Hub : Genes

Mrpl10

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Mrpl10	0.02	0.02	3.9e-03	0.02	0.02	0.02	0.02	8.6e-04	3.1e-03	1.6e-03	1.1e-03
2	IL	gene expression	Mrpl10	0.44	0.16	4.8e-08	0.17	0.18	0.17	0.18	8.8e-05	4.2e-05	5.4e-05	4.8e-05
3	Liver	gene expression	Mrpl10	0.03	0.02	3.2e-04	0.01	0.02	0.01	0.01	3.0e-02	3.0e-03	7.4e-03	2.0e-02
4	PL	gene expression	Mrpl10	0.23	0.1	0.0e+00	0.32	0.32	0.32	0.32	1.8e-35	1.6e-36	1.7e-36	2.0e-36
5	Brain	gene expression	Mrpl10	0.11	0.07	1.7e-12	0.13	0.13	0.12	0.12	6.4e-12	7.5e-12	5.5e-11	1.1e-11
6	OFC	gene expression	Mrpl10	0.38	0.16	5.8e-07	0.21	0.2	0.22	0.25	1.1e-05	1.4e-05	5.8e-06	1.5e-06
7	BLA	gene expression	Mrpl10	0.23	0.11	2.1e-12	0.2	0.2	0.2	0.21	3.7e-11	3.6e-11	3.7e-11	2.5e-11

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bone: apparent density	1.5	2.5	2.9	-1.4	1.7	1.7	1.4	-1.7	1.6	1.5
Area under the delay curve	0.3	0.3	0.5	0.5	-0.6	-0.6	-0.7	0.4	-0.5	-0.3
BMI with tail	11.3	36.6	41.9	-6.2	5.5	5.6	6.5	-6.1	6.2	6.3
BMI without tail	1.3	2.7	3.4	-1.7	1.2	1.3	1.7	-1.8	1.8	1.7
Body weight	0.3	1.2	2.5	-1.5	-0.5	-0.4	1.6	-1.2	0.9	1.1
Weight adjusted by age	0.8	0.9	1.1	0.9	-0.9	-0.9	-0.9	1.1	-1.1	-0.9
Bone surface	0.3	0.5	0.9	-0.6	0.4	0.4	0.7	-0.9	1.0	0.6
Bone volume	1.0	1.7	2.4	-1.3	1.1	1.1	1.3	-1.5	1.5	1.3
Breakpoint value in progressive ratio session	4.8	5.3	6.1	2.5	-2.4	-2.4	-2.3	2.3	-2.0	-2.2
Number of licking bursts	0.0	0.0	0.1	0.2	0.0	-0.0	-0.3	0.3	-0.2	-0.3
Context. condit. distance diff. score	0.2	0.2	0.5	-0.4	0.3	0.3	0.6	-0.7	0.4	0.5
Locomotion velocity, session 1	0.4	0.4	0.8	-0.6	0.5	0.6	0.9	-0.7	0.3	0.7
Locomotion distance, session 1	3.0	3.9	4.9	1.7	-2.2	-2.2	-1.6	1.9	-2.2	-1.9
Locomotion velocity, session 2	1.1	1.3	2.0	1.0	-1.4	-1.4	-0.9	0.9	-1.3	-1.0
Locomotion distance, session 2	3.5	4.9	5.9	2.1	-2.4	-2.3	-2.0	2.1	-2.4	-2.2
Locomotion velocity, session 3	0.1	0.1	0.1	0.1	-0.4	-0.3	-0.2	0.3	-0.1	-0.2
Locomotion distance, session 3	3.5	3.8	4.6	1.9	-2.1	-2.1	-1.8	1.9	-1.7	-1.9
Stereotopy head waving bouts, day 3	4.7	5.5	6.6	-2.3	2.6	2.6	2.1	-2.3	2.2	2.3
Stereotopy head waving duration, day 3	3.1	3.7	4.1	-1.9	2.0	2.0	1.9	-1.9	1.7	2.0
Locomotion velocity, session 7	1.7	1.8	2.2	1.2	-1.5	-1.5	-1.3	1.3	-1.4	-1.3
Locomotion distance, session 7	5.2	6.5	7.1	2.5	-2.7	-2.7	-2.6	2.4	-2.4	-2.6
Stereotopy head waving bouts, day 7	0.8	0.9	1.2	-0.8	1.1	1.1	0.7	-0.7	1.1	0.9
Stereotopy head waving duration, day 7	0.3	0.4	0.6	-0.6	0.8	0.7	0.5	-0.3	0.8	0.6
Locomotion velocity, session 8	0.1	0.1	0.3	-0.3	-0.4	-0.3	0.5	-0.3	-0.1	0.2
Locomotion distance, session 8	0.9	1.3	1.9	0.9	-1.4	-1.3	-0.8	0.8	-1.4	-1.0
Degree of sensitization distance	0.0	0.0	0.0	0.1	-0.2	-0.2	-0.1	0.1	-0.2	-0.1
Degree of sensitization stereotypy	0.1	0.1	0.1	0.2	0.3	0.3	-0.3	0.4	0.4	-0.1
