Hub : Genes

Mrpl12

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Mrpl12	0.36	0.16	2.8e-11	0.1	0.11	0.12	0.09	2.4e-11	1.3e-12	2.9e-13	1.7e-10
2	Liver	gene expression	Mrpl12	0.04	0.03	1.9e-05	0.02	0.04	0.04	0.03	3.6e-03	3.3e-05	8.3e-05	1.5e-04
3	BLA	intron excision ratio	chr10_106257047_106257531	0.06	0.05	9.3e-03	0.02	0.02	-0	0.01	2.5e-02	4.1e-02	4.8e-01	7.1e-02
4	BLA	intron excision ratio	chr10_106257717_106257946	0.06	0.05	7.6e-03	0.03	0.01	0	0.01	1.6e-02	5.0e-02	2.5e-01	5.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.2	0.4	0.7	-0.2	-0.3	0.8	-0.8
Area under the delay curve	1.4	1.6	2.4	1.6	1.5	-1.0	1.0
BMI with tail	0.3	1.2	1.7	-0.9	-0.8	1.3	-1.3
BMI without tail	1.7	5.1	6.2	-1.7	-2.3	2.5	-2.5
Body weight	1.8	7.8	12.5	-3.4	-3.5	1.9	-1.9
Weight adjusted by age	1.5	2.3	3.7	-1.5	-1.9	1.3	-1.3
Bone surface	0.2	0.3	0.7	-0.8	-0.7	0.0	-0.0
Bone volume	0.2	0.3	0.4	-0.6	-0.7	0.4	-0.4
Breakpoint value in progressive ratio session	0.5	0.6	1.2	-0.9	-1.1	-0.3	0.3
Number of licking bursts	0.2	0.3	0.5	-0.1	-0.1	0.7	-0.7
Context. condit. distance diff. score	2.2	2.7	4.9	0.9	0.2	2.2	-2.2
Locomotion velocity, session 1	2.3	2.4	4.3	0.5	1.0	-2.1	2.1
Locomotion distance, session 1	2.0	2.6	5.1	2.3	2.3	0.1	-0.1
Locomotion velocity, session 2	2.8	3.2	4.5	1.6	2.1	-1.7	1.7
Locomotion distance, session 2	0.8	1.1	1.9	1.4	1.1	0.8	-0.8
Locomotion velocity, session 3	1.3	1.5	2.1	0.7	1.1	-1.4	1.4
Locomotion distance, session 3	2.0	2.2	3.7	1.6	1.9	-1.1	1.1
Stereotopy head waving bouts, day 3	0.6	0.8	1.4	0.1	0.4	-1.2	1.2
Stereotopy head waving duration, day 3	0.2	0.3	0.3	0.3	0.6	-0.5	0.5
Locomotion velocity, session 7	0.4	0.5	1.0	0.9	1.0	-0.1	0.1
Locomotion distance, session 7	3.1	4.0	8.2	2.9	2.6	0.8	-0.8
Stereotopy head waving bouts, day 7	0.1	0.2	0.3	-0.5	-0.6	0.2	-0.2
Stereotopy head waving duration, day 7	0.3	0.3	0.7	-0.8	-0.7	0.2	-0.2
Locomotion velocity, session 8	1.3	1.6	2.8	1.7	1.3	1.0	-1.0
Locomotion distance, session 8	3.8	5.5	8.5	2.0	1.0	2.9	-2.9
Degree of sensitization distance	1.2	1.3	2.4	0.3	-0.2	1.6	-1.6
Degree of sensitization stereotypy	0.2	0.3	0.4	-0.3	-0.5	0.6	-0.6
Conditioned locomotion	2.7	3.1	4.3	-1.1	-1.6	2.1	-2.1
Cocaine response after cond. corrected	0.4	0.5	0.9	-0.1	0.0	-1.0	1.0
Cocaine response after cond. not corrected	0.6	0.7	1.3	0.4	0.6	-1.1	1.1
