Hub : Genes

Mog

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC gene expression Mog 0.25 0.16 1.7e-04 0.13 0.08 0.06 0.12 4.2e-06 2.4e-04 1.7e-03 6.9e-06
2 pVTA gene expression Mog 0.4 0.17 2.3e-14 0.23 0.19 0.19 0.21 3.9e-18 1.7e-15 3.9e-15 7.6e-17
3 NAcc gene expression Mog 0.35 0.09 0.0e+00 0.17 0.17 0.17 0.17 1.9e-25 2.0e-24 1.5e-25 2.0e-25
4 Brain gene expression Mog 0.47 0.13 0.0e+00 0.31 0.33 0.34 0.34 4.4e-29 1.7e-31 1.7e-32 2.6e-32
5 BLA gene expression Mog 0.32 0.11 3.1e-11 0.16 0.18 0.19 0.19 1.0e-08 4.2e-10 2.8e-10 2.0e-10
6 LHb gene expression Mog 0.25 0.15 5.2e-03 0 0.06 0.05 0.06 3.3e-01 1.6e-02 2.7e-02 1.7e-02
7 RMTg mRNA stability Mog 0.2 0.13 4.4e-03 0.05 0.05 0.02 0.04 2.2e-02 1.8e-02 1.1e-01 2.8e-02
8 RMTg isoform ratio NM_022668.2 0.24 0.14 7.6e-03 0 0.01 0.05 -0 2.4e-01 2.0e-01 2.4e-02 4.3e-01
9 Brain intron excision ratio chr20_1518653_1520418 0.09 0.06 1.1e-05 0.03 0.03 0.03 0.03 1.1e-03 9.6e-04 4.9e-04 1.1e-03
10 NAcc intron excision ratio chr20_1518653_1520418 0.02 0.01 6.3e-04 0.02 0.01 0.01 0.01 1.0e-03 2.2e-03 1.3e-02 3.2e-03
11 pVTA intron excision ratio chr20_1518653_1520418 0.05 0.04 3.8e-04 0.05 0.04 0.04 0.05 4.9e-05 1.6e-04 4.8e-04 5.4e-05
12 pVTA intron excision ratio chr20_1520003_1520418 0.05 0.04 4.4e-04 0.05 0.04 0.03 0.05 5.5e-05 2.4e-04 1.4e-03 9.4e-05
13 NAcc intron excision ratio chr20_1520003_1520418 0.03 0.02 7.7e-05 0.02 0.02 0.02 0.02 3.1e-04 3.2e-04 7.0e-04 2.2e-04
14 Brain intron excision ratio chr20_1520003_1520418 0.09 0.05 2.0e-05 0.03 0.03 0.03 0.03 8.7e-04 8.4e-04 6.1e-04 9.2e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density1.12.03.91.61.51.31.0-1.4-1.4-2.00.6-1.1-1.4-1.71.6-1.41.2
Area under the delay curve1.11.84.2-0.10.1-0.10.50.60.70.71.72.01.81.5-1.71.8-2.0
BMI with tail0.72.55.01.31.41.31.8-1.5-1.1-0.31.51.61.82.2-1.52.1-1.8
BMI without tail0.84.18.60.50.70.61.4-0.30.20.72.42.82.72.9-2.72.9-2.9
Body weight3.415.030.4-2.9-2.4-2.5-1.02.83.53.92.44.65.45.5-5.04.9-4.3
Weight adjusted by age1.02.86.9-1.3-1.6-1.4-0.72.02.01.71.21.71.62.6-1.81.6-1.4
Bone surface0.30.51.8-0.7-0.8-1.0-0.91.21.30.70.70.40.40.2-0.40.2-0.1
Bone volume0.10.21.60.30.20.10.20.20.4-0.21.30.40.20.0-0.10.1-0.1
Breakpoint value in progressive ratio session0.50.83.10.40.40.4-0.2-0.9-1.1-0.4-1.7-1.3-1.0-0.51.0-0.81.0
Number of licking bursts0.20.72.0-1.4-1.1-1.1-1.11.11.01.2-1.0-0.10.20.0-0.30.10.0
Context. condit. distance diff. score3.54.28.2-1.3-1.5-1.4-2.11.20.80.3-2.6-2.8-2.3-2.42.3-2.92.8
Locomotion velocity, session 10.30.41.0-0.6-0.5-0.7-1.00.60.70.6-0.8-0.5-0.2-0.30.0-0.40.7
Locomotion distance, session 11.01.32.51.31.41.31.0-1.6-1.4-1.4-0.2-0.9-1.1-1.11.0-0.90.8
Locomotion velocity, session 20.30.31.6-0.6-0.5-0.5-0.90.10.30.9-1.3-0.40.30.2-0.60.20.2
Locomotion distance, session 20.50.71.30.60.50.40.0-0.7-0.7-0.8-0.5-1.1-1.1-1.01.0-1.11.2
Locomotion velocity, session 30.40.41.21.00.80.90.9-1.1-1.0-0.4-0.2-0.00.0-0.1-0.10.3-0.2
Locomotion distance, session 31.01.12.20.60.60.70.2-0.8-1.0-1.0-0.8-1.3-1.5-1.41.5-1.41.2
Stereotopy head waving bouts, day 31.41.73.5-1.7-1.6-1.6-1.41.51.61.9-0.70.51.31.0-1.00.8-0.7
Stereotopy head waving duration, day 30.91.22.1-1.3-1.2-1.2-0.91.11.31.5-0.20.71.21.0-1.10.9-0.8
Locomotion velocity, session 71.61.84.40.20.50.5-0.0-0.4-0.5-1.0-0.7-1.8-2.1-2.11.6-2.01.9
Locomotion distance, session 71.82.34.61.01.11.30.8-1.1-1.3-1.8-0.1-1.6-2.1-2.02.0-1.91.7