Conditioned locomotion	1.0	1.2	1.6	-1.2	1.0	1.0	1.1	-1.3	1.2	1.1
Cocaine response after cond. corrected	6.0	6.8	8.2	-2.6	2.5	2.5	2.5	-2.9	2.8	2.6
Cocaine response after cond. not corrected	3.4	3.8	4.8	-1.9	1.8	1.8	1.7	-2.2	2.1	1.9
Cocaine response before conditioning	2.3	2.7	3.4	1.6	-1.4	-1.5	-1.8	1.8	-1.7	-1.7
Saline control response	0.2	0.3	0.5	0.5	-0.3	-0.3	-0.7	0.6	-0.7	-0.6
Bone: connectivity density	0.2	0.3	0.7	-0.2	0.8	0.7	0.2	-0.5	0.9	0.4
Bone: cortical apparent density	5.3	7.1	9.9	3.1	-1.8	-2.0	-3.1	2.9	-2.5	-2.9
Bone: cortical area	0.0	0.0	0.1	-0.2	0.0	0.0	0.1	-0.2	-0.1	0.1
Bone: cortical porosity	0.6	0.6	1.0	-0.8	0.9	0.9	0.6	-0.7	1.0	0.7
Bone: cortical porosity	0.4	0.5	0.6	-0.7	0.7	0.8	0.5	-0.6	0.8	0.6
Bone: cortical thickness	0.3	0.4	0.6	0.7	-0.5	-0.5	-0.8	0.6	-0.8	-0.7
Bone: cortical thickness	1.1	1.2	2.0	1.1	-0.9	-0.9	-1.4	1.0	-1.0	-1.3
Bone: cortical tissue density	5.6	7.4	10.3	3.2	-1.9	-2.0	-3.1	2.9	-2.6	-2.9
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	0.4	-0.1	-0.1	-0.3	0.3	0.0	-0.3
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.8	-0.3	0.7	0.7	0.4	-0.4	0.9	0.6
Condit. Reinf. active responses	0.0	0.0	0.1	0.3	0.1	0.0	-0.3	0.2	0.1	-0.2
Condit. Reinf. inactive responses	0.2	0.3	0.5	0.6	-0.3	-0.3	-0.6	0.5	-0.4	-0.7
Incentive salience index mean	0.2	0.2	0.5	0.7	-0.2	-0.2	-0.6	0.6	-0.3	-0.5
Condit. Reinf. lever presses	0.7	1.0	1.6	1.3	-0.6	-0.6	-1.1	1.2	-0.9	-1.0
Condit. Reinf. active minus inactive responses	0.2	0.2	0.4	-0.4	0.6	0.6	0.3	-0.4	0.2	0.4
Condit. Reinf. active-inactive response ratio	0.5	0.6	0.9	-0.6	1.0	1.0	0.7	-0.6	0.6	0.7
Condit. Reinf. active responses	0.0	0.0	0.2	-0.2	0.4	0.4	-0.0	-0.1	-0.0	0.0
Condit. Reinf. inactive responses	0.2	0.2	0.5	0.4	-0.1	-0.1	-0.7	0.6	-0.6	-0.5
Condit. Reinf. lever presses	0.6	0.8	1.0	0.9	-0.7	-0.7	-0.9	1.0	-1.0	-1.0
Condit. Reinf. lever reinforcers received	0.0	0.0	0.1	0.1	0.2	0.2	-0.3	0.2	-0.3	-0.2
Conditioned reinforcement - actives	1.8	1.8	2.5	-1.2	1.6	1.6	1.1	-1.1	1.4	1.2
Conditioned reinforcement - inactives	0.6	0.7	1.1	0.9	-0.2	-0.3	-1.0	1.0	-0.8	-0.9
Conditioned locomotion	4.8	5.8	6.8	-2.6	2.6	2.6	2.3	-2.2	2.2	2.3
Patch foraging indifference point 0 sec	1.1	1.7	2.1	-1.4	1.3	1.3	1.1	-1.2	1.4	1.3
Patch foraging indifference point AUC	0.1	0.1	0.2	0.4	-0.3	-0.4	-0.3	0.4	-0.3	-0.3
Delay disc. indifference point, 0s delay	0.9	1.0	1.6	0.9	-0.9	-0.9	-1.3	1.2	-0.9	-0.9
Delay disc. indifference point, 16s delay	0.2	0.2	0.5	-0.5	0.3	0.3	0.4	-0.7	0.4	0.5
Delay disc. indifference point, 2s delay	0.3	0.3	0.6	0.4	-0.5	-0.5	-0.8	0.8	-0.6	-0.4
Delay disc. indifference point, 24s delay	0.4	0.4	0.5	0.7	-0.7	-0.7	-0.5	0.3	-0.5	-0.6
Delay disc. indifference point, 4s delay	3.9	4.1	5.1	1.9	-2.2	-2.2	-2.2	1.9	-1.8	-1.7
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	0.3	-0.2	-0.2	-0.4	0.1	-0.2	-0.1
