Hub : Genes

Mrtfa

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver mRNA stability Mrtfa 0.03 0.02 6.2e-03 0 0.01 0.01 0 1.3e-01 1.5e-02 1.7e-02 8.1e-02
2 IC gene expression Mrtfa 0.25 0.12 8.0e-07 0.17 0.16 0.13 0.16 1.6e-07 2.9e-07 3.2e-06 2.4e-07
3 IL gene expression Mrtfa 0.4 0.16 2.4e-06 0.27 0.18 0.25 0.22 4.0e-07 3.6e-05 1.1e-06 4.0e-06
4 OFC gene expression Mrtfa 0.44 0.16 1.4e-07 0.33 0.17 0.27 0.24 1.5e-08 6.3e-05 5.0e-07 1.6e-06
5 Brain mRNA stability Mrtfa 0.04 0.02 7.6e-04 0.05 0.03 0.03 0.03 2.2e-05 4.8e-04 1.7e-03 5.5e-04
6 BLA gene expression Mrtfa 0.29 0.11 3.4e-12 0.18 0.18 0.15 0.18 5.4e-10 4.5e-10 2.7e-08 1.1e-09
7 PL gene expression Mrtfa 0.16 0.07 5.6e-17 0.15 0.17 0.16 0.16 2.2e-16 1.8e-18 1.2e-17 1.3e-17
8 Brain gene expression Mrtfa 0.14 0.07 2.9e-10 0.08 0.12 0.1 0.12 9.3e-08 3.6e-11 5.9e-10 8.3e-11
9 Adipose gene expression Mrtfa 0.02 0.01 9.5e-03 0.01 0.01 0 0.01 1.1e-02 4.1e-02 7.9e-02 4.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.20.30.7-0.00.50.50.5-0.40.70.70.60.8
Area under the delay curve0.60.81.8-0.40.90.90.9-0.70.81.01.4-0.3
BMI with tail0.20.62.1-1.20.50.60.6-0.30.50.2-0.31.4
BMI without tail0.00.10.30.10.10.20.2-0.20.20.1-0.20.5
Body weight0.41.64.7-2.21.11.21.2-1.01.00.70.41.6
Weight adjusted by age0.40.61.10.4-0.9-1.0-1.00.6-0.6-0.8-0.70.4
Bone surface0.30.61.3-0.20.70.70.7-0.30.91.01.10.8
Bone volume0.20.40.6-0.30.60.60.6-0.30.70.80.80.6
Breakpoint value in progressive ratio session0.30.40.5-0.50.60.60.6-0.50.70.70.60.5
Number of licking bursts0.10.10.40.6-0.3-0.3-0.3-0.1-0.1-0.10.20.2
Context. condit. distance diff. score1.11.33.2-0.8-0.9-0.9-0.90.9-1.2-1.6-1.8-0.9
Locomotion velocity, session 10.50.61.7-0.50.70.70.7-0.50.80.81.3-0.2
Locomotion distance, session 10.30.41.80.70.30.30.3-0.10.30.61.3-1.0
Locomotion velocity, session 20.40.40.5-0.70.70.70.7-0.70.60.60.60.7
Locomotion distance, session 21.72.45.3-0.01.41.41.4-1.81.71.92.30.9
Locomotion velocity, session 31.51.72.20.7-1.4-1.4-1.41.4-1.4-1.5-1.3-1.0
Locomotion distance, session 32.72.94.41.6-1.8-1.8-1.81.7-1.7-1.7-1.1-2.1
Stereotopy head waving bouts, day 31.61.92.2-1.51.41.41.4-1.21.41.31.21.4
Stereotopy head waving duration, day 32.22.74.4-2.11.71.71.7-1.41.51.40.92.1
Locomotion velocity, session 70.10.10.2-0.1-0.3-0.3-0.30.2-0.4-0.5-0.4-0.4
Locomotion distance, session 70.30.40.9-0.50.60.60.6-1.00.50.50.8-0.6
Stereotopy head waving bouts, day 70.50.61.3-0.3-0.7-0.7-0.70.7-0.8-1.0-1.10.1
Stereotopy head waving duration, day 70.81.02.6-0.1-0.9-0.9-0.91.1-1.1-1.3-1.6-0.1
Locomotion velocity, session 81.11.32.6-1.61.01.01.0-1.61.00.80.91.0
Locomotion distance, session 80.30.40.8-0.0-0.6-0.6-0.60.2-0.7-0.8-0.9-0.7
