Mstn

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	LHb	gene expression	Mstn	0.23	0.14	9.2e-03	0.01	0.02	-0.01	0.01	2.2e-01	1.2e-01	4.6e-01	2.1e-01
2	Brain	gene expression	Mstn	0.17	0.09	8.8e-12	0.1	0.11	0.08	0.1	6.1e-10	3.4e-10	3.0e-08	1.8e-09
3	OFC	gene expression	Mstn	0.4	0.16	3.8e-05	0.07	0.14	0.14	0.11	9.9e-03	3.1e-04	4.1e-04	1.6e-03
4	Adipose	gene expression	Mstn	0.17	0.07	0.0e+00	0.1	0.15	0.15	0.15	1.0e-11	3.6e-16	5.3e-16	3.6e-16
5	PL	gene expression	Mstn	0.08	0.05	2.9e-06	0.03	0.05	0.04	0.04	2.6e-04	8.4e-06	1.8e-05	2.3e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	1.6	2.7	5.6	-2.4	-1.8	1.4	-1.0	1.4
Area under the delay curve	0.1	0.1	0.2	-0.2	0.1	0.5	0.2	0.3
BMI with tail	2.6	8.4	16.3	3.4	4.0	-1.6	3.3	-1.0
BMI without tail	0.8	1.6	3.7	0.9	1.9	0.1	1.8	0.3
Body weight	0.1	0.4	0.7	0.8	0.1	-0.5	-0.3	-0.8
Weight adjusted by age	1.6	1.8	2.5	0.7	-1.2	-1.4	-1.6	-1.6
Bone surface	0.7	1.2	2.7	-0.5	-1.7	-0.7	-1.6	-0.6
Bone volume	1.2	2.1	4.6	-1.6	-2.1	0.3	-1.7	0.3
Breakpoint value in progressive ratio session	0.4	0.4	0.8	-0.8	-0.6	0.9	-0.4	0.5
Number of licking bursts	1.6	1.9	2.9	-0.9	1.1	1.6	1.5	1.7
Context. condit. distance diff. score	2.7	3.2	5.5	-0.3	2.1	1.7	2.4	1.7
Locomotion velocity, session 1	0.1	0.1	0.2	0.1	0.4	0.4	0.4	0.2
Locomotion distance, session 1	0.2	0.3	0.6	0.8	0.4	-0.5	0.2	-0.6
Locomotion velocity, session 2	1.3	1.5	2.9	1.7	0.9	-1.4	0.4	-1.3
Locomotion distance, session 2	0.9	1.2	2.1	1.4	0.4	-1.5	-0.0	-1.3
Locomotion velocity, session 3	0.1	0.1	0.3	0.3	0.5	-0.0	0.5	0.1
Locomotion distance, session 3	0.5	0.6	1.2	-0.1	1.0	0.5	1.1	0.7
Stereotopy head waving bouts, day 3	0.3	0.4	0.7	0.9	0.6	-0.5	0.4	-0.5
Stereotopy head waving duration, day 3	0.0	0.0	0.1	0.2	0.2	0.1	0.2	-0.1
Locomotion velocity, session 7	1.5	1.7	2.9	1.3	-0.4	-1.7	-0.9	-1.7
Locomotion distance, session 7	1.0	1.3	2.4	1.3	-0.0	-1.4	-0.6	-1.5
Stereotopy head waving bouts, day 7	0.2	0.3	0.5	-0.6	-0.1	0.7	0.0	0.6
Stereotopy head waving duration, day 7	0.4	0.5	0.9	-0.9	-0.7	0.7	-0.5	0.6
Locomotion velocity, session 8	0.4	0.4	0.9	-0.0	0.8	0.4	1.0	0.6
Locomotion distance, session 8	0.9	1.4	3.1	0.7	1.8	0.2	1.7	0.4
Degree of sensitization distance	1.9	1.9	3.2	0.9	-1.0	-1.5	-1.5	-1.8
Degree of sensitization stereotypy	0.5	0.5	0.9	-0.9	-0.2	0.9	0.2	0.9
Conditioned locomotion	0.0	0.1	0.2	-0.1	0.1	0.5	0.1	0.2
Cocaine response after cond. corrected	1.3	1.4	2.6	1.1	-0.5	-1.4	-1.0	-1.6