Indifference point function ln k	0.0	0.0	0.1	-0.2	0.0	0.0	0.1	-0.3	0.2	0.0
Indifference point function log k	0.0	0.0	0.1	-0.2	0.0	0.0	0.1	-0.3	0.2	0.0
Patch foraging total patch changes 0 sec	1.0	1.6	2.2	-1.4	1.2	1.2	1.1	-1.2	1.5	1.3
Patch foraging total patch changes 12 sec	0.5	0.6	1.0	-0.7	1.0	0.9	0.4	-0.6	0.9	0.7
Patch foraging total patch changes 18 sec	1.6	2.1	2.4	-1.5	1.5	1.6	1.4	-1.2	1.5	1.4
Patch foraging total patch changes 24 sec	1.7	2.1	3.5	-1.4	1.4	1.4	1.2	-1.2	1.9	1.5
Patch foraging total patch changes 6 sec	1.2	1.7	2.1	-1.4	1.4	1.4	1.2	-1.2	1.3	1.3
Patch foraging time to switch 0 sec	0.1	0.1	0.3	-0.3	0.5	0.5	0.3	-0.3	0.3	0.3
Patch foraging water rate 0 sec	0.5	0.8	1.3	-1.1	0.5	0.5	0.9	-1.0	0.9	1.0
Patch foraging water rate 12 sec	0.2	0.3	0.6	0.2	-0.8	-0.8	-0.4	0.4	-0.3	-0.4
Patch foraging water rate 18 sec	0.6	0.8	1.2	0.8	-1.0	-0.9	-1.1	1.0	-0.6	-0.9
Patch foraging water rate 24 sec	0.5	0.7	0.9	-1.0	0.8	0.8	0.8	-0.9	0.9	0.8
Patch foraging water rate 6 sec	0.1	0.1	0.2	0.3	-0.1	-0.1	-0.4	0.3	-0.2	-0.3
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	0.6	-0.7	0.6	0.6	0.6	-0.8	0.6	0.2
Distance traveled before self-admin	0.6	0.6	0.9	0.8	-0.8	-0.8	-0.8	0.8	-0.9	-0.6
Distance traveled after self-admin	1.5	1.6	2.5	-1.4	0.9	0.9	1.4	-1.3	1.6	1.4
Extensor digitorum longus weight	0.1	0.5	1.1	-0.7	-0.9	-0.8	1.1	-0.6	-0.0	0.4
Bone: elastic displacement	0.1	0.2	0.2	-0.4	0.4	0.4	0.4	-0.4	0.2	0.5
Bone: elastic work	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.1	-0.2	-0.2	0.0
Bone: endosteal estimation	0.3	0.6	1.0	-1.0	0.1	0.1	1.0	-1.0	0.9	0.8
Bone: endosteal perimeter	0.4	0.8	1.2	-1.1	0.4	0.4	1.1	-1.1	0.9	1.0
Epididymis fat weight	0.0	0.0	0.1	-0.0	-0.3	-0.3	0.1	0.0	-0.4	-0.0
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	0.1	-0.4	-0.4	0.1	0.1	0.2	0.1
Delta time in open arm before/after self-admin	0.2	0.2	0.4	0.4	-0.2	-0.2	-0.5	0.4	-0.6	-0.5
Diff in mean of infusions in LGA sessions	0.5	0.6	1.0	1.0	-0.6	-0.6	-0.8	1.0	-0.1	-0.8
Delay discount exponential model param	0.4	0.4	0.6	-0.6	0.8	0.8	0.7	-0.5	0.6	0.4
Extinction: sum of active levers before priming	0.9	0.9	1.3	0.8	-1.1	-1.1	-0.9	0.8	-0.8	-0.9
Active lever presses in extinction session 6	0.2	0.2	0.2	-0.3	0.4	0.4	0.4	-0.5	0.2	0.5
Bone: final force	0.2	0.3	0.4	-0.6	0.6	0.6	0.4	-0.6	0.4	0.4
Bone: final moment	0.2	0.4	0.5	-0.7	0.6	0.6	0.5	-0.7	0.5	0.5
Food consumed during 24 hour testing period	1.3	1.6	1.8	1.2	-1.4	-1.4	-1.1	1.2	-1.2	-1.3
Glucose	0.4	0.6	1.1	-1.0	0.6	0.6	0.7	-0.9	0.6	0.7
Heart weight	0.7	1.0	1.8	-1.2	0.6	0.6	1.3	-1.2	0.7	1.2
Delay discount hyperbolic model param	0.7	0.7	1.0	-0.8	1.0	1.0	1.0	-0.7	0.8	0.6
Intermittent access intake day 1-15 change	2.1	2.1	2.4	-1.5	1.4	1.4	1.5	-1.4	1.3	1.5
