Mstn

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	LHb	gene expression	Mstn	0.25	0.15	4.3e-03	0.01	0.01	0	0.01	2.3e-01	1.4e-01	3.2e-01	1.7e-01
2	Brain	gene expression	Mstn	0.15	0.08	1.3e-11	0.11	0.12	0.1	0.11	1.3e-10	5.6e-11	5.9e-10	2.8e-10
3	OFC	gene expression	Mstn	0.35	0.15	1.5e-04	0.14	0.14	0.15	0.15	3.2e-04	3.5e-04	2.3e-04	2.6e-04
4	Adipose	gene expression	Mstn	0.18	0.08	0.0e+00	0.11	0.15	0.15	0.15	8.8e-12	1.5e-16	1.5e-16	2.4e-16
5	IC	gene expression	Mstn	0.1	0.07	4.6e-03	0.02	0.04	0	0.02	5.5e-02	7.9e-03	2.2e-01	4.4e-02
6	PL	gene expression	Mstn	0.08	0.05	2.2e-06	0.03	0.04	0.04	0.04	1.2e-04	1.2e-05	7.7e-05	6.1e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	1.5	2.6	5.7	-2.4	-1.6	2.1	-0.8	-0.3	1.4
Area under the delay curve	0.0	0.0	0.1	0.0	0.1	0.2	0.1	0.0	0.1
BMI with tail	2.7	9.2	18.4	3.4	4.3	-1.9	3.6	3.0	-0.2
BMI without tail	1.1	3.4	6.4	0.7	2.4	0.6	2.5	2.4	1.4
Body weight	0.0	0.1	0.2	0.1	-0.2	-0.3	-0.3	-0.4	-0.3
Weight adjusted by age	1.4	2.1	3.7	0.0	-1.5	-0.9	-1.9	-1.9	-1.5
Bone surface	0.5	0.9	1.7	-0.5	-1.3	-0.1	-1.3	-1.2	-0.6
Bone volume	1.1	1.9	3.9	-1.7	-2.0	1.0	-1.5	-1.2	0.2
Breakpoint value in progressive ratio session	0.6	0.7	1.5	-1.2	-0.7	1.2	-0.3	-0.0	1.0
Number of licking bursts	1.1	1.8	2.8	-0.6	1.0	1.4	1.4	1.6	1.7
Context. condit. distance diff. score	2.9	3.4	5.7	0.1	2.0	1.4	2.4	2.4	1.8
Locomotion velocity, session 1	0.1	0.1	0.1	0.0	0.3	0.2	0.4	0.4	0.3
Locomotion distance, session 1	0.2	0.3	0.7	0.8	0.4	-0.7	0.1	-0.1	-0.6
Locomotion velocity, session 2	1.2	1.4	2.9	1.7	1.0	-1.6	0.4	0.1	-1.2
Locomotion distance, session 2	0.8	1.2	2.5	1.5	0.5	-1.6	-0.1	-0.4	-1.4
Locomotion velocity, session 3	0.1	0.1	0.3	0.4	0.5	-0.1	0.5	0.4	0.1
Locomotion distance, session 3	0.6	0.6	1.2	-0.0	0.8	0.5	1.0	1.1	0.8
Stereotopy head waving bouts, day 3	0.3	0.3	0.8	0.9	0.7	-0.6	0.4	0.2	-0.5
Stereotopy head waving duration, day 3	0.0	0.0	0.0	0.2	0.2	0.0	0.1	0.1	-0.1
Locomotion velocity, session 7	1.6	1.8	3.2	1.2	-0.4	-1.8	-1.0	-1.3	-1.8
Locomotion distance, session 7	1.0	1.3	2.6	1.1	-0.2	-1.6	-0.7	-1.0	-1.5
Stereotopy head waving bouts, day 7	0.2	0.3	0.6	-0.7	-0.2	0.8	0.0	0.2	0.7
Stereotopy head waving duration, day 7	0.4	0.4	0.9	-0.9	-0.7	0.8	-0.4	-0.2	0.5
Locomotion velocity, session 8	0.4	0.5	0.9	0.1	0.8	0.5	0.9	1.0	0.6
Locomotion distance, session 8	1.1	1.6	3.3	1.0	1.8	-0.0	1.7	1.5	0.5
Degree of sensitization distance	2.1	2.1	3.3	0.7	-1.1	-1.5	-1.6	-1.8	-1.8
Degree of sensitization stereotypy	0.4	0.4	1.0	-0.8	-0.2	1.0	0.2	0.4	0.9
Conditioned locomotion	0.0	0.0	0.1	0.2	-0.0	-0.2	-0.2	-0.2	-0.2
Cocaine response after cond. corrected	1.2	1.4	2.7	1.0	-0.4	-1.4	-1.0	-1.3	-1.6
