Hub : Genes

Mob4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Mob4 0.05 0.04 3.2e-05 0.02 0.03 0.03 0.03 9.7e-04 9.5e-05 4.4e-04 5.4e-04
2 Brain gene expression Mob4 0.04 0.05 6.2e-03 0.03 0.01 0.02 0.03 3.8e-04 1.5e-02 3.6e-03 1.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density6.010.012.4-3.52.7
Area under the delay curve0.10.20.20.3-0.5
BMI with tail3.912.614.23.8-3.3
BMI without tail0.10.20.30.2-0.5
Body weight1.25.25.9-2.12.4
Weight adjusted by age0.60.70.8-0.90.7
Bone surface6.010.512.6-3.62.9
Bone volume6.110.312.8-3.62.8
Breakpoint value in progressive ratio session0.10.10.30.00.5
Number of licking bursts0.70.80.90.9-0.8
Context. condit. distance diff. score0.91.11.41.2-0.9
Locomotion velocity, session 12.42.64.21.0-2.0
Locomotion distance, session 10.50.61.00.4-1.0
Locomotion velocity, session 21.51.72.90.7-1.7
Locomotion distance, session 20.20.20.30.4-0.6
Locomotion velocity, session 30.10.10.1-0.20.3
Locomotion distance, session 30.00.00.00.1-0.1
Stereotopy head waving bouts, day 31.11.31.41.2-1.1
Stereotopy head waving duration, day 30.10.10.10.3-0.3
Locomotion velocity, session 71.82.03.40.7-1.8
Locomotion distance, session 70.10.10.20.2-0.4
Stereotopy head waving bouts, day 70.10.10.3-0.5-0.1
Stereotopy head waving duration, day 70.10.10.1-0.3-0.3
Locomotion velocity, session 81.51.82.90.8-1.7
Locomotion distance, session 81.11.61.71.2-1.3
Degree of sensitization distance0.00.00.0-0.1-0.0
Degree of sensitization stereotypy0.10.10.3-0.5-0.0
Conditioned locomotion2.02.33.2-1.21.8
Cocaine response after cond. corrected1.01.21.4-1.21.0
Cocaine response after cond. not corrected1.92.12.6-1.61.2
Cocaine response before conditioning0.00.00.00.1-0.2
Saline control response0.10.10.20.40.0
Bone: connectivity density2.74.35.7-2.41.7
Bone: cortical apparent density7.19.311.73.4-2.7
Bone: cortical area0.20.30.3-0.50.6
Bone: cortical porosity5.25.76.4-2.52.2
Bone: cortical porosity7.68.38.9-3.02.8
Bone: cortical thickness1.32.12.61.6-1.3
Bone: cortical thickness1.82.12.21.4-1.5
Bone: cortical tissue density7.29.511.83.4-2.7
Condit. Reinf. active minus inactive responses0.10.20.3-0.20.5
Condit. Reinf. active-inactive response ratio0.00.00.00.0-0.2
Condit. Reinf. active responses0.80.91.3-0.81.1
Condit. Reinf. inactive responses0.40.50.7-0.50.9
Incentive salience index mean0.20.20.4-0.30.6
Condit. Reinf. lever presses0.40.50.6-0.60.8
Condit. Reinf. active minus inactive responses3.54.34.9-1.92.2
Condit. Reinf. active-inactive response ratio0.50.50.6-0.60.8
Condit. Reinf. active responses1.72.42.9-1.41.7
Condit. Reinf. inactive responses0.10.10.2-0.50.3
Condit. Reinf. lever presses0.40.50.50.7-0.7
Condit. Reinf. lever reinforcers received1.41.92.2-1.31.5
Conditioned reinforcement - actives0.00.00.0-0.10.1
Conditioned reinforcement - inactives0.10.10.1-0.3-0.0
Conditioned locomotion0.30.40.60.8-0.3
Patch foraging indifference point 0 sec1.62.53.41.2-1.9
Patch foraging indifference point AUC0.10.10.2-0.40.3
Delay disc. indifference point, 0s delay2.22.42.41.6-1.5
Delay disc. indifference point, 16s delay0.10.10.10.1-0.4
Delay disc. indifference point, 2s delay1.21.31.71.3-1.0
Delay disc. indifference point, 24s delay0.30.30.30.5-0.6
Delay disc. indifference point, 4s delay1.11.21.41.0-1.2
Delay disc. indifference point, 8s delay0.20.20.4-0.60.2
Indifference point function ln k1.82.42.71.5-1.6
Indifference point function log k1.82.42.71.5-1.6
Patch foraging total patch changes 0 sec1.62.53.11.4-1.8