Cocaine response after cond. not corrected	2.4	2.7	4.3	0.8	-1.6	-1.6	-2.1	-1.9
Cocaine response before conditioning	0.7	0.9	1.9	-0.4	-1.4	-0.4	-1.4	-0.5
Saline control response	0.5	0.7	1.1	-0.6	0.6	0.9	0.9	1.1
Bone: connectivity density	0.2	0.3	0.7	-0.9	-0.6	0.3	-0.3	0.5
Bone: cortical apparent density	3.8	5.1	9.3	3.1	2.5	-2.0	1.7	-1.7
Bone: cortical area	0.9	1.4	2.3	1.0	-0.6	-1.4	-1.1	-1.5
Bone: cortical porosity	1.1	1.2	2.6	-1.6	-1.2	0.9	-0.6	1.0
Bone: cortical porosity	1.3	1.4	2.5	-1.6	-1.6	0.6	-1.1	0.7
Bone: cortical thickness	0.8	1.3	2.5	1.6	1.2	-1.1	0.8	-0.9
Bone: cortical thickness	0.2	0.2	0.3	0.2	-0.4	-0.6	-0.5	-0.6
Bone: cortical tissue density	3.8	5.0	9.2	3.0	2.5	-2.0	1.7	-1.7
Condit. Reinf. active minus inactive responses	2.4	2.7	3.9	-2.0	-1.9	1.6	-1.5	0.9
Condit. Reinf. active-inactive response ratio	1.4	1.5	2.1	-1.5	-1.3	1.3	-1.1	0.7
Condit. Reinf. active responses	1.8	2.2	4.2	-1.5	-2.1	1.0	-1.9	0.2
Condit. Reinf. inactive responses	0.3	0.4	0.7	0.4	-0.5	-0.6	-0.7	-0.8
Incentive salience index mean	2.1	2.6	4.4	-2.1	-1.6	1.8	-1.1	1.2
Condit. Reinf. lever presses	1.0	1.4	2.7	-1.4	-0.3	1.7	0.2	1.4
Condit. Reinf. active minus inactive responses	1.9	2.3	4.7	-1.6	-2.2	0.8	-1.9	0.3
Condit. Reinf. active-inactive response ratio	1.8	1.9	3.3	-1.8	-1.6	1.2	-1.2	0.9
Condit. Reinf. active responses	0.5	0.8	1.7	-0.5	-1.3	0.0	-1.3	-0.3
Condit. Reinf. inactive responses	0.4	0.5	1.0	0.7	-0.3	-0.9	-0.5	-1.0
Condit. Reinf. lever presses	0.1	0.1	0.3	-0.1	-0.5	-0.2	-0.5	-0.2
Condit. Reinf. lever reinforcers received	0.6	0.8	2.0	-0.3	-1.3	-0.2	-1.4	-0.6
Conditioned reinforcement - actives	0.1	0.1	0.3	-0.4	-0.5	0.2	-0.4	0.1
Conditioned reinforcement - inactives	0.5	0.6	1.3	-0.6	-1.1	0.0	-1.1	-0.1
Conditioned locomotion	2.6	3.1	6.0	2.2	0.7	-2.5	-0.0	-2.0
Patch foraging indifference point 0 sec	1.6	2.5	3.8	1.8	1.9	-1.5	1.7	-0.7
Patch foraging indifference point AUC	0.7	0.8	1.9	0.7	-0.4	-1.4	-0.5	-1.0
Delay disc. indifference point, 0s delay	0.1	0.1	0.1	-0.3	-0.1	0.2	0.1	0.3
Delay disc. indifference point, 16s delay	0.4	0.4	0.7	-0.8	-0.5	0.9	-0.3	0.5
Delay disc. indifference point, 2s delay	0.0	0.0	0.0	-0.1	-0.2	-0.2	-0.1	-0.0
Delay disc. indifference point, 24s delay	0.6	0.6	1.1	-0.3	0.7	1.0	0.8	0.9
Delay disc. indifference point, 4s delay	0.2	0.2	0.3	0.5	0.6	-0.3	0.4	-0.2
Delay disc. indifference point, 8s delay	0.2	0.2	0.3	-0.4	-0.5	0.4	-0.5	0.1
Indifference point function ln k	1.3	1.9	3.3	-0.2	1.6	1.2	1.8	1.3