Cocaine response after cond. not corrected	2.7	3.2	5.4	0.6	-1.5	-1.5	-2.1	-2.3	-2.1
Cocaine response before conditioning	1.0	1.2	2.2	-0.5	-1.4	-0.3	-1.5	-1.4	-0.7
Saline control response	0.3	0.4	0.7	-0.4	0.4	0.6	0.7	0.8	0.8
Bone: connectivity density	0.2	0.3	0.7	-0.8	-0.5	0.8	-0.2	-0.0	0.5
Bone: cortical apparent density	3.6	4.9	9.8	3.1	2.7	-2.4	1.8	1.2	-1.3
Bone: cortical area	0.7	1.0	1.9	1.0	-0.2	-1.3	-0.7	-0.9	-1.4
Bone: cortical porosity	1.1	1.2	2.9	-1.7	-0.9	1.5	-0.3	0.1	1.2
Bone: cortical porosity	1.4	1.6	3.3	-1.8	-1.6	1.2	-1.0	-0.6	0.7
Bone: cortical thickness	0.9	1.6	3.3	1.8	1.6	-1.2	1.1	0.7	-0.7
Bone: cortical thickness	0.3	0.3	0.6	0.5	-0.2	-0.7	-0.5	-0.6	-0.8
Bone: cortical tissue density	3.4	4.6	9.4	3.1	2.6	-2.4	1.7	1.1	-1.3
Condit. Reinf. active minus inactive responses	2.2	2.5	4.4	-2.1	-2.1	1.4	-1.6	-1.2	0.8
Condit. Reinf. active-inactive response ratio	1.2	1.3	2.5	-1.6	-1.5	1.0	-1.1	-0.8	0.6
Condit. Reinf. active responses	1.9	2.4	4.8	-1.6	-2.2	0.7	-1.9	-1.6	0.1
Condit. Reinf. inactive responses	0.4	0.4	0.7	0.4	-0.5	-0.6	-0.7	-0.9	-0.8
Incentive salience index mean	1.8	2.2	4.7	-2.2	-1.8	1.6	-1.1	-0.7	1.1
Condit. Reinf. lever presses	0.8	1.1	2.5	-1.4	-0.4	1.6	0.1	0.4	1.4
Condit. Reinf. active minus inactive responses	1.9	2.5	5.0	-1.6	-2.2	0.7	-2.0	-1.7	-0.0
Condit. Reinf. active-inactive response ratio	1.6	1.8	3.5	-1.9	-1.7	1.3	-1.2	-0.8	0.7
Condit. Reinf. active responses	0.8	1.0	2.0	-0.5	-1.4	-0.1	-1.4	-1.4	-0.6
Condit. Reinf. inactive responses	0.6	0.8	1.4	0.8	-0.3	-1.1	-0.7	-0.9	-1.2
Condit. Reinf. lever presses	0.1	0.1	0.2	-0.3	-0.5	-0.0	-0.4	-0.3	-0.1
Condit. Reinf. lever reinforcers received	0.9	1.2	2.3	-0.3	-1.3	-0.4	-1.5	-1.5	-0.8
Conditioned reinforcement - actives	0.1	0.1	0.2	0.4	0.4	-0.4	0.3	0.2	-0.2
Conditioned reinforcement - inactives	0.1	0.2	0.3	0.2	-0.3	-0.4	-0.5	-0.6	-0.5
Conditioned locomotion	1.6	2.1	4.1	1.9	0.6	-2.0	-0.2	-0.6	-1.9
Patch foraging indifference point 0 sec	1.3	2.4	4.3	1.7	2.1	-1.3	1.8	1.5	-0.3
Patch foraging indifference point AUC	0.4	0.6	1.2	0.4	-0.4	-1.1	-0.7	-0.8	-1.0
Delay disc. indifference point, 0s delay	0.0	0.0	0.0	-0.1	-0.0	0.1	0.1	0.1	0.1
Delay disc. indifference point, 16s delay	0.2	0.3	0.6	-0.7	-0.5	0.7	-0.3	-0.2	0.5
Delay disc. indifference point, 2s delay	0.0	0.0	0.0	0.0	-0.2	-0.1	-0.2	-0.2	-0.2
Delay disc. indifference point, 24s delay	0.4	0.5	0.6	-0.1	0.6	0.8	0.8	0.8	0.8
Delay disc. indifference point, 4s delay	0.2	0.2	0.4	0.6	0.6	-0.2	0.4	0.3	-0.2
Delay disc. indifference point, 8s delay	0.2	0.2	0.4	-0.3	-0.6	0.3	-0.6	-0.6	-0.1
