Hub : Genes

Mrpl42

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA mRNA stability Mrpl42 0.06 0.04 7.5e-03 0.02 0.03 0.01 0.02 4.5e-02 9.8e-03 7.7e-02 4.1e-02
2 Adipose mRNA stability Mrpl42 0.07 0.04 1.1e-03 0.03 0.03 0.03 0.03 2.9e-04 3.5e-04 4.0e-04 7.2e-04
3 PL mRNA stability Mrpl42 0.09 0.04 4.9e-07 0.09 0.05 0.07 0.08 4.1e-10 4.0e-06 5.3e-08 2.0e-09
4 NAcc gene expression Mrpl42 0.1 0.04 4.2e-12 0.12 0.1 0.11 0.11 2.5e-13 4.6e-11 2.2e-12 1.7e-12
5 Liver gene expression Mrpl42 0.19 0.08 1.4e-08 0.06 0.07 0.08 0.08 1.8e-07 1.2e-08 3.9e-09 1.4e-09
6 NAcc intron excision ratio chr7_30118152_30127861 0.04 0.02 5.4e-03 0.02 0.02 0.02 0.02 1.2e-03 5.2e-03 3.8e-03 5.0e-03
7 Brain gene expression Mrpl42 0.29 0.08 0.0e+00 0.24 0.22 0.24 0.24 7.7e-22 3.4e-20 6.0e-22 1.7e-22
8 OFC isoform ratio XR_005486574.1 0.21 0.11 3.7e-03 0.13 0.11 0.07 0.1 4.9e-04 1.3e-03 1.0e-02 2.1e-03
9 Adipose gene expression Mrpl42 0.1 0.04 2.1e-09 0.06 0.06 0.05 0.06 7.8e-07 1.7e-07 1.3e-06 1.2e-07
10 BLA gene expression Mrpl42 0.28 0.09 3.8e-08 0.14 0.13 0.14 0.17 4.4e-08 2.0e-07 4.7e-08 2.7e-09
11 PL gene expression Mrpl42 0.14 0.05 6.0e-14 0.15 0.11 0.12 0.12 5.0e-16 9.2e-12 1.2e-12 1.5e-13
12 OFC gene expression Mrpl42 0.22 0.11 3.3e-03 0.11 0.06 0.06 0.08 1.3e-03 1.3e-02 1.3e-02 6.9e-03
13 PL isoform ratio XR_005486574.1 0.08 0.04 2.9e-06 0.06 0.05 0.04 0.05 8.6e-07 1.8e-06 8.9e-06 2.6e-06
14 pVTA gene expression Mrpl42 0.2 0.07 6.8e-09 0.17 0.13 0.11 0.13 6.6e-08 2.3e-06 1.7e-05 2.9e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.50.81.9-0.8-0.00.00.7-0.6-0.3-0.70.2-1.1-1.41.41.41.01.1
Area under the delay curve1.01.12.4-0.0-0.9-0.70.8-0.8-0.9-1.00.8-1.1-1.21.21.21.41.6
BMI with tail0.20.72.80.40.0-0.0-0.10.10.90.3-0.10.41.0-1.0-1.0-1.6-1.7
BMI without tail0.51.03.3-1.81.81.60.5-0.50.7-0.20.1-0.60.1-0.1-0.1-1.0-1.6
Body weight1.56.340.7-6.44.54.30.1-0.10.80.3-0.3-1.00.7-0.7-0.7-1.3-1.8
Weight adjusted by age1.82.02.8-0.70.71.0-1.71.61.51.6-1.51.51.5-1.5-1.5-1.5-1.6
Bone surface0.10.20.7-0.6-0.2-0.1-0.50.50.60.5-0.90.00.1-0.1-0.1-0.10.0
Bone volume0.10.10.4-0.6-0.1-0.0-0.00.00.5-0.1-0.1-0.4-0.50.50.50.20.4
Breakpoint value in progressive ratio session1.31.42.11.4-0.7-0.7-1.31.31.31.2-1.11.51.3-1.3-1.3-1.2-0.7
Number of licking bursts0.40.42.60.9-1.6-1.50.2-0.20.1-0.20.1-0.1-0.10.10.1-0.0-0.1
Context. condit. distance diff. score0.81.01.4-1.01.11.11.1-1.1-0.8-1.01.1-1.2-0.90.90.90.60.7
Locomotion velocity, session 11.01.01.81.1-1.2-1.2-1.31.30.91.0-0.91.30.9-0.9-0.9-0.4-0.4
Locomotion distance, session 10.91.12.10.6-1.2-1.1-1.41.30.51.1-0.81.41.3-1.3-1.3-0.2-0.2
Locomotion velocity, session 20.40.41.9-1.41.21.2-0.40.40.10.2-0.10.10.2-0.2-0.20.40.6
Locomotion distance, session 21.01.43.5-0.5-0.6-0.7-1.91.71.21.2-0.91.41.4-1.4-1.4-0.7-0.3
Locomotion velocity, session 30.50.62.2-1.51.51.50.1-0.1-0.0-0.20.1-0.4-0.50.50.50.60.3
Locomotion distance, session 30.10.10.4-0.3-0.1-0.10.4-0.4-0.6-0.50.6-0.4-0.30.30.30.30.1
Stereotopy head waving bouts, day 32.02.44.2-1.31.81.8-1.91.82.01.7-1.81.31.2-1.2-1.2-1.0-1.0
Stereotopy head waving duration, day 31.01.23.7-1.21.91.9-0.91.01.40.9-1.20.60.5-0.5-0.5-0.6-0.6
Locomotion velocity, session 70.10.20.5-0.50.20.1-0.70.70.20.5-0.70.20.1-0.1-0.10.1-0.2
Locomotion distance, session 70.30.31.10.2-1.0-1.1-0.20.1-0.5-0.10.2-0.2-0.30.30.30.91.0
Stereotopy head waving bouts, day 70.30.41.8-1.21.41.30.1-0.1-0.0-0.1-0.1-0.0-0.30.30.30.20.1
