Hub : Genes

Mrc2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Mrc2 0.12 0.05 2.8e-14 0.07 0.12 0.13 0.12 1.0e-07 1.6e-13 1.1e-13 2.4e-13
2 NAcc gene expression Mrc2 0.23 0.1 0.0e+00 0.12 0.11 0.14 0.13 1.7e-17 1.1e-16 5.5e-20 4.7e-19
3 IC gene expression Mrc2 0.13 0.07 1.1e-04 0.12 0.1 0.08 0.1 9.9e-06 7.0e-05 2.2e-04 7.5e-05
4 Adipose mRNA stability Mrc2 0.07 0.03 7.1e-08 0.07 0.06 0.07 0.06 7.2e-08 1.6e-07 2.6e-08 2.6e-07
5 pVTA gene expression Mrc2 0.08 0.04 4.6e-06 0.05 0.07 0.08 0.08 7.6e-05 2.5e-06 3.5e-07 5.3e-07
6 Brain gene expression Mrc2 0.27 0.09 0.0e+00 0.3 0.3 0.3 0.3 6.6e-28 3.7e-28 8.4e-28 3.1e-28
7 Adipose gene expression Mrc2 0.11 0.05 8.4e-10 0.06 0.08 0.07 0.08 8.2e-07 1.6e-09 3.1e-08 6.0e-09
8 Liver gene expression Mrc2 0.06 0.03 1.8e-04 0.03 0.02 0.02 0.02 8.6e-04 1.2e-03 3.0e-03 1.6e-03
9 IC mRNA stability Mrc2 0.13 0.07 3.2e-03 0.05 0.02 0.04 0.05 3.5e-03 5.5e-02 9.9e-03 3.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.91.67.90.5-0.11.01.4-0.5-1.0-0.8-2.8-1.2
Area under the delay curve0.40.51.90.50.31.10.60.60.30.5-0.0-1.4
BMI with tail2.17.113.52.32.12.90.13.23.63.72.5-1.7
BMI without tail3.09.317.43.22.43.21.83.83.54.21.5-2.7
Body weight4.218.228.64.84.24.93.25.25.35.40.8-2.2
Weight adjusted by age0.50.81.50.41.01.20.41.10.90.91.1-0.5
Bone surface3.15.710.72.82.63.33.21.61.41.0-3.20.2
Bone volume2.34.29.02.31.92.82.91.30.90.8-3.0-0.7
Breakpoint value in progressive ratio session0.50.62.80.51.0-0.00.70.50.4-0.1-0.71.7
Number of licking bursts0.20.20.50.50.60.50.30.40.70.40.00.7
Context. condit. distance diff. score0.40.52.2-0.6-0.4-0.6-1.2-0.10.20.21.50.1
Locomotion velocity, session 11.11.14.11.10.80.81.90.60.20.1-2.0-0.0
Locomotion distance, session 10.20.31.00.2-0.20.21.00.0-0.3-0.1-0.9-0.7
Locomotion velocity, session 21.51.86.70.71.0-0.21.40.1-0.2-0.7-2.32.6
Locomotion distance, session 20.30.41.7-0.10.1-0.70.4-0.1-0.3-0.6-0.81.3
Locomotion velocity, session 30.20.20.5-0.20.00.20.4-0.4-0.5-0.7-0.40.6
Locomotion distance, session 30.20.30.70.20.50.70.5-0.10.0-0.5-0.60.8
Stereotopy head waving bouts, day 30.81.02.4-0.9-1.3-0.4-0.2-1.2-1.5-1.1-0.5-0.8
Stereotopy head waving duration, day 30.50.61.3-0.7-1.1-0.9-0.2-0.7-1.0-0.50.3-0.7
Locomotion velocity, session 70.50.51.0-0.8-0.8-0.4-0.4-1.0-1.0-0.8-0.50.4
Locomotion distance, session 70.10.20.3-0.5-0.6-0.4-0.5-0.5-0.3-0.20.20.3
Stereotopy head waving bouts, day 71.11.22.4-1.0-1.0-0.8-0.5-1.5-1.5-1.6-0.80.7
Stereotopy head waving duration, day 72.42.94.9-1.6-1.5-1.9-0.8-2.1-2.1-2.2-1.11.3
Locomotion velocity, session 81.51.82.91.41.70.51.11.71.71.60.21.2
Locomotion distance, session 80.20.31.6-0.3-0.2-1.3-0.30.0-0.1-0.10.20.9