Indifference point function ln k	1.0	1.7	2.8	0.1	1.5	0.9	1.7	1.7	1.2
Indifference point function log k	1.0	1.7	2.8	0.1	1.5	0.9	1.7	1.7	1.2
Patch foraging total patch changes 0 sec	1.2	2.3	4.1	1.7	2.0	-1.3	1.8	1.5	-0.3
Patch foraging total patch changes 12 sec	0.3	0.3	1.1	0.6	0.1	-1.0	-0.0	-0.1	-0.7
Patch foraging total patch changes 18 sec	0.5	0.8	1.1	1.0	1.1	-0.9	0.9	0.8	-0.4
Patch foraging total patch changes 24 sec	0.2	0.3	0.7	0.7	0.5	-0.8	0.4	0.3	-0.5
Patch foraging total patch changes 6 sec	1.3	1.9	3.1	1.7	1.7	-1.4	1.4	1.1	-0.6
Patch foraging time to switch 0 sec	0.3	0.5	1.0	-1.0	-0.8	1.0	-0.5	-0.3	0.6
Patch foraging water rate 0 sec	0.2	0.5	1.1	1.0	0.9	-0.7	0.6	0.4	-0.5
Patch foraging water rate 12 sec	0.3	0.6	1.0	0.2	0.9	0.4	1.0	1.0	0.6
Patch foraging water rate 18 sec	0.5	0.7	1.2	-0.3	0.6	1.0	0.9	1.0	1.1
Patch foraging water rate 24 sec	0.0	0.1	0.1	0.3	-0.1	-0.1	-0.2	-0.3	-0.3
Patch foraging water rate 6 sec	1.1	1.5	2.7	0.5	1.6	0.6	1.6	1.6	0.9
Seeking ratio, delayed vs. immediate footshock	1.5	1.8	3.7	-1.3	-1.9	0.6	-1.7	-1.4	-0.2
Distance traveled before self-admin	2.5	3.3	6.6	-2.0	-2.6	1.2	-2.1	-1.7	0.1
Distance traveled after self-admin	0.8	1.0	2.1	-1.1	-1.4	0.4	-1.2	-1.0	0.0
Extensor digitorum longus weight	4.3	16.9	36.8	6.1	2.9	-5.7	0.7	-0.7	-4.8
Bone: elastic displacement	1.4	1.7	3.3	-1.3	0.3	1.7	0.9	1.2	1.8
Bone: elastic work	0.8	1.1	2.0	-1.3	-1.4	0.8	-1.1	-0.8	0.4
Bone: endosteal estimation	2.6	5.7	10.9	-1.5	-3.3	-0.1	-3.2	-3.0	-1.2
Bone: endosteal perimeter	1.0	2.0	3.8	-0.7	-1.9	-0.2	-1.9	-1.9	-0.8
Epididymis fat weight	1.0	3.4	6.1	0.4	-1.7	-1.5	-2.3	-2.5	-2.0
Delta time in closed arm before/after self-admin	0.3	0.2	0.5	0.7	0.6	-0.7	0.3	0.2	-0.3
Delta time in open arm before/after self-admin	2.3	2.3	4.2	-2.0	-2.1	1.3	-1.5	-1.1	0.5
Diff in mean of infusions in LGA sessions	0.4	0.5	1.2	-1.1	-0.8	0.8	-0.5	-0.3	0.6
Delay discount exponential model param	0.0	0.0	0.1	-0.0	-0.2	-0.3	-0.2	-0.2	-0.2
Extinction: sum of active levers before priming	0.5	0.5	1.1	-1.1	-0.7	0.9	-0.4	-0.2	0.7
Active lever presses in extinction session 6	0.6	0.6	1.2	-1.1	-0.7	1.0	-0.4	-0.1	0.7
Bone: final force	1.4	2.3	4.1	0.2	-1.5	-1.0	-1.9	-2.0	-1.7
Bone: final moment	1.0	1.6	2.7	0.4	-1.1	-1.0	-1.5	-1.6	-1.5
Food consumed during 24 hour testing period	0.8	1.1	1.9	-0.2	-1.2	-0.5	-1.4	-1.4	-1.0
Glucose	1.3	2.1	3.5	-0.5	1.2	1.2	1.7	1.9	1.7
Heart weight	0.2	0.3	0.5	-0.3	-0.7	0.1	-0.7	-0.6	-0.2
Delay discount hyperbolic model param	0.0	0.0	0.1	-0.1	-0.2	-0.3	-0.2	-0.2	-0.1
Intermittent access intake day 1-15 change	0.2	0.4	0.7	0.7	0.9	-0.7	0.7	0.5	0.0
Intermittent access intake escalation	0.4	0.8	1.6	0.8	1.2	-0.5	1.1	0.9	0.2