Cocaine response before conditioning	0.5	0.6	1.3	1.0	1.1	0.1	-0.1
Saline control response	1.7	2.3	3.1	-1.5	-1.8	1.4	-1.4
Bone: connectivity density	0.3	0.4	0.7	0.5	0.4	0.8	-0.8
Bone: cortical apparent density	1.7	2.3	3.7	1.5	1.9	-1.3	1.3
Bone: cortical area	3.7	5.7	10.9	-3.2	-3.3	0.9	-0.9
Bone: cortical porosity	3.1	3.3	3.8	-1.9	-1.6	-1.9	1.9
Bone: cortical porosity	2.6	2.9	4.0	-2.0	-1.8	-1.4	1.4
Bone: cortical thickness	3.6	6.0	12.2	-3.5	-3.4	0.3	-0.3
Bone: cortical thickness	0.9	1.1	2.4	-1.5	-1.4	0.1	-0.1
Bone: cortical tissue density	1.9	2.5	4.0	1.6	2.0	-1.4	1.4
Condit. Reinf. active minus inactive responses	1.4	1.6	2.2	-1.0	-1.5	1.2	-1.2
Condit. Reinf. active-inactive response ratio	0.6	0.7	0.9	-0.7	-0.9	0.8	-0.8
Condit. Reinf. active responses	2.5	3.1	4.3	-1.5	-2.1	1.7	-1.7
Condit. Reinf. inactive responses	0.5	0.6	1.0	-0.6	-1.0	0.8	-0.8
Incentive salience index mean	1.3	1.6	1.8	-1.0	-1.3	1.3	-1.3
Condit. Reinf. lever presses	0.3	0.4	0.8	0.3	0.2	0.9	-0.9
Condit. Reinf. active minus inactive responses	0.2	0.3	0.3	-0.4	-0.6	0.5	-0.5
Condit. Reinf. active-inactive response ratio	1.1	1.3	2.8	-1.6	-1.7	0.1	-0.1
Condit. Reinf. active responses	0.1	0.2	0.2	0.5	0.2	0.5	-0.5
Condit. Reinf. inactive responses	0.8	1.0	2.3	1.5	1.4	0.1	-0.1
Condit. Reinf. lever presses	0.5	0.7	1.2	0.7	0.1	1.1	-1.1
Condit. Reinf. lever reinforcers received	0.3	0.4	0.5	0.7	0.3	0.7	-0.7
Conditioned reinforcement - actives	0.0	0.1	0.1	0.1	0.3	0.2	-0.2
Conditioned reinforcement - inactives	0.5	0.8	1.5	-1.2	-0.8	0.7	-0.7
Conditioned locomotion	0.0	0.1	0.2	-0.4	-0.0	0.2	-0.2
Patch foraging indifference point 0 sec	0.0	0.1	0.1	-0.3	-0.3	0.2	-0.2
Patch foraging indifference point AUC	0.1	0.1	0.2	0.2	0.1	0.4	-0.4
Delay disc. indifference point, 0s delay	0.0	0.0	0.1	0.2	0.1	0.1	-0.1
Delay disc. indifference point, 16s delay	2.0	2.2	4.8	2.2	1.9	0.4	-0.4
Delay disc. indifference point, 2s delay	0.3	0.4	0.5	0.4	0.6	-0.7	0.7
Delay disc. indifference point, 24s delay	3.8	4.3	5.4	1.4	2.1	-2.3	2.3
Delay disc. indifference point, 4s delay	0.7	0.7	1.0	0.8	0.5	-1.0	1.0
Delay disc. indifference point, 8s delay	1.0	1.2	1.9	0.7	0.8	-1.4	1.4
Indifference point function ln k	0.4	0.7	1.4	1.2	1.2	-0.3	0.3
Indifference point function log k	0.4	0.7	1.4	1.2	1.2	-0.3	0.3