Degree of sensitization distance2.92.94.2-2.01.91.91.9-2.01.61.61.01.3
Degree of sensitization stereotypy0.70.71.5-0.1-0.8-0.8-0.80.9-1.0-1.1-1.2-0.1
Conditioned locomotion0.10.10.4-0.30.00.00.0-0.2-0.2-0.3-0.3-0.6
Cocaine response after cond. corrected0.30.30.5-0.60.70.70.7-0.70.50.50.5-0.1
Cocaine response after cond. not corrected0.10.10.5-0.30.40.40.4-0.70.20.30.2-0.2
Cocaine response before conditioning0.40.50.90.9-0.8-0.8-0.80.3-0.7-0.6-0.8-0.4
Saline control response1.11.42.21.0-1.1-1.1-1.11.2-1.3-1.2-1.2-1.5
Bone: connectivity density0.30.41.0-0.30.50.60.6-0.50.70.70.61.0
Bone: cortical apparent density1.52.12.81.6-1.7-1.7-1.71.4-1.4-1.4-1.2-0.5
Bone: cortical area1.82.83.9-2.01.81.81.8-1.31.71.61.41.5
Bone: cortical porosity0.20.20.3-0.50.50.50.5-0.50.30.3-0.00.3
Bone: cortical porosity1.01.11.8-1.31.21.21.2-1.10.90.90.50.7
Bone: cortical thickness0.91.53.2-1.21.11.11.1-1.11.31.21.01.8
Bone: cortical thickness2.42.84.0-1.51.61.61.6-2.01.71.71.71.8
Bone: cortical tissue density1.42.02.71.6-1.6-1.6-1.61.3-1.3-1.4-1.2-0.4
Condit. Reinf. active minus inactive responses0.10.10.20.10.20.20.2-0.20.30.30.40.2
Condit. Reinf. active-inactive response ratio0.20.20.30.1-0.5-0.5-0.50.5-0.5-0.5-0.5-0.4
Condit. Reinf. active responses0.20.21.21.1-0.4-0.4-0.40.3-0.2-0.0-0.0-0.4
Condit. Reinf. inactive responses0.50.63.01.7-0.7-0.7-0.70.5-0.6-0.3-0.3-0.7
Incentive salience index mean0.10.10.20.30.10.10.1-0.10.30.40.40.3
Condit. Reinf. lever presses0.10.10.40.60.00.00.00.00.20.30.30.3
Condit. Reinf. active minus inactive responses1.31.73.1-1.01.31.31.3-1.01.41.41.71.3
Condit. Reinf. active-inactive response ratio2.22.53.6-1.31.51.51.5-1.51.71.61.71.9
Condit. Reinf. active responses0.91.32.0-1.21.11.11.1-0.71.21.11.41.2
Condit. Reinf. inactive responses0.20.20.6-0.80.40.40.4-0.10.40.30.60.3
Condit. Reinf. lever presses0.20.20.40.10.50.50.5-0.30.50.50.60.7
Condit. Reinf. lever reinforcers received0.91.21.9-1.01.11.11.1-0.81.21.21.41.2
Conditioned reinforcement - actives0.30.51.1-0.90.60.60.6-1.00.60.50.70.7
Conditioned reinforcement - inactives1.72.53.6-0.91.71.61.6-1.31.81.91.91.2
Conditioned locomotion2.33.03.9-1.91.71.71.7-2.01.81.61.41.7
Patch foraging indifference point 0 sec0.20.30.70.20.40.40.4-0.50.60.70.50.9
Patch foraging indifference point AUC0.20.31.4-0.10.40.40.40.00.50.51.20.0
Delay disc. indifference point, 0s delay1.11.22.0-1.01.41.41.4-1.20.91.00.7-0.1
Delay disc. indifference point, 16s delay0.30.31.10.10.50.50.50.00.50.71.1-0.4
Delay disc. indifference point, 2s delay0.70.81.4-0.71.11.11.1-0.80.80.91.2-0.2
Delay disc. indifference point, 24s delay0.91.02.9-0.90.91.01.0-0.31.11.11.70.4