Intermittent access intake escalation 2	0.4	0.5	0.8	-0.0	0.8	0.2	0.9	0.9	0.8
Intermitt. access day 1 inactive lever presses	0.8	2.9	5.4	1.1	2.3	-0.4	2.3	2.1	0.8
Intermitt. access day 15 inactive lever presses	0.1	0.3	0.6	0.5	0.7	-0.1	0.6	0.6	0.1
Intermitt. access escalation Index	0.4	0.5	0.8	0.2	0.9	0.5	0.9	0.9	0.7
Intermittent access day 1 total infusions	0.3	0.4	0.9	-0.7	0.1	0.9	0.4	0.6	1.0
Intermittent access day 15 total infusions	1.0	1.5	2.9	0.6	1.7	-0.0	1.7	1.6	0.9
Intermittent access terminal intake (last 3 days)	1.4	1.8	3.4	0.8	1.8	-0.2	1.8	1.7	0.8
Intermittent access total infusions	0.5	0.5	0.9	0.0	0.8	0.4	1.0	1.0	0.8
Intermittent access day 1 locomotion	0.0	0.0	0.0	0.1	0.1	0.2	0.1	0.1	0.0
Intermittent access day 15 total locomotion	0.3	0.5	1.1	1.1	0.4	-1.0	-0.0	-0.3	-1.0
Intermittent access total locomotion	0.4	0.5	1.1	0.8	1.0	-0.2	0.9	0.7	-0.0
Intermittent access standard deviation	0.1	0.2	0.6	0.7	0.5	-0.7	0.3	0.2	-0.3
Left kidney weight	0.0	0.1	0.2	-0.4	-0.3	0.4	-0.1	-0.1	0.3
Right kidney weight	0.1	0.5	1.1	0.9	0.2	-1.0	-0.2	-0.5	-1.0
Cocaine induced anxiety	0.7	1.0	2.1	1.4	1.3	-0.8	0.9	0.6	-0.5
Post-drug Anxiety	1.0	1.1	2.6	1.6	1.0	-1.2	0.5	0.1	-1.0
Baseline Anxiety	0.7	0.8	1.6	-0.9	-1.3	0.3	-1.1	-0.9	-0.0
Tail length	2.0	7.7	13.7	-3.5	-3.7	2.4	-2.9	-2.3	1.0
Length with tail	2.9	12.4	25.0	-3.3	-5.0	1.4	-4.5	-4.0	-0.4
Length without tail	2.1	6.8	12.7	-1.0	-3.3	-0.9	-3.6	-3.5	-1.8
Times rat made contact with spout	1.9	2.1	3.7	-1.0	0.7	1.7	1.4	1.7	1.9
Lifetime Intake	0.4	0.4	0.9	0.5	0.9	-0.1	0.9	0.8	0.3
Liver weight, left	1.0	1.6	2.9	-0.4	-1.6	-0.4	-1.7	-1.7	-1.0
Liver weight, right	0.4	0.7	1.2	-0.5	-1.1	-0.0	-1.1	-1.0	-0.4
Locomotor activity	0.0	0.0	0.0	0.2	0.1	-0.2	0.0	-0.0	-0.1
Locomotor testing distance	0.2	0.4	0.8	-0.7	0.0	0.8	0.4	0.6	0.9
Locomotor testing rearing	0.7	1.4	2.4	-0.2	1.2	0.8	1.5	1.5	1.3
Locomotion in novel chamber	2.0	2.5	5.2	1.9	0.1	-2.3	-0.6	-1.1	-2.2
Locomotion in novel chamber post-restriction	1.3	2.1	4.4	1.9	0.4	-1.8	-0.4	-0.9	-2.1
Fecal boli incidents, locomotor time 1	0.1	0.1	0.3	-0.4	0.0	0.3	0.3	0.3	0.5
Change in fecal boli incidents, locomotor task	0.2	0.2	0.3	0.2	0.6	0.4	0.6	0.6	0.4
Time >=10cm from walls, locomotor time 1	0.9	0.9	1.8	0.9	-0.3	-1.1	-0.8	-1.1	-1.4
Bouts of movement, locomotor time 1	0.7	0.7	1.4	1.0	1.2	-0.7	1.0	0.8	-0.2
Total resting periods, locomotor time 1	1.0	1.1	1.9	1.4	1.3	-1.1	0.9	0.7	-0.5
Rest time, locomotor task time 1	0.6	0.7	1.3	0.2	1.0	0.2	1.1	1.1	0.7
Distance moved, locomotor task time 1	0.1	0.1	0.5	-0.3	-0.3	0.7	-0.3	-0.2	0.2