Patch foraging total patch changes 12 sec0.40.60.60.7-0.8
Patch foraging total patch changes 18 sec3.03.95.01.7-2.2
Patch foraging total patch changes 24 sec0.00.00.0-0.0-0.2
Patch foraging total patch changes 6 sec0.60.91.40.7-1.2
Patch foraging time to switch 0 sec0.10.10.2-0.40.1
Patch foraging water rate 0 sec0.20.30.5-0.10.7
Patch foraging water rate 12 sec0.50.80.90.9-0.8
Patch foraging water rate 18 sec0.30.40.6-0.30.8
Patch foraging water rate 24 sec0.20.20.3-0.30.6
Patch foraging water rate 6 sec0.20.30.60.10.8
Seeking ratio, delayed vs. immediate footshock1.82.02.1-1.41.5
Distance traveled before self-admin2.02.12.5-1.61.3
Distance traveled after self-admin0.30.30.60.8-0.2
Extensor digitorum longus weight1.55.86.82.6-2.2
Bone: elastic displacement0.40.50.80.9-0.5
Bone: elastic work1.01.21.3-1.11.1
Bone: endosteal estimation4.910.811.8-3.43.1
Bone: endosteal perimeter4.49.110.5-3.22.8
Epididymis fat weight2.86.68.6-2.12.9
Delta time in closed arm before/after self-admin0.20.20.20.3-0.5
Delta time in open arm before/after self-admin4.64.45.4-2.31.9
Diff in mean of infusions in LGA sessions0.10.20.2-0.40.4
Delay discount exponential model param0.10.10.2-0.20.4
Extinction: sum of active levers before priming1.31.31.8-0.91.3
Active lever presses in extinction session 60.60.60.9-0.50.9
Bone: final force2.84.55.8-1.82.4
Bone: final moment2.23.65.0-1.52.2
Food consumed during 24 hour testing period0.10.10.1-0.30.3
Glucose0.10.20.30.50.4
Heart weight0.00.00.10.3-0.0
Delay discount hyperbolic model param0.30.30.4-0.50.6
Intermittent access intake day 1-15 change0.30.30.50.7-0.1
Intermittent access intake escalation0.20.20.40.6-0.1
Intermittent access intake escalation 20.10.10.2-0.10.4
Intermitt. access day 1 inactive lever presses0.80.81.31.2-0.6
Intermitt. access day 15 inactive lever presses0.00.00.10.3-0.1
Intermitt. access escalation Index1.61.52.4-0.71.5
Intermittent access day 1 total infusions1.41.72.5-0.91.6
Intermittent access day 15 total infusions0.80.91.7-0.31.3
Intermittent access terminal intake (last 3 days)0.40.40.8-0.10.9
Intermittent access total infusions1.41.52.5-0.71.6
Intermittent access day 1 locomotion0.00.00.10.10.2
Intermittent access day 15 total locomotion0.60.70.8-0.70.9
Intermittent access total locomotion0.40.40.7-0.30.9
Intermittent access standard deviation0.30.30.40.60.5
Left kidney weight0.10.30.4-0.60.5
Right kidney weight0.10.20.4-0.60.4
Cocaine induced anxiety0.10.10.20.40.0
Post-drug Anxiety0.00.00.00.2-0.2
Baseline Anxiety0.10.10.3-0.5-0.0
Tail length12.136.638.7-6.25.9
Length with tail12.545.948.3-7.06.6
Length without tail1.63.53.8-1.82.0
Times rat made contact with spout0.00.00.0-0.20.2
Lifetime Intake0.60.71.3-0.41.1
Liver weight, left1.42.22.8-1.71.3
Liver weight, right1.01.72.4-1.51.1
Locomotor activity0.10.20.3-0.40.5
Locomotor testing distance0.00.00.00.1-0.1
Locomotor testing rearing0.30.50.6-0.60.8
Locomotion in novel chamber1.31.62.31.5-1.0
Locomotion in novel chamber post-restriction1.21.51.51.2-1.2
Fecal boli incidents, locomotor time 11.92.12.6-1.61.2
Change in fecal boli incidents, locomotor task0.20.20.20.4-0.4
Time >=10cm from walls, locomotor time 10.30.30.6-0.1-0.8
Bouts of movement, locomotor time 10.00.00.1-0.2-0.2
Total resting periods, locomotor time 10.50.60.90.5-1.0
Rest time, locomotor task time 10.20.20.30.5-0.3
Distance moved, locomotor task time 10.10.10.1-0.30.1
Vertical activity count, locomotor time 10.00.00.10.3-0.2
