Mta1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Mta1 0.02 0.02 5.5e-03 0.04 0.02 0.03 0.03 6.9e-05 3.8e-03 4.8e-04 6.6e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1
Bone: apparent density0.00.00.0-0.1
Area under the delay curve1.31.41.41.2
BMI with tail1.03.43.41.8
BMI without tail0.61.31.31.1
Body weight1.77.07.0-2.6
Weight adjusted by age0.00.00.0-0.1
Bone surface0.40.70.70.9
Bone volume0.30.50.50.7
Breakpoint value in progressive ratio session0.00.00.0-0.1
Number of licking bursts1.51.81.81.3
Context. condit. distance diff. score3.94.74.7-2.2
Locomotion velocity, session 10.10.10.1-0.3
Locomotion distance, session 10.10.20.20.4
Locomotion velocity, session 20.60.70.70.8
Locomotion distance, session 20.71.01.01.0
Locomotion velocity, session 30.30.40.40.6
Locomotion distance, session 30.10.10.10.4
Stereotopy head waving bouts, day 30.00.00.00.0
Stereotopy head waving duration, day 30.00.00.00.1
Locomotion velocity, session 70.10.10.1-0.2
Locomotion distance, session 70.91.11.11.1
Stereotopy head waving bouts, day 71.92.22.2-1.5
Stereotopy head waving duration, day 71.21.51.5-1.2
Locomotion velocity, session 82.83.43.4-1.8
Locomotion distance, session 80.50.70.7-0.8
Degree of sensitization distance0.20.20.20.4
Degree of sensitization stereotypy0.90.90.9-1.0
Conditioned locomotion1.51.81.8-1.3
Cocaine response after cond. corrected0.00.00.0-0.2
Cocaine response after cond. not corrected0.10.10.10.2
Cocaine response before conditioning1.72.02.01.4
Saline control response0.00.00.0-0.0
Bone: connectivity density0.40.60.6-0.8
Bone: cortical apparent density4.15.45.4-2.3
Bone: cortical area0.00.00.0-0.2
Bone: cortical porosity0.20.20.2-0.4
Bone: cortical porosity0.20.20.2-0.5
Bone: cortical thickness0.61.01.0-1.0
Bone: cortical thickness0.30.30.3-0.6
Bone: cortical tissue density4.05.35.3-2.3
Condit. Reinf. active minus inactive responses0.20.20.20.4
Condit. Reinf. active-inactive response ratio1.21.31.31.1
Condit. Reinf. active responses0.10.10.1-0.4
Condit. Reinf. inactive responses1.82.22.2-1.5
Incentive salience index mean0.00.00.0-0.2
Condit. Reinf. lever presses0.40.50.5-0.7
Condit. Reinf. active minus inactive responses0.20.30.3-0.5
Condit. Reinf. active-inactive response ratio0.00.00.0-0.2
Condit. Reinf. active responses0.00.00.0-0.0
Condit. Reinf. inactive responses0.10.10.10.3
Condit. Reinf. lever presses2.02.72.71.6
Condit. Reinf. lever reinforcers received0.00.00.0-0.0
Conditioned reinforcement - actives0.40.40.4-0.6
Conditioned reinforcement - inactives0.10.10.1-0.4
Conditioned locomotion0.10.10.10.3
Patch foraging indifference point 0 sec4.26.86.8-2.6
Patch foraging indifference point AUC7.68.88.8-3.0
Delay disc. indifference point, 0s delay0.40.50.5-0.7
Delay disc. indifference point, 16s delay1.51.51.51.2
Delay disc. indifference point, 2s delay4.85.35.32.3
Delay disc. indifference point, 24s delay0.70.60.60.8
Delay disc. indifference point, 4s delay0.91.01.01.0
Delay disc. indifference point, 8s delay0.40.40.40.6
Indifference point function ln k0.10.20.2-0.4
Indifference point function log k0.10.20.2-0.4
Patch foraging total patch changes 0 sec5.58.98.9-3.0
Patch foraging total patch changes 12 sec2.22.92.9-1.7
