Hub : Genes

Mrc2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability Mrc2 0.07 0.03 8.1e-08 0.07 0.06 0.06 0.06 8.1e-08 1.3e-07 9.7e-08 3.1e-07
2 PL gene expression Mrc2 0.11 0.05 5.1e-14 0.07 0.12 0.11 0.12 1.9e-08 3.0e-13 2.9e-12 2.9e-13
3 NAcc gene expression Mrc2 0.25 0.12 2.7e-12 0.04 0.07 0.09 0.07 1.1e-05 1.1e-08 1.4e-10 3.9e-08
4 BLA gene expression Mrc2 0.09 0.06 5.4e-03 0.03 0.03 0.01 0.03 9.7e-03 1.0e-02 9.1e-02 1.4e-02
5 pVTA gene expression Mrc2 0.1 0.06 2.6e-03 0.01 0.04 0.03 0.02 1.3e-01 1.1e-02 2.4e-02 6.6e-02
6 Brain gene expression Mrc2 0.27 0.09 0.0e+00 0.27 0.3 0.3 0.29 2.8e-25 4.3e-28 9.7e-29 5.6e-27
7 Liver gene expression Mrc2 0.05 0.03 3.6e-04 0.03 0.02 0.02 0.02 4.1e-04 3.3e-03 6.4e-03 2.2e-03
8 Adipose gene expression Mrc2 0.1 0.05 8.0e-10 0.06 0.08 0.07 0.08 3.7e-07 1.9e-09 1.1e-08 2.9e-09
9 PL alternative TSS XM_006247631.4 0.04 0.03 3.7e-03 0.02 0.01 0.01 0.02 1.8e-03 1.9e-02 9.4e-03 4.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density1.42.311.0-2.20.7-0.7-1.10.00.83.3-0.7-1.3
Area under the delay curve0.30.30.6-0.70.5-0.5-0.70.6-0.8-0.10.60.2
BMI with tail1.85.913.31.00.8-0.4-1.41.8-3.4-3.72.93.6
BMI without tail1.73.48.8-1.01.9-0.9-0.82.3-2.7-1.63.00.7
Body weight2.811.722.4-2.63.8-3.2-3.04.4-4.6-1.24.70.6
Weight adjusted by age0.70.82.3-0.10.4-0.9-0.90.8-1.1-1.51.00.6
Bone surface4.27.514.7-3.82.9-3.4-3.62.1-1.23.41.1-0.9
Bone volume3.35.612.9-3.62.4-2.6-2.91.8-0.83.30.8-1.2
Breakpoint value in progressive ratio session0.90.91.8-0.91.2-1.3-0.91.1-0.80.70.8-0.8
Number of licking bursts0.30.30.9-0.10.3-0.6-0.80.5-1.00.20.50.5
Context. condit. distance diff. score0.70.82.21.5-0.60.70.5-0.1-0.6-1.50.31.1
Locomotion velocity, session 11.21.33.6-1.91.0-1.1-0.70.50.51.8-0.0-1.4
Locomotion distance, session 10.40.51.5-1.20.2-0.20.10.00.90.9-0.2-1.2
Locomotion velocity, session 21.41.66.5-1.20.7-1.2-0.5-0.10.92.5-0.8-1.7
Locomotion distance, session 20.30.51.6-0.30.1-0.20.3-0.30.91.0-0.6-1.3
Locomotion velocity, session 30.20.31.0-0.4-0.3-0.3-0.3-0.51.00.5-0.7-0.3
Locomotion distance, session 30.30.30.9-0.40.1-0.7-0.9-0.20.40.9-0.50.2
Stereotopy head waving bouts, day 30.81.03.10.0-1.01.00.7-1.11.80.5-1.2-0.6
Stereotopy head waving duration, day 30.50.61.20.1-0.70.91.1-0.61.1-0.3-0.5-0.7
Locomotion velocity, session 70.40.40.70.4-0.80.70.4-0.80.70.4-0.80.1
Locomotion distance, session 70.10.20.40.6-0.50.60.5-0.40.1-0.4-0.20.1
Stereotopy head waving bouts, day 70.91.02.60.4-1.10.80.5-1.21.60.8-1.4-0.3
Stereotopy head waving duration, day 72.22.75.61.0-1.71.41.4-1.92.41.2-2.2-0.8
Locomotion velocity, session 81.21.52.6-0.91.5-1.6-0.81.5-1.4-0.11.5-0.7
Locomotion distance, session 80.20.31.00.6-0.20.51.0-0.20.2-0.1-0.1-0.8