Stereotopy head waving bouts, day 71.61.93.7-0.9-0.7-0.7-0.21.11.41.41.11.71.81.5-1.91.7-1.8
Stereotopy head waving duration, day 71.62.04.0-0.8-0.8-0.9-0.31.21.51.51.01.81.81.6-2.01.8-1.9
Locomotion velocity, session 83.23.98.0-2.8-2.7-2.7-2.82.62.72.5-1.6-0.50.40.4-0.5-0.30.4
Locomotion distance, session 82.13.06.8-0.7-1.1-1.0-1.60.70.4-0.1-2.0-2.4-2.2-1.92.2-2.62.5
Degree of sensitization distance0.30.30.9-0.7-0.8-0.7-0.50.90.90.50.1-0.00.0-0.1-0.0-0.20.2
Degree of sensitization stereotypy0.60.71.7-0.2-0.1-0.20.20.50.70.70.91.11.00.8-1.31.1-1.2
Conditioned locomotion1.41.63.8-0.7-0.7-0.7-0.30.80.91.50.31.41.71.7-1.91.7-1.6
Cocaine response after cond. corrected0.20.30.70.60.50.50.2-0.9-0.7-0.2-0.8-0.6-0.6-0.6-0.0-0.20.3
Cocaine response after cond. not corrected0.40.61.5-0.8-0.9-0.9-0.80.80.91.2-0.50.30.70.5-1.10.6-0.5
Cocaine response before conditioning4.95.99.7-2.1-2.3-2.2-1.33.03.12.61.52.62.82.7-2.62.3-2.2
Saline control response1.21.74.11.11.11.01.6-0.5-0.3-0.42.01.81.21.3-1.21.5-1.7
Bone: connectivity density1.32.05.01.00.80.60.0-0.7-0.9-1.5-0.1-1.7-1.8-2.22.0-2.01.8
Bone: cortical apparent density0.81.33.01.31.41.41.7-1.2-1.1-0.91.21.00.50.7-0.41.0-1.2
Bone: cortical area0.61.02.3-1.1-0.8-0.9-0.41.11.20.80.91.21.01.5-1.01.0-0.9
Bone: cortical porosity0.10.10.40.1-0.0-0.00.20.20.1-0.00.60.50.40.3-0.30.4-0.6
Bone: cortical porosity0.30.41.0-0.7-0.7-0.7-0.41.00.80.50.40.60.50.5-0.40.4-0.5
Bone: cortical thickness1.42.34.51.31.51.42.0-1.3-1.0-1.02.11.81.11.6-1.01.7-1.7
Bone: cortical thickness2.02.56.02.22.02.12.5-1.9-1.9-1.61.50.80.20.60.00.8-1.1
Bone: cortical tissue density0.71.12.51.21.31.21.6-1.1-1.0-0.81.10.90.50.6-0.40.9-1.1
Condit. Reinf. active minus inactive responses0.10.10.20.10.0-0.0-0.2-0.1-0.1-0.1-0.3-0.3-0.4-0.40.2-0.30.3
Condit. Reinf. active-inactive response ratio0.30.30.60.50.50.40.5-0.6-0.4-0.00.30.60.70.5-0.70.8-0.8
Condit. Reinf. active responses0.40.51.40.30.30.40.2-0.6-0.7-0.7-0.7-0.8-1.2-0.80.9-0.90.9
Condit. Reinf. inactive responses1.92.55.31.01.21.30.9-1.5-1.7-1.9-0.6-1.6-2.3-1.62.0-1.81.7
Incentive salience index mean0.81.02.9-1.0-0.9-0.9-1.30.50.40.6-1.7-1.2-0.9-0.80.6-1.11.2
Condit. Reinf. lever presses2.63.811.1-1.6-1.5-1.5-2.30.70.40.7-3.3-2.7-2.0-1.61.7-2.32.6
Condit. Reinf. active minus inactive responses0.50.81.5-0.8-0.8-0.8-0.41.11.21.00.41.10.81.0-1.10.9-0.8
Condit. Reinf. active-inactive response ratio1.21.93.0-1.3-1.3-1.3-0.81.51.71.70.21.31.51.5-1.71.4-1.3
Condit. Reinf. active responses0.10.10.3-0.3-0.3-0.3-0.30.40.4-0.0-0.2-0.2-0.6-0.30.4-0.40.5
Condit. Reinf. inactive responses0.60.92.40.50.50.50.1-0.6-0.8-1.0-0.5-1.1-1.4-1.21.6-1.31.3
Condit. Reinf. lever presses0.81.23.1-0.3-0.0-0.0-0.30.2-0.1-0.8-0.8-1.1-1.8-1.41.7-1.71.6
Condit. Reinf. lever reinforcers received0.20.30.5-0.4-0.4-0.4-0.50.50.4-0.0-0.5-0.4-0.7-0.60.7-0.70.7
Conditioned reinforcement - actives0.41.75.71.41.11.21.60.0-0.2-0.42.41.91.11.3-1.01.2-1.7
Conditioned reinforcement - inactives0.41.02.40.80.90.91.2-0.4-0.5-0.81.51.40.61.4-0.50.8-1.0
Conditioned locomotion0.30.41.30.0-0.1-0.10.20.70.50.31.11.10.70.6-0.60.7-1.0
Patch foraging indifference point 0 sec0.61.75.21.91.71.72.0-0.9-0.7-1.52.30.8-0.0-0.40.4-0.0-0.5
Patch foraging indifference point AUC0.51.12.5-0.8-0.7-0.60.00.91.00.81.01.61.21.6-1.11.4-1.2
Delay disc. indifference point, 0s delay0.70.81.7-0.9-0.7-0.8-0.60.81.01.3-0.20.70.90.6-1.31.0-1.0