Patch foraging total patch changes 0 sec	0.0	0.1	0.1	-0.1	-0.2	0.4	-0.4
Patch foraging total patch changes 12 sec	0.1	0.2	0.2	-0.3	-0.4	-0.5	0.5
Patch foraging total patch changes 18 sec	0.7	1.1	1.4	1.2	0.6	1.1	-1.1
Patch foraging total patch changes 24 sec	0.5	0.9	1.1	-0.9	-0.9	1.1	-1.1
Patch foraging total patch changes 6 sec	0.4	0.6	1.3	-1.1	-1.0	-0.1	0.1
Patch foraging time to switch 0 sec	0.3	0.6	0.8	0.6	0.7	-0.9	0.9
Patch foraging water rate 0 sec	1.2	2.5	3.7	-0.9	-1.4	1.9	-1.9
Patch foraging water rate 12 sec	0.5	1.1	2.0	0.6	0.1	1.4	-1.4
Patch foraging water rate 18 sec	1.3	2.0	3.9	0.0	-0.3	2.0	-2.0
Patch foraging water rate 24 sec	3.0	4.2	8.2	0.1	-0.7	2.9	-2.9
Patch foraging water rate 6 sec	0.4	0.6	1.2	0.5	0.0	1.1	-1.1
Seeking ratio, delayed vs. immediate footshock	0.8	1.0	1.3	-1.1	-1.2	0.9	-0.9
Distance traveled before self-admin	0.6	0.8	1.8	-1.1	-1.3	0.2	-0.2
Distance traveled after self-admin	0.9	1.2	2.1	-0.4	-0.6	1.4	-1.4
Extensor digitorum longus weight	0.6	2.4	4.1	1.2	0.4	2.0	-2.0
Bone: elastic displacement	1.0	1.1	2.2	-1.5	-1.5	0.1	-0.1
Bone: elastic work	5.6	7.3	14.5	-3.8	-3.8	-0.4	0.4
Bone: endosteal estimation	0.3	0.6	0.9	1.0	0.5	0.8	-0.8
Bone: endosteal perimeter	0.4	0.9	1.7	-1.3	-1.3	0.2	-0.2
Epididymis fat weight	1.0	3.3	4.4	-1.3	-1.7	2.1	-2.1
Delta time in closed arm before/after self-admin	0.4	0.4	0.6	0.5	0.4	0.7	-0.7
Delta time in open arm before/after self-admin	0.1	0.1	0.1	0.2	0.2	0.2	-0.2
Diff in mean of infusions in LGA sessions	0.2	0.3	0.7	-0.8	-0.6	-0.3	0.3
Delay discount exponential model param	2.1	2.3	2.7	-1.6	-1.7	1.4	-1.4
Extinction: sum of active levers before priming	0.2	0.2	0.3	0.3	0.5	-0.5	0.5
Active lever presses in extinction session 6	1.2	1.2	2.3	-0.4	-0.2	-1.5	1.5
Bone: final force	3.6	5.7	10.4	-2.7	-3.2	1.6	-1.6
Bone: final moment	4.1	6.6	12.8	-3.1	-3.6	1.4	-1.4
Food consumed during 24 hour testing period	0.2	0.3	0.5	-0.5	-0.7	0.4	-0.4
Glucose	8.4	13.3	25.0	0.7	1.6	-5.0	5.0
Heart weight	0.3	0.5	1.4	-0.9	-1.2	-0.0	0.0
Delay discount hyperbolic model param	1.9	2.2	2.3	-1.5	-1.5	1.4	-1.4
Intermittent access intake day 1-15 change	0.3	0.7	1.2	-1.0	-1.1	-0.5	0.5
Intermittent access intake escalation	0.3	0.6	1.0	-1.0	-1.0	-0.4	0.4