Degree of sensitization distance0.50.51.50.40.10.60.90.5-0.9-1.20.9-0.2
Degree of sensitization stereotypy1.11.22.71.0-1.30.70.5-1.41.40.6-1.60.3
Conditioned locomotion0.10.20.60.3-0.00.70.8-0.1-0.10.30.0-0.4
Cocaine response after cond. corrected0.80.93.60.1-0.1-0.7-1.60.1-0.4-1.10.21.9
Cocaine response after cond. not corrected0.91.04.4-0.1-0.3-1.1-2.1-0.30.2-0.2-0.51.7
Cocaine response before conditioning0.70.92.9-0.5-0.3-0.3-0.2-0.71.21.7-1.2-1.1
Saline control response0.60.82.2-0.31.2-0.50.21.1-1.50.11.1-0.5
Bone: connectivity density1.52.411.1-2.20.9-1.0-1.30.20.73.3-0.6-1.2
Bone: cortical apparent density5.47.113.01.8-3.03.63.4-2.93.3-0.1-2.6-0.7
Bone: cortical area1.72.56.3-2.21.5-1.8-2.51.4-1.11.21.10.4
Bone: cortical porosity13.514.733.0-4.04.1-5.6-5.73.5-3.22.52.40.3
Bone: cortical porosity9.910.725.4-3.33.4-4.8-5.03.1-2.91.62.30.7
Bone: cortical thickness1.62.75.20.8-2.31.90.3-2.12.0-0.0-2.01.5
Bone: cortical thickness2.32.75.60.9-2.21.30.1-2.22.30.5-2.41.1
Bone: cortical tissue density5.36.912.61.8-3.03.53.4-2.93.2-0.1-2.6-0.8
Condit. Reinf. active minus inactive responses1.71.93.2-1.71.8-1.8-1.11.3-0.91.40.9-1.1
Condit. Reinf. active-inactive response ratio0.30.30.7-0.40.7-0.9-0.80.4-0.50.80.10.0
Condit. Reinf. active responses2.02.44.2-2.02.0-1.6-0.81.5-0.71.91.0-1.8
Condit. Reinf. inactive responses1.11.33.8-1.71.2-0.60.20.90.11.30.7-2.0
Incentive salience index mean1.61.94.9-1.81.6-1.6-1.21.0-0.32.20.4-1.2
Condit. Reinf. lever presses0.60.94.4-0.90.5-0.4-0.3-0.00.72.1-0.5-1.2
Condit. Reinf. active minus inactive responses3.44.39.6-2.72.3-2.5-2.21.5-0.93.10.7-1.4
Condit. Reinf. active-inactive response ratio2.93.18.1-2.11.8-2.1-2.11.1-0.72.80.4-0.8
Condit. Reinf. active responses3.75.19.4-3.12.7-2.5-1.72.0-1.03.01.2-2.3
Condit. Reinf. inactive responses1.41.86.6-1.81.4-0.70.51.1-0.21.20.9-2.6
Condit. Reinf. lever presses1.11.53.6-1.51.4-1.5-1.20.9-0.51.90.4-1.1
Condit. Reinf. lever reinforcers received3.14.48.0-2.82.4-2.3-1.71.8-1.02.81.1-2.0
Conditioned reinforcement - actives0.40.41.2-0.20.6-0.2-0.00.9-0.8-0.41.1-0.1
Conditioned reinforcement - inactives0.30.30.7-0.40.7-0.4-0.60.7-0.50.20.80.1
Conditioned locomotion1.21.52.6-1.31.6-1.2-1.21.5-1.20.41.5-0.0
Patch foraging indifference point 0 sec1.32.15.0-2.01.7-0.8-0.01.5-0.91.51.2-2.2
Patch foraging indifference point AUC0.60.71.8-0.61.0-0.30.21.1-1.30.21.2-0.7
Delay disc. indifference point, 0s delay0.10.10.30.0-0.40.20.3-0.50.4-0.2-0.5-0.3
Delay disc. indifference point, 16s delay1.11.12.5-0.90.9-0.8-1.41.1-1.6-0.31.20.8
Delay disc. indifference point, 2s delay0.91.03.3-1.80.8-0.60.00.40.31.20.0-1.6
Delay disc. indifference point, 24s delay1.31.32.7-1.31.4-0.8-0.61.5-1.4-0.21.7-0.4