Delay disc. indifference point, 16s delay1.82.56.11.72.01.82.1-1.1-0.9-1.02.51.81.11.1-0.91.4-1.7
Delay disc. indifference point, 2s delay1.61.83.3-1.0-0.9-0.8-0.31.21.21.50.51.61.71.6-1.81.7-1.7
Delay disc. indifference point, 24s delay0.60.93.60.60.70.60.9-0.00.2-0.11.91.40.90.8-1.11.1-1.3
Delay disc. indifference point, 4s delay2.72.95.2-1.0-0.9-1.1-0.41.51.61.81.02.12.22.1-2.32.2-2.2
Delay disc. indifference point, 8s delay0.30.62.50.20.10.10.50.40.3-0.01.61.30.80.7-0.40.8-1.1
Indifference point function ln k0.20.51.1-0.7-0.6-0.6-1.00.70.60.3-1.0-0.8-0.6-0.20.6-0.90.8
Indifference point function log k0.20.51.1-0.7-0.6-0.6-1.00.70.60.3-1.0-0.8-0.6-0.20.6-0.90.8
Patch foraging total patch changes 0 sec0.72.06.72.01.81.82.2-1.0-0.7-1.62.61.00.1-0.30.30.2-0.7
Patch foraging total patch changes 12 sec1.21.64.61.71.61.62.0-1.0-0.8-1.52.21.10.10.20.10.5-0.7
Patch foraging total patch changes 18 sec1.22.95.82.32.32.32.4-2.1-2.0-2.31.7-0.0-0.5-0.91.2-0.30.0
Patch foraging total patch changes 24 sec1.13.98.02.82.82.72.7-2.1-2.0-2.82.40.4-0.7-0.90.8-0.20.0
Patch foraging total patch changes 6 sec1.83.09.02.32.22.12.6-1.4-1.0-1.63.01.60.80.3-0.41.0-1.4
Patch foraging time to switch 0 sec0.31.33.61.71.61.61.1-1.9-1.8-1.00.1-0.70.0-0.60.20.00.0
Patch foraging water rate 0 sec0.10.52.70.20.10.20.70.70.8-0.31.61.20.20.6-0.20.3-0.6
Patch foraging water rate 12 sec0.10.30.80.60.80.70.6-0.7-0.6-0.90.60.2-0.4-0.10.3-0.00.2
Patch foraging water rate 18 sec0.00.10.3-0.1-0.2-0.2-0.00.50.40.10.20.4-0.20.0-0.20.1-0.1
Patch foraging water rate 24 sec0.20.31.50.10.10.20.50.10.20.11.20.90.70.3-0.50.6-0.7
Patch foraging water rate 6 sec0.30.41.00.80.90.80.7-0.7-0.8-1.00.40.1-0.4-0.30.4-0.10.2
Seeking ratio, delayed vs. immediate footshock0.30.41.1-0.7-0.8-0.7-0.50.20.60.8-0.50.50.60.7-1.00.9-0.4
Distance traveled before self-admin0.61.23.6-1.9-1.5-1.6-1.61.41.00.8-1.4-0.3-0.3-0.10.5-0.50.6
Distance traveled after self-admin0.81.44.7-2.2-1.5-1.7-1.71.21.21.3-1.20.20.70.4-0.60.50.0
Extensor digitorum longus weight0.31.03.4-1.4-1.3-1.3-1.21.91.80.70.40.1-0.0-0.2-0.1-0.50.3
Bone: elastic displacement0.30.41.00.60.70.50.7-0.4-0.3-0.20.70.80.80.2-0.70.9-1.0
Bone: elastic work0.50.72.1-0.2-0.0-0.20.20.10.20.50.81.21.30.9-1.11.3-1.5
Bone: endosteal estimation4.09.719.0-4.0-4.1-4.1-3.54.24.44.2-0.71.32.32.0-2.21.4-1.2
Bone: endosteal perimeter2.45.912.3-3.5-3.4-3.4-3.53.43.32.7-1.6-0.60.30.2-0.3-0.71.0
Epididymis fat weight3.919.742.35.86.26.26.5-6.0-5.3-4.84.52.20.90.7-0.52.0-2.2
Delta time in closed arm before/after self-admin0.30.30.90.00.30.20.4-0.10.1-0.00.50.90.60.8-0.90.8-0.7
Delta time in open arm before/after self-admin0.20.31.4-1.2-0.6-0.7-0.60.80.50.00.20.60.20.00.20.2-0.0
Diff in mean of infusions in LGA sessions1.52.74.70.90.91.00.2-1.5-1.8-1.5-2.0-2.0-2.2-1.82.1-2.11.8
Delay discount exponential model param1.31.84.30.1-0.00.1-0.5-0.7-0.7-0.8-1.7-2.1-1.8-1.61.7-1.92.1
Extinction: sum of active levers before priming0.91.32.60.70.70.70.1-1.3-1.4-0.9-1.5-1.6-1.4-0.81.4-1.21.3
Active lever presses in extinction session 61.21.23.81.51.51.41.2-1.8-1.9-1.2-0.7-0.2-0.5-0.10.4-0.0-0.0
Bone: final force1.21.94.3-0.10.20.20.9-0.10.20.31.82.01.82.1-1.72.0-2.0
Bone: final moment1.01.63.8-0.30.10.10.80.20.40.31.81.91.61.9-1.51.8-1.8
Food consumed during 24 hour testing period0.81.53.2-1.6-1.6-1.6-1.61.41.41.8-0.90.20.90.8-0.90.6-0.3