Vertical activity count, locomotor time 1	0.0	0.0	0.1	0.1	-0.1	0.2	-0.2	-0.2	-0.2
Time >=10cm from walls, locomotor time 2	0.6	0.9	1.9	-1.4	-0.9	1.3	-0.4	-0.1	0.9
Bouts of movement, locomotor time 2	1.4	2.2	4.5	2.1	2.0	-1.1	1.4	1.0	-0.7
Total resting periods, locomotor time 2	1.2	2.1	4.0	2.0	2.0	-1.1	1.5	1.0	-0.6
Rest time, locomotor task time 2	0.8	1.0	2.0	0.4	1.3	-0.2	1.4	1.4	0.5
Distance moved, locomotor task time 2	0.3	0.4	0.8	-0.4	-0.8	0.3	-0.9	-0.8	-0.2
Vertical activity count, locomotor time 2	0.0	0.1	0.1	0.2	0.3	0.2	0.3	0.3	0.2
Light reinforcement 1	1.8	4.5	9.6	3.1	2.1	-2.8	1.1	0.5	-1.9
Light reinforcement 2	0.3	0.5	1.1	1.0	0.7	-0.9	0.4	0.2	-0.7
Bone: marrow area	2.5	5.4	10.1	-1.4	-3.2	-0.1	-3.1	-3.0	-1.3
Bone: maximum diameter	0.1	0.2	0.4	0.5	0.0	-0.6	-0.2	-0.4	-0.6
Bone: maximum force	2.4	4.3	7.6	-0.2	-2.3	-1.1	-2.7	-2.8	-2.0
Bone: maximum moment	1.7	2.9	5.2	0.0	-1.8	-1.0	-2.2	-2.3	-1.8
Mean time between licks in bursts	0.7	1.8	3.8	1.9	0.9	-1.9	0.3	-0.2	-1.6
Mean num. licks in bursts	0.1	0.2	0.3	0.2	-0.3	-0.5	-0.4	-0.4	-0.5
Cd content in liver	1.3	1.4	2.9	-1.7	-1.0	1.7	-0.5	-0.1	1.3
Co content in liver	1.3	1.5	3.1	-1.2	0.2	1.7	0.7	1.0	1.7
Cu content in liver	0.9	1.1	2.2	-1.5	-0.8	1.4	-0.3	0.1	1.2
Fe content in liver	2.2	2.6	5.5	-2.2	-0.7	2.4	0.2	0.7	2.1
K content in liver	0.9	0.8	2.2	1.2	0.5	-1.5	0.1	-0.1	-1.1
Mg content in liver	0.1	0.1	0.2	0.3	0.4	-0.4	0.4	0.3	-0.1
Mn content in liver	0.5	0.6	1.1	0.3	1.0	0.3	1.1	1.0	0.5
Na content in liver	0.1	0.1	0.2	-0.4	-0.2	0.2	-0.0	0.1	0.2
Rb content in liver	2.6	3.1	6.5	2.4	0.9	-2.5	-0.1	-0.7	-2.2
Se content in liver	0.1	0.1	0.2	0.4	0.3	-0.4	0.2	0.1	-0.3
Sr content in liver	0.2	0.2	0.3	0.3	0.6	-0.2	0.6	0.5	0.2
Zn content in liver	0.0	0.0	0.0	0.1	0.1	-0.1	0.1	0.1	-0.0
Bone: minimum diameter	1.1	2.0	3.4	0.3	-1.4	-1.1	-1.7	-1.9	-1.6
Time in familiar zone, hab. session 1	0.7	0.6	1.1	0.2	1.0	0.4	1.0	1.0	0.7
Time in novel zone, hab. session 1	2.0	2.0	4.3	-2.1	-1.7	1.5	-1.1	-0.7	1.0
Total zone transitions, hab. session 1	1.0	1.5	2.3	0.5	-0.9	-1.2	-1.3	-1.5	-1.5
Total locomotion distance, hab. session 1	2.9	4.0	6.9	0.3	-1.9	-1.5	-2.5	-2.6	-2.2
Locomotion velocity, hab. session 1	2.5	3.5	6.0	1.0	-1.2	-1.9	-1.9	-2.2	-2.4
Time in familiar zone, hab. session 2	0.2	0.2	0.3	-0.3	0.2	0.4	0.4	0.5	0.6
Time in novel zone, hab. session 2	0.1	0.1	0.2	-0.2	0.2	0.3	0.4	0.4	0.5
Total zone transitions, hab. session 2	0.0	0.1	0.1	0.0	0.3	0.1	0.3	0.3	0.2
Total locomotion distance, hab. session 2	0.6	0.7	1.4	0.1	-0.9	-0.5	-1.1	-1.2	-0.9
Locomotion velocity, hab. session 2	0.7	1.0	1.7	0.3	-0.8	-0.8	-1.2	-1.3	-1.1