Degree of sensitization distance0.30.30.80.0-0.4-0.6-0.40.40.40.90.8-0.4
Degree of sensitization stereotypy1.41.53.0-1.2-0.8-1.0-1.0-1.6-1.4-1.7-0.51.2
Conditioned locomotion0.10.10.5-0.2-0.5-0.7-0.1-0.1-0.20.1-0.3-0.3
Cocaine response after cond. corrected0.50.63.20.10.61.8-0.10.10.70.21.0-0.3
Cocaine response after cond. not corrected0.60.73.50.00.91.90.2-0.30.4-0.50.11.1
Cocaine response before conditioning0.81.02.8-0.10.1-0.30.7-0.7-0.8-1.2-1.71.7
Saline control response1.01.32.71.31.3-0.20.61.61.51.3-0.41.0
Bone: connectivity density0.91.48.00.70.31.01.5-0.2-0.7-0.7-2.8-0.4
Bone: cortical apparent density5.27.113.7-3.0-3.7-2.5-2.1-3.0-3.5-2.50.6-1.6
Bone: cortical area1.21.88.31.31.22.91.20.60.70.6-1.2-0.9
Bone: cortical porosity11.812.824.83.95.04.83.72.93.41.9-2.33.1
Bone: cortical porosity9.810.621.83.64.54.73.22.93.32.2-1.52.0
Bone: cortical thickness3.05.09.0-2.5-2.70.5-2.2-3.0-2.9-2.50.2-1.9
Bone: cortical thickness3.03.67.0-2.1-2.0-0.3-1.7-2.6-2.6-2.5-0.6-0.4
Bone: cortical tissue density5.06.813.1-3.0-3.6-2.5-2.0-2.9-3.5-2.50.5-1.5
Condit. Reinf. active minus inactive responses1.82.03.31.71.80.91.81.51.20.9-1.41.1
Condit. Reinf. active-inactive response ratio0.40.51.30.71.00.50.50.50.50.0-0.81.2
Condit. Reinf. active responses1.92.34.81.91.70.62.21.61.11.1-1.80.8
Condit. Reinf. inactive responses0.80.93.01.20.50.11.71.00.40.8-1.3-0.5
Incentive salience index mean1.61.94.71.51.60.91.91.00.80.3-2.21.3
Condit. Reinf. lever presses0.71.05.40.50.50.01.2-0.1-0.2-0.6-2.31.2
Condit. Reinf. active minus inactive responses3.34.311.42.42.31.82.71.51.20.7-3.41.2
Condit. Reinf. active-inactive response ratio2.83.210.01.92.11.62.11.11.00.4-3.21.2
Condit. Reinf. active responses3.54.810.12.72.41.53.22.01.51.3-3.10.8
Condit. Reinf. inactive responses0.91.13.91.30.7-0.32.01.30.61.0-1.1-0.4
Condit. Reinf. lever presses1.31.84.51.51.50.81.81.00.80.4-2.11.3
Condit. Reinf. lever reinforcers received3.04.29.22.52.21.52.91.81.31.1-3.00.7
Conditioned reinforcement - actives0.50.92.21.10.80.60.21.31.11.50.4-0.7
Conditioned reinforcement - inactives0.71.01.81.21.01.40.41.01.11.30.3-0.4
Conditioned locomotion1.72.33.92.01.71.61.11.91.61.8-0.5-0.4
Patch foraging indifference point 0 sec1.01.84.61.70.70.32.11.40.91.3-1.7-0.9
Patch foraging indifference point AUC0.40.61.40.80.50.20.61.01.11.20.3-0.7
Delay disc. indifference point, 0s delay0.10.10.3-0.4-0.3-0.40.1-0.2-0.6-0.50.1-0.3
Delay disc. indifference point, 16s delay1.51.74.11.11.02.00.81.41.41.40.2-1.6
Delay disc. indifference point, 2s delay0.60.72.00.70.30.51.40.5-0.40.1-1.2-1.1
Delay disc. indifference point, 24s delay1.71.93.41.40.81.41.41.51.41.70.2-1.8
