Hub : Genes

Mta1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Mta1	0.02	0.01	7.0e-03	0.01	0.02	0.01	0.02	7.6e-03	2.7e-03	9.7e-03	6.0e-03
2	Brain	gene expression	Mta1	0.07	0.05	7.5e-03	0.01	0	0.01	0.01	7.1e-02	1.7e-01	5.9e-02	9.0e-02
3	Liver	alternative TSS	XM_039112879.2	0.03	0.03	1.5e-03	0.01	0.01	0.01	0.01	1.4e-02	1.7e-02	2.2e-02	2.2e-02
4	Liver	alternative TSS	XM_039112879.2	0.04	0.04	7.2e-04	0.03	0.02	0.02	0.02	7.4e-04	5.5e-03	4.1e-03	4.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.3	0.6	1.3	0.1	1.2	0.7	0.7
Area under the delay curve	0.5	0.6	1.7	-1.3	-0.2	0.6	0.6
BMI with tail	1.2	4.2	10.1	-2.5	-3.2	0.4	0.4
BMI without tail	0.9	2.6	7.0	-1.9	-2.7	-0.0	-0.0
Body weight	1.1	4.9	6.8	2.6	0.8	-2.5	-2.5
Weight adjusted by age	0.1	0.2	0.4	0.7	0.2	-0.4	-0.4
Bone surface	1.4	2.6	3.8	-1.0	1.4	1.9	1.9
Bone volume	1.2	2.2	3.2	-0.8	1.3	1.8	1.8
Breakpoint value in progressive ratio session	0.4	0.4	0.7	0.8	0.0	-0.7	-0.7
Number of licking bursts	0.8	1.3	1.9	-1.4	-0.1	1.3	1.3
Context. condit. distance diff. score	1.5	1.9	4.3	1.8	2.1	-0.2	-0.2
Locomotion velocity, session 1	1.9	2.0	3.1	0.7	-1.1	-1.8	-1.8
Locomotion distance, session 1	2.4	3.0	4.6	-0.0	-2.1	-1.9	-1.9
Locomotion velocity, session 2	0.6	0.7	1.8	-0.4	-1.3	-0.7	-0.7
Locomotion distance, session 2	2.0	2.7	6.2	-0.6	-2.5	-1.5	-1.5
Locomotion velocity, session 3	0.0	0.0	0.1	-0.2	-0.3	-0.2	-0.2
Locomotion distance, session 3	0.7	0.8	1.3	-0.1	-1.2	-1.0	-1.0
Stereotopy head waving bouts, day 3	0.1	0.1	0.2	0.1	0.4	0.3	0.3
Stereotopy head waving duration, day 3	0.4	0.5	1.1	0.1	1.0	0.7	0.7
Locomotion velocity, session 7	0.1	0.1	0.2	0.2	0.4	0.2	0.2
Locomotion distance, session 7	0.4	0.5	0.9	-1.0	-0.9	0.3	0.3
Stereotopy head waving bouts, day 7	1.4	1.6	4.4	1.4	2.1	-0.1	-0.1
Stereotopy head waving duration, day 7	1.2	1.5	4.3	1.2	2.1	0.3	0.3
Locomotion velocity, session 8	1.0	1.2	2.7	1.6	1.1	-0.7	-0.7
Locomotion distance, session 8	0.6	0.9	1.4	0.9	-0.3	-1.2	-1.2
Degree of sensitization distance	0.4	0.4	0.6	-0.5	0.3	0.8	0.8
Degree of sensitization stereotypy	0.8	0.8	2.4	1.0	1.6	0.2	0.2
Conditioned locomotion	1.5	1.7	2.5	1.6	0.3	-1.5	-1.5
Cocaine response after cond. corrected	0.0	0.1	0.1	0.1	-0.1	-0.3	-0.3
Cocaine response after cond. not corrected	1.0	1.2	2.8	-0.2	-1.7	-0.9	-0.9