Novel to familiar place preference ratio	0.8	0.9	1.9	-1.4	-1.1	1.0	-0.7	-0.5	0.6
Novelty place preference	0.7	0.8	1.8	-1.3	-0.8	1.1	-0.3	-0.0	0.9
Time in novel zone, NPP test	0.9	0.9	2.2	-1.5	-0.8	1.3	-0.3	0.0	1.1
Total zone transitions, NPP test	0.3	0.4	1.0	1.0	0.7	-0.8	0.3	0.1	-0.5
Total locomotion distance, NPP test	0.5	0.7	1.2	0.2	-0.8	-0.7	-1.0	-1.1	-1.0
Locomotion velocity, NPP test	0.5	0.7	1.4	0.6	-0.4	-1.0	-0.8	-0.9	-1.2
Intraocular pressure	0.3	0.4	0.7	0.3	0.9	0.1	0.9	0.8	0.4
Delta distance traveled before/after self-admin	0.4	0.4	0.7	0.8	0.8	-0.6	0.6	0.5	-0.1
Delta ambulatory time before/after self-admin	0.4	0.5	1.0	1.0	0.9	-0.9	0.6	0.4	-0.3
Parametrial fat weight	0.4	1.0	2.1	0.8	1.4	0.1	1.3	1.2	0.3
Pavlov. Cond. lever latency	1.7	2.2	4.6	2.1	0.9	-2.1	0.1	-0.3	-1.8
Pavlov. Cond. magazine entry latency	1.7	2.2	4.8	-2.2	-1.8	1.6	-1.1	-0.7	1.1
Pavlov. Cond. change in total contacts	1.2	1.2	2.7	-1.6	-1.1	1.4	-0.5	-0.2	1.1
Pavlov. Cond. index score	2.0	2.5	5.5	-2.4	-1.1	2.2	-0.3	0.2	1.9
Pavlov. Cond. latency score	2.0	2.5	5.6	-2.4	-1.3	2.1	-0.4	0.1	1.8
Pavlov. Cond. lever contacts	1.7	2.1	4.3	-2.0	-0.7	2.1	0.1	0.5	1.8
Pavlov. Cond. magazine entry number	2.4	3.0	6.6	2.6	1.8	-2.1	1.0	0.5	-1.6
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	0.5	0.1	-0.4	-0.1	-0.2	-0.4
Pavlov. Cond. lever-magazine prob. diff.	1.7	2.1	4.7	-2.2	-1.1	2.0	-0.4	0.1	1.6
Pavlov. Cond. response bias	2.1	2.6	5.8	-2.4	-1.3	2.2	-0.5	-0.0	1.8
Pavlov. Cond. lever latency	0.2	0.3	0.7	0.6	0.8	-0.1	0.7	0.6	0.1
Pavlov. Cond. magazine entry latency	0.3	0.3	0.7	-0.7	-0.8	0.3	-0.7	-0.5	0.0
Pavlov. Cond. change in total contacts	0.6	0.9	1.8	-1.2	-1.4	0.5	-1.0	-0.8	0.2
Pavlov. Cond. index score	0.5	0.7	1.6	-0.8	-1.3	0.1	-1.1	-1.0	-0.2
Pavlov. Cond. latency score	0.6	0.8	1.7	-0.6	-1.3	-0.1	-1.2	-1.1	-0.4
Pavlov. Cond. lever contacts	0.4	0.5	1.0	-1.0	-1.0	0.5	-0.7	-0.5	0.2
Pavlov. Cond. magazine entry number	0.4	0.5	1.0	1.0	1.0	-0.5	0.7	0.5	-0.2
Pavlov. Cond. intertrial magazine entries	0.5	0.7	1.4	1.0	1.2	-0.4	1.0	0.8	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.1	-0.6	-1.0	-0.1	-0.9	-0.8	-0.3
Pavlov. Cond. response bias	0.8	1.1	2.3	-1.2	-1.5	0.4	-1.3	-1.0	-0.0
Time in closed arm before self-admin	1.3	1.6	2.9	-1.7	-1.7	1.1	-1.3	-0.9	0.5
Time in closed arm after self-admin	0.2	0.3	0.5	-0.4	-0.7	-0.0	-0.7	-0.6	-0.1
Time in open arm before self-admin	1.5	1.6	3.5	1.9	1.6	-1.4	1.0	0.6	-0.7
Time in open arm after self-admin	1.7	1.8	3.7	-1.4	-1.9	0.8	-1.6	-1.4	-0.0
Bone: periosteal estimation	1.6	3.4	6.3	-0.6	-2.3	-0.6	-2.5	-2.5	-1.5
Bone: periosteal perimeter	0.4	0.7	1.3	-0.4	-1.1	-0.1	-1.1	-1.1	-0.5