Indifference point function log k	1.3	1.9	3.3	-0.2	1.6	1.2	1.8	1.3
Patch foraging total patch changes 0 sec	1.5	2.5	3.7	1.8	1.9	-1.5	1.7	-0.6
Patch foraging total patch changes 12 sec	0.4	0.6	1.5	0.8	0.1	-1.2	-0.0	-0.8
Patch foraging total patch changes 18 sec	0.7	0.9	1.3	1.1	0.9	-1.2	0.9	-0.5
Patch foraging total patch changes 24 sec	0.4	0.5	1.1	0.8	0.5	-1.1	0.4	-0.5
Patch foraging total patch changes 6 sec	1.4	2.1	2.9	1.7	1.6	-1.6	1.3	-0.8
Patch foraging time to switch 0 sec	0.5	0.7	1.1	-1.1	-0.7	1.0	-0.5	0.7
Patch foraging water rate 0 sec	0.6	0.9	1.5	1.2	1.0	-1.0	0.7	-0.7
Patch foraging water rate 12 sec	0.5	0.7	1.4	0.0	1.1	0.6	1.2	0.7
Patch foraging water rate 18 sec	0.6	0.8	1.4	-0.5	0.7	1.2	0.9	1.1
Patch foraging water rate 24 sec	0.0	0.0	0.1	0.3	0.1	-0.0	-0.1	-0.3
Patch foraging water rate 6 sec	0.9	1.3	2.9	0.2	1.6	0.6	1.7	0.8
Seeking ratio, delayed vs. immediate footshock	1.2	1.4	3.0	-1.2	-1.7	0.3	-1.5	0.1
Distance traveled before self-admin	3.4	3.6	8.5	-1.4	-2.9	-0.3	-2.7	-0.5
Distance traveled after self-admin	0.7	0.8	1.9	-0.4	-1.3	-0.2	-1.4	-0.5
Extensor digitorum longus weight	5.2	20.5	37.6	6.1	2.4	-5.6	0.5	-5.2
Bone: elastic displacement	1.5	1.7	3.0	-1.3	0.5	1.6	1.0	1.7
Bone: elastic work	0.8	1.1	2.1	-1.2	-1.4	0.5	-1.2	0.4
Bone: endosteal estimation	2.6	5.6	12.6	-1.2	-3.5	-0.7	-3.5	-1.1
Bone: endosteal perimeter	1.1	2.2	5.1	-0.6	-2.2	-0.4	-2.3	-0.8
Epididymis fat weight	0.3	0.8	1.9	0.1	-1.1	-0.4	-1.4	-0.8
Delta time in closed arm before/after self-admin	0.8	0.8	1.5	1.2	0.5	-1.2	0.1	-1.0
Delta time in open arm before/after self-admin	2.2	2.1	4.1	-2.0	-1.6	1.3	-1.0	1.2
Diff in mean of infusions in LGA sessions	1.1	1.2	2.1	-1.5	-0.9	1.3	-0.6	1.0
Delay discount exponential model param	0.2	0.2	0.4	0.2	-0.3	-0.6	-0.3	-0.5
Extinction: sum of active levers before priming	0.8	0.7	1.3	-0.9	-1.1	0.7	-1.0	0.3
Active lever presses in extinction session 6	0.7	0.7	1.4	-1.0	-0.2	1.2	0.1	1.0
Bone: final force	1.8	3.0	4.9	0.6	-1.8	-1.7	-2.2	-1.9
Bone: final moment	1.4	2.3	3.3	0.7	-1.4	-1.6	-1.8	-1.8
Food consumed during 24 hour testing period	0.8	1.0	1.7	0.1	-1.2	-0.9	-1.3	-0.9
Glucose	1.1	1.7	3.1	-0.2	1.5	1.2	1.8	1.3
Heart weight	0.2	0.3	0.8	-0.5	-0.9	-0.1	-0.8	-0.1
Delay discount hyperbolic model param	0.1	0.1	0.1	0.0	-0.3	-0.3	-0.3	-0.2
Intermittent access intake day 1-15 change	0.4	0.4	0.9	0.3	0.9	0.3	0.9	0.4
Intermittent access intake escalation	0.3	0.3	0.5	-0.0	0.6	0.6	0.7	0.5