Stereotopy head waving duration, day 70.20.20.4-0.20.60.60.6-0.6-0.4-0.50.3-0.2-0.50.50.50.30.2
Locomotion velocity, session 80.60.73.4-1.21.81.8-0.10.0-0.1-0.00.30.20.5-0.5-0.5-0.4-0.2
Locomotion distance, session 80.60.94.3-2.11.21.1-1.00.90.90.7-0.50.30.7-0.7-0.7-0.6-0.3
Degree of sensitization distance0.30.30.60.4-0.5-0.6-0.80.80.30.6-0.60.40.4-0.4-0.40.20.4
Degree of sensitization stereotypy0.90.91.8-0.00.20.21.2-1.2-1.3-1.11.1-0.8-1.11.11.11.01.0
Conditioned locomotion0.40.51.3-0.70.0-0.00.3-0.3-0.6-0.50.4-0.8-0.80.80.81.11.1
Cocaine response after cond. corrected0.30.30.7-0.1-0.2-0.20.7-0.7-0.8-0.60.6-0.8-0.70.70.70.40.2
Cocaine response after cond. not corrected0.20.20.4-0.1-0.4-0.40.5-0.5-0.5-0.40.4-0.6-0.50.50.50.30.2
Cocaine response before conditioning0.50.60.90.6-0.5-0.5-0.70.70.80.8-0.81.00.9-0.9-0.9-0.7-0.5
Saline control response0.30.31.9-1.41.11.0-0.20.3-0.10.4-0.50.00.1-0.1-0.1-0.2-0.2
Bone: connectivity density0.30.52.0-0.80.30.3-1.01.00.41.0-1.40.40.3-0.3-0.3-0.0-0.0
Bone: cortical apparent density0.20.30.8-0.6-0.3-0.10.2-0.3-0.6-0.60.7-0.4-0.40.40.40.90.8
Bone: cortical area0.60.91.4-0.2-1.2-1.11.0-1.0-0.5-1.00.8-1.0-1.11.11.10.80.9
Bone: cortical porosity0.70.84.1-1.52.01.90.2-0.2-0.3-0.10.0-0.3-0.20.20.20.30.1
Bone: cortical porosity0.40.52.6-1.31.61.50.00.00.10.1-0.3-0.2-0.10.10.10.0-0.2
Bone: cortical thickness0.81.32.1-0.6-0.7-0.61.2-1.2-1.1-1.21.1-1.1-1.31.31.31.41.4
Bone: cortical thickness0.70.81.00.7-0.9-0.81.0-1.0-0.7-1.00.9-0.7-0.90.90.90.90.8
Bone: cortical tissue density0.20.30.8-0.7-0.1-0.00.2-0.3-0.5-0.50.7-0.4-0.40.40.40.90.8
Condit. Reinf. active minus inactive responses1.11.34.32.1-1.6-1.7-0.90.90.81.0-1.31.10.5-0.5-0.5-0.7-0.8
Condit. Reinf. active-inactive response ratio0.80.94.62.1-1.8-1.7-0.20.20.20.4-0.80.4-0.10.10.1-0.4-0.7
Condit. Reinf. active responses1.31.55.92.4-1.7-1.8-0.90.91.11.0-1.21.20.6-0.6-0.6-0.9-0.9
Condit. Reinf. inactive responses0.30.41.91.4-0.6-0.6-0.40.40.70.4-0.20.80.6-0.6-0.6-0.5-0.2
Incentive salience index mean2.02.43.91.6-1.6-1.7-1.71.71.91.7-2.01.71.0-1.0-1.0-1.3-1.3
Condit. Reinf. lever presses1.62.14.30.3-0.8-0.9-1.91.92.11.7-1.81.61.2-1.2-1.2-1.4-1.1
Condit. Reinf. active minus inactive responses0.60.72.00.80.30.3-0.80.80.50.9-0.81.41.0-1.0-1.0-0.6-0.6
Condit. Reinf. active-inactive response ratio0.20.20.90.20.91.00.5-0.5-0.1-0.40.50.30.1-0.1-0.1-0.1-0.0
Condit. Reinf. active responses0.71.02.41.2-0.4-0.4-1.01.00.41.0-0.81.61.3-1.3-1.3-0.5-0.5
Condit. Reinf. inactive responses1.01.32.61.6-1.4-1.5-1.21.20.21.0-0.71.31.3-1.3-1.3-0.2-0.1
Condit. Reinf. lever presses2.33.15.20.11.31.2-1.81.71.31.7-1.32.32.3-2.3-2.3-2.0-1.8
Condit. Reinf. lever reinforcers received0.50.82.01.4-0.6-0.6-0.80.80.10.8-0.51.41.1-1.1-1.1-0.4-0.3
Conditioned reinforcement - actives2.82.85.0-2.01.61.6-1.81.82.21.7-1.81.51.6-1.6-1.6-1.5-0.8
Conditioned reinforcement - inactives1.82.05.6-2.41.01.0-1.81.81.81.6-1.90.80.9-0.9-0.9-1.2-0.3
Conditioned locomotion0.70.85.3-2.31.21.1-0.80.80.70.7-0.80.00.4-0.4-0.4-0.40.1
Patch foraging indifference point 0 sec1.01.62.3-1.20.70.71.1-1.2-1.2-1.41.4-1.4-1.51.51.51.41.3
Patch foraging indifference point AUC0.20.31.6-1.30.80.8-0.30.30.50.3-0.40.10.2-0.2-0.2-0.1-0.1
Delay disc. indifference point, 0s delay0.40.40.7-0.70.60.8-0.90.90.50.8-0.80.70.5-0.5-0.5-0.4-0.0