Delay disc. indifference point, 4s delay0.91.01.7-0.61.01.01.0-1.11.01.11.30.3
Delay disc. indifference point, 8s delay0.20.31.00.10.40.40.4-0.30.50.61.0-0.5
Indifference point function ln k0.40.72.10.1-0.8-0.9-0.90.5-0.8-1.0-1.50.0
Indifference point function log k0.40.72.10.1-0.8-0.9-0.90.5-0.8-1.0-1.50.0
Patch foraging total patch changes 0 sec0.10.20.50.30.40.40.4-0.40.60.60.50.7
Patch foraging total patch changes 12 sec0.30.40.8-0.40.70.70.7-0.20.70.70.90.5
Patch foraging total patch changes 18 sec1.72.53.8-0.91.71.71.7-1.41.71.91.91.1
Patch foraging total patch changes 24 sec0.10.20.70.10.40.50.5-0.20.40.60.8-0.2
Patch foraging total patch changes 6 sec2.43.65.5-0.91.91.91.9-1.82.12.22.31.6
Patch foraging time to switch 0 sec0.10.20.5-0.10.60.70.7-0.60.20.4-0.0-0.7
Patch foraging water rate 0 sec0.20.31.8-0.10.30.20.2-0.40.60.60.61.4
Patch foraging water rate 12 sec0.30.71.21.1-0.9-1.0-1.00.9-0.7-0.6-0.7-0.3
Patch foraging water rate 18 sec0.10.10.40.40.20.10.10.10.50.50.60.5
Patch foraging water rate 24 sec0.10.10.8-0.20.0-0.1-0.10.30.20.0-0.20.9
Patch foraging water rate 6 sec1.82.63.61.8-1.8-1.9-1.91.9-1.5-1.5-1.3-0.7
Seeking ratio, delayed vs. immediate footshock0.10.21.11.1-0.4-0.4-0.40.2-0.1-0.00.0-0.2
Distance traveled before self-admin0.10.20.50.00.50.50.5-0.70.40.50.3-0.0
Distance traveled after self-admin3.23.96.2-1.02.02.02.0-2.52.02.12.01.9
Extensor digitorum longus weight0.10.51.01.0-0.6-0.6-0.60.6-0.6-0.5-0.7-0.6
Bone: elastic displacement0.00.00.0-0.1-0.1-0.1-0.10.1-0.1-0.1-0.1-0.2
Bone: elastic work2.22.84.3-2.11.91.81.8-1.61.61.51.21.4
Bone: endosteal estimation0.71.52.4-1.31.61.51.5-0.81.11.31.2-0.2
Bone: endosteal perimeter0.40.92.1-1.41.21.11.1-0.50.80.80.60.0
Epididymis fat weight0.20.84.3-2.10.80.80.8-0.60.30.1-0.30.3
Delta time in closed arm before/after self-admin0.40.40.9-0.80.40.40.4-0.90.60.40.60.9
Delta time in open arm before/after self-admin0.30.32.00.6-0.1-0.1-0.10.7-0.4-0.1-0.0-1.4
Diff in mean of infusions in LGA sessions0.81.01.4-1.20.80.80.8-0.81.10.91.11.2
Delay discount exponential model param0.60.61.80.3-0.8-0.8-0.80.6-0.8-0.9-1.30.3
Extinction: sum of active levers before priming2.12.43.0-1.71.61.61.6-1.71.51.51.50.9
Active lever presses in extinction session 60.20.20.4-0.60.50.50.5-0.40.50.50.40.2
Bone: final force3.35.26.5-2.52.52.52.5-1.92.32.22.12.0
Bone: final moment3.76.07.2-2.72.62.62.6-2.12.52.42.22.2
Food consumed during 24 hour testing period2.33.24.3-2.11.81.81.8-1.91.71.61.41.7
Glucose0.10.20.80.10.30.30.3-0.30.30.3-0.10.9
Heart weight2.94.57.9-2.82.22.22.2-2.22.01.81.22.0
Delay discount hyperbolic model param0.50.61.60.3-0.8-0.8-0.80.6-0.7-0.9-1.20.3