Delay disc. indifference point, 4s delay0.30.31.80.20.81.40.30.30.3-0.10.30.2
Delay disc. indifference point, 8s delay0.60.72.5-0.6-1.00.0-0.0-0.7-1.1-0.6-0.4-1.6
Indifference point function ln k0.20.41.2-0.2-0.30.30.4-0.6-1.0-0.7-1.1-0.2
Indifference point function log k0.20.41.2-0.2-0.30.30.4-0.6-1.0-0.7-1.1-0.2
Patch foraging total patch changes 0 sec1.22.35.41.91.10.72.31.61.31.5-1.7-0.9
Patch foraging total patch changes 12 sec1.01.32.81.40.6-0.71.71.40.91.1-1.4-0.2
Patch foraging total patch changes 18 sec1.11.73.01.61.51.11.11.61.71.4-0.40.2
Patch foraging total patch changes 24 sec1.01.74.11.60.80.62.01.41.11.2-1.5-1.0
Patch foraging total patch changes 6 sec0.91.32.71.51.00.61.61.31.21.1-1.1-0.3
Patch foraging time to switch 0 sec0.10.21.0-0.30.20.0-0.5-0.4-0.2-0.7-0.41.0
Patch foraging water rate 0 sec0.71.52.51.40.81.01.61.31.11.5-0.5-1.3
Patch foraging water rate 12 sec0.20.41.2-0.5-0.31.1-0.4-0.7-0.4-0.30.8-0.4
Patch foraging water rate 18 sec0.40.61.5-0.5-0.6-0.20.4-1.0-1.0-1.1-1.20.1
Patch foraging water rate 24 sec0.10.20.4-0.5-0.20.1-0.5-0.6-0.3-0.60.10.5
Patch foraging water rate 6 sec0.20.31.20.2-0.20.70.6-0.1-0.3-0.1-0.8-1.1
Seeking ratio, delayed vs. immediate footshock0.50.61.70.40.60.6-0.40.90.71.11.3-0.1
Distance traveled before self-admin0.50.62.00.51.11.20.50.30.50.00.21.4
Distance traveled after self-admin0.30.32.2-0.20.50.1-0.3-0.30.2-0.40.41.5
Extensor digitorum longus weight1.55.726.8-1.4-1.7-1.4-3.10.30.61.65.2-2.4
Bone: elastic displacement1.11.32.6-1.4-1.00.4-1.1-1.6-1.5-1.50.50.0
Bone: elastic work0.30.42.20.10.11.50.2-0.4-0.5-0.4-0.5-0.7
Bone: endosteal estimation9.921.736.05.76.04.35.35.05.13.9-3.12.1
Bone: endosteal perimeter12.927.443.86.46.65.45.45.96.15.1-2.01.1
Epididymis fat weight0.61.93.51.51.21.11.11.81.61.90.4-1.2
Delta time in closed arm before/after self-admin0.90.81.9-1.0-0.80.1-1.2-1.2-0.9-1.4-0.1-0.2
Delta time in open arm before/after self-admin0.50.52.5-0.0-0.6-1.60.30.3-0.20.70.2-0.6
Diff in mean of infusions in LGA sessions0.30.30.8-0.9-0.6-0.7-0.4-0.4-0.5-0.50.70.3
Delay discount exponential model param0.50.61.6-0.6-0.5-1.1-0.8-0.7-0.5-0.60.01.3
Extinction: sum of active levers before priming0.10.10.2-0.00.1-0.2-0.10.50.20.20.40.0
Active lever presses in extinction session 61.21.22.91.31.11.01.71.11.11.1-0.60.5
Bone: final force0.60.94.60.50.52.10.6-0.3-0.1-0.4-1.4-0.4
Bone: final moment0.61.04.80.50.62.20.7-0.4-0.3-0.5-1.6-0.3
Food consumed during 24 hour testing period2.53.46.52.21.81.21.82.42.32.6-0.2-0.7
Glucose0.30.52.7-0.50.20.4-1.0-0.10.2-0.11.60.4
Heart weight0.61.02.80.10.31.6-0.80.40.90.81.7-1.1