Delay disc. indifference point, 16s delay1.92.03.10.3-1.5-1.31.1-1.1-1.2-1.31.1-1.6-1.61.61.61.81.8
Delay disc. indifference point, 2s delay0.30.30.6-0.80.60.7-0.60.60.60.6-0.50.50.6-0.6-0.6-0.5-0.1
Delay disc. indifference point, 24s delay1.81.72.7-0.4-0.5-0.31.2-1.2-1.3-1.41.2-1.6-1.61.61.61.61.6
Delay disc. indifference point, 4s delay0.20.20.40.0-0.2-0.00.6-0.6-0.6-0.50.6-0.4-0.40.40.40.60.6
Delay disc. indifference point, 8s delay1.91.93.50.1-0.8-0.71.4-1.4-1.5-1.51.4-1.5-1.51.51.51.61.9
Indifference point function ln k0.60.81.31.1-1.0-1.01.0-0.9-1.1-0.80.7-0.9-0.90.90.90.60.4
Indifference point function log k0.60.81.31.1-1.0-1.01.0-0.9-1.1-0.80.7-0.9-0.90.90.90.60.4
Patch foraging total patch changes 0 sec0.91.52.0-1.20.60.61.0-1.0-1.3-1.21.3-1.3-1.41.41.41.41.3
Patch foraging total patch changes 12 sec0.20.21.4-1.20.80.7-0.40.40.30.3-0.30.30.1-0.1-0.10.0-0.4
Patch foraging total patch changes 18 sec0.70.92.9-1.70.90.80.8-0.8-0.5-1.01.1-1.0-1.01.01.00.70.6
Patch foraging total patch changes 24 sec0.91.12.6-1.61.41.50.9-1.0-0.6-1.01.0-0.9-0.90.90.90.40.4
Patch foraging total patch changes 6 sec0.40.71.30.1-0.0-0.11.0-1.0-1.0-1.11.1-0.7-0.80.80.80.90.5
Patch foraging time to switch 0 sec0.10.20.4-0.20.30.4-0.60.60.30.5-0.30.60.6-0.6-0.6-0.3-0.3
Patch foraging water rate 0 sec0.10.10.6-0.5-0.1-0.2-0.10.10.80.2-0.4-0.1-0.00.00.0-0.5-0.5
Patch foraging water rate 12 sec0.10.21.4-1.20.60.50.1-0.10.3-0.1-0.1-0.6-0.40.40.4-0.2-0.3
Patch foraging water rate 18 sec0.50.62.00.40.1-0.1-0.70.80.90.9-1.10.50.6-0.6-0.6-1.1-1.4
Patch foraging water rate 24 sec0.20.31.7-1.30.70.6-0.20.20.80.3-0.5-0.3-0.00.00.0-0.8-0.6
Patch foraging water rate 6 sec2.23.26.1-1.81.51.3-1.61.72.11.8-2.01.01.6-1.6-1.6-2.5-2.3
Seeking ratio, delayed vs. immediate footshock0.20.21.0-0.1-0.6-1.0-0.30.30.20.1-0.4-0.2-0.50.50.50.30.1
Distance traveled before self-admin2.12.23.1-0.00.40.5-1.71.71.71.7-1.61.71.7-1.7-1.7-1.6-1.5
Distance traveled after self-admin0.20.20.9-0.6-0.2-0.20.1-0.1-0.2-0.20.1-0.4-0.50.50.50.50.9
Extensor digitorum longus weight0.00.20.4-0.60.60.6-0.10.10.40.2-0.10.10.4-0.4-0.4-0.5-0.4
Bone: elastic displacement0.40.54.42.1-0.3-0.4-0.00.0-0.20.2-0.10.90.6-0.6-0.6-0.4-0.4
Bone: elastic work1.41.83.11.2-0.3-0.41.6-1.6-1.8-1.61.6-1.0-1.31.31.31.51.4
Bone: endosteal estimation0.20.41.10.9-1.1-1.00.5-0.50.1-0.40.4-0.8-0.50.50.5-0.1-0.0
Bone: endosteal perimeter0.20.41.50.4-1.2-1.10.5-0.50.5-0.40.3-0.9-0.50.50.5-0.5-0.4
Epididymis fat weight0.10.30.9-0.70.60.50.9-0.8-0.3-0.50.4-0.7-0.30.30.3-0.1-0.6
Delta time in closed arm before/after self-admin0.30.31.21.0-0.6-0.6-0.20.20.20.4-0.40.50.5-0.5-0.5-0.5-1.1
Delta time in open arm before/after self-admin0.10.10.10.20.30.30.1-0.10.1-0.20.2-0.2-0.30.30.30.30.3
Diff in mean of infusions in LGA sessions0.30.43.21.8-0.8-1.00.0-0.1-0.3-0.00.20.50.1-0.1-0.1-0.10.1
Delay discount exponential model param1.21.32.70.10.80.6-1.01.01.01.1-1.01.31.3-1.3-1.3-1.4-1.6
Extinction: sum of active levers before priming0.70.71.41.2-1.0-1.00.8-0.8-0.8-0.80.8-0.5-0.80.80.80.80.6
Active lever presses in extinction session 61.91.82.80.8-0.6-0.7-1.51.61.71.5-1.41.51.5-1.5-1.5-1.5-1.3
Bone: final force3.65.88.30.3-1.8-1.82.6-2.6-1.8-2.72.5-2.7-2.92.92.92.42.5
Bone: final moment3.15.17.40.4-1.9-1.92.4-2.3-1.7-2.42.1-2.4-2.72.72.72.42.4
Food consumed during 24 hour testing period0.81.02.5-0.20.30.21.6-1.5-1.1-1.21.1-1.3-1.01.01.00.60.6