Intermittent access intake escalation 2	1.2	1.3	3.1	-1.4	-1.8	-0.4	0.4
Intermitt. access day 1 inactive lever presses	0.6	2.4	3.6	-0.6	-1.4	1.9	-1.9
Intermitt. access day 15 inactive lever presses	1.0	2.0	3.8	-0.3	-0.6	2.0	-2.0
Intermitt. access escalation Index	0.4	0.6	1.1	-0.2	-0.3	1.1	-1.1
Intermittent access day 1 total infusions	0.1	0.1	0.4	-0.7	-0.2	0.2	-0.2
Intermittent access day 15 total infusions	0.4	0.6	1.4	-1.2	-0.8	0.2	-0.2
Intermittent access terminal intake (last 3 days)	0.7	0.9	2.1	-1.4	-1.1	0.3	-0.3
Intermittent access total infusions	0.3	0.4	1.1	-1.1	-0.5	0.2	-0.2
Intermittent access day 1 locomotion	0.1	0.1	0.3	-0.5	-0.1	0.1	-0.1
Intermittent access day 15 total locomotion	0.4	0.8	2.2	-1.5	-0.9	-0.2	0.2
Intermittent access total locomotion	0.4	0.4	1.4	-1.2	-0.6	0.1	-0.1
Intermittent access standard deviation	0.6	1.2	2.5	-0.2	-0.1	-1.6	1.6
Left kidney weight	0.2	1.1	1.4	-1.2	-0.7	-1.1	1.1
Right kidney weight	0.2	0.7	1.1	-1.1	-0.5	-0.9	0.9
Cocaine induced anxiety	2.0	2.8	5.7	-2.4	-1.8	-1.1	1.1
Post-drug Anxiety	2.2	2.4	3.6	-1.3	-0.7	-1.9	1.9
Baseline Anxiety	1.5	1.8	2.3	1.5	1.5	-1.2	1.2
Tail length	2.3	9.0	15.2	-3.4	-3.9	2.2	-2.2
Length with tail	1.6	7.1	14.6	-3.8	-3.7	0.2	-0.2
Length without tail	1.1	3.5	6.7	-2.6	-1.8	-1.5	1.5
Times rat made contact with spout	1.5	1.7	2.9	-1.7	-1.6	-0.9	0.9
Lifetime Intake	0.2	0.2	0.8	-0.9	-0.1	0.0	-0.0
Liver weight, left	0.6	1.0	1.8	-0.0	0.5	-1.3	1.3
Liver weight, right	2.0	3.6	5.0	-2.2	-2.2	1.5	-1.5
Locomotor activity	0.5	0.8	1.2	1.1	1.0	-0.7	0.7
Locomotor testing distance	0.8	1.5	3.3	1.8	1.6	-0.0	0.0
Locomotor testing rearing	0.4	0.8	1.6	1.3	1.1	0.4	-0.4
Locomotion in novel chamber	0.3	0.4	0.5	0.4	0.7	0.7	-0.7
Locomotion in novel chamber post-restriction	1.6	2.7	4.4	-1.9	-2.1	1.1	-1.1
Fecal boli incidents, locomotor time 1	0.1	0.2	0.6	0.5	0.7	-0.1	0.1
Change in fecal boli incidents, locomotor task	2.0	2.0	3.8	0.4	0.6	-1.9	1.9
Time >=10cm from walls, locomotor time 1	0.6	0.7	1.3	0.1	-0.2	1.1	-1.1
Bouts of movement, locomotor time 1	1.1	1.3	1.6	1.0	1.3	-1.1	1.1
Total resting periods, locomotor time 1	1.6	1.8	2.2	1.0	1.3	-1.5	1.5
Rest time, locomotor task time 1	0.8	1.0	1.9	-0.1	0.1	-1.4	1.4
Distance moved, locomotor task time 1	0.3	0.4	0.8	-0.1	-0.5	0.9	-0.9
Vertical activity count, locomotor time 1	0.6	1.5	2.8	-0.4	-0.6	1.7	-1.7