Delay disc. indifference point, 4s delay0.40.52.3-0.50.1-1.0-1.50.1-0.3-0.3-0.10.7
Delay disc. indifference point, 8s delay0.40.40.8-0.1-0.70.90.6-0.80.80.3-0.7-0.1
Indifference point function ln k0.30.41.2-0.7-0.30.0-0.2-0.41.10.8-0.7-0.3
Indifference point function log k0.30.41.2-0.7-0.30.0-0.2-0.41.10.8-0.7-0.3
Patch foraging total patch changes 0 sec1.72.75.2-2.32.0-1.2-0.51.8-1.21.51.5-2.1
Patch foraging total patch changes 12 sec1.31.75.2-1.31.6-0.50.71.2-0.91.51.1-2.3
Patch foraging total patch changes 18 sec1.51.94.3-1.11.7-1.4-1.21.6-2.10.51.5-0.2
Patch foraging total patch changes 24 sec1.82.14.1-2.01.7-1.0-0.41.5-1.01.51.2-2.0
Patch foraging total patch changes 6 sec1.01.52.4-1.51.6-1.1-0.71.4-1.31.11.2-1.2
Patch foraging time to switch 0 sec0.10.10.30.4-0.2-0.2-0.4-0.40.30.3-0.60.5
Patch foraging water rate 0 sec0.71.12.0-1.41.2-0.8-0.61.3-1.10.41.4-0.6
Patch foraging water rate 12 sec0.40.62.10.3-0.90.0-0.8-0.50.6-1.0-0.31.5
Patch foraging water rate 18 sec0.50.72.8-0.4-0.60.3-0.0-0.81.70.9-1.1-0.4
Patch foraging water rate 24 sec0.20.30.50.5-0.50.2-0.2-0.70.5-0.2-0.60.7
Patch foraging water rate 6 sec0.10.20.5-0.7-0.1-0.0-0.4-0.00.40.7-0.2-0.1
Seeking ratio, delayed vs. immediate footshock0.50.61.30.00.5-0.4-0.20.8-1.1-1.11.00.6
Distance traveled before self-admin1.51.65.1-0.40.7-1.8-2.30.9-1.2-1.00.81.3
Distance traveled after self-admin1.51.74.21.10.2-1.1-1.90.4-1.5-1.50.52.0
Extensor digitorum longus weight1.56.125.92.9-1.12.32.3-0.0-1.5-5.11.52.0
Bone: elastic displacement1.01.11.80.7-1.40.5-0.4-1.31.3-0.4-1.41.3
Bone: elastic work0.30.41.7-0.80.1-0.6-1.3-0.00.20.5-0.20.6
Bone: endosteal estimation9.520.634.3-4.95.7-5.9-5.05.0-4.42.74.0-1.5
Bone: endosteal perimeter12.726.341.7-5.26.3-6.5-5.85.9-5.61.75.1-0.7
Epididymis fat weight1.43.37.4-1.82.1-1.4-0.92.5-2.2-0.42.7-0.4
Delta time in closed arm before/after self-admin0.60.51.40.8-0.70.2-0.7-0.80.40.4-1.01.2
Delta time in open arm before/after self-admin0.70.73.40.1-0.41.11.9-0.20.4-0.50.1-1.0
Diff in mean of infusions in LGA sessions0.20.21.00.1-0.1-0.3-0.30.4-0.2-1.00.50.2
Delay discount exponential model param0.50.50.80.9-0.70.70.8-0.80.90.0-0.8-0.1
Extinction: sum of active levers before priming0.20.20.4-0.10.4-0.10.00.5-0.6-0.50.6-0.0
Active lever presses in extinction session 61.71.72.7-1.51.5-1.5-1.41.6-1.00.71.4-0.2
Bone: final force0.50.93.3-1.30.5-1.0-1.80.2-0.01.2-0.10.5
Bone: final moment0.71.13.6-1.50.5-1.1-1.90.20.11.4-0.20.3
Food consumed during 24 hour testing period2.73.37.1-1.52.2-1.4-0.92.4-2.7-0.02.6-0.5
Glucose0.30.42.10.7-0.4-0.2-0.3-0.30.2-1.5-0.00.9
Heart weight1.11.62.9-0.30.8-1.0-1.31.2-1.6-1.71.51.3