Glucose0.00.10.20.5-0.4-0.40.1-0.10.3-0.10.10.10.0-0.0-0.0-0.2-0.0
Heart weight0.30.40.9-0.2-0.7-0.80.3-0.2-0.1-0.30.1-0.7-0.80.80.80.81.0
Delay discount hyperbolic model param0.50.61.40.30.50.3-0.60.60.60.7-0.60.80.8-0.8-0.8-1.0-1.2
Intermittent access intake day 1-15 change2.72.73.9-0.80.80.9-1.71.71.81.8-1.71.82.0-2.0-2.0-2.0-1.5
Intermittent access intake escalation2.22.23.2-0.60.40.5-1.51.51.61.6-1.51.71.8-1.8-1.8-1.8-1.3
Intermittent access intake escalation 21.01.01.5-0.50.20.2-1.11.11.21.1-1.11.11.2-1.2-1.2-1.1-0.7
Intermitt. access day 1 inactive lever presses0.80.91.40.6-0.3-0.20.9-0.9-0.9-1.00.9-0.7-1.21.21.21.11.1
Intermitt. access day 15 inactive lever presses0.10.10.4-0.30.50.60.2-0.2-0.1-0.20.1-0.1-0.40.40.40.20.6
Intermitt. access escalation Index0.40.31.81.30.10.1-0.30.30.30.3-0.20.80.6-0.6-0.6-0.4-0.8
Intermittent access day 1 total infusions0.50.62.8-1.71.41.4-0.10.10.20.10.1-0.00.5-0.5-0.5-0.4-0.3
Intermittent access day 15 total infusions2.12.45.8-2.41.81.9-1.31.21.41.3-1.11.01.7-1.7-1.7-1.6-1.0
Intermittent access terminal intake (last 3 days)1.92.05.2-2.32.12.1-1.01.01.11.1-0.80.91.5-1.5-1.5-1.4-0.8
Intermittent access total infusions0.91.04.8-2.21.71.7-0.40.30.50.4-0.20.30.8-0.8-0.8-0.7-0.6
Intermittent access day 1 locomotion1.01.04.5-2.11.01.00.6-0.7-0.5-0.80.8-1.3-0.80.80.80.81.2
Intermittent access day 15 total locomotion1.51.611.8-3.41.61.60.5-0.5-0.4-0.50.4-1.1-0.70.70.70.71.0
Intermittent access total locomotion1.31.59.1-3.01.91.90.6-0.6-0.4-0.60.6-1.1-0.50.50.50.50.6
Intermittent access standard deviation1.21.33.6-1.90.80.8-1.21.21.51.2-1.20.71.0-1.0-1.0-1.1-0.6
Left kidney weight0.30.86.9-2.61.41.50.2-0.2-0.2-0.10.1-0.40.1-0.1-0.10.0-0.3
Right kidney weight0.51.36.5-2.52.12.1-0.20.30.30.5-0.50.10.7-0.7-0.7-0.5-0.7
Cocaine induced anxiety2.42.84.71.4-1.6-1.61.8-1.8-1.2-1.81.8-1.4-1.61.61.61.82.2
Post-drug Anxiety1.61.72.71.6-1.0-1.01.5-1.5-1.0-1.51.7-0.8-1.21.21.21.41.5
Baseline Anxiety0.20.21.1-0.51.01.00.0-0.0-0.10.0-0.00.10.1-0.1-0.1-0.1-0.5
Tail length2.57.551.5-7.25.15.00.00.00.40.2-0.6-1.3-0.20.20.2-0.0-0.7
Length with tail3.011.180.3-9.06.05.90.10.00.20.2-0.5-1.5-0.10.10.1-0.0-0.4
Length without tail1.22.620.2-4.52.82.8-0.20.3-0.00.3-0.3-0.50.1-0.1-0.10.00.1
Times rat made contact with spout0.80.92.8-0.1-1.7-1.50.8-0.7-0.5-0.60.3-0.9-1.21.21.20.60.5
Lifetime Intake0.70.73.6-1.91.41.4-0.40.30.50.4-0.20.20.7-0.7-0.7-0.7-0.3
Liver weight, left1.01.63.0-0.10.40.3-1.41.41.71.5-1.71.11.2-1.2-1.2-1.4-1.7
Liver weight, right1.62.74.3-1.81.91.7-1.71.71.81.8-2.11.31.6-1.6-1.6-1.0-1.3
Locomotor activity0.50.92.8-1.70.40.2-1.11.11.21.0-1.10.50.7-0.7-0.7-0.9-0.7
Locomotor testing distance0.30.51.10.2-0.9-1.0-0.70.71.00.7-0.80.50.4-0.4-0.4-0.9-0.9
Locomotor testing rearing0.50.82.4-0.4-0.1-0.1-1.11.01.50.8-0.70.70.7-0.7-0.7-1.4-1.1
Locomotion in novel chamber0.30.30.80.0-0.6-0.7-0.80.80.80.7-0.90.40.2-0.2-0.2-0.2-0.4
Locomotion in novel chamber post-restriction0.60.71.6-1.31.21.0-0.70.70.90.7-0.60.40.8-0.8-0.8-0.8-0.6
Fecal boli incidents, locomotor time 10.00.00.4-0.60.10.4-0.00.00.1-0.10.1-0.2-0.10.10.10.10.1
Change in fecal boli incidents, locomotor task2.92.83.71.5-1.5-1.71.7-1.7-1.4-1.81.7-1.5-1.71.71.71.71.9
Time >=10cm from walls, locomotor time 10.20.21.51.2-0.10.10.3-0.3-0.2-0.20.30.20.1-0.1-0.1-0.1-0.5
Bouts of movement, locomotor time 10.10.20.50.0-0.2-0.2-0.70.70.30.6-0.60.20.2-0.2-0.2-0.3-0.0