Time >=10cm from walls, locomotor time 2	0.0	0.1	0.1	-0.3	-0.3	-0.2	0.2
Bouts of movement, locomotor time 2	0.4	0.7	1.5	0.6	1.2	-0.6	0.6
Total resting periods, locomotor time 2	0.2	0.4	1.2	0.5	1.1	-0.2	0.2
Rest time, locomotor task time 2	0.1	0.2	0.3	-0.4	0.1	-0.5	0.5
Distance moved, locomotor task time 2	0.1	0.1	0.2	0.4	-0.0	0.4	-0.4
Vertical activity count, locomotor time 2	0.4	0.6	1.0	0.5	0.2	1.0	-1.0
Light reinforcement 1	1.2	3.0	5.9	-0.3	-0.6	2.4	-2.4
Light reinforcement 2	1.9	2.9	3.9	-1.3	-1.4	2.0	-2.0
Bone: marrow area	0.3	0.7	1.0	1.0	0.6	0.8	-0.8
Bone: maximum diameter	1.0	1.9	3.7	-1.9	-1.9	0.4	-0.4
Bone: maximum force	3.1	5.5	10.1	-2.5	-3.2	1.7	-1.7
Bone: maximum moment	3.5	6.1	12.1	-2.8	-3.5	1.4	-1.4
Mean time between licks in bursts	0.5	1.2	2.3	1.4	1.5	-0.6	0.6
Mean num. licks in bursts	0.4	0.6	0.7	-0.8	-0.8	-0.8	0.8
Cd content in liver	1.3	1.5	3.1	1.8	1.2	0.8	-0.8
Co content in liver	0.1	0.1	0.2	-0.4	-0.3	-0.2	0.2
Cu content in liver	1.4	1.7	2.8	-1.7	-1.5	-0.9	0.9
Fe content in liver	0.4	0.5	0.9	1.0	0.9	0.1	-0.1
K content in liver	2.0	2.0	3.5	-0.6	-0.7	1.9	-1.9
Mg content in liver	2.3	2.3	4.4	0.6	0.3	2.1	-2.1
Mn content in liver	0.1	0.1	0.2	-0.4	-0.3	0.2	-0.2
Na content in liver	0.3	0.4	0.7	0.0	0.3	0.8	-0.8
Rb content in liver	1.6	1.8	3.3	-0.2	-0.8	1.8	-1.8
Se content in liver	0.3	0.4	0.6	-0.3	-0.4	0.8	-0.8
Sr content in liver	1.5	1.3	2.5	-0.5	-0.1	-1.6	1.6
Zn content in liver	1.1	1.2	1.4	-1.0	-1.2	1.1	-1.1
Bone: minimum diameter	2.2	4.0	8.0	-2.8	-2.8	0.5	-0.5
Time in familiar zone, hab. session 1	0.2	0.2	0.4	0.0	-0.0	-0.6	0.6
Time in novel zone, hab. session 1	0.2	0.2	0.4	0.2	0.1	0.6	-0.6
Total zone transitions, hab. session 1	0.5	0.6	1.5	1.2	0.9	0.3	-0.3
Total locomotion distance, hab. session 1	0.4	0.6	1.1	0.5	0.2	1.0	-1.0
Locomotion velocity, hab. session 1	0.5	0.7	1.3	0.4	0.2	1.2	-1.2
Time in familiar zone, hab. session 2	0.4	0.4	0.8	0.9	0.8	0.2	-0.2
Time in novel zone, hab. session 2	0.0	0.0	0.0	-0.0	0.0	-0.1	0.1
Total zone transitions, hab. session 2	1.9	2.4	3.1	1.8	1.2	1.6	-1.6
Total locomotion distance, hab. session 2	2.1	2.8	5.1	0.9	0.3	2.3	-2.3
Locomotion velocity, hab. session 2	2.1	2.8	5.4	0.6	0.0	2.3	-2.3
Novel to familiar place preference ratio	2.1	2.3	4.4	-2.1	-2.1	-0.4	0.4