Intermittent access intake escalation 2	0.5	0.5	0.9	-0.4	0.5	1.0	0.7	0.8
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.1	0.2	0.4	-0.3	0.4	-0.0
Intermitt. access day 15 inactive lever presses	0.3	0.3	0.6	-0.8	-0.6	0.5	-0.4	0.4
Intermitt. access escalation Index	0.7	0.6	1.4	0.6	1.2	0.3	1.0	0.2
Intermittent access day 1 total infusions	0.8	0.9	1.7	-1.2	-0.3	1.3	0.1	1.2
Intermittent access day 15 total infusions	1.0	1.2	2.1	-0.8	0.6	1.4	0.9	1.3
Intermittent access terminal intake (last 3 days)	0.9	0.9	1.3	-0.5	0.8	1.1	1.1	1.2
Intermittent access total infusions	0.7	0.8	1.5	-1.0	0.1	1.2	0.4	1.2
Intermittent access day 1 locomotion	0.0	0.0	0.1	-0.3	-0.1	0.1	-0.0	0.2
Intermittent access day 15 total locomotion	0.0	0.0	0.0	0.1	-0.0	-0.1	-0.1	-0.1
Intermittent access total locomotion	0.1	0.2	0.3	0.0	0.5	0.2	0.6	0.4
Intermittent access standard deviation	0.0	0.0	0.1	0.2	0.3	-0.1	0.3	0.0
Left kidney weight	0.1	0.4	0.7	0.5	-0.4	-0.6	-0.6	-0.8
Right kidney weight	0.6	1.7	3.2	1.5	-0.2	-1.7	-0.7	-1.8
Cocaine induced anxiety	2.6	3.0	6.1	2.5	1.7	-1.7	0.9	-1.6
Post-drug Anxiety	1.1	1.2	2.3	1.5	1.4	-0.6	1.0	-0.7
Baseline Anxiety	2.2	2.4	4.5	-2.1	-1.1	1.9	-0.5	1.6
Tail length	1.7	5.2	10.8	-2.3	-3.3	1.1	-3.0	0.3
Length with tail	2.0	7.4	16.8	-2.0	-4.1	0.3	-4.0	-0.6
Length without tail	1.3	2.8	4.2	1.0	-1.4	-1.8	-1.9	-2.1
Times rat made contact with spout	1.8	2.1	3.4	-1.1	0.9	1.7	1.4	1.9
Lifetime Intake	0.2	0.3	0.5	-0.5	0.1	0.7	0.3	0.7
Liver weight, left	1.7	2.7	4.7	1.1	-1.2	-2.2	-1.6	-2.0
Liver weight, right	0.6	1.0	1.5	0.6	-0.8	-1.1	-1.2	-1.2
Locomotor activity	0.0	0.0	0.1	0.2	0.1	-0.3	0.0	-0.2
Locomotor testing distance	0.3	0.5	1.0	-0.9	-0.0	0.8	0.4	1.0
Locomotor testing rearing	1.0	1.5	2.4	-0.4	1.3	1.3	1.5	1.4
Locomotion in novel chamber	2.5	3.1	5.7	2.1	0.3	-2.4	-0.4	-2.2
Locomotion in novel chamber post-restriction	2.1	2.5	4.7	1.9	0.2	-2.2	-0.5	-2.0
Fecal boli incidents, locomotor time 1	0.0	0.0	0.1	-0.0	0.2	0.0	0.3	0.2
Change in fecal boli incidents, locomotor task	0.3	0.3	0.4	-0.2	0.5	0.6	0.6	0.6
Time >=10cm from walls, locomotor time 1	1.0	1.0	1.8	0.9	-0.4	-1.3	-0.9	-1.4
Bouts of movement, locomotor time 1	0.6	0.7	1.3	0.9	1.2	-0.4	1.0	-0.2
Total resting periods, locomotor time 1	0.9	1.0	1.5	1.2	1.2	-0.8	0.9	-0.6
Rest time, locomotor task time 1	0.5	0.6	1.3	0.1	1.0	0.3	1.1	0.6
Distance moved, locomotor task time 1	0.1	0.1	0.2	-0.1	-0.2	0.4	-0.3	-0.0
Vertical activity count, locomotor time 1	0.1	0.1	0.1	0.2	-0.1	-0.2	-0.3	-0.4