Delay discount hyperbolic model param0.40.41.01.0-0.60.60.6-0.60.7-0.1-0.60.2
Intermittent access intake day 1-15 change0.70.71.8-0.00.7-1.1-1.30.4-1.1-0.50.41.1
Intermittent access intake escalation0.30.30.80.30.2-0.5-0.70.1-0.6-0.40.10.9
Intermittent access intake escalation 20.50.51.2-0.30.8-1.0-1.10.5-0.9-0.10.50.6
Intermitt. access day 1 inactive lever presses2.32.55.6-2.01.8-1.7-1.51.4-0.72.40.8-1.0
Intermitt. access day 15 inactive lever presses1.92.04.1-2.01.6-1.3-1.11.4-0.51.91.0-1.3
Intermitt. access escalation Index1.31.23.21.8-1.30.70.1-1.00.1-1.4-0.71.3
Intermittent access day 1 total infusions0.30.41.0-0.60.7-0.3-0.40.8-0.7-0.11.00.0
Intermittent access day 15 total infusions0.40.41.00.10.6-0.3-0.40.7-1.0-0.81.00.7
Intermittent access terminal intake (last 3 days)0.91.01.8-0.81.3-0.9-0.81.3-1.30.01.40.1
Intermittent access total infusions0.80.91.8-1.01.4-0.8-0.61.2-1.10.41.3-0.2
Intermittent access day 1 locomotion2.02.03.8-1.51.8-1.3-1.31.9-1.50.21.9-0.2
Intermittent access day 15 total locomotion1.41.53.0-1.11.7-1.1-0.81.6-1.30.51.7-0.4
Intermittent access total locomotion3.23.76.5-2.32.6-1.8-1.42.4-1.81.12.3-0.8
Intermittent access standard deviation0.50.61.4-1.21.0-0.9-0.70.5-0.30.70.4-0.5
Left kidney weight0.20.62.60.2-0.3-0.2-1.10.1-0.7-1.10.31.6
Right kidney weight0.10.31.3-0.3-0.1-0.4-1.10.1-0.2-0.2-0.01.0
Cocaine induced anxiety0.20.21.50.0-0.40.1-0.7-0.20.1-0.1-0.21.2
Post-drug Anxiety0.70.82.7-0.40.1-0.7-1.50.6-1.0-0.60.51.6
Baseline Anxiety0.10.10.5-0.1-0.1-0.3-0.40.2-0.5-0.70.30.2
Tail length1.85.610.8-3.32.9-2.3-1.02.5-1.51.82.2-2.8
Length with tail2.17.814.8-3.83.3-3.2-2.23.1-2.01.92.5-2.3
Length without tail0.51.22.1-1.51.0-1.4-1.41.1-0.61.20.7-0.5
Times rat made contact with spout0.50.51.0-0.60.8-0.8-0.80.8-1.00.40.80.1
Lifetime Intake1.01.12.1-1.31.5-0.7-0.51.3-0.91.01.2-0.7
Liver weight, left0.91.54.9-1.70.8-0.70.10.50.71.90.1-2.2
Liver weight, right0.71.23.90.1-1.31.20.6-1.22.00.4-1.20.1
Locomotor activity0.10.20.6-0.30.6-0.40.20.30.10.40.1-0.8
Locomotor testing distance0.71.22.2-1.11.5-1.3-0.41.2-0.80.51.0-1.4
Locomotor testing rearing0.30.41.30.11.0-0.9-0.40.6-1.20.20.4-0.1
Locomotion in novel chamber1.21.54.2-0.30.6-1.6-2.00.9-1.3-1.20.81.2
Locomotion in novel chamber post-restriction1.01.22.4-1.51.2-0.9-0.41.3-0.70.71.2-1.2
Fecal boli incidents, locomotor time 10.20.20.80.7-0.20.40.4-0.10.1-0.90.20.4
Change in fecal boli incidents, locomotor task0.30.31.0-0.0-0.20.1-0.30.3-0.6-1.00.50.8
Time >=10cm from walls, locomotor time 12.02.04.82.2-1.91.00.2-1.40.9-1.4-1.21.7
Bouts of movement, locomotor time 10.30.30.90.5-0.71.00.7-0.60.4-0.3-0.40.2
Total resting periods, locomotor time 10.30.30.90.4-0.71.00.6-0.50.5-0.2-0.40.3