Patch foraging total patch changes 18 sec1.82.32.3-1.5
Patch foraging total patch changes 24 sec1.01.21.2-1.1
Patch foraging total patch changes 6 sec5.17.57.5-2.7
Patch foraging time to switch 0 sec11.617.917.94.2
Patch foraging water rate 0 sec15.825.425.4-5.0
Patch foraging water rate 12 sec5.68.68.6-2.9
Patch foraging water rate 18 sec3.14.24.2-2.0
Patch foraging water rate 24 sec2.83.83.8-2.0
Patch foraging water rate 6 sec4.56.66.6-2.6
Seeking ratio, delayed vs. immediate footshock0.20.20.2-0.5
Distance traveled before self-admin0.60.60.60.8
Distance traveled after self-admin0.20.20.2-0.5
Extensor digitorum longus weight9.236.436.4-6.0
Bone: elastic displacement0.00.00.0-0.0
Bone: elastic work0.70.90.91.0
Bone: endosteal estimation2.04.44.42.1
Bone: endosteal perimeter0.61.21.21.1
Epididymis fat weight1.53.43.41.8
Delta time in closed arm before/after self-admin0.30.30.3-0.5
Delta time in open arm before/after self-admin0.60.50.5-0.7
Diff in mean of infusions in LGA sessions0.20.20.2-0.4
Delay discount exponential model param1.11.11.1-1.1
Extinction: sum of active levers before priming0.00.00.0-0.2
Active lever presses in extinction session 60.20.20.2-0.5
Bone: final force0.50.80.80.9
Bone: final moment0.30.50.50.7
Food consumed during 24 hour testing period0.70.90.9-0.9
Glucose0.10.10.10.3
Heart weight0.91.31.31.1
Delay discount hyperbolic model param1.61.71.7-1.3
Intermittent access intake day 1-15 change1.11.11.11.0
Intermittent access intake escalation1.11.11.11.1
Intermittent access intake escalation 20.20.20.20.4
Intermitt. access day 1 inactive lever presses2.83.03.0-1.7
Intermitt. access day 15 inactive lever presses0.30.30.3-0.6
Intermitt. access escalation Index0.00.00.00.1
Intermittent access day 1 total infusions0.00.00.0-0.1
Intermittent access day 15 total infusions0.91.01.01.0
Intermittent access terminal intake (last 3 days)1.71.91.91.4
Intermittent access total infusions0.20.20.20.5
Intermittent access day 1 locomotion0.00.00.00.1
Intermittent access day 15 total locomotion0.00.00.00.2
Intermittent access total locomotion0.00.00.00.0
Intermittent access standard deviation0.30.30.30.6
Left kidney weight3.18.68.6-2.9
Right kidney weight1.02.82.8-1.7
Cocaine induced anxiety0.10.10.1-0.3
Post-drug Anxiety0.10.10.1-0.3
Baseline Anxiety0.30.30.30.6
Tail length4.112.512.5-3.5
Length with tail8.531.231.2-5.6
Length without tail6.113.313.3-3.7
Times rat made contact with spout0.10.10.1-0.3
Lifetime Intake0.30.30.30.6
Liver weight, left3.45.55.5-2.3
Liver weight, right0.61.01.0-1.0
Locomotor activity0.10.20.2-0.5
Locomotor testing distance0.10.10.1-0.4
Locomotor testing rearing1.52.42.41.5
Locomotion in novel chamber2.32.82.8-1.7
Locomotion in novel chamber post-restriction0.10.20.20.4
Fecal boli incidents, locomotor time 10.00.00.00.1
Change in fecal boli incidents, locomotor task2.32.22.2-1.5
Time >=10cm from walls, locomotor time 13.94.04.0-2.0
Bouts of movement, locomotor time 11.21.31.31.2
Total resting periods, locomotor time 11.21.31.31.2
Rest time, locomotor task time 10.40.40.40.7
Distance moved, locomotor task time 10.60.70.70.8
Vertical activity count, locomotor time 10.00.00.00.1
Time >=10cm from walls, locomotor time 21.61.71.7-1.3