Novelty place preference	2.1	2.3	4.3	-2.1	-2.1	-0.5	0.5
Time in novel zone, NPP test	1.5	1.7	3.3	-1.8	-1.8	-0.3	0.3
Total zone transitions, NPP test	2.6	3.7	4.3	2.1	1.5	2.0	-2.0
Total locomotion distance, NPP test	3.1	4.2	6.9	1.5	0.9	2.6	-2.6
Locomotion velocity, NPP test	2.2	3.0	5.4	1.1	0.5	2.3	-2.3
Intraocular pressure	0.2	0.3	0.5	0.0	-0.7	0.6	-0.6
Delta distance traveled before/after self-admin	0.6	0.6	0.7	0.7	0.8	0.8	-0.8
Delta ambulatory time before/after self-admin	0.8	1.0	2.1	1.3	1.5	0.4	-0.4
Parametrial fat weight	0.4	0.9	1.0	-0.9	-0.9	1.0	-1.0
Pavlov. Cond. lever latency	2.2	2.8	5.7	2.4	1.8	1.0	-1.0
Pavlov. Cond. magazine entry latency	2.1	2.7	5.2	-2.3	-2.2	-0.6	0.6
Pavlov. Cond. change in total contacts	1.7	1.8	2.1	-1.4	-1.0	-1.5	1.5
Pavlov. Cond. index score	2.7	3.4	7.3	-2.7	-2.5	-0.1	0.1
Pavlov. Cond. latency score	2.7	3.4	7.4	-2.7	-2.4	-0.5	0.5
Pavlov. Cond. lever contacts	1.1	1.4	3.1	-1.8	-1.4	-0.4	0.4
Pavlov. Cond. magazine entry number	3.1	3.9	6.7	2.6	2.4	1.3	-1.3
Pavlov. Cond. intertrial magazine entries	0.8	1.0	1.9	0.4	0.0	1.4	-1.4
Pavlov. Cond. lever-magazine prob. diff.	2.6	3.2	6.8	-2.6	-2.4	-0.2	0.2
Pavlov. Cond. response bias	2.4	3.0	5.6	-2.4	-2.1	-1.0	1.0
Pavlov. Cond. lever latency	1.4	1.8	3.5	-0.5	0.3	-1.9	1.9
Pavlov. Cond. magazine entry latency	2.2	2.7	6.1	2.5	1.9	0.6	-0.6
Pavlov. Cond. change in total contacts	0.9	1.4	2.6	1.6	1.0	1.0	-1.0
Pavlov. Cond. index score	0.9	1.2	2.3	1.5	0.8	1.0	-1.0
Pavlov. Cond. latency score	1.0	1.4	2.3	1.5	0.9	1.1	-1.1
Pavlov. Cond. lever contacts	1.3	1.7	3.3	0.7	-0.1	1.8	-1.8
Pavlov. Cond. magazine entry number	1.6	2.0	4.5	-2.1	-1.6	-0.6	0.6
Pavlov. Cond. intertrial magazine entries	0.8	1.3	1.7	-1.2	-1.3	1.0	-1.0
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.3	2.8	1.7	1.0	0.8	-0.8
Pavlov. Cond. response bias	0.9	1.3	1.8	1.4	0.6	1.2	-1.2
Time in closed arm before self-admin	1.0	1.3	2.6	-0.3	0.2	-1.6	1.6
Time in closed arm after self-admin	1.5	1.6	3.1	-0.1	0.4	-1.8	1.8
Time in open arm before self-admin	0.6	0.6	1.2	0.3	0.0	1.1	-1.1
Time in open arm after self-admin	0.6	0.6	1.0	0.7	0.3	1.0	-1.0
Bone: periosteal estimation	0.9	1.9	3.4	-1.6	-1.9	0.9	-0.9
Bone: periosteal perimeter	2.9	5.0	9.8	-3.1	-3.1	-0.5	0.5
Bone: post-yield work	0.2	0.3	0.6	0.8	0.4	0.5	-0.5