Delay discount hyperbolic model param0.50.61.4-0.7-0.5-1.1-1.0-0.8-0.4-0.60.21.2
Intermittent access intake day 1-15 change0.40.71.30.51.21.0-0.80.81.00.51.00.7
Intermittent access intake escalation0.71.43.01.01.71.6-0.51.31.50.81.00.6
Intermittent access intake escalation 21.21.42.91.11.71.5-0.21.41.40.90.90.7
Intermitt. access day 1 inactive lever presses0.51.84.11.71.30.92.01.11.00.9-2.00.2
Intermitt. access day 15 inactive lever presses0.71.44.01.40.80.82.00.90.81.0-1.6-0.7
Intermitt. access escalation Index0.91.33.2-1.4-0.8-0.4-1.8-1.1-0.5-0.91.80.8
Intermittent access day 1 total infusions0.20.30.90.80.40.20.90.50.40.5-0.60.0
Intermittent access day 15 total infusions1.62.54.31.81.81.70.22.11.91.91.0-0.4
Intermittent access terminal intake (last 3 days)2.22.95.42.11.91.60.92.32.12.10.4-0.3
Intermittent access total infusions1.31.52.91.61.30.80.91.71.41.6-0.1-0.3
Intermittent access day 1 locomotion1.82.23.82.01.61.41.71.71.61.7-0.8-0.1
Intermittent access day 15 total locomotion1.62.84.72.21.81.31.42.12.12.2-0.2-0.1
Intermittent access total locomotion3.23.86.82.62.11.62.02.32.12.2-1.2-0.1
Intermittent access standard deviation0.10.10.40.60.50.20.10.50.20.3-0.40.0
Left kidney weight0.00.21.3-0.2-0.11.2-0.4-0.3-0.2-0.40.0-0.3
Right kidney weight0.10.32.50.10.11.6-0.1-0.00.10.00.0-0.7
Cocaine induced anxiety1.01.43.4-1.4-1.4-0.5-0.8-1.9-1.4-1.50.10.1
Post-drug Anxiety0.40.40.9-0.8-0.60.3-0.5-0.9-0.4-0.70.8-0.3
Baseline Anxiety0.91.02.00.80.91.10.41.31.41.20.9-0.6
Tail length1.76.516.13.22.52.24.02.51.82.1-2.6-0.5
Length with tail1.67.211.93.42.82.73.43.02.72.7-1.4-0.7
Length without tail0.41.22.61.11.11.30.51.31.61.30.2-0.6
Times rat made contact with spout0.50.61.10.80.90.71.00.71.00.7-0.10.2
Lifetime Intake1.31.62.91.71.30.91.01.71.31.6-0.5-0.4
Liver weight, left2.74.47.32.42.72.02.41.61.81.0-2.32.1
Liver weight, right0.81.42.9-1.1-1.00.5-0.5-1.7-1.6-1.7-1.1-0.4
Locomotor activity0.20.31.40.50.6-0.50.70.30.30.1-0.51.2
Locomotor testing distance0.50.82.40.91.20.01.00.80.90.6-0.51.5
Locomotor testing rearing0.61.26.70.71.3-0.30.10.81.10.3-0.42.6
Locomotion in novel chamber0.81.03.00.61.51.70.40.61.10.40.71.1
Locomotion in novel chamber post-restriction0.60.92.71.10.60.61.61.01.11.2-0.2-0.3
Fecal boli incidents, locomotor time 10.10.10.7-0.1-0.3-0.3-0.2-0.4-0.10.20.80.2
Change in fecal boli incidents, locomotor task0.40.42.0-0.2-0.40.5-0.10.3-0.10.40.7-1.4
Time >=10cm from walls, locomotor time 12.02.13.8-1.7-1.0-1.0-1.6-1.7-0.9-1.21.51.9
Bouts of movement, locomotor time 10.40.41.0-0.6-1.0-0.5-0.4-0.7-0.6-0.30.2-1.0
Total resting periods, locomotor time 10.30.41.2-0.6-1.0-0.2-0.3-0.6-0.5-0.30.1-1.1
Rest time, locomotor task time 10.81.02.0-0.9-1.3-0.9-0.1-1.2-1.4-1.0-0.9-0.0