Bouts of movement, locomotor time 21.21.31.31.1
Total resting periods, locomotor time 21.21.31.31.1
Rest time, locomotor task time 20.00.00.0-0.1
Distance moved, locomotor task time 20.40.50.50.7
Vertical activity count, locomotor time 20.10.10.10.3
Light reinforcement 10.00.00.0-0.2
Light reinforcement 20.40.60.60.7
Bone: marrow area2.04.34.32.1
Bone: maximum diameter0.30.60.60.8
Bone: maximum force0.10.20.20.5
Bone: maximum moment0.00.10.10.3
Mean time between licks in bursts0.40.60.60.8
Mean num. licks in bursts1.61.91.9-1.4
Cd content in liver0.50.50.5-0.7
Co content in liver1.01.21.2-1.1
Cu content in liver2.53.13.11.8
Fe content in liver1.21.41.41.2
K content in liver2.22.22.2-1.5
Mg content in liver0.60.60.6-0.8
Mn content in liver0.30.30.3-0.6
Na content in liver0.00.10.1-0.2
Rb content in liver0.10.10.1-0.4
Se content in liver0.00.00.0-0.2
Sr content in liver0.20.20.20.4
Zn content in liver0.10.10.10.3
Bone: minimum diameter0.10.20.2-0.5
Time in familiar zone, hab. session 10.10.10.10.3
Time in novel zone, hab. session 10.60.60.60.8
Total zone transitions, hab. session 10.71.01.01.0
Total locomotion distance, hab. session 10.00.00.00.1
Locomotion velocity, hab. session 10.20.30.3-0.6
Time in familiar zone, hab. session 20.60.70.7-0.8
Time in novel zone, hab. session 21.31.31.31.1
Total zone transitions, hab. session 20.20.20.20.5
Total locomotion distance, hab. session 20.10.10.1-0.3
Locomotion velocity, hab. session 20.20.20.2-0.5
Novel to familiar place preference ratio0.80.90.90.9
Novelty place preference1.11.21.21.1
Time in novel zone, NPP test0.40.40.40.7
Total zone transitions, NPP test0.50.70.7-0.8
Total locomotion distance, NPP test0.50.60.6-0.8
Locomotion velocity, NPP test0.20.30.3-0.6
Intraocular pressure0.60.80.80.9
Delta distance traveled before/after self-admin0.30.30.3-0.5
Delta ambulatory time before/after self-admin1.21.31.3-1.1
Parametrial fat weight0.10.30.30.5
Pavlov. Cond. lever latency0.00.00.00.2
Pavlov. Cond. magazine entry latency0.00.00.0-0.1
Pavlov. Cond. change in total contacts0.10.10.1-0.3
Pavlov. Cond. index score0.00.00.0-0.2
Pavlov. Cond. latency score0.00.00.0-0.2
Pavlov. Cond. lever contacts0.10.10.10.3
Pavlov. Cond. magazine entry number0.10.10.10.3
Pavlov. Cond. intertrial magazine entries9.111.011.0-3.3
Pavlov. Cond. lever-magazine prob. diff.0.00.00.0-0.2
Pavlov. Cond. response bias0.10.10.1-0.3
Pavlov. Cond. lever latency3.24.34.3-2.1
Pavlov. Cond. magazine entry latency4.34.94.92.2
Pavlov. Cond. change in total contacts7.310.010.03.2
Pavlov. Cond. index score5.36.86.82.6
Pavlov. Cond. latency score4.65.75.72.4
Pavlov. Cond. lever contacts3.34.54.52.1
Pavlov. Cond. magazine entry number4.45.45.4-2.3
Pavlov. Cond. intertrial magazine entries5.57.27.2-2.7
Pavlov. Cond. lever-magazine prob. diff.6.17.87.82.8
Pavlov. Cond. response bias3.64.94.92.2
Time in closed arm before self-admin5.86.56.52.6
Time in closed arm after self-admin4.24.34.32.1
Time in open arm before self-admin5.66.06.0-2.5
Time in open arm after self-admin6.16.76.7-2.6
Bone: periosteal estimation0.71.51.51.2
Bone: periosteal perimeter0.10.20.20.4
Bone: post-yield work1.31.81.8-1.3
Progressive ratio test 1 active lever presses0.10.10.10.4