Rest time, locomotor task time 11.51.64.20.3-1.31.31.2-1.42.01.0-1.5-0.6
Distance moved, locomotor task time 11.01.12.4-0.61.1-1.1-1.11.3-1.5-0.21.30.4
Vertical activity count, locomotor time 11.01.02.1-0.81.0-1.3-1.41.0-1.4-0.00.90.5
Time >=10cm from walls, locomotor time 20.70.73.70.20.2-1.2-1.90.1-0.50.1-0.21.1
Bouts of movement, locomotor time 20.10.10.20.10.1-0.0-0.10.3-0.3-0.50.40.1
Total resting periods, locomotor time 20.10.10.30.6-0.40.50.2-0.30.2-0.6-0.10.4
Rest time, locomotor task time 21.41.63.11.4-1.81.51.0-1.30.8-1.5-0.90.9
Distance moved, locomotor task time 20.40.51.4-0.50.8-1.1-1.20.4-0.40.90.10.2
Vertical activity count, locomotor time 21.11.24.7-1.21.3-1.1-0.70.6-0.12.20.1-1.0
Light reinforcement 10.91.66.4-1.60.60.51.50.41.01.00.2-2.5
Light reinforcement 21.21.66.4-1.60.40.51.10.11.31.4-0.2-2.5
Bone: marrow area9.220.033.7-4.85.6-5.8-5.04.9-4.32.73.9-1.4
Bone: maximum diameter4.58.314.9-3.53.4-3.7-3.92.9-2.41.82.3-0.1
Bone: maximum force1.12.04.9-1.91.4-1.5-2.21.2-1.20.71.00.5
Bone: maximum moment1.22.15.4-2.11.4-1.6-2.31.2-1.10.91.00.3
Mean time between licks in bursts1.01.43.20.10.6-0.6-0.91.1-1.8-1.71.51.4
Mean num. licks in bursts0.10.10.2-0.30.20.20.40.20.2-0.20.3-0.5
Cd content in liver3.33.66.32.5-2.32.11.9-2.01.4-1.9-1.50.8
Co content in liver0.40.51.41.2-0.60.60.9-0.60.3-1.0-0.40.1
Cu content in liver0.50.62.4-1.10.5-0.10.30.40.31.20.2-1.5
Fe content in liver1.11.32.40.6-1.11.11.2-1.31.50.8-1.5-0.9
K content in liver0.80.83.0-1.00.5-0.20.20.20.41.7-0.2-1.7
Mg content in liver2.32.34.50.2-0.81.62.1-1.11.61.8-1.3-2.1
Mn content in liver2.93.38.5-0.6-0.71.11.5-1.42.32.9-1.9-2.5
Na content in liver0.60.72.7-0.80.6-0.40.40.20.51.4-0.2-1.6
Rb content in liver2.73.46.01.6-1.82.12.5-2.11.90.6-2.1-1.1
Se content in liver1.51.93.71.9-1.61.91.5-1.40.7-0.9-1.00.6
Sr content in liver0.90.92.6-0.60.6-1.0-1.60.7-0.9-0.10.61.4
Zn content in liver0.10.10.3-0.4-0.10.10.0-0.00.50.4-0.1-0.2
Bone: minimum diameter10.419.428.3-5.05.3-5.2-4.85.1-4.61.94.5-1.0
Time in familiar zone, hab. session 10.60.61.70.00.8-0.40.11.0-1.3-0.71.2-0.2
Time in novel zone, hab. session 10.60.61.40.3-1.00.4-0.3-1.01.10.0-1.20.8
Total zone transitions, hab. session 10.10.10.60.00.3-0.1-0.10.3-0.8-0.10.50.2
Total locomotion distance, hab. session 10.40.62.0-1.30.6-0.6-0.80.30.01.4-0.0-0.6
Locomotion velocity, hab. session 10.70.92.6-1.60.9-0.8-0.70.7-0.11.50.3-1.0
Time in familiar zone, hab. session 20.70.72.50.30.9-0.7-0.20.9-1.6-0.71.00.1
Time in novel zone, hab. session 21.01.03.6-0.4-1.00.7-0.0-1.11.90.8-1.30.1
Total zone transitions, hab. session 20.10.10.50.50.00.50.70.0-0.2-0.20.2-0.3
Total locomotion distance, hab. session 20.40.51.4-0.2-0.11.01.2-0.10.50.9-0.2-1.2