Total resting periods, locomotor time 10.20.20.50.1-0.3-0.2-0.70.70.30.6-0.70.30.2-0.2-0.2-0.20.1
Rest time, locomotor task time 10.30.30.60.30.80.8-0.60.60.60.6-0.60.80.5-0.5-0.5-0.5-0.6
Distance moved, locomotor task time 10.60.71.2-0.50.50.4-0.80.81.10.8-0.90.90.9-0.9-0.9-0.9-1.1
Vertical activity count, locomotor time 10.70.70.90.2-0.6-0.6-0.90.90.90.9-0.90.90.9-0.9-0.9-0.8-0.9
Time >=10cm from walls, locomotor time 20.60.61.61.3-0.8-0.80.8-0.8-0.8-0.90.9-0.0-0.70.70.70.70.3
Bouts of movement, locomotor time 20.50.51.0-0.81.00.9-0.80.80.70.8-0.80.20.6-0.6-0.6-0.7-0.7
Total resting periods, locomotor time 20.30.30.5-0.40.70.6-0.60.60.60.6-0.60.10.4-0.4-0.4-0.6-0.6
Rest time, locomotor task time 20.40.42.51.6-0.7-0.7-0.40.40.40.5-0.40.60.6-0.6-0.6-0.5-0.5
Distance moved, locomotor task time 20.91.01.6-1.01.31.2-0.80.80.70.8-0.81.21.1-1.1-1.1-1.0-1.0
Vertical activity count, locomotor time 20.91.02.4-1.51.21.2-0.90.90.70.8-0.80.80.8-0.8-0.8-0.9-1.1
Light reinforcement 10.20.30.60.3-0.1-0.2-0.60.50.60.5-0.30.60.7-0.7-0.7-0.7-0.7
Light reinforcement 20.20.30.70.3-0.1-0.00.7-0.7-0.6-0.70.7-0.8-0.50.50.50.60.4
Bone: marrow area0.20.41.00.9-1.0-1.00.6-0.60.0-0.50.4-0.9-0.50.50.5-0.1-0.0
Bone: maximum diameter0.40.72.00.2-1.4-1.40.8-0.7-0.1-0.70.6-1.1-0.80.80.80.20.3
Bone: maximum force1.42.33.00.5-1.3-1.31.7-1.7-1.4-1.71.7-1.5-1.61.61.61.61.7
Bone: maximum moment1.32.22.70.7-1.5-1.51.5-1.5-1.3-1.51.4-1.3-1.51.51.51.61.6
Mean time between licks in bursts0.30.51.30.40.1-0.2-0.40.50.20.9-1.10.80.7-0.7-0.7-0.6-1.1
Mean num. licks in bursts0.10.10.3-0.3-0.00.00.1-0.1-0.2-0.1-0.0-0.3-0.50.50.50.30.4
Cd content in liver0.20.20.6-0.40.10.1-0.50.50.80.4-0.30.30.4-0.4-0.4-0.7-0.7
Co content in liver0.60.73.0-1.71.61.70.1-0.00.30.2-0.4-0.4-0.30.30.3-0.6-0.9
Cu content in liver0.91.14.8-1.82.12.2-0.30.30.90.3-0.2-0.10.4-0.4-0.4-0.9-1.1
Fe content in liver1.41.73.3-0.8-0.10.01.4-1.4-0.5-1.41.3-1.8-1.61.61.61.51.5
K content in liver3.93.911.9-3.13.43.4-1.71.71.41.5-1.51.11.3-1.3-1.3-0.8-0.9
Mg content in liver2.82.84.6-1.82.12.1-1.81.81.71.7-1.91.31.5-1.5-1.5-1.1-1.3
Mn content in liver0.50.51.4-1.01.21.2-0.40.51.00.6-0.80.20.4-0.4-0.4-0.5-0.9
Na content in liver1.01.12.3-0.40.10.21.0-1.0-1.3-1.11.2-1.0-1.01.01.01.51.5
Rb content in liver0.91.13.3-1.81.81.80.6-0.5-0.5-0.50.2-1.1-0.70.70.70.90.5
Se content in liver0.10.10.3-0.20.30.4-0.0-0.00.6-0.10.3-0.00.3-0.3-0.30.00.1
Sr content in liver0.20.21.0-0.60.20.2-0.10.21.00.1-0.4-0.1-0.50.50.5-0.2-0.6
Zn content in liver0.50.52.9-1.31.71.60.2-0.2-0.5-0.10.2-0.10.1-0.1-0.10.30.1
Bone: minimum diameter0.91.82.6-0.2-1.4-1.41.4-1.5-0.8-1.51.5-1.6-1.51.51.50.91.0
Time in familiar zone, hab. session 10.00.00.30.5-0.1-0.10.1-0.1-0.1-0.20.30.10.0-0.0-0.0-0.10.0
Time in novel zone, hab. session 12.82.73.71.1-1.8-1.71.6-1.6-1.9-1.61.6-1.5-1.51.51.51.91.9
Total zone transitions, hab. session 14.25.811.6-0.9-0.4-0.4-3.43.33.12.8-2.82.72.5-2.5-2.5-1.8-1.7
Total locomotion distance, hab. session 17.310.318.7-0.90.10.1-4.34.33.73.9-3.93.73.5-3.5-3.5-2.5-2.6
Locomotion velocity, hab. session 111.416.227.1-1.30.60.6-5.25.24.74.9-5.04.54.2-4.2-4.2-3.5-3.7
Time in familiar zone, hab. session 20.30.40.80.6-0.2-0.3-0.60.6-0.20.7-0.60.90.8-0.8-0.8-0.3-0.2
Time in novel zone, hab. session 20.50.40.80.3-0.4-0.30.7-0.7-0.3-0.80.8-0.9-0.90.90.90.50.4
Total zone transitions, hab. session 21.21.53.20.6-1.8-1.8-1.71.61.11.2-1.01.51.1-1.1-1.1-0.3-0.2