Cocaine response before conditioning	2.5	3.0	9.3	-1.4	-3.0	-0.7	-0.7
Saline control response	0.0	0.1	0.1	0.3	0.2	-0.2	-0.2
Bone: connectivity density	0.3	0.5	1.5	0.7	1.2	0.0	0.0
Bone: cortical apparent density	2.4	3.3	5.2	2.3	1.4	-1.7	-1.7
Bone: cortical area	1.6	2.4	4.2	-0.0	2.1	1.6	1.6
Bone: cortical porosity	0.3	0.3	0.7	0.7	0.8	0.1	0.1
Bone: cortical porosity	0.1	0.1	0.2	0.4	0.3	0.2	0.2
Bone: cortical thickness	0.7	1.1	3.2	1.0	1.8	0.3	0.3
Bone: cortical thickness	0.3	0.3	0.7	0.7	0.8	-0.2	-0.2
Bone: cortical tissue density	2.3	3.2	5.0	2.2	1.3	-1.7	-1.7
Condit. Reinf. active minus inactive responses	1.0	1.1	1.6	-0.2	-1.3	-1.2	-1.2
Condit. Reinf. active-inactive response ratio	1.1	1.2	3.2	-0.9	-1.8	-0.5	-0.5
Condit. Reinf. active responses	1.3	1.6	2.6	0.6	-0.9	-1.6	-1.6
Condit. Reinf. inactive responses	1.4	1.7	2.8	1.7	0.9	-1.2	-1.2
Incentive salience index mean	1.5	1.8	2.9	0.5	-1.2	-1.7	-1.7
Condit. Reinf. lever presses	1.1	1.6	2.4	0.9	-0.8	-1.6	-1.6
Condit. Reinf. active minus inactive responses	0.4	0.5	0.7	0.7	0.1	-0.8	-0.8
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	0.3	0.5	-0.0	-0.0
Condit. Reinf. active responses	0.1	0.2	0.2	-0.0	-0.5	-0.5	-0.5
Condit. Reinf. inactive responses	0.4	0.6	1.5	-0.5	-1.2	-0.5	-0.5
Condit. Reinf. lever presses	1.3	1.7	3.4	-1.8	-1.7	0.6	0.6
Condit. Reinf. lever reinforcers received	0.3	0.4	0.5	0.0	-0.6	-0.7	-0.7
Conditioned reinforcement - actives	0.1	0.1	0.2	0.3	0.1	-0.4	-0.4
Conditioned reinforcement - inactives	1.7	2.5	4.3	1.0	-0.5	-2.1	-2.1
Conditioned locomotion	0.0	0.1	0.1	0.2	-0.2	-0.3	-0.3
Patch foraging indifference point 0 sec	4.9	9.1	13.6	3.7	1.1	-3.3	-3.3
Patch foraging indifference point AUC	5.9	8.5	12.0	3.2	0.0	-3.5	-3.5
Delay disc. indifference point, 0s delay	0.1	0.2	0.4	0.4	0.7	-0.1	-0.1
Delay disc. indifference point, 16s delay	0.8	0.9	2.1	-1.5	-0.8	0.7	0.7
Delay disc. indifference point, 2s delay	2.9	3.2	5.2	-2.3	-0.4	1.9	1.9
Delay disc. indifference point, 24s delay	0.5	0.6	1.2	-1.1	-1.0	0.1	0.1
Delay disc. indifference point, 4s delay	0.1	0.1	0.5	-0.7	-0.1	0.1	0.1
Delay disc. indifference point, 8s delay	0.1	0.1	0.5	-0.7	0.0	0.1	0.1
Indifference point function ln k	0.5	0.8	1.7	0.2	1.3	0.9	0.9
Indifference point function log k	0.5	0.8	1.7	0.2	1.3	0.9	0.9