Intermittent access intake escalation	2.3	2.2	2.5	-1.6	1.5	1.5	1.5	-1.4	1.4	1.6
Intermittent access intake escalation 2	1.5	1.5	1.8	-1.3	1.1	1.1	1.3	-1.1	1.2	1.3
Intermitt. access day 1 inactive lever presses	0.4	0.4	0.7	0.8	-0.2	-0.2	-0.8	0.7	-0.7	-0.8
Intermitt. access day 15 inactive lever presses	0.5	0.5	1.4	-0.3	1.2	1.1	0.4	-0.4	0.5	0.5
Intermitt. access escalation Index	3.0	2.7	4.0	-1.8	1.1	1.2	1.7	-1.8	2.0	1.7
Intermittent access day 1 total infusions	0.1	0.1	0.3	0.4	-0.2	-0.3	-0.4	0.4	-0.2	-0.5
Intermittent access day 15 total infusions	0.3	0.4	0.6	-0.6	0.7	0.7	0.5	-0.5	0.8	0.6
Intermittent access terminal intake (last 3 days)	0.3	0.3	0.5	-0.5	0.7	0.7	0.5	-0.4	0.7	0.5
Intermittent access total infusions	0.0	0.0	0.2	-0.1	0.2	0.2	0.1	-0.1	0.4	0.1
Intermittent access day 1 locomotion	0.1	0.1	0.2	0.4	-0.2	-0.2	-0.4	0.4	-0.2	-0.5
Intermittent access day 15 total locomotion	0.3	0.4	0.6	-0.6	0.8	0.7	0.5	-0.5	0.5	0.5
Intermittent access total locomotion	0.7	0.8	1.1	-0.9	1.1	1.1	0.8	-0.9	0.8	0.8
Intermittent access standard deviation	1.5	1.6	2.1	-1.3	1.2	1.3	1.2	-1.2	1.2	1.4
Left kidney weight	0.3	0.8	2.5	0.1	-1.6	-1.5	-0.1	0.1	-0.8	-0.5
Right kidney weight	0.2	0.5	1.0	-1.0	-0.1	-0.1	0.9	-0.9	0.4	0.7
Cocaine induced anxiety	0.0	0.0	0.1	-0.2	-0.1	-0.1	0.3	-0.1	0.1	0.3
Post-drug Anxiety	0.5	0.5	0.8	0.8	-0.5	-0.5	-0.7	0.9	-0.9	-0.8
Baseline Anxiety	0.1	0.2	0.4	0.2	0.6	0.6	-0.3	0.3	-0.1	-0.3
Tail length	11.0	33.2	42.0	5.5	-6.5	-6.5	-5.6	5.4	-5.2	-5.6
Length with tail	8.1	29.8	42.8	4.7	-6.5	-6.5	-4.8	4.8	-5.3	-5.2
Length without tail	0.6	1.3	2.8	0.5	-1.7	-1.6	-0.5	0.8	-1.4	-1.0
Times rat made contact with spout	0.0	0.0	0.1	0.2	0.1	0.1	-0.2	0.1	-0.1	-0.1
Lifetime Intake	0.0	0.0	0.1	0.0	0.1	0.0	-0.0	0.1	0.3	-0.1
Liver weight, left	1.1	1.7	3.3	1.3	-1.3	-1.3	-1.2	1.1	-1.8	-1.2
Liver weight, right	1.6	2.7	3.6	1.3	-1.8	-1.8	-1.5	1.3	-1.9	-1.6
Locomotor activity	0.9	1.4	1.9	-1.1	1.4	1.3	1.0	-0.9	1.4	1.0
Locomotor testing distance	1.7	2.9	4.7	-1.4	2.2	2.1	1.2	-1.3	1.9	1.4
Locomotor testing rearing	0.2	0.4	1.1	-0.1	1.0	1.0	-0.1	-0.0	0.6	0.2
Locomotion in novel chamber	0.6	0.8	1.3	1.0	-0.6	-0.7	-1.1	0.9	-0.8	-0.9
Locomotion in novel chamber post-restriction	2.0	2.5	3.1	-1.5	1.8	1.8	1.5	-1.5	1.3	1.6
Fecal boli incidents, locomotor time 1	2.4	2.7	3.1	-1.7	1.5	1.5	1.8	-1.8	1.4	1.7
Change in fecal boli incidents, locomotor task	2.1	2.0	2.4	1.5	-1.4	-1.4	-1.5	1.5	-1.3	-1.3
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	0.4	0.1	0.0	-0.4	0.3	0.1	-0.2
Bouts of movement, locomotor time 1	0.0	0.0	0.1	-0.0	-0.0	-0.0	0.2	-0.4	-0.1	-0.0
Total resting periods, locomotor time 1	0.1	0.1	0.3	-0.2	0.0	-0.0	0.4	-0.5	-0.1	0.1
Rest time, locomotor task time 1	0.2	0.2	0.3	-0.5	0.3	0.3	0.4	-0.6	-0.1	0.5
Distance moved, locomotor task time 1	0.8	0.8	1.3	1.1	-0.9	-0.9	-1.1	1.0	-0.3	-0.8