Locomotion velocity, hab. session 20.40.51.4-0.1-0.11.01.2-0.20.50.7-0.1-1.1
Novel to familiar place preference ratio0.60.61.0-0.70.7-0.7-1.00.9-0.8-0.21.00.3
Novelty place preference0.30.30.7-0.60.5-0.6-0.90.7-0.5-0.10.70.3
Time in novel zone, NPP test0.30.30.8-0.40.3-0.6-0.90.5-0.4-0.00.50.4
Total zone transitions, NPP test0.30.41.0-0.2-0.20.71.0-0.30.70.6-0.4-1.0
Total locomotion distance, NPP test0.50.72.3-0.90.10.30.4-0.11.01.5-0.5-1.2
Locomotion velocity, NPP test0.30.51.5-0.90.20.50.70.20.60.80.1-1.2
Intraocular pressure1.92.66.0-1.31.7-1.2-1.02.1-2.1-1.32.50.4
Delta distance traveled before/after self-admin0.70.72.11.5-1.00.90.4-1.00.2-0.4-0.90.8
Delta ambulatory time before/after self-admin0.30.40.70.8-0.60.80.5-0.80.10.2-0.70.3
Parametrial fat weight1.02.06.0-2.51.5-1.2-1.11.1-0.41.90.6-1.2
Pavlov. Cond. lever latency2.12.76.92.1-1.71.91.9-1.20.5-2.6-0.50.8
Pavlov. Cond. magazine entry latency2.73.59.0-2.62.1-2.0-1.51.3-0.33.00.6-1.9
Pavlov. Cond. change in total contacts3.23.49.5-2.52.0-1.8-1.21.3-0.43.10.6-1.9
Pavlov. Cond. index score2.53.18.6-2.31.9-1.9-1.71.3-0.52.90.6-1.3
Pavlov. Cond. latency score2.02.56.5-2.01.8-1.8-1.61.2-0.62.60.6-1.0
Pavlov. Cond. lever contacts2.02.34.7-1.81.7-1.9-1.81.2-0.82.20.7-0.6
Pavlov. Cond. magazine entry number2.43.010.92.4-1.61.41.0-0.8-0.3-3.3-0.02.1
Pavlov. Cond. intertrial magazine entries1.01.22.7-0.81.2-0.30.71.4-1.3-0.61.6-1.2
Pavlov. Cond. lever-magazine prob. diff.2.63.37.6-2.42.0-2.1-1.91.4-0.72.80.7-1.1
Pavlov. Cond. response bias3.64.414.3-2.92.0-2.1-1.81.10.03.80.2-1.9
Pavlov. Cond. lever latency0.30.30.80.7-0.70.70.4-0.40.3-0.9-0.10.7
Pavlov. Cond. magazine entry latency0.60.61.31.1-1.00.40.6-0.80.7-1.1-0.70.5
Pavlov. Cond. change in total contacts0.30.41.6-0.40.6-0.40.40.4-0.30.70.3-1.3
Pavlov. Cond. index score0.10.10.6-0.20.3-0.8-0.50.2-0.20.00.0-0.2
Pavlov. Cond. latency score0.10.10.8-0.20.3-0.9-0.60.2-0.10.1-0.0-0.0
Pavlov. Cond. lever contacts0.20.30.8-0.70.5-0.5-0.20.3-0.10.90.1-0.9
Pavlov. Cond. magazine entry number1.21.52.5-1.61.6-0.8-0.71.4-1.21.21.3-0.9
Pavlov. Cond. intertrial magazine entries8.010.417.2-4.24.0-2.9-2.33.8-3.12.43.4-2.3
Pavlov. Cond. lever-magazine prob. diff.0.10.10.4-0.10.2-0.6-0.30.1-0.0-0.1-0.0-0.1
Pavlov. Cond. response bias0.00.00.2-0.20.0-0.20.1-0.10.20.3-0.2-0.4
Time in closed arm before self-admin0.91.02.00.9-1.00.81.0-1.21.40.5-1.3-0.5
Time in closed arm after self-admin1.01.02.11.4-1.30.60.2-1.31.00.0-1.40.7
Time in open arm before self-admin1.92.17.91.2-0.2-0.6-2.00.1-1.3-1.70.32.8
Time in open arm after self-admin1.61.84.0-0.51.1-0.8-0.91.5-2.0-1.51.90.7
Bone: periosteal estimation7.214.823.2-4.74.6-4.8-4.74.0-3.32.83.1-0.9