Intermittent access intake day 1-15 change0.30.70.91.0-0.9-1.0-1.00.6-0.7-0.7-0.90.1
Intermittent access intake escalation0.40.91.31.1-1.1-1.1-1.10.8-0.9-0.8-0.9-0.1
Intermittent access intake escalation 20.70.91.31.1-1.0-1.0-1.01.1-0.8-0.8-0.9-0.4
Intermitt. access day 1 inactive lever presses0.51.72.6-1.11.31.31.3-1.61.41.30.91.6
Intermitt. access day 15 inactive lever presses0.30.71.4-0.40.70.70.7-0.71.01.00.81.2
Intermitt. access escalation Index0.20.20.40.7-0.6-0.6-0.60.2-0.3-0.4-0.40.5
Intermittent access day 1 total infusions1.82.93.5-1.61.91.91.9-1.81.71.71.80.9
Intermittent access day 15 total infusions0.00.10.20.20.20.20.2-0.40.20.30.4-0.1
Intermittent access terminal intake (last 3 days)0.00.00.10.00.10.10.1-0.10.00.10.2-0.2
Intermittent access total infusions1.72.02.6-1.21.61.61.6-1.51.31.41.50.5
Intermittent access day 1 locomotion1.92.43.3-1.11.81.81.8-1.71.51.61.40.9
Intermittent access day 15 total locomotion0.91.72.3-1.21.51.51.5-1.21.31.41.30.6
Intermittent access total locomotion2.52.94.0-1.62.02.02.0-1.71.71.81.70.6
Intermittent access standard deviation0.51.01.4-1.01.21.21.2-1.20.91.00.50.7
Left kidney weight2.19.832.3-5.73.03.03.0-2.82.61.81.33.1
Right kidney weight2.913.440.8-6.43.63.53.5-3.43.12.31.53.6
Cocaine induced anxiety1.01.53.6-1.91.21.21.2-0.41.10.90.81.5
Post-drug Anxiety0.10.10.3-0.2-0.2-0.2-0.20.4-0.1-0.3-0.20.5
Baseline Anxiety1.72.04.42.1-1.4-1.4-1.40.8-1.3-1.1-0.8-1.7
Tail length0.20.71.91.3-0.8-0.7-0.70.2-0.8-0.7-0.6-1.4
Length with tail0.00.10.5-0.70.10.10.1-0.40.0-0.1-0.0-0.0
Length without tail0.92.87.5-2.71.61.61.6-1.41.51.21.01.7
Times rat made contact with spout0.60.71.1-1.00.70.70.7-0.80.90.70.91.1
Lifetime Intake3.64.45.6-1.92.32.32.3-2.42.12.12.11.3
Liver weight, left1.32.13.80.3-1.3-1.3-1.31.7-1.6-1.7-1.4-2.0
Liver weight, right2.84.98.40.5-2.1-2.1-2.12.3-2.5-2.7-2.9-1.9
Locomotor activity0.20.31.4-1.20.40.50.5-0.20.30.2-0.00.2
Locomotor testing distance0.00.10.10.3-0.3-0.2-0.20.3-0.2-0.2-0.2-0.1
Locomotor testing rearing0.10.10.7-0.80.10.10.1-0.4-0.0-0.1-0.30.2
Locomotion in novel chamber3.34.25.82.4-2.2-2.1-2.11.8-2.1-2.0-2.0-1.7
Locomotion in novel chamber post-restriction0.71.11.61.2-1.0-1.0-1.01.1-1.0-0.9-0.8-1.3
Fecal boli incidents, locomotor time 11.11.62.7-0.81.31.31.3-1.31.41.51.60.6
Change in fecal boli incidents, locomotor task0.40.40.9-0.1-0.7-0.7-0.70.6-0.7-0.9-0.50.2
Time >=10cm from walls, locomotor time 10.70.71.2-1.00.90.80.8-1.10.90.80.70.6
Bouts of movement, locomotor time 10.20.31.1-1.00.60.50.5-0.20.20.20.3-0.2
Total resting periods, locomotor time 10.50.51.2-1.10.80.80.8-0.40.60.60.60.3
Rest time, locomotor task time 10.91.21.7-1.31.21.21.2-0.71.01.00.91.0