Patch foraging total patch changes 0 sec	5.4	10.1	15.8	4.0	1.2	-3.4	-3.4
Patch foraging total patch changes 12 sec	5.7	7.4	11.4	2.6	-0.1	-3.4	-3.4
Patch foraging total patch changes 18 sec	2.9	4.4	6.7	2.1	0.0	-2.6	-2.6
Patch foraging total patch changes 24 sec	1.7	2.9	4.3	1.6	-0.5	-2.1	-2.1
Patch foraging total patch changes 6 sec	6.1	9.3	13.0	3.6	0.6	-3.5	-3.5
Patch foraging time to switch 0 sec	5.5	11.2	19.6	-4.4	-1.8	3.3	3.3
Patch foraging water rate 0 sec	7.0	14.6	27.9	5.3	3.2	-3.2	-3.2
Patch foraging water rate 12 sec	2.4	5.1	8.1	2.8	1.3	-2.3	-2.3
Patch foraging water rate 18 sec	1.6	2.5	4.7	2.2	0.9	-1.5	-1.5
Patch foraging water rate 24 sec	2.7	3.8	5.5	2.0	-0.4	-2.4	-2.4
Patch foraging water rate 6 sec	1.7	2.4	5.2	2.3	1.6	-1.0	-1.0
Seeking ratio, delayed vs. immediate footshock	0.4	0.5	0.8	0.5	-0.4	-0.9	-0.9
Distance traveled before self-admin	0.6	0.8	2.4	-0.6	-1.5	-0.4	-0.4
Distance traveled after self-admin	0.1	0.1	0.2	0.1	0.5	0.2	0.2
Extensor digitorum longus weight	4.5	17.7	35.5	6.0	4.2	-3.0	-3.0
Bone: elastic displacement	0.5	0.6	0.8	-0.4	0.8	0.9	0.9
Bone: elastic work	0.8	1.1	1.5	-1.1	0.3	1.2	1.2
Bone: endosteal estimation	2.1	4.6	6.6	-2.3	0.2	2.6	2.6
Bone: endosteal perimeter	0.8	1.8	2.9	-1.1	0.6	1.7	1.7
Epididymis fat weight	0.8	2.7	5.4	-2.3	-2.3	0.1	0.1
Delta time in closed arm before/after self-admin	0.4	0.4	1.1	0.2	-1.1	-0.4	-0.4
Delta time in open arm before/after self-admin	0.6	0.6	1.1	1.0	0.8	-0.5	-0.5
Diff in mean of infusions in LGA sessions	0.9	1.1	1.7	1.0	0.1	-1.3	-1.3
Delay discount exponential model param	0.4	0.5	1.5	1.2	0.3	-0.4	-0.4
Extinction: sum of active levers before priming	0.1	0.1	0.2	0.2	0.5	0.1	0.1
Active lever presses in extinction session 6	1.0	1.0	1.5	1.2	0.8	-1.0	-1.0
Bone: final force	2.3	3.7	5.8	-1.1	1.4	2.4	2.4
Bone: final moment	2.7	4.3	6.5	-0.9	1.8	2.6	2.6
Food consumed during 24 hour testing period	0.4	0.6	1.0	1.0	0.6	-0.6	-0.6
Glucose	1.2	1.9	3.1	-0.4	1.7	1.5	1.5
Heart weight	0.3	0.5	1.5	0.5	1.2	0.3	0.3
Delay discount hyperbolic model param	0.5	0.6	1.7	1.3	0.2	-0.6	-0.6
Intermittent access intake day 1-15 change	0.6	1.2	2.3	-1.5	-1.5	0.3	0.3
Intermittent access intake escalation	0.5	1.1	2.4	-1.5	-1.4	0.1	0.1
Intermittent access intake escalation 2	0.4	0.4	0.9	-1.0	-0.3	0.5	0.5