Bone: periosteal perimeter5.99.820.9-3.43.4-4.1-4.63.2-2.91.12.60.7
Bone: post-yield work3.14.38.0-1.22.1-2.4-2.72.3-2.8-0.52.21.1
Progressive ratio test 1 active lever presses2.32.44.0-1.92.0-1.5-1.11.9-1.51.11.7-0.9
Progressive ratio test 1 breakpoint2.93.15.3-2.12.3-1.6-1.22.2-1.71.12.0-1.0
Progressive ratio test 1 inactive lever presses2.12.33.6-1.71.9-1.3-0.81.7-1.21.41.6-1.6
Progressive ratio test 2 active lever presses1.92.03.3-1.81.8-1.1-0.81.8-1.21.01.7-1.0
Progressive ratio test 2 breakpoint2.73.15.2-2.02.3-1.7-1.42.2-1.70.92.1-0.8
Progressive ratio test 2 inactive lever presses1.11.22.4-1.31.3-0.30.01.4-0.51.11.5-1.4
Incentive Sensitization - Responses0.90.91.8-1.01.3-0.9-0.71.2-0.80.41.3-0.6
Incentive Sensitization - Breakpoint0.80.81.6-0.91.3-0.9-0.71.1-0.80.31.2-0.5
Sum of active levers in priming session hrs 5-61.01.02.31.2-0.91.31.5-1.00.9-0.2-0.7-0.2
Progressive ratio0.10.10.4-0.20.3-0.4-0.20.3-0.6-0.40.4-0.2
Food seeking constrained by brief footshock1.61.94.0-0.92.0-1.7-0.91.7-1.60.51.6-0.7
Seeking ratio, punishment vs. effort0.20.30.7-0.30.8-0.6-0.40.7-0.50.60.5-0.0
Retroperitoneal fat weight0.92.95.1-2.32.2-1.7-1.02.1-1.41.01.9-1.2
Reaction time number correct0.20.21.00.2-0.40.2-0.2-0.20.5-1.00.10.7
Reaction time mean minus median0.20.20.50.4-0.70.50.4-0.50.6-0.5-0.40.1
Reaction time mean minus median AUC1.41.83.11.1-1.71.61.4-1.51.8-0.4-1.4-0.0
Reaction time num false alarms2.83.85.6-1.92.3-2.3-2.22.3-2.41.11.9-0.1
Reaction time num false alarms AUC2.43.34.8-2.12.2-2.0-1.82.1-2.01.41.8-0.6
Reaction time trials correct on left0.20.21.00.2-0.40.2-0.2-0.20.5-1.00.10.7
Reaction time trials on left0.10.20.90.1-0.40.1-0.2-0.10.5-1.00.10.7
Reaction time mean1.41.94.10.8-1.51.31.3-1.72.00.7-1.9-0.6
Reaction time mean AUC1.72.34.60.9-1.71.31.4-1.92.10.7-2.1-0.7
Median of all reaction times1.52.14.50.7-1.51.21.3-1.72.11.0-2.0-0.9
Reaction time omissions0.40.51.4-1.20.0-0.3-0.3-0.20.91.1-0.5-0.8
Reaction time false alarm rate2.13.04.3-1.82.1-1.9-1.71.9-1.91.71.4-0.7
Reaction time premature initiation rate0.60.81.4-1.11.0-0.7-0.41.2-0.90.31.2-0.7
Reaction time premature initiations0.40.51.3-1.00.7-0.5-0.31.0-0.6-0.21.2-0.4
Std. dev. reaction times0.81.22.80.5-1.21.11.1-1.21.70.4-1.3-0.6
Reaction time trials completed0.10.20.90.1-0.40.1-0.2-0.10.5-1.00.10.7
Reaction time trials AUC0.20.20.90.2-0.50.2-0.1-0.20.5-0.90.00.7
Run reversals in cocaine runway, females0.90.92.8-0.00.2-0.5-1.70.5-1.1-0.60.61.7
Run reversals in cocaine runway, males0.50.51.6-0.30.3-0.8-1.30.4-0.6-0.60.40.9
Latency to leave start box in cocaine runway0.10.20.40.5-0.4-0.1-0.4-0.2-0.3-0.6-0.10.5
Latency to leave start box in cocaine runway, F0.70.72.40.8-0.5-0.4-1.3-0.3-0.5-1.1-0.21.5