Bone: post-yield work	1.1	1.6	3.0	-0.4	-1.6	-0.3	-1.7	-1.7	-1.0
Progressive ratio test 1 active lever presses	0.5	0.7	1.3	0.8	1.1	-0.5	1.0	0.8	0.1
Progressive ratio test 1 breakpoint	0.3	0.4	0.7	0.6	0.9	-0.5	0.7	0.6	0.1
Progressive ratio test 1 inactive lever presses	1.1	1.5	2.7	1.5	1.7	-1.2	1.3	0.9	-0.3
Progressive ratio test 2 active lever presses	0.2	0.3	0.6	0.5	0.8	-0.3	0.6	0.5	0.1
Progressive ratio test 2 breakpoint	0.4	0.5	0.9	0.6	1.0	-0.2	0.9	0.8	0.3
Progressive ratio test 2 inactive lever presses	0.2	0.3	0.7	0.6	0.8	-0.4	0.7	0.6	0.1
Incentive Sensitization - Responses	0.0	0.1	0.1	-0.2	-0.0	0.4	0.0	0.1	0.3
Incentive Sensitization - Breakpoint	0.0	0.1	0.1	-0.1	0.2	0.3	0.2	0.2	0.3
Sum of active levers in priming session hrs 5-6	1.7	1.5	2.8	-1.5	-1.7	0.9	-1.4	-1.1	0.4
Progressive ratio	0.6	1.0	1.8	1.3	0.1	-1.3	-0.4	-0.8	-1.4
Food seeking constrained by brief footshock	0.9	1.1	2.0	0.8	-0.4	-1.4	-0.9	-1.1	-1.3
Seeking ratio, punishment vs. effort	0.1	0.2	0.3	-0.2	-0.5	-0.4	-0.5	-0.5	-0.3
Retroperitoneal fat weight	0.3	1.1	2.3	1.5	0.5	-1.4	-0.1	-0.4	-1.3
Reaction time number correct	0.5	1.0	2.1	1.5	1.2	-1.0	0.8	0.5	-0.7
Reaction time mean minus median	0.8	2.0	4.1	-2.0	-1.8	1.5	-1.2	-0.8	0.8
Reaction time mean minus median AUC	0.6	1.6	3.3	-1.8	-1.4	1.6	-0.8	-0.4	0.9
Reaction time num false alarms	2.3	3.2	7.3	2.7	1.9	-2.1	1.1	0.5	-1.5
Reaction time num false alarms AUC	2.2	3.4	7.9	2.8	1.8	-2.3	0.9	0.3	-1.8
Reaction time trials correct on left	0.5	1.0	2.1	1.5	1.2	-1.0	0.8	0.5	-0.7
Reaction time trials on left	0.5	0.9	2.0	1.4	1.2	-1.0	0.7	0.5	-0.7
Reaction time mean	3.1	5.0	9.3	-3.0	-2.8	2.3	-2.0	-1.4	1.2
Reaction time mean AUC	2.7	4.3	8.3	-2.9	-2.5	2.3	-1.8	-1.2	1.2
Median of all reaction times	3.2	4.6	8.6	-2.9	-2.6	2.2	-1.9	-1.3	1.2
Reaction time omissions	0.4	0.5	1.1	-0.8	-0.0	1.0	0.3	0.5	1.1
Reaction time false alarm rate	1.0	1.4	3.1	1.8	1.2	-1.5	0.6	0.2	-1.1
Reaction time premature initiation rate	0.0	0.1	0.1	-0.3	0.0	0.1	0.1	0.2	0.4
Reaction time premature initiations	0.1	0.2	0.3	0.4	0.6	-0.3	0.5	0.5	0.0
Std. dev. reaction times	2.6	4.9	9.5	-3.1	-2.8	2.2	-2.0	-1.3	1.2
Reaction time trials completed	0.5	0.9	2.0	1.4	1.2	-1.0	0.7	0.5	-0.7
Reaction time trials AUC	0.5	0.9	1.8	1.4	1.2	-0.9	0.8	0.6	-0.6
Run reversals in cocaine runway, females	1.1	1.0	1.6	0.6	-0.7	-1.1	-1.1	-1.3	-1.3
Run reversals in cocaine runway, males	0.8	0.8	1.6	1.3	0.6	-1.3	0.1	-0.2	-1.0
Latency to leave start box in cocaine runway	2.3	2.6	5.0	2.2	2.1	-1.3	1.5	1.1	-0.9
Latency to leave start box in cocaine runway, F	1.8	2.1	4.1	1.4	2.0	-0.6	1.8	1.6	-0.0
