaction times	0.2	0.4	1.1	-1.1	-0.6	-0.8	-0.9	-0.6	-0.6	-0.0	0.3	-0.3
Reaction time trials completed	0.7	1.4	5.3	1.9	1.2	0.3	0.7	0.1	1.0	0.5	-2.3	0.5
Reaction time trials AUC	0.6	1.2	4.6	1.7	1.1	0.3	0.7	0.2	0.9	0.3	-2.2	0.4
Run reversals in cocaine runway, females	0.7	0.7	2.3	0.6	0.3	1.5	1.2	0.9	0.7	-0.6	0.1	0.5
Run reversals in cocaine runway, males	0.7	0.7	1.5	0.0	-0.3	0.7	-0.5	-0.1	-1.1	1.0	1.2	-1.2
Latency to leave start box in cocaine runway	0.1	0.2	0.5	0.1	0.3	0.1	0.4	0.4	0.7	0.0	0.7	0.1
Latency to leave start box in cocaine runway, F	0.6	0.7	2.3	0.3	-0.4	-0.4	-0.6	-0.9	0.2	1.5	-0.7	-1.3
Latency to leave start box in cocaine runway, M	2.7	2.5	6.7	-0.2	1.1	0.8	1.6	2.1	1.0	-1.8	2.6	1.8
Std. dev. time between licks in bursts	0.2	0.3	0.9	-0.2	0.3	-0.7	0.1	0.2	-0.3	-0.9	-0.7	0.9
Total sessions with >9 infusions	0.6	0.8	1.9	0.2	1.1	-0.4	0.6	0.9	1.1	-1.2	-0.0	1.4
Short access day 1 total inactive lever presses	1.3	1.7	5.9	-0.3	0.6	-0.1	0.9	0.7	1.4	-2.4	-1.4	1.9
Short access day 10 total inactive lever presses	0.1	0.2	1.1	-0.3	0.1	0.4	0.5	0.4	-0.1	-1.1	-0.4	0.6
Short access day 1 total infusions	0.3	0.4	1.0	-0.3	0.5	-0.8	-0.2	0.1	0.4	-1.0	-0.6	0.7
Short access day 10 total infusions	0.6	0.7	1.6	1.0	1.3	0.5	0.9	1.1	1.1	-0.1	0.4	0.6
Short access total infusions	0.6	0.8	1.5	0.5	1.2	0.3	0.8	1.1	1.1	-1.0	0.0	1.1
Short access day 1 locomotion	0.2	0.3	0.6	0.2	0.7	-0.5	0.0	0.2	0.3	-0.7	-0.8	0.7
Short access day 10 total locomotion	1.6	2.9	8.1	0.8	1.7	-0.2	1.7	1.5	2.8	-1.8	-0.9	2.3
Short access total locomotion	1.0	1.2	2.8	0.8	1.5	-0.6	0.8	0.8	1.7	-0.8	-0.9	1.3
One hour access (0.3 mA shock)	1.5	1.7	5.6	0.5	1.3	0.1	0.6	0.6	0.7	-2.1	-2.4	1.4
Compulsive drug intake	0.2	0.3	0.8	-0.1	-0.9	0.5	-0.1	-0.6	-0.6	0.3	-0.4	-0.6
One hour access (shock baseline)	0.7	1.1	2.7	0.5	1.3	0.0	0.5	0.8	0.8	-1.6	-1.4	1.2
Social response proportion	1.7	2.0	4.2	-0.8	-1.3	-1.2	-1.9	-2.1	-1.0	0.7	-1.7	-1.4
Social responses	0.9	1.2	6.5	-0.3	-0.5	-1.0	-0.8	-1.2	0.2	-0.7	-2.6	0.2
Social time	1.1	1.4	3.3	0.8	1.1	-0.5	1.0	0.5	1.6	-1.1	-1.8	1.5
Soleus weight	0.7	2.0	4.1	-1.4	-1.2	-2.0	-1.9	-1.4	-1.1	1.7	0.9	-0.7
Bone: stiffness	0.3	0.5	1.2	-0.8	-0.5	-1.1	-0.9	-0.8	-0.5	-0.2	-0.7	0.0
Tibialis anterior weight	1.3	4.5	8.1	-2.6	-2.9	-1.3	-2.4	-2.2	-2.4	1.0	1.2	-2.2
Time to tail flick, vehicle, before self-admin	1.1	1.1	7.6	1.0	0.2	0.8	0.4	-0.3	0.8	-0.1	-2.8	0.1
Time to tail flick, vehicle, after self-admin	0.1	0.2	0.3	0.5	-0.0	0.6	0.6	0.1	0.2	0.3	-0.5	0.0
Time to tail flick, test, before self-admin	0.4	0.4	1.0	0.9	0.8	0.3	0.3	0.4	1.0	0.0	-0.9	0.2
Time to tail flick, test, after self-admin	1.6	1.6	3.7	1.9	1.9	0.9	1.3	1.4	0.8	0.1	-0.9	1.2
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	3.3	-0.9	-0.6	-0.7	-0.4	-0.3	-0.8	0.6	1.8	-0.4
Delta time to tail flick, test, before/after SA	0.2	0.2	1.3	0.4	0.1	0.2	0.2	-0.0	-1.2	0.2	-0.5	0.1
Tibia length	0.6	1.6	4.8	-2.2	-1.2	-0.6	-0.6	-0.3	-1.5	-1.9	1.0	0.2
Ambulatory time before self-admin	0.1	0.2	0.7	0.1	-0.4	0.3	-0.3	-0.2	0.1	0.9	0.6	-0.7
Ambulatory time after self-admin	0.2	0.2	0.7	-0.6	-0.0	-0.3	-0.3	-0.0	-0.8	-0.8	0.1	0.2
Bone: tissue strength	0.2	0.2	1.0	0.5	0.2	-0.1	-0.1	-0.1	0.2	1.0	0.0	-0.2
Total heroin consumption	0.4	0.4	1.8	0.7	0.4	0.4	0.7	0.2	0.8	-0.1	-1.3	0.2
Bone: trabecular number	1.0	1.6	5.7	2.4	1.3	1.1	0.8	0.6	1.1	1.8	-0.7	-0.3
Bone: trabecular spacing	0.8	1.1	2.6	-1.6	-1.5	-0.5	-0.9	-0.9	-1.5	-0.3	0.6	-0.8
Bone: trabecular thickness	1.4	1.7	4.3	2.1	1.7	0.6	1.1	1.0	1.9	0.5	-1.0	0.9
Bone: trabecular tissue density	0.7	1.0	3.4	-1.6	-0.7	-1.8	-1.2	-0.7	-0.3	-0.1	0.5	0.3
Water consumed over 24 hours	0.2	0.2	0.5	0.7	0.6	0.1	0.2	0.1	-0.6	0.4	-0.6	0.2
Number of responses in last shaping day	0.3	0.3	1.3	-0.1	0.4	-0.2	0.0	0.2	0.1	-1.1	-1.1	0.6