Glucose4.06.414.2-3.2-3.3-3.3-3.83.33.02.4-2.5-1.7-0.8-1.20.6-1.71.7
Heart weight1.83.05.7-0.6-0.3-0.40.51.01.40.92.32.42.32.4-2.22.3-2.2
Delay discount hyperbolic model param1.41.84.30.1-0.00.1-0.5-0.6-0.7-0.8-1.6-2.0-1.8-1.61.7-1.92.1
Intermittent access intake day 1-15 change0.00.00.1-0.1-0.2-0.10.00.10.00.2-0.20.30.00.0-0.10.1-0.1
Intermittent access intake escalation0.00.20.60.20.10.30.5-0.2-0.20.10.30.80.60.5-0.60.7-0.7
Intermittent access intake escalation 20.40.71.9-1.2-1.2-1.1-0.91.41.20.9-0.20.40.20.3-0.10.00.0
Intermitt. access day 1 inactive lever presses0.11.33.2-1.8-1.5-1.6-1.71.51.21.3-1.3-0.20.00.30.0-0.20.2
Intermitt. access day 15 inactive lever presses0.21.22.2-1.4-1.4-1.3-0.91.51.41.30.31.00.90.6-1.20.7-0.9
Intermitt. access escalation Index0.62.05.80.20.40.2-0.7-0.9-1.0-0.4-2.4-2.4-1.8-1.41.5-1.61.9
Intermittent access day 1 total infusions0.30.91.81.31.31.31.2-1.2-1.3-1.40.90.4-0.3-0.00.20.1-0.3
Intermittent access day 15 total infusions0.40.91.71.00.91.01.3-0.9-0.9-0.60.91.30.70.5-0.81.0-1.1
Intermittent access terminal intake (last 3 days)0.71.32.81.11.11.21.5-0.7-0.8-0.81.71.70.80.6-1.01.1-1.3
Intermittent access total infusions0.70.91.90.90.90.91.2-0.6-0.6-0.71.31.40.60.5-0.81.0-1.1
Intermittent access day 1 locomotion0.10.20.5-0.00.10.0-0.00.0-0.20.10.20.70.50.5-0.60.6-0.7
Intermittent access day 15 total locomotion0.62.34.2-0.7-0.8-0.8-0.21.11.11.51.02.12.12.0-2.12.0-2.0
Intermittent access total locomotion1.61.93.9-0.8-0.7-0.7-0.20.90.91.30.82.01.91.9-2.01.9-1.8
Intermittent access standard deviation0.31.75.70.60.40.61.20.50.3-0.22.42.41.21.6-1.11.5-1.6
Left kidney weight1.19.016.5-2.2-1.7-1.8-0.52.32.82.52.44.04.13.9-3.93.9-3.4
Right kidney weight1.812.722.4-2.5-2.0-2.1-0.52.83.43.22.94.64.74.7-4.74.5-4.2
Cocaine induced anxiety0.61.63.5-1.6-1.6-1.6-1.91.51.21.1-1.5-0.9-0.7-0.90.6-0.91.0
Post-drug Anxiety1.01.23.4-1.3-1.2-1.1-1.50.80.50.6-1.9-1.1-0.9-0.40.8-1.01.1
Baseline Anxiety1.11.84.91.51.61.71.3-2.2-2.0-1.7-0.5-0.9-1.0-0.20.8-0.60.8
Tail length2.915.426.7-4.6-4.3-4.4-3.24.85.24.80.83.33.93.7-3.83.0-2.8
Length with tail5.323.743.0-5.6-5.4-5.4-4.06.16.65.81.44.24.94.7-4.73.8-3.2
Length without tail2.412.517.4-3.8-3.5-3.5-2.43.74.24.10.83.24.14.1-4.03.6-2.8
Times rat made contact with spout2.12.44.51.71.91.81.4-2.0-2.1-2.0-0.2-1.1-1.5-1.51.5-1.00.9
Lifetime Intake0.70.92.30.70.80.81.1-0.4-0.4-0.51.41.50.80.9-1.01.1-1.2
Liver weight, left3.15.413.1-3.6-3.1-3.3-3.22.92.93.0-1.8-0.10.81.0-0.90.20.1
Liver weight, right4.78.215.0-3.6-3.6-3.6-3.13.63.73.9-0.31.42.62.3-2.41.7-1.5
Locomotor activity2.94.511.0-3.2-3.0-2.9-2.53.33.12.5-0.40.60.80.5-0.70.2-0.3
Locomotor testing distance0.61.54.4-1.9-1.6-1.6-1.52.11.91.30.00.10.2-0.6-0.0-0.40.0
Locomotor testing rearing0.41.33.2-1.7-1.6-1.6-1.41.81.71.4-0.20.40.6-0.0-0.10.1-0.3
Locomotion in novel chamber0.10.10.20.1-0.1-0.2-0.20.40.40.10.40.30.30.4-0.40.3-0.2
Locomotion in novel chamber post-restriction0.20.61.6-0.5-0.3-0.3-0.00.50.50.40.41.20.91.2-1.31.1-1.0
Fecal boli incidents, locomotor time 10.20.62.40.20.30.3-0.0-0.4-0.4-0.7-0.4-0.8-1.3-1.51.0-0.90.9
Change in fecal boli incidents, locomotor task1.01.13.0-0.4-0.5-0.5-0.20.60.71.40.20.91.41.7-1.51.3-1.3
Time >=10cm from walls, locomotor time 11.31.63.2-1.8-1.8-1.7-1.51.41.41.7-0.50.51.20.6-0.90.6-0.6
Bouts of movement, locomotor time 10.40.50.9-0.6-0.7-0.7-0.60.90.70.0-0.1-0.4-0.8-0.70.9-0.90.7