Distance moved, locomotor task time 10.71.01.81.01.21.30.11.31.31.20.3-0.4
Vertical activity count, locomotor time 10.40.92.51.01.31.60.21.11.10.80.1-0.4
Time >=10cm from walls, locomotor time 20.50.83.90.21.21.1-0.20.00.7-0.20.22.0
Bouts of movement, locomotor time 20.10.10.6-0.0-0.10.10.30.10.50.30.5-0.8
Total resting periods, locomotor time 20.10.20.5-0.4-0.5-0.1-0.2-0.30.1-0.10.6-0.7
Rest time, locomotor task time 21.21.62.9-1.7-1.6-0.9-1.5-1.2-1.1-0.91.4-0.4
Distance moved, locomotor task time 20.40.51.30.81.10.80.40.50.70.0-0.80.7
Vertical activity count, locomotor time 20.71.03.61.21.10.41.20.40.40.0-1.90.7
Light reinforcement 10.51.25.60.4-0.7-0.71.20.4-0.60.4-1.4-2.4
Light reinforcement 20.81.25.20.3-0.8-0.61.30.0-0.8-0.0-1.6-2.3
Bone: marrow area9.621.035.15.65.94.35.24.95.03.8-3.02.2
Bone: maximum diameter4.07.414.23.33.33.83.02.62.62.1-2.0-0.1
Bone: maximum force1.12.08.71.41.33.01.10.80.90.8-0.9-1.2
Bone: maximum moment1.12.08.91.41.33.01.30.70.70.7-1.1-1.1
Mean time between licks in bursts0.61.62.80.80.91.5-0.31.21.31.71.7-1.3
Mean num. licks in bursts0.10.21.40.1-0.2-0.10.30.2-0.00.30.2-1.2
Cd content in liver3.64.07.0-2.4-2.2-2.4-2.6-1.8-1.8-1.32.1-0.1
Co content in liver0.91.13.0-1.2-1.1-1.7-1.0-0.7-0.7-0.51.30.3
Cu content in liver0.20.30.90.60.20.00.90.30.10.4-0.9-0.3
Fe content in liver0.81.03.5-0.5-0.2-0.90.1-0.9-0.9-1.2-1.11.9
K content in liver0.60.62.1-0.0-0.4-0.80.9-0.5-0.6-0.5-1.50.4
Mg content in liver3.63.77.6-1.8-2.5-2.8-0.6-2.1-2.4-1.9-1.4-0.2
Mn content in liver3.13.58.1-1.2-1.8-1.80.6-2.0-2.5-2.2-2.80.3
Na content in liver0.60.62.20.50.4-0.80.70.3-0.0-0.2-1.51.3
Rb content in liver3.03.46.3-2.1-2.0-2.5-1.1-2.1-2.1-2.2-0.50.8
Se content in liver1.31.63.0-1.6-1.7-1.5-1.2-1.3-1.3-1.00.8-0.6
Sr content in liver0.80.72.20.90.91.50.30.80.80.80.1-0.4
Zn content in liver0.70.81.9-1.0-0.9-0.3-1.4-1.1-0.9-0.90.5-0.0
Bone: minimum diameter10.419.028.75.45.25.04.84.84.74.4-2.00.1
Time in familiar zone, hab. session 10.70.71.60.70.7-0.10.41.11.21.30.8-0.1
Time in novel zone, hab. session 10.70.71.5-0.8-0.70.4-0.8-1.2-1.1-1.2-0.20.0
Total zone transitions, hab. session 10.10.10.20.30.20.3-0.10.40.40.50.1-0.4
Total locomotion distance, hab. session 10.40.51.70.70.41.01.10.20.00.1-1.3-0.4
Locomotion velocity, hab. session 10.50.82.11.00.60.91.50.50.20.4-1.4-0.3
Time in familiar zone, hab. session 20.60.71.50.71.0-0.20.01.01.21.00.40.8
Time in novel zone, hab. session 21.01.12.5-0.8-1.20.5-0.1-1.3-1.6-1.2-0.6-1.0
Total zone transitions, hab. session 20.10.10.6-0.0-0.2-0.8-0.20.10.10.20.00.3
Total locomotion distance, hab. session 20.30.40.8-0.1-0.9-0.90.2-0.2-0.6-0.1-0.8-0.8