Intermitt. access day 1 inactive lever presses	0.3	1.0	1.3	1.1	0.1	-1.1	-1.1
Intermitt. access day 15 inactive lever presses	1.3	2.7	3.4	1.9	1.3	-1.7	-1.7
Intermitt. access escalation Index	0.2	0.3	0.5	0.6	-0.3	-0.7	-0.7
Intermittent access day 1 total infusions	0.1	0.1	0.2	-0.1	-0.3	-0.5	-0.5
Intermittent access day 15 total infusions	0.4	0.5	1.2	-1.1	-1.0	-0.1	-0.1
Intermittent access terminal intake (last 3 days)	0.4	0.5	1.5	-1.2	-0.7	-0.1	-0.1
Intermittent access total infusions	0.1	0.1	0.3	-0.5	-0.4	-0.2	-0.2
Intermittent access day 1 locomotion	0.4	0.5	1.5	-0.4	-1.2	-0.4	-0.4
Intermittent access day 15 total locomotion	0.6	1.0	3.1	-0.8	-1.8	-0.4	-0.4
Intermittent access total locomotion	0.3	0.3	1.1	-0.2	-1.0	-0.3	-0.3
Intermittent access standard deviation	0.4	0.9	1.2	-0.0	-1.0	-1.1	-1.1
Left kidney weight	1.3	6.1	11.3	3.4	2.2	-2.0	-2.0
Right kidney weight	1.0	4.7	8.5	2.9	1.2	-2.1	-2.1
Cocaine induced anxiety	0.7	1.0	2.7	0.7	1.6	0.6	0.6
Post-drug Anxiety	1.1	1.2	3.4	1.1	1.9	0.2	0.2
Baseline Anxiety	0.0	0.1	0.1	-0.3	-0.3	0.0	0.0
Tail length	2.7	10.7	19.6	4.4	3.9	-1.9	-1.9
Length with tail	5.3	23.1	42.0	6.5	4.6	-3.8	-3.8
Length without tail	3.4	11.0	20.1	4.5	2.7	-2.9	-2.9
Times rat made contact with spout	0.7	0.8	1.3	0.7	-0.1	-1.2	-1.2
Lifetime Intake	0.1	0.1	0.4	-0.7	-0.3	-0.0	-0.0
Liver weight, left	2.1	3.5	6.3	2.5	1.7	-1.6	-1.6
Liver weight, right	1.2	2.1	2.9	0.6	-1.5	-1.7	-1.7
Locomotor activity	0.1	0.1	0.2	0.4	0.0	-0.3	-0.3
Locomotor testing distance	0.1	0.1	0.2	0.3	-0.1	-0.4	-0.4
Locomotor testing rearing	1.0	1.9	4.8	-1.7	-2.2	0.2	0.2
Locomotion in novel chamber	0.9	1.2	2.6	1.3	1.6	-0.6	-0.6
Locomotion in novel chamber post-restriction	0.2	0.2	0.4	-0.4	0.2	0.6	0.6
Fecal boli incidents, locomotor time 1	0.1	0.1	0.2	-0.3	-0.3	-0.4	-0.4
Change in fecal boli incidents, locomotor task	0.3	0.3	0.7	0.9	0.4	-0.3	-0.3
Time >=10cm from walls, locomotor time 1	4.5	4.8	7.1	2.0	-0.9	-2.7	-2.7
Bouts of movement, locomotor time 1	0.4	0.5	1.4	-1.2	-0.1	0.4	0.4
Total resting periods, locomotor time 1	0.6	0.7	2.0	-1.4	0.1	0.6	0.6
Rest time, locomotor task time 1	0.2	0.3	0.9	-0.9	-0.3	0.1	0.1
Distance moved, locomotor task time 1	0.8	1.3	2.1	-0.8	-0.4	1.4	1.4
Vertical activity count, locomotor time 1	0.0	0.1	0.2	0.0	-0.4	0.3	0.3