Total locomotion distance, hab. session 25.77.512.60.7-1.1-1.1-3.63.53.13.2-3.13.23.0-3.0-3.0-2.3-2.5
Locomotion velocity, hab. session 26.38.514.20.5-0.9-0.9-3.83.73.43.4-3.33.43.1-3.1-3.1-2.6-2.7
Novel to familiar place preference ratio0.20.21.2-0.61.01.1-0.0-0.0-0.2-0.10.40.20.3-0.3-0.30.00.1
Novelty place preference0.10.20.9-0.30.80.90.1-0.2-0.2-0.20.50.20.1-0.1-0.10.10.1
Time in novel zone, NPP test0.20.20.6-0.10.40.50.4-0.5-0.7-0.50.7-0.1-0.20.20.20.40.5
Total zone transitions, NPP test0.91.23.2-0.7-0.6-0.7-1.81.71.41.3-1.21.11.0-1.0-1.0-0.4-0.4
Total locomotion distance, NPP test7.610.418.5-1.00.40.3-4.34.23.63.9-3.93.63.5-3.5-3.5-2.6-2.7
Locomotion velocity, NPP test7.410.518.5-1.10.70.6-4.34.23.83.9-3.93.63.5-3.5-3.5-2.7-2.8
Intraocular pressure0.10.21.00.8-0.00.10.2-0.10.50.00.00.20.2-0.2-0.2-0.9-1.0
Delta distance traveled before/after self-admin0.60.61.6-0.7-0.1-0.30.5-0.5-0.6-0.70.7-0.9-0.90.90.91.01.2
Delta ambulatory time before/after self-admin2.22.54.6-0.1-0.9-1.11.4-1.4-1.5-1.61.6-1.7-1.81.81.81.92.1
Parametrial fat weight0.61.23.61.6-1.8-1.90.4-0.4-0.6-0.70.6-0.6-0.90.90.91.01.2
Pavlov. Cond. lever latency0.30.41.3-0.40.50.40.9-0.8-1.1-0.60.6-0.8-0.40.40.40.60.2
Pavlov. Cond. magazine entry latency0.81.05.02.0-2.2-2.2-0.10.1-0.0-0.00.20.60.2-0.2-0.20.10.4
Pavlov. Cond. change in total contacts0.60.72.91.6-1.7-1.7-0.20.10.30.10.10.60.3-0.3-0.3-0.30.0
Pavlov. Cond. index score0.81.13.01.5-1.7-1.7-1.00.91.10.7-0.61.20.7-0.7-0.7-0.6-0.3
Pavlov. Cond. latency score0.70.91.71.2-1.3-1.3-1.01.01.20.8-0.71.20.7-0.7-0.7-0.7-0.4
Pavlov. Cond. lever contacts0.91.13.00.2-0.5-0.5-1.41.41.71.1-1.11.30.9-0.9-0.9-1.1-0.6
Pavlov. Cond. magazine entry number0.91.15.7-1.92.42.30.1-0.10.10.1-0.2-0.30.0-0.0-0.0-0.3-0.6
Pavlov. Cond. intertrial magazine entries2.12.53.50.9-1.4-1.41.8-1.8-1.2-1.71.6-1.9-1.81.81.81.41.4
Pavlov. Cond. lever-magazine prob. diff.0.81.02.81.4-1.7-1.6-1.00.91.00.6-0.51.10.7-0.7-0.7-0.6-0.2
Pavlov. Cond. response bias0.70.93.41.4-1.8-1.8-0.70.70.90.4-0.40.80.4-0.4-0.4-0.4-0.1
Pavlov. Cond. lever latency0.20.31.3-1.10.30.40.1-0.10.3-0.20.0-0.9-0.70.70.70.30.2
Pavlov. Cond. magazine entry latency0.10.20.40.7-0.2-0.30.1-0.10.00.10.00.50.5-0.5-0.5-0.6-0.4
Pavlov. Cond. change in total contacts0.10.10.4-0.20.50.40.1-0.1-0.00.1-0.00.40.4-0.4-0.4-0.6-0.5
Pavlov. Cond. index score0.10.20.40.5-0.2-0.30.0-0.0-0.10.2-0.00.60.6-0.6-0.6-0.5-0.3
Pavlov. Cond. latency score0.20.20.60.40.20.0-0.20.20.20.3-0.20.70.7-0.7-0.7-0.7-0.5
Pavlov. Cond. lever contacts0.40.51.91.4-0.8-0.9-0.20.2-0.10.4-0.21.00.8-0.8-0.8-0.5-0.4
Pavlov. Cond. magazine entry number0.40.51.1-0.90.70.80.2-0.2-0.5-0.50.4-0.7-0.70.70.71.10.8
Pavlov. Cond. intertrial magazine entries0.20.20.5-0.10.60.7-0.60.60.20.5-0.40.50.5-0.5-0.5-0.2-0.3
Pavlov. Cond. lever-magazine prob. diff.0.10.10.30.3-0.1-0.10.1-0.0-0.10.10.00.50.5-0.5-0.5-0.5-0.2
Pavlov. Cond. response bias0.30.41.71.3-1.0-1.1-0.10.1-0.10.2-0.10.80.7-0.7-0.7-0.5-0.3
Time in closed arm before self-admin0.10.10.4-0.60.40.3-0.30.3-0.10.2-0.10.10.3-0.3-0.3-0.20.0
Time in closed arm after self-admin0.40.41.01.0-0.7-0.9-0.20.2-0.00.4-0.40.40.6-0.6-0.6-0.6-0.9
Time in open arm before self-admin0.20.20.80.6-0.9-0.90.3-0.30.0-0.20.2-0.2-0.40.40.40.40.1
Time in open arm after self-admin0.20.20.60.3-0.2-0.30.3-0.4-0.0-0.50.4-0.4-0.70.70.70.70.5