Vertical activity count, locomotor time 1	0.1	0.1	0.2	0.5	-0.3	-0.3	-0.4	0.3	0.3	-0.4
Time >=10cm from walls, locomotor time 2	0.4	0.5	0.8	0.8	-0.4	-0.4	-0.9	0.9	-0.5	-0.7
Bouts of movement, locomotor time 2	0.1	0.1	0.2	-0.1	0.4	0.4	0.3	-0.4	0.2	0.3
Total resting periods, locomotor time 2	0.1	0.1	0.2	-0.2	0.5	0.5	0.3	-0.4	0.2	0.3
Rest time, locomotor task time 2	1.0	1.1	1.8	1.1	-1.0	-1.0	-1.0	1.0	-1.3	-1.0
Distance moved, locomotor task time 2	0.1	0.2	0.5	0.2	-0.7	-0.6	-0.3	0.3	0.0	-0.1
Vertical activity count, locomotor time 2	0.1	0.2	0.6	-0.3	-0.1	-0.1	0.3	-0.3	0.8	0.5
Light reinforcement 1	0.6	1.1	2.2	-0.8	1.5	1.5	0.7	-0.7	1.0	0.8
Light reinforcement 2	0.1	0.2	0.5	-0.3	0.5	0.5	0.2	-0.3	0.7	0.3
Bone: marrow area	0.2	0.4	0.8	-0.8	-0.0	0.0	0.9	-0.9	0.7	0.7
Bone: maximum diameter	0.4	0.7	0.9	-1.0	0.7	0.7	0.9	-1.0	0.9	0.9
Bone: maximum force	0.4	0.8	1.4	-1.0	0.6	0.7	1.0	-1.2	0.7	0.8
Bone: maximum moment	0.5	0.8	1.5	-1.1	0.6	0.6	1.0	-1.2	0.7	0.8
Mean time between licks in bursts	0.1	0.1	0.2	-0.3	0.1	0.1	0.5	-0.4	0.3	0.4
Mean num. licks in bursts	0.1	0.1	0.1	0.3	-0.2	-0.2	-0.3	0.2	-0.3	-0.2
Cd content in liver	0.6	0.6	1.0	1.0	-0.6	-0.7	-0.9	0.8	-0.6	-0.8
Co content in liver	0.0	0.0	0.1	-0.1	-0.2	-0.2	0.2	-0.2	0.3	0.1
Cu content in liver	1.6	2.0	2.3	1.5	-1.4	-1.5	-1.4	1.5	-1.1	-1.5
Fe content in liver	1.7	2.1	3.0	1.3	-1.7	-1.7	-1.2	1.3	-1.3	-1.5
K content in liver	0.1	0.1	0.4	-0.3	0.3	0.3	0.3	-0.3	0.6	0.4
Mg content in liver	0.7	0.7	0.9	0.9	-0.7	-0.7	-0.9	0.9	-0.7	-0.9
Mn content in liver	1.9	2.1	3.0	1.7	-1.1	-1.1	-1.7	1.7	-1.3	-1.5
Na content in liver	1.0	1.0	1.3	-0.9	1.1	1.1	0.9	-0.8	1.1	1.0
Rb content in liver	0.1	0.1	0.3	0.2	0.3	0.3	-0.3	0.4	-0.6	-0.5
Se content in liver	0.1	0.1	0.3	-0.3	0.5	0.5	0.2	-0.3	0.2	0.4
Sr content in liver	1.8	1.7	2.1	1.3	-1.4	-1.4	-1.3	1.3	-1.2	-1.1
Zn content in liver	0.1	0.1	0.3	-0.1	0.6	0.5	-0.0	0.0	0.3	0.2
Bone: minimum diameter	0.0	0.1	0.1	-0.3	-0.3	-0.3	0.3	-0.4	0.0	0.2
Time in familiar zone, hab. session 1	0.3	0.3	0.6	0.8	-0.2	-0.2	-0.7	0.6	-0.5	-0.7
Time in novel zone, hab. session 1	3.0	2.9	3.2	-1.8	1.7	1.7	1.6	-1.7	1.6	1.8
Total zone transitions, hab. session 1	6.8	9.6	10.0	3.0	-3.2	-3.1	-2.9	3.1	-3.1	-3.2
Total locomotion distance, hab. session 1	2.8	4.0	5.4	2.0	-1.8	-1.8	-1.9	2.0	-2.3	-2.1
Locomotion velocity, hab. session 1	3.9	5.6	7.0	2.3	-2.3	-2.3	-2.2	2.3	-2.7	-2.4
Time in familiar zone, hab. session 2	0.4	0.4	0.8	-0.4	0.9	0.9	0.5	-0.4	0.6	0.6
Time in novel zone, hab. session 2	0.1	0.1	0.1	0.1	-0.3	-0.3	-0.2	0.1	-0.3	-0.2
Total zone transitions, hab. session 2	1.7	2.2	2.7	1.6	-1.4	-1.4	-1.4	1.5	-1.6	-1.6
Total locomotion distance, hab. session 2	0.1	0.1	0.5	0.2	-0.1	-0.1	-0.1	0.1	-0.7	-0.2
Locomotion velocity, hab. session 2	0.1	0.2	0.6	0.3	-0.3	-0.3	-0.2	0.2	-0.8	-0.3