Locomotion velocity, hab. session 20.30.40.8-0.1-0.9-0.80.2-0.2-0.6-0.0-0.7-0.9
Novel to familiar place preference ratio0.60.61.60.90.71.20.60.80.90.9-0.0-0.4
Novelty place preference0.30.41.10.60.61.00.50.50.70.6-0.0-0.2
Time in novel zone, NPP test0.20.31.00.50.51.00.40.30.50.4-0.10.1
Total zone transitions, NPP test0.20.30.6-0.2-0.7-0.70.3-0.3-0.5-0.3-0.7-0.8
Total locomotion distance, NPP test0.30.42.00.2-0.4-0.20.9-0.2-0.6-0.3-1.4-0.6
Locomotion velocity, NPP test0.30.42.00.3-0.6-0.20.80.1-0.40.2-0.7-1.4
Intraocular pressure2.33.36.51.71.31.81.12.12.32.61.3-1.7
Delta distance traveled before/after self-admin0.50.51.1-0.9-0.7-1.1-0.9-0.8-0.4-0.70.30.3
Delta ambulatory time before/after self-admin0.20.20.6-0.6-0.5-0.8-0.7-0.4-0.2-0.40.1-0.4
Parametrial fat weight0.40.92.30.90.61.51.50.50.10.1-1.3-0.8
Pavlov. Cond. lever latency1.82.35.1-1.7-1.8-1.6-1.8-1.0-1.0-0.42.3-1.1
Pavlov. Cond. magazine entry latency2.43.18.72.01.71.32.71.20.80.5-3.00.7
Pavlov. Cond. change in total contacts2.93.19.31.91.71.02.71.20.90.5-3.01.1
Pavlov. Cond. index score2.32.98.11.91.91.52.31.20.90.5-2.80.9
Pavlov. Cond. latency score1.92.56.11.81.81.42.11.10.90.5-2.51.1
Pavlov. Cond. lever contacts2.32.76.11.82.01.62.01.21.10.5-2.51.3
Pavlov. Cond. magazine entry number1.92.49.4-1.6-1.3-0.7-2.4-0.8-0.3-0.13.1-0.7
Pavlov. Cond. intertrial magazine entries1.11.32.91.00.5-0.30.91.61.31.70.7-1.5
Pavlov. Cond. lever-magazine prob. diff.2.73.38.32.12.01.82.61.31.00.6-2.90.8
Pavlov. Cond. response bias3.54.316.32.11.91.63.11.00.50.1-4.00.9
Pavlov. Cond. lever latency0.30.51.0-0.7-0.7-0.2-1.0-0.5-0.5-0.11.0-0.8
Pavlov. Cond. magazine entry latency0.60.72.2-1.0-0.5-1.0-0.9-0.7-0.4-0.61.50.5
Pavlov. Cond. change in total contacts0.40.61.60.60.7-1.00.90.60.40.3-0.91.3
Pavlov. Cond. index score0.20.31.60.30.7-0.10.50.30.5-0.0-0.21.2
Pavlov. Cond. latency score0.30.32.00.30.70.00.50.20.4-0.1-0.11.4
Pavlov. Cond. lever contacts0.20.30.80.50.5-0.00.90.40.30.1-0.90.6
Pavlov. Cond. magazine entry number1.51.93.01.71.11.31.51.51.11.5-1.3-1.0
Pavlov. Cond. intertrial magazine entries7.210.817.44.23.13.14.03.73.03.6-2.4-1.6
Pavlov. Cond. lever-magazine prob. diff.0.20.21.40.20.6-0.20.40.20.3-0.1-0.11.2
Pavlov. Cond. response bias0.10.10.50.00.2-0.40.30.00.0-0.2-0.40.7
Time in closed arm before self-admin0.20.31.80.00.2-0.60.2-0.20.0-0.1-0.31.3
Time in closed arm after self-admin0.60.61.1-1.0-0.4-0.4-1.0-1.0-0.5-0.80.71.0
Time in open arm before self-admin0.80.92.8-0.70.21.5-1.7-0.60.0-0.71.40.0
Time in open arm after self-admin0.80.91.90.80.80.70.31.21.21.40.8-0.9
Bone: periosteal estimation6.513.820.94.54.54.64.33.63.62.8-3.00.7