Progressive ratio test 1 active lever presses	0.3	0.3	0.7	-0.9	-0.5	0.3	-0.3
Progressive ratio test 1 breakpoint	0.3	0.4	0.9	-1.0	-0.6	0.3	-0.3
Progressive ratio test 1 inactive lever presses	2.3	3.4	5.1	-1.0	-1.5	2.3	-2.3
Progressive ratio test 2 active lever presses	0.2	0.2	0.8	-0.9	-0.4	-0.0	0.0
Progressive ratio test 2 breakpoint	0.2	0.2	0.8	-0.9	-0.4	-0.0	0.0
Progressive ratio test 2 inactive lever presses	0.3	0.5	1.5	-1.2	-0.7	0.0	-0.0
Incentive Sensitization - Responses	0.1	0.1	0.4	-0.7	-0.4	0.1	-0.1
Incentive Sensitization - Breakpoint	0.1	0.1	0.4	-0.6	-0.3	-0.0	0.0
Sum of active levers in priming session hrs 5-6	0.2	0.1	0.6	-0.1	-0.8	-0.0	0.0
Progressive ratio	0.4	0.6	1.1	1.0	1.0	-0.4	0.4
Food seeking constrained by brief footshock	0.6	0.8	1.5	-0.3	-0.0	-1.2	1.2
Seeking ratio, punishment vs. effort	0.0	0.0	0.1	-0.3	-0.3	0.1	-0.1
Retroperitoneal fat weight	2.2	9.3	9.8	-2.8	-3.1	3.1	-3.1
Reaction time number correct	4.4	8.4	13.3	2.3	1.2	3.6	-3.6
Reaction time mean minus median	0.2	0.6	0.8	-0.8	-0.1	-0.9	0.9
Reaction time mean minus median AUC	0.0	0.1	0.4	-0.6	-0.2	-0.1	0.1
Reaction time num false alarms	0.2	0.2	0.3	0.5	0.5	-0.5	0.5
Reaction time num false alarms AUC	0.3	0.4	0.8	0.8	0.9	-0.3	0.3
Reaction time trials correct on left	4.4	8.4	13.3	2.3	1.2	3.6	-3.6
Reaction time trials on left	4.6	8.6	13.8	2.3	1.2	3.7	-3.7
Reaction time mean	0.2	0.3	0.4	-0.3	-0.4	0.6	-0.6
Reaction time mean AUC	0.3	0.5	1.0	-0.0	-0.1	1.0	-1.0
Median of all reaction times	0.4	0.5	1.0	-0.0	-0.3	1.0	-1.0
Reaction time omissions	0.3	0.5	0.9	-0.2	-0.3	1.0	-1.0
Reaction time false alarm rate	1.7	2.3	4.6	-0.4	0.2	-2.1	2.1
Reaction time premature initiation rate	1.3	1.8	2.0	1.1	1.4	-1.4	1.4
Reaction time premature initiations	1.3	2.3	4.7	2.2	1.9	0.7	-0.7
Std. dev. reaction times	0.1	0.2	0.4	0.5	0.7	-0.1	0.1
Reaction time trials completed	4.6	8.6	13.8	2.3	1.2	3.7	-3.7
Reaction time trials AUC	4.6	8.8	14.2	2.3	1.2	3.8	-3.8
Run reversals in cocaine runway, females	1.0	1.0	2.1	1.4	1.4	0.1	-0.1
Run reversals in cocaine runway, males	1.4	1.4	2.9	-1.7	-1.7	-0.1	0.1
Latency to leave start box in cocaine runway	0.3	0.3	0.6	0.8	0.8	0.1	-0.1
Latency to leave start box in cocaine runway, F	1.1	1.2	1.4	1.2	1.1	1.1	-1.1