Novel to familiar place preference ratio	1.0	1.0	1.9	0.8	-1.4	-1.4	-0.8	0.7	-0.7	-1.0
Novelty place preference	1.1	1.1	2.0	0.9	-1.4	-1.4	-1.0	0.7	-0.8	-1.0
Time in novel zone, NPP test	0.8	0.8	1.3	0.8	-1.1	-1.2	-0.9	0.6	-0.6	-0.9
Total zone transitions, NPP test	3.8	5.4	6.9	2.3	-2.2	-2.1	-2.2	2.5	-2.6	-2.3
Total locomotion distance, NPP test	1.0	1.4	2.7	1.1	-0.9	-0.9	-1.1	1.3	-1.7	-1.2
Locomotion velocity, NPP test	1.7	2.4	4.1	1.4	-1.5	-1.4	-1.4	1.6	-2.0	-1.5
Intraocular pressure	1.1	1.5	2.5	1.2	-1.6	-1.6	-1.1	0.9	-0.6	-1.3
Delta distance traveled before/after self-admin	3.2	3.5	4.7	-2.0	1.6	1.6	2.0	-1.9	2.2	1.8
Delta ambulatory time before/after self-admin	3.2	3.6	4.5	-2.0	1.6	1.7	2.0	-1.9	2.1	1.8
Parametrial fat weight	0.1	0.2	0.6	-0.2	0.5	0.4	0.2	-0.4	0.8	0.3
Pavlov. Cond. lever latency	1.3	1.6	2.5	-1.5	0.7	0.7	1.5	-1.6	1.2	1.3
Pavlov. Cond. magazine entry latency	0.2	0.2	0.7	0.1	0.8	0.8	-0.3	-0.0	0.3	0.1
Pavlov. Cond. change in total contacts	1.5	1.6	2.8	1.6	-0.6	-0.7	-1.7	1.5	-1.0	-1.5
Pavlov. Cond. index score	0.3	0.4	1.0	0.9	0.2	0.2	-1.0	0.8	-0.4	-0.6
Pavlov. Cond. latency score	0.4	0.6	1.1	1.0	0.0	-0.0	-1.1	0.9	-0.6	-0.8
Pavlov. Cond. lever contacts	1.6	1.8	2.7	1.7	-0.8	-0.8	-1.6	1.6	-1.2	-1.5
Pavlov. Cond. magazine entry number	0.2	0.3	0.6	-0.5	-0.7	-0.7	0.7	-0.4	0.1	0.3
Pavlov. Cond. intertrial magazine entries	0.6	0.7	1.2	0.7	-1.1	-1.1	-0.7	0.7	-0.7	-0.8
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.9	0.8	0.3	0.2	-0.9	0.8	-0.3	-0.6
Pavlov. Cond. response bias	0.4	0.4	0.9	0.9	0.3	0.2	-1.0	0.8	-0.3	-0.7
Pavlov. Cond. lever latency	0.6	0.8	1.0	1.0	-1.0	-1.0	-0.8	0.8	-0.8	-0.8
Pavlov. Cond. magazine entry latency	0.5	0.6	0.8	0.7	-0.9	-0.9	-0.7	0.7	-0.8	-0.7
Pavlov. Cond. change in total contacts	0.2	0.3	0.5	-0.7	0.7	0.7	0.5	-0.5	0.4	0.5
Pavlov. Cond. index score	0.2	0.3	0.4	-0.6	0.5	0.5	0.5	-0.6	0.5	0.5
Pavlov. Cond. latency score	0.1	0.1	0.2	-0.4	0.2	0.3	0.3	-0.3	0.3	0.3
Pavlov. Cond. lever contacts	0.5	0.7	1.0	-0.9	1.0	1.0	0.7	-0.7	0.7	0.8
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	0.1	0.1	0.1	0.0	0.1	-0.0	-0.0
Pavlov. Cond. intertrial magazine entries	1.8	2.4	2.7	1.5	-1.6	-1.6	-1.4	1.5	-1.7	-1.6
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.5	-0.7	0.5	0.5	0.6	-0.6	0.5	0.6
Pavlov. Cond. response bias	0.5	0.7	0.9	-0.9	0.9	0.9	0.7	-0.7	0.7	0.8
Time in closed arm before self-admin	0.6	0.7	1.2	-0.9	1.1	1.1	0.7	-0.7	0.4	0.7
Time in closed arm after self-admin	0.3	0.3	0.5	-0.6	0.4	0.4	0.7	-0.5	0.7	0.6
Time in open arm before self-admin	0.1	0.1	0.2	0.0	-0.4	-0.4	0.1	0.2	0.1	-0.1
Time in open arm after self-admin	0.2	0.3	0.5	0.5	-0.4	-0.4	-0.4	0.6	-0.7	-0.6
Bone: periosteal estimation	0.3	0.6	1.0	-0.9	0.4	0.4	0.9	-1.0	0.8	0.8
Bone: periosteal perimeter	0.2	0.4	0.6	-0.7	0.2	0.2	0.8	-0.8	0.6	0.7