Distance moved, locomotor task time 10.60.91.50.5-1.0-1.0-1.00.4-1.0-1.1-1.2-0.7
Vertical activity count, locomotor time 10.00.10.20.2-0.3-0.2-0.2-0.5-0.1-0.1-0.2-0.4
Time >=10cm from walls, locomotor time 20.20.31.1-0.20.40.40.4-0.40.50.50.41.0
Bouts of movement, locomotor time 20.00.00.2-0.3-0.1-0.1-0.10.1-0.0-0.2-0.30.4
Total resting periods, locomotor time 20.10.10.3-0.50.30.30.3-0.30.40.20.20.6
Rest time, locomotor task time 20.10.20.4-0.30.40.30.3-0.30.40.40.70.2
Distance moved, locomotor task time 20.30.41.00.3-0.6-0.5-0.50.4-0.8-0.8-1.0-0.3
Vertical activity count, locomotor time 20.10.10.7-0.30.30.30.3-0.90.20.30.1-0.0
Light reinforcement 10.00.10.1-0.10.20.20.2-0.10.30.30.40.3
Light reinforcement 20.50.81.80.1-0.9-0.9-0.91.0-0.9-1.1-1.3-0.0
Bone: marrow area0.81.82.8-1.41.71.61.6-0.91.21.41.3-0.0
Bone: maximum diameter2.95.59.0-3.02.52.52.5-2.22.32.11.81.9
Bone: maximum force4.98.610.2-3.23.13.13.1-2.73.02.92.72.5
Bone: maximum moment5.39.311.0-3.33.23.23.2-2.73.13.02.82.7
Mean time between licks in bursts0.20.51.01.0-0.7-0.7-0.70.6-0.6-0.5-0.7-0.4
Mean num. licks in bursts0.20.21.4-1.20.40.40.4-0.10.30.20.10.1
Cd content in liver0.20.20.8-0.90.20.20.20.00.20.00.30.9
Co content in liver1.41.63.4-0.91.11.11.1-1.31.31.21.21.9
Cu content in liver0.30.42.81.7-0.1-0.1-0.10.40.10.40.5-0.1
Fe content in liver2.02.44.1-1.41.71.71.7-2.01.51.61.21.0
K content in liver0.40.41.01.0-0.7-0.7-0.70.5-0.4-0.4-0.30.2
Mg content in liver0.10.10.40.50.0-0.0-0.00.20.30.40.40.6
Mn content in liver0.80.91.50.6-1.0-1.0-1.01.2-0.9-1.0-0.8-0.6
Na content in liver0.20.21.31.1-0.3-0.2-0.20.1-0.20.0-0.0-0.5
Rb content in liver2.12.43.0-1.31.51.51.5-1.51.61.61.71.6
Se content in liver1.21.51.71.2-1.3-1.3-1.31.3-1.2-1.2-1.2-0.7
Sr content in liver1.71.52.91.7-1.3-1.3-1.31.0-1.1-1.1-1.0-0.7
Zn content in liver0.10.10.70.2-0.2-0.2-0.20.8-0.1-0.10.00.1
Bone: minimum diameter0.71.31.9-1.21.41.41.4-0.61.11.21.10.2
Time in familiar zone, hab. session 10.80.81.6-0.90.90.90.9-0.60.90.91.30.3
Time in novel zone, hab. session 10.40.41.60.4-0.5-0.5-0.50.1-0.7-0.7-1.3-0.3
Total zone transitions, hab. session 12.23.15.42.3-1.8-1.8-1.81.8-1.5-1.3-0.6-2.3
Total locomotion distance, hab. session 12.73.86.92.2-1.9-1.9-1.91.9-1.9-1.7-1.1-2.6
Locomotion velocity, hab. session 11.72.44.92.0-1.5-1.5-1.51.5-1.4-1.1-0.6-2.2
Time in familiar zone, hab. session 22.22.33.61.1-1.4-1.4-1.41.9-1.6-1.5-1.5-1.7
Time in novel zone, hab. session 21.81.83.3-1.01.31.31.3-1.81.31.31.31.4
Total zone transitions, hab. session 20.70.93.00.00.90.90.9-0.71.11.21.70.2
Total locomotion distance, hab. session 20.40.51.30.30.60.60.6-0.60.80.91.10.3