Time >=10cm from walls, locomotor time 2	1.1	1.2	2.2	-1.5	-0.9	1.2	-0.5	1.0
Bouts of movement, locomotor time 2	2.0	2.2	3.8	1.9	1.9	-0.9	1.4	-0.8
Total resting periods, locomotor time 2	2.0	2.1	3.8	1.8	1.9	-0.9	1.5	-0.7
Rest time, locomotor task time 2	0.6	0.7	1.9	0.4	1.2	-0.0	1.4	0.4
Distance moved, locomotor task time 2	0.3	0.4	0.8	-0.3	-0.8	0.3	-0.9	-0.2
Vertical activity count, locomotor time 2	0.1	0.1	0.1	0.1	0.3	0.3	0.2	0.1
Light reinforcement 1	2.9	5.2	9.7	3.1	1.8	-2.7	0.9	-2.3
Light reinforcement 2	0.6	0.8	1.5	1.1	0.5	-1.2	0.2	-0.9
Bone: marrow area	2.5	5.3	11.9	-1.1	-3.4	-0.8	-3.4	-1.1
Bone: maximum diameter	0.2	0.4	0.7	0.5	-0.4	-0.7	-0.6	-0.8
Bone: maximum force	2.8	4.9	9.4	0.1	-2.8	-1.8	-3.1	-2.0
Bone: maximum moment	2.2	3.7	6.8	0.2	-2.3	-1.7	-2.6	-1.9
Mean time between licks in bursts	1.7	2.4	4.6	1.9	0.5	-2.1	-0.1	-1.8
Mean num. licks in bursts	0.2	0.2	0.4	0.4	-0.3	-0.7	-0.4	-0.6
Cd content in liver	0.9	1.0	2.1	0.1	-1.3	-0.7	-1.5	-0.9
Co content in liver	1.3	1.5	3.0	-1.3	0.2	1.7	0.6	1.5
Cu content in liver	1.4	1.7	3.0	-1.7	-1.1	1.6	-0.7	1.2
Fe content in liver	1.9	2.3	4.1	-2.0	-1.5	1.5	-1.0	1.2
K content in liver	1.1	1.1	2.6	1.2	0.3	-1.6	0.1	-1.1
Mg content in liver	0.4	0.4	0.7	0.8	0.7	-0.8	0.5	-0.4
Mn content in liver	0.5	0.6	1.3	-0.2	0.9	0.4	1.1	0.8
Na content in liver	0.0	0.0	0.0	0.1	0.1	-0.2	0.2	0.0
Rb content in liver	1.5	1.9	3.4	1.8	0.4	-1.6	-0.2	-1.8
Se content in liver	0.1	0.1	0.2	0.3	0.1	-0.4	0.0	-0.3
Sr content in liver	0.2	0.2	0.4	0.2	0.7	0.3	0.6	0.3
Zn content in liver	0.4	0.4	0.8	0.9	0.7	-0.5	0.5	-0.5
Bone: minimum diameter	1.4	2.6	4.2	0.5	-1.7	-1.6	-2.0	-1.7
Time in familiar zone, hab. session 1	0.6	0.5	1.1	0.2	1.0	0.6	1.0	0.5
Time in novel zone, hab. session 1	2.3	2.2	4.1	-2.0	-1.7	1.4	-1.1	1.1
Total zone transitions, hab. session 1	0.8	1.2	1.6	0.5	-1.0	-1.3	-1.2	-1.2
Total locomotion distance, hab. session 1	2.6	3.7	6.1	0.6	-2.1	-1.9	-2.5	-2.1
Locomotion velocity, hab. session 1	2.5	3.5	5.3	1.2	-1.4	-2.3	-1.9	-2.3
Time in familiar zone, hab. session 2	0.2	0.2	0.3	-0.4	0.2	0.5	0.3	0.5
Time in novel zone, hab. session 2	0.2	0.2	0.3	-0.3	0.3	0.6	0.4	0.5
Total zone transitions, hab. session 2	0.1	0.1	0.2	-0.1	0.3	0.3	0.4	0.3
Total locomotion distance, hab. session 2	0.4	0.6	1.2	0.1	-0.9	-0.5	-1.1	-0.7
Locomotion velocity, hab. session 2	0.6	0.8	1.3	0.3	-0.9	-0.8	-1.2	-1.0
Novel to familiar place preference ratio	1.0	1.0	2.0	-1.4	-1.1	0.9	-0.7	0.8