Bone: periosteal perimeter5.08.719.23.43.74.42.82.83.12.4-1.20.3
Bone: post-yield work2.13.16.51.92.42.51.01.82.31.70.20.2
Progressive ratio test 1 active lever presses1.61.93.51.91.41.51.31.71.31.5-0.7-0.7
Progressive ratio test 1 breakpoint1.72.13.82.01.41.41.41.81.41.6-0.9-0.8
Progressive ratio test 1 inactive lever presses1.42.03.61.91.41.11.71.51.41.6-1.2-0.2
Progressive ratio test 2 active lever presses3.33.86.72.62.02.11.82.32.02.4-0.7-0.9
Progressive ratio test 2 breakpoint3.84.37.42.72.22.21.82.52.22.5-0.6-0.9
Progressive ratio test 2 inactive lever presses0.91.43.11.50.50.71.31.20.91.8-0.7-1.6
Incentive Sensitization - Responses2.02.84.52.11.81.91.41.92.02.10.0-0.4
Incentive Sensitization - Breakpoint2.22.84.52.11.91.91.41.92.02.10.1-0.3
Sum of active levers in priming session hrs 5-60.80.71.6-1.0-0.9-1.3-0.9-0.7-0.8-0.70.60.5
Progressive ratio0.30.40.90.70.70.30.70.90.80.80.30.3
Food seeking constrained by brief footshock1.82.24.21.72.00.30.81.92.11.4-0.31.6
Seeking ratio, punishment vs. effort0.20.30.70.80.80.20.20.60.70.5-0.70.4
Retroperitoneal fat weight0.31.23.01.30.70.71.71.20.71.1-0.9-1.1
Reaction time number correct0.10.30.9-0.3-0.30.5-0.4-0.3-0.40.10.9-0.9
Reaction time mean minus median0.10.20.5-0.6-0.7-0.3-0.2-0.7-0.4-0.40.4-0.3
Reaction time mean minus median AUC0.82.03.5-1.7-1.9-1.3-1.0-1.9-1.8-1.40.4-0.4
Reaction time num false alarms2.63.65.62.42.31.92.02.02.21.9-1.00.5
Reaction time num false alarms AUC2.03.25.12.32.01.72.21.81.81.7-1.40.3
Reaction time trials correct on left0.10.30.9-0.3-0.30.5-0.4-0.3-0.40.10.9-0.9
Reaction time trials on left0.10.31.0-0.3-0.20.5-0.3-0.2-0.30.10.9-1.0
Reaction time mean1.11.83.3-1.5-1.5-1.4-0.5-1.8-1.5-1.8-0.70.4
Reaction time mean AUC1.42.34.1-1.7-1.6-1.6-0.6-2.0-1.7-2.0-0.60.8
Median of all reaction times1.42.03.7-1.5-1.5-1.5-0.4-1.8-1.5-1.9-1.00.7
Reaction time omissions0.30.51.70.2-0.20.61.3-0.2-0.3-0.2-1.2-1.0
Reaction time false alarm rate2.12.94.42.12.01.32.11.71.81.4-1.61.0
Reaction time premature initiation rate0.50.71.51.00.50.41.01.10.71.2-0.1-0.8
Reaction time premature initiations0.40.71.70.80.40.60.71.00.61.30.4-1.2
Std. dev. reaction times0.61.12.2-1.1-1.4-1.1-0.1-1.5-1.3-1.2-0.4-0.1
Reaction time trials completed0.10.31.0-0.3-0.20.5-0.3-0.2-0.30.10.9-1.0
Reaction time trials AUC0.10.30.9-0.3-0.30.4-0.4-0.3-0.40.10.9-0.9
Run reversals in cocaine runway, females1.21.25.00.50.62.2-0.60.61.00.90.8-1.3
Run reversals in cocaine runway, males0.50.52.00.40.71.40.30.40.60.50.7-0.0
Latency to leave start box in cocaine runway0.10.10.4-0.20.10.3-0.6-0.10.1-0.10.40.2
Latency to leave start box in cocaine runway, F0.50.62.6-0.00.71.6-1.00.00.5-0.10.90.3