Locomotion velocity, hab. session 20.40.61.70.50.60.60.6-0.60.81.01.30.2
Novel to familiar place preference ratio0.10.20.7-0.8-0.1-0.1-0.1-0.0-0.2-0.4-0.60.1
Novelty place preference0.30.30.8-0.9-0.3-0.3-0.30.2-0.4-0.7-0.90.1
Time in novel zone, NPP test0.30.31.2-1.1-0.2-0.2-0.20.1-0.3-0.7-0.80.2
Total zone transitions, NPP test0.81.23.21.8-1.1-1.1-1.11.2-0.8-0.60.1-1.2
Total locomotion distance, NPP test0.20.21.11.0-0.4-0.4-0.40.4-0.2-0.00.4-0.3
Locomotion velocity, NPP test0.40.52.11.5-0.7-0.7-0.70.7-0.5-0.30.2-0.7
Intraocular pressure0.10.10.7-0.4-0.1-0.1-0.1-0.2-0.2-0.20.0-0.9
Delta distance traveled before/after self-admin1.81.92.4-1.21.41.41.4-1.51.41.31.41.5
Delta ambulatory time before/after self-admin2.12.63.6-1.51.61.61.6-1.71.61.51.71.9
Parametrial fat weight0.71.82.70.8-1.4-1.3-1.31.1-1.5-1.4-1.4-1.7
Pavlov. Cond. lever latency0.00.10.3-0.50.20.20.2-0.10.0-0.0-0.00.3
Pavlov. Cond. magazine entry latency0.10.20.40.00.30.30.3-0.30.50.50.70.3
Pavlov. Cond. change in total contacts1.21.32.4-0.21.01.01.0-1.01.31.41.51.2
Pavlov. Cond. index score0.20.30.6-0.20.50.50.5-0.50.60.70.80.3
Pavlov. Cond. latency score0.10.10.2-0.00.30.30.3-0.30.40.50.50.2
Pavlov. Cond. lever contacts0.10.10.60.8-0.1-0.1-0.10.20.00.20.2-0.4
Pavlov. Cond. magazine entry number0.10.10.5-0.1-0.3-0.3-0.30.3-0.4-0.5-0.7-0.2
Pavlov. Cond. intertrial magazine entries0.40.50.90.20.60.60.6-0.60.70.91.00.5
Pavlov. Cond. lever-magazine prob. diff.0.10.10.4-0.00.30.30.3-0.20.50.50.60.3
Pavlov. Cond. response bias0.10.20.50.20.30.30.3-0.30.50.50.70.2
Pavlov. Cond. lever latency0.20.20.9-0.4-0.3-0.3-0.30.4-0.5-0.6-0.3-1.0
Pavlov. Cond. magazine entry latency1.11.32.30.21.11.11.1-1.21.31.51.50.7
Pavlov. Cond. change in total contacts2.84.57.1-1.22.12.12.1-1.92.42.42.12.7
Pavlov. Cond. index score0.50.71.20.30.70.70.7-0.81.01.11.00.9
Pavlov. Cond. latency score0.60.71.30.40.70.70.7-0.81.01.11.11.0
Pavlov. Cond. lever contacts0.10.20.70.60.20.20.2-0.30.40.50.30.8
Pavlov. Cond. magazine entry number0.50.61.2-0.1-0.7-0.7-0.70.7-0.9-1.0-1.1-0.7
Pavlov. Cond. intertrial magazine entries0.60.92.3-1.50.90.90.9-0.80.80.60.51.3
Pavlov. Cond. lever-magazine prob. diff.0.40.61.10.40.70.70.7-0.70.91.00.90.8
Pavlov. Cond. response bias0.60.91.40.10.90.90.9-0.91.11.21.01.1
Time in closed arm before self-admin0.40.51.51.20.60.70.7-0.40.50.90.7-0.5
Time in closed arm after self-admin0.60.61.6-0.50.90.90.9-1.30.60.70.7-0.1
Time in open arm before self-admin1.31.41.90.6-1.3-1.4-1.41.2-1.2-1.4-1.2-0.4
Time in open arm after self-admin1.21.31.71.1-1.1-1.1-1.11.3-1.2-1.1-1.0-1.3
Bone: periosteal estimation1.53.14.3-2.02.12.12.1-1.31.71.81.60.8
Bone: periosteal perimeter1.22.15.0-2.21.71.71.7-1.01.31.20.90.7