Time >=10cm from walls, locomotor time 20.20.20.4-0.60.3
Bouts of movement, locomotor time 21.21.31.51.0-1.2
Total resting periods, locomotor time 21.21.31.51.1-1.2
Rest time, locomotor task time 20.00.00.10.3-0.0
Distance moved, locomotor task time 20.10.10.1-0.2-0.2
Vertical activity count, locomotor time 20.40.40.50.6-0.7
Light reinforcement 11.52.84.72.2-0.9
Light reinforcement 20.00.10.10.40.1
Bone: marrow area4.610.011.0-3.33.0
Bone: maximum diameter0.81.41.8-1.31.0
Bone: maximum force3.96.77.6-2.42.8
Bone: maximum moment3.25.56.6-2.12.6
Mean time between licks in bursts0.10.20.20.4-0.4
Mean num. licks in bursts0.40.40.5-0.70.6
Cd content in liver0.70.81.0-0.71.0
Co content in liver0.50.60.70.8-0.7
Cu content in liver0.10.10.1-0.20.3
Fe content in liver2.53.03.7-1.51.9
K content in liver0.00.00.00.0-0.0
Mg content in liver0.20.20.3-0.40.5
Mn content in liver1.72.02.31.5-1.3
Na content in liver0.60.60.7-0.90.7
Rb content in liver0.40.50.7-0.80.5
Se content in liver0.30.30.70.10.8
Sr content in liver0.60.61.2-0.11.1
Zn content in liver0.00.00.0-0.10.0
Bone: minimum diameter1.01.92.2-1.31.5
Time in familiar zone, hab. session 10.00.00.0-0.1-0.2
Time in novel zone, hab. session 10.00.00.00.20.1
Total zone transitions, hab. session 10.40.51.00.2-1.0
Total locomotion distance, hab. session 10.00.00.0-0.2-0.1
Locomotion velocity, hab. session 10.20.30.3-0.60.5
Time in familiar zone, hab. session 21.61.71.71.3-1.3
Time in novel zone, hab. session 20.90.91.3-0.81.1
Total zone transitions, hab. session 20.10.10.1-0.40.1
Total locomotion distance, hab. session 20.50.70.8-0.80.9
Locomotion velocity, hab. session 20.71.01.0-1.01.0
Novel to familiar place preference ratio3.03.14.2-1.42.0
Novelty place preference3.03.14.1-1.42.0
Time in novel zone, NPP test2.42.53.4-1.21.9
Total zone transitions, NPP test0.10.20.20.4-0.4
Total locomotion distance, NPP test0.10.20.40.6-0.1
Locomotion velocity, NPP test0.10.20.30.6-0.0
Intraocular pressure3.44.85.32.3-2.1
Delta distance traveled before/after self-admin1.41.52.51.6-0.7
Delta ambulatory time before/after self-admin0.90.91.81.4-0.2
Parametrial fat weight0.00.00.0-0.00.1
Pavlov. Cond. lever latency0.20.20.30.4-0.5
Pavlov. Cond. magazine entry latency0.00.00.0-0.20.2
Pavlov. Cond. change in total contacts0.10.10.10.3-0.3
Pavlov. Cond. index score0.20.20.3-0.30.6
Pavlov. Cond. latency score0.30.40.6-0.50.8
Pavlov. Cond. lever contacts0.20.30.4-0.30.7
Pavlov. Cond. magazine entry number0.10.10.20.4-0.3
Pavlov. Cond. intertrial magazine entries1.41.72.1-1.21.5
Pavlov. Cond. lever-magazine prob. diff.0.00.00.1-0.10.3
Pavlov. Cond. response bias0.10.10.2-0.30.4
Pavlov. Cond. lever latency0.91.31.8-0.81.4
Pavlov. Cond. magazine entry latency0.50.61.00.3-1.0
Pavlov. Cond. change in total contacts0.60.81.20.5-1.1
Pavlov. Cond. index score0.60.81.20.6-1.1
Pavlov. Cond. latency score0.40.50.80.5-0.9
Pavlov. Cond. lever contacts0.50.60.90.6-0.9
Pavlov. Cond. magazine entry number0.00.10.10.30.0
Pavlov. Cond. intertrial magazine entries0.10.10.10.30.3
Pavlov. Cond. lever-magazine prob. diff.0.60.81.20.6-1.1
Pavlov. Cond. response bias0.20.20.40.0-0.7
Time in closed arm before self-admin4.95.56.4-2.52.2
Time in closed arm after self-admin0.40.50.8-0.90.3
Time in open arm before self-admin4.14.46.62.6-1.5
Time in open arm after self-admin0.60.60.8-0.70.9
Bone: periosteal estimation3.26.56.8-2.62.5
Bone: periosteal perimeter2.43.93.9-2.02.0
Bone: post-yield work1.92.63.1-1.41.7
Progressive ratio test 1 active lever presses0.30.30.5-0.30.7