Latency to leave start box in cocaine runway, M	0.4	0.4	0.7	-0.2	-0.1	-0.8	0.8
Std. dev. time between licks in bursts	2.7	3.6	6.3	1.3	0.5	2.5	-2.5
Total sessions with >9 infusions	0.1	0.1	0.3	-0.2	0.5	-0.0	0.0
Short access day 1 total inactive lever presses	0.1	0.1	0.2	-0.2	0.2	0.4	-0.4
Short access day 10 total inactive lever presses	1.2	2.8	3.6	-1.0	-1.7	1.9	-1.9
Short access day 1 total infusions	0.6	0.8	2.0	0.7	1.4	-0.6	0.6
Short access day 10 total infusions	0.8	1.0	2.4	-1.6	-1.3	0.2	-0.2
Short access total infusions	0.1	0.1	0.6	-0.8	0.1	-0.0	0.0
Short access day 1 locomotion	0.2	0.3	0.5	-0.2	0.2	-0.7	0.7
Short access day 10 total locomotion	0.5	0.9	1.4	-0.8	-0.4	-1.2	1.2
Short access total locomotion	0.6	0.7	1.0	-1.0	-0.4	-0.9	0.9
One hour access (0.3 mA shock)	0.1	0.2	0.4	-0.6	-0.3	0.3	-0.3
Compulsive drug intake	1.3	1.5	3.0	0.3	-0.3	1.7	-1.7
One hour access (shock baseline)	0.1	0.2	0.7	-0.9	-0.1	-0.3	0.3
Social response proportion	0.3	0.4	0.7	0.8	0.8	0.3	-0.3
Social responses	0.2	0.2	0.3	0.2	0.4	0.5	-0.5
Social time	0.1	0.2	0.3	0.6	0.4	0.3	-0.3
Soleus weight	0.9	2.6	4.2	-1.6	-2.1	1.3	-1.3
Bone: stiffness	0.3	0.6	0.7	-0.5	-0.8	0.8	-0.8
Tibialis anterior weight	0.1	0.3	0.5	0.4	0.2	0.7	-0.7
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	0.2	0.4	-0.3	0.3
Time to tail flick, vehicle, after self-admin	0.8	1.0	2.0	0.6	1.4	-1.0	1.0
Time to tail flick, test, before self-admin	0.1	0.1	0.2	-0.1	0.2	-0.5	0.5
Time to tail flick, test, after self-admin	0.8	0.8	1.3	-0.5	0.5	-1.2	1.2
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.3	0.1	0.3	0.5	-0.5
Delta time to tail flick, test, before/after SA	0.6	0.6	1.2	-0.1	0.2	-1.1	1.1
Tibia length	6.3	17.3	35.8	-5.7	-6.0	0.8	-0.8
Ambulatory time before self-admin	1.2	1.8	3.8	-1.5	-1.9	0.8	-0.8
Ambulatory time after self-admin	0.7	0.8	1.5	-0.3	-0.5	1.2	-1.2
Bone: tissue strength	1.5	1.6	2.0	-0.8	-1.3	1.4	-1.4
Total heroin consumption	0.4	0.5	1.4	-1.2	-0.5	-0.4	0.4
Bone: trabecular number	0.0	0.0	0.1	-0.3	-0.2	-0.0	0.0
Bone: trabecular spacing	2.6	3.5	6.0	1.3	0.6	2.4	-2.4
Bone: trabecular thickness	2.0	2.5	3.1	-1.8	-1.5	-1.5	1.5
Bone: trabecular tissue density	0.5	0.8	1.5	1.2	1.2	-0.4	0.4
Water consumed over 24 hours	0.7	1.0	1.5	-0.8	-0.4	-1.2	1.2
Number of responses in last shaping day	0.1	0.1	0.2	-0.0	-0.0	0.5	-0.5