Total resting periods, locomotor time 10.30.41.0-0.7-0.9-0.8-0.71.00.80.4-0.2-0.1-0.5-0.40.5-0.50.3
Rest time, locomotor task time 10.71.22.6-1.4-1.5-1.4-1.31.31.41.6-0.60.40.70.7-0.70.6-0.5
Distance moved, locomotor task time 10.10.31.30.70.70.70.8-0.4-0.2-0.71.10.40.40.4-0.20.1-0.2
Vertical activity count, locomotor time 10.00.20.70.50.50.50.5-0.2-0.2-0.60.80.30.10.40.1-0.3-0.0
Time >=10cm from walls, locomotor time 20.30.91.5-1.1-1.1-1.2-0.91.11.21.00.30.70.80.9-0.90.7-0.6
Bouts of movement, locomotor time 20.62.15.0-2.0-2.2-2.2-1.91.91.81.7-0.60.50.80.7-0.40.7-0.3
Total resting periods, locomotor time 20.62.66.1-2.3-2.5-2.5-2.22.12.01.8-0.90.30.60.6-0.30.4-0.0
Rest time, locomotor task time 21.83.16.4-2.3-2.4-2.3-2.52.22.02.2-2.1-1.0-0.2-0.30.4-0.70.8
Distance moved, locomotor task time 21.52.05.31.71.81.82.1-1.3-1.0-1.42.31.20.60.6-0.80.9-1.0
Vertical activity count, locomotor time 20.20.61.30.91.11.01.0-0.9-0.8-1.01.10.30.10.3-0.00.0-0.1
Light reinforcement 10.10.41.11.00.90.80.9-0.7-0.5-0.61.00.30.00.0-0.10.3-0.2
Light reinforcement 21.02.34.8-0.9-1.1-1.1-0.51.41.71.61.41.81.71.8-2.21.8-1.5
Bone: marrow area3.89.418.2-3.9-4.0-4.0-3.54.14.34.1-0.71.32.32.0-2.21.4-1.2
Bone: maximum diameter1.73.47.1-2.6-2.6-2.6-2.62.72.62.1-0.9-0.20.20.4-0.4-0.30.5
Bone: maximum force0.91.94.2-0.7-0.3-0.40.30.50.80.71.61.92.02.0-1.61.9-1.9
Bone: maximum moment0.91.73.4-0.9-0.5-0.50.10.81.00.71.61.81.81.9-1.51.6-1.7
Mean time between licks in bursts0.53.16.6-2.4-2.6-2.5-2.62.52.22.0-1.5-0.40.10.1-0.1-0.30.6
Mean num. licks in bursts0.82.14.82.21.91.81.7-1.9-1.9-2.00.8-0.4-0.9-0.71.0-0.60.5
Cd content in liver0.40.51.31.01.00.90.9-0.6-0.6-0.91.10.3-0.20.00.1-0.0-0.2
Co content in liver1.01.12.41.41.41.31.6-1.1-0.9-0.91.40.90.40.6-0.50.8-0.9
Cu content in liver2.53.06.02.22.22.11.9-2.2-2.3-2.40.9-0.7-1.3-1.11.5-1.00.8
Fe content in liver0.70.81.51.01.00.91.1-1.0-0.7-0.20.80.90.80.8-1.01.2-1.0
K content in liver0.70.71.10.80.90.80.6-0.9-1.0-1.0-0.0-0.8-0.8-0.90.9-0.80.8
Mg content in liver0.60.61.1-0.6-0.8-0.7-0.90.50.30.2-0.8-1.0-0.8-0.80.9-1.11.0
Mn content in liver3.03.36.3-2.1-2.2-2.1-2.51.81.41.3-2.4-1.8-1.3-1.41.0-1.71.9
Na content in liver0.70.81.81.31.21.21.3-1.2-1.1-1.11.10.40.3-0.00.00.3-0.3
Rb content in liver0.40.41.10.50.40.30.3-0.4-0.6-0.90.2-0.6-0.9-0.71.0-0.90.8
Se content in liver2.22.65.5-2.3-2.3-2.4-2.32.22.12.0-1.3-0.20.30.2-0.5-0.10.3
Sr content in liver0.70.61.1-1.0-1.0-1.1-0.90.90.81.0-0.50.40.61.0-0.50.5-0.4
Zn content in liver0.20.20.5-0.4-0.4-0.5-0.60.50.4-0.10.1-0.5-0.5-0.40.6-0.70.7
Bone: minimum diameter2.34.39.1-3.0-2.9-3.0-2.92.82.82.6-1.4-0.20.60.6-0.6-0.10.4
Time in familiar zone, hab. session 13.03.36.42.12.22.21.8-2.4-2.5-2.30.4-1.2-1.3-1.71.7-1.21.0
Time in novel zone, hab. session 12.52.86.9-2.1-2.0-2.0-1.62.62.61.80.31.31.01.3-1.30.9-0.8
Total zone transitions, hab. session 10.50.71.40.60.60.50.3-0.5-0.6-0.9-0.2-1.0-1.1-1.11.0-1.21.1
Total locomotion distance, hab. session 10.40.60.90.60.70.70.4-0.8-0.8-1.0-0.3-0.8-0.9-1.00.9-0.90.8
Locomotion velocity, hab. session 10.40.61.10.80.80.80.6-1.0-1.1-0.9-0.3-0.7-0.8-0.70.7-0.70.6
Time in familiar zone, hab. session 20.81.01.80.80.90.90.6-1.3-1.3-1.1-0.3-0.9-0.9-1.01.2-0.91.0
Time in novel zone, hab. session 20.80.91.8-0.5-0.5-0.5-0.11.01.10.80.91.20.91.1-1.31.1-1.2