Latency to leave start box in cocaine runway, M0.50.51.40.2-0.40.81.2-0.40.60.4-0.4-1.0
Std. dev. time between licks in bursts0.10.10.20.4-0.20.50.30.0-0.5-0.40.30.3
Total sessions with >9 infusions0.20.20.8-0.1-0.20.80.9-0.20.50.2-0.0-0.7
Short access day 1 total inactive lever presses0.40.41.5-0.30.6-0.6-1.20.5-0.40.40.40.8
Short access day 10 total inactive lever presses0.30.40.6-0.70.7-0.4-0.30.8-0.30.60.8-0.7
Short access day 1 total infusions0.30.30.8-0.50.60.00.30.6-0.30.40.7-0.9
Short access day 10 total infusions2.42.64.5-2.12.1-1.4-1.02.0-1.31.31.8-1.1
Short access total infusions1.21.42.4-1.51.5-0.9-0.61.3-0.81.31.1-1.1
Short access day 1 locomotion1.11.22.7-1.31.4-0.7-0.51.5-1.20.01.6-0.3
Short access day 10 total locomotion5.66.210.5-2.73.2-2.4-1.83.2-2.61.03.1-1.3
Short access total locomotion2.12.24.1-1.51.9-1.2-1.02.0-1.70.42.0-0.5
One hour access (0.3 mA shock)0.40.40.9-0.30.8-0.7-0.80.7-0.90.10.80.2
Compulsive drug intake0.40.40.80.5-0.80.0-0.5-0.70.4-0.7-0.70.9
One hour access (shock baseline)0.60.61.5-0.51.1-0.5-0.21.1-1.00.51.2-0.4
Social response proportion0.80.93.90.8-0.2-0.0-0.50.3-0.6-2.00.81.4
Social responses0.10.10.30.10.2-0.2-0.10.4-0.3-0.50.6-0.1
Social time0.81.03.00.50.3-0.7-1.20.7-1.1-1.21.01.7
Soleus weight0.51.53.3-0.51.1-1.3-1.61.1-1.8-0.51.21.3
Bone: stiffness0.20.30.8-0.60.8-0.5-0.50.6-0.90.40.5-0.2
Tibialis anterior weight0.72.36.20.11.2-0.10.51.7-2.5-2.12.40.2
Time to tail flick, vehicle, before self-admin0.50.52.1-0.20.0-0.9-1.5-0.10.2-0.6-0.21.0
Time to tail flick, vehicle, after self-admin1.11.23.3-1.81.1-0.70.21.10.00.31.1-1.7
Time to tail flick, test, before self-admin0.70.62.01.4-0.80.5-0.0-0.5-0.1-0.8-0.21.4
Time to tail flick, test, after self-admin0.20.20.7-0.80.4-0.5-0.10.40.10.50.3-0.8
Delta time to tail flick, vehicle, before/after SA2.12.17.3-1.91.2-0.11.21.00.21.80.8-2.7
Delta time to tail flick, test, before/after SA1.00.94.0-1.50.7-0.50.50.40.31.00.2-2.0
Tibia length0.10.31.3-0.40.0-0.5-1.10.0-0.10.2-0.11.0
Ambulatory time before self-admin1.51.65.1-0.10.7-1.7-2.30.8-1.2-1.10.81.4
Ambulatory time after self-admin1.01.13.70.40.3-1.1-1.90.4-1.1-0.70.41.5
Bone: tissue strength1.01.01.71.2-1.31.10.5-1.20.9-0.6-1.00.9
Total heroin consumption0.30.41.3-0.40.4-0.8-1.00.1-0.21.2-0.2-0.3
Bone: trabecular number1.82.811.6-2.51.2-1.3-1.40.60.53.4-0.3-1.5
Bone: trabecular spacing1.31.75.72.1-0.91.01.0-0.4-0.8-2.40.31.1
Bone: trabecular thickness3.13.710.4-3.21.9-2.0-2.31.5-0.42.40.8-0.8
Bone: trabecular tissue density0.60.92.8-0.2-1.11.00.8-1.01.7-0.3-0.9-0.4
Water consumed over 24 hours0.10.10.2-0.40.2-0.0-0.20.3-0.30.40.30.0
Number of responses in last shaping day2.82.95.8-1.61.8-2.3-2.41.7-1.8-0.21.60.5