Progressive ratio test 1 breakpoint0.20.30.30.5
Progressive ratio test 1 inactive lever presses0.91.01.0-1.0
Progressive ratio test 2 active lever presses0.10.10.10.3
Progressive ratio test 2 breakpoint0.00.00.00.1
Progressive ratio test 2 inactive lever presses0.10.10.10.3
Incentive Sensitization - Responses0.10.10.10.4
Incentive Sensitization - Breakpoint0.10.10.10.3
Sum of active levers in priming session hrs 5-60.00.00.00.1
Progressive ratio1.82.12.11.4
Food seeking constrained by brief footshock0.00.00.00.1
Seeking ratio, punishment vs. effort1.01.21.2-1.1
Retroperitoneal fat weight0.10.30.30.5
Reaction time number correct3.95.65.6-2.4
Reaction time mean minus median0.00.00.0-0.1
Reaction time mean minus median AUC0.00.00.0-0.2
Reaction time num false alarms2.02.72.7-1.6
Reaction time num false alarms AUC2.12.92.9-1.7
Reaction time trials correct on left3.95.65.6-2.4
Reaction time trials on left4.05.75.7-2.4
Reaction time mean0.81.21.21.1
Reaction time mean AUC0.40.50.50.7
Median of all reaction times0.81.11.11.0
Reaction time omissions1.01.31.3-1.1
Reaction time false alarm rate0.10.20.2-0.4
Reaction time premature initiation rate0.50.70.7-0.8
Reaction time premature initiations3.04.24.2-2.0
Std. dev. reaction times0.60.90.90.9
Reaction time trials completed4.05.75.7-2.4
Reaction time trials AUC4.26.16.1-2.5
Run reversals in cocaine runway, females2.22.12.11.4
Run reversals in cocaine runway, males0.00.00.00.2
Latency to leave start box in cocaine runway0.91.01.01.0
Latency to leave start box in cocaine runway, F0.10.10.10.4
Latency to leave start box in cocaine runway, M1.01.01.01.0
Std. dev. time between licks in bursts0.00.00.00.0
Total sessions with >9 infusions0.20.20.20.4
Short access day 1 total inactive lever presses0.10.10.10.3
Short access day 10 total inactive lever presses0.20.20.2-0.5
Short access day 1 total infusions0.00.00.00.1
Short access day 10 total infusions0.30.30.30.6
Short access total infusions1.01.11.11.1
Short access day 1 locomotion0.20.30.30.5
Short access day 10 total locomotion0.00.00.00.1
Short access total locomotion0.10.10.10.2
One hour access (0.3 mA shock)0.20.20.2-0.5
Compulsive drug intake0.60.60.6-0.8
One hour access (shock baseline)0.30.40.40.6
Social response proportion0.10.10.10.4
Social responses0.70.90.91.0
Social time0.00.00.0-0.2
Soleus weight2.16.06.0-2.5
Bone: stiffness0.30.50.5-0.7
Tibialis anterior weight0.72.42.4-1.5
Time to tail flick, vehicle, before self-admin3.03.13.1-1.8
Time to tail flick, vehicle, after self-admin1.01.11.1-1.0
Time to tail flick, test, before self-admin1.21.21.21.1
Time to tail flick, test, after self-admin6.26.46.4-2.5
Delta time to tail flick, vehicle, before/after SA0.10.10.1-0.3
Delta time to tail flick, test, before/after SA8.37.57.5-2.7
Tibia length0.10.30.3-0.5
Ambulatory time before self-admin0.91.01.01.0
Ambulatory time after self-admin0.00.00.00.1
Bone: tissue strength0.40.40.40.6
Total heroin consumption1.72.02.0-1.4
Bone: trabecular number0.20.40.4-0.6
Bone: trabecular spacing0.00.00.00.0
Bone: trabecular thickness0.10.10.1-0.4
Bone: trabecular tissue density0.00.00.0-0.2
Water consumed over 24 hours0.70.80.8-0.9
Number of responses in last shaping day0.50.50.50.7