Bone: post-yield work2.74.04.9-1.82.02.02.0-2.02.12.12.21.7
Progressive ratio test 1 active lever presses2.12.63.2-1.51.81.81.8-1.61.61.61.80.9
Progressive ratio test 1 breakpoint1.72.02.6-1.31.61.61.6-1.41.41.41.60.8
Progressive ratio test 1 inactive lever presses2.13.14.2-1.32.02.02.0-1.71.81.91.71.2
Progressive ratio test 2 active lever presses1.82.13.3-1.31.51.51.5-1.31.51.51.80.9
Progressive ratio test 2 breakpoint1.61.83.0-1.21.41.41.4-1.21.41.41.70.8
Progressive ratio test 2 inactive lever presses0.20.30.60.10.50.50.5-0.70.40.70.8-0.2
Incentive Sensitization - Responses0.00.00.10.1-0.2-0.2-0.20.20.00.00.20.2
Incentive Sensitization - Breakpoint0.00.00.2-0.0-0.0-0.1-0.10.00.20.10.30.4
Sum of active levers in priming session hrs 5-60.00.00.0-0.1-0.0-0.0-0.00.20.0-0.0-0.1-0.1
Progressive ratio0.10.10.3-0.10.50.50.5-0.20.40.50.40.0
Food seeking constrained by brief footshock0.81.01.8-1.41.01.11.1-0.90.90.80.81.0
Seeking ratio, punishment vs. effort0.30.50.9-0.90.60.60.6-0.80.60.50.60.8
Retroperitoneal fat weight0.41.810.0-3.20.91.01.0-1.20.60.1-0.41.2
Reaction time number correct1.52.93.51.7-1.9-1.9-1.91.9-1.7-1.6-1.3-1.5
Reaction time mean minus median0.10.20.80.2-0.1-0.2-0.20.3-0.4-0.3-0.5-0.9
Reaction time mean minus median AUC0.10.40.9-0.0-0.3-0.4-0.40.3-0.7-0.7-0.9-1.0
Reaction time num false alarms0.20.30.40.7-0.5-0.5-0.50.6-0.6-0.5-0.6-0.6
Reaction time num false alarms AUC0.50.80.91.0-0.9-0.8-0.80.9-0.9-0.8-0.8-0.9
Reaction time trials correct on left1.52.93.51.7-1.9-1.9-1.91.9-1.7-1.6-1.3-1.5
Reaction time trials on left1.63.13.71.7-1.9-1.9-1.91.9-1.7-1.7-1.4-1.5
Reaction time mean0.10.10.30.6-0.3-0.4-0.40.1-0.4-0.3-0.6-0.2
Reaction time mean AUC0.10.10.30.5-0.3-0.3-0.30.1-0.4-0.3-0.5-0.2
Median of all reaction times0.10.10.40.6-0.3-0.4-0.40.0-0.3-0.3-0.50.1
Reaction time omissions0.40.61.10.9-0.7-0.7-0.70.9-0.8-0.7-0.5-1.0
Reaction time false alarm rate0.00.00.10.10.00.00.00.1-0.1-0.1-0.3-0.0
Reaction time premature initiation rate2.23.15.1-1.01.61.61.6-2.01.91.91.72.3
Reaction time premature initiations0.50.82.1-0.30.70.60.6-1.01.01.01.01.5
Std. dev. reaction times0.10.20.50.2-0.3-0.3-0.30.2-0.5-0.5-0.7-0.6
Reaction time trials completed1.63.13.71.7-1.9-1.9-1.91.9-1.7-1.7-1.4-1.5
Reaction time trials AUC1.22.32.81.5-1.7-1.7-1.71.7-1.5-1.5-1.2-1.4
Run reversals in cocaine runway, females0.50.50.80.8-0.8-0.8-0.80.9-0.7-0.7-0.6-0.4
Run reversals in cocaine runway, males0.10.10.6-0.70.10.10.10.1-0.2-0.20.2-0.8
Latency to leave start box in cocaine runway0.20.20.5-0.1-0.3-0.4-0.40.4-0.5-0.5-0.7-0.1
Latency to leave start box in cocaine runway, F0.10.10.20.2-0.2-0.3-0.30.4-0.3-0.2-0.3-0.2