Novelty place preference	1.0	1.0	2.0	-1.4	-0.7	1.1	-0.3	1.1
Time in novel zone, NPP test	1.2	1.2	2.4	-1.5	-0.8	1.3	-0.3	1.2
Total zone transitions, NPP test	0.3	0.4	0.8	0.9	0.8	-0.3	0.5	-0.4
Total locomotion distance, NPP test	0.5	0.7	1.0	0.3	-0.8	-0.9	-1.0	-0.9
Locomotion velocity, NPP test	0.5	0.8	1.4	0.6	-0.5	-1.2	-0.8	-1.1
Intraocular pressure	0.3	0.5	0.9	-0.0	0.8	0.6	0.9	0.6
Delta distance traveled before/after self-admin	0.6	0.6	1.5	0.9	1.2	-0.0	1.0	-0.1
Delta ambulatory time before/after self-admin	0.7	0.7	1.7	1.0	1.3	-0.1	1.0	-0.2
Parametrial fat weight	0.1	0.1	0.3	0.3	0.5	0.2	0.4	0.1
Pavlov. Cond. lever latency	1.9	2.4	4.4	2.1	1.0	-2.0	0.4	-1.7
Pavlov. Cond. magazine entry latency	1.5	1.9	3.3	-1.8	-1.5	1.5	-1.0	1.0
Pavlov. Cond. change in total contacts	1.4	1.4	2.6	-1.6	-0.8	1.6	-0.4	1.2
Pavlov. Cond. index score	2.3	2.9	5.2	-2.3	-0.9	2.2	-0.2	1.9
Pavlov. Cond. latency score	2.2	2.8	5.0	-2.2	-1.0	2.1	-0.4	1.8
Pavlov. Cond. lever contacts	2.0	2.3	4.2	-1.8	-0.2	2.0	0.4	1.9
Pavlov. Cond. magazine entry number	2.9	3.7	6.6	2.6	1.7	-2.2	1.0	-1.7
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	0.5	0.1	-0.2	-0.1	-0.4
Pavlov. Cond. lever-magazine prob. diff.	1.8	2.3	4.0	-2.0	-0.8	2.0	-0.2	1.7
Pavlov. Cond. response bias	2.2	2.7	4.7	-2.1	-0.8	2.2	-0.1	1.9
Pavlov. Cond. lever latency	0.2	0.3	0.7	0.5	0.8	0.0	0.7	0.0
Pavlov. Cond. magazine entry latency	0.3	0.4	0.9	-0.4	-0.9	-0.2	-0.8	-0.2
Pavlov. Cond. change in total contacts	0.7	0.9	2.1	-1.1	-1.4	0.3	-1.1	0.3
Pavlov. Cond. index score	0.6	0.8	2.0	-0.6	-1.4	-0.3	-1.3	-0.3
Pavlov. Cond. latency score	0.7	0.9	2.0	-0.5	-1.4	-0.4	-1.3	-0.4
Pavlov. Cond. lever contacts	0.4	0.5	1.3	-0.8	-1.1	0.0	-0.9	0.1
Pavlov. Cond. magazine entry number	0.6	0.7	1.6	0.9	1.3	-0.1	1.0	-0.1
Pavlov. Cond. intertrial magazine entries	0.5	0.7	1.6	0.9	1.3	-0.2	1.0	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.4	-0.3	-1.2	-0.4	-1.1	-0.4
Pavlov. Cond. response bias	0.9	1.2	2.9	-0.8	-1.7	-0.3	-1.5	-0.3
Time in closed arm before self-admin	1.6	1.8	3.1	-1.7	-1.8	0.9	-1.3	0.7
Time in closed arm after self-admin	0.3	0.3	0.6	-0.1	-0.8	-0.4	-0.8	-0.4
Time in open arm before self-admin	1.5	1.7	3.2	1.8	1.7	-0.7	1.1	-0.8
Time in open arm after self-admin	1.2	1.4	2.3	-1.5	-1.4	1.0	-1.1	0.7
Bone: periosteal estimation	1.9	3.8	8.3	-0.4	-2.7	-1.1	-2.9	-1.4
Bone: periosteal perimeter	0.7	1.1	2.5	-0.3	-1.5	-0.4	-1.6	-0.7
Bone: post-yield work	1.2	1.7	3.6	-0.3	-1.8	-0.7	-1.9	-0.9