Time >=10cm from walls, locomotor time 2	1.0	1.5	3.2	1.8	0.5	-1.1	-1.1
Bouts of movement, locomotor time 2	0.8	1.4	2.2	-0.6	1.5	1.2	1.2
Total resting periods, locomotor time 2	0.5	0.9	1.3	-0.6	1.1	1.0	1.0
Rest time, locomotor task time 2	0.2	0.2	0.3	-0.3	-0.3	-0.6	-0.6
Distance moved, locomotor task time 2	0.8	1.0	1.6	-0.6	-0.4	1.3	1.3
Vertical activity count, locomotor time 2	0.1	0.1	0.2	0.5	-0.2	0.4	0.4
Light reinforcement 1	0.0	0.1	0.1	0.2	-0.4	-0.2	-0.2
Light reinforcement 2	0.5	0.8	2.3	-1.0	-1.5	0.3	0.3
Bone: marrow area	2.1	4.5	6.5	-2.2	0.2	2.5	2.5
Bone: maximum diameter	0.9	1.6	2.6	-0.8	0.7	1.6	1.6
Bone: maximum force	1.5	2.7	3.8	-0.6	1.6	1.9	1.9
Bone: maximum moment	1.8	3.2	4.3	-0.5	2.0	2.1	2.1
Mean time between licks in bursts	0.2	0.5	0.7	-0.8	-0.5	0.7	0.7
Mean num. licks in bursts	1.5	2.3	3.2	1.7	0.1	-1.8	-1.8
Cd content in liver	0.2	0.2	0.3	-0.3	0.3	0.5	0.5
Co content in liver	1.2	1.4	4.8	0.5	2.2	0.6	0.6
Cu content in liver	0.7	0.8	1.7	-1.3	-1.2	0.2	0.2
Fe content in liver	0.3	0.4	0.9	-0.9	-1.0	-0.1	-0.1
K content in liver	0.4	0.4	0.8	0.9	0.4	-0.5	-0.5
Mg content in liver	0.1	0.1	0.2	0.2	0.4	0.0	0.0
Mn content in liver	0.6	0.7	1.1	-0.2	0.6	1.0	1.0
Na content in liver	0.6	0.6	1.8	-0.3	-1.3	-0.6	-0.6
Rb content in liver	0.1	0.2	0.6	0.3	0.7	0.0	0.0
Se content in liver	0.4	0.5	1.1	-0.2	-1.0	-0.6	-0.6
Sr content in liver	0.8	0.7	1.5	-0.2	-1.2	-0.8	-0.8
Zn content in liver	0.2	0.2	0.3	0.2	0.4	-0.6	-0.6
Bone: minimum diameter	1.5	2.8	5.7	0.3	2.4	1.7	1.7
Time in familiar zone, hab. session 1	0.3	0.3	0.4	-0.1	0.7	0.6	0.6
Time in novel zone, hab. session 1	0.6	0.6	1.9	-0.8	-1.4	-0.1	-0.1
Total zone transitions, hab. session 1	0.3	0.4	0.8	-0.9	-0.8	0.2	0.2
Total locomotion distance, hab. session 1	0.0	0.0	0.0	0.0	-0.1	-0.2	-0.2
Locomotion velocity, hab. session 1	0.2	0.3	0.5	0.6	0.2	-0.7	-0.7
Time in familiar zone, hab. session 2	0.2	0.3	0.6	0.8	0.4	-0.4	-0.4
Time in novel zone, hab. session 2	0.6	0.6	1.3	-1.2	-0.4	0.6	0.6
Total zone transitions, hab. session 2	1.1	1.4	1.8	-0.1	-1.3	-1.4	-1.4
Total locomotion distance, hab. session 2	0.7	0.9	1.5	0.6	-0.2	-1.2	-1.2
Locomotion velocity, hab. session 2	0.6	0.8	1.3	0.7	0.1	-1.1	-1.1
Novel to familiar place preference ratio	0.4	0.5	1.0	-0.9	-1.0	0.0	0.0