Progressive ratio test 1 breakpoint0.30.30.5-0.30.7
Progressive ratio test 1 inactive lever presses0.50.51.11.00.0
Progressive ratio test 2 active lever presses0.40.50.6-0.60.8
Progressive ratio test 2 breakpoint0.00.10.1-0.00.3
Progressive ratio test 2 inactive lever presses0.00.10.10.30.1
Incentive Sensitization - Responses0.70.80.8-0.90.9
Incentive Sensitization - Breakpoint0.60.60.6-0.80.8
Sum of active levers in priming session hrs 5-61.51.41.7-1.01.3
Progressive ratio0.80.91.20.8-1.1
Food seeking constrained by brief footshock0.00.00.1-0.20.1
Seeking ratio, punishment vs. effort1.21.51.7-1.21.3
Retroperitoneal fat weight0.20.81.6-0.21.3
Reaction time number correct0.50.70.80.9-0.7
Reaction time mean minus median1.72.33.6-1.01.9
Reaction time mean minus median AUC0.81.11.7-0.71.3
Reaction time num false alarms3.14.24.82.2-1.9
Reaction time num false alarms AUC3.54.85.42.3-2.1
Reaction time trials correct on left0.50.70.80.9-0.7
Reaction time trials on left0.40.50.70.8-0.6
Reaction time mean3.04.25.2-1.82.3
Reaction time mean AUC2.73.64.8-1.62.2
Median of all reaction times2.53.53.9-1.72.0
Reaction time omissions1.01.31.9-0.91.4
Reaction time false alarm rate1.52.02.21.5-1.4
Reaction time premature initiation rate2.43.33.71.9-1.7
Reaction time premature initiations3.24.65.32.3-2.0
Std. dev. reaction times2.73.84.8-1.62.2
Reaction time trials completed0.40.50.70.8-0.6
Reaction time trials AUC0.40.60.80.9-0.6
Run reversals in cocaine runway, females0.10.10.1-0.0-0.4
Run reversals in cocaine runway, males0.40.40.40.6-0.6
Latency to leave start box in cocaine runway6.67.17.72.8-2.5
Latency to leave start box in cocaine runway, F5.25.76.22.5-2.3
Latency to leave start box in cocaine runway, M1.61.51.81.1-1.4
Std. dev. time between licks in bursts2.63.14.52.1-1.3
Total sessions with >9 infusions0.40.40.70.9-0.3
Short access day 1 total inactive lever presses0.10.10.20.40.2
Short access day 10 total inactive lever presses0.00.00.10.30.1
Short access day 1 total infusions0.10.10.10.30.4
Short access day 10 total infusions0.80.91.5-0.51.2
Short access total infusions0.10.10.10.30.3
Short access day 1 locomotion0.00.00.10.3-0.0
Short access day 10 total locomotion0.10.10.10.3-0.1
Short access total locomotion0.20.20.3-0.40.5
One hour access (0.3 mA shock)0.30.30.6-0.20.8
Compulsive drug intake0.30.30.60.3-0.7
One hour access (shock baseline)1.51.72.9-0.81.7
Social response proportion5.15.56.4-2.22.5
Social responses2.83.65.6-1.32.4
Social time1.01.42.2-0.71.5
Soleus weight0.10.30.4-0.50.6
Bone: stiffness4.77.47.8-2.62.8
Tibialis anterior weight0.51.81.91.3-1.4
Time to tail flick, vehicle, before self-admin0.10.10.20.1-0.5
Time to tail flick, vehicle, after self-admin0.10.10.2-0.50.0
Time to tail flick, test, before self-admin0.70.70.80.9-0.8
Time to tail flick, test, after self-admin0.30.30.60.8-0.1
Delta time to tail flick, vehicle, before/after SA0.10.10.1-0.10.4
Delta time to tail flick, test, before/after SA0.10.10.10.3-0.0
Tibia length6.317.820.1-4.53.9
Ambulatory time before self-admin0.80.81.0-1.00.8
Ambulatory time after self-admin1.11.22.11.4-0.5
Bone: tissue strength1.41.41.6-1.11.3
Total heroin consumption0.10.10.2-0.20.4
Bone: trabecular number3.65.77.6-2.81.9
Bone: trabecular spacing0.70.91.10.8-1.1
Bone: trabecular thickness1.51.82.3-1.51.1
Bone: trabecular tissue density0.00.10.10.40.0
Water consumed over 24 hours0.91.11.21.0-1.1
Number of responses in last shaping day0.30.30.50.7-0.3