Bone: post-yield work	0.1	0.2	0.5	-0.4	0.0	0.0	0.5	-0.7	0.4	0.3
Progressive ratio test 1 active lever presses	0.0	0.0	0.1	0.1	-0.0	-0.1	-0.2	0.1	0.0	-0.2
Progressive ratio test 1 breakpoint	0.1	0.1	0.3	0.4	-0.3	-0.3	-0.5	0.4	-0.3	-0.4
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.2	-0.1	0.5	0.5	0.1	-0.2	0.2	0.1
Progressive ratio test 2 active lever presses	0.0	0.0	0.0	0.2	0.2	0.2	-0.2	0.2	-0.0	-0.1
Progressive ratio test 2 breakpoint	0.0	0.0	0.1	0.1	0.3	0.2	-0.1	0.1	0.1	-0.0
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.3	0.4	-0.1	-0.1	-0.4	0.5	-0.2	-0.4
Incentive Sensitization - Responses	0.1	0.1	0.2	-0.1	0.4	0.4	0.1	-0.1	0.1	0.2
Incentive Sensitization - Breakpoint	0.2	0.2	0.3	-0.3	0.6	0.6	0.3	-0.3	0.3	0.4
Sum of active levers in priming session hrs 5-6	3.2	3.1	4.4	1.9	-1.6	-1.6	-1.9	2.1	-1.4	-1.7
Progressive ratio	0.6	0.6	1.3	0.7	-0.6	-0.6	-0.8	1.0	-1.2	-0.6
Food seeking constrained by brief footshock	0.7	0.8	1.3	-0.9	0.9	0.9	0.9	-1.1	0.8	0.7
Seeking ratio, punishment vs. effort	0.8	0.9	1.8	-0.7	0.8	0.8	0.9	-1.3	1.3	0.6
Retroperitoneal fat weight	0.2	0.7	1.3	-1.2	0.4	0.4	1.0	-1.1	0.3	1.0
Reaction time number correct	0.3	0.4	0.5	0.5	-0.6	-0.6	-0.5	0.6	-0.7	-0.7
Reaction time mean minus median	0.1	0.1	0.3	0.3	-0.2	-0.2	-0.4	0.5	-0.3	-0.5
Reaction time mean minus median AUC	0.2	0.2	0.4	0.5	-0.0	-0.1	-0.6	0.6	-0.4	-0.6
Reaction time num false alarms	0.1	0.2	0.4	0.5	-0.2	-0.2	-0.6	0.6	-0.3	-0.4
Reaction time num false alarms AUC	0.2	0.3	0.6	0.6	-0.3	-0.3	-0.7	0.7	-0.3	-0.5
Reaction time trials correct on left	0.3	0.4	0.5	0.5	-0.6	-0.6	-0.5	0.6	-0.7	-0.7
Reaction time trials on left	0.3	0.4	0.5	0.5	-0.6	-0.6	-0.5	0.6	-0.7	-0.7
Reaction time mean	0.2	0.3	0.5	-0.5	0.7	0.6	0.5	-0.5	0.6	0.4
Reaction time mean AUC	0.2	0.2	0.4	-0.4	0.6	0.6	0.4	-0.5	0.5	0.3
Median of all reaction times	0.6	0.8	1.2	-0.7	1.1	1.0	0.8	-0.8	0.8	0.8
Reaction time omissions	0.0	0.1	0.1	-0.2	0.4	0.3	0.1	-0.3	0.1	0.0
Reaction time false alarm rate	0.0	0.0	0.1	0.1	0.2	0.1	-0.3	0.2	0.2	0.0
Reaction time premature initiation rate	0.2	0.3	0.4	0.5	-0.5	-0.5	-0.7	0.6	-0.3	-0.5
Reaction time premature initiations	0.6	0.8	1.0	0.8	-0.9	-0.9	-1.0	1.0	-0.8	-0.9
Std. dev. reaction times	0.0	0.0	0.1	0.1	0.0	-0.0	-0.2	0.2	-0.2	-0.3
Reaction time trials completed	0.3	0.4	0.5	0.5	-0.6	-0.6	-0.5	0.6	-0.7	-0.7
Reaction time trials AUC	0.3	0.4	0.5	0.5	-0.6	-0.6	-0.5	0.6	-0.7	-0.7
Run reversals in cocaine runway, females	0.2	0.2	0.6	0.3	-0.8	-0.7	-0.2	0.2	-0.0	-0.1
Run reversals in cocaine runway, males	1.1	1.0	2.1	-0.9	1.4	1.4	0.9	-0.7	0.5	0.9
Latency to leave start box in cocaine runway	1.9	2.0	3.0	-1.5	1.1	1.2	1.7	-1.4	1.6	1.4
Latency to leave start box in cocaine runway, F	3.2	3.5	4.9	-2.1	1.5	1.6	2.2	-2.0	1.7	1.9