Latency to leave start box in cocaine runway, M0.40.42.3-0.2-0.5-1.50.4-0.1-0.3-0.1-0.50.5
Std. dev. time between licks in bursts0.10.10.6-0.2-0.3-0.1-0.8-0.1-0.10.30.4-0.4
Total sessions with >9 infusions0.20.30.70.40.10.4-0.30.50.40.80.6-0.7
Short access day 1 total inactive lever presses0.70.92.81.31.01.70.60.80.80.9-0.7-0.5
Short access day 10 total inactive lever presses0.20.52.00.5-0.10.41.10.20.20.7-0.4-1.4
Short access day 1 total infusions0.10.20.40.60.20.40.10.40.10.6-0.2-0.7
Short access day 10 total infusions0.81.01.91.40.80.71.21.11.01.2-0.7-0.3
Short access total infusions0.50.61.21.10.70.60.80.80.70.8-0.8-0.2
Short access day 1 locomotion1.11.32.81.30.71.40.41.20.91.60.3-1.7
Short access day 10 total locomotion1.93.56.02.42.01.32.22.22.02.2-1.10.1
Short access total locomotion1.51.83.11.71.31.41.11.61.41.8-0.3-0.6
One hour access (0.3 mA shock)1.31.42.41.41.61.60.51.41.51.10.10.3
Compulsive drug intake0.20.30.5-0.6-0.20.4-0.7-0.6-0.2-0.70.70.4
One hour access (shock baseline)0.91.32.41.51.30.80.71.61.41.5-0.4-0.2
Social response proportion0.50.63.8-0.00.00.7-0.50.10.70.71.9-0.3
Social responses0.10.20.30.30.20.00.30.20.60.60.50.6
Social time0.50.71.90.40.71.2-0.20.41.10.91.40.2
Soleus weight0.51.43.11.11.41.80.21.31.61.20.60.2
Bone: stiffness0.20.30.80.60.70.90.30.50.60.4-0.50.0
Tibialis anterior weight0.72.56.31.10.60.1-0.12.01.92.52.0-1.7
Time to tail flick, vehicle, before self-admin0.20.20.7-0.10.30.9-0.0-0.6-0.4-0.7-0.10.5
Time to tail flick, vehicle, after self-admin0.30.41.10.60.20.40.80.70.20.60.0-1.0
Time to tail flick, test, before self-admin0.20.20.6-0.40.1-0.4-0.4-0.50.2-0.40.40.8
Time to tail flick, test, after self-admin0.20.20.60.30.1-0.50.80.20.10.3-0.6-0.2
Delta time to tail flick, vehicle, before/after SA1.00.91.81.20.5-0.01.41.30.71.2-0.8-0.9
Delta time to tail flick, test, before/after SA0.20.20.70.40.0-0.50.80.4-0.20.2-0.8-0.1
Tibia length0.10.31.80.10.21.3-0.1-0.10.1-0.1-0.0-0.7
Ambulatory time before self-admin0.40.62.40.41.11.20.30.20.4-0.10.11.5
Ambulatory time after self-admin0.10.20.8-0.10.40.4-0.3-0.30.1-0.40.00.9
Bone: tissue strength1.21.22.1-1.4-1.1-0.5-1.5-1.4-1.1-1.20.90.4
Total heroin consumption0.70.83.30.30.80.00.60.00.1-0.6-1.41.8
Bone: trabecular number1.22.09.81.10.61.22.00.2-0.4-0.4-3.1-0.8
Bone: trabecular spacing0.81.04.3-0.7-0.3-1.0-1.5-0.00.60.32.10.7
Bone: trabecular thickness2.43.07.01.81.22.62.41.00.50.8-2.2-1.7
Bone: trabecular tissue density0.71.02.8-0.9-1.30.2-0.1-1.0-1.3-0.80.2-1.7
Water consumed over 24 hours0.10.10.60.30.10.40.80.10.20.2-0.2-0.3
Number of responses in last shaping day1.01.03.71.21.41.9-0.01.10.70.7-0.2-0.2