Bone: periosteal estimation0.51.01.80.4-1.3-1.31.1-1.1-0.4-1.00.9-1.4-1.11.11.10.60.7
Bone: periosteal perimeter0.30.51.50.2-1.2-1.10.5-0.50.2-0.60.5-0.9-0.80.80.80.20.3
Bone: post-yield work1.31.82.40.7-1.4-1.31.6-1.5-1.2-1.41.4-1.3-1.31.31.31.41.5
Progressive ratio test 1 active lever presses1.31.49.3-3.02.02.0-0.30.30.50.3-0.2-0.00.6-0.6-0.6-0.6-0.3
Progressive ratio test 1 breakpoint1.41.47.7-2.81.91.9-0.50.50.70.5-0.40.20.8-0.8-0.8-0.8-0.6
Progressive ratio test 1 inactive lever presses0.40.41.4-1.21.11.1-0.40.40.50.5-0.50.40.5-0.5-0.5-0.5-0.3
Progressive ratio test 2 active lever presses3.03.26.0-2.51.91.9-1.81.71.91.7-1.61.41.8-1.8-1.8-1.8-1.6
Progressive ratio test 2 breakpoint3.33.76.0-2.51.91.9-1.91.82.01.8-1.71.62.0-2.0-2.0-2.0-1.8
Progressive ratio test 2 inactive lever presses0.70.92.9-1.71.11.2-0.90.91.20.8-0.90.50.6-0.6-0.6-0.7-0.2
Incentive Sensitization - Responses2.72.84.7-2.21.41.3-1.81.81.81.8-1.81.41.6-1.6-1.6-1.6-1.6
Incentive Sensitization - Breakpoint2.52.54.2-2.01.31.2-1.71.71.71.7-1.71.31.5-1.5-1.5-1.6-1.5
Sum of active levers in priming session hrs 5-61.91.93.40.7-0.9-1.0-1.51.51.41.4-1.31.91.6-1.6-1.6-1.6-0.8
Progressive ratio0.10.10.7-0.10.80.70.2-0.2-0.2-0.30.4-0.0-0.30.30.30.20.4
Food seeking constrained by brief footshock0.91.14.6-2.11.71.90.7-0.7-0.5-0.70.7-0.8-0.70.70.70.50.6
Seeking ratio, punishment vs. effort0.20.20.5-0.7-0.00.30.4-0.4-0.3-0.50.5-0.6-0.40.40.40.50.3
Retroperitoneal fat weight0.72.24.5-2.11.71.6-1.01.11.61.3-1.51.01.4-1.4-1.4-1.5-1.6
Reaction time number correct0.20.31.90.6-1.2-1.40.00.00.40.1-0.4-0.1-0.30.30.30.1-0.2
Reaction time mean minus median0.10.20.70.20.50.30.3-0.3-0.7-0.20.1-0.1-0.30.30.30.80.7
Reaction time mean minus median AUC0.10.10.40.40.30.10.1-0.0-0.60.0-0.20.2-0.10.10.10.60.4
Reaction time num false alarms0.50.71.50.5-0.5-0.60.5-0.6-1.2-0.91.0-0.6-0.80.80.81.10.9
Reaction time num false alarms AUC0.20.30.80.9-0.6-0.70.2-0.3-0.9-0.50.7-0.3-0.50.50.50.70.4
Reaction time trials correct on left0.20.31.90.6-1.2-1.40.00.00.40.1-0.4-0.1-0.30.30.30.1-0.2
Reaction time trials on left0.30.42.30.7-1.3-1.50.1-0.00.30.0-0.3-0.1-0.30.30.30.1-0.1
Reaction time mean0.10.10.20.4-0.3-0.4-0.30.20.50.2-0.10.30.4-0.4-0.4-0.4-0.3
Reaction time mean AUC0.10.10.2-0.10.10.0-0.30.20.50.2-0.00.30.4-0.4-0.4-0.4-0.3
Median of all reaction times0.20.20.60.0-0.2-0.3-0.40.40.80.3-0.10.40.6-0.6-0.6-0.8-0.5
Reaction time omissions2.83.812.83.6-2.8-3.21.6-1.6-2.2-1.31.3-0.7-1.11.11.11.61.5
Reaction time false alarm rate0.10.20.80.50.10.10.1-0.2-0.9-0.40.7-0.2-0.30.30.30.50.5
Reaction time premature initiation rate2.53.45.10.70.00.0-1.92.01.82.1-2.32.12.1-2.1-2.1-2.1-2.1
Reaction time premature initiations2.13.05.30.6-0.2-0.4-1.81.91.92.0-2.31.91.8-1.8-1.8-1.9-2.1
Std. dev. reaction times0.10.10.40.6-0.2-0.3-0.00.0-0.5-0.00.00.2-0.00.00.00.50.6
Reaction time trials completed0.30.42.30.7-1.3-1.50.1-0.00.30.0-0.3-0.1-0.30.30.30.1-0.1
Reaction time trials AUC0.20.31.80.6-1.1-1.3-0.20.20.60.2-0.50.1-0.10.10.1-0.2-0.4
Run reversals in cocaine runway, females4.44.35.5-1.41.51.6-2.32.32.42.3-2.31.92.2-2.2-2.2-2.1-2.0
Run reversals in cocaine runway, males1.51.51.81.0-1.3-1.01.3-1.3-1.2-1.31.3-1.0-1.21.21.21.21.0
Latency to leave start box in cocaine runway0.30.31.81.1-1.3-1.30.0-0.0-0.10.1-0.00.30.1-0.1-0.1-0.10.1
Latency to leave start box in cocaine runway, F0.40.41.91.4-1.3-1.2-0.20.20.00.2-0.20.60.4-0.4-0.4-0.4-0.1