Latency to leave start box in cocaine runway, M	2.0	1.8	4.2	2.0	0.7	-1.7	-0.1	-0.5	-1.8
Std. dev. time between licks in bursts	2.6	3.6	6.4	2.5	2.5	-1.7	1.9	1.4	-0.8
Total sessions with >9 infusions	1.3	1.6	3.4	1.8	0.9	-1.8	0.3	-0.1	-1.4
Short access day 1 total inactive lever presses	1.4	1.9	3.8	1.9	0.4	-1.8	-0.3	-0.7	-1.9
Short access day 10 total inactive lever presses	0.0	0.1	0.1	0.3	0.3	-0.3	0.2	0.1	-0.1
Short access day 1 total infusions	1.2	1.5	3.6	1.4	0.1	-1.9	-0.4	-0.7	-1.7
Short access day 10 total infusions	1.8	2.3	4.4	0.6	2.0	0.2	2.1	2.0	1.2
Short access total infusions	0.3	0.4	0.8	0.7	0.9	-0.5	0.7	0.6	-0.1
Short access day 1 locomotion	1.3	1.6	3.2	1.7	0.4	-1.7	-0.3	-0.7	-1.8
Short access day 10 total locomotion	0.2	0.4	0.9	1.0	0.6	-0.7	0.4	0.1	-0.5
Short access total locomotion	1.3	1.6	3.8	1.9	0.9	-1.6	0.2	-0.2	-1.5
One hour access (0.3 mA shock)	0.2	0.3	0.5	0.1	0.6	0.1	0.7	0.7	0.5
Compulsive drug intake	0.7	0.8	1.7	1.3	0.7	-1.2	0.2	-0.1	-1.0
One hour access (shock baseline)	0.2	0.3	0.6	-0.5	0.2	0.6	0.4	0.5	0.8
Social response proportion	0.2	0.3	0.6	-0.8	-0.7	0.4	-0.5	-0.4	0.3
Social responses	0.1	0.1	0.3	0.4	0.0	-0.5	-0.2	-0.3	-0.5
Social time	0.8	1.1	2.3	-1.4	-0.3	1.5	0.3	0.6	1.4
Soleus weight	0.8	2.3	4.9	1.9	0.3	-2.2	-0.5	-0.9	-2.0
Bone: stiffness	2.8	4.6	8.0	0.3	-2.1	-1.5	-2.7	-2.8	-2.3
Tibialis anterior weight	2.0	6.7	14.8	3.8	2.6	-3.2	1.4	0.6	-2.4
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.6	0.3	0.8	0.1	0.8	0.7	0.3
Time to tail flick, vehicle, after self-admin	0.4	0.6	1.2	-0.7	0.1	1.0	0.5	0.6	1.1
Time to tail flick, test, before self-admin	1.7	1.8	3.8	1.9	0.9	-2.0	0.1	-0.3	-1.5
Time to tail flick, test, after self-admin	1.6	1.7	4.0	1.6	0.4	-2.0	-0.2	-0.6	-1.7
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.7	-0.8	-0.3	0.7	-0.0	0.1	0.7
Delta time to tail flick, test, before/after SA	0.2	0.2	0.5	-0.7	-0.4	0.5	-0.1	0.0	0.4
Tibia length	3.4	9.5	18.1	-2.0	-4.3	-0.0	-4.2	-3.9	-1.5
Ambulatory time before self-admin	1.9	2.9	5.7	-2.1	-2.4	1.2	-1.9	-1.5	0.3
Ambulatory time after self-admin	0.3	0.4	0.7	-0.8	-0.8	0.4	-0.6	-0.4	0.3
Bone: tissue strength	0.0	0.0	0.1	-0.2	-0.3	0.1	-0.2	-0.2	-0.0
Total heroin consumption	1.2	1.4	2.9	-1.6	-0.4	1.7	0.3	0.6	1.6
Bone: trabecular number	0.8	1.3	2.6	-1.6	-1.3	1.4	-0.8	-0.5	0.7
Bone: trabecular spacing	0.7	0.9	2.0	1.1	0.1	-1.4	-0.4	-0.7	-1.2
Bone: trabecular thickness	3.0	3.7	7.9	-2.8	-1.3	2.8	-0.3	0.3	2.2
Bone: trabecular tissue density	0.4	0.5	1.0	0.1	-0.7	-0.6	-0.9	-1.0	-0.7
Water consumed over 24 hours	0.3	0.4	0.8	0.2	0.8	0.2	0.9	0.9	0.5
Number of responses in last shaping day	0.1	0.1	0.1	-0.0	0.3	0.1	0.3	0.3	0.3