Total zone transitions, hab. session 20.20.30.60.60.80.80.7-0.8-0.7-0.5-0.0-0.2-0.2-0.10.1-0.10.2
Total locomotion distance, hab. session 20.81.11.61.01.01.00.7-1.1-1.2-1.1-0.5-1.0-1.2-1.30.9-1.01.0
Locomotion velocity, hab. session 20.91.21.81.00.91.00.5-1.1-1.2-1.2-0.7-1.2-1.3-1.31.2-1.21.2
Novel to familiar place preference ratio0.30.41.20.60.60.50.7-0.2-0.0-0.21.10.80.50.5-0.60.6-0.8
Novelty place preference0.40.51.40.40.30.30.60.10.20.11.21.00.80.8-0.90.9-1.0
Time in novel zone, NPP test0.50.71.60.20.20.10.40.30.50.31.31.21.01.0-1.11.0-1.1
Total zone transitions, NPP test0.50.71.80.40.60.50.1-0.4-0.4-0.9-0.1-1.0-1.0-1.41.1-1.21.2
Total locomotion distance, NPP test0.81.11.91.11.21.20.8-1.1-1.1-1.40.1-0.8-1.0-1.30.9-0.90.8
Locomotion velocity, NPP test1.42.03.31.41.51.40.9-1.5-1.5-1.7-0.2-1.3-1.5-1.81.5-1.41.3
Intraocular pressure0.30.51.10.70.20.30.2-0.1-0.3-0.7-0.3-0.7-1.0-0.90.9-1.00.9
Delta distance traveled before/after self-admin1.01.12.9-0.2-0.2-0.20.20.10.50.71.21.31.71.0-1.71.7-1.5
Delta ambulatory time before/after self-admin0.40.82.2-0.4-0.4-0.4-0.10.20.60.90.60.81.40.9-1.51.3-1.0
Parametrial fat weight0.51.12.7-0.8-0.4-0.5-0.10.60.70.80.61.41.31.7-1.41.4-1.2
Pavlov. Cond. lever latency2.32.96.72.62.22.22.5-2.0-2.0-2.01.90.90.10.50.30.7-1.0
Pavlov. Cond. magazine entry latency2.53.29.8-1.8-1.9-1.9-2.51.21.01.4-3.1-2.0-1.3-1.10.9-1.71.8
Pavlov. Cond. change in total contacts2.02.14.6-1.8-1.9-1.8-1.81.82.02.1-0.80.31.10.8-1.30.6-0.3
Pavlov. Cond. index score3.03.89.3-2.3-2.4-2.3-2.91.71.62.0-3.0-1.8-0.8-0.90.4-1.41.6
Pavlov. Cond. latency score2.93.78.1-2.4-2.5-2.4-2.81.91.82.1-2.8-1.6-0.6-0.70.2-1.21.4
Pavlov. Cond. lever contacts2.42.96.2-2.5-2.3-2.3-2.52.12.02.0-1.9-0.8-0.1-0.4-0.4-0.60.8
Pavlov. Cond. magazine entry number2.32.99.81.51.51.52.2-0.7-0.5-1.03.12.31.51.4-1.11.8-2.0
Pavlov. Cond. intertrial magazine entries1.51.83.91.62.01.91.9-1.7-1.5-1.91.30.3-0.7-0.40.5-0.1-0.1
Pavlov. Cond. lever-magazine prob. diff.2.93.69.4-2.2-2.2-2.2-2.81.51.41.8-3.1-2.0-1.0-1.10.6-1.51.7
Pavlov. Cond. response bias2.73.38.5-2.2-2.1-2.0-2.71.41.31.7-2.9-1.9-0.9-1.00.5-1.41.7
Pavlov. Cond. lever latency0.30.51.2-0.5-0.6-0.6-0.50.40.61.1-0.00.41.00.8-1.00.8-0.7
Pavlov. Cond. magazine entry latency0.20.30.5-0.7-0.7-0.7-0.50.70.70.7-0.20.40.60.5-0.50.4-0.2
Pavlov. Cond. change in total contacts0.00.10.40.10.20.20.40.00.0-0.20.50.60.30.5-0.30.4-0.4
Pavlov. Cond. index score0.00.00.1-0.3-0.2-0.2-0.20.40.30.0-0.10.1-0.1-0.00.1-0.20.2
Pavlov. Cond. latency score0.00.00.0-0.1-0.0-0.10.00.20.1-0.1-0.10.1-0.00.10.0-0.00.1
Pavlov. Cond. lever contacts0.20.30.80.30.50.50.5-0.3-0.4-0.90.2-0.2-0.7-0.50.7-0.60.5
Pavlov. Cond. magazine entry number0.20.20.60.40.30.30.0-0.5-0.5-0.4-0.4-0.7-0.6-0.50.8-0.60.5
Pavlov. Cond. intertrial magazine entries0.51.22.8-1.2-1.2-1.1-1.50.90.70.7-1.7-1.2-0.9-0.70.8-1.01.1
Pavlov. Cond. lever-magazine prob. diff.0.00.00.1-0.2-0.2-0.2-0.20.40.3-0.0-0.00.1-0.1-0.20.1-0.20.2
Pavlov. Cond. response bias0.10.10.2-0.3-0.2-0.2-0.20.40.2-0.2-0.1-0.1-0.4-0.40.4-0.50.4
Time in closed arm before self-admin0.10.20.40.60.50.60.6-0.5-0.5-0.20.2-0.20.10.00.3-0.0-0.2
Time in closed arm after self-admin1.41.62.41.11.11.11.5-1.1-0.8-0.41.31.41.41.5-1.11.5-1.5
Time in open arm before self-admin0.30.41.30.1-0.3-0.3-0.60.10.20.3-1.0-1.1-0.8-0.00.3-0.80.9
Time in open arm after self-admin1.01.12.1-1.1-1.1-1.0-1.30.90.70.3-1.3-1.2-1.1-0.70.9-1.21.5