Latency to leave start box in cocaine runway, M	0.5	0.5	1.5	-0.4	0.5	0.5	0.8	-0.7	1.2	0.6
Std. dev. time between licks in bursts	1.2	1.4	1.6	-1.2	1.1	1.1	1.3	-1.2	1.1	1.3
Total sessions with >9 infusions	0.5	0.6	0.7	-0.8	0.8	0.8	0.7	-0.8	0.8	0.7
Short access day 1 total inactive lever presses	3.4	3.8	5.3	2.3	-1.3	-1.4	-2.2	2.2	-1.9	-2.1
Short access day 10 total inactive lever presses	1.1	1.2	1.8	1.3	-0.8	-0.8	-1.0	1.1	-1.3	-1.1
Short access day 1 total infusions	0.0	0.0	0.0	0.1	0.1	0.1	-0.1	0.2	0.1	-0.1
Short access day 10 total infusions	0.4	0.4	0.7	-0.6	0.6	0.6	0.6	-0.6	0.9	0.7
Short access total infusions	0.0	0.0	0.1	-0.1	0.1	0.1	0.1	-0.0	0.4	0.1
Short access day 1 locomotion	0.7	0.8	1.1	-0.9	1.1	1.1	0.7	-0.8	0.8	0.9
Short access day 10 total locomotion	0.3	0.4	0.7	-0.6	0.8	0.8	0.5	-0.5	0.3	0.6
Short access total locomotion	0.6	0.6	0.9	-0.9	0.9	0.9	0.8	-0.7	0.6	0.7
One hour access (0.3 mA shock)	0.4	0.5	0.8	0.9	-0.5	-0.6	-0.8	0.8	-0.5	-0.7
Compulsive drug intake	6.7	6.7	7.7	2.8	-2.5	-2.6	-2.7	2.6	-2.3	-2.6
One hour access (shock baseline)	2.5	2.9	3.2	-1.7	1.8	1.8	1.6	-1.6	1.8	1.6
Social response proportion	0.8	0.8	1.3	0.7	-1.0	-1.0	-1.0	0.7	-1.1	-0.9
Social responses	0.0	0.1	0.3	0.1	-0.1	-0.1	-0.2	-0.1	-0.5	-0.2
Social time	0.0	0.0	0.1	0.0	0.3	0.3	0.1	0.0	0.3	0.1
Soleus weight	0.8	2.4	2.7	-1.6	1.6	1.6	1.6	-1.6	1.1	1.6
Bone: stiffness	0.0	0.1	0.2	-0.3	0.1	0.1	0.3	-0.4	0.3	0.0
Tibialis anterior weight	0.4	1.2	2.2	0.7	-1.4	-1.3	-0.7	0.8	-1.5	-1.0
Time to tail flick, vehicle, before self-admin	1.7	1.7	2.5	1.6	-1.1	-1.2	-1.4	1.3	-0.8	-1.5
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.3	-0.3	0.4	0.4	0.3	-0.3	0.5	0.3
Time to tail flick, test, before self-admin	0.0	0.0	0.0	0.0	-0.0	-0.0	0.1	-0.2	0.1	0.1
Time to tail flick, test, after self-admin	0.1	0.1	0.3	-0.3	0.1	0.1	0.4	-0.5	0.6	0.3
Delta time to tail flick, vehicle, before/after SA	1.3	1.3	1.4	-1.2	1.2	1.2	1.1	-1.1	0.9	1.2
Delta time to tail flick, test, before/after SA	0.1	0.1	0.1	0.2	-0.3	-0.3	-0.4	0.2	-0.2	-0.2
Tibia length	0.2	0.7	1.3	-1.1	0.2	0.3	1.1	-1.1	0.6	0.8
Ambulatory time before self-admin	0.3	0.4	0.6	0.5	-0.6	-0.6	-0.6	0.6	-0.8	-0.4
Ambulatory time after self-admin	1.9	2.1	3.0	-1.6	0.8	0.9	1.7	-1.5	1.7	1.5
Bone: tissue strength	0.1	0.1	0.2	-0.2	0.2	0.2	0.5	-0.5	0.0	0.4
Total heroin consumption	1.5	1.8	2.5	1.6	-1.0	-1.1	-1.4	1.4	-1.3	-1.5
Bone: trabecular number	0.8	1.2	2.3	-0.8	1.5	1.5	0.7	-1.0	1.1	0.9
Bone: trabecular spacing	0.0	0.1	0.3	0.1	-0.1	-0.1	-0.0	0.3	-0.6	-0.1
Bone: trabecular thickness	1.3	1.5	2.1	-1.2	0.9	0.9	1.3	-1.5	1.4	1.3
Bone: trabecular tissue density	0.2	0.3	1.3	0.4	-0.3	-0.3	-0.4	0.5	-1.1	-0.5
Water consumed over 24 hours	0.2	0.2	0.3	0.5	-0.3	-0.3	-0.5	0.5	-0.4	-0.5
Number of responses in last shaping day	0.0	0.0	0.1	-0.2	0.2	0.2	0.2	-0.2	0.1	0.2