Progressive ratio test 1 active lever presses	0.0	0.0	0.1	0.2	0.0	-0.2	-0.1	-0.2
Progressive ratio test 1 breakpoint	0.1	0.1	0.1	0.3	0.0	-0.4	-0.1	-0.3
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.2	0.3	-0.1	-0.5	-0.2	-0.4
Progressive ratio test 2 active lever presses	0.2	0.3	0.6	-0.6	-0.2	0.8	-0.1	0.5
Progressive ratio test 2 breakpoint	0.3	0.4	0.9	-0.5	0.3	0.9	0.4	0.8
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.3	-0.5	-0.2	0.5	-0.1	0.4
Incentive Sensitization - Responses	0.2	0.2	0.3	-0.5	-0.4	0.6	-0.4	0.3
Incentive Sensitization - Breakpoint	0.1	0.1	0.3	-0.4	-0.3	0.5	-0.2	0.3
Sum of active levers in priming session hrs 5-6	1.0	1.0	1.4	-1.1	-1.2	1.0	-1.0	0.4
Progressive ratio	0.3	0.3	0.7	0.8	0.2	-0.5	-0.2	-0.8
Food seeking constrained by brief footshock	0.7	0.8	1.6	0.9	-0.4	-1.0	-0.8	-1.3
Seeking ratio, punishment vs. effort	0.1	0.2	0.3	0.0	-0.5	-0.5	-0.5	-0.4
Retroperitoneal fat weight	0.3	1.1	2.1	1.2	-0.2	-1.3	-0.7	-1.4
Reaction time number correct	0.8	1.1	2.1	1.4	1.2	-0.9	0.8	-0.8
Reaction time mean minus median	1.4	1.9	3.3	-1.8	-1.7	0.9	-1.2	0.8
Reaction time mean minus median AUC	1.0	1.3	2.5	-1.6	-1.3	1.0	-0.9	0.8
Reaction time num false alarms	2.9	3.9	7.9	2.8	1.7	-2.1	0.9	-2.0
Reaction time num false alarms AUC	3.3	4.6	8.8	3.0	1.6	-2.5	0.7	-2.2
Reaction time trials correct on left	0.8	1.1	2.1	1.4	1.2	-0.9	0.8	-0.8
Reaction time trials on left	0.7	1.1	2.0	1.4	1.2	-0.9	0.8	-0.8
Reaction time mean	3.7	5.1	8.1	-2.9	-2.7	2.0	-2.1	1.3
Reaction time mean AUC	3.3	4.5	7.3	-2.7	-2.4	2.0	-1.8	1.4
Median of all reaction times	3.5	4.8	7.5	-2.7	-2.5	2.2	-1.9	1.4
Reaction time omissions	0.9	1.2	2.6	-1.2	-0.0	1.6	0.3	1.3
Reaction time false alarm rate	1.3	1.9	3.6	1.9	0.9	-1.6	0.3	-1.5
Reaction time premature initiation rate	0.0	0.0	0.0	-0.2	-0.0	0.2	0.0	0.2
Reaction time premature initiations	0.1	0.2	0.4	0.6	0.6	-0.2	0.5	-0.2
Std. dev. reaction times	3.4	4.8	8.0	-2.8	-2.8	1.6	-2.0	1.2
Reaction time trials completed	0.7	1.1	2.0	1.4	1.2	-0.9	0.8	-0.8
Reaction time trials AUC	0.7	1.0	1.8	1.3	1.2	-0.8	0.9	-0.7
Run reversals in cocaine runway, females	1.1	1.1	2.0	1.1	-0.2	-1.3	-0.7	-1.4
Run reversals in cocaine runway, males	1.1	1.0	2.0	1.4	0.4	-1.2	-0.0	-1.3
Latency to leave start box in cocaine runway	3.3	3.5	5.4	2.3	2.3	-1.6	1.8	-1.0
Latency to leave start box in cocaine runway, F	1.7	1.9	3.6	1.3	1.9	-0.9	1.8	-0.2
Latency to leave start box in cocaine runway, M	2.6	2.4	4.8	2.2	0.8	-1.8	0.1	-1.9