Novelty place preference	0.4	0.5	1.1	-1.0	-0.8	0.3	0.3
Time in novel zone, NPP test	0.2	0.2	0.5	-0.6	-0.7	-0.1	-0.1
Total zone transitions, NPP test	2.8	4.1	6.7	1.3	-1.1	-2.6	-2.6
Total locomotion distance, NPP test	1.7	2.3	3.8	1.0	-0.7	-2.0	-2.0
Locomotion velocity, NPP test	0.9	1.3	2.2	0.7	-0.5	-1.5	-1.5
Intraocular pressure	0.1	0.2	0.6	-0.7	0.1	0.2	0.2
Delta distance traveled before/after self-admin	1.0	1.1	1.6	-0.1	1.3	1.1	1.1
Delta ambulatory time before/after self-admin	1.0	1.3	3.3	0.3	1.8	0.9	0.9
Parametrial fat weight	0.2	0.5	1.0	0.3	-1.0	-0.7	-0.7
Pavlov. Cond. lever latency	1.5	1.8	2.6	-0.2	1.6	1.5	1.5
Pavlov. Cond. magazine entry latency	0.6	0.8	1.1	-0.1	1.1	1.0	1.0
Pavlov. Cond. change in total contacts	0.1	0.1	0.1	0.2	-0.1	-0.3	-0.3
Pavlov. Cond. index score	0.0	0.0	0.0	0.0	-0.1	-0.1	-0.1
Pavlov. Cond. latency score	0.0	0.1	0.1	0.0	-0.3	-0.3	-0.3
Pavlov. Cond. lever contacts	0.8	0.9	2.0	-0.3	-1.4	-0.9	-0.9
Pavlov. Cond. magazine entry number	0.2	0.3	0.4	-0.0	-0.6	-0.6	-0.6
Pavlov. Cond. intertrial magazine entries	4.0	4.8	9.3	3.1	2.3	-1.5	-1.5
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	-0.1	0.2	0.2	0.2
Pavlov. Cond. response bias	0.1	0.1	0.2	0.3	-0.2	-0.4	-0.4
Pavlov. Cond. lever latency	1.5	2.1	4.6	1.9	2.1	-0.1	-0.1
Pavlov. Cond. magazine entry latency	2.9	3.5	9.7	-1.6	-3.1	-0.9	-0.9
Pavlov. Cond. change in total contacts	2.4	3.8	7.8	-2.8	-2.3	1.0	1.0
Pavlov. Cond. index score	2.8	3.7	10.0	-2.1	-3.2	-0.4	-0.4
Pavlov. Cond. latency score	2.8	3.8	10.3	-1.9	-3.2	-0.7	-0.7
Pavlov. Cond. lever contacts	1.8	2.5	5.5	-2.1	-2.3	0.1	0.1
Pavlov. Cond. magazine entry number	1.9	2.3	5.8	1.8	2.4	0.3	0.3
Pavlov. Cond. intertrial magazine entries	1.9	2.9	5.4	2.3	2.0	-1.0	-1.0
Pavlov. Cond. lever-magazine prob. diff.	3.1	4.1	11.0	-2.3	-3.3	-0.4	-0.4
Pavlov. Cond. response bias	1.8	2.5	5.6	-2.1	-2.4	0.1	0.1
Time in closed arm before self-admin	3.3	4.2	8.5	-2.9	-1.6	1.7	1.7
Time in closed arm after self-admin	3.1	3.3	6.0	-2.5	-2.1	1.2	1.2
Time in open arm before self-admin	3.7	4.0	6.1	2.5	0.6	-2.2	-2.2
Time in open arm after self-admin	5.8	6.3	11.6	3.4	1.5	-2.4	-2.4
Bone: periosteal estimation	1.9	4.1	6.2	-1.4	1.4	2.5	2.5
Bone: periosteal perimeter	0.4	0.8	1.2	-0.4	0.7	1.1	1.1
Bone: post-yield work	1.3	1.9	5.3	1.5	2.3	0.2	0.2