Latency to leave start box in cocaine runway, M0.20.11.5-1.20.30.1-0.20.20.30.3-0.4-0.20.1-0.1-0.1-0.1-0.1
Std. dev. time between licks in bursts0.50.62.61.6-0.9-0.9-0.30.4-0.30.7-0.71.00.7-0.7-0.7-0.1-0.5
Total sessions with >9 infusions0.50.52.0-1.41.01.0-0.40.40.70.5-0.30.10.7-0.7-0.7-0.8-0.3
Short access day 1 total inactive lever presses0.20.20.8-0.1-0.6-0.70.3-0.3-0.0-0.30.3-0.4-0.40.40.40.30.9
Short access day 10 total inactive lever presses0.60.66.52.6-0.9-0.80.3-0.3-0.2-0.20.20.5-0.20.20.2-0.0-0.2
Short access day 1 total infusions1.61.72.8-0.90.90.8-1.21.21.51.3-1.11.21.7-1.7-1.7-1.6-0.8
Short access day 10 total infusions0.50.64.0-2.01.11.20.4-0.4-0.1-0.40.5-0.8-0.30.30.30.20.0
Short access total infusions0.60.71.8-1.40.90.9-0.60.60.70.6-0.50.50.9-0.9-0.9-1.0-0.6
Short access day 1 locomotion0.80.81.6-1.31.21.2-0.70.61.00.7-0.60.70.9-0.9-0.9-0.9-0.5
Short access day 10 total locomotion0.40.41.2-1.10.80.80.3-0.20.0-0.30.1-0.9-0.80.80.80.50.7
Short access total locomotion0.70.74.9-2.21.41.3-0.10.10.20.0-0.2-0.5-0.30.30.30.10.6
One hour access (0.3 mA shock)2.12.58.6-2.92.02.1-1.51.51.81.4-1.50.71.0-1.0-1.0-1.4-0.3
Compulsive drug intake1.61.63.11.0-0.7-0.71.1-1.1-1.1-1.21.0-1.0-1.81.81.81.41.6
One hour access (shock baseline)2.93.49.0-3.02.12.1-1.71.71.91.7-1.61.21.7-1.7-1.7-1.8-0.9
Social response proportion0.50.51.2-0.90.10.1-1.01.00.91.0-1.10.40.6-0.6-0.6-0.6-0.1
Social responses3.34.27.7-0.60.50.5-2.42.52.62.5-2.82.12.1-2.1-2.1-2.0-1.9
Social time0.30.41.0-0.5-0.4-0.3-0.80.81.00.6-0.60.50.5-0.5-0.5-0.7-0.7
Soleus weight0.41.23.10.9-1.8-1.70.8-0.8-1.6-0.80.9-0.7-0.80.80.81.21.2
Bone: stiffness1.62.64.4-0.9-1.1-1.11.4-1.3-1.2-1.51.3-2.0-1.91.91.92.12.1
Tibialis anterior weight0.72.33.91.4-1.3-1.32.0-2.0-1.6-1.81.7-1.4-1.51.51.51.11.0
Time to tail flick, vehicle, before self-admin1.11.14.0-0.2-2.0-1.80.8-0.8-0.8-0.80.7-0.9-0.80.80.80.91.2
Time to tail flick, vehicle, after self-admin0.20.21.51.2-0.8-0.70.1-0.00.0-0.10.00.1-0.20.20.20.3-0.1
Time to tail flick, test, before self-admin0.80.81.3-0.3-0.8-0.90.6-0.6-1.0-0.80.7-1.2-0.90.90.91.01.1
Time to tail flick, test, after self-admin0.20.20.60.1-0.4-0.7-0.60.60.20.6-0.80.30.3-0.3-0.3-0.4-0.5
Delta time to tail flick, vehicle, before/after SA0.40.43.01.70.30.1-0.30.30.40.3-0.30.70.4-0.4-0.4-0.4-1.0
Delta time to tail flick, test, before/after SA0.30.30.8-0.10.80.7-0.50.50.40.5-0.60.60.4-0.4-0.4-0.5-0.9
Tibia length0.92.518.7-4.32.42.50.4-0.40.8-0.40.3-1.1-0.30.30.3-0.6-0.6
Ambulatory time before self-admin2.22.22.9-0.51.11.3-1.61.61.21.6-1.61.51.7-1.7-1.7-1.6-1.6
Ambulatory time after self-admin0.10.10.3-0.6-0.1-0.1-0.20.30.30.1-0.1-0.1-0.10.10.10.20.6
Bone: tissue strength0.40.40.9-0.5-0.5-0.50.2-0.2-0.2-0.40.3-0.7-0.80.80.80.80.9
Total heroin consumption0.91.12.91.7-1.4-1.4-0.90.80.90.8-0.71.10.9-0.9-0.9-0.9-0.3
Bone: trabecular number0.10.10.3-0.4-0.1-0.1-0.00.00.4-0.1-0.2-0.4-0.60.60.60.20.4
Bone: trabecular spacing0.40.51.10.70.50.5-0.30.30.10.5-0.11.11.0-1.0-1.0-0.9-0.9
Bone: trabecular thickness0.70.81.5-0.5-0.2-0.20.9-0.9-0.7-1.00.8-1.1-1.21.21.20.91.0
Bone: trabecular tissue density0.10.20.8-0.90.60.6-0.0-0.10.1-0.30.5-0.1-0.20.20.20.30.4
Water consumed over 24 hours1.41.73.1-0.3-0.7-0.51.6-1.6-1.3-1.41.3-1.8-1.51.51.51.01.2
Number of responses in last shaping day0.40.42.3-1.51.01.0-0.50.50.80.4-0.50.10.2-0.2-0.2-0.30.3