Latency to leave start box in cocaine runway, M0.30.30.9-0.2-0.4-0.4-0.40.2-0.6-0.7-0.90.1
Std. dev. time between licks in bursts0.60.81.20.20.70.70.7-1.01.01.11.11.0
Total sessions with >9 infusions5.97.110.1-3.02.62.62.6-3.22.62.32.13.0
Short access day 1 total inactive lever presses7.810.212.4-2.53.43.43.4-3.53.43.43.22.5
Short access day 10 total inactive lever presses0.10.20.3-0.60.50.50.50.20.30.40.2-0.2
Short access day 1 total infusions2.83.74.8-1.72.12.02.0-2.22.01.81.61.9
Short access day 10 total infusions3.03.95.7-2.02.12.12.1-2.41.81.81.61.6
Short access total infusions6.78.511.5-2.83.13.03.0-3.42.92.72.62.6
Short access day 1 locomotion0.91.11.7-0.91.11.11.1-1.31.01.00.61.2
Short access day 10 total locomotion0.20.41.20.00.80.80.8-1.10.60.70.20.3
Short access total locomotion2.02.44.5-1.41.71.71.7-2.11.41.40.91.5
One hour access (0.3 mA shock)0.10.10.2-0.00.40.40.4-0.40.30.50.4-0.1
Compulsive drug intake0.10.10.30.0-0.4-0.4-0.40.00.2-0.00.50.4
One hour access (shock baseline)0.10.10.20.00.50.50.5-0.40.10.40.0-0.3
Social response proportion0.40.41.4-0.30.40.40.4-1.20.50.4-0.21.2
Social responses0.00.00.10.10.20.10.1-0.30.20.30.40.1
Social time0.10.11.01.0-0.0-0.1-0.10.10.00.20.3-0.3
Soleus weight0.20.51.1-0.30.50.50.5-0.50.80.71.10.9
Bone: stiffness3.45.66.5-2.42.52.52.5-2.22.42.42.12.0
Tibialis anterior weight0.00.10.50.70.10.10.1-0.00.30.50.50.0
Time to tail flick, vehicle, before self-admin0.40.40.5-0.40.70.70.7-0.40.60.70.60.5
Time to tail flick, vehicle, after self-admin0.40.52.11.0-0.4-0.4-0.40.7-0.5-0.2-0.1-1.5
Time to tail flick, test, before self-admin0.30.30.5-0.1-0.4-0.4-0.40.7-0.7-0.7-0.6-0.4
Time to tail flick, test, after self-admin0.30.40.50.7-0.6-0.6-0.60.7-0.6-0.5-0.5-0.5
Delta time to tail flick, vehicle, before/after SA0.10.10.2-0.10.30.30.3-0.50.30.30.3-0.3
Delta time to tail flick, test, before/after SA0.50.52.11.5-0.7-0.7-0.70.5-0.4-0.3-0.3-0.4
Tibia length0.82.14.0-2.01.51.41.4-1.01.41.21.41.5
Ambulatory time before self-admin0.10.10.40.6-0.2-0.2-0.2-0.1-0.2-0.1-0.1-0.6
Ambulatory time after self-admin1.11.32.40.01.01.01.0-1.61.21.21.41.0
Bone: tissue strength0.10.10.4-0.40.10.10.1-0.10.10.00.00.6
Total heroin consumption1.11.31.6-1.21.01.11.1-1.11.21.11.31.1
Bone: trabecular number0.20.30.70.4-0.6-0.6-0.60.8-0.6-0.6-0.6-0.2
Bone: trabecular spacing2.83.75.3-2.12.02.02.0-2.31.91.81.91.1
Bone: trabecular thickness0.50.71.51.0-0.6-0.7-0.71.2-0.8-0.7-1.0-0.4
Bone: trabecular tissue density0.10.21.31.1-0.2-0.2-0.20.10.00.2-0.10.4
Water consumed over 24 hours0.91.21.3-1.21.11.11.1-1.21.11.01.11.0
Number of responses in last shaping day3.13.44.9-0.82.02.02.0-2.02.02.21.91.2