Bone: periosteal estimation2.55.911.3-3.0-3.0-3.0-2.33.23.43.00.21.62.12.2-2.01.5-1.4
Bone: periosteal perimeter1.52.96.3-2.4-2.3-2.3-2.02.42.52.1-0.30.51.01.2-1.00.4-0.2
Bone: post-yield work1.62.85.9-2.3-2.3-2.3-2.42.42.21.5-1.2-0.8-0.4-0.10.6-1.01.1
Progressive ratio test 1 active lever presses0.40.71.51.01.11.01.0-1.2-1.1-0.70.60.60.40.6-0.50.7-0.6
Progressive ratio test 1 breakpoint0.40.71.40.91.01.01.0-1.2-1.0-0.60.60.70.50.7-0.60.8-0.7
Progressive ratio test 1 inactive lever presses0.71.83.71.81.91.91.9-1.7-1.7-1.81.10.4-0.30.50.20.2-0.1
Progressive ratio test 2 active lever presses0.81.12.41.51.51.51.5-1.4-1.5-1.20.40.4-0.2-0.20.10.3-0.4
Progressive ratio test 2 breakpoint0.91.22.61.61.61.61.5-1.5-1.6-1.20.40.5-0.1-0.1-0.00.3-0.5
Progressive ratio test 2 inactive lever presses0.10.30.70.20.30.30.50.30.00.00.70.90.40.8-0.60.6-0.7
Incentive Sensitization - Responses0.30.81.81.21.21.20.8-1.1-1.3-1.0-0.5-0.5-0.9-0.80.8-0.60.4
Incentive Sensitization - Breakpoint0.40.91.91.21.21.20.9-1.1-1.4-1.1-0.4-0.4-0.9-0.80.8-0.60.3
Sum of active levers in priming session hrs 5-60.20.20.7-0.3-0.2-0.2-0.5-0.0-0.2-0.1-0.9-0.6-0.5-0.70.3-0.60.5
Progressive ratio0.92.77.4-0.40.20.10.6-0.10.41.10.82.22.32.6-2.42.7-2.1
Food seeking constrained by brief footshock0.00.00.20.5-0.20.00.4-0.00.0-0.20.2-0.1-0.3-0.10.1-0.10.1
Seeking ratio, punishment vs. effort0.91.95.30.5-0.2-0.1-0.30.1-0.4-1.1-0.5-1.8-2.0-2.12.1-2.31.8
Retroperitoneal fat weight0.31.53.7-0.6-0.4-0.40.10.61.00.81.21.71.51.9-1.71.7-1.4
Reaction time number correct0.51.74.21.81.61.82.0-1.4-1.1-1.11.60.90.50.4-0.70.9-1.0
Reaction time mean minus median0.96.014.1-3.6-3.5-3.5-3.83.12.82.6-2.4-0.80.10.2-0.1-0.50.8
Reaction time mean minus median AUC0.63.98.6-2.9-2.8-2.8-2.92.72.42.1-1.7-0.50.00.40.1-0.50.6
Reaction time num false alarms0.10.20.5-0.6-0.6-0.5-0.30.60.70.70.30.10.40.2-0.30.1-0.4
Reaction time num false alarms AUC0.10.30.7-0.7-0.8-0.6-0.40.80.90.80.20.10.40.1-0.40.1-0.4
Reaction time trials correct on left0.51.74.21.81.61.82.0-1.4-1.1-1.11.60.90.50.4-0.70.9-1.0
Reaction time trials on left0.41.53.81.71.51.71.9-1.2-1.0-1.01.50.90.50.5-0.80.9-1.0
Reaction time mean2.65.713.3-3.4-3.3-3.4-3.73.12.62.2-2.5-1.1-0.5-0.70.6-1.21.2
Reaction time mean AUC2.35.712.9-3.4-3.4-3.4-3.63.22.82.3-2.4-0.9-0.4-0.60.4-1.11.0
Median of all reaction times2.43.78.5-2.7-2.6-2.6-2.92.52.01.6-2.0-1.0-0.6-0.90.7-1.21.1
Reaction time omissions2.33.87.9-2.7-2.8-2.7-2.82.42.22.4-2.3-0.80.1-0.3-0.3-0.30.6
Reaction time false alarm rate0.91.32.9-1.7-1.7-1.6-1.51.61.51.3-0.7-0.40.1-0.10.1-0.50.2
Reaction time premature initiation rate0.30.41.2-0.3-0.2-0.3-0.00.30.50.60.60.90.80.8-1.10.9-0.9
Reaction time premature initiations0.41.22.50.80.70.71.1-0.5-0.10.01.41.41.21.0-1.61.6-1.6
Std. dev. reaction times2.06.614.5-3.8-3.7-3.7-3.83.53.12.8-2.4-0.50.10.1-0.2-0.50.6
Reaction time trials completed0.41.53.81.71.51.71.9-1.2-1.0-1.01.50.90.50.5-0.80.9-1.0
Reaction time trials AUC0.41.53.81.71.61.72.0-1.3-1.1-1.01.50.90.50.4-0.70.9-0.9
Run reversals in cocaine runway, females0.50.51.41.00.70.80.8-0.6-0.7-1.20.7-0.2-0.6-0.30.8-0.50.4
Run reversals in cocaine runway, males3.33.67.2-2.6-2.6-2.7-2.42.42.62.5-0.70.61.21.0-1.20.7-0.4
Latency to leave start box in cocaine runway0.00.10.20.5-0.00.20.40.0-0.10.30.10.1-0.00.0-0.30.1-0.4
Latency to leave start box in cocaine runway, F0.20.31.00.2-0.20.1-0.00.10.0-0.1-0.5-0.8-1.0-0.70.6-0.80.8