Progressive ratio test 1 active lever presses	0.1	0.2	0.4	-0.6	-0.6	-0.0	-0.0
Progressive ratio test 1 breakpoint	0.2	0.2	0.4	-0.6	-0.6	-0.1	-0.1
Progressive ratio test 1 inactive lever presses	0.8	1.2	1.8	1.3	1.1	-1.0	-1.0
Progressive ratio test 2 active lever presses	0.7	0.8	2.2	-0.6	-1.5	-0.6	-0.6
Progressive ratio test 2 breakpoint	0.7	0.8	2.2	-0.6	-1.5	-0.6	-0.6
Progressive ratio test 2 inactive lever presses	0.4	0.7	1.1	-0.1	-0.9	-1.0	-1.0
Incentive Sensitization - Responses	0.6	0.9	2.7	-0.5	-1.7	-0.6	-0.6
Incentive Sensitization - Breakpoint	0.6	0.8	2.5	-0.5	-1.6	-0.5	-0.5
Sum of active levers in priming session hrs 5-6	0.5	0.5	0.9	0.9	0.7	-0.5	-0.5
Progressive ratio	0.8	1.3	2.8	-1.7	-0.1	1.1	1.1
Food seeking constrained by brief footshock	0.5	0.6	1.8	-0.2	1.3	0.6	0.6
Seeking ratio, punishment vs. effort	0.4	0.6	1.2	1.1	1.1	-0.3	-0.3
Retroperitoneal fat weight	0.0	0.1	0.2	-0.3	-0.2	-0.4	-0.4
Reaction time number correct	1.5	2.9	6.9	2.2	2.6	-0.1	-0.1
Reaction time mean minus median	0.0	0.0	0.1	-0.2	0.2	0.2	0.2
Reaction time mean minus median AUC	0.4	1.0	1.4	-0.4	1.2	1.1	1.1
Reaction time num false alarms	1.2	1.6	2.8	1.7	0.7	-1.3	-1.3
Reaction time num false alarms AUC	0.8	1.3	2.7	1.6	1.1	-0.8	-0.8
Reaction time trials correct on left	1.5	2.9	6.9	2.2	2.6	-0.1	-0.1
Reaction time trials on left	1.6	2.9	7.0	2.2	2.6	-0.1	-0.1
Reaction time mean	1.3	2.1	3.1	-1.8	-0.2	1.6	1.6
Reaction time mean AUC	0.9	1.4	1.9	-1.4	-0.1	1.4	1.4
Median of all reaction times	1.6	2.3	3.1	-1.7	-0.2	1.7	1.7
Reaction time omissions	0.1	0.1	0.4	0.4	0.6	0.1	0.1
Reaction time false alarm rate	0.3	0.4	0.7	0.5	-0.3	-0.8	-0.8
Reaction time premature initiation rate	0.1	0.2	0.3	0.4	0.6	-0.2	-0.2
Reaction time premature initiations	0.9	1.6	3.7	1.6	1.9	-0.2	-0.2
Std. dev. reaction times	0.8	1.5	2.0	-1.4	0.2	1.4	1.4
Reaction time trials completed	1.6	2.9	7.0	2.2	2.6	-0.1	-0.1
Reaction time trials AUC	1.5	2.9	6.5	2.2	2.5	-0.2	-0.2
Run reversals in cocaine runway, females	1.8	1.8	2.3	-1.5	0.3	1.5	1.5
Run reversals in cocaine runway, males	0.0	0.0	0.1	-0.2	-0.2	0.1	0.1
Latency to leave start box in cocaine runway	0.5	0.6	1.4	-1.2	-0.9	0.2	0.2
Latency to leave start box in cocaine runway, F	0.4	0.4	1.1	-0.8	-1.0	0.2	0.2
Latency to leave start box in cocaine runway, M	0.2	0.2	0.7	-0.8	-0.3	-0.1	-0.1