Std. dev. time between licks in bursts	2.9	3.4	5.9	2.3	2.4	-1.3	1.9	-0.9
Total sessions with >9 infusions	1.9	2.1	4.1	1.6	-0.1	-2.0	-0.7	-1.9
Short access day 1 total inactive lever presses	0.6	0.6	1.4	0.8	-0.1	-1.2	-0.4	-1.0
Short access day 10 total inactive lever presses	0.2	0.2	0.5	-0.3	-0.7	0.0	-0.7	-0.1
Short access day 1 total infusions	0.6	0.6	1.3	0.4	-0.6	-1.1	-0.7	-0.9
Short access day 10 total infusions	1.5	1.6	3.1	-1.0	0.6	1.8	1.0	1.6
Short access total infusions	0.0	0.0	0.0	0.2	0.2	-0.1	0.1	-0.1
Short access day 1 locomotion	0.8	0.9	1.9	0.8	-0.3	-1.4	-0.6	-1.2
Short access day 10 total locomotion	0.3	0.4	0.7	0.2	-0.7	-0.6	-0.8	-0.7
Short access total locomotion	1.8	1.9	3.7	1.4	-0.3	-1.9	-0.8	-1.8
One hour access (0.3 mA shock)	0.9	1.0	2.2	-1.1	0.0	1.5	0.4	1.2
Compulsive drug intake	0.2	0.2	0.3	0.1	0.5	0.4	0.5	0.3
One hour access (shock baseline)	0.6	0.7	1.4	-1.1	-0.2	1.2	0.1	1.0
Social response proportion	0.3	0.3	0.5	-0.7	-0.6	0.7	-0.5	0.3
Social responses	0.1	0.1	0.2	0.4	0.0	-0.3	-0.2	-0.5
Social time	0.9	1.2	2.3	-1.3	-0.2	1.5	0.2	1.3
Soleus weight	1.2	3.4	6.4	2.0	-0.1	-2.5	-0.8	-2.4
Bone: stiffness	3.0	4.7	8.3	0.5	-2.4	-1.9	-2.9	-2.2
Tibialis anterior weight	2.2	7.4	13.8	3.7	2.3	-3.1	1.3	-2.6
Time to tail flick, vehicle, before self-admin	0.4	0.4	0.9	0.4	0.9	0.1	0.9	0.2
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.5	-0.5	-0.2	0.7	-0.1	0.5
Time to tail flick, test, before self-admin	1.2	1.2	2.5	1.6	0.8	-1.1	0.3	-1.2
Time to tail flick, test, after self-admin	1.4	1.5	2.7	1.6	1.0	-1.5	0.6	-1.1
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	1.0	-0.7	-1.0	0.3	-0.9	0.1
Delta time to tail flick, test, before/after SA	0.1	0.1	0.2	-0.3	0.1	-0.0	0.4	0.4
Tibia length	3.1	8.7	19.4	-1.4	-4.4	-1.0	-4.4	-1.5
Ambulatory time before self-admin	2.6	2.7	6.4	-1.2	-2.5	-0.2	-2.3	-0.4
Ambulatory time after self-admin	0.3	0.4	0.5	0.3	-0.6	-0.6	-0.7	-0.7
Bone: tissue strength	0.1	0.1	0.3	0.2	-0.2	-0.5	-0.3	-0.4
Total heroin consumption	0.7	0.9	1.7	-1.3	-0.5	1.1	-0.1	1.1
Bone: trabecular number	0.7	1.1	1.9	-1.4	-1.4	0.6	-1.0	0.6
Bone: trabecular spacing	0.5	0.7	1.4	1.2	0.3	-0.9	-0.2	-1.1
Bone: trabecular thickness	3.0	3.6	7.3	-2.7	-1.5	2.0	-0.7	2.0
Bone: trabecular tissue density	0.2	0.3	0.7	0.2	-0.6	-0.3	-0.8	-0.6
Water consumed over 24 hours	0.5	0.6	1.3	0.5	1.1	0.0	1.1	0.2
Number of responses in last shaping day	0.1	0.1	0.1	0.4	0.3	-0.2	0.2	-0.2