Latency to leave start box in cocaine runway, M1.41.34.00.40.10.20.80.10.10.81.11.51.51.4-1.51.6-2.0
Std. dev. time between licks in bursts1.73.16.5-2.4-2.5-2.5-2.62.42.32.2-1.7-0.40.10.2-0.3-0.30.6
Total sessions with >9 infusions0.60.71.50.60.70.60.9-0.5-0.5-0.31.11.20.81.0-0.91.0-1.2
Short access day 1 total inactive lever presses0.91.83.5-1.9-1.6-1.7-1.31.61.51.4-0.21.10.91.6-1.10.9-0.6
Short access day 10 total inactive lever presses0.21.53.4-0.5-0.2-0.3-1.00.1-0.3-0.3-1.7-1.8-1.7-1.01.7-1.71.8
Short access day 1 total infusions0.10.10.40.30.50.40.4-0.3-0.3-0.60.70.50.00.2-0.10.1-0.2
Short access day 10 total infusions0.40.71.40.70.70.70.9-0.5-0.5-0.51.21.10.70.9-0.70.8-1.1
Short access total infusions0.60.82.10.60.80.71.0-0.5-0.4-0.51.41.40.81.0-0.91.0-1.1
Short access day 1 locomotion0.20.40.80.70.70.70.4-0.6-0.7-0.90.3-0.5-0.7-0.40.7-0.70.5
Short access day 10 total locomotion0.31.32.1-1.3-1.4-1.5-1.21.41.41.40.10.80.91.2-1.00.7-0.7
Short access total locomotion0.20.30.9-0.3-0.4-0.4-0.20.40.30.40.40.70.61.0-0.50.5-0.7
One hour access (0.3 mA shock)1.01.12.10.90.90.90.4-0.8-1.1-1.3-0.4-1.0-1.5-1.41.5-1.21.1
Compulsive drug intake2.13.19.2-0.2-0.4-0.4-1.3-0.3-0.50.0-2.6-3.0-2.1-2.32.3-2.52.2
One hour access (shock baseline)0.30.72.60.20.40.40.80.1-0.0-0.61.41.60.60.7-0.91.0-0.9
Social response proportion0.20.30.8-0.8-0.9-0.8-0.70.80.70.4-0.2-0.0-0.1-0.30.3-0.20.2
Social responses0.10.10.2-0.4-0.4-0.4-0.20.20.20.20.20.30.30.2-0.10.30.0
Social time2.74.29.8-2.8-2.9-2.9-3.12.11.72.2-3.0-1.2-0.10.00.4-0.80.9
Soleus weight2.57.416.2-3.8-3.8-3.9-4.03.93.73.2-1.8-0.50.5-0.3-0.4-0.50.7
Bone: stiffness0.20.30.60.60.50.50.6-0.7-0.5-0.30.60.40.50.8-0.30.6-0.5
Tibialis anterior weight0.41.43.31.71.81.71.6-1.4-1.2-1.41.30.3-0.0-0.5-0.10.2-0.5
Time to tail flick, vehicle, before self-admin1.01.35.9-1.1-1.1-0.9-1.10.0-0.20.4-2.4-1.4-0.9-0.91.0-1.11.2
Time to tail flick, vehicle, after self-admin0.30.72.3-0.2-0.6-0.5-0.8-0.0-0.00.2-1.3-1.5-0.7-0.70.9-1.01.2
Time to tail flick, test, before self-admin0.10.10.20.40.30.30.4-0.5-0.3-0.2-0.3-0.1-0.40.20.1-0.10.3
Time to tail flick, test, after self-admin0.91.03.6-1.6-1.1-1.2-1.50.30.10.3-1.9-0.8-0.20.70.5-0.50.9
Delta time to tail flick, vehicle, before/after SA0.50.52.01.41.11.00.8-0.6-0.4-0.61.30.10.0-0.0-0.10.1-0.2
Delta time to tail flick, test, before/after SA0.20.30.6-0.20.20.1-0.2-0.5-0.7-0.5-0.7-0.7-0.3-0.30.7-0.50.5
Tibia length2.67.213.2-3.5-3.2-3.2-2.63.23.43.6-0.21.52.52.5-2.41.9-1.6
Ambulatory time before self-admin0.20.51.6-1.3-0.9-1.0-1.00.80.50.4-1.1-0.1-0.3-0.10.5-0.40.4
Ambulatory time after self-admin0.71.23.9-2.0-1.4-1.5-1.51.00.91.2-1.20.10.70.3-0.60.5-0.0
Bone: tissue strength0.30.30.8-0.1-0.0-0.10.20.10.30.20.60.90.90.8-0.80.8-0.7
Total heroin consumption0.50.62.0-1.0-0.7-0.8-1.10.50.30.2-1.4-0.6-0.4-0.50.5-0.50.9
Bone: trabecular number1.01.83.51.71.71.61.2-1.6-1.6-1.90.9-0.8-1.0-1.41.2-0.90.7
Bone: trabecular spacing2.23.26.1-1.8-1.6-1.6-0.91.71.92.10.31.81.92.5-2.21.9-1.8
Bone: trabecular thickness1.11.52.71.31.21.20.8-1.1-1.2-1.50.0-1.1-1.4-1.71.4-1.31.1
Bone: trabecular tissue density0.61.12.70.1-0.10.00.70.50.60.41.51.61.31.4-1.11.4-1.6
Water consumed over 24 hours0.10.10.4-0.3-0.4-0.5-0.60.30.30.6-0.6-0.10.20.1-0.20.10.1
Number of responses in last shaping day0.50.61.4-0.7-0.5-0.50.00.71.00.41.20.91.00.7-1.10.9-0.5