Std. dev. time between licks in bursts	0.1	0.2	0.3	0.1	0.6	0.4	0.4
Total sessions with >9 infusions	0.6	0.7	1.6	-1.3	-0.5	0.7	0.7
Short access day 1 total inactive lever presses	0.8	1.0	1.6	0.1	-0.9	-1.2	-1.2
Short access day 10 total inactive lever presses	0.3	0.8	1.4	0.6	-0.3	-1.2	-1.2
Short access day 1 total infusions	0.1	0.1	0.2	-0.4	-0.2	-0.2	-0.2
Short access day 10 total infusions	0.2	0.3	0.9	-0.9	-0.1	0.4	0.4
Short access total infusions	0.6	0.7	1.7	-1.3	-0.5	0.7	0.7
Short access day 1 locomotion	0.4	0.4	1.3	-1.1	-0.7	0.2	0.2
Short access day 10 total locomotion	0.1	0.2	0.5	-0.6	-0.7	-0.1	-0.1
Short access total locomotion	0.7	0.8	1.9	-0.5	-1.4	-0.7	-0.7
One hour access (0.3 mA shock)	1.2	1.4	2.3	0.8	-0.5	-1.5	-1.5
Compulsive drug intake	2.5	2.9	4.1	1.6	-0.9	-2.0	-2.0
One hour access (shock baseline)	0.1	0.1	0.4	-0.3	0.6	0.2	0.2
Social response proportion	0.5	0.6	0.9	-0.8	-0.3	0.9	0.9
Social responses	0.3	0.4	0.7	-0.8	-0.3	0.6	0.6
Social time	0.2	0.2	0.4	-0.3	0.6	0.5	0.5
Soleus weight	1.4	4.0	6.7	2.6	0.7	-2.1	-2.1
Bone: stiffness	0.3	0.5	1.4	0.8	1.2	0.0	0.0
Tibialis anterior weight	0.5	1.8	2.7	1.6	0.7	-1.4	-1.4
Time to tail flick, vehicle, before self-admin	2.1	2.1	3.4	1.3	-0.3	-1.9	-1.9
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.2	0.3	-0.3	-0.4	-0.4
Time to tail flick, test, before self-admin	0.3	0.3	1.0	-1.0	-0.3	0.4	0.4
Time to tail flick, test, after self-admin	1.8	1.9	2.6	1.6	0.1	-1.6	-1.6
Delta time to tail flick, vehicle, before/after SA	0.8	0.8	1.4	0.2	1.2	0.9	0.9
Delta time to tail flick, test, before/after SA	2.0	2.1	3.4	1.8	0.3	-1.6	-1.6
Tibia length	0.1	0.2	0.5	0.7	0.2	-0.3	-0.3
Ambulatory time before self-admin	1.1	1.6	4.3	-0.5	-2.1	-0.9	-0.9
Ambulatory time after self-admin	0.0	0.1	0.2	-0.2	-0.4	0.0	0.0
Bone: tissue strength	1.2	1.2	1.7	-0.6	1.0	1.3	1.3
Total heroin consumption	3.0	3.5	6.3	2.5	1.3	-1.8	-1.8
Bone: trabecular number	0.3	0.5	1.5	0.6	1.2	0.2	0.2
Bone: trabecular spacing	0.2	0.3	0.5	-0.4	-0.0	0.7	0.7
Bone: trabecular thickness	0.2	0.2	0.3	0.2	-0.5	-0.6	-0.6
Bone: trabecular tissue density	0.0	0.0	0.1	-0.1	-0.4	0.0	0.0
Water consumed over 24 hours	1.0	1.4	2.0	1.2	0.0	-1.4	-1.4
Number of responses in last shaping day	0.1	0.1	0.2	-0.4	0.4	0.1	0.1